Volume 24, author index, keyword index,

Experimental Gerontology VOLUME 24 INDEX 1989

PERGAMON PRESS New York • Oxford • Beijing • Frankfurt Sao Paulo • Sydney • Tokyo • Toronto

EXPERIMENTAL GERONTOLOGY EDITOR-IN-CHIEF L E O N A R D HAYFLICK, Ph.D. University of California, San Francisco School of Medicine Cell Biology and Aging Section (151 E) 4150 Clement Street, San Francisco, CA 94121 USA (415) 347-7191 TELEX: 184198 FAX: 415-495-4336 ASSOCIATE EDITORS Richard Adelman, Ph.D. Takashi Makinodan, Ph.D. Ann Arbor, MI Los Angeles, CA Stanley H. Appel, M.D. George M. Martin, M.D. Houston, TX Seattle, WA George T. Baker, III, Ph.D. Edward J. Masoro, Ph.D. Silver Spring, MD San Antonio, TX Harold Brody, Ph.D., M.D. Zhores A. Medvedev, Ph.D. Buffalo, NY London, England Alex Comfort, M.D. Joseph Meites, Ph.D. Kent, England East Lansing, MI Vincent J. Criatofalo, Ph.D. Jaime Miquel, Ph.D. Philadelphia, PA Denia, Spain Richard G. Cutler, Ph.D. Dieter Platt, M.D. Baltimore, MD NOrnberg, FRG David Danon, M.D. George S. Roth, Ph.D. Rehovot, Israel Baltimore, MD Paul M. Gallop, Ph.D. Nathan Shock, Ph.D. Boston, MA Baltimore, MD Samuel Goldstein, M.D. James R. Smith, Ph.D. Little Rock, AR Houston, TX David Harrison, Ph.D. Bernard L. Strehler, Ph.D. Bar Harbor, ME Los Angeles, CA Robin Hollidsy, Ph.D., F.R.S. Roy L. Walford, M.D. Sydney, Australia Los Angeles, CA Steven M. Horvath, Ph.D. Arthur C. Upton, M.D. Santa Barbara, CA New York, NY Alvaro Macieira-Coelho, M.D., Ph.D. Villejuif, France FOUNDING EDITOR: Dr. Alex Comfort Publishing Subscription and Advertising Offices: Pergamon Press, Inc., Fairview Park, Elmsford, NY 10523, USA; or Pergamon Press plc, Headington Hill Hall, Oxford OX3 0BX, England. Published Bimonthly. Annual institutional subscription rate (1990): DM645,00; Two year institutional rate (1990/91): DM1225.50. Persona/subscription rate for those whose library subscribes at regular rate (1989): DM133.00. Members of the American Geriatrics Society and members of the Gerontological Society of America may order personal subscriptions at a concessional rate; details of these rates are available upon request. Prices are subject to change without notice. Notify 8 weeks in advance of address change with a copy of the subscription mailing label. Back issues: Back issues of all previously published volumes, in both hard copy and on microform, are available direct from Pergamon Press offices. Copyright ~ 1989 Pergamon Press plc It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. By submitting a manuscript, the authors agree that the copyright for their article is transferred to the publisher if and when the article is accepted for publication. The copyright covers the exclusive rights to reproduce and distribute the article, including reprints, photographic reproductions, microform or any other reproductions of similar nature and translations. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, magnetic tape, mechanical photocopying, recording or otherwise, without permission in writing from the copyright holder. Photocopying information for users in the USA. The Item-Fee Code for this publication indicates that authorizationto photocopy items for internal or personal use is granted by the copyright holder for libraries and the users registered with the Copyright Clearance Center (CCC) Transactional Reporting Service provided the stated fee for copying, beyond that permitted by Section 107 or 108 of the United States Copyright Law, is paid. The appropriate remittance of $3.00 per copy per article is paid directly to the Copyright Clearance Center Inc., 27 Congress Street, Salem, MA 01970. Permission for other use. The copyright owner's consent does not extend to copying for general distribution, for promotion, for creating new works, or for resale. Specific written permission must be obtained from the publisher for copying. Please contact the Subsidiary Rights Manager, Publishing Services Dept. at either Pergamon Press pic or Pergamon Press, Inc. The Item-Fee Code for this publication is: 0531-5565/89 $3.00 + .00

Experimental Gerontology, Vol. 24, pp. VII-XVII, 1989

0531-5565/89 $3.00 + .00 Copyright © 1989 PergamonPress plc

Printed in the USA. All fights reserved.

VOLUME 24 Number 1

Age and cell density dependent changes of gangliosides in human diploid fibroblasts

TAKAKO OHSAWA

CLAUDE SEBBAN, BRIGITTE TESOLIN, BERTRAND COULOMB and PAUL BERTHAUX

11

Comparative effects of almitrine and raubasine, singly and in combination, on electroencephalographic activity in young and old rats

YASUKO ISHIKAWA, MALCOM V. GEE, BRUCE J. BAUM and GEORGE S. ROTH

25

Decreased signal transduction in rat parotid cell aggregates during aging is not due to loss of alphaladrenergic receptors

SARA ROCKWELL

37

Tumor radiation responses and tumor oxygenation in aging mice

YASUYUKI NOMURA, BEN-XIANG WANG, SHANG-BIN QI, TSUNEO NAMBA and SHUJI KANEKO

49

Biochemical changes related to aging in the senescence-accelerated mouse

HAROLD R. MASSIE, TREVOR R. WILLIAMS and LESLIE K. DEWOLFE

57

Changes in taurine in aging fruit flies and mice

ROBERT PRETZLAFF and ROBERT ARKING

67

Patterns of amino acid incorporation in long-lived genetic strains of Drosophila melanogaster

STEVEN N. AUSTAD

83

Life extension by dietary restriction in the bowl and doily spider, Frontinella pyramitela

93

Forthcoming articles

95

Announcements

Number 2

H.R. HIRSCH, J.A. COOMES and

97

M. WITTEN

The waste-product theory of aging: Transformation to unlimited growth in cell cultures

MICHAEL C. LUCE and CLIVE L. BUNN

113

Decreased accuracy of protein synthesis in extracts from aging human diploid fibroblasts

DANIEL D. BANKSON, JEROME K. ELLIS and ROBERT M. RUSSELL

127

Effects of a vitamin-A-free diet on tissue vitamin A concentration and dark adaptation of aging rats

VII

VIII

VOLUME24 INDEX

G. BENZI, F. MARZATICO, O. PASTORIS and R.F. VILLA

137

M. J. ROSENTHAL, M. VARELA, A. GARCIA and D. R. BRITTON

149 Age-related changes in the motor response to environmental novelty in the rat

T. COLOMBO, M.G. DONELLI, R. URSO, S. DALLARDA, I. BARTOSEKand A. GUAITANI

159

Doxorubicin toxicity and pharmacokinetics in old and young rats

173

Forthcoming articles

175

Announcement

Relationship between aging, drug treatment and the cerebral enzymatic antioxidant system

Number 3

NANCY L. PERILLO, ROY L. WALFORD, MARGARET A. NEWMAN and RITA B. EFFROS

177

Human T lymphocytes possess a limited in vitro life span

JOHANNES E. MENZEL and ATILLA DUNKY

189

Inhibition of complement activation in aged individuals due to increased plasma fibronectin concentration

BRYAN R. DAVIS, EUGENE BAHNIUK, JEN KUAN YOUNG, CHRISTOPHER M. BARNARD and JOSEPH M. MANSOUR

201

Age-dependent changes in the shear wave propagation through human skin

MARIO VERTECHY, MICHAEL B. COOPER, ORLANDO GHIRARDI and M. TERESA RAMACCI

211

Antioxidant enzyme activities in heart and skeletal muscle of rats of different ages

A.S. JACKS, A.R. RICHARDSONand M.A. JONES

219

A biochemical study of optic nerve myelin isolated by a micromethod from different aged rats

MAURO PROVINCIALI, MARIO MUZZIOLI and NICOLA FABRIS

227

Timing of appearance and disappearance of IFN and IL-2 induced natural immunity during ontogenetic development and aging

WAKO YUMURA, NOBUHIRO SUGINO, RYUJI NAGASAWA, SACHIHO K u s o , KATSUIKU HIROKAWA and NAOKI MARUYAMA

237

Age-associated changes in renal glomeruli of mice

RYUJI HOSONO, SUEO NISHIMOTO and SIGERU KUNO

251

Alterations of life span in the nematode

Caenorhabditis elegans under monoxenic culture conditions

F.A. LINTS, C.V. LINTS, P. BULLENS, M. BOURGOIS, and J. DEL1NCE

265

Unexplained variations in life span of the Oregon-R strain of Drosophila melanogaster over a four-year period

VOLUME24 INDEX

273

Forthcoming articles

275

Announcements

IX

Number 4

DAVID W.E. SMITH and HUBER R. WARNER

277

Review article: Does genotypic sex have a direct effect on longevity?

RICHARD HOCHSCHILD

289

Improving the precision of biological age determinations. Part 1: A new approach to calculating biological age

RICHARD HOCHSCHILD

301

Improving the precision of biological age determinations. Part 2: Automatic human tests, age norms and variability

I. Zs,-NAGY, M. OHTA and K. KITANI

317

Effect of centrophenoxine and BCE-001 treatment on lateral diffusion of proteins in the hepatocyte plasma membrane as revealed by fluorescence recovery after photobleaching in rat liver smears

M.W. HILL and J. KARTHIGASAN

331

Glucose metabolism and protein synthesis in stratified squamous epithelia from young and old mice

341

Forthcoming articles

345

Announcements

Numbers 5/6

Control of Cell Proliferation in Senescent Cells HUBER R. WARNERand EUGENIAWANG

347

Preface

Part I: Introduction HUBER R. WARNER

351

Introductory remarks

LEONARDHAYFLICK

355

Antecedents of cell aging research

VINCENT J. CR1STOFALO, DAVIDL. DOGGETT, KATHERINEM. BROOKSFREDERICHand PAUL D. PHILLIPS

367

Growth factors as probes of cell aging

Part II: Control of DNA Replication

JAMESR. SMrrH and OLIVIA M. PEREIRA-SMITH

377

Further studies on the genetic and biochemical basis of cellular senescence

X

VOLUME24 INDEX

WILLIAM PENDERGRASS,JOHN ANGELLO and THOMASH. NORWOOD

383

The relationship between cell size, the activity of DNA polymerase a and proliferative activity in human diploid fibroblast-like cell cultures

D. BUSBEE, V. SYLVIA,G. CURT[N, S. PENG, V. SRIVASTAVAand R. TILLEr

395

Age-related changes in DNA polymerase a expression

MONICA PEACO('KE, MINA YAAR and BARBARA A. GILCHREST

415

Interferon and the epidermis: Implications for cellular senescence

S. MICHALJAZWINSKI,NEJAT K. EGILMEZand JAMES B. CHEN

423

Replication control and cellular life span

FREDERICK D. COFFMANand STANLEYCOHEN

437

Aging and defective lymphoid cell activation

J. FRED DICE

451

Altered intracellular protein degradation in aging: A possible cause of proliferative arrest

S. GOLDSTEIN,S. MURANO, H. BENES, E.J. MOERMAN,R.A. JONES, R. THWEATT, R.J. SHMOOKLERREIS and B.H. HOWARD

461

Studies on the molecular-genetic basis of replicative senescence in Wemer Syndrome and normal fibroblasts

MARK J. NEULL. J. KEITH McCLUNG, JAMES R. SMITHand DAVIDB. DANNER

469

Approach to the isolation of antiproliferative genes

T. MATSUMURA,F. MALIKand R. HOLLIDAY

477

Levels of DNA methylation in diploid and SV40 transformed human fibroblasts

Part 111: Senescence-Related Changes in Gene Expression EUGENIAWANG, IOANNISK. MOUTSATSOSand TOSHITSUGU NAKAMURA

485

Cloning and molecular characterization of a cDNA clone to statin, a protein specifically expressed in nonproliferating quiescent and senescent fibroblasts

TONY GIORDANO,DON KLEINSEKand DOUGLASN. FOSTER

501

Increase in abundance of a transcript hybridizing to elongation factor 1 alpha during cellular senescence and quiescence

TARA SESHADRIand JUDITHCAMPISI

515

Growth-factor-inducible gene expression in senescent human fibroblasts

KUANG YU CHEN, ZEE-FEN CHANG, JONG-HWEI PANG, Guo-SHuN HE and ALICE Y-C LILT

523

Polyamine metabolism and cell-cycle-dependent gene expression in IMR-90 human diploid fibroblasts during senescence in culture

PETER J. HORNSBY,ROBERTF. RYAN and CHARLESY. CHENG

539

Replicative senescence and differentiated gene expression in cultured adrenocortical cells

ALBERT J.T. MILLIS, JANE SOTTILE, MARIAN HOLE, DAIVDM. MANN and VERENADIEMER

559

Collagenase production by early and late passage cultures of human fibroblasts

ELIZABETHA. COWLES, IOANNISK. MOUTSATSOS, JOHN L. WANG and RICHARDL. ANDERSON

577

Expression of carbohydrate binding protein 35 in human fibroblasts: Comparisons between cells with different proliferative capacities

VOLUME24 INDEX

587

Forthcoming articles

589

Acknowledgments

591

Announcements

595

Errata

I

Letters to the editor

V

Volume 24 Contents, Author and Key Word Index

XI

AUTHOR INDEX

Anderson, R.L., 577 Angello, J., 383 Arking, R., 67 Austad, S.N., 83 Bahniuk, E., 201 Bankson, D.D., 127 Barnard, C.M., 201 Bartosek, I., 159 Baum, B.J., 25 Benes, H., 461 Benzi, G., 137 Berthaux, P., 11 Bourgois, M., 265 Britton, D.R., 149 Brooks-Frederich, K.M., 367 BuUens, P., 265 Bunn, C.L., 113 Busbee, D., 395 Campisi, J., 515 Chang, Z-F., 523 Chen, J.B., 423 Chen, K.Y., 523 Cheng, C.Y., 539 Coffman, F.D., 437 Cohen, S., 437 Colombo, T., 159 Coomes, J.A., 97 Cooper, M.B., 211 Coulomb, B., 11 Cowles, E.A., 577 Cristfalo, V.J., 367 Curtin, G., 395 Dallarda, S., 159 Danner, D.B., 469 Davis, B.R., 201 DeWolfe, L.K., 57 Delince, J., 265 Dice, J.F., 451 Diemar, V., 559 Doggett, D.L., 367 Donelli, M.G., 159 Dunky, A., 189

Effros, R.B., 177 Egilmez, N.K., 423 Ellis, J.K., 127 Fabris, N., 227 Foster, D.N., 501 Garcia, A., 149 Gee, M.W., 25 Ghirardi, O., 211 Gilchrest, B.A., 415 Giordano, T., 501 Goldstein, S., 461 Guaitani, A., 159 Hayflick, L., 355 He, G-S., 523 Hill, M.W., 331 Hirokawa, K., 237 Hirsch, H.R., 97 Hochschild, R., 389, 301 Holliday, R., 477 Hornsby, P.J., 539 Hosono, R., 251 Howard, B.H., 461 Hoyle, M., 559 Ishikawa, Y., 25 Jacks, A.S., 219 Jazwinski, S.M., 423 Jones, M.A., 219 Jones, R. A., 461 Kaneko, S., 49 Karthigasan, J., 331 Kitani, K., 317 Kleinsek, D., 501 Kubo, S., 237 Kuno, S., 251 Lints, C.V., 265 Lints, F.A., 265 Liu, A.Y-C, 523 Luee, M.C., 113

xIII

Malik, F., 477 Mann, D.M., 559 Mansour, J.M., 201 Maruyama, N., 237 Marzatico, F., 137 Massie, H.R., 57 Matsumura, T., 477 McClung, J.K., 469 Menzel, J.E., 189 Millis, A.J.T., 559 Moerman, E.J., 461 Moutsatsos, I.K., 485,577 Murano, S., 461 Muzzioli, M., 227 Nagasawa, R., 237 Makamura, T., 485 Namba, T., 49 Newman, M.A., 177 Nishimoto, S., 251 Nomura, Y., 49 Norwood, T.H., 383 Nuell, M.J., 469 Ohsawa, T., 1 Ohta, M., 317 Pang, J-H., 523 Pastoris, O., 137 Peacocke, M., 415 Pendergrass, W., 383 Peng, S., 395 Pereira-Smith, O., 377 Perillo, N.L., 177 Phillips, P.D., 367 Pretzlaff, R., 67 Provinciali, M., 227 Qi, S.-B., 49 Ramacci, M.T., 211 Richardson, A.R., 219 Rockwell, S., 37 Rosenthal, M.J., 149 Roth, G.S., 25 Russell, R.M., 127

XIV Ryan, R.F., 539 Sebban, C., 11 Seshadri, T., 515 Shmookler Reis, R.J., 461 Smith, D.W.E., 277 Smith, J.R., 377,469 Sottile, J., 559 Srivastava, V., 395 Sugino, N., 237 Sylvia, V., 395

AUTHOR INDEX

Tesolin, B., 11 Thweatt, R., 461 Tilley, R., 395 Urso, R., 159 Varela, M., 149 Vertechy, M., 211 Villa, R.F., 137 Walford, R.L., 177

Wang, B.-X., 49 Wang, E., 347,485 Wang, J.L., 577 Warner, H.R., 277, 347, 351 Williams, T.R., 57 Witten, M., 97 Yaar, M., 415 Young, J.K., 201 Yumura, W., 237 Zs.-Nagy, I., 317

KEYWORD INDEX

adrenal cortex, 539 age-related gene expression, 423 aging and mortality, 289, 301 aging measurement, 289, 301 aging rate, 289, 301 aging rats, 219 aging, 25, 49, 67, 97, 113, 127, 137, 149, 177, 201,211,227,237, 331,395,415,437 agonists, 25 albuminuria, 237 almitrine, 11 alphal-adrenergic receptors, 25 anesthesia, 127 antiproliferative genes, 469 [3-alanine, 57 bactopeptone, 251 BCE-001,317 behavior, 149 biological age, 289, 301 biomarkers of aging, 289, 301 brain aging, 11 brain regions, 137

differentiation, 539 DNA initiation, 423 DNA polymerase ct, 383,395 DNA replication, 437 DNA synthesis inhibitors, 377, 461 doxorubicin, 159 Drosophila melanogaster, 57, 67, 265 EGF receptor, 367 electroretinogram, 127 environmental effects, 265 environmental novelty, 149 epidermis, 331 error catastrophe, 113 extracellular matrix, 201 fibroblasts, 395,515 fibronectin, 377, 469 FRAP in compact tissues, 317 frequency response, 201 functional age, 289, 301 ganglioside, 1 genetic code, 113 genetic drift, 265 genetics of aging, 67 glucose utilization, 331 glucose-6-phosphate dehydrogenase, 137 glutathione peroxidase, 211 glutathione reductase, 137,211 grooming, 149 growth control, 423 growth dynamics, 97 growth inhibition, 415 growth-related gene expression, 515

c-myc, 523 cDNA expression library, 461 Caenorhabdifis elegans, 251 calmodulin, 367 catalase, 211 CDC7, 423 cell activation, 437 cell cycle control, 423 cell cycle, 523 cell density, 1 cell hybrids, 377 cell proliferation, 515 cell size, 383 cellular aging, 1,423, 523 cellular senescence, 515 centrophenoxine, 317 chloramphenicol, 251 CNPase, 219 complement activation, 189

heat shock, 367 hepatocyte plasma membrane, 317 human T lymphocytes, 177 human diploid fibroblast, 1,383,377 hypotaurine, 57 hypoxia, 37 immune complexes, 189 IMR-90 human fibroblasts, 451 IMR-90, 1

dark adaptation, 127 dietary restriction, 83

xv

XVI in vitro aging, 383 in vitro senescence, 177,577 interferon, 227 interleukin-2, 227 isozymes, 395 keratinocytes, 415 lectins, 577 life extension, 83 life span alteration, 251 lipid, 219 lipofuscin, 49 liver perfusion, 159 liver smears, 317 locomotion, 149 long-term variations, 265 longevity, 83,265 lymphocyte aging, 437 lysosomes, 451 malondialhyde, 49 membrane hypothesis of aging, 317 membrane protein diffusion, 317 membranes, 25,367 mice, 57, 227, 331 mistranslation, 113 modified open field, 149 monoamine oxidase B, 49 monoxenic culture, 251 multivariate analysis, 201 myelin, 219 myocardium, 211 natural killer activity, 227 nematode, 251 nerves, 219 nicardipine, 137 NK cell subsets, 227 noninvasive evaluation, 201 nuclear activation, 437 nuclear proteins, 577 oral epithelium, 331 ornithine decarboxylase, 523 overexpression, 461 papaverine, 137 paromomycin, 113 parotid cells, 25 pentobarbital, 127 perfluorochemical emulsion, 37 peroxide-induced autofluorescence, 317

KEYWORD INDEX

pharmacokinetics, 159 physiological age, 289, 301 plasma fibronectin, 189 polyamines, 523 protein, 219 protein breakdown, 451 protein catabolism, 451 protein phosphorylation, 423 protein synthesis, 67 proteinuria, 237 protooncogenes, 515 quantified EEG, 11 quiescence, 461 radiation, 37 rat, 11 rats, 159 raubasine, 11 rearing, 149 renal amyloidosis, 237 renal glomerular sclerosis, 237 replication, 539 replisome, 423 reproduction, 83 retinal function, 127 RNA, 469

Saccharomyces cerevisiae, 423 sensecence factor, 423 sensecence, 67, 83,451,461,539 senescence-accelerated mouse (SAM), 49 senescent cells, 367 6-phosphogluconate dehydrogenase, 137 skeletal muscle, 211 skin, 201 solid tumors, 37 Staphylococcus aureus, 189 superoxide dismutase, 49, 137, 211 survival curve, 251 survivorship, 83 SV40, 539 T-cell cultures, 177 taurine, 57 testosterone, 49 thymidine kinase, 523 TIG-1, 1 TIG-7, 1 toxicity, 159 transformation, 97 tumor oxygenation, 37

Ic~YWOP.D INDEX

ubiquitin, 451

Werner's syndrome, 461,577 WI-38,367

vitamin A deficiency, 127 waste-product theory, 97

Zymosan, 189

XVI/