- Email: [email protected]
Late-Breaking Abstract Sessions
AB390 Abstracts
J ALLERGY CLIN IMMUNOL FEBRUARY 2017
SATURDAY
Late-Breaking Abstract Sessions Late Breaking Oral Abstract Session Basic Science
Clinical/Translational Science 3611 Sunday, March 5th, 2017, 2:00 PM - 3:15 PM L6
2611 Saturday, March 4th, 2017, 2:00 PM - 3:15 PM L1
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Airway Exosomes from Asthmatics Modulate Differential T Helper Responses Jessy Deshane, PhD, Kenneth Hough, BS, Landon Wilson, BS, Marion Spell, BS, Jennifer L Trevor, MD, Diptiman Chanda, PhD, Jose Rodriguez Dager, BS, Yong Wang, PhD, Stephen Barnes, PhD, Veena Antony, MD, Chad Steele, PhD, Mark Dransfield, MD, Steven Duncan, MD, Jeevan Prasain, PhD and Victor Thannickal, MD, University of Alabama at Birmingham, Birmingham, AL Prostaglindin I2 Orchestrates Regulatory and Effector T CellMediated Autoimmunity Melissa H. Bloodworth1, Kelli L. Boyd1, Lisa M. Rogers2, David M. Aronoff2 and Stokes Peebles Jr, MD, FAAAAI3, 1 Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, 2Division of Infectious Diseases, Vanderbilt University, Nashville, TN, 3Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, TN Immune Differences in Asthmatic Children Using Mass Cytometry Tara Paglino1, Mary Prunicki1, Xiaoying Zhou1 and Kari C Nadeau, MD, PhD, FAAAAI2, 1Stanford, Stanford, 2Stanford University, Stanford, CA Maternal DNA Methylation in Second Half of Pregnancy in Th1, Th2, Th17 and Treg Pathway Genes Differs with Birth-Order Orpita Nilormee, BDS, MPH1, Gabrielle A. Lockett, PhD2, Sabrina Iqbal, BDS, MPH3, John W. Holloway, PhD2, Syed H. Arshad, DM, FRCP4, Hongmei Zhang, PhD1 and Wilfried Karmaus5, 1The University of Memphis, Memphis, TN, 2 University of Southampton, Southampton, United Kingdom, 3 The University Of Memphis, Memphis, TN, 4University of Southampton, Isle of Wright, United Kingdom, 5Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, The University of Memphis, Memphis, TN Immunogenicity of 50-Valent Rhinovirus Vaccine Sujin Lee, PhD1,2, Minh Trang Nguyen1, Michael G Currier1, Joe B Jenkins, PhD3, Elizabeth A Strobert3, Adriana E Kajon, PhD4, Ranjna Madan-Lala, PhD5, Yury A. Bochkov, PhD6, James E. Gern, MD, FAAAAI7, Krishnendu Roy, PhD5, Xiaoyan Lu8, Dean D Erdman, PhD8, Paul Spearman, MD3 and Martin L. Moore, PhD1,2, 1Emory University, Atlanta, GA, 2Children’s Healthcare of Atlanta, Atlanta, GA, 3Emory University, Atlanta, 4Lovelace Respiratory Research Institute, Albuquerque, 5Georgia Tech, Atlanta, 6University of Wisconsin-Madison, Madison, WI, 7University of Wisconsin School of Medicine and Public Health, Madison, WI, 8CDC, Atlanta
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TPSAB1 Genotype and Effects of Pro-Tryptases on Human Mast Cell-Associated Disorders Jonathan Lyons, MD1, Jack Chovanec, BS1, Yihui Liu, PhD1, Quang T Le, PhD2, Yun Bai, MS3, Amy P Hsu, BA4, Hirsh D. Komarow, MD3, Melody C. Carter, MD, FAAAAI3, Lawrence B. Schwartz, MD, PhD2, Dean D. Metcalfe, MD3, and Joshua D. Milner, MD1, 1NIH/NIAID/LAD/GPAS, Bethesda, 2Virginia Commonwealth University, Richmond, VA, 3NIH/ 4 NIH/NIAID/LAD/LCID, NIAID/LAD/MCBS, Bethesda, Bethesda Efficacy and Safety of Long-Term Epicutaneous Immunotherapy (EPIT) Treatment of Peanut Allergy with ViaskinÒ peanut: Results of the Two-Year Extension of the Vipes Phase IIb Clinical Trial Wayne G. Shreffler, MD, PhD, FAAAAI, Masschusetts General Hospital, Boston, MA; Division of Allergy and Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, Kari C Nadeau, MD, PhD, FAAAAI, Stanford University, Stanford, CA, Stephanie A. Leonard, MD, Division of Pediatric Allergy & Immunology, Rady Children’s Hospital, San Diego, CA; Rady Children’s Hospital/ UCSD, San Diego, CA, Gordon L. Sussman, MD, FAAAAI, University of Toronto, Toronto, ON, Canada and Hugh A. Sampson, MD FAAAAI, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY Evaluation of Risk Factors for Infections and Systemic Reactions (SRs) Associated with Subcutaneous and Sublingual Allergen Immunotherapy (SCIT and SLIT): AAAAI/ACAAI National Surveillance Study 2008-2015 Tolly Epstein, MD, MS, FAAAAI1, Gary M. Liss, MD, MS FRCPC2, Karen J. Murphy-Berendts, BS, RRT, CCRC3 and David I. Bernstein, MD, FAAAAI3,4, 1University of Cincinnati Division of Immunology, Allergy, & Rheumatology, Cincinnati, OH, 2 University of Toronto, Toronto, ON, Canada, 3Bernstein Clinical Research Center, LLC, Cincinnati, OH, 4University of Cincinnati College of Medicine, Cincinnati, OH The Impact of an Integrated Antibiotic Allergy Testing Program on Antimicrobial Stewardship: A Multicentre Evaluation Jason A. Trubiano, MBBS, FRACP1,2, Karen Thursky3, Andrew J Stewardson1, Karen Urbancic1, Leon J Worth3, Michael Sutherland1, Monica A Slavin3, M Lindsay Grayson1 and Elizabeth J. Phillips, MD4,5, 1Austin Health, Melbourne, Australia, 2 University of Melbourne, Melbourne, Australia, 3Peter MacCallum Cancer Centre, Melbourne, Australia, 4Institute for Immunology & Infectious Diseases, Murdoch University, Murdoch, Australia, 5Vanderbilt University School of Medicine, Division of Infectious Diseases, Department of Medicine, Nashville, TN Randomized Placebo-Controlled Multicenter Clinical Trial of Wheat Oral Immunotherapy Anna H. Nowak-Wegrzyn, MD, PhD, FAAAAI1, Robert A. Wood, MD, FAAAAI2, Kari C Nadeau, MD, PhD, FAAAAI3,
Abstracts AB391
J ALLERGY CLIN IMMUNOL VOLUME 139, NUMBER 2
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Late Breaking Poster Session 4213 Monday, March 6th, 2017, 9:45 AM - 10:45 PM L11
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Potency, Selectivity, and Exposure Evaluation of ATN-249, a New Oral Kallikrein Inhibitor for Hereditary Angioedema Ira Kalfus, MD, Andrew McDonald, PhD and Shawn Qian, PhD, Attune Pharmaceuticals, LLC, New York City, NY Influence of Conformational and Linear IgE Epitopes on Ara h 2-Specific IgE-Binding Angelika Tscheppe, MSc1, Dieter Palmberger, PhD2, Christian Radauer, PhD1, Merima Bublin, PhD1, Christine Hafner, MD3, Wolfgang Hemmer, PhD4, Vanessa Mayr, MSc1, Chiara Palladino, MSc1, Barbara Gepp, PhD1, Nina Lengger, BMA1, Reingard Grabherr, PhD2 and Heimo Breiteneder, PhD1, 1Medical University of Vienna, Vienna, Austria, 2University of Natural Resources and Life Sciences, Vienna, Austria, 3Karl Landsteiner University of Health Science, St.Poelten, Austria, 4Floridsdorf Allergy Center, Vienna, Austria Differential Role of Foxp3+ Regulatory T Cells during Allergen Sensitization and Challenge Booki Min, DVM, PhD, Lerner Research Institute/NB30, Cleveland, OH Roflumilast Ameliorates Ovalbumin-Induced Neutrophilic Airway Inflammation in Mice: Role of CD4+ CD25+ FOXP3+ Regulatory T-Cells Mohamed G. Elsakkar Sr1, Olla A. Sharaki2, Dina M. Abdallah2, Dalia K. Mostafa2 and Fadia T. Shekondali3, 1Alexandria University, Alexandria, Egypt, Alexandria, Egypt, 2Faculty of Medicine, Alexandria University, Alexandria, Egypt, Alexandria, Egypt, 3Faculty of Medicine, EL-Zawia University, Libya, ELZawia, Libya Covalent Heterbivalent Inhibitors for Food Allergies Peter E. Deak, University of Notre Dame, Notre Dame, IN and Basar Bilgicer, PhD, University of Notre Dame, Notre Dame The National Burden of Asthma in Children in the U.S.: Results from a Nationally Representative Study Patrick W. Sullivan, PhD1, Vahram Ghushchyan, PhD2, Prakash Navaratnam, PhD3, Howard Friedman, PhD3, Abhishek Kavati, PhD4, Pin Xiang, PhD5, Benjamin Ortiz, MD6, and Bobby Q. Lanier, MD, FAAAAI7, 1Regis University, Denver, CO, 2University of Colorado Denver, Denver, 3DataMed Solutions, New York, NY, 4 Novartis Pharmaceuticals Inc., East Hanover, NJ, 5Novartis Pharmaceuticals, Inc., East Hanover, NJ, 6Novartis Pharmaceuticals Corporation, East Hanover, NJ, 7North TX Institute for Clinical Trials, Fort Worth, TX Mepolizumab Significantly Improves Health Status and Asthma Control in Severe Eosinophilic Asthma: The Musca Study - a Phase IIIb Randomized, Placebo-Controlled Trial Geoffrey L Chupp, MD1, Eric S Bradford2, Frank C Albers2, Daniel J Bratton3, Jie Wang-Jairaj, PhD3, Linda M Nelsen4, Jennifer L Trevor, MD5, Antoine Magnan, MD6 and Anneke ten Brinke, MD7, 1Yale School of Medicine, New Haven, CT,
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GSK, Research Triangle Park, NC, 3GSK, Stockley Park, United Kingdom, 4GSK, Collegeville, PA, 5University of Alabama at Birmingham, Birmingham, AL, 6Universite de Nantes, Nantes, France, 7Medical Centre Leeuwarden, Leeuwarden, Netherlands Mepolizumab Improves Lung Function and Exacerbation Rates in Severe Eosinophilic Asthma: The Musca Study - a Phase IIIb Randomized, Placebo-Controlled Tria Jennifer L Trevor, MD1, Eric S Bradford2, Frank C Albers2, Daniel J Bratton3, Jie Wang-Jairaj, PhD3, Linda M Nelsen4, Geoffrey L Chupp, MD5, Antoine Magnan, MD6, and Anneke ten Brinke, MD7, 1University of Alabama at Birmingham, Birmingham, AL, 2GSK, Research Triangle Park, NC, 3GSK, Stockley Park, United Kingdom, 4GSK, Collegeville, PA, 5Yale School of Medicine, New Haven, CT, 6Universite de Nantes, Nantes, France, 7Medical Centre Leeuwarden, Leeuwarden, Netherlands Development of Specific Electronic Phenotypes for Severe Cutaneous Adverse Drug Reactions Facilitates Genetic Discovery Sarah Garon, MD1, Lincoln Shade, BSc1, Michael I. Derrick, MD1, Adrian Bejan, PhD1, and Elizabeth J. Phillips, MD1,2, 1Vanderbilt University Medical Center, Nashville, TN, 2Institute for Immunology & Infectious Diseases, Murdoch University, Murdoch, Australia Outcome of 583 Entry Double-Blind Placebo-Controlled Peanut Challenges during Screening for the Palisade Phase 3 Oral Immunotherapy Trial Brian P. Vickery, MD, FAAAAI1,2, Kirsten Beyer, MD3, A. Wesley Burks, MD, FAAAAI4, Thomas B. Casale, MD, FAAAAI5, Jonathan O. Hourihane, MD, FAAAAI6, Stacie M. Jones7, Amr Radwan, MBBChir, FFPM8, Andrea Vereda, MD, PhD8, and Daniel C. Adelman, MD, FAAAAI8,9, 1University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Aimmune Therapeutics, Brisbane, CA, 3Charite Universitatsmedizin Berlin, Berlin, Germany, 4University of North Carolina, Chapel Hill, NC, 5 University of South Florida, Tampa, FL, 6University College Cork, Cork, Ireland, 7Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, AR, 8Aimmune Therapeutics Inc, Brisbane, CA, 9 University of California, San Francisco, Redwood City, CA Long-Term Safety and Efficacy of Open-Label Dupilumab in Patients with Moderate-to-Severe Atopic Dermatitis Mette Deleuran1, Diamant Thac¸i2, Lisa A. Beck, MD, FAAAAI3, Seth Forman4, Weily Soong, MD, FAAAAI5, Iftikhar Hussain6, Robert Bissonnette7, Jean-David Bouaziz8, Joel Gelfand9, Lawrence Sher10, Zhen Chen11, Bolanle Akinlade11, Abhijit Gadkari11, Laurent Eckert12, Neil MH Graham11, Gianluca Pirozzi13, and Marius Ardeleanu11, 1Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark, 2Comprehensive Center for Inflammation Medicine, University Hospital Schleswig-Holstein, Lubeck, Germany, 3Depts of Dermatology and Microbiology, University of Rochester Medical Center, Rochester, NY, 4Forman Dermatology and Skin Cancer Institute, Tampa, FL, 5Alabama Allergy & Asthma Center, Birmingham, AL, 6Vital Prospects Clinical Research Institute, PC, Tulsa, OK, 7Innovaderm Research, Montreal, QC, Canada, 8Dermatology Department, Saint-Louis Hospital, Paris, France, 9Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, 10Peninsula Research Associates, Rolling Hills Estates, CA, 11Regeneron Pharmaceuticals, Tarrytown, NY, 12Sanofi, Chilly-Mazarin, France, 13Sanofi, Bridgewater, NJ DNA Methylation Status Predicts Response to Inhaled Corticosteroids in Pediatric Asthmatics Alberta L. Wang, MD1,2, Weiliang Qiu, PhD2, and Kelan G. Tantisira, MD, MPH2, 1Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 2 Channing Division of Network Medicine, Department of
SUNDAY
Jacqueline A. Pongracic, MD, FAAAAI4, Alice Henning5, Kirsten Beyer, MD6, Robert W. Lindblad, MD5, and Hugh A. Sampson, MD, FAAAAI7,8, 1Icahn School of Medicine at Mount Sinai, New York, NY, 2Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, 3Stanford University, Stanford, CA, 4Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 5The EMMES Corporation, Rockville, MD, 6Charite - Universitaetsmedizin Berlin, Berlin, Germany, 7 Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 8DBV Technologies, New York, NY
AB392 Abstracts
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MONDAY
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Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston The Effects of Inhaled Fluticasone Propionate on Seasonal Exacerbations in Preschool-Aged Children at High Risk for Asthma William C. Anderson, MD1, John T. Brinton, PhD2, Lance Ford, BS2, Shelby Lineberry2, Casey Sakamoto2, Marie Tomisato2, Robert S. Zeiger, MD, PhD, FAAAAI3,4, Robert F. Lemanske, MD, FAAAAI5, Fernando D. Martinez, MD6, Theresa W. Guilbert, MD, MS7, Leonard B. Bacharier, MD8, David M. Mauger, PhD9, and Stanley J. Szefler, MD, FAAAAI1, 1Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, 2 Colorado Summer Institute in Biostatistics, Department of Biostatistics and Informatics, University of Colorado School of Public Health, Aurora, CO, 3University of California, La Jolla, CA, 4 Kaiser Permanente Southern California, San Diego, CA, 5Departments of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 6Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, 7Department of Pediatrics, Asthma Center, Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 8Department of Pediatrics, Washington University School of Medicine and St. Louis Children’s Hospital, St. Louis, MO, 9Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA Pilot Study of Asthmawin Mobile Iphone App in the Management of Asthma Elena R. Reece, MD, Howard University, Washington, DC, Autumn F. Burnette, MD, Howard University, Arlington, VA and Cassia J. Lewis-Land, MA, Johns Hopkins University, Baltimore, MD A New Liquid 10% Intravenous Immunoglobulin (IVIG) Administered with 15-Minute Titration Periods Allows Shorter Infusion Durations and Tolerability Similar to a 5% Formulation Mark R. Stein, MD, FAAAAI1, Kelly Farnan, RMA, CCRC1, Danielle Eufrasio, RMA, CCRC1, and Miranda Norton, PhD2, 1 Allergy Associates of the Palm Beaches, North Palm Beach, FL, 2Bio Products Laboratory, Elstree, United Kingdom Drug Allergy Training Opportunities in the United States: A Survey of Allergy and Immunology Program Directors Michael I. Derrick, MD1, Elizabeth McKinnon, PhD2 and Elizabeth J. Phillips, MD1,2, 1Vanderbilt University Medical Center, Nashville, TN, 2Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia Genotype-Phenotype Correlations in Patients with Hereditary Angioedema Luana S.M. Maia, MSc1, Mariana Paes Leme Ferriani, MD, PhD1, Fernanda Leonel Nunes, MD1, Maria Fernanda Ferraro, MD1, Marina Mendonca Dias, Chem1, Faradiba Sarquis Serpa, MD, MSc2, Antonio Abilio Motta3, Solange Rodrigues Valle, MD, PhD4, Wilson Araujo Silva-Jr, PhD1, Davi Casale Aragon, MSc1, Willy Sarti, MD, PhD1, Luisa Karla P. Arruda, MD PhD FAAAAI1 and Adriana S. Moreno, PhD1, 1Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil, 2School of Medicine of Santa Casa de Misericordia of Vitoria, Vitoria, Brazil, 3Clinical Immunology and Allergy Division of Sao Paulo University, Sao Paulo, Brazil, 4Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Activation of the Complement, Coagulation and Fibrinolysis Pathways after Nasal Allergen Challenge Ryan S Thwaites, PhD1, Natasha C. Gunawardana, MD1, Verena L Broich, MSc1, Elizabeth H Mann, PhD2, Gaynor A Campbell, PhD1, Tanushree Tunstall, MSc1, Sarah Lindsley1, Catherine M. Hawrylowicz, PhD2, Peter J.M. Openshaw, MBBS, PhD, FRCP3, and Trevor T. Hansel, MD PhD1, 1National Heart and
J ALLERGY CLIN IMMUNOL FEBRUARY 2017
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Lung Institute, London, United Kingdom, 2MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, London, United Kingdom, 3Imperial Col Sch Med, St. Mary’s Hospital, London, United Kingdom KIF3A genetic Variation Is Associated with a Pediatric Asthma Phenotype Characterized By Past or Current Eczema Independent of Allergic Rhinitis Elisabet Johansson, PhD1, Jocelyn M. Biagini Myers, PhD1, Lisa J. Martin, PhD1, Hua He, MS1, Valentina Pilipenko, PhD1, Tesfaye B Mersha, PhD1, Matthew T. Weirauch, PhD1, Nathan Salomonis, PhD1, Patrick H. Ryan, PhD1, Grace K. LeMasters, PhD2, David I. Bernstein, MD FAAAAI2, James E. Lockey, MD MS FAAAAI2, and Gurjit (Neeru) K Khurana Hershey, MD, PhD1, 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2University of Cincinnati College of Medicine, Cincinnati, OH Efficacy of Zileuton in Patients with Asthma and History of Aspirin Sensitivity: A Retrospective Analysis of Data from Two Phase 3 Studies Tanya M. Laidlaw, MD, FAAAAI, Brigham and Women’s Hospital, Division of Rheumatology, Immunology, and Allergy, Boston, MA, Daniel J. Fuentes, PharmD, Chiesi USA, Cary, NC and Yi Wang, PhD, FMD K&L, Fort Washington, PA Understanding Anaphylaxis in Camps: A Study Measuring Demographics, Knowledge, and Incidence of Allergic Reactions Margaret Redmond, MD1, Michael Pistiner, MD, MMSc2, Rebecca Scherzer, MD, FAAAAI1, Frank J. Twarog, MD, PhD, FAAAAI3, David R. Stukus, MD, FAAAAI1, and John Lee, MD3, 1Nationwide Children’s Hospital, Columbus, OH, 2Harvard Vanguard Medical Associates, Boston, MA, 3Boston Children’s Hospital, Boston, MA Mixed Infant Feeding - Direct Breastfeeding, Pumping and Feeding, and Formula Food Poses a Risk for Food Allergy in Early Childhood Joacy Magdalene Gerard Mathias1,2, Hongmei Zhang, PhD1, Wilfried Karmaus, MD, DrMed, MPH1, Nelis Soto-Ramirez, MPH, MS, PhD3 and Yan Shen1, 1University of Memphis, Memphis, TN, 2Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, 3University of South Carolina, Columbia, SC Response to Nasal Challenge Correlates with Seasonal Outcomes during Grass Pollen Immunotherapy with Either Subcutaneous or Sublingual Immunotherapy Guy Scadding, MD PhD1, Aarif O. Eifan, MD1, Moises A Calderon, MD, PhD1, Mohamed H. Shamji, PhD1, Martin Penagos, MD1, Peter A. Wurtzen, PhD2, Michelle L. Sever, PhD3, Henry T. Bahnson, MPH3, Kaitie Lawson, MS3, Kristina M. Harris, PhD4, Tielin Qin, Biostatistics4, Noha Lim, PhD4, Audrey Plough, RN5, Nadia K. Tchao, MD5, Alkis Togias, MD, FAAAAI6 and Stephen R. Durham, MA, MD, FRCP1, 1Imperial College London, London, United Kingdom, 2ALK-Abelle, Hoersholm, Denmark, 3Rho, Inc., Chapel Hill, NC, 4Immune Tolerance Network, Bethesda, MD, 5Immune Tolerance Network, San Francisco, CA, 6NIAID/NIH, Bethesda, MD A Double Blind Placebo Controlled Study Documenting the Effect of Nasally Applied Cellulose-Derived Powder in Subjects Sensitized to Grass Pollen Todor A. Popov, MD, PhD, Sofia Medical University, Sofia, Bulgaria, Jean C Emberlin, Allergy UK, Sidcuo, Kent, United Kingdom and Nils Aberg, University of Gothenburg, Askim, Sweden Omalizumab Efficacy in Severe Asthma without Allergenic Sensitization Blanca De Vega Sanchez, MD1, Vicente Roig Figueroa, MD2, Agueda Herrero Perez, MD2, Enrique Macıas Fernandez, MD2, Angel Santiago, MD4, Vielba Due~nas David, MD5 and Ramos Cancelo Isabel, MD6, 1Hospital Clınico Universitario Valladolid,
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Valladolid, Spain, 2Hospital Clınico Universitario de Valladolid, Valladolid, Spain, 3Hospital Clınico Universitario de Valladolid, Valladolid, Spain, 4Hospital Clınico Universitario Valladolid, Valladolid, Spain, 5Hospital Clınico Universitario Valladolid, Valladollid, Spain, 6Hospital Clinico Universitario Valladolid, Valladolid, Spain Dietary Management of Eosinophilic Esophagitis (EoE): An International Survey Hannah Hunter, RD, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom, Liane Reeves, MSc, RD, Oxford Health NHS Foundation Trust, Oxford, United Kingdom, Carina Venter, PhD, RD, Cincinnati Childrens Hospital Medical Center, Cincinnati, OH and Rosan Meyer, PhD, RD, Imperial College London, London, United Kingdom Life after Peanut Immunotherapy Megan Ott Lewis, MSN, RN, CPNP1, Terri F. Brown-Whitehorn, MD, FAAAAI1, Deirdre D. Burke, CRC III2, Antonella Cianferoni, MD, PhD, FAAAAI3, Jennifer Heimall, MD4, Ashwini Reddy, MD2, Courtney Rooney, BSN, RN1, Jessica Wiedmann, RN2 and Jonathan M. Spergel, MD, PhD, FAAAAI2, 1 The Children’s Hospital of Philadelphia, Philadelphia, PA, 2Children’s Hospital of Philadelphia, Philadelphia, PA, 33615 Civic Center Boulevard, Children’s Hospital of Philadelphia, Philadelphia, PA, 4CHOP, Philadelphia, PA The Role of Gender in the Association Between Obesity and Atopic Disease in Urban Children Sairaman Nagarajan, MD, MPH1, Cynthia Yan, MD1, Kusum M Pradhan, MD1 and Maria-Anna Vastardi, MD1,2, 1SUNY Downstate Medical Center, Brooklyn, NY, 2Center for Allergy and Asthma Research, State University of New York Downstate Medical Center, Brooklyn, NY A Randomized Controlled Trial of an Intensive Integrated Pest Management Intervention on Asthma Morbidity Among Children and Adolescents Elizabeth Matsui, MD, MHS1, Matthew S. Perzanowski, PhD2, Roger D. Peng, PhD3, Robert A Wise3, Susan L. Balcer-Whaley, MPH3, Michelle Newman, RN3, Amparito Cunningham4, Adnan Divjan5, Mary E. Bollinger, DO, FAAAAI6, Shuyan Zhai, PhD7, Ginger L. Chew, ScD8, Rachel Miller9 and Wanda Phipatanakul, MD, MS, FAAAAI10, 1Division of Pediatric Allergy/Immunology, Johns Hopkins School of Medicine, Baltimore, MD, 2Department of Environmental Health Sciences, Columbia University, New York, NY, 3Johns Hopkins University, Baltimore, MD, 4Boston Children’s Hospital, Boston, 5Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 6University MD School of Medicine, Baltimore, MD, 7Johns Hopkins University, Baltimore, 8CDC (Centers for Dis. Control and Prev.), Atlanta, GA, 9Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, NY, 10Boston Children’s Hospital, Hopkinton, MA
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Secondhand Smoke Exposure in Early Life and Food-Related Symptoms through Adolescence: Population-Based Prospective Cohort Study Laura Feldman, MPH, HBSc1, Jesse Thacher, MPH2, Marianne van Hage, MD, PhD, FAAAAI3,4, Erik Melen, MD, PhD2, G€oran Pershagen, MD, PhD2, Magnus Carl Wickman3,5, Teresa To, PhD, MS6, Jennifer L. Protudjer, PhD3,7 and Anna Bergstr€om, PhD2, 1 The Hospital for Sick Children, Toronto, ON, Canada, 2Karolinska Institutet, Stockholm, Sweden, 3Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden, 4Karolinska Institutet, Department of Medicina Solna, Clinical Immunology and Allergy Unit, Stockholm, Sweden, 5Nat’l Inst. of Environ. Medicine, Stockholm, Sweden, 6Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, 7Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Time to Onset of Action for Loratadine Tablets Versus Placebo: a Post Hoc Analysis of a Study Conducted Using the Environmental Exposure Unit Charlene Ng, Bayer, Whippany, NJ Immune Inflammatory Consequences of Mutations in the Autophagy Gene ATG9A Pia J. Hauk, MD1, Michael J Morgan, PhD2, Courtney Banks, BA3, Tsz-Yin Chan, BS3, Jordan K Abbott, MD1, Michaela Schedel, PhD1, Robin R. Deterding, MD4, Bradford R. Miller, MD4, Joshua L. Andersen, PhD3, and Erwin W Gelfand, MD1, 1 National Jewish Health, Denver, CO, 2Rm. L18-6110, University of Colorado Denver, Department of Pharmacology, Aurora, CO, 3 Brigham Young University, Department of Chemistry and Biochemistry, Provo, UT, 4Children’s Hospital Colorado, Aurora, CO Integration of the Asthma APGAR into Primary Care Practices Improves Patient Reported Asthma Outcomes and Practices’ Adherence to Elements of Asthma Guidelines: A Radomized Controlled Trial Barbara P Yawn, MD, MSc, FAAFP, University of Minnesota, Minneapolis, MN and Matthew A. Rank, MD, FAAAAI, Mayo Clinic Arizona, Scottsdale, AZ The Pharmacist’s Voice in the Collaborative Care of Patients with Asthma Tonya A. Winders, MBA, Allergy & Asthma Network, Vienna, VA The Asthma Adherence Pathway (AAP) Improves Adherence As Well As Asthma Control Andrew G. Weinstein, MD, FAAAAI1, Deborah A. Gentile, MD2, Anil Singh3, Jennifer Maiolo3, David P. Skoner, MD4, Allison Kong3, Tajpreet Lamba5, Rihab Sharara5, Keit Ma5, and Erica Butler5, 1Sidney Kimmel Medical College Thomas Jefferson University, Rockland, DE, 2Allegheny Health Network, Pittsburgh, PA, 3Allegheny Health Network, Pittsburgh, 4Department of Medicine, Allegheny General Hospital, Pittsburgh, PA, 5allegheny Health Network, pittsburgh
MONDAY
Abstracts AB393
J ALLERGY CLIN IMMUNOL VOLUME 139, NUMBER 2
J ALLERGY CLIN IMMUNOL FEBRUARY 2017
SATURDAY
Late-Breaking Abstract Sessions Late Breaking Oral Abstract Session Basic Science
Clinical/Translational Science 3611 Sunday, March 5th, 2017, 2:00 PM - 3:15 PM L6
2611 Saturday, March 4th, 2017, 2:00 PM - 3:15 PM L1
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Airway Exosomes from Asthmatics Modulate Differential T Helper Responses Jessy Deshane, PhD, Kenneth Hough, BS, Landon Wilson, BS, Marion Spell, BS, Jennifer L Trevor, MD, Diptiman Chanda, PhD, Jose Rodriguez Dager, BS, Yong Wang, PhD, Stephen Barnes, PhD, Veena Antony, MD, Chad Steele, PhD, Mark Dransfield, MD, Steven Duncan, MD, Jeevan Prasain, PhD and Victor Thannickal, MD, University of Alabama at Birmingham, Birmingham, AL Prostaglindin I2 Orchestrates Regulatory and Effector T CellMediated Autoimmunity Melissa H. Bloodworth1, Kelli L. Boyd1, Lisa M. Rogers2, David M. Aronoff2 and Stokes Peebles Jr, MD, FAAAAI3, 1 Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, 2Division of Infectious Diseases, Vanderbilt University, Nashville, TN, 3Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, TN Immune Differences in Asthmatic Children Using Mass Cytometry Tara Paglino1, Mary Prunicki1, Xiaoying Zhou1 and Kari C Nadeau, MD, PhD, FAAAAI2, 1Stanford, Stanford, 2Stanford University, Stanford, CA Maternal DNA Methylation in Second Half of Pregnancy in Th1, Th2, Th17 and Treg Pathway Genes Differs with Birth-Order Orpita Nilormee, BDS, MPH1, Gabrielle A. Lockett, PhD2, Sabrina Iqbal, BDS, MPH3, John W. Holloway, PhD2, Syed H. Arshad, DM, FRCP4, Hongmei Zhang, PhD1 and Wilfried Karmaus5, 1The University of Memphis, Memphis, TN, 2 University of Southampton, Southampton, United Kingdom, 3 The University Of Memphis, Memphis, TN, 4University of Southampton, Isle of Wright, United Kingdom, 5Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, The University of Memphis, Memphis, TN Immunogenicity of 50-Valent Rhinovirus Vaccine Sujin Lee, PhD1,2, Minh Trang Nguyen1, Michael G Currier1, Joe B Jenkins, PhD3, Elizabeth A Strobert3, Adriana E Kajon, PhD4, Ranjna Madan-Lala, PhD5, Yury A. Bochkov, PhD6, James E. Gern, MD, FAAAAI7, Krishnendu Roy, PhD5, Xiaoyan Lu8, Dean D Erdman, PhD8, Paul Spearman, MD3 and Martin L. Moore, PhD1,2, 1Emory University, Atlanta, GA, 2Children’s Healthcare of Atlanta, Atlanta, GA, 3Emory University, Atlanta, 4Lovelace Respiratory Research Institute, Albuquerque, 5Georgia Tech, Atlanta, 6University of Wisconsin-Madison, Madison, WI, 7University of Wisconsin School of Medicine and Public Health, Madison, WI, 8CDC, Atlanta
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TPSAB1 Genotype and Effects of Pro-Tryptases on Human Mast Cell-Associated Disorders Jonathan Lyons, MD1, Jack Chovanec, BS1, Yihui Liu, PhD1, Quang T Le, PhD2, Yun Bai, MS3, Amy P Hsu, BA4, Hirsh D. Komarow, MD3, Melody C. Carter, MD, FAAAAI3, Lawrence B. Schwartz, MD, PhD2, Dean D. Metcalfe, MD3, and Joshua D. Milner, MD1, 1NIH/NIAID/LAD/GPAS, Bethesda, 2Virginia Commonwealth University, Richmond, VA, 3NIH/ 4 NIH/NIAID/LAD/LCID, NIAID/LAD/MCBS, Bethesda, Bethesda Efficacy and Safety of Long-Term Epicutaneous Immunotherapy (EPIT) Treatment of Peanut Allergy with ViaskinÒ peanut: Results of the Two-Year Extension of the Vipes Phase IIb Clinical Trial Wayne G. Shreffler, MD, PhD, FAAAAI, Masschusetts General Hospital, Boston, MA; Division of Allergy and Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, Kari C Nadeau, MD, PhD, FAAAAI, Stanford University, Stanford, CA, Stephanie A. Leonard, MD, Division of Pediatric Allergy & Immunology, Rady Children’s Hospital, San Diego, CA; Rady Children’s Hospital/ UCSD, San Diego, CA, Gordon L. Sussman, MD, FAAAAI, University of Toronto, Toronto, ON, Canada and Hugh A. Sampson, MD FAAAAI, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY Evaluation of Risk Factors for Infections and Systemic Reactions (SRs) Associated with Subcutaneous and Sublingual Allergen Immunotherapy (SCIT and SLIT): AAAAI/ACAAI National Surveillance Study 2008-2015 Tolly Epstein, MD, MS, FAAAAI1, Gary M. Liss, MD, MS FRCPC2, Karen J. Murphy-Berendts, BS, RRT, CCRC3 and David I. Bernstein, MD, FAAAAI3,4, 1University of Cincinnati Division of Immunology, Allergy, & Rheumatology, Cincinnati, OH, 2 University of Toronto, Toronto, ON, Canada, 3Bernstein Clinical Research Center, LLC, Cincinnati, OH, 4University of Cincinnati College of Medicine, Cincinnati, OH The Impact of an Integrated Antibiotic Allergy Testing Program on Antimicrobial Stewardship: A Multicentre Evaluation Jason A. Trubiano, MBBS, FRACP1,2, Karen Thursky3, Andrew J Stewardson1, Karen Urbancic1, Leon J Worth3, Michael Sutherland1, Monica A Slavin3, M Lindsay Grayson1 and Elizabeth J. Phillips, MD4,5, 1Austin Health, Melbourne, Australia, 2 University of Melbourne, Melbourne, Australia, 3Peter MacCallum Cancer Centre, Melbourne, Australia, 4Institute for Immunology & Infectious Diseases, Murdoch University, Murdoch, Australia, 5Vanderbilt University School of Medicine, Division of Infectious Diseases, Department of Medicine, Nashville, TN Randomized Placebo-Controlled Multicenter Clinical Trial of Wheat Oral Immunotherapy Anna H. Nowak-Wegrzyn, MD, PhD, FAAAAI1, Robert A. Wood, MD, FAAAAI2, Kari C Nadeau, MD, PhD, FAAAAI3,
Abstracts AB391
J ALLERGY CLIN IMMUNOL VOLUME 139, NUMBER 2
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Potency, Selectivity, and Exposure Evaluation of ATN-249, a New Oral Kallikrein Inhibitor for Hereditary Angioedema Ira Kalfus, MD, Andrew McDonald, PhD and Shawn Qian, PhD, Attune Pharmaceuticals, LLC, New York City, NY Influence of Conformational and Linear IgE Epitopes on Ara h 2-Specific IgE-Binding Angelika Tscheppe, MSc1, Dieter Palmberger, PhD2, Christian Radauer, PhD1, Merima Bublin, PhD1, Christine Hafner, MD3, Wolfgang Hemmer, PhD4, Vanessa Mayr, MSc1, Chiara Palladino, MSc1, Barbara Gepp, PhD1, Nina Lengger, BMA1, Reingard Grabherr, PhD2 and Heimo Breiteneder, PhD1, 1Medical University of Vienna, Vienna, Austria, 2University of Natural Resources and Life Sciences, Vienna, Austria, 3Karl Landsteiner University of Health Science, St.Poelten, Austria, 4Floridsdorf Allergy Center, Vienna, Austria Differential Role of Foxp3+ Regulatory T Cells during Allergen Sensitization and Challenge Booki Min, DVM, PhD, Lerner Research Institute/NB30, Cleveland, OH Roflumilast Ameliorates Ovalbumin-Induced Neutrophilic Airway Inflammation in Mice: Role of CD4+ CD25+ FOXP3+ Regulatory T-Cells Mohamed G. Elsakkar Sr1, Olla A. Sharaki2, Dina M. Abdallah2, Dalia K. Mostafa2 and Fadia T. Shekondali3, 1Alexandria University, Alexandria, Egypt, Alexandria, Egypt, 2Faculty of Medicine, Alexandria University, Alexandria, Egypt, Alexandria, Egypt, 3Faculty of Medicine, EL-Zawia University, Libya, ELZawia, Libya Covalent Heterbivalent Inhibitors for Food Allergies Peter E. Deak, University of Notre Dame, Notre Dame, IN and Basar Bilgicer, PhD, University of Notre Dame, Notre Dame The National Burden of Asthma in Children in the U.S.: Results from a Nationally Representative Study Patrick W. Sullivan, PhD1, Vahram Ghushchyan, PhD2, Prakash Navaratnam, PhD3, Howard Friedman, PhD3, Abhishek Kavati, PhD4, Pin Xiang, PhD5, Benjamin Ortiz, MD6, and Bobby Q. Lanier, MD, FAAAAI7, 1Regis University, Denver, CO, 2University of Colorado Denver, Denver, 3DataMed Solutions, New York, NY, 4 Novartis Pharmaceuticals Inc., East Hanover, NJ, 5Novartis Pharmaceuticals, Inc., East Hanover, NJ, 6Novartis Pharmaceuticals Corporation, East Hanover, NJ, 7North TX Institute for Clinical Trials, Fort Worth, TX Mepolizumab Significantly Improves Health Status and Asthma Control in Severe Eosinophilic Asthma: The Musca Study - a Phase IIIb Randomized, Placebo-Controlled Trial Geoffrey L Chupp, MD1, Eric S Bradford2, Frank C Albers2, Daniel J Bratton3, Jie Wang-Jairaj, PhD3, Linda M Nelsen4, Jennifer L Trevor, MD5, Antoine Magnan, MD6 and Anneke ten Brinke, MD7, 1Yale School of Medicine, New Haven, CT,
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GSK, Research Triangle Park, NC, 3GSK, Stockley Park, United Kingdom, 4GSK, Collegeville, PA, 5University of Alabama at Birmingham, Birmingham, AL, 6Universite de Nantes, Nantes, France, 7Medical Centre Leeuwarden, Leeuwarden, Netherlands Mepolizumab Improves Lung Function and Exacerbation Rates in Severe Eosinophilic Asthma: The Musca Study - a Phase IIIb Randomized, Placebo-Controlled Tria Jennifer L Trevor, MD1, Eric S Bradford2, Frank C Albers2, Daniel J Bratton3, Jie Wang-Jairaj, PhD3, Linda M Nelsen4, Geoffrey L Chupp, MD5, Antoine Magnan, MD6, and Anneke ten Brinke, MD7, 1University of Alabama at Birmingham, Birmingham, AL, 2GSK, Research Triangle Park, NC, 3GSK, Stockley Park, United Kingdom, 4GSK, Collegeville, PA, 5Yale School of Medicine, New Haven, CT, 6Universite de Nantes, Nantes, France, 7Medical Centre Leeuwarden, Leeuwarden, Netherlands Development of Specific Electronic Phenotypes for Severe Cutaneous Adverse Drug Reactions Facilitates Genetic Discovery Sarah Garon, MD1, Lincoln Shade, BSc1, Michael I. Derrick, MD1, Adrian Bejan, PhD1, and Elizabeth J. Phillips, MD1,2, 1Vanderbilt University Medical Center, Nashville, TN, 2Institute for Immunology & Infectious Diseases, Murdoch University, Murdoch, Australia Outcome of 583 Entry Double-Blind Placebo-Controlled Peanut Challenges during Screening for the Palisade Phase 3 Oral Immunotherapy Trial Brian P. Vickery, MD, FAAAAI1,2, Kirsten Beyer, MD3, A. Wesley Burks, MD, FAAAAI4, Thomas B. Casale, MD, FAAAAI5, Jonathan O. Hourihane, MD, FAAAAI6, Stacie M. Jones7, Amr Radwan, MBBChir, FFPM8, Andrea Vereda, MD, PhD8, and Daniel C. Adelman, MD, FAAAAI8,9, 1University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Aimmune Therapeutics, Brisbane, CA, 3Charite Universitatsmedizin Berlin, Berlin, Germany, 4University of North Carolina, Chapel Hill, NC, 5 University of South Florida, Tampa, FL, 6University College Cork, Cork, Ireland, 7Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, AR, 8Aimmune Therapeutics Inc, Brisbane, CA, 9 University of California, San Francisco, Redwood City, CA Long-Term Safety and Efficacy of Open-Label Dupilumab in Patients with Moderate-to-Severe Atopic Dermatitis Mette Deleuran1, Diamant Thac¸i2, Lisa A. Beck, MD, FAAAAI3, Seth Forman4, Weily Soong, MD, FAAAAI5, Iftikhar Hussain6, Robert Bissonnette7, Jean-David Bouaziz8, Joel Gelfand9, Lawrence Sher10, Zhen Chen11, Bolanle Akinlade11, Abhijit Gadkari11, Laurent Eckert12, Neil MH Graham11, Gianluca Pirozzi13, and Marius Ardeleanu11, 1Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark, 2Comprehensive Center for Inflammation Medicine, University Hospital Schleswig-Holstein, Lubeck, Germany, 3Depts of Dermatology and Microbiology, University of Rochester Medical Center, Rochester, NY, 4Forman Dermatology and Skin Cancer Institute, Tampa, FL, 5Alabama Allergy & Asthma Center, Birmingham, AL, 6Vital Prospects Clinical Research Institute, PC, Tulsa, OK, 7Innovaderm Research, Montreal, QC, Canada, 8Dermatology Department, Saint-Louis Hospital, Paris, France, 9Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, 10Peninsula Research Associates, Rolling Hills Estates, CA, 11Regeneron Pharmaceuticals, Tarrytown, NY, 12Sanofi, Chilly-Mazarin, France, 13Sanofi, Bridgewater, NJ DNA Methylation Status Predicts Response to Inhaled Corticosteroids in Pediatric Asthmatics Alberta L. Wang, MD1,2, Weiliang Qiu, PhD2, and Kelan G. Tantisira, MD, MPH2, 1Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 2 Channing Division of Network Medicine, Department of
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Jacqueline A. Pongracic, MD, FAAAAI4, Alice Henning5, Kirsten Beyer, MD6, Robert W. Lindblad, MD5, and Hugh A. Sampson, MD, FAAAAI7,8, 1Icahn School of Medicine at Mount Sinai, New York, NY, 2Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, 3Stanford University, Stanford, CA, 4Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 5The EMMES Corporation, Rockville, MD, 6Charite - Universitaetsmedizin Berlin, Berlin, Germany, 7 Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 8DBV Technologies, New York, NY
AB392 Abstracts
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Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston The Effects of Inhaled Fluticasone Propionate on Seasonal Exacerbations in Preschool-Aged Children at High Risk for Asthma William C. Anderson, MD1, John T. Brinton, PhD2, Lance Ford, BS2, Shelby Lineberry2, Casey Sakamoto2, Marie Tomisato2, Robert S. Zeiger, MD, PhD, FAAAAI3,4, Robert F. Lemanske, MD, FAAAAI5, Fernando D. Martinez, MD6, Theresa W. Guilbert, MD, MS7, Leonard B. Bacharier, MD8, David M. Mauger, PhD9, and Stanley J. Szefler, MD, FAAAAI1, 1Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, 2 Colorado Summer Institute in Biostatistics, Department of Biostatistics and Informatics, University of Colorado School of Public Health, Aurora, CO, 3University of California, La Jolla, CA, 4 Kaiser Permanente Southern California, San Diego, CA, 5Departments of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 6Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, 7Department of Pediatrics, Asthma Center, Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 8Department of Pediatrics, Washington University School of Medicine and St. Louis Children’s Hospital, St. Louis, MO, 9Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA Pilot Study of Asthmawin Mobile Iphone App in the Management of Asthma Elena R. Reece, MD, Howard University, Washington, DC, Autumn F. Burnette, MD, Howard University, Arlington, VA and Cassia J. Lewis-Land, MA, Johns Hopkins University, Baltimore, MD A New Liquid 10% Intravenous Immunoglobulin (IVIG) Administered with 15-Minute Titration Periods Allows Shorter Infusion Durations and Tolerability Similar to a 5% Formulation Mark R. Stein, MD, FAAAAI1, Kelly Farnan, RMA, CCRC1, Danielle Eufrasio, RMA, CCRC1, and Miranda Norton, PhD2, 1 Allergy Associates of the Palm Beaches, North Palm Beach, FL, 2Bio Products Laboratory, Elstree, United Kingdom Drug Allergy Training Opportunities in the United States: A Survey of Allergy and Immunology Program Directors Michael I. Derrick, MD1, Elizabeth McKinnon, PhD2 and Elizabeth J. Phillips, MD1,2, 1Vanderbilt University Medical Center, Nashville, TN, 2Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia Genotype-Phenotype Correlations in Patients with Hereditary Angioedema Luana S.M. Maia, MSc1, Mariana Paes Leme Ferriani, MD, PhD1, Fernanda Leonel Nunes, MD1, Maria Fernanda Ferraro, MD1, Marina Mendonca Dias, Chem1, Faradiba Sarquis Serpa, MD, MSc2, Antonio Abilio Motta3, Solange Rodrigues Valle, MD, PhD4, Wilson Araujo Silva-Jr, PhD1, Davi Casale Aragon, MSc1, Willy Sarti, MD, PhD1, Luisa Karla P. Arruda, MD PhD FAAAAI1 and Adriana S. Moreno, PhD1, 1Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil, 2School of Medicine of Santa Casa de Misericordia of Vitoria, Vitoria, Brazil, 3Clinical Immunology and Allergy Division of Sao Paulo University, Sao Paulo, Brazil, 4Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Activation of the Complement, Coagulation and Fibrinolysis Pathways after Nasal Allergen Challenge Ryan S Thwaites, PhD1, Natasha C. Gunawardana, MD1, Verena L Broich, MSc1, Elizabeth H Mann, PhD2, Gaynor A Campbell, PhD1, Tanushree Tunstall, MSc1, Sarah Lindsley1, Catherine M. Hawrylowicz, PhD2, Peter J.M. Openshaw, MBBS, PhD, FRCP3, and Trevor T. Hansel, MD PhD1, 1National Heart and
J ALLERGY CLIN IMMUNOL FEBRUARY 2017
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Lung Institute, London, United Kingdom, 2MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, London, United Kingdom, 3Imperial Col Sch Med, St. Mary’s Hospital, London, United Kingdom KIF3A genetic Variation Is Associated with a Pediatric Asthma Phenotype Characterized By Past or Current Eczema Independent of Allergic Rhinitis Elisabet Johansson, PhD1, Jocelyn M. Biagini Myers, PhD1, Lisa J. Martin, PhD1, Hua He, MS1, Valentina Pilipenko, PhD1, Tesfaye B Mersha, PhD1, Matthew T. Weirauch, PhD1, Nathan Salomonis, PhD1, Patrick H. Ryan, PhD1, Grace K. LeMasters, PhD2, David I. Bernstein, MD FAAAAI2, James E. Lockey, MD MS FAAAAI2, and Gurjit (Neeru) K Khurana Hershey, MD, PhD1, 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2University of Cincinnati College of Medicine, Cincinnati, OH Efficacy of Zileuton in Patients with Asthma and History of Aspirin Sensitivity: A Retrospective Analysis of Data from Two Phase 3 Studies Tanya M. Laidlaw, MD, FAAAAI, Brigham and Women’s Hospital, Division of Rheumatology, Immunology, and Allergy, Boston, MA, Daniel J. Fuentes, PharmD, Chiesi USA, Cary, NC and Yi Wang, PhD, FMD K&L, Fort Washington, PA Understanding Anaphylaxis in Camps: A Study Measuring Demographics, Knowledge, and Incidence of Allergic Reactions Margaret Redmond, MD1, Michael Pistiner, MD, MMSc2, Rebecca Scherzer, MD, FAAAAI1, Frank J. Twarog, MD, PhD, FAAAAI3, David R. Stukus, MD, FAAAAI1, and John Lee, MD3, 1Nationwide Children’s Hospital, Columbus, OH, 2Harvard Vanguard Medical Associates, Boston, MA, 3Boston Children’s Hospital, Boston, MA Mixed Infant Feeding - Direct Breastfeeding, Pumping and Feeding, and Formula Food Poses a Risk for Food Allergy in Early Childhood Joacy Magdalene Gerard Mathias1,2, Hongmei Zhang, PhD1, Wilfried Karmaus, MD, DrMed, MPH1, Nelis Soto-Ramirez, MPH, MS, PhD3 and Yan Shen1, 1University of Memphis, Memphis, TN, 2Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, 3University of South Carolina, Columbia, SC Response to Nasal Challenge Correlates with Seasonal Outcomes during Grass Pollen Immunotherapy with Either Subcutaneous or Sublingual Immunotherapy Guy Scadding, MD PhD1, Aarif O. Eifan, MD1, Moises A Calderon, MD, PhD1, Mohamed H. Shamji, PhD1, Martin Penagos, MD1, Peter A. Wurtzen, PhD2, Michelle L. Sever, PhD3, Henry T. Bahnson, MPH3, Kaitie Lawson, MS3, Kristina M. Harris, PhD4, Tielin Qin, Biostatistics4, Noha Lim, PhD4, Audrey Plough, RN5, Nadia K. Tchao, MD5, Alkis Togias, MD, FAAAAI6 and Stephen R. Durham, MA, MD, FRCP1, 1Imperial College London, London, United Kingdom, 2ALK-Abelle, Hoersholm, Denmark, 3Rho, Inc., Chapel Hill, NC, 4Immune Tolerance Network, Bethesda, MD, 5Immune Tolerance Network, San Francisco, CA, 6NIAID/NIH, Bethesda, MD A Double Blind Placebo Controlled Study Documenting the Effect of Nasally Applied Cellulose-Derived Powder in Subjects Sensitized to Grass Pollen Todor A. Popov, MD, PhD, Sofia Medical University, Sofia, Bulgaria, Jean C Emberlin, Allergy UK, Sidcuo, Kent, United Kingdom and Nils Aberg, University of Gothenburg, Askim, Sweden Omalizumab Efficacy in Severe Asthma without Allergenic Sensitization Blanca De Vega Sanchez, MD1, Vicente Roig Figueroa, MD2, Agueda Herrero Perez, MD2, Enrique Macıas Fernandez, MD2, Angel Santiago, MD4, Vielba Due~nas David, MD5 and Ramos Cancelo Isabel, MD6, 1Hospital Clınico Universitario Valladolid,
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Valladolid, Spain, 2Hospital Clınico Universitario de Valladolid, Valladolid, Spain, 3Hospital Clınico Universitario de Valladolid, Valladolid, Spain, 4Hospital Clınico Universitario Valladolid, Valladolid, Spain, 5Hospital Clınico Universitario Valladolid, Valladollid, Spain, 6Hospital Clinico Universitario Valladolid, Valladolid, Spain Dietary Management of Eosinophilic Esophagitis (EoE): An International Survey Hannah Hunter, RD, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom, Liane Reeves, MSc, RD, Oxford Health NHS Foundation Trust, Oxford, United Kingdom, Carina Venter, PhD, RD, Cincinnati Childrens Hospital Medical Center, Cincinnati, OH and Rosan Meyer, PhD, RD, Imperial College London, London, United Kingdom Life after Peanut Immunotherapy Megan Ott Lewis, MSN, RN, CPNP1, Terri F. Brown-Whitehorn, MD, FAAAAI1, Deirdre D. Burke, CRC III2, Antonella Cianferoni, MD, PhD, FAAAAI3, Jennifer Heimall, MD4, Ashwini Reddy, MD2, Courtney Rooney, BSN, RN1, Jessica Wiedmann, RN2 and Jonathan M. Spergel, MD, PhD, FAAAAI2, 1 The Children’s Hospital of Philadelphia, Philadelphia, PA, 2Children’s Hospital of Philadelphia, Philadelphia, PA, 33615 Civic Center Boulevard, Children’s Hospital of Philadelphia, Philadelphia, PA, 4CHOP, Philadelphia, PA The Role of Gender in the Association Between Obesity and Atopic Disease in Urban Children Sairaman Nagarajan, MD, MPH1, Cynthia Yan, MD1, Kusum M Pradhan, MD1 and Maria-Anna Vastardi, MD1,2, 1SUNY Downstate Medical Center, Brooklyn, NY, 2Center for Allergy and Asthma Research, State University of New York Downstate Medical Center, Brooklyn, NY A Randomized Controlled Trial of an Intensive Integrated Pest Management Intervention on Asthma Morbidity Among Children and Adolescents Elizabeth Matsui, MD, MHS1, Matthew S. Perzanowski, PhD2, Roger D. Peng, PhD3, Robert A Wise3, Susan L. Balcer-Whaley, MPH3, Michelle Newman, RN3, Amparito Cunningham4, Adnan Divjan5, Mary E. Bollinger, DO, FAAAAI6, Shuyan Zhai, PhD7, Ginger L. Chew, ScD8, Rachel Miller9 and Wanda Phipatanakul, MD, MS, FAAAAI10, 1Division of Pediatric Allergy/Immunology, Johns Hopkins School of Medicine, Baltimore, MD, 2Department of Environmental Health Sciences, Columbia University, New York, NY, 3Johns Hopkins University, Baltimore, MD, 4Boston Children’s Hospital, Boston, 5Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 6University MD School of Medicine, Baltimore, MD, 7Johns Hopkins University, Baltimore, 8CDC (Centers for Dis. Control and Prev.), Atlanta, GA, 9Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, NY, 10Boston Children’s Hospital, Hopkinton, MA
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Secondhand Smoke Exposure in Early Life and Food-Related Symptoms through Adolescence: Population-Based Prospective Cohort Study Laura Feldman, MPH, HBSc1, Jesse Thacher, MPH2, Marianne van Hage, MD, PhD, FAAAAI3,4, Erik Melen, MD, PhD2, G€oran Pershagen, MD, PhD2, Magnus Carl Wickman3,5, Teresa To, PhD, MS6, Jennifer L. Protudjer, PhD3,7 and Anna Bergstr€om, PhD2, 1 The Hospital for Sick Children, Toronto, ON, Canada, 2Karolinska Institutet, Stockholm, Sweden, 3Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden, 4Karolinska Institutet, Department of Medicina Solna, Clinical Immunology and Allergy Unit, Stockholm, Sweden, 5Nat’l Inst. of Environ. Medicine, Stockholm, Sweden, 6Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, 7Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Time to Onset of Action for Loratadine Tablets Versus Placebo: a Post Hoc Analysis of a Study Conducted Using the Environmental Exposure Unit Charlene Ng, Bayer, Whippany, NJ Immune Inflammatory Consequences of Mutations in the Autophagy Gene ATG9A Pia J. Hauk, MD1, Michael J Morgan, PhD2, Courtney Banks, BA3, Tsz-Yin Chan, BS3, Jordan K Abbott, MD1, Michaela Schedel, PhD1, Robin R. Deterding, MD4, Bradford R. Miller, MD4, Joshua L. Andersen, PhD3, and Erwin W Gelfand, MD1, 1 National Jewish Health, Denver, CO, 2Rm. L18-6110, University of Colorado Denver, Department of Pharmacology, Aurora, CO, 3 Brigham Young University, Department of Chemistry and Biochemistry, Provo, UT, 4Children’s Hospital Colorado, Aurora, CO Integration of the Asthma APGAR into Primary Care Practices Improves Patient Reported Asthma Outcomes and Practices’ Adherence to Elements of Asthma Guidelines: A Radomized Controlled Trial Barbara P Yawn, MD, MSc, FAAFP, University of Minnesota, Minneapolis, MN and Matthew A. Rank, MD, FAAAAI, Mayo Clinic Arizona, Scottsdale, AZ The Pharmacist’s Voice in the Collaborative Care of Patients with Asthma Tonya A. Winders, MBA, Allergy & Asthma Network, Vienna, VA The Asthma Adherence Pathway (AAP) Improves Adherence As Well As Asthma Control Andrew G. Weinstein, MD, FAAAAI1, Deborah A. Gentile, MD2, Anil Singh3, Jennifer Maiolo3, David P. Skoner, MD4, Allison Kong3, Tajpreet Lamba5, Rihab Sharara5, Keit Ma5, and Erica Butler5, 1Sidney Kimmel Medical College Thomas Jefferson University, Rockland, DE, 2Allegheny Health Network, Pittsburgh, PA, 3Allegheny Health Network, Pittsburgh, 4Department of Medicine, Allegheny General Hospital, Pittsburgh, PA, 5allegheny Health Network, pittsburgh
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Abstracts AB393
J ALLERGY CLIN IMMUNOL VOLUME 139, NUMBER 2