- Email: [email protected]
Handbook of laboratory animal management and welfare
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Acknowledgements The authors would llke to thank Annmarae Surprenant for her useful adwe and suggestions
C K IS supported by grants from the Medical Research Council. Wellcome Trust and Sconlsh Hospital Endowments Research Trust
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32 Illes, P. and Norenberg, W. (1992) Trends Pharmacol. Sci. 14,5%54 33 Boyer, J. L., Downes, C. P. and Harden, T. K. (1989) J Biol. Chem. 264, 884-890 34 Burnstock, G. et al. (1994) Drug Dev. Res. 31,206-209 35 Fiitz, T. M., Li, Q., Boyer, J. L., Nichols, R. A. and Harden, T. K. (1994) Mol. Pharmacol. 468-14 36 Choo, L. K. (1980) J. Pharm. Pharmacol. 33,24&250 37 Bo, X., Fischer, B., Maillard, M., Jacobson, K. A. and Burnstock, G. (1994) Br. J. Pharmacol. 112,1151-1159 38 Biiltmann, R. and Starke, K. (1994) Naunyn-Schmied. Arch. Pharmacol. 349,74-80 39 Michel, A. D., Trezise, D. J., Grahames, C. B. A., Khakh, B. S. and Humphrey, P. P. A. (1994) Br. J. Pharmacol. 113,58P 4o Thomas, S. A., Zawisa, M. J., Lin, X. and Hume, R. I. (1991) Br. J. Pharmacol. 103,196>1969 41 Scamps, F. and Vassort, G. (1994) Br. J. Pharmacol. 113,982-986 M. (1983) Eur. J. Pharmacol. 87, 42 Chapal, J. and Loubatieres-Mariani, 42ti30
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0
0
K
Handbook of Laboratory Animal Management and Welfare edited by S. Wolfensohn and M. Lloyd, Oxford University Press, 1994. EM.50 (xi + 304 pages) ISBN 0 19 854832 X
The regulations controlling the use of animals in research in Great Britain are sufficiently comprehensive and complex to make it worth having a published guide on your bookshelf. Indeed, there are several short, useful and well-written books which fill this niche. This book by Sarah Wolfensohn and Maggie Lloyd is aiming well beyond these other publications. In addition to explaining the system of regulation set up by the Animals (Scientific Procedures) Act 1986, this book covers the details of laboratory animal husbandry, biological data and handling. It also has useful sections on recognition of pain and distress, anaesthesia, analgesia and surgical techniques, all in under 300 pages. For many years, the classic textbook of laboratory animal science was the Universities Federation for Animal Welfare (UFAW) Handbook
TiPS - May
1995
(Vol. 16)
Chemical name FPL67156: eneATP
6-N,N-diethyl-D-P,?-dibromomethyl-
I
s
Healthy body, healthy mind
1 7 4
43 Kennedy, C., Delbro, D. and Burnstock, G. (1985) Eur. J, Pharmacol. 107,161-168 44 Reilly, W. M. and Bumstock, G. (1987) Eur. J. Pharmacol. 138, 319-325 45 Houston, D. A., Burnstock, G. and Vanhoutte, P. M. (1987) J. Phrmacol. Exp. Ther. 241,501506 46 Venkova, K., Milne, A. and Krier, J. (1994) Br. J. Pharmacol. 112, 1237-1243 47 Boyer, J. L., Lazarowski, E. R., Chen, X. and Harden, T. K. (1993) J. Pharmncol. Exp. Ther. 267,1140-1146
on the Care and Management of Laboratory Animals. However, since the last edition of the UFAW Handbook was published in 1986, there have been significant developments in so many areas of laboratory animal science that it now takes a whole shelf to accommodate the publications reflecting the state of the art. What role does that leave for the Wolfensohn and Lloyd book which is something like a modernized and streamlined UFAW Handbook? The function that I can see for this book is to provide a source of easy reference for the project licence applicant and holder. High standards of laboratory animal science and welfare are expected by the Home Office and project licence applications are scrutinized in detail by the Inspectorate. If a researcher wants his or her application to be approved first time by the Home Office, he or she would be well advised to have consulted this book when drafting it. Concepts of best practice in laboratory animal science are evolving rapidly and the regulations and policies governing animal procedures are amended regularly. I hope that the authors intend to revise this book every two or three years because it is sufficiently important to merit it. The value of this volume for researchers goes far beyond the project licence application. The public debate about animal experimentation will not simply go away. The best
arguments we have in that debate are that animal experimentation is necessary and that it is conducted carefully and humanely. In many ways it is the latter point which is the most important. In my experience, researchers in academia and industry are concerned that they should work to high standards of animal welfare. This book is a valuable tool for researchers to help them achieve those high standards. Mark Matfield Research Defence Society, 58 Great Marlborough Street, London, UK WlV 1DD.
Drugs on the run Pharmacodynamics Drug Development
and
edited by Neal R. Cutler, John R. Sramek and Prem K. Narong, Wiley, 1994. E65.00 (xv + 491 pages) ISBN 0 471950 521
Clinical pharmacology can be divided into two operational areas pharmacodynamics (what a drug does to the body) and pharmacokinetics (what the body does to a drug). The measured response to a drug, be it efficacious or toxic, may be related to its absorption, distribution,
Acknowledgements The authors would llke to thank Annmarae Surprenant for her useful adwe and suggestions
C K IS supported by grants from the Medical Research Council. Wellcome Trust and Sconlsh Hospital Endowments Research Trust
E
V
E
I
W
32 Illes, P. and Norenberg, W. (1992) Trends Pharmacol. Sci. 14,5%54 33 Boyer, J. L., Downes, C. P. and Harden, T. K. (1989) J Biol. Chem. 264, 884-890 34 Burnstock, G. et al. (1994) Drug Dev. Res. 31,206-209 35 Fiitz, T. M., Li, Q., Boyer, J. L., Nichols, R. A. and Harden, T. K. (1994) Mol. Pharmacol. 468-14 36 Choo, L. K. (1980) J. Pharm. Pharmacol. 33,24&250 37 Bo, X., Fischer, B., Maillard, M., Jacobson, K. A. and Burnstock, G. (1994) Br. J. Pharmacol. 112,1151-1159 38 Biiltmann, R. and Starke, K. (1994) Naunyn-Schmied. Arch. Pharmacol. 349,74-80 39 Michel, A. D., Trezise, D. J., Grahames, C. B. A., Khakh, B. S. and Humphrey, P. P. A. (1994) Br. J. Pharmacol. 113,58P 4o Thomas, S. A., Zawisa, M. J., Lin, X. and Hume, R. I. (1991) Br. J. Pharmacol. 103,196>1969 41 Scamps, F. and Vassort, G. (1994) Br. J. Pharmacol. 113,982-986 M. (1983) Eur. J. Pharmacol. 87, 42 Chapal, J. and Loubatieres-Mariani, 42ti30
I3
0
0
K
Handbook of Laboratory Animal Management and Welfare edited by S. Wolfensohn and M. Lloyd, Oxford University Press, 1994. EM.50 (xi + 304 pages) ISBN 0 19 854832 X
The regulations controlling the use of animals in research in Great Britain are sufficiently comprehensive and complex to make it worth having a published guide on your bookshelf. Indeed, there are several short, useful and well-written books which fill this niche. This book by Sarah Wolfensohn and Maggie Lloyd is aiming well beyond these other publications. In addition to explaining the system of regulation set up by the Animals (Scientific Procedures) Act 1986, this book covers the details of laboratory animal husbandry, biological data and handling. It also has useful sections on recognition of pain and distress, anaesthesia, analgesia and surgical techniques, all in under 300 pages. For many years, the classic textbook of laboratory animal science was the Universities Federation for Animal Welfare (UFAW) Handbook
TiPS - May
1995
(Vol. 16)
Chemical name FPL67156: eneATP
6-N,N-diethyl-D-P,?-dibromomethyl-
I
s
Healthy body, healthy mind
1 7 4
43 Kennedy, C., Delbro, D. and Burnstock, G. (1985) Eur. J, Pharmacol. 107,161-168 44 Reilly, W. M. and Bumstock, G. (1987) Eur. J. Pharmacol. 138, 319-325 45 Houston, D. A., Burnstock, G. and Vanhoutte, P. M. (1987) J. Phrmacol. Exp. Ther. 241,501506 46 Venkova, K., Milne, A. and Krier, J. (1994) Br. J. Pharmacol. 112, 1237-1243 47 Boyer, J. L., Lazarowski, E. R., Chen, X. and Harden, T. K. (1993) J. Pharmncol. Exp. Ther. 267,1140-1146
on the Care and Management of Laboratory Animals. However, since the last edition of the UFAW Handbook was published in 1986, there have been significant developments in so many areas of laboratory animal science that it now takes a whole shelf to accommodate the publications reflecting the state of the art. What role does that leave for the Wolfensohn and Lloyd book which is something like a modernized and streamlined UFAW Handbook? The function that I can see for this book is to provide a source of easy reference for the project licence applicant and holder. High standards of laboratory animal science and welfare are expected by the Home Office and project licence applications are scrutinized in detail by the Inspectorate. If a researcher wants his or her application to be approved first time by the Home Office, he or she would be well advised to have consulted this book when drafting it. Concepts of best practice in laboratory animal science are evolving rapidly and the regulations and policies governing animal procedures are amended regularly. I hope that the authors intend to revise this book every two or three years because it is sufficiently important to merit it. The value of this volume for researchers goes far beyond the project licence application. The public debate about animal experimentation will not simply go away. The best
arguments we have in that debate are that animal experimentation is necessary and that it is conducted carefully and humanely. In many ways it is the latter point which is the most important. In my experience, researchers in academia and industry are concerned that they should work to high standards of animal welfare. This book is a valuable tool for researchers to help them achieve those high standards. Mark Matfield Research Defence Society, 58 Great Marlborough Street, London, UK WlV 1DD.
Drugs on the run Pharmacodynamics Drug Development
and
edited by Neal R. Cutler, John R. Sramek and Prem K. Narong, Wiley, 1994. E65.00 (xv + 491 pages) ISBN 0 471950 521
Clinical pharmacology can be divided into two operational areas pharmacodynamics (what a drug does to the body) and pharmacokinetics (what the body does to a drug). The measured response to a drug, be it efficacious or toxic, may be related to its absorption, distribution,