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4980457 Cytotoxic conjugates which can be used in therapy and process for their preparation
New Patents tivity than intact IFN- gamma and a method of producing the same. The polypeptides not only possess a remarkable antiviral activity, antitumor activity, immunopotentiatingactivity but also is highly stable, therefore, it can be used advantageously as pharmaceuticals.
4980457 CYTOTOXIC CONJUGATES WHICH CAN BE USED IN THERAPY AND PROCESS FOR THEIR PREPARATION Fran Jansen, Pierre Gros, Castries, France assigned to Sanofi Immunotoxins formed by the covalent coupling of, on the one hand, the A chain of ricin, as such or correctly modified, with, on the other hand, an antibody or a fragment of an antibody, used in its natural form or correctly modified, which possesses the capacity to selectively recognize an antigen carried by the intended target cells. The coupling is effected either via a disulfide bond or via a thioether bond, with the limitation that, when the coupling is effected via a disulfide and one of the sulfur atoms is that belonging to the A chain of ricin, the other sulfur is bonded to the antibody by a spacing structure which is itself bonded to a group of the protein other than an amine group.
4981684 FORMATION OF ADJUVANT COMPLEXES Neill M MacKenzie, Angela M O'Sullivan, St Albans, United Kingdom assigned to Coopers Animal Health Limited Iscom adjuvant matrices, comprising a sterol, a glycoside, a solubilized water-insoluble antigen and, optionally, a phospholipid, may be formed without removing the solubilizing agent used for the antigen. The glycoside is preferably Quil A and the sterol is preferably cholesterol.
4981685 BACTERIAL EXTRACT VACCINES FOR VETERINARY APPLICATION Mark C Healey assigned to Utah State University Foundation
vii
The present invention relates to novel bacterial extract vaccines for use in veterinary medicine and to novel methods for preparing such vaccines. The bacteria responsible for a particular bacterially induced disease is contacted with a detergent so as to extract from the bacterial cells the antigens responsible for eliciting a protective immune response against the disease. Subsequently, the resultant antigen extract is dialyzed to remove the detergent. The antigen extract is then preferably combined with a vaccine enhancing adjuvant to provide an effective and inexpensive vaccine for veterinary application. The present invention provides for the preparation of a variety of vaccines which can be used to immunize animals against a variety of bacterially induced diseases.
4981782 SYNTHETIC PEPTIDES FOR DIAGNOSIS AND PREVENTION OF INFLUENZA VIRUS INFECTION AND THEIR USE Amrit K Judd, Doris Bucher, Steven W Popple assigned to SRI International Synthetic polypeptides having influenza virus antigenic properties are disclosed. These polypeptides correspond substantially to particular regions in the matrix protein of influenza virus. Salts, derivatives, and conjugates of these polypeptides are disclosed as well as methods for using these materials for diagnostic and medical/veterinary purposes.
4981792 IMMUNOSUPPRESSANT COMPOUND Edward Inamine, Byron H Arison, Shieh-Shung T Chen, Linda Wicker assigned to Merck & Co Inc Described is a process for producing a new immunosuppressant, demethomycin (L682,993) a C-31 demethylated analog of L679,934 under novel fermentation conditions utilizing the microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in prevent human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
4980457 CYTOTOXIC CONJUGATES WHICH CAN BE USED IN THERAPY AND PROCESS FOR THEIR PREPARATION Fran Jansen, Pierre Gros, Castries, France assigned to Sanofi Immunotoxins formed by the covalent coupling of, on the one hand, the A chain of ricin, as such or correctly modified, with, on the other hand, an antibody or a fragment of an antibody, used in its natural form or correctly modified, which possesses the capacity to selectively recognize an antigen carried by the intended target cells. The coupling is effected either via a disulfide bond or via a thioether bond, with the limitation that, when the coupling is effected via a disulfide and one of the sulfur atoms is that belonging to the A chain of ricin, the other sulfur is bonded to the antibody by a spacing structure which is itself bonded to a group of the protein other than an amine group.
4981684 FORMATION OF ADJUVANT COMPLEXES Neill M MacKenzie, Angela M O'Sullivan, St Albans, United Kingdom assigned to Coopers Animal Health Limited Iscom adjuvant matrices, comprising a sterol, a glycoside, a solubilized water-insoluble antigen and, optionally, a phospholipid, may be formed without removing the solubilizing agent used for the antigen. The glycoside is preferably Quil A and the sterol is preferably cholesterol.
4981685 BACTERIAL EXTRACT VACCINES FOR VETERINARY APPLICATION Mark C Healey assigned to Utah State University Foundation
vii
The present invention relates to novel bacterial extract vaccines for use in veterinary medicine and to novel methods for preparing such vaccines. The bacteria responsible for a particular bacterially induced disease is contacted with a detergent so as to extract from the bacterial cells the antigens responsible for eliciting a protective immune response against the disease. Subsequently, the resultant antigen extract is dialyzed to remove the detergent. The antigen extract is then preferably combined with a vaccine enhancing adjuvant to provide an effective and inexpensive vaccine for veterinary application. The present invention provides for the preparation of a variety of vaccines which can be used to immunize animals against a variety of bacterially induced diseases.
4981782 SYNTHETIC PEPTIDES FOR DIAGNOSIS AND PREVENTION OF INFLUENZA VIRUS INFECTION AND THEIR USE Amrit K Judd, Doris Bucher, Steven W Popple assigned to SRI International Synthetic polypeptides having influenza virus antigenic properties are disclosed. These polypeptides correspond substantially to particular regions in the matrix protein of influenza virus. Salts, derivatives, and conjugates of these polypeptides are disclosed as well as methods for using these materials for diagnostic and medical/veterinary purposes.
4981792 IMMUNOSUPPRESSANT COMPOUND Edward Inamine, Byron H Arison, Shieh-Shung T Chen, Linda Wicker assigned to Merck & Co Inc Described is a process for producing a new immunosuppressant, demethomycin (L682,993) a C-31 demethylated analog of L679,934 under novel fermentation conditions utilizing the microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in prevent human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.