- Email: [email protected]
Method for producing transgenic animal models with modulated phenotype and animals produced therefrom (K Duff and J Hardy, US)
l
les derniers brevets deposks rkalis6e en collaboration
Productions vfigktales z Proteins with enhanced levels of essential amino acids (AG Rao and KR Roesler, US)
Pioneer Hi-Bred International Inc and the inventors NOW0 98120133,
PCT.
The present invention provides for polypeptides comprising protease inhibitors with increased amounts of essential amino acids and nucleotides encoding for these peptides. Also provided are transformed plants and seeds with enhanced nutritional value due to the expression of modified polypeptidcs. > Heat stable mutants starch biosynthesis zymes (LC Hannah TW Greene, US)
of enand
University of Florida NOW0 98122601,
PCT.
The subject invention pertains to novel mufant polynucleotide molecules that encodes enzyme that increased heat stability. These polynucleotides, when expressed in plants, result in increased yield in plants grown under conditions of heat stress. (...)
Alimentation > Carrot peptides
antifreeze
poly-
Unilever plc N" 843010,EP.
Kovel antifreeze polypeptides can be isolated from carrots. These peptides can favourable influence the properties of consumer products eg frozen confectionery products. z Organometallic-metabolizing yeast (P Yang HS Hsia, US)
and
Viva America Marketing Inc NOW0 98/12925,PCT
The present invention includes a novel yeast strain of the genus Smxharonzyces hodardii sequela PY3 1 that is able to process certain metallic compounds into biologically active forms suitable for supplementing the human diet. The present in48 BIOFUTUR 181
l
Sedembre1998
vention also includes methods for isolating such yeast, nutritional supplement compositions containing such yeast, and methods of administering the nutritional supplcmenr conpositions to humans. z= Transformation and regeneration of fertile cotton plants (NL Trolinder et al, US)
South Plains Biotechnologies Inc and the inventors N"W0
: morceaux choisis avec I’lnpi
and FI generation by crossing a first and second tramgenie parent each carrying a different expressible transgene for differing aspects of the same desired phenotype associated with AI) pathology. The offsprings of the Fl generation arc then screened and those which carry a transgene from each parental transgenic animal resuiting in ‘III enhanced pathology for Alzheimer’s Disease are selected. (...I
l
mune response in the first transgenic animal yielding an antibody specific for an epitope peculiar to the second form of the polymorphic protein. (...i
> Oligomers which inhibit the expression of interleukin genes (D Veerapanane et al, US, JP)
Hisamitsu Pharmaceutical Co Inc NOW0 98118812,
98115622,PCT.
A method for i~z LJI‘LWrege-neration of fertile Goss)?-pin plants is provided in which cells from the trail-sition region tissue of seed-lings is excised and cultured. The transition region tissue of cotton seedlings extend from the uppermost portion of the root and into the hypocotyl region. Transformed cells are regenerated into homogeneously transformed plants by means of somatic embryogenesis on hormonefree medium. (...)
Pl~~tes > Method for tranforming lndica rice (Y Hiei, JP)
Japan Tobacco
Inc
N" WO 98117813,PCT.
A method by which Indic.1 rice can he efficiently transformed. In this method, inmature Indica rice germ cells are transformed by the Agrobacterium method and the resultant transformants are screened with the use of media (...)
Animaux transgeniques 5 Method for producing transgenic animal models with modulated phenotype and animals produced therefrom (K Duff and J Hardy, US)
University of South Florida and the inventors NOW0 98117782,PCT
A method of preparing a transgenic animal model with enhanced, accelerated pathology for Alzheimer”s Disease (AD) and the tramgenie animal made by the method are disclosed. The method includes producing
ProtQines Insulin homologs Conklin et al, US)
(DC
7
Zymogenetics
Inc
NOW0 98116635.
PCT.
The present invention relates to polynucleotide and polypeptide molecules for a novel insulin homolog. The polypeptides, and polynucleotides encoding them, have located to chromosome 12. The present invention also includes antibodies to the insulin homolog polypeptides.
PCT.
Oligomers for inhibiting expression of interleukin genes are dcscrihed. It is believed that each olipomer, when introduced into a cell, is capable of forming a transcription-inhibiting complex composed of the oligomcr and an mterleukin gene. The oligomer preferably binds in the antiparallel orientation to the polypurine strand of a polvpurine-polypyrimidine region of the interleukin gene.
z Novel probes for the detection of mycobacteria (HF Stender et al, DK)
Dako A/S NOW0 98115648,PCT.
Method of making monoclonal antibodies using polymorphic transgenic animals (ME Reid, US) 7
The New York Blood Center Inc N"WO98121316.
PCT.
The invention relates to a method for making monoclonal antibodies having pre-defined specificity of an epitope characteristic of or unique to a single form for a polymorphic protein. The method includes constructing a first transgenic animal to express a first form of a polymorphic protein encoded by a first allele of a gene encoding the protein ; constructing a second transgenie animal to express a second form of the polymorphic protein encoded by a second allele of the gene encoding the protein ; and immunizing the first transgenit animal with cells from the second transgenic animal expressing the second form of the polymorphic protein to induce an im-
Novel hybridisation assay probes and mixtures of such probes for detecting a target sequence of one or more mycohacteria optionally present in a sample. The probes may suitably be directed to target sequences of mycobacterial rDNA, precursor rRNA, or rRNA, said probes being capable of forming detectable hybrids. (...) Diagnosis encephalopathy linge, GB) 7
of spongiform (J Col-
Imperial College of Science, Technology and Medicine and the inventor NOW0 98/16834,PCT The present invention relates to a method for typing a sample of a prion or spongiform encephalopathy disease, a kit suitable for use in such a typing method, a method for identifying infection in an animal and/or tissue of bovine spongiform encephalopathy (BSE), a method for assessing and/or predicting the susceptibility
les derniers brevets deposks rkalis6e en collaboration
Productions vfigktales z Proteins with enhanced levels of essential amino acids (AG Rao and KR Roesler, US)
Pioneer Hi-Bred International Inc and the inventors NOW0 98120133,
PCT.
The present invention provides for polypeptides comprising protease inhibitors with increased amounts of essential amino acids and nucleotides encoding for these peptides. Also provided are transformed plants and seeds with enhanced nutritional value due to the expression of modified polypeptidcs. > Heat stable mutants starch biosynthesis zymes (LC Hannah TW Greene, US)
of enand
University of Florida NOW0 98122601,
PCT.
The subject invention pertains to novel mufant polynucleotide molecules that encodes enzyme that increased heat stability. These polynucleotides, when expressed in plants, result in increased yield in plants grown under conditions of heat stress. (...)
Alimentation > Carrot peptides
antifreeze
poly-
Unilever plc N" 843010,EP.
Kovel antifreeze polypeptides can be isolated from carrots. These peptides can favourable influence the properties of consumer products eg frozen confectionery products. z Organometallic-metabolizing yeast (P Yang HS Hsia, US)
and
Viva America Marketing Inc NOW0 98/12925,PCT
The present invention includes a novel yeast strain of the genus Smxharonzyces hodardii sequela PY3 1 that is able to process certain metallic compounds into biologically active forms suitable for supplementing the human diet. The present in48 BIOFUTUR 181
l
Sedembre1998
vention also includes methods for isolating such yeast, nutritional supplement compositions containing such yeast, and methods of administering the nutritional supplcmenr conpositions to humans. z= Transformation and regeneration of fertile cotton plants (NL Trolinder et al, US)
South Plains Biotechnologies Inc and the inventors N"W0
: morceaux choisis avec I’lnpi
and FI generation by crossing a first and second tramgenie parent each carrying a different expressible transgene for differing aspects of the same desired phenotype associated with AI) pathology. The offsprings of the Fl generation arc then screened and those which carry a transgene from each parental transgenic animal resuiting in ‘III enhanced pathology for Alzheimer’s Disease are selected. (...I
l
mune response in the first transgenic animal yielding an antibody specific for an epitope peculiar to the second form of the polymorphic protein. (...i
> Oligomers which inhibit the expression of interleukin genes (D Veerapanane et al, US, JP)
Hisamitsu Pharmaceutical Co Inc NOW0 98118812,
98115622,PCT.
A method for i~z LJI‘LWrege-neration of fertile Goss)?-pin plants is provided in which cells from the trail-sition region tissue of seed-lings is excised and cultured. The transition region tissue of cotton seedlings extend from the uppermost portion of the root and into the hypocotyl region. Transformed cells are regenerated into homogeneously transformed plants by means of somatic embryogenesis on hormonefree medium. (...)
Pl~~tes > Method for tranforming lndica rice (Y Hiei, JP)
Japan Tobacco
Inc
N" WO 98117813,PCT.
A method by which Indic.1 rice can he efficiently transformed. In this method, inmature Indica rice germ cells are transformed by the Agrobacterium method and the resultant transformants are screened with the use of media (...)
Animaux transgeniques 5 Method for producing transgenic animal models with modulated phenotype and animals produced therefrom (K Duff and J Hardy, US)
University of South Florida and the inventors NOW0 98117782,PCT
A method of preparing a transgenic animal model with enhanced, accelerated pathology for Alzheimer”s Disease (AD) and the tramgenie animal made by the method are disclosed. The method includes producing
ProtQines Insulin homologs Conklin et al, US)
(DC
7
Zymogenetics
Inc
NOW0 98116635.
PCT.
The present invention relates to polynucleotide and polypeptide molecules for a novel insulin homolog. The polypeptides, and polynucleotides encoding them, have located to chromosome 12. The present invention also includes antibodies to the insulin homolog polypeptides.
PCT.
Oligomers for inhibiting expression of interleukin genes are dcscrihed. It is believed that each olipomer, when introduced into a cell, is capable of forming a transcription-inhibiting complex composed of the oligomcr and an mterleukin gene. The oligomer preferably binds in the antiparallel orientation to the polypurine strand of a polvpurine-polypyrimidine region of the interleukin gene.
z Novel probes for the detection of mycobacteria (HF Stender et al, DK)
Dako A/S NOW0 98115648,PCT.
Method of making monoclonal antibodies using polymorphic transgenic animals (ME Reid, US) 7
The New York Blood Center Inc N"WO98121316.
PCT.
The invention relates to a method for making monoclonal antibodies having pre-defined specificity of an epitope characteristic of or unique to a single form for a polymorphic protein. The method includes constructing a first transgenic animal to express a first form of a polymorphic protein encoded by a first allele of a gene encoding the protein ; constructing a second transgenie animal to express a second form of the polymorphic protein encoded by a second allele of the gene encoding the protein ; and immunizing the first transgenit animal with cells from the second transgenic animal expressing the second form of the polymorphic protein to induce an im-
Novel hybridisation assay probes and mixtures of such probes for detecting a target sequence of one or more mycohacteria optionally present in a sample. The probes may suitably be directed to target sequences of mycobacterial rDNA, precursor rRNA, or rRNA, said probes being capable of forming detectable hybrids. (...) Diagnosis encephalopathy linge, GB) 7
of spongiform (J Col-
Imperial College of Science, Technology and Medicine and the inventor NOW0 98/16834,PCT The present invention relates to a method for typing a sample of a prion or spongiform encephalopathy disease, a kit suitable for use in such a typing method, a method for identifying infection in an animal and/or tissue of bovine spongiform encephalopathy (BSE), a method for assessing and/or predicting the susceptibility