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W17-P-007 Effects of left ventricular hypertrophy on transmitral flow pattern and aortic stiffness
Workshops W17 Methods of preclinical and clinical atherosclerosis assessment
W17-P-O04 /
EFFECT OF DIET AND/OR N-3 PUFA ON PROGRESSION OF ATHEROSCLEROSIS, EVALUATED BY CAROTID PLAQUES, INTIMA MEDIA THICKNESS AND BY PULSE WAVE PROPAGATION
E.M. Hierldnn 1, M. Abdelnoor 1, L. Breivik 1, L. Bergengen 1, I. Ellingsen 2, O. Aase 3, T.O. Klemsdal 2, I. Hjermann 2, H. Araesen 3.
1Centerfor Clinical Research, 2Department of Preventive Cardiology, 3Department of Cardiology, Ullevaal University Hospital Oslo, Norway
Objective:
This randomised study targeted a comparison of the effect of 3-year diet counselling and/or long chain n-3 PUFA supplementation (2.4g/d) on the progression of atherosclerosis in carotid arteries and on finger pulse wave propagation. Methods: Measurements were assessed by High resolution B-mode ultrasound and a photopletysmographic finger pulse-sensor, respectively. Altogether, 563 elderly men with long-standing hyperlipidemia were randomised into 4 groups: controls (no dietary counselling and placebo capsules); dietary counselling (and placebo capsules); n-3 PUFA supplementation (no dietary counseBing); dietary counselling and n-3 PUFA supplementation. Results: In the diet only group, the carotid intima media thickness (IMT) increase (0.929 to 0.967mm) was significantly less than in the control group (0.909 to 0.977mm), (p=0.018). Significant increase in carotid plaques score and plaques area were observed in all 4 groups, but without between group differences. Changes in carotid IMT and in HDL-cholesterol were negatively correlated (adjusted p<0.001). Pulse wave propagation (PWP) time decreased significantly in the control group (206 to 198msec, p=0.002), reflecting reduced arterial elasticity. In the group receiving n-3 PUFA capsules only, PWP time increased significantly when compared with the control group (p=0.013). In conclusion: Reduced progression in carotid IMT was observed after dietary counselling, whereas n-3 PUFA supplementation imposed a favourable effect on arterial elasticity. These results might indicate different modes of action on vascular characteristics by the two intervention principles.
W17-P-O05 ]
RELATIONSHIP BETWEEN M O R P H O L O G I C A L FINDINGS IN CAROTID ARTERIES AND MECHANICAL PROPERTIES OF THE ARTERIAL WALL IN PATIENTS W I T H ESSENTIAL HYPERTENSION
R. Holai, B. Strauch, O. Petrak, T. Zelinka, J. Widimsky. 3rd Internal Dpt.,
1st Faculty of Med., Prague, Czech Republic Goal of the trial: To find the relationship between intima media thickness of the common carotid artery (IMT) and the pulse wave velocity (PWV) in patients with essential hypertension. Subjects and Methods: There were 38 of hypertensive patients enrolled into the study. IMT was performed using multi-frequency linear array transducer (5-10MHz) of Phillips SONOS 5500 ultrasound device. PWV was measured using the SPHYGMOCOR PMx device. Using transfer function aol~_ic pressure curve will be reconstructed. Correlation between IMT and PWV was calculated. Results: Correlation between IMT and PWV in our group of patients was relative slack (correlation coefficient was r=-0.45). These results were statistically significant (p<0.05). In conclusion: In patients with essential hypertension PWV correlates with IMT significantly but a little slackly. These results support our ideas about different influence of other cardiovascular risk factors (as dyslipidemia or smoking) on increase of arterial wall rigidity and on atherosclerotic process acceleration.
Wl
]
7-P-006 /
INFLUENCES OF AORTIC STIFFNESS AND BLOOD PRESSURE ON TARGET ORGAN DAMAGE IN HYPERTENSION
127
of aoaic stiffness and degree of blood pressure and its relationship to target organ damage were not fully elucidated. This study was undertaken to investigate the relationship between aortic stiffness, blood pressure and target organ damage in hypertension patients. Methods: Ninety-seven patients (mean age 54-t-14 years) with untreated essential hypertension were included in this study. Left ventricular mass index (LVMI) were measured by M-mode echocardiography. Indices of aortic stiffness were measured by M-mode echocardiogrnphy and were calculated from following formula: Stiffness index (SI) = In (systolic blood pressure/diastolic blood pressure)/(changes in aortic diameter/diastolic diameter); Distensibility (DI) = 2(changes in aortic diameter)/(diastolic diameter) (pulse pressure). Systolic pressure (SBP) and diastolic blood pressure (DBP) were measured at the same time. Renal function parameters were checked at the same time, including blood urea nitrogen, serum creatinine and creatinine clearance (CCr). Results: Among all patients, LVMI was significantly correlated with SBP (r = 0.387, p = 0.000), DBP (r = 0.251, p = 0.014), SI (r = 0.344, p = 0.001) and DI (r = -0.363, p = 0.000). Blood urea nitrogen was significantly correlated with SBP (r = 0.259, p = 0.013) and DI (r = -0.221, p = 0.034), and the CCr was significantly correlated with DBP (r = 0.298, p = 0.003) and DI (r = 0.417,p = 0.000). Conclusion: Our data indicated that aortic stiffness and degree of blood pressure were correlated with target organ damage. When assessing target organ damage in hypertension, not only blood pressure but also ao~c stiffness should he taken into account.
W17-P-O07]EFFECTS OF LEFT VENTRICULAR HYPERTROPHY ON TRANSMITRAL FLOW PATTERN AND AORTIC STIFFNESS C.H. Hsu 1, W.C. Tsai 1, W.T. Li 1, C.H. Lee 1, C.C. Lin 2, Y.W. Liu 1, J.Y. Chen 1, L.M. Tsai 1, L.J. Lin 1, J.H. Chen 1.1Department of Internal
Medicine, 2Department of Emergency, National Cheng Kung Medical Center, Tainan, Taiwan Objectives: Left ventricular hypertrophy can lead to diastolic dysfunction. However, the effects of left ventricular hypertrophy on aortic stiffness and its relationship to transmittal Doppler flow were not fully elucidated. This study was undertaken to investigate the relationship between transmitral Doppler flow and aortic stiffness and effect of left ventricular hypertrophy on this relationship. Methods: Eighty-three patients with untreated hypertension were inchided in this study. Transmitral Doppler flow velocity was measured from the standard four-chamber view. Indices of aortic stiffness were measured by M-mode echocardiography and stiffness index (SI) and distensibility (DI) were calculated. We divided patients into twp groups according to the presence of left ventricular hypertrophy or not. Results: Among all patients, the peak early filling velocity (E) was significantly correlated with SI (r = -0.227, p = 0.039), the peak atrial velocity (A) was significantly correlated with DI (r = -0.259, p = 0.018), and the early filling to atrial velocity ratio (E/A) was significantly correlated with SI (r = 0.233, p = 0.034). There were 21 patients with left ventricular hypertrophy and those patients had higher blood pressure, blood urea nitrogen, SI and lower DI than patients without left ventricular hypertrophy. The correlation between transmittal Doppler flow and indices of aortic stiffness were disappeared in patients with left ventricular hypertrophy. Conclusion: Our data indicated that transmittal Doppler flow pattern were correlated with aortic stiffness. The transmitral Doppler flow pattern was not only influenced by diastolic filling but also increased aftedoad. However, this phenomenon was blunted by the presence of left ventricular hypertrophy. When assessing transmitral Doppler flow pattern in hypertension, aortic stiffness should be taken into account and also the influences of left ventricular hypertrophy.
W17-P-008 J PHOSPHOLIPID TRANSFER PROTEIN ACTIVITY AND ENDOTHELIAL DYSFUNCTION IN TYPE 2 DIABETES
C.H. Hsu 1, W.C. Tsai 1, Y.Y. Huang 2, W.T. Li 1, C.H. Lee 1, Y.W. Liu 1, J.Y. Chen 1, L.M. Tsai 1, L.J. Lin 1, J.H. Chen 1.1Department oflnternal
W.S. Chow 1 A.W.K. Tso 1 S.W.M. Shiu 1, y. Wongl, V.H.G. Ai 2, K.C.B. Tan 1.1Department of Medicine, University of Hong Kong, Hong
Medicine, 2Department of Emergency, National Cheng Kung University Medical Center, Tainan, Taiwan
Kong; 2Department of Diagnostic Radiology, Queen Mary Hospital Hong Kong
Objectives: Hypertension could cause target organ damage, including left ventricular hypertrophy and renal function impairment. However, the effects
Objective: Phospholipid transfer protein (PLTP) plays an important role in HDL metabolism and reverse cholesterol transport. However, recent
75th EAS Congress, 23-26 April 2005, Prague, Czech Republic
0 I 0 -o Go
W17-P-O04 /
EFFECT OF DIET AND/OR N-3 PUFA ON PROGRESSION OF ATHEROSCLEROSIS, EVALUATED BY CAROTID PLAQUES, INTIMA MEDIA THICKNESS AND BY PULSE WAVE PROPAGATION
E.M. Hierldnn 1, M. Abdelnoor 1, L. Breivik 1, L. Bergengen 1, I. Ellingsen 2, O. Aase 3, T.O. Klemsdal 2, I. Hjermann 2, H. Araesen 3.
1Centerfor Clinical Research, 2Department of Preventive Cardiology, 3Department of Cardiology, Ullevaal University Hospital Oslo, Norway
Objective:
This randomised study targeted a comparison of the effect of 3-year diet counselling and/or long chain n-3 PUFA supplementation (2.4g/d) on the progression of atherosclerosis in carotid arteries and on finger pulse wave propagation. Methods: Measurements were assessed by High resolution B-mode ultrasound and a photopletysmographic finger pulse-sensor, respectively. Altogether, 563 elderly men with long-standing hyperlipidemia were randomised into 4 groups: controls (no dietary counselling and placebo capsules); dietary counselling (and placebo capsules); n-3 PUFA supplementation (no dietary counseBing); dietary counselling and n-3 PUFA supplementation. Results: In the diet only group, the carotid intima media thickness (IMT) increase (0.929 to 0.967mm) was significantly less than in the control group (0.909 to 0.977mm), (p=0.018). Significant increase in carotid plaques score and plaques area were observed in all 4 groups, but without between group differences. Changes in carotid IMT and in HDL-cholesterol were negatively correlated (adjusted p<0.001). Pulse wave propagation (PWP) time decreased significantly in the control group (206 to 198msec, p=0.002), reflecting reduced arterial elasticity. In the group receiving n-3 PUFA capsules only, PWP time increased significantly when compared with the control group (p=0.013). In conclusion: Reduced progression in carotid IMT was observed after dietary counselling, whereas n-3 PUFA supplementation imposed a favourable effect on arterial elasticity. These results might indicate different modes of action on vascular characteristics by the two intervention principles.
W17-P-O05 ]
RELATIONSHIP BETWEEN M O R P H O L O G I C A L FINDINGS IN CAROTID ARTERIES AND MECHANICAL PROPERTIES OF THE ARTERIAL WALL IN PATIENTS W I T H ESSENTIAL HYPERTENSION
R. Holai, B. Strauch, O. Petrak, T. Zelinka, J. Widimsky. 3rd Internal Dpt.,
1st Faculty of Med., Prague, Czech Republic Goal of the trial: To find the relationship between intima media thickness of the common carotid artery (IMT) and the pulse wave velocity (PWV) in patients with essential hypertension. Subjects and Methods: There were 38 of hypertensive patients enrolled into the study. IMT was performed using multi-frequency linear array transducer (5-10MHz) of Phillips SONOS 5500 ultrasound device. PWV was measured using the SPHYGMOCOR PMx device. Using transfer function aol~_ic pressure curve will be reconstructed. Correlation between IMT and PWV was calculated. Results: Correlation between IMT and PWV in our group of patients was relative slack (correlation coefficient was r=-0.45). These results were statistically significant (p<0.05). In conclusion: In patients with essential hypertension PWV correlates with IMT significantly but a little slackly. These results support our ideas about different influence of other cardiovascular risk factors (as dyslipidemia or smoking) on increase of arterial wall rigidity and on atherosclerotic process acceleration.
Wl
]
7-P-006 /
INFLUENCES OF AORTIC STIFFNESS AND BLOOD PRESSURE ON TARGET ORGAN DAMAGE IN HYPERTENSION
127
of aoaic stiffness and degree of blood pressure and its relationship to target organ damage were not fully elucidated. This study was undertaken to investigate the relationship between aortic stiffness, blood pressure and target organ damage in hypertension patients. Methods: Ninety-seven patients (mean age 54-t-14 years) with untreated essential hypertension were included in this study. Left ventricular mass index (LVMI) were measured by M-mode echocardiography. Indices of aortic stiffness were measured by M-mode echocardiogrnphy and were calculated from following formula: Stiffness index (SI) = In (systolic blood pressure/diastolic blood pressure)/(changes in aortic diameter/diastolic diameter); Distensibility (DI) = 2(changes in aortic diameter)/(diastolic diameter) (pulse pressure). Systolic pressure (SBP) and diastolic blood pressure (DBP) were measured at the same time. Renal function parameters were checked at the same time, including blood urea nitrogen, serum creatinine and creatinine clearance (CCr). Results: Among all patients, LVMI was significantly correlated with SBP (r = 0.387, p = 0.000), DBP (r = 0.251, p = 0.014), SI (r = 0.344, p = 0.001) and DI (r = -0.363, p = 0.000). Blood urea nitrogen was significantly correlated with SBP (r = 0.259, p = 0.013) and DI (r = -0.221, p = 0.034), and the CCr was significantly correlated with DBP (r = 0.298, p = 0.003) and DI (r = 0.417,p = 0.000). Conclusion: Our data indicated that aortic stiffness and degree of blood pressure were correlated with target organ damage. When assessing target organ damage in hypertension, not only blood pressure but also ao~c stiffness should he taken into account.
W17-P-O07]EFFECTS OF LEFT VENTRICULAR HYPERTROPHY ON TRANSMITRAL FLOW PATTERN AND AORTIC STIFFNESS C.H. Hsu 1, W.C. Tsai 1, W.T. Li 1, C.H. Lee 1, C.C. Lin 2, Y.W. Liu 1, J.Y. Chen 1, L.M. Tsai 1, L.J. Lin 1, J.H. Chen 1.1Department of Internal
Medicine, 2Department of Emergency, National Cheng Kung Medical Center, Tainan, Taiwan Objectives: Left ventricular hypertrophy can lead to diastolic dysfunction. However, the effects of left ventricular hypertrophy on aortic stiffness and its relationship to transmittal Doppler flow were not fully elucidated. This study was undertaken to investigate the relationship between transmitral Doppler flow and aortic stiffness and effect of left ventricular hypertrophy on this relationship. Methods: Eighty-three patients with untreated hypertension were inchided in this study. Transmitral Doppler flow velocity was measured from the standard four-chamber view. Indices of aortic stiffness were measured by M-mode echocardiography and stiffness index (SI) and distensibility (DI) were calculated. We divided patients into twp groups according to the presence of left ventricular hypertrophy or not. Results: Among all patients, the peak early filling velocity (E) was significantly correlated with SI (r = -0.227, p = 0.039), the peak atrial velocity (A) was significantly correlated with DI (r = -0.259, p = 0.018), and the early filling to atrial velocity ratio (E/A) was significantly correlated with SI (r = 0.233, p = 0.034). There were 21 patients with left ventricular hypertrophy and those patients had higher blood pressure, blood urea nitrogen, SI and lower DI than patients without left ventricular hypertrophy. The correlation between transmittal Doppler flow and indices of aortic stiffness were disappeared in patients with left ventricular hypertrophy. Conclusion: Our data indicated that transmittal Doppler flow pattern were correlated with aortic stiffness. The transmitral Doppler flow pattern was not only influenced by diastolic filling but also increased aftedoad. However, this phenomenon was blunted by the presence of left ventricular hypertrophy. When assessing transmitral Doppler flow pattern in hypertension, aortic stiffness should be taken into account and also the influences of left ventricular hypertrophy.
W17-P-008 J PHOSPHOLIPID TRANSFER PROTEIN ACTIVITY AND ENDOTHELIAL DYSFUNCTION IN TYPE 2 DIABETES
C.H. Hsu 1, W.C. Tsai 1, Y.Y. Huang 2, W.T. Li 1, C.H. Lee 1, Y.W. Liu 1, J.Y. Chen 1, L.M. Tsai 1, L.J. Lin 1, J.H. Chen 1.1Department oflnternal
W.S. Chow 1 A.W.K. Tso 1 S.W.M. Shiu 1, y. Wongl, V.H.G. Ai 2, K.C.B. Tan 1.1Department of Medicine, University of Hong Kong, Hong
Medicine, 2Department of Emergency, National Cheng Kung University Medical Center, Tainan, Taiwan
Kong; 2Department of Diagnostic Radiology, Queen Mary Hospital Hong Kong
Objectives: Hypertension could cause target organ damage, including left ventricular hypertrophy and renal function impairment. However, the effects
Objective: Phospholipid transfer protein (PLTP) plays an important role in HDL metabolism and reverse cholesterol transport. However, recent
75th EAS Congress, 23-26 April 2005, Prague, Czech Republic
0 I 0 -o Go