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4886821 2 Pyridinecarbothioamides and pharmaceutical compositions comprising the same useful as anti ulcer agents
New Patents
R2, R3, R4, R5, A, B are defined as in the specification and nontoxic acid-addition salts thereof, have an excellent calcium blocking action (O-antagonist), and antihypertensive action, a platelet aggregation-inhibiting action, a phosphodiesterase inhibiting action and the like, and thus are useful as a medicine, such as a coronary vasocilator, a cerebral hyperkinemic, antihypcrtensive, thrombosis-preventing or treating agents, phosphodiesterase inhibitor or the like. Pharmaceutical compositions and methods of use are also disclosed.
4886821 2 PYRIDINECARBOTHIOAMIDES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME USEFUL AS ANTI ULCER AGENTS William A Kinney, Amadeo A Failli, Ghulam N Mir assigned to American Home Products Corporation There are provided gastric antiulcer and cytoprotective substituted N-phenyl-2 pyridinecarbothioamides. The process for their production and formulation is disclosed.
4886835 ALKADIENE DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Jean-Luc Malleron, Gerard Ponsinet, Gerard Roussel, Marcoussis, France assigned to RhonePoulenc Sante Substituted alkadienes of the formula: See Patent for Chemical Structure (I) in which R1 is hydroxy or acetoxy, R2 is hydrogen, carboxy, alkoxycarbonyl, phenyl or benzoyl, and R3 is alkylthio or alkoxy and R4 is naphthoyl or optionally substituted benzoyl, or R3 is alkoxycarbonyl, cycloalkyloxycarbonyl or cyano and R4 is alkyl, naphthyl, optionally substituted phenyl, alkylthio, naphthylmethanethio, optionally substituted benzylthio, optionally substituted phenylthio, naphthylthio, phenethylthio or allylthio, or R3 and R4 form, with the carbon atom to which they are attached, a ring-system of formula: See Patent for Chemical Structure in which
ix
R5 is hydrogen or alkoxy and X is methylene or S inhibit 5-1ipoxygenase and are useful, for example, as anti-inflammatories.
48869O7 POLYSUBSTITUTED DERIVATIVES OF NAPHTHALENE, THEIR PROCESS OF PREPARATION AND THEIR APPLICATION IN THE COSMETIC AND PHARMACEUTICAL FIELDS Braha Shroot, Jacque Eustache, Martin Bouclier, Antibes, France assigned to Centre International De Recherches Dermatologiques CIRD New polysubstituted derivatives of naphtalene. These derivatives correspond to the following formula: See Patent for Chemical Structure (I) in which: R1 to R4 is H or CH3 R5 is (i) See Patent for Chemical Structure (ii) -C triple bondN (iii) See Patent for Chemical Structure or (iv) the radical: 2-oxazolinyl m is 0 or 1 R8 is H, alkyl, O R l l , R l l being H, alkyl or See Patent for Chemical Structure R13 being alkyl or aryl or R8 is See Patent for Chemical Structure when m = l, r' and r" representing H, alkyl mono or polyhydroxyalkyl, aryl or a heterocycle when they are taken together, R9 is H or alkyl, R10 is H, alkyl and the acetals of the said compounds, See Patent for Chemical Structure -OR14, R14 being H, alkyi, mono or polyhydroxyalkyl, aryl or aralkyl a rest of a sugar or represents See Patent for Chemical Structure being 0, 1, 2, or 3 R6 represents a hydrogen atom or a lower alkyl radical, R7 represents H, alkyl, halogen, hydroxyl, sulfydryl, alkoxy, alkylthio, acyloxy, acylthio, acylamino or primary, secondary or tertiary amino and the salts of the said compounds. These compounds find an application in the cosmetic and pharmaceutical fields.
4888172 PHARMACEUTICAL FOR TREATING TUMORS AND METHODS FOR MAKING IT Emil Szebenyi, Shogen Kuslima assigned to Alfaceu Corporation Rana pipiens embryos are grown to a predetermined stage of development. The embryos
R2, R3, R4, R5, A, B are defined as in the specification and nontoxic acid-addition salts thereof, have an excellent calcium blocking action (O-antagonist), and antihypertensive action, a platelet aggregation-inhibiting action, a phosphodiesterase inhibiting action and the like, and thus are useful as a medicine, such as a coronary vasocilator, a cerebral hyperkinemic, antihypcrtensive, thrombosis-preventing or treating agents, phosphodiesterase inhibitor or the like. Pharmaceutical compositions and methods of use are also disclosed.
4886821 2 PYRIDINECARBOTHIOAMIDES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME USEFUL AS ANTI ULCER AGENTS William A Kinney, Amadeo A Failli, Ghulam N Mir assigned to American Home Products Corporation There are provided gastric antiulcer and cytoprotective substituted N-phenyl-2 pyridinecarbothioamides. The process for their production and formulation is disclosed.
4886835 ALKADIENE DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Jean-Luc Malleron, Gerard Ponsinet, Gerard Roussel, Marcoussis, France assigned to RhonePoulenc Sante Substituted alkadienes of the formula: See Patent for Chemical Structure (I) in which R1 is hydroxy or acetoxy, R2 is hydrogen, carboxy, alkoxycarbonyl, phenyl or benzoyl, and R3 is alkylthio or alkoxy and R4 is naphthoyl or optionally substituted benzoyl, or R3 is alkoxycarbonyl, cycloalkyloxycarbonyl or cyano and R4 is alkyl, naphthyl, optionally substituted phenyl, alkylthio, naphthylmethanethio, optionally substituted benzylthio, optionally substituted phenylthio, naphthylthio, phenethylthio or allylthio, or R3 and R4 form, with the carbon atom to which they are attached, a ring-system of formula: See Patent for Chemical Structure in which
ix
R5 is hydrogen or alkoxy and X is methylene or S inhibit 5-1ipoxygenase and are useful, for example, as anti-inflammatories.
48869O7 POLYSUBSTITUTED DERIVATIVES OF NAPHTHALENE, THEIR PROCESS OF PREPARATION AND THEIR APPLICATION IN THE COSMETIC AND PHARMACEUTICAL FIELDS Braha Shroot, Jacque Eustache, Martin Bouclier, Antibes, France assigned to Centre International De Recherches Dermatologiques CIRD New polysubstituted derivatives of naphtalene. These derivatives correspond to the following formula: See Patent for Chemical Structure (I) in which: R1 to R4 is H or CH3 R5 is (i) See Patent for Chemical Structure (ii) -C triple bondN (iii) See Patent for Chemical Structure or (iv) the radical: 2-oxazolinyl m is 0 or 1 R8 is H, alkyl, O R l l , R l l being H, alkyl or See Patent for Chemical Structure R13 being alkyl or aryl or R8 is See Patent for Chemical Structure when m = l, r' and r" representing H, alkyl mono or polyhydroxyalkyl, aryl or a heterocycle when they are taken together, R9 is H or alkyl, R10 is H, alkyl and the acetals of the said compounds, See Patent for Chemical Structure -OR14, R14 being H, alkyi, mono or polyhydroxyalkyl, aryl or aralkyl a rest of a sugar or represents See Patent for Chemical Structure being 0, 1, 2, or 3 R6 represents a hydrogen atom or a lower alkyl radical, R7 represents H, alkyl, halogen, hydroxyl, sulfydryl, alkoxy, alkylthio, acyloxy, acylthio, acylamino or primary, secondary or tertiary amino and the salts of the said compounds. These compounds find an application in the cosmetic and pharmaceutical fields.
4888172 PHARMACEUTICAL FOR TREATING TUMORS AND METHODS FOR MAKING IT Emil Szebenyi, Shogen Kuslima assigned to Alfaceu Corporation Rana pipiens embryos are grown to a predetermined stage of development. The embryos