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4376778 Antibiotic substances and processes for production thereof
125
PATENT ABSTRACTS
4376822
P R O D U C T I O N OF H U M A N IFNG A M M A (IMMUNE) INTERFERON Irwin A. Braude, assigned to Meloy Laboratories lnc A process is disclosed for producing human interferon with cell cultures of h u m a n peripheral blood leukocytes modulated with Mezerein or 12, 13 phorbol dibutyrate and induced with Staphylococcal aureus enterotoxin B. After cultures are incubated from 3 to 7 days crude interferon on the order of 103 units of interferon/ml, is produced. 4376821
P R O D U C T I O N OF H U M A N IFNG A M M A (IMMUNE) INTERFERON
Antibiotics, designated as SF-2080A subs t a n c e a n d S F - 2 0 8 0 B s u b s t a n c e , are described, and are obtained by cultivating an SF-2080 substance-producing strain belonging to the genus Streptomyces, for e x a m p l e , S t r e p t o m y c e s sp. SF-2080 ( F E R M - P No. 5072, ATCC No. 31673), in a nutrient medium, and recovering the desired substance from the culture. 4376761 H O M O C I T R I C ACID DERIVATIVE FOR PREVENTION OF DENTAL CARIES
OLIGORIBOSIDE
Yoshiro Okami, Kazuhiko Yamada, Masachika Takashio, Tokyo, Japan, assigned to Zaidan Hojin Biseihutsu Kagaku Kenkyu Kai COOH
Irwin A. Braude, assigned to Meloy Laboratories lnc A process is disclosed for producing human immune interferon with cell cultures of human peripheral blood leukocytes modulated with Mezerein or 12, 13 phorbol dibutyrate and induced with the calcium ionophore A-23187. After cultures are incubated for 12 hours to about 7 days, crude interferon on the order of 103 units of interferon/ml, is produced. 4376778 ANTIBIOTIC SUBSTANCES A N D PROCESSES FOR PRODUCTION THEREOF Norio Ezaki, Takashi Shomura, Tomizo Niwa, Michio Kojima, Shigeharu lnouye, Tatsuo lto, Yokohama, Japan, assigned to Meiji Seika Kaisha Ltd
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O HOH2C
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C
COOH
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COOH
HO
OH
Dextransucrase synthesis of dextran from sucrose is inhibited by a novel homocitric acid oligoriboside derivative and its nontoxic salts. The new derivative is obtained by fermentation of certain Streptomyces sp. such as Streptomyces sp. M F 980-CF1 (FERM-P5430; ATCC 31820) and is useful in the prevention of dental caries. 4376166
N O C A R D I A STRAIN Thoma Schupp, Pete Traxler, Jako Nuesch, S w i t z e r l a n d , a s s i g n e d to C i b a - G e i g y Corporation
PATENT ABSTRACTS
4376822
P R O D U C T I O N OF H U M A N IFNG A M M A (IMMUNE) INTERFERON Irwin A. Braude, assigned to Meloy Laboratories lnc A process is disclosed for producing human interferon with cell cultures of h u m a n peripheral blood leukocytes modulated with Mezerein or 12, 13 phorbol dibutyrate and induced with Staphylococcal aureus enterotoxin B. After cultures are incubated from 3 to 7 days crude interferon on the order of 103 units of interferon/ml, is produced. 4376821
P R O D U C T I O N OF H U M A N IFNG A M M A (IMMUNE) INTERFERON
Antibiotics, designated as SF-2080A subs t a n c e a n d S F - 2 0 8 0 B s u b s t a n c e , are described, and are obtained by cultivating an SF-2080 substance-producing strain belonging to the genus Streptomyces, for e x a m p l e , S t r e p t o m y c e s sp. SF-2080 ( F E R M - P No. 5072, ATCC No. 31673), in a nutrient medium, and recovering the desired substance from the culture. 4376761 H O M O C I T R I C ACID DERIVATIVE FOR PREVENTION OF DENTAL CARIES
OLIGORIBOSIDE
Yoshiro Okami, Kazuhiko Yamada, Masachika Takashio, Tokyo, Japan, assigned to Zaidan Hojin Biseihutsu Kagaku Kenkyu Kai COOH
Irwin A. Braude, assigned to Meloy Laboratories lnc A process is disclosed for producing human immune interferon with cell cultures of human peripheral blood leukocytes modulated with Mezerein or 12, 13 phorbol dibutyrate and induced with the calcium ionophore A-23187. After cultures are incubated for 12 hours to about 7 days, crude interferon on the order of 103 units of interferon/ml, is produced. 4376778 ANTIBIOTIC SUBSTANCES A N D PROCESSES FOR PRODUCTION THEREOF Norio Ezaki, Takashi Shomura, Tomizo Niwa, Michio Kojima, Shigeharu lnouye, Tatsuo lto, Yokohama, Japan, assigned to Meiji Seika Kaisha Ltd
it
O HOH2C
0
0
HOH
C
COOH
[
COOH
HO
OH
Dextransucrase synthesis of dextran from sucrose is inhibited by a novel homocitric acid oligoriboside derivative and its nontoxic salts. The new derivative is obtained by fermentation of certain Streptomyces sp. such as Streptomyces sp. M F 980-CF1 (FERM-P5430; ATCC 31820) and is useful in the prevention of dental caries. 4376166
N O C A R D I A STRAIN Thoma Schupp, Pete Traxler, Jako Nuesch, S w i t z e r l a n d , a s s i g n e d to C i b a - G e i g y Corporation