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Effect of Coffee Consumption on Cholangiocarcinoma Risk and Survival
Table 2 Odds ratio estimates for the association between coffee consumption and CCA risk for each subtype
*Adjusted for age, gender, diabetes, inflammatory bowel disease, smoking
Mo1417
AASLD Abstracts
ETHNIC DIFFERENCES IN OVERALL SURVIVAL OF PATIENTS WITH CIRRHOSIS: RESULTS OF A COHORT OF 2939 UNITED STATES PATIENTS WITH LONG-TERM FOLLOW-UP Changqing Zhao, Pauline Nguyen, Joseph Hoang, Sam Trinh, Cho Clare, Lee Ann Yasukawa, Susan C. Weber, Mindie H. Nguyen Background/aims: Cirrhosis is a serious complication of many chronic liver diseases and the natural history and long-term survival among patients with different ethnicities may differ. Our goal is to characterize and examine disease progression and survival outcomes in cirrhotic patients with different ethnicity. Methods: We performed a retrospective cohort study of consecutive adult patients who presented with cirrhosis (diagnosed by histology or non-invasive radiological or clinical criteria) at a U.S. university center from 2005-2010.A total of 4348 patients were identified by ICD 9 query and confirmed to have cirrhosis by chart review. Of those, 439 patients had liver transplantation prior to index date (first visit date with cirrhosis)were excluded. Another970patients of ethnicity other than White, Asian, Hispanic, and Black were excluded, leaving 2939 patients for study inclusion. Results: Mean age was 57±12, and 61% were male. The distribution of White, Asian, Hispanic and Black ethnicities were 53%(n=1554),19%(n=560),24%(n=703),and 4%(n=122), respectively. HCV were the primary etiology in White (49%), Asian(39%), Hispanic(53%), and Black(66%).HBV, cryptogenic and non-alcoholic steatohepatitis/fatty liver disease (NASHNAFLD), dual infection of HBV and HCV, alcoholic (ALD)and other non-viral were 1.4%,7.3%,0.4%,23.3%,18.5% in White, 25.2%,5.2%,1.3%,12.9%,16.3%in Asian; 0.6%,8.8%,0.0%,24.6%,12.7% in Hispanic; and 0.8%,1.6%,0.0%,12.3%, 18.9% in Black; respectively. Cumulative 5-year hepatic decompensation incidence was highest in Hispanic (49%), followed by Black (41%), then White (37%) and lowest in Asian (28%)(p<0.0001).However, in the 1931 patients without HCC at baseline, cumulative 5year HCC incidence was highest in Asian (19%), followed by Hispanic (15%),then White(11%)and lowest in Black (9%) (p<0.05)(Figure 1). Despite this, Asian has the highest estimated 5and 10-year survival rates (56% and 48%), followed by Black (51% and 38%) and white(51% and 35%), and lowest in Hispanic (40% and 27%), respectively (p<0.0001)(Figure 2). Conclusions: In this large ethnically diverse U.S. cohort of patients with cirrhosis, hepatic decompensation incidence was highest in Hispanic, and Black and HCC incidence highest in Asian. However, Hispanic patients with cirrhosis had the lowest overall survival. Further effort is needed to examine these outcome disparities in patients of different ethnicities.
Clinical factor for PVTT response
Mo1416 EFFECT OF COFFEE CONSUMPTION ON CHOLANGIOCARCINOMA RISK AND SURVIVAL Veeravich Jaruvongvanich, Ju Dong Yang, Thoetchai Peeraphatdit, Lewis R. Roberts Background/Objective Epidemiologic studies suggest that coffee can prevent and decrease risk of death in several types of cancers. However, the effect of coffee consumption on cholangiocarcinoma (CCA) remains poorly understood due to its low incidence. The aim of this study was therefore to assess the influence of coffee consumption on risk of CCA and risk of death among CCA patients. Methods A hospital-based case-control study was conducted at a tertiary care medical center from 2000 through 2014. We identified 230 CCA cases (98 intrahepatic [ICC], 132 extrahepatic [ECC]) who completed a questionnaire regarding coffee intake. Controls were matched two to one with cases by age, sex, race and residence (n=460). Adjusted odds ratios (AOR) and 95% confidence intervals (CI) were estimated between coffee consumption as a dichotomous variable, as well as amount of consumption, and the risk of CCA using logistic regression. A Cox proportional hazard model was used to calculate the hazard ratio (HR) for CCA mortality Results The AOR for CCA comparing coffee drinkers to non-drinkers was 0.82 (95%CI 0.52-1.28, P = 0.37) (Table 1). In the analysis of risk of different CCA subtypes, AORs were 0.72 (95%CI 0.401.31, P = 0.28) for ICC and 0.78 (95%CI 0.43-1.43, P = 0.43) for ECC (Table 2). No association was noted between coffee consumption and risk of death among patients with CCA (HR = 1.12, 95%CI 0.77-1.62, P = 0.56), ICC (HR=1.10, 95%CI 0.61-1.97, P = 0.76), and ECC (HR=1.15, 95%CI 0.71-1.87, P = 0.56). All analyses remained insignificant when classified according to amount of consumption or gender. Conclusions Coffee intake was neither associated with risk of CCA development nor with risk of death in patients with CCA. However, we observed trends toward a protective effect of coffee on the risk of CCA. Further prospective studies with larger sample sizes are needed. Table 1 Odds ratio estimates for the association between coffee consumption and CCA risk
*Adjusted for age, gender, race, primary sclerosing cholangitis, cirrhosis, Hepatitis C, inflammatory bowel disease, diabetes, obesity, nonalcoholic fatty liver disease, smoking
AASLD Abstracts
S-1176
*Adjusted for age, gender, diabetes, inflammatory bowel disease, smoking
Mo1417
AASLD Abstracts
ETHNIC DIFFERENCES IN OVERALL SURVIVAL OF PATIENTS WITH CIRRHOSIS: RESULTS OF A COHORT OF 2939 UNITED STATES PATIENTS WITH LONG-TERM FOLLOW-UP Changqing Zhao, Pauline Nguyen, Joseph Hoang, Sam Trinh, Cho Clare, Lee Ann Yasukawa, Susan C. Weber, Mindie H. Nguyen Background/aims: Cirrhosis is a serious complication of many chronic liver diseases and the natural history and long-term survival among patients with different ethnicities may differ. Our goal is to characterize and examine disease progression and survival outcomes in cirrhotic patients with different ethnicity. Methods: We performed a retrospective cohort study of consecutive adult patients who presented with cirrhosis (diagnosed by histology or non-invasive radiological or clinical criteria) at a U.S. university center from 2005-2010.A total of 4348 patients were identified by ICD 9 query and confirmed to have cirrhosis by chart review. Of those, 439 patients had liver transplantation prior to index date (first visit date with cirrhosis)were excluded. Another970patients of ethnicity other than White, Asian, Hispanic, and Black were excluded, leaving 2939 patients for study inclusion. Results: Mean age was 57±12, and 61% were male. The distribution of White, Asian, Hispanic and Black ethnicities were 53%(n=1554),19%(n=560),24%(n=703),and 4%(n=122), respectively. HCV were the primary etiology in White (49%), Asian(39%), Hispanic(53%), and Black(66%).HBV, cryptogenic and non-alcoholic steatohepatitis/fatty liver disease (NASHNAFLD), dual infection of HBV and HCV, alcoholic (ALD)and other non-viral were 1.4%,7.3%,0.4%,23.3%,18.5% in White, 25.2%,5.2%,1.3%,12.9%,16.3%in Asian; 0.6%,8.8%,0.0%,24.6%,12.7% in Hispanic; and 0.8%,1.6%,0.0%,12.3%, 18.9% in Black; respectively. Cumulative 5-year hepatic decompensation incidence was highest in Hispanic (49%), followed by Black (41%), then White (37%) and lowest in Asian (28%)(p<0.0001).However, in the 1931 patients without HCC at baseline, cumulative 5year HCC incidence was highest in Asian (19%), followed by Hispanic (15%),then White(11%)and lowest in Black (9%) (p<0.05)(Figure 1). Despite this, Asian has the highest estimated 5and 10-year survival rates (56% and 48%), followed by Black (51% and 38%) and white(51% and 35%), and lowest in Hispanic (40% and 27%), respectively (p<0.0001)(Figure 2). Conclusions: In this large ethnically diverse U.S. cohort of patients with cirrhosis, hepatic decompensation incidence was highest in Hispanic, and Black and HCC incidence highest in Asian. However, Hispanic patients with cirrhosis had the lowest overall survival. Further effort is needed to examine these outcome disparities in patients of different ethnicities.
Clinical factor for PVTT response
Mo1416 EFFECT OF COFFEE CONSUMPTION ON CHOLANGIOCARCINOMA RISK AND SURVIVAL Veeravich Jaruvongvanich, Ju Dong Yang, Thoetchai Peeraphatdit, Lewis R. Roberts Background/Objective Epidemiologic studies suggest that coffee can prevent and decrease risk of death in several types of cancers. However, the effect of coffee consumption on cholangiocarcinoma (CCA) remains poorly understood due to its low incidence. The aim of this study was therefore to assess the influence of coffee consumption on risk of CCA and risk of death among CCA patients. Methods A hospital-based case-control study was conducted at a tertiary care medical center from 2000 through 2014. We identified 230 CCA cases (98 intrahepatic [ICC], 132 extrahepatic [ECC]) who completed a questionnaire regarding coffee intake. Controls were matched two to one with cases by age, sex, race and residence (n=460). Adjusted odds ratios (AOR) and 95% confidence intervals (CI) were estimated between coffee consumption as a dichotomous variable, as well as amount of consumption, and the risk of CCA using logistic regression. A Cox proportional hazard model was used to calculate the hazard ratio (HR) for CCA mortality Results The AOR for CCA comparing coffee drinkers to non-drinkers was 0.82 (95%CI 0.52-1.28, P = 0.37) (Table 1). In the analysis of risk of different CCA subtypes, AORs were 0.72 (95%CI 0.401.31, P = 0.28) for ICC and 0.78 (95%CI 0.43-1.43, P = 0.43) for ECC (Table 2). No association was noted between coffee consumption and risk of death among patients with CCA (HR = 1.12, 95%CI 0.77-1.62, P = 0.56), ICC (HR=1.10, 95%CI 0.61-1.97, P = 0.76), and ECC (HR=1.15, 95%CI 0.71-1.87, P = 0.56). All analyses remained insignificant when classified according to amount of consumption or gender. Conclusions Coffee intake was neither associated with risk of CCA development nor with risk of death in patients with CCA. However, we observed trends toward a protective effect of coffee on the risk of CCA. Further prospective studies with larger sample sizes are needed. Table 1 Odds ratio estimates for the association between coffee consumption and CCA risk
*Adjusted for age, gender, race, primary sclerosing cholangitis, cirrhosis, Hepatitis C, inflammatory bowel disease, diabetes, obesity, nonalcoholic fatty liver disease, smoking
AASLD Abstracts
S-1176