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4568547 Solid pharmaceutical compositions comprising MSM and their production
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New Patents
carbon atoms, R4 and R5 are both fluorine atoms, or wherein R4 is a chlorine atom and R5 is a hydrogen atom, and X is an oxygen or sulphur atom. The composition may be used in a dosage of 10 to 5000 g of active substance per hectare. The invention further relates to pharmaceutical compositions comprising the above compounds. Finally the invention relates to new benzoylurea compounds and to the preparation thereof.
4568543 PHARMACEUTICAL COMPOSITION CONTAINING A FIBRINOLYTIC AGENT AND A DIFFUSION FACTOR, USEFUL FOR THE TREATMENT OF MYOCARDIAL INFARCTION Francesco Borrelli, Francesc Antonetti, Rome, Italy assigned to Istituto Farmacologico Serono SpA The association of a fibrinolytic agent and of a diffusion factor has been shown very useful in the treatment of myocardial infarction. It has been shown that it is very useful to administer urokinase and hyaluronidase in the quantity ratio of at least 8 to 1, the quantity of each compound being expressed in the appropriate international units.
4568547 SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING MSM AND THEIR PRODUCTION
4568687 N-(2-4-(1H-IMIDAZOL-1YL)ALKYL)-ARYLAMIDES AND PHARMACEUTICAL COMPOSITIONS William B Wright, Jeffrey Press assigned to American Cyanamid Company This disclosure describes novel N-( omega-(1Himidazol-l-yl)alkyl)arylamides which possess the property of inhibiting the enzyme thromboxane synthetase and are also useful in the treatment of hypertension and myocardial ischemia.
4568689 PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF HYPERTENSIVE DISEASE AND MYOCARDIAL INFARCTION Ivars Y Kalvinsh, Marina L Erenshtein, Gunar A Bremanis, Valdis D Mikazhan, Maris Veveris, Edmund Y Lukevits, Edit A Pule, Anatoly S Birman, Salaspils, Union Of Soviet Socialist Republics A novel pharmaceutical preparation for the treatment of hypertensive disease and myocardial infarction, which comprises as an active ingredient, (1,1-dimethyl-3-oxopyrazolidin-l-io4-yl)acetate of the following formula: See Patent for Chemical Structure and a pharmaceutically acceptable vehicle.
Robert J Herschler Methylsulfonylmethane (MSM) is useful as a tableting and granulating aid for pharmaceutically active agents, especially those which are unstable in the presence of moisture, mixtures therewi:h being or formable into freeflowing powders or granules which are readily compressible into tablets of improved properties. A preferred method of forming such powders or granules involves mixing the pharmaceutically active agent under substantially anhydrous conditions with molten MSM or with particulate solid MSM at its softening point, cooling the resultant mixture and, when the MSM was molten, forming the solidified melt into granules or a free flowing powder and thereafter, if desired, compressing the powder or granules into tablets.
4569837 PHARMACEUTICAL PREPARATION FOR REMEDY OF PERIODONTAL DISEASE AND PROCESS FOR PRODUCTION THEREOF Yoshik Suzuki, Hiroshi Ikura, Toshihide Noguchi, Katsunori Izumizawa, Shiro Kinoshita, Hino, Japan assigned to Teijin Limited A pharmaceutical preparation for remedy of periodontal diseases, which is in the form of a film or sheet and is inserted in a periodontal pocket or gingiva, said pharmaceutical prepara-
New Patents
carbon atoms, R4 and R5 are both fluorine atoms, or wherein R4 is a chlorine atom and R5 is a hydrogen atom, and X is an oxygen or sulphur atom. The composition may be used in a dosage of 10 to 5000 g of active substance per hectare. The invention further relates to pharmaceutical compositions comprising the above compounds. Finally the invention relates to new benzoylurea compounds and to the preparation thereof.
4568543 PHARMACEUTICAL COMPOSITION CONTAINING A FIBRINOLYTIC AGENT AND A DIFFUSION FACTOR, USEFUL FOR THE TREATMENT OF MYOCARDIAL INFARCTION Francesco Borrelli, Francesc Antonetti, Rome, Italy assigned to Istituto Farmacologico Serono SpA The association of a fibrinolytic agent and of a diffusion factor has been shown very useful in the treatment of myocardial infarction. It has been shown that it is very useful to administer urokinase and hyaluronidase in the quantity ratio of at least 8 to 1, the quantity of each compound being expressed in the appropriate international units.
4568547 SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING MSM AND THEIR PRODUCTION
4568687 N-(2-4-(1H-IMIDAZOL-1YL)ALKYL)-ARYLAMIDES AND PHARMACEUTICAL COMPOSITIONS William B Wright, Jeffrey Press assigned to American Cyanamid Company This disclosure describes novel N-( omega-(1Himidazol-l-yl)alkyl)arylamides which possess the property of inhibiting the enzyme thromboxane synthetase and are also useful in the treatment of hypertension and myocardial ischemia.
4568689 PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF HYPERTENSIVE DISEASE AND MYOCARDIAL INFARCTION Ivars Y Kalvinsh, Marina L Erenshtein, Gunar A Bremanis, Valdis D Mikazhan, Maris Veveris, Edmund Y Lukevits, Edit A Pule, Anatoly S Birman, Salaspils, Union Of Soviet Socialist Republics A novel pharmaceutical preparation for the treatment of hypertensive disease and myocardial infarction, which comprises as an active ingredient, (1,1-dimethyl-3-oxopyrazolidin-l-io4-yl)acetate of the following formula: See Patent for Chemical Structure and a pharmaceutically acceptable vehicle.
Robert J Herschler Methylsulfonylmethane (MSM) is useful as a tableting and granulating aid for pharmaceutically active agents, especially those which are unstable in the presence of moisture, mixtures therewi:h being or formable into freeflowing powders or granules which are readily compressible into tablets of improved properties. A preferred method of forming such powders or granules involves mixing the pharmaceutically active agent under substantially anhydrous conditions with molten MSM or with particulate solid MSM at its softening point, cooling the resultant mixture and, when the MSM was molten, forming the solidified melt into granules or a free flowing powder and thereafter, if desired, compressing the powder or granules into tablets.
4569837 PHARMACEUTICAL PREPARATION FOR REMEDY OF PERIODONTAL DISEASE AND PROCESS FOR PRODUCTION THEREOF Yoshik Suzuki, Hiroshi Ikura, Toshihide Noguchi, Katsunori Izumizawa, Shiro Kinoshita, Hino, Japan assigned to Teijin Limited A pharmaceutical preparation for remedy of periodontal diseases, which is in the form of a film or sheet and is inserted in a periodontal pocket or gingiva, said pharmaceutical prepara-