Subject index for volume 93

TOXICOLOGY

AND

APPLIED

PHARMACOLOGY

93,s 15-522

(1988)

Subject Index for Volume 93 Autoradiography whole-body, [‘Hfphencyclidine (mouse), 42 1

A

Acetaminophen hepatic and respiratory toxicity, protective effects of dimethyl sulfoxide (mouse), 452 inhibition of hepatic mitochondrial respiration (mouse),

and metabolites

B

378

Acetazolamide in pharmacologic probing of amphotericin B-induced renal dysfunction (neonatal rat), 360 Administration route inhalation, effects of pulmonary metabolism on xenobiotic fate, 484 a*-Adrenoceptors interaction with formamidine pesticides: in vitro and in vivo studies (murine brain), 3 19 Aflatoxin B, hepatotoxicity, protection by oltipraz (rat), 442 Amiloride in pharmacologic probing of amphotericin B-induced renal dysfunction (neonatal rat), 360 Amitraz interaction with cYr-adrenoceptors: in vitro and in vivo studies (murine brain), 3 19 Amoxapine high concentrations, inhibition of mitochondrial electron transport, biochemical evidence (bovine, rat, yeast), 1 18 Amphotericin B induced renal dysfunction, pharmacologic probing (neonatal rat), 360 Announcements International Symposium on Chemical Mixtures: Risk Assessment and Management, Cincinnati, Ohio, June 1988,5 12 Kenneth Morgareidge Award, 5 12 Second Meeting of the International Neurotoxicology Association, Barcelona, Spain, May 1989,5 I 1 Toxicology Update ‘88: Current Concepts in Reproductive Toxicology, Baltimore, Maryland, June 1988,511 Ascorbate dietary, effect on N-mononitrosopiperazine excretion after low-level piperazine inhalation exposure (human), 28 1 Astrocytes cerebral, diethyldithiocarbamate cytotoxicity, glutathione protective effects, mechanism (rat), 154 ATPase Na,K-transporting, inhibition by lead ion in vitro, analysis in model system: effects of low level [Pb] and modulation by homogenate (rat), 101

Behavior motor activity, effects of hexachlorocyclohexane isomers (mouse), 146 Benzo(a]pyrene modulation of immunocompetent cell populations (mouse), 267 Benzo[a]pyrene hydroxylase distribution in nasal mucosa, trachea, and lung analysis (rat), 493 o-Benzoquinone reactions associated with catechol oxidation by horseradish peroxidase and human leukocyte peroxidase, analysis, 62 o-Benzosemiquinone reactions associated with catechol oxidation by horseradish peroxidase and human leukocyte peroxidase, analysis, 62 Bile excretion of glutathione-related thiols and methyl mercury, species variation (guinea pig, hamster, mouse, rabbit, rat), 35 1 Bile duct lining cells, early changes after a-naphthylisothiocyanate treatment (rat), 208 N,N-Bis(l-methylethyl)-4-methyl-3-oxo-4-aza-5aandrostane- 17&carboxamide hepatotoxicity, role of cytochrome P-450 in detoxication (rat), 403 N,N-Bis(1 -methylethyl)-3-oxo-4-aza-5~-androstane17j3-carboxamide hepatotoxicity, role of cytochrome P-450 in detoxication (rat), 403 Blood pressure elevation associated with low-level lead exposure, analysis (dog), 388 Brain Lu2-adrenoceptors, interaction with formamidine pesticides: in vitro and in vivo studies (mouse), 3 19 cation pump enzyme, in vitro inhibition by lead ion: effects of low [Pb] level and modulation by homogenate (rat), 10 1 Bromobenzene toxicity and biotransformation, effects of long-term streptozotocin diabetes (rat liver), 329

515

0041-008X/88$3.00 Copyright 0 1988 by Academic F’res, Inc. All rights of reproduction in any form resewed

516

SUBJECT INDEX

Cadmium testicular toxicity, associated resistance and susceptibility, strain dependence: role of testicular cadmium-binding proteins (mouse), 47 Calcium intracellular, increase in polymorphonuclear leukocytes, stimulation by chlordane (guinea pig), 137 Carbon disulfide hepatotoxicity, metabolism, and distribution, role of ethanol-inducible cytochrome P-450 (rat), I 1 Carbon tetrachloride induced hepatic tissue oxidation reactions, detection in viva by “0 tracing (rat), 8 1 metabolism in viva, effects of pretreatment with chlordecone, mirex, or phenobarbital (rat), 247 toxicity and biotransformation, effects of long-term streptozotocin diabetes (rat liver), 329 Catechol, see Pyrocatechol Central nervous system biochemical and pharmacological effects of hexachlorocyclohexane isomers (mouse), 146 Chinese hamster ovary cells growth, differentiation, and chromatin structure, hydralazine effects, 339 Chlordane cis and tram isomers, stimulative effects on leukocyte function (guinea pig), 137 Chlordecone effect of pretreatment on carbon tetrachloride in vivo metabolism (rat), 247 Chlordimeform interaction with cYz-adrenoceptors: in vitro and in viva studies (murine brain), 3 19 Chlorothiazide in pharmacologic probing of amphotericin B-induced renal dysfunction (neonatal rat), 360 Chromatin structure, hydralazine effects(mammalian cells), 339 Cromolyn sodium effectson ozone-induced changes in lung function and plasma eicosanoid levels (guinea pig), 175 Cysteine and other glutathione-related thiols and methyl mercury, biliary excretion, species variation (guinea pig, hamster, mouse, rabbit, rat), 35 I Cysteine disulfide glutathione-mixed, and other glutathione-related thi01sand methyl mercury, biliary excretion, species variation (guinea pig, hamster, mouse, rabbit, rat), 351 Cysteinylglycine and other glutathione-related thiols and methyl mercury, biliary excretion, species variation (guinea pig, hamster, mouse, rabbit, rat), 35 I

Cystine and other glutathione-related thiols and methyl mercury, biliary excretion, species variation (guinea pig, hamster, mouse, rabbit, rat), 35 1 Cystinylglycine disulfide and other glutathione-related thiols and methyl mercury, biliary excretion, species variation (guinea pig, hamster, mouse, rabbit, rat), 35 1 Cytochrome P-450 BNF-B, MC-B, PB-B, and PCN-E isozymes, bioactivation and detoxication of xenobiotics within nasal mucosa, trachea, and lung (rat), 493 ethanol-inducible isozyme, role in carbon disulfide hepatotoxicity, metabolism, and distribution (rat), 1 1 pulmonary, genetically inducible, nitrogen dioxide toxicity, fl-naphthoflavone protective effect (mouse), 220 role in detoxication of nitrogen-containing steroids (rat), 403 D

Desmethylchlordimeform interaction with a*-adrenoceptors: in vitro and in vivo studies (murine brain), 3 19 Diabetes long-term streptozotocin-induced, effects on bromobenzene and carbon tetrachloride toxicity and biotransformation (rat liver), 329 Diet ascorbate- and nitrate-supplemented, effectson N-mononitrosopiperazine excretion after low-level piperazine inhalation exposure (human), 28 1 Diethyldithiocarbamate cytotoxicify, glutathione protective effects, mechanism (rat cerebral astrocytes), 154 N,N-Diethyl-4-methyl-3-oxo-4-aza-5~-androstane17@carboxamide hepatotoxicity, role of cytochrome P-450in detoxication (rat), 403 N,N-Diethyl-4-methyl-3-oxo-4-aza-5~-androst-l-ene17/3-carboxamide hepatotoxicity, role of cytochrome P-450in detoxication (rat), 403 N,N-Diethyl-3-oxo-4-aza-5a-androstane-l7flcarboxamide hepatotoxicity, role of cytochrome P-450in detoxication (rat), 403 N,N-Diethyl-3-oxo-4-aza-Sa-androstI-ene- 17@carboxamide hepatotoxicity, role of cytochrome P-450in detoxication (rat), 403 Differentiation mammalian cells, hydralazine effects,339 Diisopropyl fluorophosphate, see Isoflurophate

SUBJECT INDEX 7,12Dimethylbenz[a]anthracene suppression of splenic lymphocyte function in vitro (mouse), 369 Dimethylmercury and glutathione-related thiols, biliary excretion, species variation (guinea pig, hamster, mouse, rabbit, rat), 35 1 Dimethyl sulfoxide protection against acetaminophen-induced hepatic and respiratory toxicity, analysis (mouse), 452 Dioxin related effectsofoctachlorodibenzo-pdioxin after subchronic exposure (rat), 3 1 Diquat effect on iron distribution in liver (rat), 506 toxicity, relationship to intracellular vitamin E and lipid peroxidation (rat hepatocytes), 288 Disposition gentamicin, morphine effects (mouse), 4 13 [3H]phencyclidine, analysis by whole-body autoradiography (mouse), 42 1 inhaled materials, effects of respiratory tract metabolism, 484 iron in liver, diquat effects(rat), 506 2-methoxyethanol, relationship to embryotoxicity (mouse), 195 octachlorodibenzo-p-dioxin after single and repeated exposure, analysis (rat), 22 2,3,4,7,8-pentachlorodibenzofuran after iv exposure, analysis (rhesus monkey), 23 1 subcellular, mercury in renal cortex after unilateral nephrectomy, analysis (rat), 187 DNA hepatic and pulmonary, interaction with methylene chloride after inhalation exposure (mouse, rat), 1 E

Editorial note publication of symposia proceedings, 462 Electron transport mitochondrial, inhibition by amoxapine, biochemical evidence (bovine, rat, yeast), 118 Embryotoxicity 2-methoxyethanol, relationship to disposition (mouse), 195 Epithelial cells alveolar type II, purification, properties, and functions (rat), 472 bile duct-lining, early changes after ol-naphthylisothiocyanate treatment (rat), 208 tracheal, adaptation to ozone toxicity after prolonged exposure, in vitro evidence (rat), 394 Epoxide hydrolase bioactivation and detoxication of xenobiotics within nasal mucosa, trachea, and lung (rat), 493

517

Ethanol effect on carbon disulfide metabolism and distribution, role of ethanol-inducible cytochrome P-450 (rat), 11 Excretion biliary, glutathione-related thiols and methyl mercury, species variation (guinea pig, hamster, mouse, rabbit, rat), 35 1 mercury after unilateral nephrectomy, analysis (rat), 187 N-mononitrosopiperazine after low-level piperazine inhalation exposure, effects of dietary nitrate and ascorbate (human), 28 1 F

Furosemide in pharmacologic probing of amphotericin B-induced renal dysfunction (neonatal rat), 360 G

Gentamicin disposition and toxicity, effects of morphine (mouse), 413 Glutathione protective effects on diethyldithiocarbamate cytotoxicity, mechanism (rat cerebral astrocytes), 154 and related thiols and methyl mercury, biliary excretion, species variation (guinea pig, hamster, mouse, rabbit, rat), 35 1 Glutathione Stransferase hepatic, activation by nonsubstrate ligands, characterization (rat), 275 types B, C, and E, bioactivation and detoxication of xenobiotics within nasal mucosa, trachea, and lung (rat), 493 Growth mammalian cells, hydralazine effects,339 H

Heart mitochondrial electron transport, inhibition by high amoxapine concentrations, biochemical evidence (bovine), 118 Hepatocytes, see also Liver early changes after cu-naphthylisothiocyanate treatment, analysis (rat), 208 intracellular vitamin E, lipid peroxidation, and chemical toxicity, relationship (rat), 288 nitrogen-containing steroid toxicity, role of cytochrome P-450 in detoxication (rat), 403 Heptachlor stimulative effect on leukocyte function (guinea pig), 137

SUBJECT INDEX

518

Heptachlor epoxide stimulative effect on leukocyte function (guinea pig), 137 Hexachlorocyclohexane, see Lindane Horseradish peroxidase catechol oxidation, o-benzoquinone and o-benzosemiquinone reactions, 62 Hydralazine effectson cellular growth, differentiation, and chromatin structure (mammalian cells), 339 Hydronephrosis association with postnatal exposure to methyl palmoxirate (rat), 127

Immune responses mononuclear leukocytes, benzo[a]pyrene-induced modulation (mouse), 267 Immunotoxicity 7,12-dimethylbenz[a]anthracene, effect on splenic lymphocyte function in vitro (mouse), 369 Indomethacin effects on ozone-induced changes in lung function and plasma eicosanoid levels (guinea pig), 175 Inhalation toxicity effectsof respiratory tract metabolism, 484 ozone, cellular adaptation in trachea after prolonged exposure, in vitro evidence (rat), 394 piperazine, N-mononitrosopiperazine excretion after low-level exposure, effects of dietary nitrate and ascorbate (human), 281 Iron distribution in liver, effect ofdiquat (tat), 506 Iron nitrilotriacetate induction of autoxidative tissue damage (mouse, rat), 89 Isobutyl alcohol effect on carbon disulfide metabolism and distribution, role of ethanol-inducible cytochrome P-450 (rat), 11 Isoflurophate effect on muscarinic receptor binding number in pheochromocytoma PC12 cells (rat), 257 Isopropyl alcohol effect on carbon disulfide metabolism and distribution, role of ethanol-inducible cytochrome P-450 (rat), 11 K

Kidney dysfunction, amphotericin B-induced, pharmacologic probing (neonatal rat), 360 hydronephrosis, association with postnatal exposure to methvl- oalmoxirate frat). . II 127 -

iron nitrilotriacetate-induced autoxidative damage, analysis (mouse, rat), 89 mercury content and cortical subcellular distribution, effectsof unilateral nephrectomy (rat). 187

Lactofen induction of hepatic peroxisomal proliferation (mouse), 72 Lead induction of elevation in blood pressure during lowlevel exposure (dog), 388 inhibition of cation pump enzyme in vitro, effects of low [Pb] level and modulation by homogenate (rat brain), 101 Leukocytes mononuclear, immunocompetence, modulation by benzo[u]pyrene (mouse), 267 polymorphonuclear, see Neutrophils Lindane (Y,6, and y isomers, biochemical and pharmacological effectson central nervous system (mouse), 146 Lipids peroxidation, relationship to intracellular vitamin E and chemical toxicity (rat hepatocytes), 288 Liver, see also Hepatocytes acetaminophen toxicity, protective effects of dimethyl sulfoxide (mouse), 452 aflatoxin Bi toxicity, protective effects of oltipraz (rat), 442 bromobenzene and carbon tetrachloride toxicity and biotransformation, effectsof long-term streptozotocin-induced diabetes (rat), 329 carbon disulfide toxicity, metabolism, and distribution. role of ethanol-inducible cytochrome P-450 (rat), 11 carbon tetrachloride-induced oxidation reactions, detection in vivo by “0 tracing (rat), 8 1 DNA and proteins, interaction with methylene chloride after inhalation exposure (mouse, rat), 1 iron nitrilotriacetate-induced autoxidative damage, analysis (mouse, rat), 89 microsomal electron transport system, inhibition by high amoxapine concentrations, biochemical evidence (rat), 118 mitochondrial respiration, acetaminophen-induced inhibition (mouse), 378 peroxisome proliferation, induction by lactofen (mouse), 72 Lung alveolar macrophages, stimulation of neutrophil and monocyte migration, effects of in vitro ozone exposure (rabbit), 3 12 alveolar type II epithelial cells, purification, properties, and functions (rat), 472

SUBJECT INDEX DNA, interaction with methylene chloride after inhalation exposure (mouse, rat), 1 N-methylthiobenzamide toxicity, role of serotonin (rat), 165 nitrogen dioxide toxicity, protective effects of /3-naphthoflavone in mice with genetically inducible cytochrome P-450,220 ozone-induced functional changes, effects of indomethacin and cromolyn sodium (guinea pig), 175 pyrrolizidine poisoning, role of platelets (rat), 463 xenobiotic activation and detoxication: implications for chemically induced toxicity (rat), 493 Lymphocytes growth, differentiation, and chromatin structure, hydralazine effects(mouse), 339 splenic, function, suppression by 7,12-dimethylbenz[a]anthracene in vitro (mouse), 369 M

Macrophages alveolar, stimulation of neutrophil and monocyte migration, effectsof in vitro ozone exposure (rabbit), 312 Membrane potential polymorphonuclear leukocytes, alteration by chlordane (guinea pig), 137 Menadione toxicity, relationship to intracellular vitamin E and lipid peroxidation (rat hepatocytes), 288 Mercury tissue content, urinary excretion, and renal cortical subcellular distribution, effects of unilateral nephrectomy (rat), 187 Metabolism carbon tetrachloride in vim, analysis after pretreatment with chlordecone, mirex, or phenobarbital (rat), 247 in respiratory tract, effect on fate of inhaled materials, 484 Metallothionein role in strain dependence of resistance and susceptibility to cadmium testicular lesions, analysis (mouse), 47 Methanol effect on carbon disulfide metabolism and distribution, role of ethanol-inducible cytochrome P-450 6-4, 11 2-Methoxyethanol disposition, relationship to embryotoxicity (mouse), 195 Methylene chloride macromolecular interactions in liver and lung after inhalation exposure, analysis (mouse, rat), 1 Methyl mercury, see Dimethylmercury

519

Methyl palmoxirate association with hydronephrosis after postnatal exposure (rat), 127 1-Methyl-4-phenylpyridinium ion toxicity, relationship to intracellular vitamin E and lipid peroxidation (rat hepatocytes), 288 1-Methyl-4-phenyl- 1,2,3,6-tetrahydropyridine toxicity, relationship to intracellular vitamin E and lipid peroxidation (rat hepatocytes), 288 N-Methylscopolamine ‘H-labeled, muscarinic receptor binding in pheochromocytoma PC12 cells, effects of organophosphates and nerve growth factor (rat), 257 N-Methylthiobenzamide pneumotoxicity, role of serotonin (rat), 165 Microsomes hepatic, electron transport system, inhibition by higb amoxapine concentrations, biochemical evidence (rat), 118 Mirex effect of pretreatment on carbon tetrachloride in vivo metabolism (rat), 247 Mitochondria electron transport, inhibition by amoxapine, biochemical evidence (bovine, rat, yeast), 118 hepatic, respiration, acetaminophen-induced inhibition (mouse), 378 Models mathematical, for risk of death by oxygen toxicity: modulation by intermittent exposure (guinea pig), 298 Monocrotaline pulmonary poisoning, role of platelets (rat), 463 Monocytes migration, alveolar macrophage-stimulated, effects of in vitro ozone exposure (rabbit), 3 12 A’-Mononitrosopiperazine excretion after piperazine low-level inhalation exposure, effects of dietary nitrate and ascorbate (human), 28 1 Morphine effectson gentamicin disposition and toxicity (mouse), 413 Mucosa nasal, xenobiotic activation and detoxication: implications for chemically induced toxicity (rat), 493 Muscarinic receptors in pheochromocytoma PC 12 cells, binding to [‘H]Nmethylscopolamine, effects of organophosphates and nerve growth factor (rat), 257 N

NADPH-cytochrome P-450 reductase bioactivation and detoxication of xenobiotics within nasal mucosa, trachea, and lung, analysis (rat), 493

520

SUBJECT INDEX

fl-Naphthoflavone protective effect against nitrogen dioxide toxicity in mice with genetically inducible pulmonary cytochrome P-450,220 a-Naphthylisothiocyanate induced early changes in bile duct-lining cells and hepatocytes, analysis (rat), 208 Nephrectomy unilateral, effectson mercury handling and renal cortical subcellular distribution (rat), 187 Nerve growth factor effect on muscarinic receptor binding number in pheochromocytoma PC 12 cells (rat), 257 Neurotoxicity diethyldithiocarbamate, protective effects of glutathione (rat cerebral astrocytes), 154 formamidine pesticides, role of cY2-adrenoceptors, in vitro and in vivo studies (murine brain), 3 19 hexachlorocyclohexane isomers, evaluation (mouse). 146 peripheral, induction by chronic vincristine treatment (rabbit), 433 Neutrophils migration, alveolar macrophage-stimulated, effects of in vitro ozone exposure (rabbit), 3 12 various functions, stimulative effects of chlordane and related compounds (guinea pig), 137 Nitrate dietary, effect on N-mononitrosopiperazine excretion after low-level piperazine inhalation exposure (human), 28 1 Nitrogen containing steroids, hepatotoxicity, role of cytochrome P-450 in detoxication (rat), 403 Nitrogen dioxide toxicity in mice with genetically inducible pulmonary cytochrome P-450, fl-naphthoflavone protective effect, 220 pNitrophenylphosphatase K+-, inhibition by in vitro lead ion: effectsof low [Pb] level and modulation by homogenate (rat), 101 Nose mucosa, xenobiotic activation and detoxication: implications for chemically induced toxicity (rat), 493 0

Octachlorodibcnzo-pdioxin accumulation and toxic effects after subchronic exposure, analysis (rat), 3 1 disposition after single and repeated exposure, analysis (rat), 22 Oltipraz protective effects against aflatoxin B, hepatotoxicity (rat), 442

Oxidation carbon tetrachloride-induced, in hepatic tissue, detection by in vivo “0 tracing (rat), 8 1 catechol, by horseradish peroxidase and human leukocyte peroxidase: o-benzoquinone and u-benzosemiquinone reactions, 62 fatty acid, inhibitor methyl palmoxirate, association with hydronephrosis after postnatal exposure (rat), 127 Oxygen hyperbaric, pulmonary and central nervous system toxicity, modulation by intermittent exposure (guinea pig), 298 Oxygen- 18 tracing in detection of carbon tetrachloride-induced oxidation reactions in hepatic tissue (rat), 8 1 Ozone effects on alveolar macrophage-stimulated neutrophil and monocyte migration after in vitro exposure (rabbit), 3 I2 induced changes in lung function and plasma eicosanoid levels, effectsof indomethacin and cromolyn sodium (guinea pig), 175 toxicity, cellular adaptation in trachea after prolonged exposure, in vitro evidence (rat), 394 P Paw 2-methoxyethanol-induced malformation, relationship to embryotoxicity (mouse), 195 2,3,4,7,8-Pentachlorodibenzofuran toxicity and disposition after iv exposure, analysis (rhesus monkey), 23 1 Peroxidase leukocyte, oxidation of catechol: o-benzoquinone and o-benzosemiquinone reactions (human), 62 Peroxidation lipids, relationship to intracellular vitamin E and chemical toxicity (rat hepatocytes), 288 Peroxisomes hepatic, proliferation, induction by lactofen (mouse), 72 Pharmacokinetics tetrachloroethylene, physiological model (human, mouse, rat), 108 Pharmacology central nervous system seizure-related endpoints, effects of hexachlorocyclohexane isomers (mouse), 146 Phencyclidine ‘H-labeled, and metabolites, whole-body autoradiographic localization (mouse), 42 1 Phenobarbital effect of pretreatment on carbon tetrachloride in vivo metabolism (rat), 247

SUBJECT INDEX l-( 1-Phenylcyclohexyl)-4-hydroxypiperidine distribution after [3H]phencyclidine administration, analysis by whole-body autoradiography (mouse), 421 4-Phenylpiperidionocyclohexanol distribution after [‘Hlphencyclidine administration, analysis by whole-body autoradiography (mouse), 421 Piperazine low-level inhalation exposure, subsequent N-mononitrosopiperazine excretion, effects of dietary nitrate and ascorbate (human), 28 1 Plasma eicosanoid levels, ozone-induced changes, effectsof indomethacin and cromolyn sodium (guinea pig), 175 Platelets role in pulmonary pyrrolizidine poisoning (rat), 463 Prostacyclin plasma levels, ozone-induced changes, effects of indomethacin and cromolyn sodium (guinea pig), 175 Prostaglandin E, plasma levels, ozone-induced changes, effects of indomethacin and cromolyn sodium (guinea pig), 175 Proteins cadmium-binding, testicular, role in strain dependence ofresistance and susceptibility to cadmium testicular toxicity (mouse), 47 hepatic, interaction with methylene chloride after inhalation exposure (mouse, rat), 1 5-(2-Pyrazinyl)-4-methyl-1,2dithiol-3-thione, see OltiPraz Pyridostigmine effect on muscarinic receptor binding number in pheochromocytoma PC 12 cells (rat), 257 Pyrocatechol oxidation by horseradish peroxidase and human leukocyte peroxidase: o-benzoquinone and c-benzosemiquinone reactions, 62 Pyrrolizidine pulmonary poisoning, role of platelets (rat), 463 R Resistance to cadmium testicular toxicity, strain dependence: role of testicular cadmium-binding proteins (mouse), 47 to ozone toxicity by cellular adapatation in trachea, in vitro evidence (rat), 394 Respiration hepatic mitochondrial, acetaminophen-induced inhibition (mouse), 378 Respiratory tract acetaminophen-induced toxicity, protective effects of dimethyl sulfoxide (mouse), 452

521

metabolism of inhaled materials, effects on disposition, 484 xenobiotic activation and detoxication sites: implications for chemically induced toxicity, 493 S

effect on muscarinic receptor binding number in pheochromocytoma PC12 cells (rat), 257 Serotonin role in N-methylthiobenzamide-induced pneumotoxicity (rat), I65 Soman effect on muscarinic receptor binding number in pheochromocytoma PC 12 cells (rat), 257 Species differences autoxidative tissue damage induction by iron nitrilotriacetate (mouse, rat), 89 biliary excretion of glutathione-related thiols and methylmercury (guinea pig, hamster, mouse, rabbit, rat), 35 1 macromolecular interactions of methylene chloride in liver and lung after inhalation exposure (mouse, rat), I tetrachloroethylene pharmacokinetics, physiological model (human, mouse, rat), 108 Spermatocytes epididymal, hydralazine effects on growth, differentiation, and chromatin structure (mouse), 339 Spleen lymphocyte function, suppression by 7,12-dimethylbenz[a]anthracene in vitro (mouse), 369 Steroids nitrogen-containing, hepatotoxicity, role of cytochrome P-450 in detoxication (rat), 403 Strain differences resistance and susceptibility to cadmium testicular toxicity: role of testicular cadmium-binding proteins (mouse), 47 Streptozocin induced diabetes, long-term, effectson bromobenzene and carbon tetrachloride toxicity and biotransformation (rat liver), 329 Streptozotocin, see Streptozocin Superoxide radicals generation by polymorphonuclear leukocytes, stimulation by chlordane (guinea pig), 137 T

2,4,5-T structural analogs, activation of hepatic glutathione 9 transferases, characterization (rat), 275 Tabun effect on muscarinic receptor binding number in pheochromocytoma PC12 cells (rat), 257

522

SUBJECT INDEX

Teratogenicity Z-methoxyethanol, relationship to disposition (mouse). 195 Testis cadmium toxicity, associated resistance and susceptibility, strain dependence: role of testicular cadmium-binding proteins (mouse), 47 germ cells, hydralazine effects on growth, differentiation, and chromatin structure (mouse), 339 Tetrachloroethylene pharmacokinetics, physiological model (human, mouse, rat), 108 Thromboxane A2 plasma levels, ozone-induced changes, effects of indomethacin and cromolyn sodium (guinea pig), 175 Tissues mercury content after unilateral nephrectomy, analysis (rat), 187 Trachea epithelium, cellular adaptation to ozone toxicity after prolonged exposure, in vitro evidence (rat), 394 xenobiotic activation and detoxication: implications for chemically induced toxicity (rat), 493

Tumor cells Friend leukemia, hydralazine effects on growth, differentiation, and chromatin structure (mouse), 339 pheochromocytoma PC 12, muscarinic receptor binding number, effects of organophosphates and nerve growth factor (rat), 257 V

Vincristine general toxicity and peripheral nerve alterations after chronic treatment, analysis (rabbit), 433 Vitamin E intracellular levels, relationship to lipid peroxidation and chemical toxicity (rat hepatocytes), 288 vx effect on muscarinic receptor binding number in pheochromocytoma PC 12 cells (rat), 25 7 Y Yeast mitochondrial electron transport, inhibition by high amoxapine concentrations, biochemical evidence, 118