- Email: [email protected]
Hepatitis G virus (HGV) infection in patients with chronic liver disease from Turkey
Virul
hepatitis:
clinical
213
uspects
(cos/los
1 CO6/111
HEPATITIS G V&US (HGV) INFECTION IN PATIENTS WITH CHRONIC LIVER DISEASE FROM TURKEY. E. &&an*. A.Bedir**. A.Bakan**. b. &vdkan***, M.Gtlnavdm**. *Fatih University Faculty of Medicine, Ankara, **Gndokuz Ma& University Faculty of Medicine, Samsun, and ***Baymdu Medical Center, Ankara, Turkey HGV is a newly discovered RNA virus which is possibly transmitted pareuterally. Gur objective was to determine the prevalence of HGV RNA in patients with chrouic liver disease iu Turkey. HGV RNA was detected by reverse transcriptioa polymerase chain reaction in 79 ptieuts with chronic liver disease and 60 healthy controls. There were 55 men and 24 women patients with a mean age of 45.6fl4.1 years. HGV RNA was found in 6 patients (7.6%) and in 2 controls (3.3%) @>0.05). HGV (-) HGV (+) 6 73 Number Transfusion / operation 27 5 history 50 5 Male 4 37 HBsAg 23 1 Anti-HCV 4 25 Cirrhosis 40 Chronic hepatitis 1 4 0 Minimal changes 4 1 Liver biopsy refused p>O.OS between groups Among HGV RNA positive patients, 5 cases had history transtitsion and 4 patients were HBsAg positive and 1 anti-HCV From these data, we consider that HGV RNA positive patients infected with hepatitis B or C viruses because of shared risk infection. The role of HGV infection in chronic liver disease elucidated in larger patient populations.
of blood positive. were cofactors of should be
CLINICAL FEATURES OF PATIENTS WITH CHRONIC HEPATITIS C (HCV RNA-positive, HCV AB-negative). V.T. Ivashkin*. M.V. Maevskaia*. E.A. Lukina, H. Pavlov*. E. Svsojeva. G.A. Frank. Moscow Medical Academy*, National Research Center for Haematology, Moscow, Russia. There are patients (pts) with chronic hepatitis C, with have spicial serological profile: HCV RNApositive (+),HCV Ab- negative (-). We investigated IO such pts. Age range 21 to 57 yrs. The aim was to study the clinical features of chronic hepatitis C in these pts. Merhods: Liver functional tests and liver biopsy were conducted in all; PCR was done for HCV RNA, enzyme-linked immunoassay was done for HCV Ab, haematological investigations were done. Results: a total of 10 pts have: l haematological disorders (unclear lymphoadenopathy, splenomegaly, anemia, thrombocytopenia etc); *low histological activity index (Knodell score = 3 -4 ); *normal or slightly increased serum aminotransferases. The role of virus C in these patients still should be studied.
1
ACIJ!CE REPATITIS C:CLINICAL FEATURES AND ouTCoMEs L~.Jemu~Yi~,D.DeliE,I.Bori~ic,M.Korac,P.Ni-i;0iTc’-
Institute for Infectology,MedicalUniversiti,Belgrade,Yugoslavia Qbjective:to compare the clinical features of-acute- hepatitis C(HC) and acute hepatitis B(HB),including retrospective outcomes after 12 month of follow-up.M&&:25 con-e palescents of acute HC and 25 of AVlH3were followed over one year.The diagnosis was established prospectively for groups witg te-sts for HBsAg,snti--HBcIgM, and second generation anti-HCV(AbbottHCV EIA),Resul&:HB patients were more likely to complain than those with HC for malaise(8o,6%vs.65,%), anorexia(71 8%vs.55,3%),nausea(49,Lc"bs.25,8 %),vomitingtll 2%vs.2,3%),arthralgia(206% vs.3,8%),fevert11,8%vs.2,3%),andright Apper abdominal quadrant tendemess(20,6%&.11,4 96).Mean peak bilirubin level was 1,4 times higher for HB than for HC(187.8+7.5mmol/lvs. 137.35.0 mmol/lrespectively,PG.ool).Among 25 acute HC convalescents followed for 1 year,53,7% recovered, osthepatitis hepatomegaly developed in 3, & ,CPH in 26,3%, CAH in 14,7%.The analysis of 25 convalescents of HB demonstrated ,that full recovery from HI3 occurred in82,9&he atomegaly was observed in l,%,CPH in 5,s%p ,CAH in 0,5%&0nclusions: Acute HC presents as a milder diXWZFm?t3-' HB,and has a faster acute phase.
THE COURSE OF CHRONIC HBV AND HCV INFECTION IN CHILDREN TREATED WITH INTERFERON K. Rotter. M. @lot,
A. Gladysz, K. Simon
Clinic for Infectious Diseases Medical University, Wroclaw, Poland Aim. The aim of the study was to observe the course of chronic HBV and HCV infection. in 27 children treated with interferon, Material and methods- 23 with HE3V and 4 with HCV chronic infection (age range 2 - 14 years, 10 F, 17 M., observation time from 1 to 10 years). All patients had a 2-4 - increase of ALT, positive HBV-DNA and HCV-RNA (hybridization test, MUREX)and abnormal liver biopsy. The mean level of HBV-DNA was 275lpg/ml (range 460 - 6066). All the children were tratcd with interferon (IFN) (Roferon, Roche). Treatment schedule consisted of 3 MU/t.i.w./s.c. for twenty weeks. Results In group with HBV infection HBeAgHBeAb scrownversion was observed in 7 (30,4%) children and loss of HB.Ag in 1 (4.3%). In group with HCV infection HCV-RNA was undetected in 2 children (50%). Conclusion. The efficacy of IFN therapy was good in children with HCV chronic infection and better in children with low levels of HElV-DNA during course of chronic HBV infection, The IOU level of HBV-DNA is an important predictor of spoatancxms HBeAgHBeAb scroconversion.We can expect the spontaneous HB,Ag7HB.Ab seroconversion also in long lasting inf~ons.
hepatitis:
clinical
213
uspects
(cos/los
1 CO6/111
HEPATITIS G V&US (HGV) INFECTION IN PATIENTS WITH CHRONIC LIVER DISEASE FROM TURKEY. E. &&an*. A.Bedir**. A.Bakan**. b. &vdkan***, M.Gtlnavdm**. *Fatih University Faculty of Medicine, Ankara, **Gndokuz Ma& University Faculty of Medicine, Samsun, and ***Baymdu Medical Center, Ankara, Turkey HGV is a newly discovered RNA virus which is possibly transmitted pareuterally. Gur objective was to determine the prevalence of HGV RNA in patients with chrouic liver disease iu Turkey. HGV RNA was detected by reverse transcriptioa polymerase chain reaction in 79 ptieuts with chronic liver disease and 60 healthy controls. There were 55 men and 24 women patients with a mean age of 45.6fl4.1 years. HGV RNA was found in 6 patients (7.6%) and in 2 controls (3.3%) @>0.05). HGV (-) HGV (+) 6 73 Number Transfusion / operation 27 5 history 50 5 Male 4 37 HBsAg 23 1 Anti-HCV 4 25 Cirrhosis 40 Chronic hepatitis 1 4 0 Minimal changes 4 1 Liver biopsy refused p>O.OS between groups Among HGV RNA positive patients, 5 cases had history transtitsion and 4 patients were HBsAg positive and 1 anti-HCV From these data, we consider that HGV RNA positive patients infected with hepatitis B or C viruses because of shared risk infection. The role of HGV infection in chronic liver disease elucidated in larger patient populations.
of blood positive. were cofactors of should be
CLINICAL FEATURES OF PATIENTS WITH CHRONIC HEPATITIS C (HCV RNA-positive, HCV AB-negative). V.T. Ivashkin*. M.V. Maevskaia*. E.A. Lukina, H. Pavlov*. E. Svsojeva. G.A. Frank. Moscow Medical Academy*, National Research Center for Haematology, Moscow, Russia. There are patients (pts) with chronic hepatitis C, with have spicial serological profile: HCV RNApositive (+),HCV Ab- negative (-). We investigated IO such pts. Age range 21 to 57 yrs. The aim was to study the clinical features of chronic hepatitis C in these pts. Merhods: Liver functional tests and liver biopsy were conducted in all; PCR was done for HCV RNA, enzyme-linked immunoassay was done for HCV Ab, haematological investigations were done. Results: a total of 10 pts have: l haematological disorders (unclear lymphoadenopathy, splenomegaly, anemia, thrombocytopenia etc); *low histological activity index (Knodell score = 3 -4 ); *normal or slightly increased serum aminotransferases. The role of virus C in these patients still should be studied.
1
ACIJ!CE REPATITIS C:CLINICAL FEATURES AND ouTCoMEs L~.Jemu~Yi~,D.DeliE,I.Bori~ic,M.Korac,P.Ni-i;0iTc’-
Institute for Infectology,MedicalUniversiti,Belgrade,Yugoslavia Qbjective:to compare the clinical features of-acute- hepatitis C(HC) and acute hepatitis B(HB),including retrospective outcomes after 12 month of follow-up.M&&:25 con-e palescents of acute HC and 25 of AVlH3were followed over one year.The diagnosis was established prospectively for groups witg te-sts for HBsAg,snti--HBcIgM, and second generation anti-HCV(AbbottHCV EIA),Resul&:HB patients were more likely to complain than those with HC for malaise(8o,6%vs.65,%), anorexia(71 8%vs.55,3%),nausea(49,Lc"bs.25,8 %),vomitingtll 2%vs.2,3%),arthralgia(206% vs.3,8%),fevert11,8%vs.2,3%),andright Apper abdominal quadrant tendemess(20,6%&.11,4 96).Mean peak bilirubin level was 1,4 times higher for HB than for HC(187.8+7.5mmol/lvs. 137.35.0 mmol/lrespectively,PG.ool).Among 25 acute HC convalescents followed for 1 year,53,7% recovered, osthepatitis hepatomegaly developed in 3, & ,CPH in 26,3%, CAH in 14,7%.The analysis of 25 convalescents of HB demonstrated ,that full recovery from HI3 occurred in82,9&he atomegaly was observed in l,%,CPH in 5,s%p ,CAH in 0,5%&0nclusions: Acute HC presents as a milder diXWZFm?t3-' HB,and has a faster acute phase.
THE COURSE OF CHRONIC HBV AND HCV INFECTION IN CHILDREN TREATED WITH INTERFERON K. Rotter. M. @lot,
A. Gladysz, K. Simon
Clinic for Infectious Diseases Medical University, Wroclaw, Poland Aim. The aim of the study was to observe the course of chronic HBV and HCV infection. in 27 children treated with interferon, Material and methods- 23 with HE3V and 4 with HCV chronic infection (age range 2 - 14 years, 10 F, 17 M., observation time from 1 to 10 years). All patients had a 2-4 - increase of ALT, positive HBV-DNA and HCV-RNA (hybridization test, MUREX)and abnormal liver biopsy. The mean level of HBV-DNA was 275lpg/ml (range 460 - 6066). All the children were tratcd with interferon (IFN) (Roferon, Roche). Treatment schedule consisted of 3 MU/t.i.w./s.c. for twenty weeks. Results In group with HBV infection HBeAgHBeAb scrownversion was observed in 7 (30,4%) children and loss of HB.Ag in 1 (4.3%). In group with HCV infection HCV-RNA was undetected in 2 children (50%). Conclusion. The efficacy of IFN therapy was good in children with HCV chronic infection and better in children with low levels of HElV-DNA during course of chronic HBV infection, The IOU level of HBV-DNA is an important predictor of spoatancxms HBeAgHBeAb scroconversion.We can expect the spontaneous HB,Ag7HB.Ab seroconversion also in long lasting inf~ons.