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Skin hazards in American industry. Part III
213
ABSTRACTS to
November.
Other
Mucor,
from
May
Phoma,
Rhizopw,
Trichoderma,
several
other
cultured
were
Hormodendrum,
Trichothecium,
Macrosporium,
Aspergillq Fusarium,
and
varieties.
The Incidence Am.
fungi
J. M.
of Aspirin SC. ZOO:
Hypersensitivity.
390,
Gardner,
E.,
and
Blanton,
W.
B.:
1940.
The writers attempted to determine by several methods the incidence of hypersensitiveness to aspirin. The records of 467 allergic patients, more than half of whom had asthma, were reviewed as to the use of aspirin and the effect noticed from its use. There were found five patients in whom aspirin was thought to influence the development of allergic symptoms. A group of fifty allergic patients were questioned in detail regarding the use of aspirin and quinine, and in none was a hist,ory of allergic symptoms provoked by their use elicited. Five grains of aspirin were given to 103 consecutive patients at the clinic (after a negative history of aspirin sensitivity had been obtained), and the patients were obtained for two hours. None of the 103 patients reacted violently to the drug, although two asthmatic pat:ients complained of a feeling of slight chest constriction. Ninety-five allergists throughout the country were then circularized. Forty-six answered the questions regarding incidence of aspirin sensitivity. The average incidence based upon the answers received from this group was 0.2 per cent.
Dermatology UKDER
THE
DIRECTION
OF MAR.IO~V
JOSEPH
Skin
Hazards
Bulletin
No.
in American 249,
Industry.
Government
SULZBERGER,
GOODLIAN,
M.D.,
Part
Printing
III.
Office,
M.D.,
NEW
YORK,
AND
BOSTON
Schwartz, Washington,
L.: D.
Public C., 1939.
Health
This bulletin represents the third of a series of studies of skin hazards in American industry. The volume consists of eleven contributions dealing with skin hazards in the citrus fruit industry, cigar manufacture, acid manufacture, pulp and paper manufacture, iron and steel manufacture, and the manufacture of organic solvents, of chromic acid and chromates, of glass, and of explosives. In addition, there are considerations of skin hazards caused by paints, varnishes, and lacquers, as well as skin hazards in photography, printing, and allied trades. This bulletin and its two companions are indispensable for those interested in occupational dermatitis.
Sensitization Landsteiner,
to Picric K.,
and
Acid: DiSomma,
Subsidiary A. A.:
Agents J. Exper.
and Mode Med.
72:
361,
of Sensitization. 1940.
Previously published studies have dealt with the correlation of sensitization phen.omena with the relative lability of chemicals; the more labile the compound, the greater its sensitizing capacity. In this paper the authors have studies picric acid, a sulbstance which is chemically similar to the nitro compounds previously studied, but in which the NO, groups are not readily replaced. It was chosen because it was known to produce clinical sensitivity in the human being. In guinea pigs it was found that the application to the skin of dilute solutions of picric acid alone did not readily produce sensitivity. However, a more frequent sensitization was achieved by the use of butesin and picric acid (butesin picrate) or by the application of picric acid to an area which had been inflamed by the previous application of cantharides. A still greater degree of sensitization was achieved when butesin picrate was applied to the area previously treated with cantharides.
c
ABSTRACTS to
November.
Other
Mucor,
from
May
Phoma,
Rhizopw,
Trichoderma,
several
other
cultured
were
Hormodendrum,
Trichothecium,
Macrosporium,
Aspergillq Fusarium,
and
varieties.
The Incidence Am.
fungi
J. M.
of Aspirin SC. ZOO:
Hypersensitivity.
390,
Gardner,
E.,
and
Blanton,
W.
B.:
1940.
The writers attempted to determine by several methods the incidence of hypersensitiveness to aspirin. The records of 467 allergic patients, more than half of whom had asthma, were reviewed as to the use of aspirin and the effect noticed from its use. There were found five patients in whom aspirin was thought to influence the development of allergic symptoms. A group of fifty allergic patients were questioned in detail regarding the use of aspirin and quinine, and in none was a hist,ory of allergic symptoms provoked by their use elicited. Five grains of aspirin were given to 103 consecutive patients at the clinic (after a negative history of aspirin sensitivity had been obtained), and the patients were obtained for two hours. None of the 103 patients reacted violently to the drug, although two asthmatic pat:ients complained of a feeling of slight chest constriction. Ninety-five allergists throughout the country were then circularized. Forty-six answered the questions regarding incidence of aspirin sensitivity. The average incidence based upon the answers received from this group was 0.2 per cent.
Dermatology UKDER
THE
DIRECTION
OF MAR.IO~V
JOSEPH
Skin
Hazards
Bulletin
No.
in American 249,
Industry.
Government
SULZBERGER,
GOODLIAN,
M.D.,
Part
Printing
III.
Office,
M.D.,
NEW
YORK,
AND
BOSTON
Schwartz, Washington,
L.: D.
Public C., 1939.
Health
This bulletin represents the third of a series of studies of skin hazards in American industry. The volume consists of eleven contributions dealing with skin hazards in the citrus fruit industry, cigar manufacture, acid manufacture, pulp and paper manufacture, iron and steel manufacture, and the manufacture of organic solvents, of chromic acid and chromates, of glass, and of explosives. In addition, there are considerations of skin hazards caused by paints, varnishes, and lacquers, as well as skin hazards in photography, printing, and allied trades. This bulletin and its two companions are indispensable for those interested in occupational dermatitis.
Sensitization Landsteiner,
to Picric K.,
and
Acid: DiSomma,
Subsidiary A. A.:
Agents J. Exper.
and Mode Med.
72:
361,
of Sensitization. 1940.
Previously published studies have dealt with the correlation of sensitization phen.omena with the relative lability of chemicals; the more labile the compound, the greater its sensitizing capacity. In this paper the authors have studies picric acid, a sulbstance which is chemically similar to the nitro compounds previously studied, but in which the NO, groups are not readily replaced. It was chosen because it was known to produce clinical sensitivity in the human being. In guinea pigs it was found that the application to the skin of dilute solutions of picric acid alone did not readily produce sensitivity. However, a more frequent sensitization was achieved by the use of butesin and picric acid (butesin picrate) or by the application of picric acid to an area which had been inflamed by the previous application of cantharides. A still greater degree of sensitization was achieved when butesin picrate was applied to the area previously treated with cantharides.
c