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Philippe Ryvlin
In Context
Lifeline Philippe Ryvlin is professor of neurology at Lyon University, France, where he obtained his MD and PhD in neurosciences. He is co-founder of the Institute for Children and Adolescents with Epilepsy (IDEE) and director of the Translational and Integrative Group in Epilepsy Research, which focuses on the pathophysiology and prevention of sudden death in patients with epilepsy. See Articles page 961
Ten most wanted August, 2011 1
Autoantibodies and CNS disease (Review, August) Vincent A, Bien CG, Irani SR, et al. Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol 2011; 10: 759–72.
2
Alzheimer’s disease (Review, September) Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer’s disease prevalence. Lancet Neurol 2011; 10: 819–28.
3
Alzheimer’s disease (Article, September) Murray ME, Graff-Radford NR, Ross OA, et al. Neuropathologically defined subtypes of Alzheimer’s disease with distinct clinical characteristics: a retrospective study. Lancet Neurol 2011; 10: 785–96.
4
Multiple sclerosis (Review, August) Kappos L, Bates D, Edan G, et al. Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring. Lancet Neurol 2011; 10: 745–58.
5
Degenerative dementias (Review, September) Pievani M, de Haan W, Wu T, et al. Functional network disruption in the degenerative dementias. Lancet Neurol 2011; 10: 829–43.
6
How would you improve the public’s understanding of research? Making research and health core subjects in children’s education.
Freezing of gait (Review, August) Nutt JG, Bloem BR, Giladi N, et al. Freezing of gait: moving forward on a mysterious clinical phenomenon. Lancet Neurol 2011; 10: 734–44.
7
What was your first experiment as a child? Trying to turn an umbrella into a parachute—a disaster.
Treatment of epilepsy in adults (Review, May) Perucca E, Tomson T. The pharmacological treatment of epilepsy in adults. Lancet Neurol 2011; 10: 446–56.
8
Mitochondiral disorders (Article, September) Suomalainen A, Elo JM, Pietiläinen KH, et al. FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study. Lancet Neurol 2011; 10: 806–18.
9
Antiepileptic drugs and pregnancy (Article, July) Tomson T, Battino D, Bonizzoni E, et al, for the EURAP study group. Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol 2011; 10: 609–17.
Which research paper has had most effect on your work, and why? The paper by Lisa Bateman and colleagues (Brain 2008; 131: 3239–45) that showed that up to a third of non-convulsive seizures are associated with ictal hypoxaemia, opening novel avenues for the understanding and prevention of seizure-induced sudden deaths. What would be your advice to a newly qualified doctor? Experience being the patient of a newly qualified doctor. What apart from your family is the passion of your life? It has changed over time, but for the past 10 years it has been kite surfing. What is your favourite film, and why? North by Northwest, the only movie I’ve seen more than a hundred times without being bored. What items do you always carry with you? None, and I am proud of that. What is your worst habit? Being late.
What one discovery or invention would most improve your life? A lifetime countdown, to help me take the right decision at the right time. What is your idea of a perfect day? 25-knot winds at Paros kite beach, Greece. What keeps you awake at night? Writing Lifeline answers for The Lancet Neurology. Do you believe there are other life forms in the Universe? Of course. If you could have dinner tonight with a famous person of your choice (dead or alive), who would it be? Roberto Benigni, the funniest man on earth.
10 Monoamine neurotransmitters (August, Review) Kurian MA, Gissen P, Smith M, et al. The monoamine neurotransmitter disorders: an expanding range of neurological syndromes. Lancet Neurol 2011; 10: 721–33. The top ten Lancet Neurology articles downloaded from ScienceDirect in August, 2011.
956
www.thelancet.com/neurology Vol 10 November 2011
Lifeline Philippe Ryvlin is professor of neurology at Lyon University, France, where he obtained his MD and PhD in neurosciences. He is co-founder of the Institute for Children and Adolescents with Epilepsy (IDEE) and director of the Translational and Integrative Group in Epilepsy Research, which focuses on the pathophysiology and prevention of sudden death in patients with epilepsy. See Articles page 961
Ten most wanted August, 2011 1
Autoantibodies and CNS disease (Review, August) Vincent A, Bien CG, Irani SR, et al. Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol 2011; 10: 759–72.
2
Alzheimer’s disease (Review, September) Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer’s disease prevalence. Lancet Neurol 2011; 10: 819–28.
3
Alzheimer’s disease (Article, September) Murray ME, Graff-Radford NR, Ross OA, et al. Neuropathologically defined subtypes of Alzheimer’s disease with distinct clinical characteristics: a retrospective study. Lancet Neurol 2011; 10: 785–96.
4
Multiple sclerosis (Review, August) Kappos L, Bates D, Edan G, et al. Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring. Lancet Neurol 2011; 10: 745–58.
5
Degenerative dementias (Review, September) Pievani M, de Haan W, Wu T, et al. Functional network disruption in the degenerative dementias. Lancet Neurol 2011; 10: 829–43.
6
How would you improve the public’s understanding of research? Making research and health core subjects in children’s education.
Freezing of gait (Review, August) Nutt JG, Bloem BR, Giladi N, et al. Freezing of gait: moving forward on a mysterious clinical phenomenon. Lancet Neurol 2011; 10: 734–44.
7
What was your first experiment as a child? Trying to turn an umbrella into a parachute—a disaster.
Treatment of epilepsy in adults (Review, May) Perucca E, Tomson T. The pharmacological treatment of epilepsy in adults. Lancet Neurol 2011; 10: 446–56.
8
Mitochondiral disorders (Article, September) Suomalainen A, Elo JM, Pietiläinen KH, et al. FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study. Lancet Neurol 2011; 10: 806–18.
9
Antiepileptic drugs and pregnancy (Article, July) Tomson T, Battino D, Bonizzoni E, et al, for the EURAP study group. Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol 2011; 10: 609–17.
Which research paper has had most effect on your work, and why? The paper by Lisa Bateman and colleagues (Brain 2008; 131: 3239–45) that showed that up to a third of non-convulsive seizures are associated with ictal hypoxaemia, opening novel avenues for the understanding and prevention of seizure-induced sudden deaths. What would be your advice to a newly qualified doctor? Experience being the patient of a newly qualified doctor. What apart from your family is the passion of your life? It has changed over time, but for the past 10 years it has been kite surfing. What is your favourite film, and why? North by Northwest, the only movie I’ve seen more than a hundred times without being bored. What items do you always carry with you? None, and I am proud of that. What is your worst habit? Being late.
What one discovery or invention would most improve your life? A lifetime countdown, to help me take the right decision at the right time. What is your idea of a perfect day? 25-knot winds at Paros kite beach, Greece. What keeps you awake at night? Writing Lifeline answers for The Lancet Neurology. Do you believe there are other life forms in the Universe? Of course. If you could have dinner tonight with a famous person of your choice (dead or alive), who would it be? Roberto Benigni, the funniest man on earth.
10 Monoamine neurotransmitters (August, Review) Kurian MA, Gissen P, Smith M, et al. The monoamine neurotransmitter disorders: an expanding range of neurological syndromes. Lancet Neurol 2011; 10: 721–33. The top ten Lancet Neurology articles downloaded from ScienceDirect in August, 2011.
956
www.thelancet.com/neurology Vol 10 November 2011