5116863 Dibenz(b,e)oxepin derivative and pharmaceutical compositions thereof

N e w Patents

5116855 RHODANINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS HRoshi Inoue, Hlrokl Kato, Norlyosh Sueda, Yoshiyukl Tahara, Nobuturo Kmosh~ta, Saltama, Japan assigned to N~sshin Flour Mflhng Co Ltd

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ployed m the treatment and control of allergic condltaons such as allergic asthma and also employed m the treatment of inflammation

5116877 PHARMACEUTICAL USE FOR CINNAMAMIDE DERIVATIVES Hlronaka Alhara, Mlchio Kurachi, Kazuyukl Tommawa, Katamoto, Japan assigned to Tmsho Pharmaceutical Co Ltd

Dmclosed is a rhodanme denvauve of formula (I) A rhodamne denvaUve of formula (I) See Patent for Chemtcal Structure (I) whereto R1 is hdyrogen, C 1-C8 alkyl, carboxyl(C 1-C4)alkyl or (C1-C4)alkoxycarbonyl (C1-C4) alkyl, R2 is CH2-CH2-R3, CH double bondCHmR3 (m is 0 or 1), See Patent f or Chemtcal Structure (R is C1-C3 alkyl) or -CH2nCONHR4 (n is 0 or 1-4), R3 is a thienyl or furyl group which may be substltuted by C1-C3 alkyl or halo gen, a pyrrolyl group which may be subsututed by carboxy(C 1C3)alkyl on the n ltrogen atom, or a phenyl group which may be substituted by one or more substl tuents selected from the group consisting of C1-C3 alkyl, C1-C3 alkoxy, hydrox yl, halogen, tnfluoromethyl, carboxyl, (C1C3)alkoxycarbonyl, cyano, carboxy( C1C3)alkoxy, (C1-C6)alkoxycarbonyl (C1C3)alkoxy, benzyloxycarbonyl (C1-C3)alkoxy, plpendmylcarbonyl (C1-C3)alkoxy, 2Htetrazolyl, 2H-tetrazolyl-(C 1-C4)alko xy, carboxy(C2-C4) alkenyl, (C 1C3)alkoxycarbonyl (C2-C4)alkenyl, carboxy(CI-C3) alkyl and (C1C3)alkoxycarbonyl (C1-C3)alkyl, and R4 is a phenyl group which m a y be subsUtuted by one or more of the same subst~tuents as defined above, or a pharmaceutically acceptable salt thereof The denvatlves are of an mhibR ory actlwty against aldose reductase and useful for the prevention or treatment ofcomphcat~ons ofdmbetes

Dlhydrocaffelc acad denvatwes are here dinclosed which are apphcable as medicines having excellent absorbency m the case of oral adnumstratmn and good concentration retenuon m blood. The disclosed compounds have the funcUon to reduce the production and secreuon of a nerve growth factor (NGF) m the brain Ussue, and therefore they are effectwe as medicines for the progression mhibmon and therapy of regressive dmorders of the central nervous system

5116863

5118500

DIBENZ(B,E)OXEPIN DERIVATIVE AND PHARMACEUTICAL COMPOSITIONS THEREOF

PHARMACEUTICAL CONTAINING TNF INHIBITOR

Etsu Oshima, Toshiaka Kumazawa, Shizuo Otala, Hlroyukl Obase, Kenjl Ohmon, Hldee Ishil, Harutuko Manabe, Tadafurm Tamura, Katsmchi Shuto, Shizuoka, Japan assigned to Kyowa Hakko Kogyo Co Ltd Novel dlbenz(b,e)oxepm

denvatwes are em-

A cmnamam~de denvatwe represented by the formula See Patent for Chemical Structure wherem X is a halogen atom is useful as a muscle relaxant

5116979 DIHYDROCAFFEIC ACID DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME Nobuyuka Fukazawa, Hajlme hzuka, Osamu Yano, Yukao Mlyama, Mobara, Japan assigned to Mitsm Toatsu Chemicals Incorporated

Hem Hanel, Elmar Schnnner, Oberursel, Federal Repubhc Of Germany assigned to Hoechst AktaengeseUschaft PharmaceuUcals which contain a substance releasing tumor necrosls factor CrNF) are better tolerated and can be given in higher doses when they contain a T N F inhibltor,espccmUy a xanthine derivative