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Topics in carbon-13 NMR spectroscopy
193
BOOK REVIEWS
clinical ramifications of such investigations are reviewed (M. Bar&y and T. Glonek). The book ends with Part 4, a 40-page tabulation of selected “P chemical shifts and coupling constants published from 1960 to mid-1982 (D. G. Gorenstein and D. 0. Shah), and an index of key words. This book should prove to be a valuable source of information for many scientists, especially those newly entered into one of the several fields in which 3’P NMR is now useful, and who will appreciate the introductory overview of basic principles and of important recent developments. At the same time, it is written with sufficient depth and detail to warrant the attention of those with experience in NMR in general and 3’P NMR in particular. The book has one relatively minor shortcoming: a number of typographical errors, most of which are of grammatical, and not technical, consequence. RICHARD
W. BRIGGS
Departments of Radiology and Biological Chemistry The M ilton S. Hershey Medical Center The Pennsylvania State University Topics in Carbon-13 NMR Spectroscopy, Wiley, New York, 1984. 282 pp. $57.50.
Vol. 4, edited by George C. Levy.
Chapter 1 of this book, by Hull and Wehrli, is an extremely useful and interesting account of the considerations involved in the construction and use of spectrometer magnets operating at 7 to 17 tesla. Technology for superconducting magnets is described in considerable detail, and the special requirements placed on probes, rf field, and data systems by operating at ultrahigh fields and corresponding frequencies are discussed. Some applications are given at the end of the chapter, but, although impressive, these are similar to previously published material, whereas the content of the first part of the chapter is nowhere else so clearly and authoritatively presented. Chapter 2 is Woody Conover’s guide to shimming superconducting NMR magnets. In the reviewer’s laboratory, this protocol, developed originally for Nicolet Magnetics customers, has been found to be invaluable. In Chapter 3, R. E. London describes strategies for application of carbon-l 3 labels in studies of the enzyme dihydrofolate reductase, as an illustration of the general procedures and approaches to investigations utilizing labels. An extensive bibliography covering this field is provided. Chapter 4, by Sotak, Dumoulin, and Levy, deals with factors affecting quantitative accuracy in carbon-13 spectra, with major attention to methods of data analysis, including procedures for coping with problems of high dynamic range and peak overlap. In Chapter 9, Levy and Craig provide an analysis of the considerations in obtaining accurate T, values. Here, the emphasis on the choice of experimental parameters is much greater. B. C. Gerstein, in Chapter 5, discusses methods for obtaining chemical information about solids by NMR spectroscopy. An introduction to the basic principles of
194
BOOK
REVIEWS
lineshapes in solids and how these are affected by motions, both those of the sample and those of the spins, is followed by brief accounts of applications to crystalline materials, synthetic polymers, biopolymers which contain the quadrupolar nucleus nitrogen- 14, and fossil fuels. Techniques involving slow spinning, recovery of shielding anisotropy, and determination of internuclear distances are briefly treated. In Chapter 6, the methods of coherent and adiabatic rotating frame (or HartmannHahn) cross polarization as applied to liquids are described. The authors, Chingas, Garroway, and Moniz, include practical details of the use and limitations of these methods. Chapter 7 is an excellent account, by Gareth Morris, of pulsed methods for polarization transfer in liquid phase, ranging from SPT to DEPT to multiplicity determination. Closely related is Chapter 8, by Ad Bax, on 2D NMR, in which the basic procedures and applications of various types of two-dimensional experiments are presented, along with some helpful practical experimental tips. This book is packed with useful information for anyone working in carbon-l 3 NMR. It should be on the shelf of reference books beside any modem NMR spectrometer. W.S.B.
BOOK REVIEWS
clinical ramifications of such investigations are reviewed (M. Bar&y and T. Glonek). The book ends with Part 4, a 40-page tabulation of selected “P chemical shifts and coupling constants published from 1960 to mid-1982 (D. G. Gorenstein and D. 0. Shah), and an index of key words. This book should prove to be a valuable source of information for many scientists, especially those newly entered into one of the several fields in which 3’P NMR is now useful, and who will appreciate the introductory overview of basic principles and of important recent developments. At the same time, it is written with sufficient depth and detail to warrant the attention of those with experience in NMR in general and 3’P NMR in particular. The book has one relatively minor shortcoming: a number of typographical errors, most of which are of grammatical, and not technical, consequence. RICHARD
W. BRIGGS
Departments of Radiology and Biological Chemistry The M ilton S. Hershey Medical Center The Pennsylvania State University Topics in Carbon-13 NMR Spectroscopy, Wiley, New York, 1984. 282 pp. $57.50.
Vol. 4, edited by George C. Levy.
Chapter 1 of this book, by Hull and Wehrli, is an extremely useful and interesting account of the considerations involved in the construction and use of spectrometer magnets operating at 7 to 17 tesla. Technology for superconducting magnets is described in considerable detail, and the special requirements placed on probes, rf field, and data systems by operating at ultrahigh fields and corresponding frequencies are discussed. Some applications are given at the end of the chapter, but, although impressive, these are similar to previously published material, whereas the content of the first part of the chapter is nowhere else so clearly and authoritatively presented. Chapter 2 is Woody Conover’s guide to shimming superconducting NMR magnets. In the reviewer’s laboratory, this protocol, developed originally for Nicolet Magnetics customers, has been found to be invaluable. In Chapter 3, R. E. London describes strategies for application of carbon-l 3 labels in studies of the enzyme dihydrofolate reductase, as an illustration of the general procedures and approaches to investigations utilizing labels. An extensive bibliography covering this field is provided. Chapter 4, by Sotak, Dumoulin, and Levy, deals with factors affecting quantitative accuracy in carbon-13 spectra, with major attention to methods of data analysis, including procedures for coping with problems of high dynamic range and peak overlap. In Chapter 9, Levy and Craig provide an analysis of the considerations in obtaining accurate T, values. Here, the emphasis on the choice of experimental parameters is much greater. B. C. Gerstein, in Chapter 5, discusses methods for obtaining chemical information about solids by NMR spectroscopy. An introduction to the basic principles of
194
BOOK
REVIEWS
lineshapes in solids and how these are affected by motions, both those of the sample and those of the spins, is followed by brief accounts of applications to crystalline materials, synthetic polymers, biopolymers which contain the quadrupolar nucleus nitrogen- 14, and fossil fuels. Techniques involving slow spinning, recovery of shielding anisotropy, and determination of internuclear distances are briefly treated. In Chapter 6, the methods of coherent and adiabatic rotating frame (or HartmannHahn) cross polarization as applied to liquids are described. The authors, Chingas, Garroway, and Moniz, include practical details of the use and limitations of these methods. Chapter 7 is an excellent account, by Gareth Morris, of pulsed methods for polarization transfer in liquid phase, ranging from SPT to DEPT to multiplicity determination. Closely related is Chapter 8, by Ad Bax, on 2D NMR, in which the basic procedures and applications of various types of two-dimensional experiments are presented, along with some helpful practical experimental tips. This book is packed with useful information for anyone working in carbon-l 3 NMR. It should be on the shelf of reference books beside any modem NMR spectrometer. W.S.B.