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Histaminase in the treatment of serum sickness
618
‘1’111: JOl~l
Anaphylaxis Med.
in the Pregnant
40:
24X,
The author wsceptibility influence
Rat.
OF
AI.I.E:KGY
l(:ltnoff’,
0. 11.:
I’wc.
SW. E~per.
Kol.
6-
l!)X).
re\iebv.; the lilernture on of animals to anaphylactic
of pregnancy
111:. role
shock in the rat.
on xnaphylaxis
of
the
and
endocrine
reports
his
glands studies
in
the
on
the
The rat was chosen Ipecause of its natural refractoriness to anaph~-laxis, rendering any increased susceptil)ility to shock more readily apparent. Within twentyfour to thirty-six hours after the time of impregnation, 1 C.C. of normal horse wwm was in,jwtrtl intravenously am1 repeated three ant1 six tlaps later. Eleven da>-s after the last irl,jcction, the eighteenth day of pregnancy, a shocking dose of 7 c.c. was injected intravenously, and the animal observ-ed for shock symptoms. These results were compared with those obtained in 17 normal nonpregnant female control rats. sensitized and shocked in the identical manner. No significant dif?‘erence between the frequency pregnant and the nonpregnant animals was observed. tion and shock had no demonstral)le effect on the The writer concludes that in the rat the endocrine ha\-e no lwaring on snscrptil)ility to anaphylaxin.
Histaminase 0. I:.:
of
anaphylactic The experience numller of rats rearrangements
in the Treatment of Serum Sickness. hr. A. 112: 2,9X, 1939.
E’oshay,
I,.,
shock in the of sensitizxin each litter. of pregnancy
and
Hagehusch,
.T. A.
Hypothesizing that the major phenomena of serum sickness are due to a release of histamine, or a histamine-like substance, the authors studied the effects of the administration of the enzyme, histaminase, on the control or prevention of the local and general symptoms of serum sickness. The oral or intramuwular :tdmi~listration of adequate amounts of histaminase Illought marked relief to 20 of 22 unselected patients IT-ith serum disease. Sixteen of 18 patients, treated on either the first or second day of illness, obtained marked relief in from eighteen to thirty-six hours. The writers re~omnicnded the use of one :~mlwule. containing one histamine detoxicating unit, gi\.en irltr:n,lllscul;lrl!morning and night for five injections. In severe cases this dose should be increased for the first, day and possibly also for the second da>-. In conjunction with the intramuscular injections they give 4 or 5 tablets, each containing five histamine detoxicating units, before each meal on the first day, followed 1)~ :i or 4 talllets thrice daily- for the next two days. So evidence ot’ unpleasant 01’ untoward efYects resulted from this therapy.
Passive Sensitization Animals. Sherman, 447,
of Human W.
n.,
Skin
Stull,
by Serum
A.,
and
of Experimentally
Hampton,
R. E’.:
Sensitized
J. Immunol.
36:
19:jn.
Because of the contradictor?sensitization of human skin authors present their findings
results 1)~ serum in similar
reported 1,~ various of experimentall>studies.
Guinea pigs given one intra-al)domirlal injection of pollen (ragweed, timoth>-, orchard grass, June grass) protein nitrogen units l,er culjic centimeter developed centage of instances as shown 1)~ the Dale technique. were used for passive skin sensitization of nonatopica Hera from 6 guinea pig serum was used as a control. None of the transferred sensitivity to human skin.
workers sensitized
ou the passive animals, the
2 C.C. of alum-precipitated extracts containing 2,500 sensitivity in a large perThe sera of these animals Normal human beings. of the 23 injected animals sera of animals bled less
‘1’111: JOl~l
Anaphylaxis Med.
in the Pregnant
40:
24X,
The author wsceptibility influence
Rat.
OF
AI.I.E:KGY
l(:ltnoff’,
0. 11.:
I’wc.
SW. E~per.
Kol.
6-
l!)X).
re\iebv.; the lilernture on of animals to anaphylactic
of pregnancy
111:. role
shock in the rat.
on xnaphylaxis
of
the
and
endocrine
reports
his
glands studies
in
the
on
the
The rat was chosen Ipecause of its natural refractoriness to anaph~-laxis, rendering any increased susceptil)ility to shock more readily apparent. Within twentyfour to thirty-six hours after the time of impregnation, 1 C.C. of normal horse wwm was in,jwtrtl intravenously am1 repeated three ant1 six tlaps later. Eleven da>-s after the last irl,jcction, the eighteenth day of pregnancy, a shocking dose of 7 c.c. was injected intravenously, and the animal observ-ed for shock symptoms. These results were compared with those obtained in 17 normal nonpregnant female control rats. sensitized and shocked in the identical manner. No significant dif?‘erence between the frequency pregnant and the nonpregnant animals was observed. tion and shock had no demonstral)le effect on the The writer concludes that in the rat the endocrine ha\-e no lwaring on snscrptil)ility to anaphylaxin.
Histaminase 0. I:.:
of
anaphylactic The experience numller of rats rearrangements
in the Treatment of Serum Sickness. hr. A. 112: 2,9X, 1939.
E’oshay,
I,.,
shock in the of sensitizxin each litter. of pregnancy
and
Hagehusch,
.T. A.
Hypothesizing that the major phenomena of serum sickness are due to a release of histamine, or a histamine-like substance, the authors studied the effects of the administration of the enzyme, histaminase, on the control or prevention of the local and general symptoms of serum sickness. The oral or intramuwular :tdmi~listration of adequate amounts of histaminase Illought marked relief to 20 of 22 unselected patients IT-ith serum disease. Sixteen of 18 patients, treated on either the first or second day of illness, obtained marked relief in from eighteen to thirty-six hours. The writers re~omnicnded the use of one :~mlwule. containing one histamine detoxicating unit, gi\.en irltr:n,lllscul;lrl!morning and night for five injections. In severe cases this dose should be increased for the first, day and possibly also for the second da>-. In conjunction with the intramuscular injections they give 4 or 5 tablets, each containing five histamine detoxicating units, before each meal on the first day, followed 1)~ :i or 4 talllets thrice daily- for the next two days. So evidence ot’ unpleasant 01’ untoward efYects resulted from this therapy.
Passive Sensitization Animals. Sherman, 447,
of Human W.
n.,
Skin
Stull,
by Serum
A.,
and
of Experimentally
Hampton,
R. E’.:
Sensitized
J. Immunol.
36:
19:jn.
Because of the contradictor?sensitization of human skin authors present their findings
results 1)~ serum in similar
reported 1,~ various of experimentall>studies.
Guinea pigs given one intra-al)domirlal injection of pollen (ragweed, timoth>-, orchard grass, June grass) protein nitrogen units l,er culjic centimeter developed centage of instances as shown 1)~ the Dale technique. were used for passive skin sensitization of nonatopica Hera from 6 guinea pig serum was used as a control. None of the transferred sensitivity to human skin.
workers sensitized
ou the passive animals, the
2 C.C. of alum-precipitated extracts containing 2,500 sensitivity in a large perThe sera of these animals Normal human beings. of the 23 injected animals sera of animals bled less