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SUN-PP224: The Influence of Short-Term Low Carbohydratehigh Fat Diet on Survival After Gut Ischemia Reperfusion in Mice
S106 gathered. The nutritional status was determined using WHO criteria and the food intake and daily requirements were calculated using D-A-CH references and dietetic software Prodi Expert 5.6. Results: Analysis of data shows that in last 5 years under nutrition among hospitalized children has significantly decreased (30%, from 12% to 8%). Also, data analysis showed that the number of patients who did not meet at least 60% of their estimated daily requirements (EDR) decreased in last two years, in comparison to first three, for at least 15%, from 35% to about 26 30% of hospitalized children. Conclusion: Continuous education and awareness incensement resulted in significant changes in malnutrition prevalence in hospitalized children. Hospital staff and others involved in patient care and treatment become more aware and cooperative regarding the importance of adequate nutrition therapy of hospitalized pediatric patients. Disclosure of Interest: None declared
SUN-PP223 REDUCED LEAN BODY MASS WITHIN SCHOOL CHILDREN WITH NORMAL BMI IS ASSOCIATED WITH LOW GROSS MOTOR PERFORMANCE T. van Kernebeek1 , A.W. de Schipper1 , M.F. Engberink2 , H. Toussaint1 , P.J. Weijs1,3 . 1 School of Sports and Nutrition, 2 Nutrition and Dietetics, Amsterdam University of Applied Sciences, 3 Nutrition and Dietetics, VU University Medical Center, Amsterdam, Netherlands Rationale: For health management schoolchildren’s BMI is leading. Normal BMI children (based on Cole criteria) are generally considered as healthy. Considering the epidemic of overweight in concurrence with sedentary behaviour in children, low lean mass may be a limiting factor for gross motor performance. Methods: In a pilot study (n = 366) we measured lean mass of 6 12 y old children with bioelectrical impedance analysis (Tanita BC418). According to the Cole criteria children were underweight (n = 23), normal weight (n = 305), and overweight (n = 38). Gross motor level was assessed with the Motor Scan, consisting of 4 test items (jumping-force, jumpingcoordination, one-leg balance and ball skills) by calculating ‘motor lead’ in days (motor age minus current age). For normal weight group (n = 305), lean mass (kg) was natural log transformed, adjusted for age and height for boys and girls separately, and standard deviation score (sds) calculated (“lean index”). Gross motor level is presented as mean (SD) per lean index group (A < 2; B 2 upto 1; C 1 upto +1; D +1 upto +2; E >+2 sds). Logistic regression analysis relates low lean index (< 1 sds) and delayed motor development (>1 y delay). Results: Normal weight children had a mean motor lead of 45 days (SD 465). The lean index groups showed lower gross motor performance for lower lean index [A 610 (n = 1); B 163 (515); C 38 (451); D +24 (450); E +273 (494)]. Odds ratio for delayed motor development for normal weight children with a low lean index (n = 45) was 2.48 (95% CI 1.28, 4.82; p = 0.007). Conclusion: The generally held view that normal weight schoolchildren can be considered healthy, should be viewed with caution since the gross motor performance of the child
Poster presentations seems to relate in part to the age, sex, and height adjusted lean mass development of the child. Disclosure of Interest: None declared
SUN-PP224 THE INFLUENCE OF SHORT-TERM LOW CARBOHYDRATEHIGH FAT DIET ON SURVIVAL AFTER GUT ISCHEMIA REPERFUSION IN MICE T. Watanabe1,2 , K. Fukatsu2 , S. Murakoshi2 , J. Yamamoto1 , K. Hase1 , H. Yasuhara2 . 1 Surgery, National Defense Medical College, Tokorozawa city, 2 Surgical Center, The University of Tokyo Hospital, Tokyo, Japan Rationale: Low carbohydrate-high fat diets (LCHFDs) reportedly reduce body weight and cardiovascular disease risk and also improve glucose tolerance in obese people. LCHFDs are also expected to prevent weight gain in non-obese people. Therefore, numbers of critically ill or severely injured patients who have consumed LCHFDs prior to hospital admission might well be anticipated to increase in the near future. However, the influence of LCHFDs on host response to surgical insults remains unclear. Herein, we examined whether short-term LCHFD intake affects survival after gut ischemia reperfusion (I/R) in mice. Methods: Six-week-old male ICR mice (n = 22) were randomized to a normal carbohydrate-normal fat diet group (NF; TPN solution consisting of 20% calories from fat, 15% from amino acids, 65% from carbohydrate) (n = 9) or an isocaloric and isonitrogenous LCHFD group (TPN solution consisting of 60% calories from fat, 15% from amino acids, 25% from carbohydrate) (n = 13) and underwent gastrostomy. Mice were fed the respective diets via gastrostomy for five days. Then, the superior mesenteric artery was occluded for 60 minutes by microvascular clipping, and survival was observed for 48 hours after reperfusion. Results: There were no significant differences in preexperimental body weight or body weight change after dietary manipulation between the two groups. Survival rates of the NF and LCHFD groups after reperfusion were 44.4% vs 38.5% at 8 hours, 44.4% vs 38.5% at 24 hours, and 22.2% vs 23.1% at 48 hours, respectively. There were no significant differences in survival time (log rank test; p = 0.64). Conclusion: Short-term LCHFD feeding did not affect survival after gut I/R in mice. Clinicians apparently do not have to take special care of surgical patients who have consumed LCHFDs. However, we do need to investigate the influences of longer term LCHFDs on outcomes after surgical insults of various degrees. Disclosure of Interest: None declared
SUN-PP223 REDUCED LEAN BODY MASS WITHIN SCHOOL CHILDREN WITH NORMAL BMI IS ASSOCIATED WITH LOW GROSS MOTOR PERFORMANCE T. van Kernebeek1 , A.W. de Schipper1 , M.F. Engberink2 , H. Toussaint1 , P.J. Weijs1,3 . 1 School of Sports and Nutrition, 2 Nutrition and Dietetics, Amsterdam University of Applied Sciences, 3 Nutrition and Dietetics, VU University Medical Center, Amsterdam, Netherlands Rationale: For health management schoolchildren’s BMI is leading. Normal BMI children (based on Cole criteria) are generally considered as healthy. Considering the epidemic of overweight in concurrence with sedentary behaviour in children, low lean mass may be a limiting factor for gross motor performance. Methods: In a pilot study (n = 366) we measured lean mass of 6 12 y old children with bioelectrical impedance analysis (Tanita BC418). According to the Cole criteria children were underweight (n = 23), normal weight (n = 305), and overweight (n = 38). Gross motor level was assessed with the Motor Scan, consisting of 4 test items (jumping-force, jumpingcoordination, one-leg balance and ball skills) by calculating ‘motor lead’ in days (motor age minus current age). For normal weight group (n = 305), lean mass (kg) was natural log transformed, adjusted for age and height for boys and girls separately, and standard deviation score (sds) calculated (“lean index”). Gross motor level is presented as mean (SD) per lean index group (A < 2; B 2 upto 1; C 1 upto +1; D +1 upto +2; E >+2 sds). Logistic regression analysis relates low lean index (< 1 sds) and delayed motor development (>1 y delay). Results: Normal weight children had a mean motor lead of 45 days (SD 465). The lean index groups showed lower gross motor performance for lower lean index [A 610 (n = 1); B 163 (515); C 38 (451); D +24 (450); E +273 (494)]. Odds ratio for delayed motor development for normal weight children with a low lean index (n = 45) was 2.48 (95% CI 1.28, 4.82; p = 0.007). Conclusion: The generally held view that normal weight schoolchildren can be considered healthy, should be viewed with caution since the gross motor performance of the child
Poster presentations seems to relate in part to the age, sex, and height adjusted lean mass development of the child. Disclosure of Interest: None declared
SUN-PP224 THE INFLUENCE OF SHORT-TERM LOW CARBOHYDRATEHIGH FAT DIET ON SURVIVAL AFTER GUT ISCHEMIA REPERFUSION IN MICE T. Watanabe1,2 , K. Fukatsu2 , S. Murakoshi2 , J. Yamamoto1 , K. Hase1 , H. Yasuhara2 . 1 Surgery, National Defense Medical College, Tokorozawa city, 2 Surgical Center, The University of Tokyo Hospital, Tokyo, Japan Rationale: Low carbohydrate-high fat diets (LCHFDs) reportedly reduce body weight and cardiovascular disease risk and also improve glucose tolerance in obese people. LCHFDs are also expected to prevent weight gain in non-obese people. Therefore, numbers of critically ill or severely injured patients who have consumed LCHFDs prior to hospital admission might well be anticipated to increase in the near future. However, the influence of LCHFDs on host response to surgical insults remains unclear. Herein, we examined whether short-term LCHFD intake affects survival after gut ischemia reperfusion (I/R) in mice. Methods: Six-week-old male ICR mice (n = 22) were randomized to a normal carbohydrate-normal fat diet group (NF; TPN solution consisting of 20% calories from fat, 15% from amino acids, 65% from carbohydrate) (n = 9) or an isocaloric and isonitrogenous LCHFD group (TPN solution consisting of 60% calories from fat, 15% from amino acids, 25% from carbohydrate) (n = 13) and underwent gastrostomy. Mice were fed the respective diets via gastrostomy for five days. Then, the superior mesenteric artery was occluded for 60 minutes by microvascular clipping, and survival was observed for 48 hours after reperfusion. Results: There were no significant differences in preexperimental body weight or body weight change after dietary manipulation between the two groups. Survival rates of the NF and LCHFD groups after reperfusion were 44.4% vs 38.5% at 8 hours, 44.4% vs 38.5% at 24 hours, and 22.2% vs 23.1% at 48 hours, respectively. There were no significant differences in survival time (log rank test; p = 0.64). Conclusion: Short-term LCHFD feeding did not affect survival after gut I/R in mice. Clinicians apparently do not have to take special care of surgical patients who have consumed LCHFDs. However, we do need to investigate the influences of longer term LCHFDs on outcomes after surgical insults of various degrees. Disclosure of Interest: None declared