- Email: [email protected]
Note from the Editors
ABB Archives of Biochemistry and Biophysics 409 (2003) 1 www.elsevier.com/locate/yabbi
Note from the Editors Pioneering developments can create a home for future publications, a cluster of scientists publishing there subsequent to a seminal observation. Archives of Biochemistry and Biophysics has been the home of the field of cytochrome P450 from the very beginning. The discovery of this cytochrome came about in Philadelphia at the Johnson Research Foundation when two young scientists, Martin Klingenberg and David Garfinkel, were characterizing heme pigments in rat liver microsomes, using spectrophotometric methods: in 1958, the discovery of a cytochrome binding carbon monoxide in its reduced form, characterized by an absorption peak at 450 nm, was published (M. Klingenberg, (1958) Pigments of rat liver microsomes. Arch. Biochem. Biophys. 75, 376–386; D. Garfinkel, (1958) Studies on pig liver microsomes. I. Enzymatic and pigment composition of different microsomal fractions. Arch. Biochem. Biophys. 77, 493–509). Also at the Johnson Foundation at that time, Ronald W. Estabrook laid the basis for the fulminating developments in the field of monooxygenases, with other pioneers such as David Cooper and Otto Rosenthal. Ron Estabrook has published many of his papers in this journal, and indeed served as the Executive Editor for ABB from 1984 to 1990. (Knowing what this means, he deserves a special thanks from the undersigned.) His pioneering contributions to the field are presented in this issue by another giant in P450 research, M.F. Coon. As Editors, we here express our words of thanks first to Ron, as he is congenially called throughout the globe, for his scientific contributions to the CYP world and for his generosity in furthering interest and generating enthusiasm notably to young people entering this scientific field; second, of course, to all the authors contributing to this highlight issue in the form of cutting-edge minireviews or as original work; and third, to the reviewers and to Kristen Merritt from ABB who helped maintain quality and timing. We hope this Highlight Issue on Cytochrome P450, dedicated to Professor Ron Estabrook, will serve to generate further interest in this area of research and enlarge its scope. Mike Waterman and Helmut Sies
0003-9861/02/$ - see front matter Ó 2002 Elsevier Science (USA). All rights reserved. PII: S 0 0 0 3 - 9 8 6 1 ( 0 2 ) 0 0 5 9 3 - 3
Note from the Editors Pioneering developments can create a home for future publications, a cluster of scientists publishing there subsequent to a seminal observation. Archives of Biochemistry and Biophysics has been the home of the field of cytochrome P450 from the very beginning. The discovery of this cytochrome came about in Philadelphia at the Johnson Research Foundation when two young scientists, Martin Klingenberg and David Garfinkel, were characterizing heme pigments in rat liver microsomes, using spectrophotometric methods: in 1958, the discovery of a cytochrome binding carbon monoxide in its reduced form, characterized by an absorption peak at 450 nm, was published (M. Klingenberg, (1958) Pigments of rat liver microsomes. Arch. Biochem. Biophys. 75, 376–386; D. Garfinkel, (1958) Studies on pig liver microsomes. I. Enzymatic and pigment composition of different microsomal fractions. Arch. Biochem. Biophys. 77, 493–509). Also at the Johnson Foundation at that time, Ronald W. Estabrook laid the basis for the fulminating developments in the field of monooxygenases, with other pioneers such as David Cooper and Otto Rosenthal. Ron Estabrook has published many of his papers in this journal, and indeed served as the Executive Editor for ABB from 1984 to 1990. (Knowing what this means, he deserves a special thanks from the undersigned.) His pioneering contributions to the field are presented in this issue by another giant in P450 research, M.F. Coon. As Editors, we here express our words of thanks first to Ron, as he is congenially called throughout the globe, for his scientific contributions to the CYP world and for his generosity in furthering interest and generating enthusiasm notably to young people entering this scientific field; second, of course, to all the authors contributing to this highlight issue in the form of cutting-edge minireviews or as original work; and third, to the reviewers and to Kristen Merritt from ABB who helped maintain quality and timing. We hope this Highlight Issue on Cytochrome P450, dedicated to Professor Ron Estabrook, will serve to generate further interest in this area of research and enlarge its scope. Mike Waterman and Helmut Sies
0003-9861/02/$ - see front matter Ó 2002 Elsevier Science (USA). All rights reserved. PII: S 0 0 0 3 - 9 8 6 1 ( 0 2 ) 0 0 5 9 3 - 3