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Mass spectrometry: Innovation and application—Part VIII
G Model
ARTICLE IN PRESS
CHROMA-357314; No. of Pages 2
Journal of Chromatography A, xxx (2016) xxx–xxx
Contents lists available at ScienceDirect
Journal of Chromatography A journal homepage: www.elsevier.com/locate/chroma
Foreword
Mass spectrometry: Innovation and application—Part VIII
This special issue is already the eighth in the series on Mass spectrometry: Innovation and application, which has been published in Journal of Chromatography A during the last 15 years. It clearly demonstrates that the field of the hyphenation of mass spectrometry to separation techniques is still flourishing with new technical innovations and an extending range of cutting-edge applications. Two review articles and fourteen original papers are published in this special issue, including both instrumentation orientated papers (high-resolution LC–MS/MS, GC–MS, GC × GC/MS, LC × GC–MS, TLC–ESI-MS, microfluidics-MS, ion mobility-MS, NPLC/APPI-MS) and interesting applications focused on proteomics, metabolomics, lipidomics, drug metabolites, quantitation, matrix effects, biological samples, food analysis, emerging environmental pollutants, etc. The first review depicts the potential of various ion mobility approaches as an additional separation dimension to LC–MS. The second review describes the state of art in the comprehensive “omics” analysis of extracellular vesicles. Matrix effects are still a very important issue particularly in quantitative LC–MS, as illustrated by two papers devoted to the systematic study of these adverse effects. The systematic evaluation of matrix effects in HILIC vs. RPLC-MS/MS is reported for selected pharmaceutical compounds and doping agents, including the effect of various sample-pretreatment protocols on matrix effects. Knowledge of matrix effects in the analysis of DNA adducts of polycyclic aromatic hydrocarbons is used for the development of a validated HPLC-ESIMS method for the determination of target biomarkers in biological samples. Two papers describe the LC–MS/MS quantitation (low- vs. high-resolution MS approaches) of metabolites or oxysterols in biological samples, including human plasma, red blood cells and mice tissues. Microfluidic techniques coupled with hydrogen-deuterium exchange measurements allow the characterization of peptides and small proteins. The coupling of high-performance thin-layer chromatography and ESI-MS is successfully applied to study oxidation products of oleic acid. Two papers are exploring the potential of APPI coupled to normal-phase HPLC. Nonpolar sterols and polar phytosterol oxidation products are analyzed with the addition of dopant using a single method, while food emulsifiers are detected directly without any dopant. All three atmospheric pressure ionization techniques (ESI, APCI and APPI) are compared for the metabolic analysis of Fusarium oxysporum using high-resolution LC–MS-MS and post-column addition of Ca2+ , Cu2+ or Zn2+ solutions. Emerging pollutants are screened in wastewaters using high-resolution MS and a home-made library of their mass spectra. New technical
developments are also published in the area of GC–MS coupling. The first study describes the development of four-stage-flow modulation comprehensive GC × GC–MS and the second paper reports on an interesting application of LC × GC–MS in the identification of Mycobacterium tuberculosis. The Web-of-Science citation analysis of previous seven volumes in the series of Mass spectrometry: Innovation and application showed that the following five articles have attracted the highest attention from the scientific community based on average citations per year (as of February 10, 2016) and they belong to 1% of most cited papers in Journal of Chromatography A in specific years: Signal suppression/enhancement in high-performance liquid chromatography tandem mass spectrometry (27.86 citations/year) [1], Analytical strategies for residue analysis of veterinary drugs and growthpromoting agents in food-producing animals (26.08 citations/year) [2], Liquid chromatography-tandem mass spectrometry for the analysis of pharmaceutical residues in environmental samples: a review (24.75 citations/year) [3], Matrix effect in LC-ESI-MS and LC-APCI-MS with off-line and on-line extraction procedures (16.92 citations/year) [4], and Recent developments in liquid chromatography-mass spectrometry and related techniques (14.80 citations/year) [5]. Finally, we would like to express our thanks to all people involved in the preparation of this special issue starting from authors as key contributors to this work, reviewers and also the journal staff providing valuable support. The forthcoming HPLC symposia organized this June in San Francisco [6] and the next year in Prague [7] will provide next opportunities to present the latest scientific contributions on separation techniques and mass spectrometry. The 9th issue in the series may be published in conjunction with the latter conference.
References [1] F. Gosetti, E. Mazzucco, D. Zampieri, M.C. Gennaro, Signal suppression/enhancement in high-performance liquid chromatography tandem mass spectrometry, J. Chromatogr. A 1217 (25) (2010) 3929–3937. [2] A.A.M. Stolker, U.A.T. Brinkman, Analytical strategies for residue analysis of veterinary drugs and growth-promoting agents in food-producing animals—a review, J. Chromatogr. A 1067 (1–2) (2005) 15–53. [3] M. Petrovic, M.D. Hernando, M.S. Diaz-Cruz, D. Barcelo, Liquid chromatography-tandem mass spectrometry for the analysis of pharmaceutical residues in environmental samples: a review, J. Chromatogr. A 1067 (2005) 1–14. [4] S. Souverain, S. Rudaz, J.L. Veuthey, Matrix effect in LC–ESI-MS and LC–APCI-MS with off-line and on-line extraction procedures, J. Chromatogr. A 1058 (2004) 61–66.
http://dx.doi.org/10.1016/j.chroma.2016.02.040 0021-9673/© 2016 Elsevier B.V. All rights reserved.
Please cite this article in press as: M. Holˇcapek, et al., Mass spectrometry: Innovation and application—Part VIII, J. Chromatogr. A (2016), http://dx.doi.org/10.1016/j.chroma.2016.02.040
G Model CHROMA-357314; No. of Pages 2 2
ARTICLE IN PRESS Foreword / J. Chromatogr. A xxx (2016) xxx–xxx
[5] M. Holˇcapek, R. Jirásko, M. Lísa, Recent developments in liquid chromatography–mass spectrometry and related techniques, J. Chromatogr. A 1259 (2012) 3–15. [6] http://hplc2016.org [7] http://www.hplc2017-prague.org
∗ Corresponding author. E-mail address: [email protected] (M. Holˇcapek)
Available online xxx M. Holˇcapek ∗ Pardubice, Czech Republic P.J. Schoenmakers Amsterdam, The Netherlands G. Hopfgartner Geneva, Switzerland
Please cite this article in press as: M. Holˇcapek, et al., Mass spectrometry: Innovation and application—Part VIII, J. Chromatogr. A (2016), http://dx.doi.org/10.1016/j.chroma.2016.02.040
ARTICLE IN PRESS
CHROMA-357314; No. of Pages 2
Journal of Chromatography A, xxx (2016) xxx–xxx
Contents lists available at ScienceDirect
Journal of Chromatography A journal homepage: www.elsevier.com/locate/chroma
Foreword
Mass spectrometry: Innovation and application—Part VIII
This special issue is already the eighth in the series on Mass spectrometry: Innovation and application, which has been published in Journal of Chromatography A during the last 15 years. It clearly demonstrates that the field of the hyphenation of mass spectrometry to separation techniques is still flourishing with new technical innovations and an extending range of cutting-edge applications. Two review articles and fourteen original papers are published in this special issue, including both instrumentation orientated papers (high-resolution LC–MS/MS, GC–MS, GC × GC/MS, LC × GC–MS, TLC–ESI-MS, microfluidics-MS, ion mobility-MS, NPLC/APPI-MS) and interesting applications focused on proteomics, metabolomics, lipidomics, drug metabolites, quantitation, matrix effects, biological samples, food analysis, emerging environmental pollutants, etc. The first review depicts the potential of various ion mobility approaches as an additional separation dimension to LC–MS. The second review describes the state of art in the comprehensive “omics” analysis of extracellular vesicles. Matrix effects are still a very important issue particularly in quantitative LC–MS, as illustrated by two papers devoted to the systematic study of these adverse effects. The systematic evaluation of matrix effects in HILIC vs. RPLC-MS/MS is reported for selected pharmaceutical compounds and doping agents, including the effect of various sample-pretreatment protocols on matrix effects. Knowledge of matrix effects in the analysis of DNA adducts of polycyclic aromatic hydrocarbons is used for the development of a validated HPLC-ESIMS method for the determination of target biomarkers in biological samples. Two papers describe the LC–MS/MS quantitation (low- vs. high-resolution MS approaches) of metabolites or oxysterols in biological samples, including human plasma, red blood cells and mice tissues. Microfluidic techniques coupled with hydrogen-deuterium exchange measurements allow the characterization of peptides and small proteins. The coupling of high-performance thin-layer chromatography and ESI-MS is successfully applied to study oxidation products of oleic acid. Two papers are exploring the potential of APPI coupled to normal-phase HPLC. Nonpolar sterols and polar phytosterol oxidation products are analyzed with the addition of dopant using a single method, while food emulsifiers are detected directly without any dopant. All three atmospheric pressure ionization techniques (ESI, APCI and APPI) are compared for the metabolic analysis of Fusarium oxysporum using high-resolution LC–MS-MS and post-column addition of Ca2+ , Cu2+ or Zn2+ solutions. Emerging pollutants are screened in wastewaters using high-resolution MS and a home-made library of their mass spectra. New technical
developments are also published in the area of GC–MS coupling. The first study describes the development of four-stage-flow modulation comprehensive GC × GC–MS and the second paper reports on an interesting application of LC × GC–MS in the identification of Mycobacterium tuberculosis. The Web-of-Science citation analysis of previous seven volumes in the series of Mass spectrometry: Innovation and application showed that the following five articles have attracted the highest attention from the scientific community based on average citations per year (as of February 10, 2016) and they belong to 1% of most cited papers in Journal of Chromatography A in specific years: Signal suppression/enhancement in high-performance liquid chromatography tandem mass spectrometry (27.86 citations/year) [1], Analytical strategies for residue analysis of veterinary drugs and growthpromoting agents in food-producing animals (26.08 citations/year) [2], Liquid chromatography-tandem mass spectrometry for the analysis of pharmaceutical residues in environmental samples: a review (24.75 citations/year) [3], Matrix effect in LC-ESI-MS and LC-APCI-MS with off-line and on-line extraction procedures (16.92 citations/year) [4], and Recent developments in liquid chromatography-mass spectrometry and related techniques (14.80 citations/year) [5]. Finally, we would like to express our thanks to all people involved in the preparation of this special issue starting from authors as key contributors to this work, reviewers and also the journal staff providing valuable support. The forthcoming HPLC symposia organized this June in San Francisco [6] and the next year in Prague [7] will provide next opportunities to present the latest scientific contributions on separation techniques and mass spectrometry. The 9th issue in the series may be published in conjunction with the latter conference.
References [1] F. Gosetti, E. Mazzucco, D. Zampieri, M.C. Gennaro, Signal suppression/enhancement in high-performance liquid chromatography tandem mass spectrometry, J. Chromatogr. A 1217 (25) (2010) 3929–3937. [2] A.A.M. Stolker, U.A.T. Brinkman, Analytical strategies for residue analysis of veterinary drugs and growth-promoting agents in food-producing animals—a review, J. Chromatogr. A 1067 (1–2) (2005) 15–53. [3] M. Petrovic, M.D. Hernando, M.S. Diaz-Cruz, D. Barcelo, Liquid chromatography-tandem mass spectrometry for the analysis of pharmaceutical residues in environmental samples: a review, J. Chromatogr. A 1067 (2005) 1–14. [4] S. Souverain, S. Rudaz, J.L. Veuthey, Matrix effect in LC–ESI-MS and LC–APCI-MS with off-line and on-line extraction procedures, J. Chromatogr. A 1058 (2004) 61–66.
http://dx.doi.org/10.1016/j.chroma.2016.02.040 0021-9673/© 2016 Elsevier B.V. All rights reserved.
Please cite this article in press as: M. Holˇcapek, et al., Mass spectrometry: Innovation and application—Part VIII, J. Chromatogr. A (2016), http://dx.doi.org/10.1016/j.chroma.2016.02.040
G Model CHROMA-357314; No. of Pages 2 2
ARTICLE IN PRESS Foreword / J. Chromatogr. A xxx (2016) xxx–xxx
[5] M. Holˇcapek, R. Jirásko, M. Lísa, Recent developments in liquid chromatography–mass spectrometry and related techniques, J. Chromatogr. A 1259 (2012) 3–15. [6] http://hplc2016.org [7] http://www.hplc2017-prague.org
∗ Corresponding author. E-mail address: [email protected] (M. Holˇcapek)
Available online xxx M. Holˇcapek ∗ Pardubice, Czech Republic P.J. Schoenmakers Amsterdam, The Netherlands G. Hopfgartner Geneva, Switzerland
Please cite this article in press as: M. Holˇcapek, et al., Mass spectrometry: Innovation and application—Part VIII, J. Chromatogr. A (2016), http://dx.doi.org/10.1016/j.chroma.2016.02.040