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Subject index—Volume 4, 1972
Subject
Index-Volume
Blastogenic transformation, antigen-stimulalated, measurement by scintillation spectrometry, 143-151 Bone marrow. of mouse, thymus-derived lymphocytes in, 305-315 Bovine serum albumin (BSA), immune response to, thymus-bone marrow cell cooperation in, 134-142
A .2gammaglobulinemic chicks, proliferative and functional capacity of lymphocytes transferred to, 51-65 hlloantigens, H-Z and TL types, isolation from surface of mouse lymphocytes, 187-191 S-2- (3,\minopropylamino) ethylphosphorothoic acid (WR-2721)) radioprotective and toxic effects of, on development of immunocompetent cells, 256-263 Anergy, diseases with, lymphocyte-macrophage interaction in patients with, 228-242 Antibody as regulant of immune response, 66-85 stimulation of production of by spleen cells, immunization related to, 447452 Antibody-forming cell, antigen-stimulated, in Y& migration pathway in rabbit, 197-202 A4ntibody response, DNA replication as prerequisite for induction of, 351-366 Antigen (s) cells binding, in hemocyanin-tolerant rats, 289-303 cross-reactivity of, at level of thymusderived cells, 179-181 processing of, by macrophage cells, theoretical model for (hypothesis), 175-178 178 stimulated antibody-forming cell in rabbit, 197-202 stimulation of blastogenic transformation by, 143-151 thymus-independent, from heterologous red cells, liposaccharide role in, 416424 Antigen-antibody-complement co m p 1 e x e s, lymphocytes capable of binding, electron microscopy of, 279-287 Antilymphocyte serum, chronic administration of, recovery of immunocompetence of lymphoid cells after cessation of, 333340 Appendix, lymphopenia produced by polyethylene-32P strips applied to, 407-415
C Cellular events, in tolerance, induction and loss. 116-142 Chickens agammaglobulinemic, lymphocyte capacity after transfer to, 51-65 delayed-type hypersensitivity in, assay for, 20-28 Corticotropin, as inhibitor of lymphocyte recirculation, 8692 Cortisone, effects on PHA-responding pool of cells in thymus, 93-105 Cytotoxicity, lymphocyte-mediated ; induction by antibody-coated target cells, 1-19 D DNA replication of, as a prerequisite for induction of primary antibody response, 351-366 synthesis in T and B lymphocytes, selective induction of, 381-393 E Erythrocytes,
induction
see Red cells F
Flagellin, enzymatic proteolysis of, induction of enhanced delayed-type hypersensitivity to, 264-278 G Graft
vs. host reactions, lymphocytes initiating, cellular control of, 192-196 H
H-2
alloantigens, isolation from surface of mouse lymphocytes, 187-191 Hapten-carrier responses, effects of “accelerated’ immune response on, 29-38 Hemocyanin-binding cells, in hemocyanintolerant rats, 289-303 Hodgkin’s disease, lymphocyte-macrophage interaction in patients with, 228-242
B B lymphocytes, selective synthesis in, 381-393
4, 1972
of DNA
455
456
SUBJECT
Hypersensitivity (delayed) in chickens, adaptation of migrationinhibition assay, 20-28 induction to flagellin by peptic fragments of hydrolyzed flagellin, 264-278 I Immune response(s) cells involved in, 197-202 cell-mediated enhancement by passive antibody, 6685 lymphocytes active in, 305-315, 316-332, 333-340 thymus and lymphocyte role in, 39-50 by combination of B- and T-cells with peritoneal macrophages in, 341-350 in peroxidase-stimulated rat lymph nodes, 4.25-441 regulation of, 29-38 by antibody, 6&85 Imnzunity, In. Vitro Methods in Cell-Mediated Immunity, by B. R. Bloom and P. R. Glade (book review), 203 Immunization, repeated or prolonged, failure to stimulate antibody production by spleen cells, 447-452 Immunocompetent cells, WR-2721 effects on, 256-263 Immunology, as independent discipline (editorial), 109-115 Immunosuppressant, from group A streptococci, susceptibility of mouse lymphocytes to, 394406 In Vitro Methods ht Cell-Mediated Imnzuxity, by B. R. Bloom and P. R. Glade (book reviezu), 203
INDEX
in culture, mixed reactivity of, related to H-2 histocompatibility loci differences, 442-446 cytotoxity mediated by, induction by antibody-coated target cells, l-19 initiating graft vs. host reactions, cellular control of, 192-196 interaction with macrophage in lymphocyte transformation in Wiskott-Aldrich syndrome, 228-242 isolation of H-2 and TL alloantig-ens from surface of, 187-191 mitogen-stimulated human peripheral blood type, requirement for restimulation of progeny, 243-255 recirculation of, inhibition by stress and corticotropin, 86-92 from sensitized rat lymph nodes, obtained by velocity sedimentation, 152-162 thymus-derived, role in cell-mediated immune response, 39-50 Lymphopenia, from polyethylene-3’P strips applied to rabbit appendix, 407-415 Lymphoid cells, from mouse, functional heterogeneity of, 367-380 Macrophage (s) antigen processing by theoretical model for (hypothesis), 175-178 bactericidal capacity of, enhancement by antigenically immune lymphocytes,
163-174 combination of B- and T-cells with, immune response from, 341-350 interaction with lymphocytes in lymphocyte transformation in Wiskott-Aldrich syndrome, 228-242 kinetic studies on, 207-217
L Liposaccharides, in conversion of red cells to thymus-independent antigens, 416424 Lymphocyte(s), see also B lymphocytes, T lymphocytes antigenically stimulated immune type, enhancement of macrophage bactericidal capacity by, 163-174 bursal, proliferative and functional capacity of after transfer to agammaglobulinemic chicks, 51-65 capable of binding antigen-antibody complement complexes, electron microscopy of, 279-287 in cell-mediated immune responses, 305-
315, 316-332, 333-340
M Mice changes in PHA-responding pool of cells in thymus of, 93-105 isolation of lymphocytes active in cellmediated immune responses in, 305315, 316332, 333-340 lymphocytes of, isolation of H-2 and TL alloantigens from surface of, 187-191 lymphocytes from susceptibility to immunosuppressant from group A streptococci, 394406 normal and immunized rosette-forming cells of, 218-227 lymphocytes stimulated by. continued proliferation of, 243-255
SUBJECT
responsiveness to, acquisition of during ontogeny of thymocytes and T lymphocytes, 367380 Multiple-sample processor, for precipitation of radioactively labeled samples, 182-186
P cells, radiolabeled, effect of specific antisera on, 207-217 Peroxidase, lymph nodes stimulated by, immune response related to cellular differentiation and antibody localization, 425-441 PHA-responding pool of cells, changes in thymus, after cortisone or X-ray treatment, 93-105
Spleen
cells, production of antibody by, immunization effects on, 447-452 Streptococci, immunosuppressant from, different susceptibility of mouse lymphocytes to, 3944-106 Stress, as inhibitor of lymphocyte recirculation, 86-92 T
Peritoneal
R Rabbit lymphopenia produced in, by polyethylene-32P strips applied to appendix, 407-415 migration pathway of antigen-stimulated antibody-forming cell in, 197-202 Radiolabeled, samples, precipitation by semiautomatic multiple-sample processor, 182-186 Rat(s) enriched subpopulations of lymph node lymphocytes from, 152-162 hemocyanin-tolerant, incidence of hemocyanin-binding cells in, 289-303 induction and loss of tolerance in, 116142 lymph nodes of, primary immune response in, relation to cellular differentiation and antibody localization, 425441 Red cells, heterologous, conversion to thymus-independent antigens by lipopolysaccharides, 416-424 Rosette-forming cells, of normal and immunized mice, ultrastructure and radioautography of, 218-227 s Samples,
radioactively labeled, precipitation of, by semi-automatic multiplesample processor, 182-186 Scintillation spectrometry, in measurement of antigen-stimulated blastogenic transformation, 143-151
457
INDEX
Target
cells, antibody-coated, lymphocytemediated cytotoxity induced by, 1-19 T-cells, role in cross-reactivity of antigens, 179-181 Three-cell mosaic culture, 341-350 Thymocytes ontogeny of, acquisition of mitogen responsiveness during, 367-380 cortical and medullary inverse relation between production of, 93-105 immunocompetent subpopulation of, in mice, identification and recovery of, 316-332 Thymus, role in cell-mediated immune response, 39-50 TL alloantigens, isolation from surface of mouse lymphocytes, 187-191 T lymphocytes ontogeny of, acquisition of mitogen responsiveness during, 367-380 selective induction of DNA synthesis in, 381-393 Tolerance, cellular events, in, 116-142 V Velocity
sedimentation, use to obtain enriched subpopulations of rat lymphocytes, 152-162 W
Wiskott-Aldrich syndrome, lymphocytemacrophage interaction in patients with, 228-242 WR-2721, radioprotcctive and toxic effects of immunoof, on development competent cells, 25f%-263 X X-ray,
effects on PHA-responding cells in thymus, 93-105
pool of
Index-Volume
Blastogenic transformation, antigen-stimulalated, measurement by scintillation spectrometry, 143-151 Bone marrow. of mouse, thymus-derived lymphocytes in, 305-315 Bovine serum albumin (BSA), immune response to, thymus-bone marrow cell cooperation in, 134-142
A .2gammaglobulinemic chicks, proliferative and functional capacity of lymphocytes transferred to, 51-65 hlloantigens, H-Z and TL types, isolation from surface of mouse lymphocytes, 187-191 S-2- (3,\minopropylamino) ethylphosphorothoic acid (WR-2721)) radioprotective and toxic effects of, on development of immunocompetent cells, 256-263 Anergy, diseases with, lymphocyte-macrophage interaction in patients with, 228-242 Antibody as regulant of immune response, 66-85 stimulation of production of by spleen cells, immunization related to, 447452 Antibody-forming cell, antigen-stimulated, in Y& migration pathway in rabbit, 197-202 A4ntibody response, DNA replication as prerequisite for induction of, 351-366 Antigen (s) cells binding, in hemocyanin-tolerant rats, 289-303 cross-reactivity of, at level of thymusderived cells, 179-181 processing of, by macrophage cells, theoretical model for (hypothesis), 175-178 178 stimulated antibody-forming cell in rabbit, 197-202 stimulation of blastogenic transformation by, 143-151 thymus-independent, from heterologous red cells, liposaccharide role in, 416424 Antigen-antibody-complement co m p 1 e x e s, lymphocytes capable of binding, electron microscopy of, 279-287 Antilymphocyte serum, chronic administration of, recovery of immunocompetence of lymphoid cells after cessation of, 333340 Appendix, lymphopenia produced by polyethylene-32P strips applied to, 407-415
C Cellular events, in tolerance, induction and loss. 116-142 Chickens agammaglobulinemic, lymphocyte capacity after transfer to, 51-65 delayed-type hypersensitivity in, assay for, 20-28 Corticotropin, as inhibitor of lymphocyte recirculation, 8692 Cortisone, effects on PHA-responding pool of cells in thymus, 93-105 Cytotoxicity, lymphocyte-mediated ; induction by antibody-coated target cells, 1-19 D DNA replication of, as a prerequisite for induction of primary antibody response, 351-366 synthesis in T and B lymphocytes, selective induction of, 381-393 E Erythrocytes,
induction
see Red cells F
Flagellin, enzymatic proteolysis of, induction of enhanced delayed-type hypersensitivity to, 264-278 G Graft
vs. host reactions, lymphocytes initiating, cellular control of, 192-196 H
H-2
alloantigens, isolation from surface of mouse lymphocytes, 187-191 Hapten-carrier responses, effects of “accelerated’ immune response on, 29-38 Hemocyanin-binding cells, in hemocyanintolerant rats, 289-303 Hodgkin’s disease, lymphocyte-macrophage interaction in patients with, 228-242
B B lymphocytes, selective synthesis in, 381-393
4, 1972
of DNA
455
456
SUBJECT
Hypersensitivity (delayed) in chickens, adaptation of migrationinhibition assay, 20-28 induction to flagellin by peptic fragments of hydrolyzed flagellin, 264-278 I Immune response(s) cells involved in, 197-202 cell-mediated enhancement by passive antibody, 6685 lymphocytes active in, 305-315, 316-332, 333-340 thymus and lymphocyte role in, 39-50 by combination of B- and T-cells with peritoneal macrophages in, 341-350 in peroxidase-stimulated rat lymph nodes, 4.25-441 regulation of, 29-38 by antibody, 6&85 Imnzunity, In. Vitro Methods in Cell-Mediated Immunity, by B. R. Bloom and P. R. Glade (book review), 203 Immunization, repeated or prolonged, failure to stimulate antibody production by spleen cells, 447-452 Immunocompetent cells, WR-2721 effects on, 256-263 Immunology, as independent discipline (editorial), 109-115 Immunosuppressant, from group A streptococci, susceptibility of mouse lymphocytes to, 394406 In Vitro Methods ht Cell-Mediated Imnzuxity, by B. R. Bloom and P. R. Glade (book reviezu), 203
INDEX
in culture, mixed reactivity of, related to H-2 histocompatibility loci differences, 442-446 cytotoxity mediated by, induction by antibody-coated target cells, l-19 initiating graft vs. host reactions, cellular control of, 192-196 interaction with macrophage in lymphocyte transformation in Wiskott-Aldrich syndrome, 228-242 isolation of H-2 and TL alloantig-ens from surface of, 187-191 mitogen-stimulated human peripheral blood type, requirement for restimulation of progeny, 243-255 recirculation of, inhibition by stress and corticotropin, 86-92 from sensitized rat lymph nodes, obtained by velocity sedimentation, 152-162 thymus-derived, role in cell-mediated immune response, 39-50 Lymphopenia, from polyethylene-3’P strips applied to rabbit appendix, 407-415 Lymphoid cells, from mouse, functional heterogeneity of, 367-380 Macrophage (s) antigen processing by theoretical model for (hypothesis), 175-178 bactericidal capacity of, enhancement by antigenically immune lymphocytes,
163-174 combination of B- and T-cells with, immune response from, 341-350 interaction with lymphocytes in lymphocyte transformation in Wiskott-Aldrich syndrome, 228-242 kinetic studies on, 207-217
L Liposaccharides, in conversion of red cells to thymus-independent antigens, 416424 Lymphocyte(s), see also B lymphocytes, T lymphocytes antigenically stimulated immune type, enhancement of macrophage bactericidal capacity by, 163-174 bursal, proliferative and functional capacity of after transfer to agammaglobulinemic chicks, 51-65 capable of binding antigen-antibody complement complexes, electron microscopy of, 279-287 in cell-mediated immune responses, 305-
315, 316-332, 333-340
M Mice changes in PHA-responding pool of cells in thymus of, 93-105 isolation of lymphocytes active in cellmediated immune responses in, 305315, 316332, 333-340 lymphocytes of, isolation of H-2 and TL alloantigens from surface of, 187-191 lymphocytes from susceptibility to immunosuppressant from group A streptococci, 394406 normal and immunized rosette-forming cells of, 218-227 lymphocytes stimulated by. continued proliferation of, 243-255
SUBJECT
responsiveness to, acquisition of during ontogeny of thymocytes and T lymphocytes, 367380 Multiple-sample processor, for precipitation of radioactively labeled samples, 182-186
P cells, radiolabeled, effect of specific antisera on, 207-217 Peroxidase, lymph nodes stimulated by, immune response related to cellular differentiation and antibody localization, 425-441 PHA-responding pool of cells, changes in thymus, after cortisone or X-ray treatment, 93-105
Spleen
cells, production of antibody by, immunization effects on, 447-452 Streptococci, immunosuppressant from, different susceptibility of mouse lymphocytes to, 3944-106 Stress, as inhibitor of lymphocyte recirculation, 86-92 T
Peritoneal
R Rabbit lymphopenia produced in, by polyethylene-32P strips applied to appendix, 407-415 migration pathway of antigen-stimulated antibody-forming cell in, 197-202 Radiolabeled, samples, precipitation by semiautomatic multiple-sample processor, 182-186 Rat(s) enriched subpopulations of lymph node lymphocytes from, 152-162 hemocyanin-tolerant, incidence of hemocyanin-binding cells in, 289-303 induction and loss of tolerance in, 116142 lymph nodes of, primary immune response in, relation to cellular differentiation and antibody localization, 425441 Red cells, heterologous, conversion to thymus-independent antigens by lipopolysaccharides, 416-424 Rosette-forming cells, of normal and immunized mice, ultrastructure and radioautography of, 218-227 s Samples,
radioactively labeled, precipitation of, by semi-automatic multiplesample processor, 182-186 Scintillation spectrometry, in measurement of antigen-stimulated blastogenic transformation, 143-151
457
INDEX
Target
cells, antibody-coated, lymphocytemediated cytotoxity induced by, 1-19 T-cells, role in cross-reactivity of antigens, 179-181 Three-cell mosaic culture, 341-350 Thymocytes ontogeny of, acquisition of mitogen responsiveness during, 367-380 cortical and medullary inverse relation between production of, 93-105 immunocompetent subpopulation of, in mice, identification and recovery of, 316-332 Thymus, role in cell-mediated immune response, 39-50 TL alloantigens, isolation from surface of mouse lymphocytes, 187-191 T lymphocytes ontogeny of, acquisition of mitogen responsiveness during, 367-380 selective induction of DNA synthesis in, 381-393 Tolerance, cellular events, in, 116-142 V Velocity
sedimentation, use to obtain enriched subpopulations of rat lymphocytes, 152-162 W
Wiskott-Aldrich syndrome, lymphocytemacrophage interaction in patients with, 228-242 WR-2721, radioprotcctive and toxic effects of immunoof, on development competent cells, 25f%-263 X X-ray,
effects on PHA-responding cells in thymus, 93-105
pool of