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4954641 Novel antitumor antibiotic substance and a method for production thereof
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PATENT ABSTRACTS
A human monoclonal antibody produced by a self-reproducing carrier cell, the antibody being reactive with PRP capsular polysaccharide. Also disclosed is a process of preparing the antibody from the carrier cell, which is conveniently a hybridoma. Additionally, diagnostic, prophylactic and therapeutic compositions and methods employing the antibody are disclosed. Moreover, a laboratory reagent containing the antibody is described.
4954482 NEW GLYCOPEPTIDE ANTIBIOTIC Hirosh Maeda, Junsuke Tone, John C Ruddock, Kelvin S Holdom, Chita, Japan assigned to Pfizer Inc A new glycopeptide antibiotic UK-68,597 can be prepared by submerged aerobic propagation in aqueous nutrient media of Actinoplanes sp. ATCC 53533. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in poultry, swine and ruminants.
4954617 MONOCLONAL ANTIBODIES TO FC R E C E P T O R S F O R IMMUNOGLOBULIN G ON HUMAN MONONUCLEAR PHAGOCYTES Michael W Fanger, Paul Guyre, Clark L Anderson assigned to Trustees of Dartmouth College Monoclonal antibodies specific for the high affinity (72 K.D.) Fc receptor on human monocytes are diclosed. The monoclonal antibodies do not block normal IgG binding to the receptor.
4954641 NOVEL ANTITUMOR ANTIBIOTIC SUBSTANCE AND A METHOD FOR PRODUCTION THEREOF Yoshikazu Sato, Hiroomi Watabe, Shigetaka Ishii, Tadash Nakazawa, Takashi Shomura, Masaji Sezaki, Shinichi Kondo, Kanagawa, Japan assigned to Meiji Seika Kaisha Ltd
An antibiotic substance represented by formula (I) See Patent for Chemical Structure (I) or a pharmaceutically acceptable salt thereof, which is produced by cultivating a microorganism belonging to the genus Streptomyces and isolating the substance from the cultured cells.
4956180 AB-006 ANTIBIOTICS AND PROCESS FOR THEIR PRODUCTION Giorgio Cassani, Girgi Borgonovi, Dante Cidaria, Daniela Tolentino, Luigi Abis, Gianfranco Guglielmetti, Carlo Garavaglia, Giovanni Confalonieri, Giorgio Pirali, Arluno, Italy assigned to Presidenza Del Consiglio Dei Ministri AB-006 Antibiotics and their AB-006 and AB006b Antibiotic components, obtained by controlled aerobic culture of Streptomyces s.p. NCIB 12425, in an aqueous nutrient culture is disclosed. The AB-006 Antibiotics show biological activity, and in particular fungicidal and insecticidal activity.
4956273 SYNTHETIC PEPTIDES AND METHOD OF USE FOR DIAGNOSIS AND VACCINATION FOR AIDS AND ARC Ronald C Kennedy, Gordon R Dreesman, Myron Essex assigned to Southwest Foundation For Biomedical Research; President and Fellows of Harvard Colle Composition and method for detection of and vaccination against the viral causative agents of AIDS and ARC. The composition is a synthetic peptide, the amino acid sequence of which is sufficiently homologous to the amino acid sequence of the gp 41 and gp 120 subunits of the gp 160 envelope glycoprotein of HTLV-III, LAV or ARC to produce an immunogenic response in a patient and which has a hydrophilic region therein. The composition may be conjugated to an appropriate carrier for use as a vaccine against AIDS and ARC or bound to the ligand of a specific binding pair, contacted with a sample of biological fluid from a patient suspected of having contracted AIDS or ARC and thereafter contacted with the anti-ligand of the specific bi-
PATENT ABSTRACTS
A human monoclonal antibody produced by a self-reproducing carrier cell, the antibody being reactive with PRP capsular polysaccharide. Also disclosed is a process of preparing the antibody from the carrier cell, which is conveniently a hybridoma. Additionally, diagnostic, prophylactic and therapeutic compositions and methods employing the antibody are disclosed. Moreover, a laboratory reagent containing the antibody is described.
4954482 NEW GLYCOPEPTIDE ANTIBIOTIC Hirosh Maeda, Junsuke Tone, John C Ruddock, Kelvin S Holdom, Chita, Japan assigned to Pfizer Inc A new glycopeptide antibiotic UK-68,597 can be prepared by submerged aerobic propagation in aqueous nutrient media of Actinoplanes sp. ATCC 53533. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in poultry, swine and ruminants.
4954617 MONOCLONAL ANTIBODIES TO FC R E C E P T O R S F O R IMMUNOGLOBULIN G ON HUMAN MONONUCLEAR PHAGOCYTES Michael W Fanger, Paul Guyre, Clark L Anderson assigned to Trustees of Dartmouth College Monoclonal antibodies specific for the high affinity (72 K.D.) Fc receptor on human monocytes are diclosed. The monoclonal antibodies do not block normal IgG binding to the receptor.
4954641 NOVEL ANTITUMOR ANTIBIOTIC SUBSTANCE AND A METHOD FOR PRODUCTION THEREOF Yoshikazu Sato, Hiroomi Watabe, Shigetaka Ishii, Tadash Nakazawa, Takashi Shomura, Masaji Sezaki, Shinichi Kondo, Kanagawa, Japan assigned to Meiji Seika Kaisha Ltd
An antibiotic substance represented by formula (I) See Patent for Chemical Structure (I) or a pharmaceutically acceptable salt thereof, which is produced by cultivating a microorganism belonging to the genus Streptomyces and isolating the substance from the cultured cells.
4956180 AB-006 ANTIBIOTICS AND PROCESS FOR THEIR PRODUCTION Giorgio Cassani, Girgi Borgonovi, Dante Cidaria, Daniela Tolentino, Luigi Abis, Gianfranco Guglielmetti, Carlo Garavaglia, Giovanni Confalonieri, Giorgio Pirali, Arluno, Italy assigned to Presidenza Del Consiglio Dei Ministri AB-006 Antibiotics and their AB-006 and AB006b Antibiotic components, obtained by controlled aerobic culture of Streptomyces s.p. NCIB 12425, in an aqueous nutrient culture is disclosed. The AB-006 Antibiotics show biological activity, and in particular fungicidal and insecticidal activity.
4956273 SYNTHETIC PEPTIDES AND METHOD OF USE FOR DIAGNOSIS AND VACCINATION FOR AIDS AND ARC Ronald C Kennedy, Gordon R Dreesman, Myron Essex assigned to Southwest Foundation For Biomedical Research; President and Fellows of Harvard Colle Composition and method for detection of and vaccination against the viral causative agents of AIDS and ARC. The composition is a synthetic peptide, the amino acid sequence of which is sufficiently homologous to the amino acid sequence of the gp 41 and gp 120 subunits of the gp 160 envelope glycoprotein of HTLV-III, LAV or ARC to produce an immunogenic response in a patient and which has a hydrophilic region therein. The composition may be conjugated to an appropriate carrier for use as a vaccine against AIDS and ARC or bound to the ligand of a specific binding pair, contacted with a sample of biological fluid from a patient suspected of having contracted AIDS or ARC and thereafter contacted with the anti-ligand of the specific bi-