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5155099 Alkylphosphonoserines and pharmaceutical compositions useful as cytostatic agents
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New Patents
product to be dispensed, and returning by elasticity into contact with the seat when the dispensing stops. The obturator is subjected to the action of a constraining element tending to keep it applied to the seat wherewith it cooperates.
5154923 POLYPEPTIDES AND DERIVATIVES THEREOF AS WELL AS THEIR USE IN PHARMACEUTICAL AND DIAGNOSTIC COMPOSITIONS Willem Van Eden, Johannes D A Van Embden, Zee Ruurd Van der, Irun R Cohen, Bilthoven, Netherlands assigned to De Staat Der Nederlanden Vertegenwoordigd Door de Minister Van Welzijn Volksgezondheid En Cultuur; Rijksuniversiteit Te UtrechtYeda Research and Development Co Ltd A polypeptide having amino acid sequence 172192 of a Mycobaeterium bovis BCG 64 kD polypeptide, said sequence having the formula See Patent for Chemical Structure as well as polypeptides derived therefrom, in the amino acid sequence of which sequence 172-179 and/or sequence 189-192 is (are) entirely or partially absent, were found to be useful as immunogens inducing resistance to auto-immune arthritis and similar auto-immune diseases. The invention relates to these polypeptides, to polypeptides showing sequential homology with these polypeptides, and to derivatives and multimers thereof. Also, microorganisms expressing the polypeptides either as such or as part of a fusion protein or as a multimer form part of the invention. Finally, the invention relates to pharmaceutical compositions, diagnostic compositions and test kits comprising a compound according to the invention.
5155098 N-HETEROARYL -PURIN-6AMINES, AND PHARMACEUTICAL COMPOSITIONS AND METHODS EMPLOYING THEM
Structure where R1 is hydrogen, lower alkyl, and arylloweralkyl; R2 and R3 are independently hydrogen, lower alkyl or R2 and R3 taken together are aryl; R4 and R5 are independently hydrogen, lower alkyl, or R4 and R5 taken together are aryl; R6 is hydrogen, lower alkyl, aryl, aryUoweralkyl, See Patent for Chemical Structure where R2, R3, R4 and R5 are as defined above, and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic and anitconvulsant agents.
5155099 ALKYLPHOSPHONOSERINES AND PHARMACEUTICAL COMPOSITIONS USEFUL AS CYTOSTATIC AGENTS Hans Brachwitz, Reinhild Schonfeld, Peter Langen, Friedrich Paltauf, Albin Hermetter, Berlin, Federal Republic Of Germany assigned to Hafslund Nycomed Pharma Aktiengesellschaft Compounds of formula I See Patent for Chemical Structure in which R denotes a straightchain or branched, saturated or unsaturated aliphatic hydrocarbon radical having 6-30 C atoms wich may optionally be substituted by halogen or the radicals OR1, SR1 or NR1R2, where R1 and R2 in each case denote a hydrogen atom or an alkyl or acyl radical having 1-6 C atoms which have excellent virustatic and cytostatic action.
5155102 1-ALKYL-3-(ACYLAMINO)EPSILON-CAPROLACTAMES AS ENHANCERS OF LEARNING AND MEMORY AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
Richard Eft]and, Joseph T Klein, Larr Davis, Gordon E Olson assigned to Hoechst-Roussel Pharmaceuticals Inc
Fabio Giannessi, Orlando Ghirardi, Domenico Misiti, Maria O Tinti, Roberto Cozzolino, Carlo Scolastico, ,nilreB assigned to Sigrna-Tau Industrie Farmaceutiche Riunite S p A
This invention relates to a N-heteroaryl-purin-6amine of the formula See Patent for Chemical
1-alkyl-3-(acylamino)- epsilon-caprolactames of formula (1) See Patent for Chemical Structure (1)
New Patents
product to be dispensed, and returning by elasticity into contact with the seat when the dispensing stops. The obturator is subjected to the action of a constraining element tending to keep it applied to the seat wherewith it cooperates.
5154923 POLYPEPTIDES AND DERIVATIVES THEREOF AS WELL AS THEIR USE IN PHARMACEUTICAL AND DIAGNOSTIC COMPOSITIONS Willem Van Eden, Johannes D A Van Embden, Zee Ruurd Van der, Irun R Cohen, Bilthoven, Netherlands assigned to De Staat Der Nederlanden Vertegenwoordigd Door de Minister Van Welzijn Volksgezondheid En Cultuur; Rijksuniversiteit Te UtrechtYeda Research and Development Co Ltd A polypeptide having amino acid sequence 172192 of a Mycobaeterium bovis BCG 64 kD polypeptide, said sequence having the formula See Patent for Chemical Structure as well as polypeptides derived therefrom, in the amino acid sequence of which sequence 172-179 and/or sequence 189-192 is (are) entirely or partially absent, were found to be useful as immunogens inducing resistance to auto-immune arthritis and similar auto-immune diseases. The invention relates to these polypeptides, to polypeptides showing sequential homology with these polypeptides, and to derivatives and multimers thereof. Also, microorganisms expressing the polypeptides either as such or as part of a fusion protein or as a multimer form part of the invention. Finally, the invention relates to pharmaceutical compositions, diagnostic compositions and test kits comprising a compound according to the invention.
5155098 N-HETEROARYL -PURIN-6AMINES, AND PHARMACEUTICAL COMPOSITIONS AND METHODS EMPLOYING THEM
Structure where R1 is hydrogen, lower alkyl, and arylloweralkyl; R2 and R3 are independently hydrogen, lower alkyl or R2 and R3 taken together are aryl; R4 and R5 are independently hydrogen, lower alkyl, or R4 and R5 taken together are aryl; R6 is hydrogen, lower alkyl, aryl, aryUoweralkyl, See Patent for Chemical Structure where R2, R3, R4 and R5 are as defined above, and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic and anitconvulsant agents.
5155099 ALKYLPHOSPHONOSERINES AND PHARMACEUTICAL COMPOSITIONS USEFUL AS CYTOSTATIC AGENTS Hans Brachwitz, Reinhild Schonfeld, Peter Langen, Friedrich Paltauf, Albin Hermetter, Berlin, Federal Republic Of Germany assigned to Hafslund Nycomed Pharma Aktiengesellschaft Compounds of formula I See Patent for Chemical Structure in which R denotes a straightchain or branched, saturated or unsaturated aliphatic hydrocarbon radical having 6-30 C atoms wich may optionally be substituted by halogen or the radicals OR1, SR1 or NR1R2, where R1 and R2 in each case denote a hydrogen atom or an alkyl or acyl radical having 1-6 C atoms which have excellent virustatic and cytostatic action.
5155102 1-ALKYL-3-(ACYLAMINO)EPSILON-CAPROLACTAMES AS ENHANCERS OF LEARNING AND MEMORY AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
Richard Eft]and, Joseph T Klein, Larr Davis, Gordon E Olson assigned to Hoechst-Roussel Pharmaceuticals Inc
Fabio Giannessi, Orlando Ghirardi, Domenico Misiti, Maria O Tinti, Roberto Cozzolino, Carlo Scolastico, ,nilreB assigned to Sigrna-Tau Industrie Farmaceutiche Riunite S p A
This invention relates to a N-heteroaryl-purin-6amine of the formula See Patent for Chemical
1-alkyl-3-(acylamino)- epsilon-caprolactames of formula (1) See Patent for Chemical Structure (1)