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4956180 AB-006 antibiotics and process for their production
Agriculture and Forestry Biotechnology
4956282
4954482
MAMMALIAN PEPTIDE EXPRESSION IN PLANT CELLS
NEW GLYCOPEPTIDE ANTIBIOTIC
Robert Goodman, Vic C Knauf, Catherine M Houck, Luca Comai assigned to Calgene Inc
Hirosh Maeda, Junsuke Tone, John C Ruddock, Kelvin S Holdom, Chita, Japan assigned to Pfizer Inc
Novel constructs are provided for expression of physiologically active mammalian proteins in plant cells, either in culture or under cultivation. The constructs provide a promoter functional in a plant host, a structural gene coding for mammalian protein and a terminator functional in a plant host. The construct is introduced into a plant cell to become integrated into the plant genome for expression in the plant cells or plants. The plant cells may be harvested and the mammalian protein isolated in physiologically active form.
A new glycopeptide antibiotic UK-68,597 can be prepared by submerged aerobic propagation in aqueous nutrient media of Actinoplanes sp. ATCC 53533. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in poultry, swine and ruminants.
4956180 4956452
AB-006 ANTIBIOTICS AND PROCESS FOR THEIR PRODUCTION
MONOCLONAL ANTIBODY WHICH NEUTRALIZES MULTIPLE STRAINS OF INFECTIOUS BURSAL DISEASE
Giorgio Cassani, Girgi Borgonovi, Dante Cidaria, Daniela Tolentino, Luigi Abis, Gianfranco Guglielmetti, Carlo Garavaglia, Giovanni Confalonieri, Giorgio Pirali, Arluno, Italy assigned to Presidenza Del Consiglio Dei Ministri
VIRUS David Snyder, Warren Marquardt, Sammy Gorham, Dolores Lana assigned to The University of Maryland
AB-006 Antibiotics and their AB-006 and AB006b Antibiotic components, obtained by controlled aerobic culture of Streptomyces s.p. NCIB 12425, in an aqueous nutrient culture is disclosed. The AB-006 Antibiotics show biological activity, and in particular fungicidal and insecticidal activity.
Monoclonal antibodies effective in preventing infectious bursal disease in chickens, by neutralizing one or more virus strains thereof, have been isolated and obtained from deposited hybridomas. Vaccination of an entire poultry population with a vaccine prepared from these 131
4956282
4954482
MAMMALIAN PEPTIDE EXPRESSION IN PLANT CELLS
NEW GLYCOPEPTIDE ANTIBIOTIC
Robert Goodman, Vic C Knauf, Catherine M Houck, Luca Comai assigned to Calgene Inc
Hirosh Maeda, Junsuke Tone, John C Ruddock, Kelvin S Holdom, Chita, Japan assigned to Pfizer Inc
Novel constructs are provided for expression of physiologically active mammalian proteins in plant cells, either in culture or under cultivation. The constructs provide a promoter functional in a plant host, a structural gene coding for mammalian protein and a terminator functional in a plant host. The construct is introduced into a plant cell to become integrated into the plant genome for expression in the plant cells or plants. The plant cells may be harvested and the mammalian protein isolated in physiologically active form.
A new glycopeptide antibiotic UK-68,597 can be prepared by submerged aerobic propagation in aqueous nutrient media of Actinoplanes sp. ATCC 53533. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in poultry, swine and ruminants.
4956180 4956452
AB-006 ANTIBIOTICS AND PROCESS FOR THEIR PRODUCTION
MONOCLONAL ANTIBODY WHICH NEUTRALIZES MULTIPLE STRAINS OF INFECTIOUS BURSAL DISEASE
Giorgio Cassani, Girgi Borgonovi, Dante Cidaria, Daniela Tolentino, Luigi Abis, Gianfranco Guglielmetti, Carlo Garavaglia, Giovanni Confalonieri, Giorgio Pirali, Arluno, Italy assigned to Presidenza Del Consiglio Dei Ministri
VIRUS David Snyder, Warren Marquardt, Sammy Gorham, Dolores Lana assigned to The University of Maryland
AB-006 Antibiotics and their AB-006 and AB006b Antibiotic components, obtained by controlled aerobic culture of Streptomyces s.p. NCIB 12425, in an aqueous nutrient culture is disclosed. The AB-006 Antibiotics show biological activity, and in particular fungicidal and insecticidal activity.
Monoclonal antibodies effective in preventing infectious bursal disease in chickens, by neutralizing one or more virus strains thereof, have been isolated and obtained from deposited hybridomas. Vaccination of an entire poultry population with a vaccine prepared from these 131