The 36th Pittsburgh Conference

The 36th Pittsburgh Conference

IX trends m analytical chemistry, vol 4, no 7, 1985 I . 4 Document SPAICEH 502, Report on First Meetmg of Scientific Steering Commtttee on TOXK 011...

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IX

trends m analytical chemistry, vol 4, no 7, 1985

I

. 4 Document SPAICEH 502, Report on First Meetmg of Scientific Steering Commtttee on TOXK 011 Syndrome, WHO, Madrrd, 20-22 June, 1984 5 P GranJean and S Tarkowskl, WHO Copenhagen 1984, Report on WHO meetmg of Workmg Group on Denatured Rapeseed Otl Toxtcology Syndrome, Madnd, March 21-25,1983

6 B B Wheals, M J Whltehouse and C J Curry, J Chromatogr , 238 (1982) 203

7 M V Dabno, J Htgh Resol Chromatogr Chem

Comm ,5 (1982) 578

8 Toxic Epldemlc Syndrome Study Group, TOXK Epldemlc Syndrome 9 10

Spam, 1981 Lancet, 2 (1982) 697 A Pestaiia and E Muiioz, Nature (London), 298 (1982) 608 N de Vera, R M Cnstofol, L

Cam6n, A Planas and E Rodriguez FarrC, m A Pestaiia (Editor), Collected papers for programme for study of Sparush Toxrc Od Syndrome, C S I C , Madrid, 1983, Vol 2, p

201 11 3 Rodngo, M Robles, I Mayo, A Pestaiia, A Marquet, V Larraga and E Mufioz, Lancet, 1 (1983) 414 12 S Moncada, R J Flower and J R Vane, Prostaglandms, prostacyclm and thromboxane A The Pharmacologrcal Bass of Therapeutics, Mac-

Mlllan Pubhshmg Co , 1980, pp 660 13 E Gelpi, R Frelxa, J Rosellb, M Rlgaud and J C Breton, presented at the Nineteenth International Symponurn on Advances m Chromatography, Amsterdam, 3-6 October 1983

14 M Garcia Gil, M W van Lookeran, S Alemany, A M Mumclo and J M Mato, FEBS Letters, 162 (1983) 151 15 R Frelxa, J Casas, 0 Bulbena, J Gaya, R Gmtart, J Roselld and E Gelpi, II Congreso Luso-Espariol de Broquimlca, 26-30,1983

Barcelona,

September

16 H Rabmovltch, J Durand, M RIgaud, F Mendy and J C Breton, Llplds, 16 (1981) 518

17 M Garcia Gil, J Traver, C Suarez, D Mann Cao and J M Mato, Bzothem

Pharmacol ,33 (1984) 3303

18 J Ablan, I Ramn, 0 Bulbena, J Rosell6, E Rodriguez FarrC and E Gelpi, m preparation 19 G C Aldergler, N Gualde, S Mexmain, H Rabmovltch, H Retemaud and M Rigaud, Prostaglandms, Leukotrzenes and Meduwze, 13 (1984) 99 Em&o Gelpi IS at the Analytical Neurochemistry Unit, Instttuto de Quimlca BloOrgBnlca, C S I C , Jorge Gwona Salgado 18-26, Barcelona 08034, Spatn

meeting reports The 36th Pittsburgh Conference

A report on the 36th Pittsburgh Conference on Analyttcal Chemistry and Applted Spectroscopy, held In New Orleans, LA, USA, 25 February-l March, 1985 Because of space shortage m Atlantic City’s convention hall the Plttsburgh Conference moved to New Orleans, LA, U S A Durmg the Pittsburgh Conference Committee press conference this year’s presldent Allen J Sharkms mentioned that 1830 standard booth areas (10 x 10 ft) were avallable for the exhlbltlon For the 1984 exhlbltlon m Atlantic City, there were 1607 There were 730 exhlbltmg compames and organizations this year and m Atlan0165-9936/85/$02

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tic City m 1984 about 600 In 1984 there were 961 papers presented and this year 1231 This growth m both the number of exlubltors and the number of papers presented resulted m the New Orleans Convention Centre already being too small After these statlstlcal announcements vice president Richard Danshlk, president of next year’s Conference announced that the 1986 Plttsburgh Conference will agam be held m Atlantic City Atlantic City’s Convention Centre has now been renovated and extended, costmg $18 000 000, and the number of hotel rooms has mcreased by 600 by the opening of new hotels The Committee has also always received excellent cooperation by the

authorltles of Atlantic City and the hotel managements m that town Site selectlon president John Quelser said that if the growth of the Conference both m the number of exhibitors and m the number of papers presented 1s contmumg m the years to come, an exhlbltlon area of 500 000 sq ft will be required by 1990 For the 1987 Pittsburgh Conference the site selectlon commlttee hesitates between the convention centres of New York, Chlcago and agam Atlantic City For 1988 the committee 1s consldermg the scheduled extended convention centre of New Orleans, Atlanta, New York or Atlantic City For 1989 the convention centre of Atlanta 1sbeing consldered which will by then be fully completed In 1980, the number of conferees was about 14000, by 1984 this number had mcreased to 24648 In New Orleans there were 20733 attendees including 7831 exhlbltors With this number, the pesslmlsts of last year’s press conference were right New Orleans, warm and rainy on the time of the Conference, lies too far from the major centres of the Amencan chemical industry However, the exhibitors were unammous m their concluslons that the number of serious leads m New Orleans was greater The Pittsburgh Conference Commlttee 1s agam consldermg extendmg the conference period from 4% to 5 days As the exhlbltlon grows It 1s more difficult to get an overvlew of the exhlbltlon and attend a number of papers m the four days period During the evemngs m New Orleans cocktall parties were orgamzed by the major instrument manufacturers The Philips press conference and cocktail party was held aboard the Natchez, a classically bmlt Mlsslsslppl steamer Perkm-Elmer mvlted the press and a number of important customers for a lunch m the Hllton hotel, where president Horace McDonnell talked about the development of the ongmally optlcal company through mechamzatlon, mstrumentatlon and computerlzatlon to the era of robotics The ploneermg work of Zymark m this field has triggered Perkm-Elmer’s developpmg department On the exhlbitlon floor Perkm0

Elsevler

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Elmer’s own robot was indefatigably busy mjectmg samples m the Model from 8300 gas chromatograph Beaconsfield, UK, and m the new Plasma II ICP spectrometer Johnson-scale also showed a robot busy around a Preclsa analytical balance from Switzerland Mettler and Hewlett-Packard showed Zymate robots in action In general, opinions on robotics were rather divided Some fmd the robots as operating mjectlon and diluting instruments very efflclent, whereas others thought already of completely robotlzed analytical laboratories with circular tables on which centrally placed robots are doing all the laboratory work Practically all instrument manufacturers are interested m robotlzatlon However, m the field of sample preparation a lot of fundamental work has to be done The data handlmg and presentation side 1s well developed with only further refmements required Awards The Spectroscopic Society of Plttsburgh presented an award to Professor Peter Grlfflths for his work on gas chromatography (GC)-Fourier transform infrared (FTIR) spectroscopy and high-performance liquid chromatography (HPLC)-FTIR mterfaces The award from the Society of Analytical Chemistry of Plttsburgh was presented to Professor Bruce Kowalskl for his work m the field of chemometrlcs Professor Paul Lauterbur received the Maurice Hasler Award for his work m the field of ‘whole-body’ scanning nuclear magnetic resonance spectrometry The Wllhams-Wright Award was presented to Clara D Craver, president of an independent laboratory for Industrial service m St -Louis, MI, U S A She has done a lot of work on mdustrlal applications of spectroscopic methods of analysis The second scientist receiving the Wdhams-Wright Award was Richard A Nyqulst Nyqulst received his award for his work on the practical apphcatlon of infrared and Raman spectroscopy The Rellley Award for research contrlbutlons m electrochemical analysis was given to Professor Ralph N Adams for his work 0165-9936/85/$02

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on m vzvo applications chemical analysis

of electro-

Computers and data systems The use of microcomputers m combmatlon with analytical eqmpment 1s still growing, but the hardware 1s rapidly growing more onesided In 1984 we saw Dlgltal Equlpment’s Rambow and PC-350, Commodore’s 64 and others, Apple’s IIE, Victor, Hewlett-Packard’s 80-series and the IBM-PC This year everythmg looked more simple The affmlty of ‘big blue’ has led to the situation that most manufacturers now offer systems based on a computer from IBM’s PC-family The versions with the colour monitor suffer from a lack of resolution and are somewhat tiring for the eyes of the user The XT-version with the monochromatic high resolution monitor, used for instance as Lab-Net computer by SpectraPhysics, does not have the colour graphics but 1s much better for the user’s eye After IBM’s PC models the Hewlett-Packard Series 100 and 200 microcomputers take the second place m the OEM market The Hewlett-Packard 80 series 1s gradually disappearing from the field of data handling although they are still very useful in controlling processes In the field of the larger data systems for laboratory data management, planning and mvolcmg, the market 1s shared by Digital Equlpment, Perkm-Elmer and HewlettPackard Perkm-Elmer offers vanatlons on the 3200 formula complete, fast, but also very central If the central processor 1s down, the whole system falls Hewlett-Packard and Dlgltal Equipment (Vanan) offer systems with ‘shared responslblhtles A sub system close to the analysis equipment 1s responsible for usable data handling The central part gives a fmlshmg touch to the produced data and cares for planning and mvolcmg The central processmg unit, m the Hewlett-Packard case an HP1000 and m the Varlan solution a Digital Equipment VAX 11/750, 1s stdl able to work when one of the satellites 1s temporarily down Digital Equipment and Varlan offer at this moment a very flexlbel data system In the Digital Equipment booth such

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a system was operational Thk hooked-up equipment varied from a simple Waters Assoc HPLC system to an FTIR system from Nlcolet Agam Perkm-Elmer was the greatest exhibitor with 32 standard booth surfaces of 10 x 10 ft The Leco Corporation followed with 25 standard booths Hewlett-Packard, IBM Instruments, Beckman, Nlcolet , ARL, Fisher Sclentlflc, and Shlmadzu used a booth space of 20 standard surfaces Infrared spectrometry In the field of infrared spectrometry the presence of the impressive FTIR systems was dominating Perkm-Elmer showed the new Model 1700 designed and produced m Beaconsfield, U K , as well as the Model 1800, introduced last year and now agam displayed with the transparent cover The Model 1700 has nearly the same size as the classical dispersive instruments from the U K Blo-Rad’s Dlgllab dlvlslon exposed the FTS 15/80 with the 3200 data system, the FTS 50, the FTS 60 and the top model FTS 80 Dlgllab also introduced FTIR software for use on an Apple Macintosh personal computer Bomem from Canada showed an instrument suitable for spectroscopic research m a range from the far infrared to the far ultraviolet This instrument 1s capable of performing five experiments simultaneously IBM Instruments showed the (Bruker made) IR/38, the IR/32 and the IR/98, coupled with a gas chromatograph Software for FTIR apphcatlons 1s available on the data system 9000 Nlcolet showed the lmproved versions of the 5DX and the 20DX The improved 20DX, the 20DXB, was connected with a Hewlett-Packard HP 5890 gas chromatograph The top model 60SX was coupled with the same mstrument The improvements have given this B-version instruments a better slgnal-tonoise ratio Accuspec showed a number of GC-IR and LC-IR interfaces and a very small gas chromatograph, for using with the interferometers Beckman had improved the FT-IR software and offered the so-called Analect vector based software showed the microsystems Micro/20 0 Elsewer Science Pubhshers B V

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trends m analytlcal chemrstry, vol 4, no 7,198s

and Micro/25 FTIR, the AQS-20, an ‘open-geometry’ FTIR system, sultable for single and double beam operation, the FT 6160 for normal laboratory apphcatlons, the 80 FTIR for process apphcatlons, and the Envlronmental 60, meant for envlronmental research Mattson, a spin-off from Nlcolet, exposed a micro FTIR system, the Cygnus 100 coupled with a Perkm-Elmer Sigma 2000 gas chromatograph, the Starlab datasystem, and a Gygnus 25 coupled with the Hewlett-Packard HP 5890 gas chromatograph Classical dispersive instruments were shown by several exhibitors One of the most recently introduced was Pye Umcam’s PU 9510, dlsplayed m the Sargent-Welch booth Pacific Sclentlflc’s Neotec dlvlslon showed the Models 6250 and 7000 near infrared reflectance spectrometers Dickey-John showed very apphcatlon oriented instruments and Techmcon introduced a special version of the InfraAlyzer 300 for use m the textile industry, the InfraAlyzer 300 TX UV-Vis spectrophotometry In the field of UV-Vls spectrophotometry Perkm-Elmer mtroduced the Lambda 4 family, conslstmg of the Model 4A, 4B, and 4C The A- and B-versions are equipped with an interface for program modules, more or less followmg the example of the Beckman DU-50 series The 4C-version 1s deslgned for cooperation with the laboratory computers of the Perkm-Elmer 7000 series The Beckman DU-50 series was also new The new Novaspec by LKB from Sweden, which IS not bigger than a portable audio cassette recorder 1smeant for pure routme Jobs The Novaspec 1s equipped with automatic wavelength cahbratlon and with an automatic zero adjustment Sargent-Welch showed the Pye Umcams PU 8600 and PU 8800, both rather new on the American market Gllford showed their classically deslgned Model 260 and the advanced Model Response Kontron’s Model 860 seemed mterestmg for the US customer The Bausch & Lomb twins 501 dnd 601 were a complete surprose Both spectrophotometers ale

equipped with modern control panels They fill the gap m the Bausch & Lomb program under the ‘sphtbeam’ 1001 Shlmadzu’s new Model 160 1s designed as a top-of-the-line model m the manufacturer’s hne of routme type instruments The instrument looks like the more expensive Model 260 Varlan showed the DMS-family from Australia, with the top model DMS-70 m combmatlon with the DS15 data system The Varlan top model 2300 was again, after a period of four years, bearing the name of pioneer Howard Cary Inductively coupled plasma and atomic absorption spectrometry In the field of mductlvely coupled plasma (ICP) spectrometry PerkmElmer showed the huge Plasma II spectrometer With this instrument Perkm-Elmer leaves the field of combmatlon instruments for ICP emlsslon and atomic absorption spectrometry With the type mdlcatlon Perkm-Elmer has become somewhat clearer on types and numbers The 4- of even 5-digit type mdlcatlons are obviously out Varlan, m their new SpectrAA-series, also talk about the Models SpectrAAand SpectrAAThese new Varlan mstruments are atomic absorption spectrometers, that, like PerkmElmer’s Plasma II, have to be controlled by an alphanumerlcal keyboard They are meant to be used with computers or dedicated data systems ICP sources without spectrometers were exposed by Labtest Equipment The company showed the Models CPS 40/15 and CPS 40120 Allied Corporation showed the ICAP 9000 from the Jarrell-Ash dlvlslon, a simultaneously operating mstrument, fitted with a self deslgned ICP source Also simultaneously operating 1s the Atomcomp 7000 From the IL-side came the Plasma 200 In the field of atomic absorption Allied showed the Video 22, equipped with the Smith-Hieftje background correction posablhty, the new FASTEC II aerosol desposltlon system, and the furnace atomizer IL 755 Baird showed a mobile spectrometer for atomic emlsslon analysis which 1s still on the productlon floor, the ICP sys-

tem Plasma Spectrovac for analysis and data presentation on more than 60 elements, and the atomic fluorescence system AFS-2000 Buck Scientific showed with then own type mdlcatlon atomic absorption spectrometers from GBS (Australia) The Australian company Itself showed a modernized version of the small atomic absorption spectrometer m the combmatlon booth of the Australian instrument manufacturers Atomic emlsslon and ICP mstruments were also shown m the Instrument SA booth Shown here were the spark spectrometer JobmYvon 32E and the ICP spectrometer 7OP Other types of spectrometry Jasco from Japan again showed the digital polarlmeter DIP-360 and the spectropolarlmeter J-500 Tracer exposed the X-ray fluorescence spectrometer TN6050, ARL showed m the same field the 8680 spectrometer ARL also exhibited the ICP mstruments 3220 and 3210 for sequential analysis, and data systems based on Digital’s PDP-11/23 and IBM’s PC Xertex-Dohrman, also speaallzed m environmental analysis techmques, showed an X-ray fluorescence analyzer Rlgaku displayed the 3071 X-ray spectrometer, X-ray diffraction equipment, and wavelength dispersive X-ray fluorescence spectrometers Prmceton-Gammtech and EG & G/Ortec also showed X-ray fluorescence equipment Charles Evans Associates showed apparatus for the analysis based on X-ray dispersion on surfaces and Dapple Instruments showed tools for the automation of X-ray fluorescence analysis Leeman Labs showed their again somewhat improved ICP spectrometer PT-Analytical, the Amencan Plasmatherm Corporation, showed an automatic atomic absorption spectrometer, equipped with an 8-lamp turret, a 314 m monochromator, and a dual 3%” floppy disk drive for data storage The instrument can also be equipped with a Winchester disk drive Perkm-Elmer Introduced the routme type fluorescence spectrometer Model 650-15 McPherson showed Schoeffel’s scanning fluonmeter Model 750, and Kontron the

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SFM-25 spectrophotofluorlmeter Scmtrex displaced the laser-based fluorlmeter UA-3 The same Canadlan company showed an instrument for flameless atomic absorption analysis, the AAZ-2 Philips introduced the X-ray spectrometers 1404, 1430 and 1606 The 1606 1s a slmultaneously operating instrument, the 1404 and the 1430 are operating sequentially The 1430 1s especially developed for the American market and will not be available for European customers m the short term Phlhps’s EDAX International dlvlslon introduced the improved Model 9100 energy dispersive analysis system Philips also introduced the electron microscope family 515,525, and 535 Cianflone Scientific Instruments Corporation introduced a portable X-ray spectrometer Amray showed their Model 1645 X-ray spectrometer with a large sample chamber and a computer based lme width system Jeol exposed the JSMT-300 scanning electron microscope, Hitachi showed the Model S-530 and S-570 Mass spectrometry

The ICP source for mass spectrometry (MS) was a hot item Sclenx, pioneer m this field, showed two ELAN (elemental analysis) systems VG from the UK exposed the Plasmaquod, an ICP source m combmatlon with a quadrupole mass spectrometer Another technique on the verge of breakthrough 1s the HPLC-MS combmatlon Extranuclear showed the Thermospraymterface for couplmg of HPLC systems to the mass spectrometer In the field of MS itself Nlcolet showed the FTMS2000, developed from the first commercial FTMS system, the FTMS1000 Fmmgan-MAT showed the Model 8400, based on the 8200 concept Extranuclear exposed the ELQ-400 GC-MS system, equipped with Vanan’s 3400 gas chromatograph and a 160 Mb disk unit VG showed the S-version of the well-known 7070, m combmatlon with the HP 5890 gas chromatograph and CVC showed the Superspec 600, based on the time-of-flight prmclple Shlmadzu’s QP-1000 GC-MS system 1s complete with a library system with a capacity of 20 Mb memory

trends m analytical chemstry,

Fmmgan-MAT also showed the TSQ MS-MS-DS system and the THQ thermlomc quadrupole mass spectrometer Nermag from France dlsplayed a combmatlon of the R3010 mass spectrometer with a Delsl gas chromatograph Kratos showed the Series 800 SIMS (digitally controlled secondary ion mass spectrometer), the blo-ion plasma desorptlon source and the MS-25 RFA GC-MS comblnation with a Carlo Erba gas chromatograph Gas chromatography

In the field of gas chromatography Varlan showed the top model m the new 3000-series, the Model 3500, with new or modified detectors and m]ectlon systems The instrument was shown m con]unctlon with the Model 8035 sample mjector IBM Instruments showed a complete lme of gas chromatographs under the type mdlcatlon GC 9630, built m the UK near Cambridge Shlmadzu showed its complete lme of GC instruments, including the modular GC-9AM The GC-8A was equipped with a rigid sample mlectlon system PCP from West-Palmbeach, showed the Femtochem 100, a detection system for gas chromatography based on an ion moblhty spectrometer The wellknown small gas chromatographs from Gow-Mac are now equipped with programming faclhtles and are usable with an flame lomzatlon detector Precision Sampling showed a new sample injector m a horizontal and a vertical mJectlon version Hach displayed Carle apparatus and Sadler introduced retention time mdex software for the Hewlett-Packard Series 80 microcomputers Tracar exhibited the 540 with a photolomzatlon detector and sample concentrator HNU exposed their routme gas chromatograph, the LAB GC-301 Packard and Carlo Erba showed their well-known range of equipment gas chromatographlc Buck Scientific displayed d gds chromatograph of unknown origin with a pleasant large, well finished oven HPLC

In the field of HPLC EM Science, the local representative of E Merck, exhlblted the HPLC products from

vol 4, no 7,1985

Hitachi, and the TLC products from CAMAG, Switzerland The dlodearray technology has taken a small step forward by the mtroductlon of Vanan’s Polychrom diode-array HPLC detector The expected Perkm-Elmer diode-array detector has not yet appeared on the scene Precision Sampling offered also a new HPLC sample changer, the LC241 DuPont did not show HPLC equipment but was very active m promotmg the Zorbax HPLC columns Tracer Instruments displayed a new spectrophotofluorlmetnc detector, Kontron showed the 2414 pump and the Autosampler 1660 Gllson displayed the new 116 UV detector, the fllterfluorlmeter 121, the precision diluter 401, the autosamplers 2211222, the sample injector 231-401, the refractive-index detector 131 and the system manager 704 ESA demonstrated a new version of detector their electrochemical Hamilton and Pharmacla had columns for special and preparative work Spectra-Physics introduced the new autosampler SP8780XR, the variable-wavelength detector SP8773 (alias the Kratos Spectroflow 773), the slmphfled SP4270-mtegrator under the type mdlcatlon SP4290, (also available m Varlan colours as Varlan 4290) and the new IBM-XT LabNet computer Bruker’s HPLC products were shown m New Orleans as IBM products under the type mdlcation LC 9533 Shlmadzu exposed the new LC-6A pump and an automatic ternary gradient system based on this pump HNU showed for the first time HPLC products the Model 65 1 pump, the UV detector 650 and a photolomzatlondetector for HPLC apphcatlons ISCO exposed the V4 variable-wavelength detector and a data system based on the Apple II computer Rdinm Instrument and Tracer showed preparative and mlcro-HPLC systems Toyo Soda’s Model 837 HPLC system 1s also meant for preparative work Miscellaneous

A lot of new smaller instruments were exposed ds Well ds the previously described equipment for the ‘mdJor dnalytlcdl currents’ The moduldr lncubdtors from Gdllenkdmp, UK,

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trends tn enalytrcal chemrstry, vol 4, no 7,1985

were shown by Curtlc Matheson Saentlflc, and Ramm showed small programmable plpettmg systems Mettler and Sartorms dominated the exhlbltlon m the field of balances Packard Instrument showed for the first time their printer/plotter and Klpp & Zonen’s BD 70/71 printer/plotter received a lot of interest BBC-GoerzMetrawatt unexpectedly introduced the Servogor 130, a three-channel recording system m an advanced (Porsche?) design Mettler mtroduced the DL-20 titration system and LECO showed an lmpresslve collection of very specialized instruments for apphcatlon m the process mdustry and m product control analysis In the field of thermal analysis Mettler showed the RC-1 Reaction Calonmeter, and Maple Instruments from the Netherlands, introduced a new version of the differential scanning calorimeter, the DCS-43, equlped with a golden oven The company

also offers a software package for thermal analysis During the Plttsburgh Conference this package was used on a portable Victor computer, but it 1s already or will soon be avallable for use with computers running under MS-DOS or CPIM operating systems It 1s lmposslble to mention all new developments m analytical equlpment, shown at this 36th Conference, so we had to make this selection The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy offered few surprises

the instrument manufacturers 1s pleasant and promlsmg The very sensitive detection systems for gas chromatography and possibly also for HPLC, based on the FT-ion mobility spectrometry are also promlsmg, although at the moment those methods by no means belong to the standard laboratory methods

Conclusions Robotlzatlon seems to be the serious business, keeping the minds of laboratory directors busy The ICP source is not only a fruitful1 source of excitation in atomic emission spectroscopy, but offers new posslblhtles m mass spectrometry too The attention paid to sample preparation by

Anatech ‘86

KLAAS H BROER Klaas H Broer’s address IS Planetenbaan 146, 3721 LE Bdthoven, The Nether1anaY.s

The contact address for mformatlon about the Anatech symposrum was madvertently mrssed from the end of the artrcle on thus topic appearing m the JunelJuly issue of TrAC It IS Professor W E van der Linden, Laboratory for Chemical Analysts, Dept of Chemical Technology, P 0 Box 217, 7500 AE Enschede, The Netherlands

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