- Email: [email protected]
4994270 A54145 antibiotics and process for their production
323
PATENT ABSTRACTS topical application of antibodies to P. aeruginos under conditions and in an amount sufficient to prevent or treat the infection in a mammal. In one embodiment, the antibodies are administrered in form of an aerosol. A preferred dosage for polyclonal antibody preparations (i.e. ISG or high titer P. aeruginosa ISG) ranges from 2 mg/kg to 100 mg/kg body weight of the mammal. A preferred monoclonal antibody dosage ranges from 0.02 to 1.0 mg/kg of body weight.
4994270 A54145 ANTIBIOTICS AND PROCESS FOR THEIR PRODUCTION LaVerne D Boeck, David S Fukuda, Jon S Mynderse, Marvin M Hoehn, Ralph E Kastner, Harold Papiska assigned to Eli Lilly and Company New peptide antibiotic A54145, individual A54145 components A, AI, B, BI, C, D, E and F and their pharmaceutically acceptable salts, are useful antibacterial agents which also improve growth performance in animals, especially poultry. Biologically pure cultures of the A54145-producing Streptomyces fradiae cultures N R R L 18158, N R R L 18159 and N R R L 18160 cultures and methods of making antibiotic A54145 using those cultures are also provided.
Compounds and their use for lowering intraocular pressure are disclosed herein.
4994374 DIAGNOSTIC METHOD OF CIRRHOSIS AND HEPATIC CANCER Atsush Nishikawa, Naoyuk Taniguchi, Isamu Takagahara, Osaka, Japan assigned to Oriental Yeast Co Ltd This invention relates to a method of diagnosing cancerous diseases, which comprises measuring the amount of UDP-N-acetylglucosamine :glycoprotein N-acetylglucosaminyl -transferase in body fluid and evaluating the increase in its amount for the diagnosis of hepatic diseases. AFP, CEA and gamma-glutamyltranspeptidase have hitherto been used as tumor markers for the diagnosis of hepatic cancer. But these conventional tumor markers show a positivity rate of about 60%, making early diagnosis almost impossible. The method of this invention employs UDP-N-acetylglucosamine: glycoprotein Nacetylglucosaminyltransferase as tumor marker, whereby early diagnosis of hepatic cancer can be made almost completely.
4994271 BMY-40800 ANTITUMOR ANTIBIOTICS Kin S L a m , Jacquelin Mattei, John E Leet, James A Matson, Koj Tomita, Murray A Kaplan assigned to Bristol-Myers Company A new antitumor antibiotic designated BMY40800 is produced by fermentation of Streptomyces hygroscopicus ATCC 53653. The new compound inhibits the growth of tumors in experimental animals.
4994274 INTRAOCULAR PRESSURE REDUCING ll,15-DIACYL PROSTAGLANDINS AND METHOD OF USING Ming F Chan, David Woodward assigned to A1lergan Inc
4994555 P R O C E S S F O R R E C O V E R Y OF GLYCOPEPTIDIC ANTIBIOTICS Giambattist Panzone, Anaclet Gianantonio, Cornaredo, Italy assigned to Gruppo Lepetit S p A This invention concerns the recovery of glycopeptidic antibiotics from aqueous solutions resulting from fermentation broths or process streams. Examples of glycopeptidicantibiotics to which the process of this invention may be applied are the following: vancomycin, actaplanin, ristocetin, avoparcin, actinoidin, LLAM-374, A 477, OA 7653, A 35512 B, A 515668, AAD 216, A 41030, A 47934, A-40926 (European Pat. Appln. No. 85112406.5), the individual factors, derivatives and pseudoaglycones and aglycones thereof, teicoplanin and teicoplanin-like compounds.
PATENT ABSTRACTS topical application of antibodies to P. aeruginos under conditions and in an amount sufficient to prevent or treat the infection in a mammal. In one embodiment, the antibodies are administrered in form of an aerosol. A preferred dosage for polyclonal antibody preparations (i.e. ISG or high titer P. aeruginosa ISG) ranges from 2 mg/kg to 100 mg/kg body weight of the mammal. A preferred monoclonal antibody dosage ranges from 0.02 to 1.0 mg/kg of body weight.
4994270 A54145 ANTIBIOTICS AND PROCESS FOR THEIR PRODUCTION LaVerne D Boeck, David S Fukuda, Jon S Mynderse, Marvin M Hoehn, Ralph E Kastner, Harold Papiska assigned to Eli Lilly and Company New peptide antibiotic A54145, individual A54145 components A, AI, B, BI, C, D, E and F and their pharmaceutically acceptable salts, are useful antibacterial agents which also improve growth performance in animals, especially poultry. Biologically pure cultures of the A54145-producing Streptomyces fradiae cultures N R R L 18158, N R R L 18159 and N R R L 18160 cultures and methods of making antibiotic A54145 using those cultures are also provided.
Compounds and their use for lowering intraocular pressure are disclosed herein.
4994374 DIAGNOSTIC METHOD OF CIRRHOSIS AND HEPATIC CANCER Atsush Nishikawa, Naoyuk Taniguchi, Isamu Takagahara, Osaka, Japan assigned to Oriental Yeast Co Ltd This invention relates to a method of diagnosing cancerous diseases, which comprises measuring the amount of UDP-N-acetylglucosamine :glycoprotein N-acetylglucosaminyl -transferase in body fluid and evaluating the increase in its amount for the diagnosis of hepatic diseases. AFP, CEA and gamma-glutamyltranspeptidase have hitherto been used as tumor markers for the diagnosis of hepatic cancer. But these conventional tumor markers show a positivity rate of about 60%, making early diagnosis almost impossible. The method of this invention employs UDP-N-acetylglucosamine: glycoprotein Nacetylglucosaminyltransferase as tumor marker, whereby early diagnosis of hepatic cancer can be made almost completely.
4994271 BMY-40800 ANTITUMOR ANTIBIOTICS Kin S L a m , Jacquelin Mattei, John E Leet, James A Matson, Koj Tomita, Murray A Kaplan assigned to Bristol-Myers Company A new antitumor antibiotic designated BMY40800 is produced by fermentation of Streptomyces hygroscopicus ATCC 53653. The new compound inhibits the growth of tumors in experimental animals.
4994274 INTRAOCULAR PRESSURE REDUCING ll,15-DIACYL PROSTAGLANDINS AND METHOD OF USING Ming F Chan, David Woodward assigned to A1lergan Inc
4994555 P R O C E S S F O R R E C O V E R Y OF GLYCOPEPTIDIC ANTIBIOTICS Giambattist Panzone, Anaclet Gianantonio, Cornaredo, Italy assigned to Gruppo Lepetit S p A This invention concerns the recovery of glycopeptidic antibiotics from aqueous solutions resulting from fermentation broths or process streams. Examples of glycopeptidicantibiotics to which the process of this invention may be applied are the following: vancomycin, actaplanin, ristocetin, avoparcin, actinoidin, LLAM-374, A 477, OA 7653, A 35512 B, A 515668, AAD 216, A 41030, A 47934, A-40926 (European Pat. Appln. No. 85112406.5), the individual factors, derivatives and pseudoaglycones and aglycones thereof, teicoplanin and teicoplanin-like compounds.