- Email: [email protected]
Nomenclature for factors of the HLA system, update May 2015
Human Immunology 76 (2015) 600–603
Contents lists available at ScienceDirect
www.ashi-hla.org
journal homepage: www.elsevier.com/locate/humimm
Nomenclature for factors of the HLA system, update May 2015 Compiled by Steven G.E. Marsh ⇑ for the WHO Nomenclature Committee for Factors of the HLA System
The following sequences have been submitted to the Nomenclature Committee since the April 2015 nomenclature update and, following agreed policy, have been assigned official allele designations [1]. Full details of all sequences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the
sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The ‘Q’ suffix has been added to the DQA1*01:07 allele, which will now be known as DQA1*01:07Q. All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided [2]. The IMGT/HLA Database may be accessed via the World Wide Web at: www.ebi.ac.uk/ipd/imgt/hla.
Table 1 New sequences. HLA Allele
Cell identification
Accession number
Submitting author
A*01:01:70 A*02:06:01:02 A*03:223 A*03:224 A*03:225 A*11:218 A*24:309 A*24:310:01 A*26:01:01:02 A*26:115 A*29:02:17 A*31:01:02:03N A*68:43:02 B*07:256 B*14:47 B*15:360 B*15:361 B*15:362 B*35:289 B*35:290 B*35:291 B*35:292 B*38:01:09 B*39:105 B*40:02:24 B*40:307 B*42:02:01:02
RMC29714 11QB000147 DKMS-LSL-A-423 DKMS-LSL-A-428 CTM-5030893 DKMS-LSL-A-424 FI65999 JRC-D36-037 LUMC-A72b DKMS-LSL-A-427 DKMS-LSL-A-425 MDA0000168 DKMS-LSL-A-426 HG00010027 HG00010029 HG00010016 HG00010017 HG00010033 HG00010022 HG00010032 800140419 157820FMDA HG00010030 HG00010031 DURC JRC-D36-034 LUMC-A74
LN830754 JN384010 LN832584 LN832588 KR106299 LN832585 KR560053 LC055186 FR823454 LN832589 LN832586 KJ755682 LN832587 KP792226 KP711755 KP711761 KP792202 KP342348 KP792199 KP711760 LC051139 KR698076 KP711756 KP342349 HG530130 LC055187 FR823455
Maria Loginova, Kirov, Russia Janette Kwok, Pokfulam Road, Hong Kong DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany Antonio Balas, Madrid, Spain DKMS Life Science Lab, Dresden, Germany Michele Curcio, Pisa, Italy Kenji Tadokoro, Tokyo, Japan Jacqy DH Anholts, Leiden, The Netherlands DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany Kai Cao, Houston, USA DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Florent Delbos, Creteil, France Maria Elisa Moraes, Rio de Janeiro, Brazil Histogenetics, Ossining, USA Histogenetics, Ossining, USA Valerie Dubois, Lyon, France Kenji Tadokoro, Tokyo, Japan Jacqy DH Anholts, Leiden, The Netherlands
⇑ Address for correspondence: Professor Steven G.E. Marsh, Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom. E-mail address: [email protected] URLs: http://hla.alleles.org, http://www.anthonynolan.org/hig, http://www.ebi.ac.uk/ipd/imgt/hla http://dx.doi.org/10.1016/j.humimm.2015.07.005 0198-8859/Ó 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
601
S.G.E. Marsh / Human Immunology 76 (2015) 600–603 Table 1 (continued) HLA Allele
Cell identification
Accession number
Submitting author
B*42:21 B*44:221 B*48:04:02 B*50:43 B*51:190 B*52:50 B*53:01:11 B*54:01:07 B*56:48 B*58:01:19 C*01:02:36 C*01:110 C*02:102 C*02:103 C*02:104 C*02:105N
HG00010026 HG00010023 HG00010028 HG00010025 HG00006015 DKMS-LSL-B-419 HG00010021 SZ101040 HG00010020 93089917 DKMS-LSL-C-407 DKMS-LSL-C-404 DKMS-LSL-C-361 DKMS-LSL-C-395 HG00010067 91948_20USP, 91855_75USP, 91826_137USP DKMS-LSL-C-387 HG00010077 DKMS-LSL-C-389 DKMS-LSL-C-403 DKMS-LSL-C-418 HG00010075 HG00010076 HG00010078 0103076 JRC-D78-044 DKMS-LSL-C-407 DKMS-LSL-C-405 DKMS-LSL-C-390 DKMS-LSL-C-413 HG00010061 HG00010063 DKMS-LSL-C-391 HG00010036 HG00010037 HG00010058 DKMS-LSL-C-373 DKMS-LSL-C-401 DKMS-LSL-C-392 DKMS-LSL-C-393 DKMS-LSL-C-414 DKMS-LSL-C-417 HG00010035 HG00010038 HG00010039, HG00010040, HG00010041, HG00010042, HG00010043, HG00010044, HG00010045, HG00010046, HG00010047, HG00010048, HG00010049 HG00010050 HG00010051 HG00010052 HG00010054 HG00010055 HG00010056 HG00010057 15208709 HG00010062 UCLAXZ-0001 DKMS-LSL-C-415 HG00010064 HG00010065 HG00010066 41614 DKMS-LSL-C-409 DKMS-LSL-C-397 HG00010070, HG00010071, HG00010072 HG00010074 3738337328 DKMS-LSL-C-396 HG00010111 HG00010110 HG00010101 HG00010099 HG00010098
KP665943 KP711764 KP711759 KP342347 KC991062 LN832563 KP711763 HQ651232 KP665946 KP230537 LN811517 LN811515 LN811476 LN811507 KP711787 KR698080, KR698081, KR698082
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Jun He, Suzhou, China Histogenetics, Ossining, USA Daniel Fuerst, Ulm, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Maria Elisa Moraes, Rio de Janeiro, Brazil
LN811501 KP665948 LN811502 LN811514 LN811529 KP665950 KP342352 KP342355 KR560068 LC055188 LN811518 LN811516 LN811503 LN811525 KP325454 KP792228 LN811504 KP735530 KP711779 KP325455 LN827802 LN811513 LN811505 LN811531 LN811526 LN811533 KP792227 KP711776 KP711780, KP711784, KP792213, KP711783, KP342353 KP792230 KP792203 KP325458 KP711778 KP792205 KP792207 KR534595 KP325456 KR269771 LN811527 KP665949 KP665947 KP711786 HG327125 LN811520 LN811509 KP735533, KP711775 HE981740 LN811508 KP735537 KP711798 KP665958 KP325463 KP342366
DKMS Life Science Lab, Dresden, Histogenetics, Ossining, USA DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Chun-Ying Lin, Taipei, Taiwan Kenji Tadokoro, Tokyo, Japan DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, Histogenetics, Ossining, USA Histogenetics, Ossining, USA DKMS Life Science Lab, Dresden, Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
C*03:04:48 C*03:184:02 C*03:288 C*03:289 C*03:290 C*03:291 C*03:292 C*03:293 C*03:294 C*03:295 C*04:01:01:06 C*04:01:68 C*04:201 C*05:118 C*05:119 C*05:120 C*06:156 C*06:157 C*06:158 C*06:159 C*07:01:49 C*07:02:69 C*07:78:02 C*07:424 C*07:425 C*07:426 C*07:427 C*07:428 C*07:429
C*07:430 C*07:431 C*07:432 C*07:433 C*07:434 C*07:435 C*07:436 C*07:437N C*08:120 C*08:121N C*12:03:37 C*12:157 C*12:158 C*12:159 C*12:160 C*14:02:19 C*14:71 C*15:114 C*15:115N C*16:85 C*17:30 DRB1*01:02:11 DRB1*01:71 DRB1*03:120 DRB1*04:08:04 DRB1*04:53:02
KP792208, KP792212, KP711785, KP735532, KP711781, KP711782, KP735531
KP792209, KP735534
Germany Germany Germany Germany
Germany Germany Germany Germany
Germany
Germany Germany Germany Germany Germany Germany
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Daniel Fuerst, Ulm, Germany Histogenetics, Ossining, USA Xiaohai Zhang, Los Angeles, USA DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Marcel GJ Tilanus, Maastricht, The Netherlands DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Robert Collins, London, United Kingdom DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA (continued on next page)
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S.G.E. Marsh / Human Immunology 76 (2015) 600–603
Table 1 (continued) HLA Allele
Cell identification
Accession number
Submitting author
DRB1*07:01:18 DRB1*07:59 DRB1*07:60 DRB1*10:15 DRB1*11:03:02 DRB1*11:103:02 DRB1*12:58 DRB1*13:05:03 DRB1*13:203 DRB1*13:204 DRB1*14:162 DRB1*14:163 DRB1*15:124 DRB1*16:35 DRB1*16:36 DRB4*01:09 DQB1*03:183 DQB1*03:184 DQB1*03:185 DQB1*03:186 DQB1*05:93 DQB1*05:94 DQB1*06:176 DQB1*06:177 DQB1*06:178 DQB1*06:179N DQB1*06:180 DPB1*04:02:08 DPB1*348:01:02 DPB1*441:01 DPB1*442:01 DPB1*443:01 DPB1*444:01 DPB1*445:01 DPB1*446:01 DPB1*447:01 DPB1*448:01 DPB1*449:01 DPB1*450:01N
150234_MMRP, 148907_MHDMB HG00010096 HG00010097 HG00010100 HG00010108 HG00010107 HG00009768 HG00010109 HG00009776 256801 HG00010102 HG00010103, HG00010104 HG00010095 HG00010094 WP47 LUMC-DRB4-100 HG00010083 HG00010085 HG00010087 93099719 HG00010082 HG00010088 HG00010080 HG00010081 HG00010091 HG00010092, HG00010093 15208356 HG00010117 HG00010122 HG00010112 HG00010113 HG00010115 HG00010116 HG00010118 HG00010119 HG00010120 HG00010123 HG00010125 HG00010124
KR698077, KR698078 KP342368 KP711801 KP665960 KP665959 KP342367 KM670542, KM670551 KP342365 KM670543, KM670550 KR138378 KP792216 KP792218, KP792219 KP792217 KP711799 KR131864 LN849724 KP735536 KP342360 KP711795 KR534593 KP711792 KP711790 KP792231 KP665952 KP735535 KP325459, KP325460 KR534592 KP342375 KP792222 KP665969 KP711807 KP792221 KP665968 KP711805 KP665964 KP342371 KP711804 KP665966 KP711802
Maria Elisa Moraes, Rio de Janeiro, Brazil Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Raquel Fabreti, Belo Horizonte, Brazil Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Wu Jiang Dong, Shihezi, China Jacqy DH Anholts, Leiden, The Netherlands Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Daniel Fuerst, Ulm, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Daniel Fuerst, Ulm, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
Table 2 Confirmatory sequences. HLA Allele
Cell identification
Accession number
Submitting author
B*08:56:02 C*01:107 C*02:05:03 C*02:35 C*02:69 C*02:87 C*03:192 C*03:251 C*04:42:02 C*06:142 C*07:172:02 C*07:371 C*08:103 C*12:03:29 C*14:02:12 DRB1*03:112 DRB1*13:45 DRB1*15:112 DQA1*01:07Q DQB1*03:02:16 DQB1*03:105
DKMS-LSL-B-420 HG00010034 HG00010068 DKMS-LSL-C-411 24922955 DKMS-LSL-C-416 DKMS-LSL-C-412 DKMS-LSL-C-399 DKMS-LSL-C-400 DKMS-LSL-C-394 DKMS-LSL-C-388 DKMS-LSL-C-402 DKMS-LSL-C-408 DKMS-LSL-C-398 DKMS-LSL-C-410 70449 HG00009781 16240383 KMP 70417 148035_SDCFG
LN832564 KP792210 KP342356 LN811523 LN833885 LN811528 LN811524 LN811511 LN811512 LN811506 LN811530 LN811532 LN811519 LN811510 LN811522 LN846903 KM670544, KM670549 LN846904 FN796494 LN846902 KR698079
DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA DKMS Life Science Lab, Dresden, Germany Thibaut Gervais, Brussels, Belgium DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany Jane Rowlands, Pontyclun, United Kingdom Histogenetics, Ossining, USA Jane Rowlands, Pontyclun, United Kingdom Bouke Hepkema, Groningen, The Netherlands Jane Rowlands, Pontyclun, United Kingdom Maria Elisa Moraes, Rio de Janeiro, Brazil
S.G.E. Marsh / Human Immunology 76 (2015) 600–603 Table 3 Recently published sequences. HLA Allele
References
A*02:455 A*02:548 A*31:01:02:02 B*15:01:37 B*15:263 B*15:327 B*44:220 B*58:63 C*01:02:34 C*15:02:21 DRB1*10:07 DRB1*15:115N DQB1*03:03:08 DQB1*03:03:13
[3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [15]
References [1] Marsh SGE, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Fernandez-Vina M, Geraghty DE, Holdsworth R, Hurley CK, Lau M, Lee KW, Mach B, Maiers M, Mayr WR, Muller CR, Parham P, Petersdorf EW, Sasazuki T, Strominger JL, Svejgaard A, Terasaki PI, Tiercy JM, Trowsdale J. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010;75(4):291–455. [2] Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015;43:D423–31.
603
[3] Crijns VB, Groeneweg M, Schouten HC, Voorter CE, Tilanus MG. Features of a new full length HLA allele: A⁄02:455. Tissue Antigens 2015;86(1):53–5. [4] Cappuzzo V, Ingrassia F, Bavetta R, Mistretta S, Marceno R. Characterization of a new HLA allele: A⁄02:548. Tissue Antigens 2015;86(1):55–6. [5] Balas A, Garcia-Sanchez F, Vicario JL. HLA-A allele dropout in sequence-specific oligonucleotide probe typing due to intronic polymorphism in the novel A*31:01:02:02 allele. Tissue Antigens 2015;86(1):56–7. [6] Yang KL, Hung JH, Lin PY. Detection of a novel HLA-B*15 variant, HLAB*15:01:37, in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens 2015;86(1):57–8. [7] Park BG, Park Y, Yoon CE, Kwon OJ, Kim HS. A new HLA-B*15 allele, HLAB*15:263, identified in a Korean individual. Tissue Antigens 2015;86(1):58–9. [8] Yang KL, Lee SK, Hung JH, Lin PY. HLA-B*15:327, a novel variant of HLA-B*15, discovered in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens 2015;86(1):60–1. [9] Hayward DR, Bultitude WP, Mayor NP, Madrigal JA, Marsh SGE. The novel HLAB*44 allele, HLA-B*44:220, identified by Single Molecule Real-Time DNA sequencing in a British Caucasoid male. Tissue Antigens 2015;86(1):61–3. [10] Ji X, Wang J, Ou GJ, Wang CY, Liu Z. HLA-B*58:63, a novel allele identified by sequence-based typing in a Chinese bone marrow voluntary donor. Tissue Antigens 2015;85(1):73–5. [11] Yang KL, Hung JH, Lin PY. A single nucleotide replacement in exon 2 produces a novel HLA-C*01:02 variant, HLA-C*01:02:34. Tissue Antigens 2015;86(1): 63–5. [12] Huo MR, Yu Y, Xi B, Li D. Identification of a novel HLA-C*15 allele, HLAC*15:02:21. Tissue Antigens 2015;86(1):65–6. [13] He JJ, Zhang W, Wang W, He J, Zhu FM, Lv HJ. A novel allele, HLA-DRB1*10:07 was identified in a Chinese individual. Tissue Antigens 2015;86(1):68–9. [14] Li X, Zou H, Li M, Chen Q. A novel null HLA allele, HLA-DRB1*15:115N, identified in a Chinese family. Tissue Antigens 2015;86(1):69–70. [15] Zhang W, Wang W, Han ZD, He JJ, He J, Zhu FM, Lv HJ. Two novel HLADQB1*03:03 alleles, HLA-DQB1*03:03:08 and DQB1*03:03:13, were identified in Chinese individuals. Tissue Antigens 2015;86(1):66–8.
Contents lists available at ScienceDirect
www.ashi-hla.org
journal homepage: www.elsevier.com/locate/humimm
Nomenclature for factors of the HLA system, update May 2015 Compiled by Steven G.E. Marsh ⇑ for the WHO Nomenclature Committee for Factors of the HLA System
The following sequences have been submitted to the Nomenclature Committee since the April 2015 nomenclature update and, following agreed policy, have been assigned official allele designations [1]. Full details of all sequences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the
sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The ‘Q’ suffix has been added to the DQA1*01:07 allele, which will now be known as DQA1*01:07Q. All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided [2]. The IMGT/HLA Database may be accessed via the World Wide Web at: www.ebi.ac.uk/ipd/imgt/hla.
Table 1 New sequences. HLA Allele
Cell identification
Accession number
Submitting author
A*01:01:70 A*02:06:01:02 A*03:223 A*03:224 A*03:225 A*11:218 A*24:309 A*24:310:01 A*26:01:01:02 A*26:115 A*29:02:17 A*31:01:02:03N A*68:43:02 B*07:256 B*14:47 B*15:360 B*15:361 B*15:362 B*35:289 B*35:290 B*35:291 B*35:292 B*38:01:09 B*39:105 B*40:02:24 B*40:307 B*42:02:01:02
RMC29714 11QB000147 DKMS-LSL-A-423 DKMS-LSL-A-428 CTM-5030893 DKMS-LSL-A-424 FI65999 JRC-D36-037 LUMC-A72b DKMS-LSL-A-427 DKMS-LSL-A-425 MDA0000168 DKMS-LSL-A-426 HG00010027 HG00010029 HG00010016 HG00010017 HG00010033 HG00010022 HG00010032 800140419 157820FMDA HG00010030 HG00010031 DURC JRC-D36-034 LUMC-A74
LN830754 JN384010 LN832584 LN832588 KR106299 LN832585 KR560053 LC055186 FR823454 LN832589 LN832586 KJ755682 LN832587 KP792226 KP711755 KP711761 KP792202 KP342348 KP792199 KP711760 LC051139 KR698076 KP711756 KP342349 HG530130 LC055187 FR823455
Maria Loginova, Kirov, Russia Janette Kwok, Pokfulam Road, Hong Kong DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany Antonio Balas, Madrid, Spain DKMS Life Science Lab, Dresden, Germany Michele Curcio, Pisa, Italy Kenji Tadokoro, Tokyo, Japan Jacqy DH Anholts, Leiden, The Netherlands DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany Kai Cao, Houston, USA DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Florent Delbos, Creteil, France Maria Elisa Moraes, Rio de Janeiro, Brazil Histogenetics, Ossining, USA Histogenetics, Ossining, USA Valerie Dubois, Lyon, France Kenji Tadokoro, Tokyo, Japan Jacqy DH Anholts, Leiden, The Netherlands
⇑ Address for correspondence: Professor Steven G.E. Marsh, Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom. E-mail address: [email protected] URLs: http://hla.alleles.org, http://www.anthonynolan.org/hig, http://www.ebi.ac.uk/ipd/imgt/hla http://dx.doi.org/10.1016/j.humimm.2015.07.005 0198-8859/Ó 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
601
S.G.E. Marsh / Human Immunology 76 (2015) 600–603 Table 1 (continued) HLA Allele
Cell identification
Accession number
Submitting author
B*42:21 B*44:221 B*48:04:02 B*50:43 B*51:190 B*52:50 B*53:01:11 B*54:01:07 B*56:48 B*58:01:19 C*01:02:36 C*01:110 C*02:102 C*02:103 C*02:104 C*02:105N
HG00010026 HG00010023 HG00010028 HG00010025 HG00006015 DKMS-LSL-B-419 HG00010021 SZ101040 HG00010020 93089917 DKMS-LSL-C-407 DKMS-LSL-C-404 DKMS-LSL-C-361 DKMS-LSL-C-395 HG00010067 91948_20USP, 91855_75USP, 91826_137USP DKMS-LSL-C-387 HG00010077 DKMS-LSL-C-389 DKMS-LSL-C-403 DKMS-LSL-C-418 HG00010075 HG00010076 HG00010078 0103076 JRC-D78-044 DKMS-LSL-C-407 DKMS-LSL-C-405 DKMS-LSL-C-390 DKMS-LSL-C-413 HG00010061 HG00010063 DKMS-LSL-C-391 HG00010036 HG00010037 HG00010058 DKMS-LSL-C-373 DKMS-LSL-C-401 DKMS-LSL-C-392 DKMS-LSL-C-393 DKMS-LSL-C-414 DKMS-LSL-C-417 HG00010035 HG00010038 HG00010039, HG00010040, HG00010041, HG00010042, HG00010043, HG00010044, HG00010045, HG00010046, HG00010047, HG00010048, HG00010049 HG00010050 HG00010051 HG00010052 HG00010054 HG00010055 HG00010056 HG00010057 15208709 HG00010062 UCLAXZ-0001 DKMS-LSL-C-415 HG00010064 HG00010065 HG00010066 41614 DKMS-LSL-C-409 DKMS-LSL-C-397 HG00010070, HG00010071, HG00010072 HG00010074 3738337328 DKMS-LSL-C-396 HG00010111 HG00010110 HG00010101 HG00010099 HG00010098
KP665943 KP711764 KP711759 KP342347 KC991062 LN832563 KP711763 HQ651232 KP665946 KP230537 LN811517 LN811515 LN811476 LN811507 KP711787 KR698080, KR698081, KR698082
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Jun He, Suzhou, China Histogenetics, Ossining, USA Daniel Fuerst, Ulm, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Maria Elisa Moraes, Rio de Janeiro, Brazil
LN811501 KP665948 LN811502 LN811514 LN811529 KP665950 KP342352 KP342355 KR560068 LC055188 LN811518 LN811516 LN811503 LN811525 KP325454 KP792228 LN811504 KP735530 KP711779 KP325455 LN827802 LN811513 LN811505 LN811531 LN811526 LN811533 KP792227 KP711776 KP711780, KP711784, KP792213, KP711783, KP342353 KP792230 KP792203 KP325458 KP711778 KP792205 KP792207 KR534595 KP325456 KR269771 LN811527 KP665949 KP665947 KP711786 HG327125 LN811520 LN811509 KP735533, KP711775 HE981740 LN811508 KP735537 KP711798 KP665958 KP325463 KP342366
DKMS Life Science Lab, Dresden, Histogenetics, Ossining, USA DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Chun-Ying Lin, Taipei, Taiwan Kenji Tadokoro, Tokyo, Japan DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, Histogenetics, Ossining, USA Histogenetics, Ossining, USA DKMS Life Science Lab, Dresden, Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, DKMS Life Science Lab, Dresden, Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
C*03:04:48 C*03:184:02 C*03:288 C*03:289 C*03:290 C*03:291 C*03:292 C*03:293 C*03:294 C*03:295 C*04:01:01:06 C*04:01:68 C*04:201 C*05:118 C*05:119 C*05:120 C*06:156 C*06:157 C*06:158 C*06:159 C*07:01:49 C*07:02:69 C*07:78:02 C*07:424 C*07:425 C*07:426 C*07:427 C*07:428 C*07:429
C*07:430 C*07:431 C*07:432 C*07:433 C*07:434 C*07:435 C*07:436 C*07:437N C*08:120 C*08:121N C*12:03:37 C*12:157 C*12:158 C*12:159 C*12:160 C*14:02:19 C*14:71 C*15:114 C*15:115N C*16:85 C*17:30 DRB1*01:02:11 DRB1*01:71 DRB1*03:120 DRB1*04:08:04 DRB1*04:53:02
KP792208, KP792212, KP711785, KP735532, KP711781, KP711782, KP735531
KP792209, KP735534
Germany Germany Germany Germany
Germany Germany Germany Germany
Germany
Germany Germany Germany Germany Germany Germany
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Daniel Fuerst, Ulm, Germany Histogenetics, Ossining, USA Xiaohai Zhang, Los Angeles, USA DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Marcel GJ Tilanus, Maastricht, The Netherlands DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Robert Collins, London, United Kingdom DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA (continued on next page)
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S.G.E. Marsh / Human Immunology 76 (2015) 600–603
Table 1 (continued) HLA Allele
Cell identification
Accession number
Submitting author
DRB1*07:01:18 DRB1*07:59 DRB1*07:60 DRB1*10:15 DRB1*11:03:02 DRB1*11:103:02 DRB1*12:58 DRB1*13:05:03 DRB1*13:203 DRB1*13:204 DRB1*14:162 DRB1*14:163 DRB1*15:124 DRB1*16:35 DRB1*16:36 DRB4*01:09 DQB1*03:183 DQB1*03:184 DQB1*03:185 DQB1*03:186 DQB1*05:93 DQB1*05:94 DQB1*06:176 DQB1*06:177 DQB1*06:178 DQB1*06:179N DQB1*06:180 DPB1*04:02:08 DPB1*348:01:02 DPB1*441:01 DPB1*442:01 DPB1*443:01 DPB1*444:01 DPB1*445:01 DPB1*446:01 DPB1*447:01 DPB1*448:01 DPB1*449:01 DPB1*450:01N
150234_MMRP, 148907_MHDMB HG00010096 HG00010097 HG00010100 HG00010108 HG00010107 HG00009768 HG00010109 HG00009776 256801 HG00010102 HG00010103, HG00010104 HG00010095 HG00010094 WP47 LUMC-DRB4-100 HG00010083 HG00010085 HG00010087 93099719 HG00010082 HG00010088 HG00010080 HG00010081 HG00010091 HG00010092, HG00010093 15208356 HG00010117 HG00010122 HG00010112 HG00010113 HG00010115 HG00010116 HG00010118 HG00010119 HG00010120 HG00010123 HG00010125 HG00010124
KR698077, KR698078 KP342368 KP711801 KP665960 KP665959 KP342367 KM670542, KM670551 KP342365 KM670543, KM670550 KR138378 KP792216 KP792218, KP792219 KP792217 KP711799 KR131864 LN849724 KP735536 KP342360 KP711795 KR534593 KP711792 KP711790 KP792231 KP665952 KP735535 KP325459, KP325460 KR534592 KP342375 KP792222 KP665969 KP711807 KP792221 KP665968 KP711805 KP665964 KP342371 KP711804 KP665966 KP711802
Maria Elisa Moraes, Rio de Janeiro, Brazil Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Raquel Fabreti, Belo Horizonte, Brazil Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Wu Jiang Dong, Shihezi, China Jacqy DH Anholts, Leiden, The Netherlands Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Daniel Fuerst, Ulm, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Daniel Fuerst, Ulm, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
Table 2 Confirmatory sequences. HLA Allele
Cell identification
Accession number
Submitting author
B*08:56:02 C*01:107 C*02:05:03 C*02:35 C*02:69 C*02:87 C*03:192 C*03:251 C*04:42:02 C*06:142 C*07:172:02 C*07:371 C*08:103 C*12:03:29 C*14:02:12 DRB1*03:112 DRB1*13:45 DRB1*15:112 DQA1*01:07Q DQB1*03:02:16 DQB1*03:105
DKMS-LSL-B-420 HG00010034 HG00010068 DKMS-LSL-C-411 24922955 DKMS-LSL-C-416 DKMS-LSL-C-412 DKMS-LSL-C-399 DKMS-LSL-C-400 DKMS-LSL-C-394 DKMS-LSL-C-388 DKMS-LSL-C-402 DKMS-LSL-C-408 DKMS-LSL-C-398 DKMS-LSL-C-410 70449 HG00009781 16240383 KMP 70417 148035_SDCFG
LN832564 KP792210 KP342356 LN811523 LN833885 LN811528 LN811524 LN811511 LN811512 LN811506 LN811530 LN811532 LN811519 LN811510 LN811522 LN846903 KM670544, KM670549 LN846904 FN796494 LN846902 KR698079
DKMS Life Science Lab, Dresden, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA DKMS Life Science Lab, Dresden, Germany Thibaut Gervais, Brussels, Belgium DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany DKMS Life Science Lab, Dresden, Germany Jane Rowlands, Pontyclun, United Kingdom Histogenetics, Ossining, USA Jane Rowlands, Pontyclun, United Kingdom Bouke Hepkema, Groningen, The Netherlands Jane Rowlands, Pontyclun, United Kingdom Maria Elisa Moraes, Rio de Janeiro, Brazil
S.G.E. Marsh / Human Immunology 76 (2015) 600–603 Table 3 Recently published sequences. HLA Allele
References
A*02:455 A*02:548 A*31:01:02:02 B*15:01:37 B*15:263 B*15:327 B*44:220 B*58:63 C*01:02:34 C*15:02:21 DRB1*10:07 DRB1*15:115N DQB1*03:03:08 DQB1*03:03:13
[3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [15]
References [1] Marsh SGE, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Fernandez-Vina M, Geraghty DE, Holdsworth R, Hurley CK, Lau M, Lee KW, Mach B, Maiers M, Mayr WR, Muller CR, Parham P, Petersdorf EW, Sasazuki T, Strominger JL, Svejgaard A, Terasaki PI, Tiercy JM, Trowsdale J. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010;75(4):291–455. [2] Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015;43:D423–31.
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[3] Crijns VB, Groeneweg M, Schouten HC, Voorter CE, Tilanus MG. Features of a new full length HLA allele: A⁄02:455. Tissue Antigens 2015;86(1):53–5. [4] Cappuzzo V, Ingrassia F, Bavetta R, Mistretta S, Marceno R. Characterization of a new HLA allele: A⁄02:548. Tissue Antigens 2015;86(1):55–6. [5] Balas A, Garcia-Sanchez F, Vicario JL. HLA-A allele dropout in sequence-specific oligonucleotide probe typing due to intronic polymorphism in the novel A*31:01:02:02 allele. Tissue Antigens 2015;86(1):56–7. [6] Yang KL, Hung JH, Lin PY. Detection of a novel HLA-B*15 variant, HLAB*15:01:37, in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens 2015;86(1):57–8. [7] Park BG, Park Y, Yoon CE, Kwon OJ, Kim HS. A new HLA-B*15 allele, HLAB*15:263, identified in a Korean individual. Tissue Antigens 2015;86(1):58–9. [8] Yang KL, Lee SK, Hung JH, Lin PY. HLA-B*15:327, a novel variant of HLA-B*15, discovered in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens 2015;86(1):60–1. [9] Hayward DR, Bultitude WP, Mayor NP, Madrigal JA, Marsh SGE. The novel HLAB*44 allele, HLA-B*44:220, identified by Single Molecule Real-Time DNA sequencing in a British Caucasoid male. Tissue Antigens 2015;86(1):61–3. [10] Ji X, Wang J, Ou GJ, Wang CY, Liu Z. HLA-B*58:63, a novel allele identified by sequence-based typing in a Chinese bone marrow voluntary donor. Tissue Antigens 2015;85(1):73–5. [11] Yang KL, Hung JH, Lin PY. A single nucleotide replacement in exon 2 produces a novel HLA-C*01:02 variant, HLA-C*01:02:34. Tissue Antigens 2015;86(1): 63–5. [12] Huo MR, Yu Y, Xi B, Li D. Identification of a novel HLA-C*15 allele, HLAC*15:02:21. Tissue Antigens 2015;86(1):65–6. [13] He JJ, Zhang W, Wang W, He J, Zhu FM, Lv HJ. A novel allele, HLA-DRB1*10:07 was identified in a Chinese individual. Tissue Antigens 2015;86(1):68–9. [14] Li X, Zou H, Li M, Chen Q. A novel null HLA allele, HLA-DRB1*15:115N, identified in a Chinese family. Tissue Antigens 2015;86(1):69–70. [15] Zhang W, Wang W, Han ZD, He JJ, He J, Zhu FM, Lv HJ. Two novel HLADQB1*03:03 alleles, HLA-DQB1*03:03:08 and DQB1*03:03:13, were identified in Chinese individuals. Tissue Antigens 2015;86(1):66–8.