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The Top Most-Cited and Influential Published Articles in Atrial Fibrillation from 1900 to 2019
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The Top Most-Cited and Influential Published Articles in Atrial Fibrillation from 1900 to 2019 Pulwasha Maria Iftikhar MD , Mohammad Faisal Uddin MD , Fatima Ali MD , Azeem Husain Arastu MBBS , Javidulla Khan MBBS , Maham Munawar MBBS , Javaid Suleman MD, FACC PII: DOI: Reference:
S0002-9149(19)31240-8 https://doi.org/10.1016/j.amjcard.2019.10.053 AJC 24283
To appear in:
The American Journal of Cardiology
Received date: Revised date: Accepted date:
10 August 2019 16 October 2019 28 October 2019
Please cite this article as: Pulwasha Maria Iftikhar MD , Mohammad Faisal Uddin MD , Fatima Ali MD , Azeem Husain Arastu MBBS , Javidulla Khan MBBS , Maham Munawar MBBS , Javaid Suleman MD, FACC , The Top Most-Cited and Influential Published Articles in Atrial Fibrillation from 1900 to 2019, The American Journal of Cardiology (2019), doi: https://doi.org/10.1016/j.amjcard.2019.10.053
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The Top Most-Cited and Influential Published Articles in Atrial Fibrillation from 1900 to 2019
Authors: Pulwasha Maria Iftikhar MDa, Mohammad FaisalUddin MDb, Fatima Ali MDc , Azeem Husain Arastu MBBSb, Javidulla Khan MBBSb, Maham Munawar MBBSd, Javaid Suleman MD, FACCe. a) Department of Health Sciences, St John’s University, Queens, New York
b) Department of Medicine, Deccan College of Medical Science, Hyderabad, India.
c) Department of Internal Medicine, Lincoln Medical Centre, Bronx, New York
d)
Department of Internal Medicine, Dow Medical College, Karachi.
e)
Department of Cardiology, Mount Sinai Hospital, New York, New York.
Authorship statement: Pulwasha Maria Iftikhar and Mohammad Faisal Uddin designed the study. All the authors performed the study, contributed to data extraction, literature review, analyzed the data, and wrote the paper. Financial disclosure statement: This manuscript is original research, has not been previously published and has not been submitted for publication elsewhere while under consideration. Authors declare no conflict of interest with this manuscript. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. Disclaimer: None Conflict of interest: None Corresponding Author: Pulwasha Maria Iftikhar. Institution: St John’s University, New York 1
Email: [email protected]
Abstract Citation classics are widely being implemented in the field of medical and scientific research assessment. The frequency of citation of a particular article is used to gauge its contribution and impact on the clinical world of practice and research. A thorough search of the literature showed a lack of bibliometric analysis on atrial fibrillation (AF). Thereby the main purpose of this study is to pinpoint the trend of the top 100 cited articles on AF.In June 2019, two databases, Scopus and Web of Science, were used to acquire the articles published on AF, which belonged to various genres including medicine, medical and interventional cardiology, electrophysiology and thoracic surgery. The data was thoroughly reviewed and analyzed by two reviewers with regards to the number of citations for each article, publications per area, document type, first author name, country of origin, Institute of origin and year of publication. Approval of the Institutional Board Review (IRB) was not required as we used publically available data retrospectively. The number of citations in the top 100 articles ranged from 622 to 6,641 times with an average citation of 1041.3 per article. The most significant number of articles was published in the year 2004 which ranged up to 11 in total. All the articles are published in 21 English language journals. Among these 100 articles, the most were from the United States (n=63) followed by Canada (n=24) and other countries (n=17). The top 5 institutions include McMaster University (n=9), Institut de Cardiologie de Montreal (n=8), Population Health Research Institute (n=8), Harvard Medical School (n=7), and Mayo Clinic (n=7). In conclusion, authors seeking to publish a highly referenced article on AF will be determined by source journal, the language of publication, geographic origin, methodology, or research outcome.
Key Words:
2
Atrial Fibrillation, Cardiology, Cardiothoracic Surgery, Citation Classics, Bibliometric analysis, Web of Science, Scopus.
Introduction: Atrial fibrillation (AF) is the most prevalent type of arrhythmia and it is a life-threatening condition, because it is associated with a fivefold increased chance of stroke. According to the statistics, almost 15 to 20 percent of strokes are consequence of AF are heart failure, pulmonary congestion, and cardiomyopathy [2,3]. In the United States, 2.7 million people are suffering from AF which is an underestimated figure as most of the people are either unaware or undiagnosed hence, this subject in under extensive research to prevent permanent disabilities [4]. Furthermore, various guidelines published on prevention, evaluation and management of AF has drawn attention on the subject, to successfully decrease the mortality rate [3, 4, 5]. Therefore, bibliometric analyses of AF must play a major role in this regard. Citation classics are widely being implemented in the field of medical and scientific research assessment through the involvement of the application of statistical tools to medical research publications to acquire the bibliographic for a specific subject area [6]. Although the aforementioned scientific methods of research are primarily quantitative, they are eventually used to make assertions concerning the qualitative aspects of research activities. The frequency of citation of a particular article is used to gauge its contribution and impact on the clinical world of research and practice [7]. There is a dearth of literature about the most-cited articles in the field of cardiology in general and the subject area of AF in particular. The primary objective of this study was to address this paucity, to provide clinicians, and researchers, a guide that can be practically used in the evaluation of cardiovascular and AF related literature. Citation of scientific and medical research along with other academically impactful information has been collected by the Institute for Scientific Information since the year 1945 and was made electronically accessible in the year 1979. “Science Citation Index Expanded” is the most recent system used by ISI [6, 7, 8]. This database is one of those available under the umbrella of Web of Science [9]. 3
Methods: In June 2019, two independent reviewer Iftikhar PM and Uddin FM performed a thorough database search using Scopus and Web of science for all the studies on AF which belonged to various genres including medicine, medical and interventional cardiology, and thoracic surgery. After a substantial search, both the reviewers filtered the abstracts to assemble a list of the top 100 most-cited AF articles (Table 1). In cases of disparity between the reviewers, a mutual agreement was achieved by the help of the third independent reviewer. To make a relevant list of most referenced AF articles, only studies related to the field of Cardiology, Electrophysiology, and Medicine with a main concentration of AF were included. The scientific outcome of the data that was collected as part of this study was the information pertaining to the citations frequency of the research articles, trends of the publications in the subject area of AF, authorship productivity and pattern, institution of origin, source journals, impact factors of the journals, year of publication and type and subtype of the articles. All the studies were divided into two main categories, clinical research, and basic science. Furthermore, subtypes included case reports, case series, expert opinion, control studies, cohort studies, review articles, and randomized controlled trials. Statistical analysis was done, once the data was retrieved and exported to Microsoft Excel. All the data is presented in the form of inter-quartiles (IQ) and medians. Also, the p values of 0.05 was considered significant for the included studies. Institutional Review Board (IRB) ethical approval was not required for this study, as the data was retrieved from publically available electronic databases. Only research articles published in English were included. The h-index for the collected data from Scopus is then presented. The h-index is representative of the number of times an article has been cited in order of decreasing frequency, and thus the h-graph is fundamentally a measure of the impact of a catalog of documents [10]. The h-index for this study is 100 and the impact factor (IF) of the journals included in our article was evaluated through the Journal Citation Report (Web of Knowledge) 2018 science edition (Table 2). Results: 4
In the list of 100 most-cited AF articles, the span of citations ranged from 622 to 6,641 times, and the top five articles were referenced > 3,000 times. The total number of citations for all the included articles were 104,131 with the mean citation number for each article was 1,041. Almost 461 citations were self referenced. However, the timeline of the most referenced articles was 1964-2014, and a maximum number of articles (n=35) were published between year 2,000 to 2014 and (n=11) in the year 2004 alone (Figure1). The major contributors for the top-cited and influential AF articles were the United States (n=63), Canada (n=24), and Germany (n=15) followed by Netherlands, and Italy (Figure 2). Connolly, S.J., Hihnloser, S. H., and Wolf, P.A. had the lead authorship with 9 articles each amongst the top 100 articles being analyzed, and were followed by Benjamin, E. J. with 8 articles, Pappone, C. with 7, Hart, R. G. and Nattel, S. with 6 articles each, and Haissaguerre, M. and Hocini, M. bagged 5 articles each. The top five institutions include McMaster University (n=9), Institut de Cardiologie de Montreal (n=8), Population Health Research Institute (n=8), Harvard Medical School (n=7), and Mayo Clinic (n=7) (Figure 3). Most publications that were included in this study were original studies, the types and subtypes of which have been discussed in the previous section, totaling up to 91 in number: 8 of these articles were review articles, and 1 was a conference paper. All the research articles in the list were published in 21 English journals. The articles extracted for this study stemmed from journals of Medicine, Biochemistry, Genetics and, Molecular Biology, Nursing and other multidisciplinary journals. The most-cited article (6,641) was published in the New England Journal of Medicine, and the least cited article in the list was published in Circulation journal (622). Discussion: The purpose of the bibliometric analysis is to gauge information about any certain field of interest with respect to other published scientific outcomes [11]. Therefore, it mostly makes a comparison of relevant scientific studies performed by research institutions or groups. Numerous evaluations of extensive research programs that are funded by the public have made bibliometric analysis one aspect of an integrated and thorough analytical approach, structured to measure methodology and outcomes of 5
scientific research and initiatives. However, the application of citation classics to evaluate the aggregated scientific findings across various research centers has increased the use of this information for analysis within a particular research initiative its optimal use depends on explicit context, purpose, alongside an understanding of the shortcomings and limitations [8,9,12]. A previous bibliometric analysis evaluating the publication characteristics, patterns and trends in cardiology and AF research serves as a foundation for the understanding of various ways of application of bibliometrics for the evaluation of study outcomes of clinical trials carried out in the field of cardiology in general, and AF in particular. Scopus and Web of Science are considered to be the most comprehensive citation and abstract databases to extract peer-reviewed literature in the world. Almost 41 million records are indexed in Scopus which approximately includes 18,000 titles issued by about 5,000 publishers around the world, thereby providing complete medicine coverage [9,10]. Yet another feature which sets it aside from other databases is that it brings the characteristics of PubMed and Web of Science in conjunction, this not only improves service for medical and scientific research but it is also favorable for bibliometric analysis [8,9,13,]. In this study, we observed the top 100 most cited articles on AF originated from all over the world, but most have been published in the United States. Study of the bibliometric analysis of the top 100 cited articles on AF, that development of research on AF as an interdisciplinary fraternity of research, complemented by the expansion of bibliometric methods in the last 25 years, has facilitated the scientists to make an improved assessment of geographic origins, collaboration patterns, advancement of medical content and subject areas [13,14,15,16]. Our bibliometric analysis of AF articles has described the variation and distribution of research and its outcomes over the last few decades. The results of this analysis have helped determine the starting point of impact and performance of outcomes of the research AF, from a comprehensive system of AF clinical trial studies, and the scientific impact of their publications [2,4,17,18]. The evaluation of the most frequently cited articles included in our study can serve as a comparative foundation for clinicians and scientists to the transition of trends in research on AF. Just like any other research methodology, this 6
study is not free of limitations. Nevertheless, most of the limitations of this study are similar to other bibliometric analyses, studies published in journals not listed on Scopus and Web of Science were neither searched nor made part of this study, irrespective of their contribution towards scientific productivity in the field of cardiology and AF. Moreover, the term “atrial fibrillation” was used to search for articles on the both databases and there are chances that studies published in journals that were not related to medicine, cardiology or cardiothoracic surgery might have been part of pharmacology journals, and therefore not included in the study. Another limitation is that some journals may publish conference abstracts that may be published later in a different journal and a different time as compared to the original article [19,20]. Furthermore, there is a probability of an article published a few years back to get cited and referenced is more in contrast to the articles that were published in recent years and therefore can skew the bibliographic being studied and AF articles published in English language were included, so we might have missed some highly cited articles in other languages. In conclusion, as with any bibliometric analysis, the rationale and value of this study is its reliance on the consensus of many authors and associated institutional contributions to AF investigations, analysis, diagnosis, and treatment modalities. This is the first bibliometric study that provides both qualitative and quantitative insight into AF literature. It also gives us an overview of how AF research has evolved and developed in the last few decades. Acknowledgement: I would like to express my gratitude to Dr. Arnold P. Wendroff for his encouragement and expert advice.
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References: 1. Hsieh CY, Lee CH, Wu DP, Sung SF. Characteristics and outcomes of ischemic stroke in patients with known atrial fibrillation or atrial fibrillation diagnosed after stroke. Int J Cardiol 2018; 261:68-72. 2. Kotecha D, Piccini JP. Atrial fibrillation in heart failure: what should we do?. Eur Heart J 2015; 36(46): 3250–3257. 3. Kirchhof P1, Breithardt G, Camm AJ, Crijns HJ, Kuck KH, Vardas P, Wegscheider K. Improving outcomes in patients with atrial fibrillation: rationale and design of the Early treatment of Atrial fibrillation for Stroke prevention Trial. Am Heart J 2013; 166(3):442-448. 4. Luciano AS, Renato DL. Disentangling the risk of atrial fibrillation detected after ischemic stroke (AFDAS): A real challenge in clinical practice. Int J Cardiol 2018; 261:99-100. 5. Cerasuolo JO, Cipriano LE, Sposato LA. The complexity of atrial fibrillation newly diagnosed after ischemic stroke and transient ischemic attack: advances and uncertainties. Curr Opin Neurol 2017; 30(1):28-37. 6. Garfield E. 101 Citation Classics from Annals of Internal Medicine. Curr Contents 1984; 47:313. 7. Brooke B, Nathan H, Pawlik T. Trends in the quality of highly cited surgical research over the past 20 years. Ann Surg 2009; 249:162–167. 8. Iftikhar PM, Ali F, Faisaluddin M, Khayyat A, De Gouvia De Sa M, Rao T. A Bibliometric Analysis of the Top 30 Most-cited Articles in Gestational Diabetes Mellitus Literature (19462019). Cureus 2019; 11(2), e4131.
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9. Kokol P, Vošner HB. Discrepancies among Scopus, Web of Science, and PubMed coverage of funding information in medical journal articles. JMLA 2018; 106(1):81-86. 10. Bornmann L, Daniel H: The state of h index research. Is the h index the ideal way to measure research performance? EMBO reports 2008; 10:1:2-6. 11. Vieira ES, Gomes J. A comparison of Scopus and Web of Science for a typical university. Scientometrics 2009; 81(2):587-600. 12. 100 citation classics from the Journal of the American Medical Association. Garfield E. JAMA 1987; 257:52–59. 13. Shuaib W, Khan M, Shahid H, Valdes E, Alweis R. Bibliometric analysis of the top 100 cited cardiovascular articles. Am J Cardiol 2015; 115:972-981. 14. Mao N, Wang M, Ho Y. A bibliometric study of the trend in articles related to risk assessment published in Science Citation Index. Hum Ecol Risk Asses 2010; 16(4):801-824. 15. Sengupta, I.N. & Kumari, L. Bibliometric analysis of AIDS literature. Scientometrics 1991; 20:297. 16. Ellegaard O, Wallin JA. The bibliometric analysis of scholarly production: how great is the impact? Scientometrics 2015; 105(3):1808-1831. 17. Liu YH, Wang SQ, Xue JH, Liu Y, Chen JY, Li GF, Tan N. The 100 most-cited articles on cardiovascular diseases from Mainland China. BMC Cardiovasc Disord 2015; 15:94. 18. Sweileh W. M. A bibliometric analysis of global research output on health and human rights (1900-2017). Global health research and policy 2018; 3:30. 19. Liao J, Wang J, Liu Y, Li J, He Q, Jiang W, Dong Y. The most cited articles in coronary heart disease: A bibliometric analysis between 1970 and 2015. Int J Cardiol 2016; 222:1049-1052. 19. Kolkailah A, Fugar S, Vondee N, Hirji. Bibliometric Analysis of the Top 100 Most Cited Articles in the First 50 Years of Heart Transplantation. Am J Cardiol 2019; 123(1):175-186. 20. Shao JF, Zheng XT. Hon Kon. The 100 top-cited articles published in emergency medicine journals: a bibliometric analysis. J Emerg Med 2016; 23:329–339.
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Table 1 Top Most-Cited and Influential Articles in Atrial Fibrillation
No
Article Title
Journal
1 Dabigatran versus warfarin…..
NEJM
Spontaneous initiation of atrial 2 fibrillation by ectopic beats…..
NEJM
3 Rivaroxoban versus warfarin…..
NEJM
4 Apixaban versus warfarin….. Atrial fibrillation as an independent risk factor for 5 stroke…..
NEJM
Reference No Citations 2009; 361:11391151 6641 1998; 339: 659666 5289 2011; 365: 883891 4991 2011; 365: 981992 4522
Validation of clinical classification schemes for 8 predicting stroke…..
JAMA
A comparison of rate control 9 and rhythm control…..
NEJM
1991; 22: 983-998 2001; 285:23702375 1994; 308:81106 2001; 285: 28642870 2002; 347: 18521833
Circulation
1998; 98: 946-952
Prevalence of diagnosed atrial 6 fibrillation in adults…. Collaborative overview of randomised trials of antiplatelet 7 therapy …..
Impact of atrial fibrillation on 10 the risk of death….. Refining clinical risk stratification for predicting stroke and thrombombolism in atrial 11 fibrillation….. Meta-analysis: Antithrombotic 12 therapy to prevent stroke…..
Stroke
JAMA
BMJ
Chest Ann Intern Med
2010; 137: 263272 2007; 146: 857867
4444
4248
3576
3520
3179
3072
3039
2794 12
Risk factors for stroke and efficacy of antithrombotic 13 therapy in atrial fibrillation….. Atrial fibrillation begets atrial 14 fibrillation…. A novel user-friendly score (HASBLED) to assess 1-year risk of major bleeding in patients with 15 atrialfibrillation…..
Epidemiologic features of 16 chronic atrial fibrillation….. Independent risk factors for atrial fibrillation in a population17 based cohort…..
18 Edoxaban versus warfarin….. A comparison of rate control and rhythm control in patients with recurrent persistent atrial 19 fibrillation….. Comparison of the efficacy and safety of new oral anticoagulant 20 with warfin….. Prevalence, Age Distribution, and Gender of Patients With 21 Atrial Fibrillation…..
Lancet
1994; 154: 14491457 1995; 92: 19541968 2010; 138: 10931100 1982; 306: 10181022 1994; 271: 840844 2013; 369: 20392104 2002; 347: 18341840 2002; 383: 955962 1995; 155:469473 2011; 364: 806817 2006; 114: 119125 1993; 342:12551262
Lancet
1989; 333: 175179
Arch Intern Med
Circulation
Chest
NEJM
JAMA
NEJM
NEJM
Lancet Arch Intern Med
Apixaban in patients with atrial 22 fibrillation…..
NEJM
Secular trends in incidence of 23 atrial fibrillation…..
Circulation
Secondary prevention in non24 rheumatic atrial fibrillation….. Placebo-controlled, randomised trial of warfarin and aspirin for prevention of 25 thromboembolic…..
2618
2566
2188
1940
2051
2001
1771
1770
1742
1656
1648
1583
1531
13
Stroke prevention in atrial 26 fibrillation….. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial 27 fibrillation Clopidogrel Trial…. A new approach for catheter 28 ablation of atrial fibrillation….. Prevalence, incidence, prognosis, and predisposing conditions for atrial 29 fibrillation….. The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial 30 fibrillation….. Antithrombotic therapy to prevent stroke in patients with 31 atrial fibrillation…..
Lifetime risk for development of 32 atrial fibrillation….. Warfarin versus aspirin for stroke prevention in an elderly community population with 33 atrial fibrillation….. Updated worldwide survery on the methods, efficacy, and 34 safety of catheter ablation…..
Circumferential radiofrequency 35 ablation of pulmonary vein….. Worldwide survery on the methods, efficacy, and safety of 36 catheter ablation…
Circulation
Lancet
JACC
1991; 84: 527-539 2006; 367: 19031912 2004; 43: 20442053
Circulation
1998; 82: 2N-9N 1990; 323: 15051511 1999; 131: 492501 2004; 110: 10421046
The Lancet
2007; 370: 493503
Am J Cardiol
NEJM Ann Intern Med
CircArrhythm 2010; 3: Electrophysiol 32-38 2000; 102: 2619Circulation 2682 2005; 111: 1100Circulation 1105
The natural history of atrial 37 fibrillation….
JAMA
Warfarin in the prevention of 38 stroke…..
NEJM
1995; 98: 476-484 1992; 327: 14061412
1525
1496
1482
1451
1366
1364
1278
1222
1235
1165
1096
1125
1152 14
Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial 39 fibrillation….. 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of 40 atrial fibrillation….. Prevalence, incidence and lifetime risk of atrial 41 fibrillation….. A computer model of atrial 42 fibrillation... Adjust-dose warfarin versus lowintensity, fixed-dose warfarin plus aspirin for high-risk patients 43 with atrial fibrillation….. Warfarin versus aspirin for prevention of thromboembolism 44 in atrial fibrillation….. Histologic substrate of atrial biopsies in patients with lone 45 atrial fibrillation…
Lancet
2009; 374: 534542
1162
Eurospace
2012; 14: 528-606
1135
Euro Heart J
2006; 27: 949-953
1073
Am Heart J
1964; 67: 200-220
1062
Lancet
Lancet
Circulation
New ideas about atrial 46 fibrillation…..
Nature
Canadian atrial fibrillation 47 anticoagulation…..
JACC
Incidence and risk factors for 48 atrial fibrillation…..
Circulation
Rhythm control versus rate 49 control for atrial fibrillation…..
NEJM
Rhythm or rate control on atrial 50 fibrillation….. Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial 51 fibrillation…
Lancet
NEJM
1996; 248:633638 1994; 343; 678691 1997; 96: 11801184 2002; 415: 219226 1991; 18: 349-355 1997; 96: 24552461 2008; 358: 26672677 2000; 356: 17891794 2003; 349: 10191026
1052
1046
1027
1022
1019
996
995
982
975
15
C-reactive protein elevation in patients with atrial 52 arrhythmias…..
Circulation
Adverse effect of ventricular pacing on heart failure and atrial 53 fibrillation…..
Circulation
Prevalence of atrial fibrillation in 54 elderly…
Am J Cardiol
Inflammation as a Risk Factor for 55 Atrial Fibrillation…. Electrical, contractile and structural remodeling during 56 atrial fibrillation…
Circulation Cardiovasc Res
Effect of clopidogrel added to aspirin in patients with atrial 57 fibrillation….
NEJM
Low serum thyrotropin concentrations as a risk factor or 58 atrial fibrillation…..
NEJM
Amiodarone to prevent 59 recurrence of atrial fibrillation….
NEJM
A focal source of atrial 60 fibrillation…. A population-based study of the long-term risks associated with 61 atrial fibrillation….
Circulation
Am J Med
Pulmonary vein isolation for paroxysmal and persistent atrial 62 fibrillation….
Circulation
Relationship between Sinus Rhythm, Treatment, and Survival 63 in the Atrial Fibrillation…..
Circulation
64 Chronic rapid atrial pacing…..
Circulation
2001; 104: 28862891 2003; 107: 29392937 1994; 74: 236-241 2003; 108: 30063010 2002; 54: 230-246 2009; 360: 20662078 1994; 331: 12491252 2000; 342: 913920 1997; 95: 572-576 2002; 113: 359364 2002; 105: 10771081 2004; 109: 15091513 1995; 91: 15881595
973
953
945
942
939
938
922
920
917
916
897
887
864
16
Worldwide epidemiology of 65 atrial fibrillation….. Stroke severity in atrial 66 fibrillation…. The surgical treatmen of atrial 67 fibrillation…. Effect of dronedarone on cardiovascular events in atrial 68 fibrillation…
69 Subclinical atrial fibrillation…. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non70 valvular atrial fibrillation…. Predictors of atrial fibrillation 71 after coronary artery surgery…. Electrophysiological end point for catheter ablation of atrial 72 fibrillation…. Risk of bleeding with 2 doses of dabigatran with warfarin in older and younger patients with 73 atrial fibrillation…. High-density mapping of electrically induced atrial 74 fibrillation….
NEJM
2014; 129: 837847 1996; 27: 17601764 1991; 101: 569583 2009; 360: 668678 2012; 366: 120129
Lancet
2003; 362: 16911698
Circulation
Stroke J Thorac Cardiovasc Surg
NEJM
Circulation
Circulation
Circulation
Circulation
Catheter ablation for paroxysmal 75 atrial fibrillation….. Circulation The natural history of lone atrial 76 fibrillation… Appendage obliteration to reduce stroke in cardiac surgical 77 patients…. Pulmonary vein denervation enhances long-term benefit 78 after circumferential ablation…..
NEJM Ann Thorac Surg
Circulation
1996; 94: 390-397 2000; 101: 14091417 2011; 123: 23632372 1994; 89: 16651680 2003; 108: 23552360 1987; 317: 669674 1996; 61: 755-759 2004; 109: 327334
859
853
845
844
843
839
836
817
782
768
752
756
730
744 17
circumferential pulmonary-vein ablation for chronic atrial 79 fibrillation …. Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of symtomatic atrial 80 fibrillation….. KCNQ1 gain-of-induction mutation in familial atrial 81 fibrillation….
A multicenter risk index for atrial 82 fibrillation….. Atrial fibrillation is associated with an increased risk for 83 mortality and heart failure….
Obesity and the risk of new84 onset atrial fibrillation… An analysis of the lowest effective intensity of 85 prophylactic anticoagulation….. Randomized trial of rate-control versus rhythm-control in 86 persistent atrial fibrillation…
Cryptogenic stroke and 87 underlying atrial fibrillation… Association of atrial fibrillation 88 and obstructive sleep apnea… Atrio-esophageal fistula as a complication of percutaneous transcatheter ablation of atrial 89 fibrillation…. Mortality, morbidity, and quality of life after circumferential pulmonary vein ablation for 90 atrial fibrillation….. Catheter ablation for atrial fibrillation in congestive heart 91 failure….
NEJM
JAMA
NEJM
JAMA
JACC
JAMA
NEJM
JACC
NEJM
Circulation
Circulation
JACC
NEJM
2006; 354: 934941 2005; 293: 26342640 2003; 299: 251254 2004; 291: 17201729 1998; 32: 695-703 2004; 292: 24712477 1996; 335: 540546 2003; 41: 16901696 2014; 370: 24782486 2004; 110: 364367 2004; 109: 27242726
2003; 42: 185-197 2004; 351: 23732383
728
727
723
720
718
710
711
709
709
689
680
674
669
18
92
93
94
95
96
97
98
Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation… Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation….. Ionic remodelling underlying action potential changes in a canine model of atrial fibrillation… Spatial and temporal organization during cardiac fibrillation… Treatment of artial fibrillation by ablation of localized sources….. Angiotensin II receptor blockade reduces new-onset atrial fibrillation….. Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors …..
JACC
2008; 51: 802-809
666
JAMA
2010; 303: 333340
663
Nature
1997; 81: 512-525 1998; 392: 7578
J Am College Cardiol
2012; 60: 628-636
Circ Res
JACC
JACC
Complete isolation of left atrium surrounding the pulmonary 99 veins…… Spectral analysis identifies sites of high-frequency activity 100 maintaining atrial fibrillation…..
Circulation
Circulation
2005; 45: 712-719 2005; 45: 18321839 2004; 110: 20902096 2005; 112: 789797
654
643
638
637
635
623
622
Table 2 List of Journals with Most-Cited Atrial Fibrillation articles and Their Impact Factors (IF) No.
Name of journals
No of Published Articles
Impact factor
Year
1.
Circulation
27
18.88
2017
2.
New England journal of Medicine
23
79.26
2018
3.
The Lancet
9
53.26
2017
4.
Journal of American College of Cardiology
10
19.90
2016
19
5.
Journal of American Medical Association
8
47.66
2017
6.
Archives of Internal Medicine
2
8.00
2017
7.
American Journal of Cardiology
3
3.15
2015
8.
American Journal of Medicine
1
5.00
2014
9.
Annals of Internal Medicine
2
19.38
2017
10.
Chest
2
7.65
2018
11.
Stroke
2
6.24
2018
12.
Nature
2
41.57
2018
13.
American Heat Journal
1
4.17
2018
14.
Annals of Thoracic Surgery
1
3.78
2018
15.
British Medical journal
1
23.56
2018
16.
Cardiovascular Research
1
6.29
2018
17.
Circulation Arrhythmia and Electrophysiology
1
4.72
2018
18.
Circulation Research
1
15.21
2017
19
Journal of thoracic and Cardiovascular Surgery
1
4.88
2019
20.
European Heart Journal
1
23.43
2017
21.
Europace
1
5.23
2017
20
The Top Most-Cited and Influential Published Articles in Atrial Fibrillation from 1900 to 2019 Pulwasha Maria Iftikhar MD , Mohammad Faisal Uddin MD , Fatima Ali MD , Azeem Husain Arastu MBBS , Javidulla Khan MBBS , Maham Munawar MBBS , Javaid Suleman MD, FACC PII: DOI: Reference:
S0002-9149(19)31240-8 https://doi.org/10.1016/j.amjcard.2019.10.053 AJC 24283
To appear in:
The American Journal of Cardiology
Received date: Revised date: Accepted date:
10 August 2019 16 October 2019 28 October 2019
Please cite this article as: Pulwasha Maria Iftikhar MD , Mohammad Faisal Uddin MD , Fatima Ali MD , Azeem Husain Arastu MBBS , Javidulla Khan MBBS , Maham Munawar MBBS , Javaid Suleman MD, FACC , The Top Most-Cited and Influential Published Articles in Atrial Fibrillation from 1900 to 2019, The American Journal of Cardiology (2019), doi: https://doi.org/10.1016/j.amjcard.2019.10.053
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The Top Most-Cited and Influential Published Articles in Atrial Fibrillation from 1900 to 2019
Authors: Pulwasha Maria Iftikhar MDa, Mohammad FaisalUddin MDb, Fatima Ali MDc , Azeem Husain Arastu MBBSb, Javidulla Khan MBBSb, Maham Munawar MBBSd, Javaid Suleman MD, FACCe. a) Department of Health Sciences, St John’s University, Queens, New York
b) Department of Medicine, Deccan College of Medical Science, Hyderabad, India.
c) Department of Internal Medicine, Lincoln Medical Centre, Bronx, New York
d)
Department of Internal Medicine, Dow Medical College, Karachi.
e)
Department of Cardiology, Mount Sinai Hospital, New York, New York.
Authorship statement: Pulwasha Maria Iftikhar and Mohammad Faisal Uddin designed the study. All the authors performed the study, contributed to data extraction, literature review, analyzed the data, and wrote the paper. Financial disclosure statement: This manuscript is original research, has not been previously published and has not been submitted for publication elsewhere while under consideration. Authors declare no conflict of interest with this manuscript. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. Disclaimer: None Conflict of interest: None Corresponding Author: Pulwasha Maria Iftikhar. Institution: St John’s University, New York 1
Email: [email protected]
Abstract Citation classics are widely being implemented in the field of medical and scientific research assessment. The frequency of citation of a particular article is used to gauge its contribution and impact on the clinical world of practice and research. A thorough search of the literature showed a lack of bibliometric analysis on atrial fibrillation (AF). Thereby the main purpose of this study is to pinpoint the trend of the top 100 cited articles on AF.In June 2019, two databases, Scopus and Web of Science, were used to acquire the articles published on AF, which belonged to various genres including medicine, medical and interventional cardiology, electrophysiology and thoracic surgery. The data was thoroughly reviewed and analyzed by two reviewers with regards to the number of citations for each article, publications per area, document type, first author name, country of origin, Institute of origin and year of publication. Approval of the Institutional Board Review (IRB) was not required as we used publically available data retrospectively. The number of citations in the top 100 articles ranged from 622 to 6,641 times with an average citation of 1041.3 per article. The most significant number of articles was published in the year 2004 which ranged up to 11 in total. All the articles are published in 21 English language journals. Among these 100 articles, the most were from the United States (n=63) followed by Canada (n=24) and other countries (n=17). The top 5 institutions include McMaster University (n=9), Institut de Cardiologie de Montreal (n=8), Population Health Research Institute (n=8), Harvard Medical School (n=7), and Mayo Clinic (n=7). In conclusion, authors seeking to publish a highly referenced article on AF will be determined by source journal, the language of publication, geographic origin, methodology, or research outcome.
Key Words:
2
Atrial Fibrillation, Cardiology, Cardiothoracic Surgery, Citation Classics, Bibliometric analysis, Web of Science, Scopus.
Introduction: Atrial fibrillation (AF) is the most prevalent type of arrhythmia and it is a life-threatening condition, because it is associated with a fivefold increased chance of stroke. According to the statistics, almost 15 to 20 percent of strokes are consequence of AF are heart failure, pulmonary congestion, and cardiomyopathy [2,3]. In the United States, 2.7 million people are suffering from AF which is an underestimated figure as most of the people are either unaware or undiagnosed hence, this subject in under extensive research to prevent permanent disabilities [4]. Furthermore, various guidelines published on prevention, evaluation and management of AF has drawn attention on the subject, to successfully decrease the mortality rate [3, 4, 5]. Therefore, bibliometric analyses of AF must play a major role in this regard. Citation classics are widely being implemented in the field of medical and scientific research assessment through the involvement of the application of statistical tools to medical research publications to acquire the bibliographic for a specific subject area [6]. Although the aforementioned scientific methods of research are primarily quantitative, they are eventually used to make assertions concerning the qualitative aspects of research activities. The frequency of citation of a particular article is used to gauge its contribution and impact on the clinical world of research and practice [7]. There is a dearth of literature about the most-cited articles in the field of cardiology in general and the subject area of AF in particular. The primary objective of this study was to address this paucity, to provide clinicians, and researchers, a guide that can be practically used in the evaluation of cardiovascular and AF related literature. Citation of scientific and medical research along with other academically impactful information has been collected by the Institute for Scientific Information since the year 1945 and was made electronically accessible in the year 1979. “Science Citation Index Expanded” is the most recent system used by ISI [6, 7, 8]. This database is one of those available under the umbrella of Web of Science [9]. 3
Methods: In June 2019, two independent reviewer Iftikhar PM and Uddin FM performed a thorough database search using Scopus and Web of science for all the studies on AF which belonged to various genres including medicine, medical and interventional cardiology, and thoracic surgery. After a substantial search, both the reviewers filtered the abstracts to assemble a list of the top 100 most-cited AF articles (Table 1). In cases of disparity between the reviewers, a mutual agreement was achieved by the help of the third independent reviewer. To make a relevant list of most referenced AF articles, only studies related to the field of Cardiology, Electrophysiology, and Medicine with a main concentration of AF were included. The scientific outcome of the data that was collected as part of this study was the information pertaining to the citations frequency of the research articles, trends of the publications in the subject area of AF, authorship productivity and pattern, institution of origin, source journals, impact factors of the journals, year of publication and type and subtype of the articles. All the studies were divided into two main categories, clinical research, and basic science. Furthermore, subtypes included case reports, case series, expert opinion, control studies, cohort studies, review articles, and randomized controlled trials. Statistical analysis was done, once the data was retrieved and exported to Microsoft Excel. All the data is presented in the form of inter-quartiles (IQ) and medians. Also, the p values of 0.05 was considered significant for the included studies. Institutional Review Board (IRB) ethical approval was not required for this study, as the data was retrieved from publically available electronic databases. Only research articles published in English were included. The h-index for the collected data from Scopus is then presented. The h-index is representative of the number of times an article has been cited in order of decreasing frequency, and thus the h-graph is fundamentally a measure of the impact of a catalog of documents [10]. The h-index for this study is 100 and the impact factor (IF) of the journals included in our article was evaluated through the Journal Citation Report (Web of Knowledge) 2018 science edition (Table 2). Results: 4
In the list of 100 most-cited AF articles, the span of citations ranged from 622 to 6,641 times, and the top five articles were referenced > 3,000 times. The total number of citations for all the included articles were 104,131 with the mean citation number for each article was 1,041. Almost 461 citations were self referenced. However, the timeline of the most referenced articles was 1964-2014, and a maximum number of articles (n=35) were published between year 2,000 to 2014 and (n=11) in the year 2004 alone (Figure1). The major contributors for the top-cited and influential AF articles were the United States (n=63), Canada (n=24), and Germany (n=15) followed by Netherlands, and Italy (Figure 2). Connolly, S.J., Hihnloser, S. H., and Wolf, P.A. had the lead authorship with 9 articles each amongst the top 100 articles being analyzed, and were followed by Benjamin, E. J. with 8 articles, Pappone, C. with 7, Hart, R. G. and Nattel, S. with 6 articles each, and Haissaguerre, M. and Hocini, M. bagged 5 articles each. The top five institutions include McMaster University (n=9), Institut de Cardiologie de Montreal (n=8), Population Health Research Institute (n=8), Harvard Medical School (n=7), and Mayo Clinic (n=7) (Figure 3). Most publications that were included in this study were original studies, the types and subtypes of which have been discussed in the previous section, totaling up to 91 in number: 8 of these articles were review articles, and 1 was a conference paper. All the research articles in the list were published in 21 English journals. The articles extracted for this study stemmed from journals of Medicine, Biochemistry, Genetics and, Molecular Biology, Nursing and other multidisciplinary journals. The most-cited article (6,641) was published in the New England Journal of Medicine, and the least cited article in the list was published in Circulation journal (622). Discussion: The purpose of the bibliometric analysis is to gauge information about any certain field of interest with respect to other published scientific outcomes [11]. Therefore, it mostly makes a comparison of relevant scientific studies performed by research institutions or groups. Numerous evaluations of extensive research programs that are funded by the public have made bibliometric analysis one aspect of an integrated and thorough analytical approach, structured to measure methodology and outcomes of 5
scientific research and initiatives. However, the application of citation classics to evaluate the aggregated scientific findings across various research centers has increased the use of this information for analysis within a particular research initiative its optimal use depends on explicit context, purpose, alongside an understanding of the shortcomings and limitations [8,9,12]. A previous bibliometric analysis evaluating the publication characteristics, patterns and trends in cardiology and AF research serves as a foundation for the understanding of various ways of application of bibliometrics for the evaluation of study outcomes of clinical trials carried out in the field of cardiology in general, and AF in particular. Scopus and Web of Science are considered to be the most comprehensive citation and abstract databases to extract peer-reviewed literature in the world. Almost 41 million records are indexed in Scopus which approximately includes 18,000 titles issued by about 5,000 publishers around the world, thereby providing complete medicine coverage [9,10]. Yet another feature which sets it aside from other databases is that it brings the characteristics of PubMed and Web of Science in conjunction, this not only improves service for medical and scientific research but it is also favorable for bibliometric analysis [8,9,13,]. In this study, we observed the top 100 most cited articles on AF originated from all over the world, but most have been published in the United States. Study of the bibliometric analysis of the top 100 cited articles on AF, that development of research on AF as an interdisciplinary fraternity of research, complemented by the expansion of bibliometric methods in the last 25 years, has facilitated the scientists to make an improved assessment of geographic origins, collaboration patterns, advancement of medical content and subject areas [13,14,15,16]. Our bibliometric analysis of AF articles has described the variation and distribution of research and its outcomes over the last few decades. The results of this analysis have helped determine the starting point of impact and performance of outcomes of the research AF, from a comprehensive system of AF clinical trial studies, and the scientific impact of their publications [2,4,17,18]. The evaluation of the most frequently cited articles included in our study can serve as a comparative foundation for clinicians and scientists to the transition of trends in research on AF. Just like any other research methodology, this 6
study is not free of limitations. Nevertheless, most of the limitations of this study are similar to other bibliometric analyses, studies published in journals not listed on Scopus and Web of Science were neither searched nor made part of this study, irrespective of their contribution towards scientific productivity in the field of cardiology and AF. Moreover, the term “atrial fibrillation” was used to search for articles on the both databases and there are chances that studies published in journals that were not related to medicine, cardiology or cardiothoracic surgery might have been part of pharmacology journals, and therefore not included in the study. Another limitation is that some journals may publish conference abstracts that may be published later in a different journal and a different time as compared to the original article [19,20]. Furthermore, there is a probability of an article published a few years back to get cited and referenced is more in contrast to the articles that were published in recent years and therefore can skew the bibliographic being studied and AF articles published in English language were included, so we might have missed some highly cited articles in other languages. In conclusion, as with any bibliometric analysis, the rationale and value of this study is its reliance on the consensus of many authors and associated institutional contributions to AF investigations, analysis, diagnosis, and treatment modalities. This is the first bibliometric study that provides both qualitative and quantitative insight into AF literature. It also gives us an overview of how AF research has evolved and developed in the last few decades. Acknowledgement: I would like to express my gratitude to Dr. Arnold P. Wendroff for his encouragement and expert advice.
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References: 1. Hsieh CY, Lee CH, Wu DP, Sung SF. Characteristics and outcomes of ischemic stroke in patients with known atrial fibrillation or atrial fibrillation diagnosed after stroke. Int J Cardiol 2018; 261:68-72. 2. Kotecha D, Piccini JP. Atrial fibrillation in heart failure: what should we do?. Eur Heart J 2015; 36(46): 3250–3257. 3. Kirchhof P1, Breithardt G, Camm AJ, Crijns HJ, Kuck KH, Vardas P, Wegscheider K. Improving outcomes in patients with atrial fibrillation: rationale and design of the Early treatment of Atrial fibrillation for Stroke prevention Trial. Am Heart J 2013; 166(3):442-448. 4. Luciano AS, Renato DL. Disentangling the risk of atrial fibrillation detected after ischemic stroke (AFDAS): A real challenge in clinical practice. Int J Cardiol 2018; 261:99-100. 5. Cerasuolo JO, Cipriano LE, Sposato LA. The complexity of atrial fibrillation newly diagnosed after ischemic stroke and transient ischemic attack: advances and uncertainties. Curr Opin Neurol 2017; 30(1):28-37. 6. Garfield E. 101 Citation Classics from Annals of Internal Medicine. Curr Contents 1984; 47:313. 7. Brooke B, Nathan H, Pawlik T. Trends in the quality of highly cited surgical research over the past 20 years. Ann Surg 2009; 249:162–167. 8. Iftikhar PM, Ali F, Faisaluddin M, Khayyat A, De Gouvia De Sa M, Rao T. A Bibliometric Analysis of the Top 30 Most-cited Articles in Gestational Diabetes Mellitus Literature (19462019). Cureus 2019; 11(2), e4131.
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9. Kokol P, Vošner HB. Discrepancies among Scopus, Web of Science, and PubMed coverage of funding information in medical journal articles. JMLA 2018; 106(1):81-86. 10. Bornmann L, Daniel H: The state of h index research. Is the h index the ideal way to measure research performance? EMBO reports 2008; 10:1:2-6. 11. Vieira ES, Gomes J. A comparison of Scopus and Web of Science for a typical university. Scientometrics 2009; 81(2):587-600. 12. 100 citation classics from the Journal of the American Medical Association. Garfield E. JAMA 1987; 257:52–59. 13. Shuaib W, Khan M, Shahid H, Valdes E, Alweis R. Bibliometric analysis of the top 100 cited cardiovascular articles. Am J Cardiol 2015; 115:972-981. 14. Mao N, Wang M, Ho Y. A bibliometric study of the trend in articles related to risk assessment published in Science Citation Index. Hum Ecol Risk Asses 2010; 16(4):801-824. 15. Sengupta, I.N. & Kumari, L. Bibliometric analysis of AIDS literature. Scientometrics 1991; 20:297. 16. Ellegaard O, Wallin JA. The bibliometric analysis of scholarly production: how great is the impact? Scientometrics 2015; 105(3):1808-1831. 17. Liu YH, Wang SQ, Xue JH, Liu Y, Chen JY, Li GF, Tan N. The 100 most-cited articles on cardiovascular diseases from Mainland China. BMC Cardiovasc Disord 2015; 15:94. 18. Sweileh W. M. A bibliometric analysis of global research output on health and human rights (1900-2017). Global health research and policy 2018; 3:30. 19. Liao J, Wang J, Liu Y, Li J, He Q, Jiang W, Dong Y. The most cited articles in coronary heart disease: A bibliometric analysis between 1970 and 2015. Int J Cardiol 2016; 222:1049-1052. 19. Kolkailah A, Fugar S, Vondee N, Hirji. Bibliometric Analysis of the Top 100 Most Cited Articles in the First 50 Years of Heart Transplantation. Am J Cardiol 2019; 123(1):175-186. 20. Shao JF, Zheng XT. Hon Kon. The 100 top-cited articles published in emergency medicine journals: a bibliometric analysis. J Emerg Med 2016; 23:329–339.
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Table 1 Top Most-Cited and Influential Articles in Atrial Fibrillation
No
Article Title
Journal
1 Dabigatran versus warfarin…..
NEJM
Spontaneous initiation of atrial 2 fibrillation by ectopic beats…..
NEJM
3 Rivaroxoban versus warfarin…..
NEJM
4 Apixaban versus warfarin….. Atrial fibrillation as an independent risk factor for 5 stroke…..
NEJM
Reference No Citations 2009; 361:11391151 6641 1998; 339: 659666 5289 2011; 365: 883891 4991 2011; 365: 981992 4522
Validation of clinical classification schemes for 8 predicting stroke…..
JAMA
A comparison of rate control 9 and rhythm control…..
NEJM
1991; 22: 983-998 2001; 285:23702375 1994; 308:81106 2001; 285: 28642870 2002; 347: 18521833
Circulation
1998; 98: 946-952
Prevalence of diagnosed atrial 6 fibrillation in adults…. Collaborative overview of randomised trials of antiplatelet 7 therapy …..
Impact of atrial fibrillation on 10 the risk of death….. Refining clinical risk stratification for predicting stroke and thrombombolism in atrial 11 fibrillation….. Meta-analysis: Antithrombotic 12 therapy to prevent stroke…..
Stroke
JAMA
BMJ
Chest Ann Intern Med
2010; 137: 263272 2007; 146: 857867
4444
4248
3576
3520
3179
3072
3039
2794 12
Risk factors for stroke and efficacy of antithrombotic 13 therapy in atrial fibrillation….. Atrial fibrillation begets atrial 14 fibrillation…. A novel user-friendly score (HASBLED) to assess 1-year risk of major bleeding in patients with 15 atrialfibrillation…..
Epidemiologic features of 16 chronic atrial fibrillation….. Independent risk factors for atrial fibrillation in a population17 based cohort…..
18 Edoxaban versus warfarin….. A comparison of rate control and rhythm control in patients with recurrent persistent atrial 19 fibrillation….. Comparison of the efficacy and safety of new oral anticoagulant 20 with warfin….. Prevalence, Age Distribution, and Gender of Patients With 21 Atrial Fibrillation…..
Lancet
1994; 154: 14491457 1995; 92: 19541968 2010; 138: 10931100 1982; 306: 10181022 1994; 271: 840844 2013; 369: 20392104 2002; 347: 18341840 2002; 383: 955962 1995; 155:469473 2011; 364: 806817 2006; 114: 119125 1993; 342:12551262
Lancet
1989; 333: 175179
Arch Intern Med
Circulation
Chest
NEJM
JAMA
NEJM
NEJM
Lancet Arch Intern Med
Apixaban in patients with atrial 22 fibrillation…..
NEJM
Secular trends in incidence of 23 atrial fibrillation…..
Circulation
Secondary prevention in non24 rheumatic atrial fibrillation….. Placebo-controlled, randomised trial of warfarin and aspirin for prevention of 25 thromboembolic…..
2618
2566
2188
1940
2051
2001
1771
1770
1742
1656
1648
1583
1531
13
Stroke prevention in atrial 26 fibrillation….. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial 27 fibrillation Clopidogrel Trial…. A new approach for catheter 28 ablation of atrial fibrillation….. Prevalence, incidence, prognosis, and predisposing conditions for atrial 29 fibrillation….. The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial 30 fibrillation….. Antithrombotic therapy to prevent stroke in patients with 31 atrial fibrillation…..
Lifetime risk for development of 32 atrial fibrillation….. Warfarin versus aspirin for stroke prevention in an elderly community population with 33 atrial fibrillation….. Updated worldwide survery on the methods, efficacy, and 34 safety of catheter ablation…..
Circumferential radiofrequency 35 ablation of pulmonary vein….. Worldwide survery on the methods, efficacy, and safety of 36 catheter ablation…
Circulation
Lancet
JACC
1991; 84: 527-539 2006; 367: 19031912 2004; 43: 20442053
Circulation
1998; 82: 2N-9N 1990; 323: 15051511 1999; 131: 492501 2004; 110: 10421046
The Lancet
2007; 370: 493503
Am J Cardiol
NEJM Ann Intern Med
CircArrhythm 2010; 3: Electrophysiol 32-38 2000; 102: 2619Circulation 2682 2005; 111: 1100Circulation 1105
The natural history of atrial 37 fibrillation….
JAMA
Warfarin in the prevention of 38 stroke…..
NEJM
1995; 98: 476-484 1992; 327: 14061412
1525
1496
1482
1451
1366
1364
1278
1222
1235
1165
1096
1125
1152 14
Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial 39 fibrillation….. 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of 40 atrial fibrillation….. Prevalence, incidence and lifetime risk of atrial 41 fibrillation….. A computer model of atrial 42 fibrillation... Adjust-dose warfarin versus lowintensity, fixed-dose warfarin plus aspirin for high-risk patients 43 with atrial fibrillation….. Warfarin versus aspirin for prevention of thromboembolism 44 in atrial fibrillation….. Histologic substrate of atrial biopsies in patients with lone 45 atrial fibrillation…
Lancet
2009; 374: 534542
1162
Eurospace
2012; 14: 528-606
1135
Euro Heart J
2006; 27: 949-953
1073
Am Heart J
1964; 67: 200-220
1062
Lancet
Lancet
Circulation
New ideas about atrial 46 fibrillation…..
Nature
Canadian atrial fibrillation 47 anticoagulation…..
JACC
Incidence and risk factors for 48 atrial fibrillation…..
Circulation
Rhythm control versus rate 49 control for atrial fibrillation…..
NEJM
Rhythm or rate control on atrial 50 fibrillation….. Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial 51 fibrillation…
Lancet
NEJM
1996; 248:633638 1994; 343; 678691 1997; 96: 11801184 2002; 415: 219226 1991; 18: 349-355 1997; 96: 24552461 2008; 358: 26672677 2000; 356: 17891794 2003; 349: 10191026
1052
1046
1027
1022
1019
996
995
982
975
15
C-reactive protein elevation in patients with atrial 52 arrhythmias…..
Circulation
Adverse effect of ventricular pacing on heart failure and atrial 53 fibrillation…..
Circulation
Prevalence of atrial fibrillation in 54 elderly…
Am J Cardiol
Inflammation as a Risk Factor for 55 Atrial Fibrillation…. Electrical, contractile and structural remodeling during 56 atrial fibrillation…
Circulation Cardiovasc Res
Effect of clopidogrel added to aspirin in patients with atrial 57 fibrillation….
NEJM
Low serum thyrotropin concentrations as a risk factor or 58 atrial fibrillation…..
NEJM
Amiodarone to prevent 59 recurrence of atrial fibrillation….
NEJM
A focal source of atrial 60 fibrillation…. A population-based study of the long-term risks associated with 61 atrial fibrillation….
Circulation
Am J Med
Pulmonary vein isolation for paroxysmal and persistent atrial 62 fibrillation….
Circulation
Relationship between Sinus Rhythm, Treatment, and Survival 63 in the Atrial Fibrillation…..
Circulation
64 Chronic rapid atrial pacing…..
Circulation
2001; 104: 28862891 2003; 107: 29392937 1994; 74: 236-241 2003; 108: 30063010 2002; 54: 230-246 2009; 360: 20662078 1994; 331: 12491252 2000; 342: 913920 1997; 95: 572-576 2002; 113: 359364 2002; 105: 10771081 2004; 109: 15091513 1995; 91: 15881595
973
953
945
942
939
938
922
920
917
916
897
887
864
16
Worldwide epidemiology of 65 atrial fibrillation….. Stroke severity in atrial 66 fibrillation…. The surgical treatmen of atrial 67 fibrillation…. Effect of dronedarone on cardiovascular events in atrial 68 fibrillation…
69 Subclinical atrial fibrillation…. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non70 valvular atrial fibrillation…. Predictors of atrial fibrillation 71 after coronary artery surgery…. Electrophysiological end point for catheter ablation of atrial 72 fibrillation…. Risk of bleeding with 2 doses of dabigatran with warfarin in older and younger patients with 73 atrial fibrillation…. High-density mapping of electrically induced atrial 74 fibrillation….
NEJM
2014; 129: 837847 1996; 27: 17601764 1991; 101: 569583 2009; 360: 668678 2012; 366: 120129
Lancet
2003; 362: 16911698
Circulation
Stroke J Thorac Cardiovasc Surg
NEJM
Circulation
Circulation
Circulation
Circulation
Catheter ablation for paroxysmal 75 atrial fibrillation….. Circulation The natural history of lone atrial 76 fibrillation… Appendage obliteration to reduce stroke in cardiac surgical 77 patients…. Pulmonary vein denervation enhances long-term benefit 78 after circumferential ablation…..
NEJM Ann Thorac Surg
Circulation
1996; 94: 390-397 2000; 101: 14091417 2011; 123: 23632372 1994; 89: 16651680 2003; 108: 23552360 1987; 317: 669674 1996; 61: 755-759 2004; 109: 327334
859
853
845
844
843
839
836
817
782
768
752
756
730
744 17
circumferential pulmonary-vein ablation for chronic atrial 79 fibrillation …. Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of symtomatic atrial 80 fibrillation….. KCNQ1 gain-of-induction mutation in familial atrial 81 fibrillation….
A multicenter risk index for atrial 82 fibrillation….. Atrial fibrillation is associated with an increased risk for 83 mortality and heart failure….
Obesity and the risk of new84 onset atrial fibrillation… An analysis of the lowest effective intensity of 85 prophylactic anticoagulation….. Randomized trial of rate-control versus rhythm-control in 86 persistent atrial fibrillation…
Cryptogenic stroke and 87 underlying atrial fibrillation… Association of atrial fibrillation 88 and obstructive sleep apnea… Atrio-esophageal fistula as a complication of percutaneous transcatheter ablation of atrial 89 fibrillation…. Mortality, morbidity, and quality of life after circumferential pulmonary vein ablation for 90 atrial fibrillation….. Catheter ablation for atrial fibrillation in congestive heart 91 failure….
NEJM
JAMA
NEJM
JAMA
JACC
JAMA
NEJM
JACC
NEJM
Circulation
Circulation
JACC
NEJM
2006; 354: 934941 2005; 293: 26342640 2003; 299: 251254 2004; 291: 17201729 1998; 32: 695-703 2004; 292: 24712477 1996; 335: 540546 2003; 41: 16901696 2014; 370: 24782486 2004; 110: 364367 2004; 109: 27242726
2003; 42: 185-197 2004; 351: 23732383
728
727
723
720
718
710
711
709
709
689
680
674
669
18
92
93
94
95
96
97
98
Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation… Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation….. Ionic remodelling underlying action potential changes in a canine model of atrial fibrillation… Spatial and temporal organization during cardiac fibrillation… Treatment of artial fibrillation by ablation of localized sources….. Angiotensin II receptor blockade reduces new-onset atrial fibrillation….. Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors …..
JACC
2008; 51: 802-809
666
JAMA
2010; 303: 333340
663
Nature
1997; 81: 512-525 1998; 392: 7578
J Am College Cardiol
2012; 60: 628-636
Circ Res
JACC
JACC
Complete isolation of left atrium surrounding the pulmonary 99 veins…… Spectral analysis identifies sites of high-frequency activity 100 maintaining atrial fibrillation…..
Circulation
Circulation
2005; 45: 712-719 2005; 45: 18321839 2004; 110: 20902096 2005; 112: 789797
654
643
638
637
635
623
622
Table 2 List of Journals with Most-Cited Atrial Fibrillation articles and Their Impact Factors (IF) No.
Name of journals
No of Published Articles
Impact factor
Year
1.
Circulation
27
18.88
2017
2.
New England journal of Medicine
23
79.26
2018
3.
The Lancet
9
53.26
2017
4.
Journal of American College of Cardiology
10
19.90
2016
19
5.
Journal of American Medical Association
8
47.66
2017
6.
Archives of Internal Medicine
2
8.00
2017
7.
American Journal of Cardiology
3
3.15
2015
8.
American Journal of Medicine
1
5.00
2014
9.
Annals of Internal Medicine
2
19.38
2017
10.
Chest
2
7.65
2018
11.
Stroke
2
6.24
2018
12.
Nature
2
41.57
2018
13.
American Heat Journal
1
4.17
2018
14.
Annals of Thoracic Surgery
1
3.78
2018
15.
British Medical journal
1
23.56
2018
16.
Cardiovascular Research
1
6.29
2018
17.
Circulation Arrhythmia and Electrophysiology
1
4.72
2018
18.
Circulation Research
1
15.21
2017
19
Journal of thoracic and Cardiovascular Surgery
1
4.88
2019
20.
European Heart Journal
1
23.43
2017
21.
Europace
1
5.23
2017
20