The Zondek-Aschheim test after partial hypophysectomy

912

AMERICAN JOUR-"'AL OF OBSTETRICS AND CIYNECOLOClY

I!el:lS, and sharp decline of sexual ~ensitiveness. Return of vision i:; usually slight, in some cases vision was not restored. Headaches in the nmjority of easeB hecamP notieeably lessened. These cnm1•licat ions were treated wit it hypophyseal hormor~t•s, or continuous injections of Oravi,•lan (Sterile urine from t
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Stern, D . .M.: The Zondek-Aschheim Test After Partial Hypophysectomy, Pro<.:. Roy. Soc. Med. London 27: 1501, 1931. In July, 1931, the then twenty·one-year-old patient was admitted for :;ign~ of acromegaly, bitemporal hemianopia of scotomatous type. l:lkiagram showed enlarged sella turcica. A :few days later '" large part of the anterior pituitary budy was extirpated, an adenomatouo grow! h. A year later she married, and in :Septemi.Jer, 193:l, n•alized that she wa~ pregnant. The Aschheim-Zondek reaction was fuurHI positive. Mhe passed through n normal pregnancy and was delivered in January, lt133, of a 7V:!-]JOUn.d nornml baby. The concentration of gonadotropic honnones was dl'tinitPly IJelovv normal. The reaction was negative six weeks po8tpartum. It renmins an open question whether these hormones were olerived from tltt' small fragment of remaining anterior pituitary body or hl!<1 8ollli' ot Iter ~oun·•·, "llt:h a~ embryonic trophoblast.

Arapo1f, D. A.: Homotransplantation, as a Method of Treatment of Endocrinopathies, Vcstnik Endoerinologii (.Mo0lww) 4: 439, 19iH. ln the treatment of certain endocrinopathies (such a~ ~ who had died from accidents. Glands we1·e taken from the corpse one to six huurs after death, were preserved in physiologic saline solution and kept on ice, until tlw re~ sults from iVassermann reaction >H're known. Glands wl'rl' implanted in ~uu· cutaneous tissue of abdomen or Jneast. In Jifteen cases of transplantation of testicle the method o£ Yoronoff was used. Permissimt for rwrforming tlw auto1>sy for the remontl of required gland~ \Yl!S granted hy the Prose<·uting Attornt·y in

1931. }'or transplantation of the hypophysis tlte gland of calf en1bryo, pig, and goat was used. 1'he human hypophysis was difficult to renwve. faym·able results were obtained with thyroid gland implant~.

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Allen, E., Gardner, W. V., and Diddle, A. W.: Experiments with Theelin and Galactin on Growth and Function of the Mammary Glands of the Monkey, Endocrinology 19: 305, 1935. Ten Macacus monkeys weighing from i:,;Jl1.3 to ti,O?io gm. and at various stages of sexual maturity were injected with gnladin, or prolactin, with or without previous theelin treatment. Laetation was induee<:l in four mature animals anti in one animal just reaching sexual maturity, following the injections of six to nine rabbit units of galactin or prolactin. Three of the matur<' animals possesserl onp