- Email: [email protected]
Preface to Volume 36
PREFACE TO VOLUME 36
The comprehensive profiling of drug substances and pharmaceutical excipients as to their physical and analytical characteristics remains essential to all phases of pharmaceutical development, and such profiles are of immeasurable importance to workers in the field. Consequently, the compilation and publication of comprehensive summaries of physical and chemical data, analytical methods, routes of compound preparation, degradation pathways, uses and applications, etc., have always been and will continue to be a vital function to both academia and industry. As the science of pharmaceutics grows and matures, the need for information similarly expands along new fronts, and this growth causes an equivalent growth in the repository sources where investigators find the information they need. The content of the Profiles series continues to respond and expand to meet this need, and so chapters are published that fall into one or more of the following main categories: 1. 2. 3. 4.
Comprehensive profiles of a drug substance or excipient Physical characterization of a drug substance or excipient Analytical methods for a drug substance or excipient Detailed discussions of the clinical uses, pharmacology, pharmacokinetics, safety, or toxicity of a drug substance or excipient 5. Reviews of methodology useful for the characterization of drug substances or excipients 6. Annual reviews of areas of importance to pharmaceutical scientists The current volume contains profiles on Buclizine, Chitin, Ezetimibe, Gemfloxacin, Glimepiride, Lornoxicam, Magnesium Silicate, and Tadalafil. The volume also contains a chapter reviewing the direct crystallization of enantiomers and dissociable diastereomers and a review of the literature published during 2009 that pertains to cocrystal systems having pharmaceutical interest. As always, I welcome communications from anyone in the pharmaceutical community who might want to provide an opinion or a contribution. Harry G. Brittain Editor, Profiles of Drug Substances, Excipients, and Related Methodology [email protected] ix
The comprehensive profiling of drug substances and pharmaceutical excipients as to their physical and analytical characteristics remains essential to all phases of pharmaceutical development, and such profiles are of immeasurable importance to workers in the field. Consequently, the compilation and publication of comprehensive summaries of physical and chemical data, analytical methods, routes of compound preparation, degradation pathways, uses and applications, etc., have always been and will continue to be a vital function to both academia and industry. As the science of pharmaceutics grows and matures, the need for information similarly expands along new fronts, and this growth causes an equivalent growth in the repository sources where investigators find the information they need. The content of the Profiles series continues to respond and expand to meet this need, and so chapters are published that fall into one or more of the following main categories: 1. 2. 3. 4.
Comprehensive profiles of a drug substance or excipient Physical characterization of a drug substance or excipient Analytical methods for a drug substance or excipient Detailed discussions of the clinical uses, pharmacology, pharmacokinetics, safety, or toxicity of a drug substance or excipient 5. Reviews of methodology useful for the characterization of drug substances or excipients 6. Annual reviews of areas of importance to pharmaceutical scientists The current volume contains profiles on Buclizine, Chitin, Ezetimibe, Gemfloxacin, Glimepiride, Lornoxicam, Magnesium Silicate, and Tadalafil. The volume also contains a chapter reviewing the direct crystallization of enantiomers and dissociable diastereomers and a review of the literature published during 2009 that pertains to cocrystal systems having pharmaceutical interest. As always, I welcome communications from anyone in the pharmaceutical community who might want to provide an opinion or a contribution. Harry G. Brittain Editor, Profiles of Drug Substances, Excipients, and Related Methodology [email protected] ix