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JID VisualDx Quiz: March 2014
JID VisualDx Quiz
JID VisualDx Quiz: March 2014 Jonathan Weiss1 and Robert S. Kirsner1 Journal of Investigative Dermatology (2014) 134, e14; doi:10.1038/jid.2013.546
JID and Logical Images, Inc., have cooperated to offer the JID VisualDx Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
QUESTIONS 1. What is your diagnosis? a. Toxic epidermal necrolysis. b. Thermal burn. c. Staphylococcal scalded skin syndrome. d. Pemphigus foliaceus. e. Fixed drug eruption.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2014 The Society for Investigative Dermatology
www.jidonline.org
1
JID VisualDx Quiz
2. Which of the following is true of stress and wound healing? a. Physiologic but not psychological stress affects healing. b. Stress has been shown to slow healing in mice but not in humans. c. Acute but not chronic stress impairs healing. d. Wound healing is mediated solely by corticosteroids. e. Burn wounds induce elevated catecholamines.
3. Data from Kim et al. suggest which of the following regarding neutrophils is true? a. Prolonged neutrophil lifespan delays healing. b. Neutrophils persist because of continued migration into the wound. c. Blocking adrenergic receptors increases neutrophil presence in wounds. d. Blocking neutrophils with antibodies speeds healing in normal, nonstressed wound healing. e. IL-6 produced by keratinocytes is the prime driver of neutrophil trafficking.
TOPIC ARTICLE Questions 2 and 3 refer to the following article: Kim M-H, Gorouhi F, Ramirez S et al. (2013) Catecholamine stress alters neutrophil trafficking and impairs wound healing by β2-adrenergic receptor–mediated upregulation of IL-6. J Invest Dermatol 134:809–817
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2013.546. Additional images related to this condition and the differential diagnosis may be found at: http://info.visualdx.com/l/11412/2014-01-14/v8htc
2
Journal of Investigative Dermatology (2014), Volume 134
JID VisualDx Quiz: March 2014 Jonathan Weiss1 and Robert S. Kirsner1 Journal of Investigative Dermatology (2014) 134, e14; doi:10.1038/jid.2013.546
JID and Logical Images, Inc., have cooperated to offer the JID VisualDx Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
QUESTIONS 1. What is your diagnosis? a. Toxic epidermal necrolysis. b. Thermal burn. c. Staphylococcal scalded skin syndrome. d. Pemphigus foliaceus. e. Fixed drug eruption.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2014 The Society for Investigative Dermatology
www.jidonline.org
1
JID VisualDx Quiz
2. Which of the following is true of stress and wound healing? a. Physiologic but not psychological stress affects healing. b. Stress has been shown to slow healing in mice but not in humans. c. Acute but not chronic stress impairs healing. d. Wound healing is mediated solely by corticosteroids. e. Burn wounds induce elevated catecholamines.
3. Data from Kim et al. suggest which of the following regarding neutrophils is true? a. Prolonged neutrophil lifespan delays healing. b. Neutrophils persist because of continued migration into the wound. c. Blocking adrenergic receptors increases neutrophil presence in wounds. d. Blocking neutrophils with antibodies speeds healing in normal, nonstressed wound healing. e. IL-6 produced by keratinocytes is the prime driver of neutrophil trafficking.
TOPIC ARTICLE Questions 2 and 3 refer to the following article: Kim M-H, Gorouhi F, Ramirez S et al. (2013) Catecholamine stress alters neutrophil trafficking and impairs wound healing by β2-adrenergic receptor–mediated upregulation of IL-6. J Invest Dermatol 134:809–817
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2013.546. Additional images related to this condition and the differential diagnosis may be found at: http://info.visualdx.com/l/11412/2014-01-14/v8htc
2
Journal of Investigative Dermatology (2014), Volume 134