Subject index and author index

Neurobiology ofAging. Vol. 13, pp. Ill-V, 1992 Printedin the USA.All rightsreserved.

0197-4580/92 $5.00 + .00 Copyright© 1992PergamonPressLtd.

SUBJECT INDEX [3H]GBR 12935, 383 [ 14C]2-deoxy-D-glucose,687 4-hydroxy-3-methoxyphenylglycol (HMPG), 107 5-hydroxy-indoleacetic acid (5-HIAA), 107 HC-butanol, 747 HC-nicotine, 747 1,4-dihydropyridine, 73 ISF-fluoro-deoxy-glucose, 747 ISFDG, 723 Accumbens, 325 Acetylcholine, 313 Acetylcholinesterase histochemistry, 393 Acetylcholinesterase, 441,455,697 ACHE, 67 ACTH4-9 analog, 153 ACTH, 159, 227 AF64A, 25 Age associated memory impairment, 735 Age-induced plasticity, 217 Age-related deficit, 44 l Aged rat, 527 Aged, 231 Aggregation, 587 Aging, 1, 9, 39, 45, 51, 57, 63, 67, 73, 83, 89,93,99, 123, 131, 137, 145, 153, 159, 171, 175, 179,227,275, 293, 319, 369, 383, 393,401,405,435,475, 501, 505, 513,521,537,631,649, 661,681, 687, 705, 759, 773, 783, 787 ALS-PD, 333 Aluminum neurotoxicity, l 15 Alz 50, 537,613 AIz 50 staining, 561 Alzheimer's disease (AD), 1,25, 33, 93, 99, 107, 115, 137,239,255,261,267, 283, 301,313, 375, 393,405,413,421, 441,455,461,469, 483,493, 537,553, 569, 581,587, 591,605,609, 613, 631, 641,687,697, 711,723,747,793 Alzheimer's treatment, 735 Alzheimer, 179 Amphetamine, 123 Amygdala, 25 Amyloid deposits, 99 Amyloid precursor protein, 421,449 Amyloid/3-protein, 537, 553, 561,569, 581,587,591,595,605,609 Amyloid, 179, 469 Angiotensin II, 521 Animal models, 613 Aplysia, 217 Apnea, 741 Apomorphine, 175 APP secretion, 601 Arcuate nulceus, 275 Asparate, 705

Association cortex, 631 Astrocytes, 1 Astroglia, 239 Attention, 759 Axotomy, 231 B-Endorphin, 773 Basal forebrain, 67 Basal growth-hormone secretion, 255 Basement membrane, 137 Behavior, 83 Behavioral arousal, 123 Behavioral plasticity, 217 Beta amyloid fragments, 543, 577 Beta-protein, 595 Bioavailability, 333 Blessed dementia scale, 493 Blood-brain barrier permeability, 57 Blood-brain barrier, 137 BMAA, 333 Bradycardiac response, 123 Bradykinin, 33 Brain areas, 783 Brain atrophy, 717 Brain chromatin structure, 115 Brain gene regulation, 115 Brain metabolism, 723 Brain, 99, 521 Brain, 649 Brain, 747 Brown Norway, 319 Calcium, 33, 63 Carbachol, 521 Carboxyl-terminal fragments, 601 Catecholamines, 201 Cats, 231 Cell counting, 461 Cell death, 537 Cell loss, 461 Central nervous system, 513 Cerebellum, 89, 301,475 Cerebral cortex, 89, 705 Cerebral glucose utilization, 687 Cerebral metabolism, 93, 313 Cerebral microvessels, 137 Cerebrospinal fluid (CSF), 107, 261 CHAT, 67 Chlorodiazepoxide, 759 Cholesterol, 711 Choline acetyltransferase, 393, 441,527, 697 Cholinergic nerves, 293 Cholinergic system(s), 67, 553 Cholinergic, 735 Chromosome 21,723 Classical conditioning, 319 Clonidine, 255 Cognition, 63 Ill

Compensatory behavior, 217 Complement, 641 Computed x-ray tomography, 717 Cortex, 441,569, 641 Corticosterone, 159 CRH receptor, 227 CT scan, 723 Cycads, 333 Cytochromes, 361 Cytokines, 793 Cytoskeleton, 537 D2 receptors, 339,787 DAUC, 383 Degeneration, 201 Dementia, 483 Dementia, 71 I, 723 Denervation, 293 Densitometry, 275 Desensitization, 39 Development, 67 Diabetes mellitus, 717 Dietary restriction, 787 Dopamine release, 51 Dopamine, 339, 383, 505 Down syndrome, 137,723 Effects on memory, 40 I Elderly, 741 Electron microscopy, 711,773 Electron transfer, 361 Electrophysiology, 231 EMG, 319 Endothelin receptors and their subtypes, 513 Endotoxin, 605 Enhancement with glucose, 401 Entorhinal cortex, 283. 393, 405 Erections, 175 Estrous cycles, 787 Ethanolamine, 435 Excitotoxic lesions, 687 Excitotoxicity, 239 Fatty acids, 711 Female, 275 Fibroblasts, 33 Fischer 344, 319, 383 Fischer 344 rats, 513 Fluorescence histochemistry, 339 Forebrain cholinergic neurons, 9, 687 G protein, 293 GABA, 66 I GAP-43, 631 Gliosis, I Glucocorticoid receptor, 159 Glucocorticoids, 171 Glucose enhancement of memory, 401

INDEX

IV

Glucose, 401,717 Glutamate, 705 Glutamic acid, 239 Glutamine, 705 Glutathione, 361 GnRH, 68 l Growth-hormone-releasing hormone, 255 Guam, 333 Heat-shock, 661 Hemovanillie acid (HVA), 107 Hereditary Alzheimer's disease, 449 Hippocampal damage, 577 Hippocampal formation, 283 Hippocampal slice cultures, 543 Hippocampus, 131,293, 30I, 375, 393, 569, 581,641,697 Histochemistry, 455, 661 Histone Hlx, 115 HPLC, 649, 705 hsp70 mRNA, 661 Human cerebral cortex, 455 Human neurofilamentlight chain (HNFL) gene, 115 Human, 179, 649 Huntington'schorea, 301 Hybrid, 319 Hybridization, 661 Hyperglycemia, 717 Hypocaloric diet, 369 Hypopnea, 741 Hypothalamic-pituitary adrenal axis, 227 Hypothalamus, 681,773 Ibotenic acid lesions, 441 Immunocytoehemistry, 179, 201,773 Impotence, 175 In situ hybridization, 301,641 In vitro, 577 In vivo chronoamperometry, 325 In vivo, 577, 595 Indolamines, 201 Inflammation, 641 Inositol 1,4,5-trisphosphate, 89 inositol 1,3,4,5-tetrakisphosphate, 521 lnositol phosphate(s), 39, 505,521 Inositol, 52 I lnterneurons, 661 Ketanserin, 735 Kinase, 711 Learning and memory, 131 Learning, 57 Lectins, 137 Lemurian primate, 99 Lipopigment, 493 Lymphocytes, 421 Lysosomes, 493 M~ receptors, 25 Male rat, 681 Matrix, 501 Maturation, 435 Mecamylamine, 313 Median eminence, 275 Membrane, 711 Memory, 401 Mental retardation, 723 Message levels, 631

Messenger RNA secondar~ structure. 449 Methylazoxymethanol. 527 Microdensitometry, 501 Microglia, 641 Microglia, 793 Microparticles, 421 Microvasculature. 73 Mineralocorticoid receptor. 159 Molecular forms, 697 Monkeys, 561 Monoamine metabolism, 527 Monoamine metabolites, 107 Monoaminergic, 239 Morphology, 275 Morphometry, 73,405, 711 Morris water maze, 9 Motoneuron, 231 Motor cortex, 73 Motor learning, 475 Mouse, 773 Multi-infarct dementia, 711 Muscarinic cholinergic receptor, 39, 45 Muscarinic receptor(s), 25, 51,293 Myelinaled fibers, 73 Neostriatum, 501 Nerve conduction velocity, t 53 Neural membrane structure and composition, 413 Neuritic plaques, 1 Neurochemistry, 201 Neu rodegeneration, 591 Neurofibrillary charges, 99 Neurofibrillary tangle, 179, 63 I Neuroimmunology, 793 Neuronal cultures, 435 Neuropathology, 469 Neurophysins, 261 Neuropil threads, 179 Neuropsychotogy, 723 Neurotoxicity, 537, 569, 581,587,609 Neurotransmitter interaction, 735 Neurotrophic factors, 1 Nicotinic receptors, 747 Nictitating membrane, 319 Nigrostriatal system, 339 Nimodipine, 63, 73 Nonspatial learning, 369 Norepinephrine, 475 NT75, 283 Nucleus basalis magnoceUularis,25,687 Nucleus raphes dorsalis, 461 Nucleus, 325 Olfactory system, 469 Overflow, 325 Oxytocin, 261,783 Paired helical filament(s), 179, 267 Parietal cortex, 697 Peptide conformation, 609 Peptides, 649 Perforant path lesion, 649 Perforant pathway, 283,405 Performance, 353 Pergolide, 339 Permeability-capillary surface area products, 57 Peroxidative stress, 361 PET scan, 723, 747

Phosphatidylserine. 45 Phosphoethanolamine N-methylation, 435 Phosphoinositides. 505 Phospholipase C, 293 Physostigmine, 735 Piracetam, 39 Pituitary dopamine. 787 Plasma. 783 Platelets, 421 Point mutations, 449 Polymyxin B, 605 Positron emission tomography, 93 Postmortem delay, 649 Postnatal development, 89 Potassium, 325 Predictability of behavior, 145 Prefrontal cortex, 131 Preoptic area, 681 Presynaptic marker, 383 Primate(s), 333,537 Prolactin axis, 275 Prolactinoma, 275 Protease nexin-ll, 421 Protein kinase C, 711 Protein phosphrylation, 601 Protein. 537. 649 Proteoglycan, 239 Purjinje cell, 89 Push-pull perfusion, 705 Pyramidal cortical neurons, 99 Pyramidal neurons. 455 Quantitative autoradiography, 383 Radial water maze, 369 Rat brain, 159, 435, 505 Rat hippocampal cultures, 605 Rat hippocampos. 661 Rat strains, 227 Rat(s), 57, 63, 145, 153, 275,283, 369, 441,537, 595, 687, 783 Recent memory, 63 Reference memory, 369 Regional cerebral blood flow, 313, 483 Reproduction, 773 Restricted diet, 369 Rodent, 649 S 100~, 1 SCH23390, 505 Sciatic nerve, 73 Scopolamine, 313, 759 Second messengers, 521 Senile plaques, 99, 393 Septal nucleus, 697 Sequencing, 649 Serotonergic, 735 Serotonin, 83 Single units, 661 SKF38393, 505 Sleep-disordered breathing, 741 Sleepiness, 353 Somatostain-analogue SMS 201-995, 255 Sociability, 145 Social attention, 153 Somatostatin, 255 Spatial learning, 153, 369, 661 Spatial memory, 9 SPECT, 483 Spontaneous activity, 527

INDEX Stereology. 461 Stone maze, 57 Stress, 123, 159, 171,319,661 Striatum. 51,325,339,581,787 Striosomes. 501 Substance P, 591 Substantia innominata. 697 Substantia nigra, 339 Synapses, 375.405 Synaptic mitochondria, 361 Synaptology, 681 Synaptophysin. 283. 375 Tachykinin, 239 Tacrine, 747

V Tau protein. 267 Tau, 537 Temporal cortex, 301 Temporal lobe, 1,483 Thioflavin-S, 179 Thrombocyte, 711 Thyroid hormone receptor, 301 Toxicity, 595 Tuberoinfundibulardopaminergic neurons, 275 Tyrosine hydroxylase, 275 Ubiquitin, 179 Ultrastructure, 73 Ultrastructure, 681

Uptake, 325 Use-disuse. 217 Vasopressin, 261 Vigilance, 353 Vigilance, 759 Viral infection, 83 Working memory.. 369 X-ray diffraction, 413 Zinc, 501 ZK939 426, 759

Neurobiologyof Aging, Vol. 13, pp. VII-IX, 1992 Printed in the USA. All rights reserved.

0197-4580/92 $5.00 + .00 Copyright© 1992 PergamonPress Ltd.

AUTHORINDEX Adams, K., 577 Aguilera, G., 227 Aletrino, M. A., 461 Algeri, S., 369 Altman, H. J., 57, 735 Amberla, K., 747 Amenta, F., 501 Anderson, C., 787 Andriamampandry, C., 435 Angignard, D., 527 Argiolas, A., 783 Armstrong, D. M., 67 Aronson, M. K., 179 Aschmies, S., 591 Baker, M. G., 483 Baronti, F., 255 Bartholomeus, 1. G. P., 711 Beal, M. F., 537 Becker, G. W., 605 Benzi, G., 361 Bergeron, C., 115,301 Berman, R. F., 57 Bertelsen, G. A., 513 Bestetti, G. E., 275 Bickford, P., 475 Bj6rklund, A., 9 Bjurling, P., 747 Blau, A. D., 179 Blennow, K., 107 Bohus, B., 123 Bonnet, M., 527 Boris, N., 99 Bonshek, R. E., 137 Borchelt, D. R., 623 Borden, L. A., 33 Borzeix, M. G., 527 Bosman, G. J. C. G. M., 711 Brosius, J., 449 Brown, A. M. T., 137 Brown, A., 393 Brunner, W. F., 267 Bruno, J. P., 759 Bryant, K., 569 Busciglio, J., 609 Buwalda, B., 123 Buxbaum, J. D., 601 Buysse, D. J., 353, 741 Cabalka, L. M., 283 Cairns, M. R., 493 Caporaso, G. L., 601 Caputo, C. B., 267 Celi, A., 421 Chambers, T. E., 413 Charles, Ph., 527 Chase, M. H., 231 Chase, T. N., 255 Chen, K. S., 9

Chin, D., 421 Clark, H. B., 469 Clemens, J. A., 339, 561,581 Cobo, M., 705 Cole, G. M., 595 Coleman, P. D., 197, 535, 631 Connor, D. J., 595 Copani, A., 587 Cotman, C. W., 587 Court, J. A., 393 Crapper McLachlan, D. R., 115, 301 Crews, F. T., 521 Crystal, H. A., 179 Curti, D., 361 Dagani, F., 361 Davies, P., 179, 375, 613 Davis, D. L., 569 Dawson, V. L., 25 De Grip, W. J., 711 de Jong, G. I., 73 de Kloet, E. R., 159 De La Garza, R., 475 De Micheli, E., 687 Degennaro, L. J., 405 Dickson, D. W., 179, 375, 793 Dowson, J. H., 493 Drachman, D. A., 405 Dreyfus, H., 435 Dudchenko, P., 759 Duncan, M. W., 333 Dupont, J. M., 527 Eberling, J. L., 483 Emre, M., 553 Engelhardt, J. K., 231 Eskin, T., 631 Exposito, I., 705 Fasth, K.-J., 747 Felten, D. L., 339 Felten, S. Y., 339 Finch, C. E., 641 Finch, C. E., 787 Fischer, W., 9 Flood, D. G., 649 Fonnum, F., 83 Fratta, W., 783 Frautschy, S. A., 595 Frederickson, R. C. A., 239 Freysz, L., 435 Friedemann, M. N., 325 Friedman, E., 505 Frosch, M. P., 561 Fuller, R. W., 339 Furie, B. C., 421 VII

Gage, F. H., 9, 67 Games, D., 569 Gandy, S. E., 601 Gaykema, R. P. A., 441 Gelbmann, C. M., 45 Gerhardt, G. A., 325,475 Gershon, S., 57 Geula, C., 455,553 Gilad, G. M., 227 Gilbertson, E., 67 Gispen, W. H., 73 Gitelm~n, D. R., 313 Gitter, B. D., 605 Gleeson, J., 375 Gold, P. E., 401 Goldman, H., 57 Goldman, J. E., 33 Goodlett, C. R., 283 Gottfries, C. G., 107 Grady, C. L, 723 Green, M. A., 89 Greengard, P., 601 Greiner, P. O., 527 Griffin, W. S. T., 1 Grond, M., 93 Groshan, K., 661 Gulati, A., 513 Haass, C., 42 I Hall, F., 741 Hallahan, B. J , 217 Hamos, J. E., 405 Handley, P., 301 Harbaugh, R., 261 Harrington, L. S., 697 Hartvig, P., 747 Haxby, J. V., 723 Heaton, J. P. W., 175 Hecker, L. I., 421 Heckers, S., 455 Heiss, W.-D., 93 Helkala, E.-L, 717 HeUstrom-Lindahl, E., 747 Herbette, G., 413 Herholz, K., 93 Herold, M., 527 Heron, C., 475 Hersh, L. B., 441 Heuser, 1. J. E., 255 Hoch, C. C., 353, 741 Honer, W. G., 375 Horvath, E., 73,441 Hu, Y., 333 Hunt, M. E., 25 Hyman, B. T., 283 lnce, P. G., 393 Inglefield, J. R., 383

VIII Jagust, W. J., 483 Jansen, A. S. P., 73 Jennings, J. R., 353 Johansson, M., 747 Johnson, M., 393 Johnson, S. A., 641 Jones, D., 137 Joseph, J. A., 51 Kanfer, J. N., 435 Karlsson, I., 107 Kazee, A. M., 631 Keim, P. S., 569 Kerwin, J. M., 393 Kessler, J., 93 Khachaturian, Z., 197 Khan, K. M., 569 Kohama, S. G., 787 Konings, D., 449 Kopin, 1. J., 333 Kosik, K., 535 Kowall, N. W., 537 Ktishnan, B., 115 Kristensson, K., 83 Kruck, T. P. A., 115 Kupfer, D. J., 353, 741 Kurian, P., 521

.~UTHOR INDEX Mesulam, M.-M., 455, 5~3 Mielke, R., 93 Miller, M. M.. 773 Mizumori, S. J., 673 Mohammed, A. K. H., 83 Monk, T. H., 353 Montejo De Garcini, E., 267 Moore, H. J., 759 Mora, F., 705 Morales, F. R., 231 Morehead, M., 57 Morrison-Bogorade, M., 661 Mountjoy, C. Q., 493 Mouradian, M. M., 255 MiJller, W. E., 39, 45 Murphy, S., 57 Nairn, A. C., 601 Narang, N., 521 Neilsen, S., 697 Nordberg, A., 747 Normile, H. J., 735 Norris, T. E., 267 North, W. G., 261 Novak, M., 267 Nyakas, C., 123. 441 Ostaszewski, B. L., 421

Laakso, M., 717 Lampert-etchells, M., 641 Langstrom, B., 747 Lapham, L., 631 Lekman, A., 107 Levere, T. E., 63 Li, P. P., 89 Lieberburg, 1., 42 I, 56 I, 569 Lilja, A., 747 Lippa, C. F., 405 Liskowsky, D, R,, 293 Lo, M. M. S., 267 Lorenzo, A., 609 Luiten, P. G. M., 73, 123, 441 Lukiw, W. J., 115 Lundqvist, H., 747 Ma, N., 255 Machen, M. A., 353 Machen, M., 741 Maehlen, J., 83 Magnusson, O., 83 Majtenyi, C., 441 Malouf, A. T., 543 Mancini, M., 501 Mann, D. M. A., 137 Matin, C. A., 255 Markey, S. P., 333 Marshak, D. R., 1 Marzatico, F., 361 Mason, R. P., 413 Massarelli, R., 435 Masur, D. M., 179 Mattiace, L. A., 179 Mattson, M. P., 617 Maxfield, F. R., 33 May, P. C., 605,787 McKee, A. C., 537 Melenhorst, J. J., 711 Melis, M, R., 783 Merriam, G. R., 255 Merriman, M. C., 591 Mestre, N., 99

Pardue, S., 661 Parsons, M. W., 401 Pasinetti, G. M., 641 Pastotis, O., 361 Peacock, J. H., 697 Pearce, B. D., 293 Pearson, P. G., 333 Peretz, B., 217 Perry, E. K., 393 Perry, R. H., 393 Pesce, S. A., 1 Petter, A., 99 Piggott, M. A., 393 Pike, C. J., 587 Pitsikas, N., 369 Podlisny, M. B., 561 Porras, A., 705 Potter, L. T., 293 Price, D. L., 623 Prohovnik, !., 313 Pulaski-Salo, D., 405 Puranen, M., 717 Purkiss, M. S., 137 Raese, J. D., 661 Ramabhadran, T. V., 601 Ransil, B. J., 553 Rebello, S., 513 Reed, B. R., 483 Reeder, T_, 261 Reymond, M. J., 275 Reynolds, !I1, C. F., 353, 741 Ricci, A., 501 Richfield, E. K., 383 Riekkinen, P. J., 717 Ritchie, T. C., 283 Robison, P. M., 605 Rogers, J., 793 Rogers, K., 631 Romano, T. D., 339 Rossi, G. L., 275 Roth, G. S., 51 Rots, N. Y., 159

Rozovsky, I., 64 I Rush, D. K., 591 Rydel, R. E., 617 Salama. A. I., 267 Salo, D., 787 Sapolsky, R. M., 171,577 Sarter, M., 759 Schapiro, M. B., 723 Schegg, K. M., 697 Schlernitzauer, M., 741 Schlossmacher, M.. 42 l Schubert, T., 39 Schuurmans Stekhoven, J. H.,711 Scott, C. W., 267 Selkoe, D. J., 421, 561 Shajenko, L., 413 Shaw, P. J., 393 Shelanski, M. L., 33 Shoemaker, W. J., 413 Simmons, L. K., 605 Sisodia, S. S., 623 Skinner, T. L., 217 Skoog, I., 107 Slemmon, J. R., 649 Small, J. S., 605 Smalstig, E. B., 339 Soininen, H., 717 Somerville, M. J., 301 Soncrant, T. T., 687 Soriano, F. G., 569 Spruijt, B. M., 145, 153 Stancampiano, R., 783 Stanley, L. C.. 1 Stein-Behrens, B., 577 Steinbusch, H. W. M., 201 Stephenson, D. T., 561,581 Stoddart, R. W., t 37 Stoll, L., 39 Struble, R. G., 469 Sutanto, W., 159 Sutherland, M. K., 301 Suzuki, T., 601 Svennerholm, L., 107 Telford, N., 787 Ten Donkelaar, H. J., 461 Thai, L. J., 67, 595 Thompson, R. F., 319 Tizabi, Y., 227 Tonnaer, J. A. D. M., 201 Undie, A. S., 505 Van Domburg, P. H. M. F., 461 van Eekelen, J. A. M., 159 Van Hoesen, G. W., 283 Van Kalmthout, P. J. C., 711 Van Luijtelaar, M. G. P. A., 201 Van Zuylen, A. J., 711 Varrin, S., 175 Vecil, G. G., 89 Viitanen, M., 747 Villa, R. F., 361 Vogels, O. J. M., 461 Waite, J., 595 Walford, R. L., 787

AUTHORINDEX Walker, A., 63 Walker, L. C., 623 Wallin, A., 107 Wamsey, J. K., 25 Warpman, M., 747 Warsh, J. J., 89 Waters, D. C., 605 Weick, B. G., 333 Weindruch, R., 787 Weiss, C., 319

IX Wilton-Cox, H., 493 Winblad, B., 747 Winocur, G., 131 Wischik, C., 267 Witkin, J. W., 681 Wong, D. T., 339 Wong, L., 115, 301 Yamagami, K., 51 Yamuy, J., 231

Yankner, B. A., 537, 609, 615 Yeh, M., 577 Yen, S.-H., 179 Yoong, L., 301 Young, D. A., 475 Zhu, L., 773 Ziffer, H., 333 Zweig, R. M., 697