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Histaminase in the treatment of allergy
529
ABSTRBC’I’S
patient to discomfort varies greatly, and one must be on guard for an orereuaggeration of the symptoms. The use of intranasal measures introduces another difficulty Intranasal therapy may act to increase in evaluating the north of any therapy. discomfort rather than to ease it. Eyermann believes that a given therapy shoultl be applied to the same patient ant1 evaluated in relation to the factors known to influence the symptomatology over a period of five years before conclucling as to its worthiness as a therapeutic agent.
Potassium J.
A.
Chloride 31. A.
114:
in Allergic 3850,
Disorders.
Harsch,
G. I’.,
and
Donovan,
I’.
R.:
1040.
Employing mainly the closes and technique recommendetl by Rloom, the authors treatecl forty allergic patients (in San Diego) with potassium chloride. Of the series studied, twenty-six had hay fever, seven had asthma, two had migraine, two gastrointestinal allergy, fire urticaria, and one exfoliative dermatitis. Of the entire group, only one patient (with rasomotor rhinitis) obtained relief, and in that patient the Determinations of the serum relief persisted after the therapy was discontinued. sodium were matle in eighteen of these patients and of the serum potassium in fifteen lIefore and after medication. No significant changes were fouml.
Potassium 1627,
Salts in Hay Fever.
Afiller,
H.,
and
Piness,
G.:
J.
A.
l\f.
A.
114:
1640.
The authors treated forty hay fever patients with about 15 to 40 grains of potassium chloride daily. Only two of these patients obtainetl relief, but these two patients also were benefited by placebo solutions of sodium bicarbonate ant1 sodium chloride. Kller and Pines3 also mention that in serrral instances of urticaria, migraine, and asthma no benefit was obtained from potassium chlori(le. Contrary to claims of others, the asthma WHS not aggravatetl.
Histaminase 114:
li42,
in the Treatment
of Allergy.
Miller,
H.,
and
Piness,
G.:
J. A.
l\f.
A.
1940.
The authors treated forty-two allergic patients, twenty-nine of whom hacl urticaria, with an average dose of from 60 to 75 units of histaminase tlaily. Some of the patients were treated over periods ranging from one to eight nlonths. None of the cases of allergic tlernratitis, asthma, or hay fever was benrfite~l. Sewn of the patients with urticaria were relieve~l, although in none of these cl0 the authors feel that relief couhl be attribute,d with certainty to the enzyme.
Antibody Formation in a Lesion Produced by Tubercle Paraffin Oil. Excision of the Antigenic Depot. Westwater, 38:
267,
Bacilli ,T. 0.:
Suspended
in
.T. Immunol.
1940.
The author reports studies undertaken to determine whether an organism stimulates antibody production after excision of the antigenic depot. For this study, the investigator used the tubercle bacillus, an organism which causes antibodies to al’pear slowly in the serum (usually after two or three weeks). In the abdominal skin of rabbits, depots containing 0.2, 0.1 or 0.05 mg. of dried tubercle bacilli in 0.2 ml. of paraffin oil were matle. At intervals varying from one
ABSTRBC’I’S
patient to discomfort varies greatly, and one must be on guard for an orereuaggeration of the symptoms. The use of intranasal measures introduces another difficulty Intranasal therapy may act to increase in evaluating the north of any therapy. discomfort rather than to ease it. Eyermann believes that a given therapy shoultl be applied to the same patient ant1 evaluated in relation to the factors known to influence the symptomatology over a period of five years before conclucling as to its worthiness as a therapeutic agent.
Potassium J.
A.
Chloride 31. A.
114:
in Allergic 3850,
Disorders.
Harsch,
G. I’.,
and
Donovan,
I’.
R.:
1040.
Employing mainly the closes and technique recommendetl by Rloom, the authors treatecl forty allergic patients (in San Diego) with potassium chloride. Of the series studied, twenty-six had hay fever, seven had asthma, two had migraine, two gastrointestinal allergy, fire urticaria, and one exfoliative dermatitis. Of the entire group, only one patient (with rasomotor rhinitis) obtained relief, and in that patient the Determinations of the serum relief persisted after the therapy was discontinued. sodium were matle in eighteen of these patients and of the serum potassium in fifteen lIefore and after medication. No significant changes were fouml.
Potassium 1627,
Salts in Hay Fever.
Afiller,
H.,
and
Piness,
G.:
J.
A.
l\f.
A.
114:
1640.
The authors treated forty hay fever patients with about 15 to 40 grains of potassium chloride daily. Only two of these patients obtainetl relief, but these two patients also were benefited by placebo solutions of sodium bicarbonate ant1 sodium chloride. Kller and Pines3 also mention that in serrral instances of urticaria, migraine, and asthma no benefit was obtained from potassium chlori(le. Contrary to claims of others, the asthma WHS not aggravatetl.
Histaminase 114:
li42,
in the Treatment
of Allergy.
Miller,
H.,
and
Piness,
G.:
J. A.
l\f.
A.
1940.
The authors treated forty-two allergic patients, twenty-nine of whom hacl urticaria, with an average dose of from 60 to 75 units of histaminase tlaily. Some of the patients were treated over periods ranging from one to eight nlonths. None of the cases of allergic tlernratitis, asthma, or hay fever was benrfite~l. Sewn of the patients with urticaria were relieve~l, although in none of these cl0 the authors feel that relief couhl be attribute,d with certainty to the enzyme.
Antibody Formation in a Lesion Produced by Tubercle Paraffin Oil. Excision of the Antigenic Depot. Westwater, 38:
267,
Bacilli ,T. 0.:
Suspended
in
.T. Immunol.
1940.
The author reports studies undertaken to determine whether an organism stimulates antibody production after excision of the antigenic depot. For this study, the investigator used the tubercle bacillus, an organism which causes antibodies to al’pear slowly in the serum (usually after two or three weeks). In the abdominal skin of rabbits, depots containing 0.2, 0.1 or 0.05 mg. of dried tubercle bacilli in 0.2 ml. of paraffin oil were matle. At intervals varying from one