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5013550 Antibiotics called chloropolysporins B and C, a process for their preparation, and their therapeutic and veterinary use
514
PATENT ABSTRACTS
one charge more than human insulin at a pH value of 7, with preferred substitutions being made for the glutamic acid residues at A4, A 17, B 13, B21 and/or a basic amino acid residue being substituted at B27. Also contemplated is optional blocking the C-terminal carboxyl group of the B-chain with an amido or ester residue.
5008371 BIOLOGICALLY ACTIVE POLYPEPTIDE AND USE THEREOF Shunji Natori, Ibaragi, Japan assigned to Sanwa Kagaku Kenkyusho Co Ltd A biologically active polypeptide, method of obtaining same and use thereof are disclosed. The polypeptide is obtained through steps of cultivating a cell line established from Sarcophaga peregrina embryo to produce the same in a culture medium, as product of the cell line, isolating and purifying the same. The polypeptide shows an anti-virus activity.
The present invention relates to immunogenic preparations of peptides comprising amino acid sequences corresponding to antigenic determinants of the envelope glycoprotein of HIV, covalently coupled, directly or through a spacer molecule, to carrier molecules suitable for vaccination of mammals.
5013~9 PRODUCTION, ISOLATION, AND IDENTIFICATION OF NOVEL ANTIFUNGAL COMPOUNDS Alan R Putnam, Saroj Mishra, Muraleedharan Nair assigned to Board of Trustees Operating Michigan State University A new species of Micromonospora, in particular Micromonospora spartanea A T C C 53803, is described. The species produces antifungal compounds spartanamicins A and B. Methods for the production, isolation and characterization of the compounds are described. The compounds contain deoxy-L-fucose, as well as another hexose and an amino sugar.
5008374
IL-I ALPHA DERIVATIVES AND DRUGS ~;a~or Nakai, Mayumi Kaneta. Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi lshii, Yasuo Yanagihara, Yoshikatsu Hirai, Tokushima, Japan assigned to Otsuka Pharmaceutical Co Lid An interleukin-I alpha (IL-I alpha) derivative having a modified amino acid sequence of IL-I alpha, a gene coding for said derivative. medicinal composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-I alpha.
5013548 PRODUCTION OF ANTIBODIES TO HIV Barton Haynes. Thomas Palker assigned to Duke University
5013550
ANTIBIOTICS CALLED CHLOROPOLYSPORINS B AND C , A PROCESS FOR THEIR PREPARATION, AND THEIR THERAPEUTIC AND VETERINARY USE Tatsuo Hancishi, Takao Okazaki, Akio Torikata, Mutsuo Nakajima, Tokyo, Japan assigned to Sankyo Company Limited Novel compounds, called chloropolysporins B and C, and salts thereof have antibiotic properties and would appear to be members of the class of glycopeptide antibiotics containing chlorine. They may be produced by cultivating a suitable strain of microorganism of the genus Micropolyspora, especially Micropolyspora sp. SANK 60983 (FERM BP-538). They may be combined with conventional pharmaceutically acceptable carriers or diluents for therapeutic use or incorporated into edible excipients, such as feed or water, fbr use as a growth-promoting agent, especially for farm animals.
PATENT ABSTRACTS
one charge more than human insulin at a pH value of 7, with preferred substitutions being made for the glutamic acid residues at A4, A 17, B 13, B21 and/or a basic amino acid residue being substituted at B27. Also contemplated is optional blocking the C-terminal carboxyl group of the B-chain with an amido or ester residue.
5008371 BIOLOGICALLY ACTIVE POLYPEPTIDE AND USE THEREOF Shunji Natori, Ibaragi, Japan assigned to Sanwa Kagaku Kenkyusho Co Ltd A biologically active polypeptide, method of obtaining same and use thereof are disclosed. The polypeptide is obtained through steps of cultivating a cell line established from Sarcophaga peregrina embryo to produce the same in a culture medium, as product of the cell line, isolating and purifying the same. The polypeptide shows an anti-virus activity.
The present invention relates to immunogenic preparations of peptides comprising amino acid sequences corresponding to antigenic determinants of the envelope glycoprotein of HIV, covalently coupled, directly or through a spacer molecule, to carrier molecules suitable for vaccination of mammals.
5013~9 PRODUCTION, ISOLATION, AND IDENTIFICATION OF NOVEL ANTIFUNGAL COMPOUNDS Alan R Putnam, Saroj Mishra, Muraleedharan Nair assigned to Board of Trustees Operating Michigan State University A new species of Micromonospora, in particular Micromonospora spartanea A T C C 53803, is described. The species produces antifungal compounds spartanamicins A and B. Methods for the production, isolation and characterization of the compounds are described. The compounds contain deoxy-L-fucose, as well as another hexose and an amino sugar.
5008374
IL-I ALPHA DERIVATIVES AND DRUGS ~;a~or Nakai, Mayumi Kaneta. Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi lshii, Yasuo Yanagihara, Yoshikatsu Hirai, Tokushima, Japan assigned to Otsuka Pharmaceutical Co Lid An interleukin-I alpha (IL-I alpha) derivative having a modified amino acid sequence of IL-I alpha, a gene coding for said derivative. medicinal composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-I alpha.
5013548 PRODUCTION OF ANTIBODIES TO HIV Barton Haynes. Thomas Palker assigned to Duke University
5013550
ANTIBIOTICS CALLED CHLOROPOLYSPORINS B AND C , A PROCESS FOR THEIR PREPARATION, AND THEIR THERAPEUTIC AND VETERINARY USE Tatsuo Hancishi, Takao Okazaki, Akio Torikata, Mutsuo Nakajima, Tokyo, Japan assigned to Sankyo Company Limited Novel compounds, called chloropolysporins B and C, and salts thereof have antibiotic properties and would appear to be members of the class of glycopeptide antibiotics containing chlorine. They may be produced by cultivating a suitable strain of microorganism of the genus Micropolyspora, especially Micropolyspora sp. SANK 60983 (FERM BP-538). They may be combined with conventional pharmaceutically acceptable carriers or diluents for therapeutic use or incorporated into edible excipients, such as feed or water, fbr use as a growth-promoting agent, especially for farm animals.