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OSTEOCLASTOGENIC POTENTIAL OF ORAL CARCINOMA CELLS CAN BE MODULATED BY LOW LEVEL LASER (LLL)
ORAL AND MAXILLOFACIAL PATHOLOGY e150 Abstracts This specialized center is an auxiliary unit of the university founded in 1991, which in the main activity carried out is the treatment of cancer patients. In addition, it integrates health professionals, undergraduates in researching and interdisciplinary care; knowledge exchange and mutual professional complementation. The aim of this study is to present a 6-year experience of activities in a Brazilian specialized center in the multidisciplinary treatment of head and neck cancer patients. Study Design: A retrospective analysis of data was performed through this service reports referring to services performed in the last 6 years, between 2010 and 2015. The results showed an annual average of 1114.8 oncologic examinations; 44.3 oncologic surgery; 1327.6 dental care; 1652.5 dental procedures; 1371.5 nursing assistances; 701.1 speech therapy; 548.8 physiotherapy care; 359.6 psychological assistance and 69.3 new cancer cases received in this period. The center acts performing diagnosis, treatment and rehabilitation of cancer patients in the city and the whole region, expanding the number and types of service over the last 6 years. Financial support: Pró-Reitoria de Extensão Universitária (PROEX) e UNESP.
RP122 - RISK FACTORS IN LARYNGECTOMIZED PATIENTS WITH PHARYNGOCUTANEOUS FISTULA. JANAÍNA ZAVITOSKI DA SILVA, ANNE CRISTINA DE FARIA COCATO, DANIELA BRITO BASTOS, INGRID DA SILVA SANTOS, ÉDER RICARDO BIASOLI, GLAUCO ISSAMU MIYAHARA, JOÃO JÚNIOR GOMES. The most common complication associated with the total laryngectomy is the appearance of fistula pharyngocutaneous, manifested in the first days after surgery and influencing the outcome of therapeutic evolution among laryngectomized patients. The aim of this research was to identify the risk factors that contribute to the formation of pharyngocutaneous fistula in patients submitted to the total laryngectomy surgery in a specialized center in the multidisciplinary treatment of head and neck cancer. A retrospective analysis of data was performed through this service reports referring to services performed since 1991 until 2012. There were found 81 patients; regarding gender, race, age, comorbidities, clinical stage, primary tumor site, previous tracheotomy, previous radiotherapy, weight/ height, time of appearance of the fistula, type of cervical dissection and survival; none showed statistical significance for fistula according to the chi-square test or Fisher exact test when applicable, considering P <.05 significant. It was concluded that the association of risk factors carry more significant role in the appearance of the fistula rather than a single factor. The early identification of the risk factors is extremely important for the planning of interventions to ensure intensive care and laryngeal cancer patients’ rights.
RP123 - THE POTENTIAL ROLE OF FAMILY HEALTH STRATEGY ON PROVIDE INFORMATION ABOUT PEOPLE AT RISK FOR ORAL CANCER. MAIANE NASCIMENTO, THAIS GONÇALES DOS SANTOS ANDRADE, PAULA SENA DA MATA, CLAUDIA YUMI MAEDA, PRISCILA SANTANA DA SILVA, FERNANDINA ALVES MOREIRA, DESIREE ROSA CAVALCANTI. Family Health Strategy (FHS) is a Brazilian program proposed to reorient health care model by multiprofessional teams. The Community Health Agents (CHA) plays a key role in the program and can provide these teams with information about people at risk for oral cancer.
OOOO August 2017 Objective: To obtain the prevalence and the localization of tobacco and alcohol consumers with information provided by CHA. Study Design: The data about habits by gender and age were collected in a Brazilian community served by FHS. The addresses of people with habits were registered. Results: A total of 4047 people were mapped (1952 males, 2095 females patients), being 2530 over 40 years (1199 males, 1331 females); 228 people (5.6%) were identified as tobacco consumers (151 males; 75 females) and 71 people (1.75%) as alcohol consumers (64 males; 7 females). For males over 40 years, the prevalence for tobacco was 10.4% and for alcohol 5.1%. Conclusion: The information provided by CHA was appropriate and allowed to calculate the prevalence of habits and the localization of these people in the community. The information is being used in a target model of oral screening and to follow the people at risk.
RP124 - BONE TRABECULAE: MARROW AND FIBROUS: CARTILAGINOUS LAYERS RATIO ARE AGE- BUT NOT GENDER-RELATED IN CONDYLAR HYPERPLASIA. FABIO RAMOA PIRES, NATÁLIA SANTOS CARNEIRO, TERESA CRISTINA RIBEIRO BARTHOLOMEU DOS SANTOS. Condylar hyperplasia is a developmental disorder characterized by enlargement of the mandibular condyle leading to abnormal bone growth and maxillofacial disturbances. Very little information is available on the histologic features that characterize the condition and the gender- and age-related differences. Objective: To compare the distribution of bone trabeculae:bone marrow and fibrous:cartilaginous layers in condylar hyperplasias according to the age and gender of the affected patients. Study Design: 30 condylar hyperplasias were selected and the mean ratio of bone trabeculae:bone marrow and fibrous:cartilaginous layers were calculated after analyzing 5 high power fields from each slide; values were compared by age and gender of the affected patients. Results: Sample included 19 females and 11 males (mean age 22 years, range 14-37). There were no female:male differences when comparing mean age of patients (P¼.258), bone trabeculae:bone marrow ratio (P¼.927) and fibrous:cartilaginous layers ratio (P¼.067). The correlation of age of the affected patients and bone trabeculae:bone marrow ratio (P¼.01) and fibrous:cartilaginous layers ratio (P¼.009) were both statistically significant. Conclusion: Bone trabeculae:bone marrow ratio and fibrous:cartilaginous layers ratio do not depend on gender but are associated with age of the affected patients by condylar hyperplasia. The authors thank FAPERJ for the financial support for the study.
RP125 - OSTEOCLASTOGENIC POTENTIAL OF ORAL CARCINOMA CELLS CAN BE MODULATED BY LOW LEVEL LASER (LLL). KRISTIANNE PORTA SANTOS FERNANDES, TATIANA DIAS SCHALCH, JOÃO COSTA-RODRIGUES, MÔNICA PEREIRA GARCIA, RAQUEL AGNELLI MESQUITAFERRARI, SANDRA KALLIL BUSSADORI, MARIA HELENA FERNANDES.
OOOO Volume 124, Number 2 This study aimed to analyze the effect of low-level laser on the osteoclastogenic potential of a squamous cell carcinoma cell line (SCC9). Irradiated SCC9 cells (660 /780 nm; 40 /70 mW; 2, 4 and 6 J/cm2) were cultured with human osteoclast precursors (PBMC). Co-cultures with non-irradiated SCC9 cells served as control. After 7, 14 and 21 days, the co-cultures (treated or not with specific inhibitors of MEK, NFkB, p38 and JNK pathways) were evaluated for the tartrate-resistant acid phosphatase (TRAP) activity (commercial kit). Monocultures of SCC9 cells (irradiated or not) were analyzed for the expression of IL-11 and PTHrP (by PCR). Irradiated SCC9 cells+PBMC co-cultures presented a significant reduction in TRAP activity (especially with 780 nm, 70 mW irradiation). Regardless the intracellular signaling pathway inhibitor, the decrease in TRAP activity observed in the co-cultures involving irradiated SCC9 cells was more notorious with 780 nm-4 J/cm2-70 mW. SCC9 cells irradiated with a low output power (780 nm-4 J/cm2-40 mW and 660 nm-4 J/cm2-40 mW) and cultured for 2 days presented increased expression of IL-11 and PTHrP. In 9 days cultures, expression of these molecules was lower than in non-irradiated cells. Laser irradiation (780 nm/70 mw/4 J/cm2) of SCC9 cells is able to decrease the pro-osteoclastogenic potential of those cells.
ABSTRACTS Abstracts e151 It was evaluated and followed the mouth situation of oncologic patients in intensive care units, it was applied the right treatment of each patient, correlating results of oral hygiene with infections oral cavity, showing that specialized oral care in ICU keep the hygiene and health of the hospitalized patient. The hygiene was made with chlorhexidine 0.12% non-alcoholic. In the patients that presented oral injuries, the treatment was made by using an anti-inflammatory compound, VEGELIP associated to triancionoloma. Low-density laser was used to achieve epithelization. To the dry mouth it was used artificial saliva. In those who has shown high level of oral dryness, it was used dexpantenol with vitamins A, D, E, alantoine, highly recommended to dermatologic injuries, as a healer. The numbers of patients studied was 347 between the years of 2014/2015. It was found the following oral alterations: aphthous stomatitis, mucositis, bleeding fissures, dental biofilm, periodontal disease, dry lips and dry mouth. Three was an improvement in the health state in all cases. The monitoring of the patients by the odontologic team in The ICU and the observation after they left, has shown fundamental importance in the improvement of the systemic health of the patients.
RP126 - IDENTIFICATION AND CHARACTERIZATION OF CANCER STEM CELLS MARKERS IN SCC9 CELLS: PRELIMINARY RESULTS. FLORENCE JUANA MARIA CUADRA, DÉBORA CAMPANELLA BASTOS, REBECA NASCIMENTO BARROS, FERNANDA MOREIRA, RICARDO DELLA COLLETA, EDGARD GRANER.
RP128 - IMMUNOHISTOCHEMICAL ANALYSIS OF MYOFIBROBLASTS, EMMPRIN AND MMP-13 IN EPITHELIAL ODONTOGENIC TUMORS. LUIZ ARTHUR BARBOSA DA SILVA, MARCELO ANDERSON BARBOSA NASCIMENTO, PEDRO PAULO DE ANDRADE SANTOS, CASSIANO FRANCISCO WEEGE NONAKA, LEÃO PEREIRA PINTO, ROSEANA DE ALMEIDA FREITAS, LÉLIA BATISTA DE SOUZA.
Cancer stem cells (CSCs) are a subpopulation of tumor cells associated with cancer initiation, progression and treatment failures of several malignancies, including oral squamous cells carcinoma (OSCC). Previous studies of our group isolated a high metastatic OSCC cell line (SCC9 ZsGreen LN1) by in vivo selection from the SCC9 cell line. Expression of surface markers for CSCs in SCC9 has not been described. Therefore, the goal of this study is to identify, characterize and compare the presence of CSCs in the SCC9 and SCC9 ZsGreen LN1 cell lines. Study Design: Subpopulation of CSCs in cultivated SCC9 was identified by flow cytometry using the following surface markers: CD44 standard (and its isoforms, CD44v3 and CD44v6), CD133, CD326, CD24 and CD271. Preliminary Results: SCC9 revealed high expression of CD44 standard, CD44v3, CD44v6, CD133, CD326 and CD271 and low expression of CD24. Conclusion: Preliminary results demonstrate that SCC9 showed cells with double positive staining for markers CD44s+/ CD326+, CD44s+/CD44v6, CD44s+/CD133+, CD44s+/ CD271+. Further analysis with triple staining and experiments will be performed to characterize and compare the CSCs populations present in SCC9 with SCC9 ZsGreen LN1 cell line and may be useful by providing evidences of potential therapeutic targets. (FAPESP 14/20832-3).
Investigate the presence of myofibroblasts in epithelial odontogenic tumors by immunohistochemistry and correlate the findings with tumor aggressiveness, as check the inducing function of EMMPRIN in stimulating MMP-13. Study Design: Twenty solid ameloblastomas (SAs), 10 unicystic ameloblastomas (UAs), 20 odontogenic keratocysts (OKCs) and 20 adenomatoid odontogenic tumors (AOTs) were selected. For evaluation of the presence of myofibroblasts, anti-aSMA-immunoreactive cells were quantified in connective tissue near the epithelium. The expression of EMMPRIN and MMP-13 was evaluated in epithelial and connective tissue. Results: A higher concentration of myofibroblasts was observed in SAs (mean of 30.55), followed by OKCs (22.50), UAs (20.80), and AOTs (19.15) (P ¼ .001). There was no significant correlation between the immunoexpression of EMMPRIN or MMP-13 and the number of myofibroblasts (P > .05). Significant correlation was found between MMP-13 and EMMPRIN in epithelial (P ¼ .004) and connective component (P < .001). Conclusions: The larger number of myofibroblasts suggests that these cells are one of the factors responsible for the more aggressive biologic behavior. Positive correlation between EMMPRIN and MMP-13 in epithelial and connective component of odontogenic lesions analyzed, confirm the inducing function of EMMPRIN in stimulating the expression of MMP-13.
RP127 - EVALUATION AND TREATMENT OF MOUTH CONDITIONS IN ONCOLOGIC PATIENTS IN INTENSIVE CARE UNITS (ICU). ERICA DA SILVA CARVALHO, DIEGO VERISSIMO JUNIOR, MONICA CAROLINA ARAKIAN DE LIMA, IANA VITORIA NICACIO MIRANDA, GIULY MAIARA BARBOSA ARIZA, LIA MIZOBE ONO, LIONEI NOBRE CABRAL.
RP129 - ORAL CANCER X INHERITANCE: FAMILIAR HISTORY OF MALIGNANCIES IN FIRST GRADE RELATIVES OF ORAL CANCER PATIENTS. CAIO NAOKI ISHIKAWA, GESSICA DE SOUZA, FERNANDINA ALVES MOREIRA, PRISCILA SILVA, PAULA SENA DA MATA, CALUDIA YUMI MAEDA, DESIREE ROSA CAVALCANTI.
RP122 - RISK FACTORS IN LARYNGECTOMIZED PATIENTS WITH PHARYNGOCUTANEOUS FISTULA. JANAÍNA ZAVITOSKI DA SILVA, ANNE CRISTINA DE FARIA COCATO, DANIELA BRITO BASTOS, INGRID DA SILVA SANTOS, ÉDER RICARDO BIASOLI, GLAUCO ISSAMU MIYAHARA, JOÃO JÚNIOR GOMES. The most common complication associated with the total laryngectomy is the appearance of fistula pharyngocutaneous, manifested in the first days after surgery and influencing the outcome of therapeutic evolution among laryngectomized patients. The aim of this research was to identify the risk factors that contribute to the formation of pharyngocutaneous fistula in patients submitted to the total laryngectomy surgery in a specialized center in the multidisciplinary treatment of head and neck cancer. A retrospective analysis of data was performed through this service reports referring to services performed since 1991 until 2012. There were found 81 patients; regarding gender, race, age, comorbidities, clinical stage, primary tumor site, previous tracheotomy, previous radiotherapy, weight/ height, time of appearance of the fistula, type of cervical dissection and survival; none showed statistical significance for fistula according to the chi-square test or Fisher exact test when applicable, considering P <.05 significant. It was concluded that the association of risk factors carry more significant role in the appearance of the fistula rather than a single factor. The early identification of the risk factors is extremely important for the planning of interventions to ensure intensive care and laryngeal cancer patients’ rights.
RP123 - THE POTENTIAL ROLE OF FAMILY HEALTH STRATEGY ON PROVIDE INFORMATION ABOUT PEOPLE AT RISK FOR ORAL CANCER. MAIANE NASCIMENTO, THAIS GONÇALES DOS SANTOS ANDRADE, PAULA SENA DA MATA, CLAUDIA YUMI MAEDA, PRISCILA SANTANA DA SILVA, FERNANDINA ALVES MOREIRA, DESIREE ROSA CAVALCANTI. Family Health Strategy (FHS) is a Brazilian program proposed to reorient health care model by multiprofessional teams. The Community Health Agents (CHA) plays a key role in the program and can provide these teams with information about people at risk for oral cancer.
OOOO August 2017 Objective: To obtain the prevalence and the localization of tobacco and alcohol consumers with information provided by CHA. Study Design: The data about habits by gender and age were collected in a Brazilian community served by FHS. The addresses of people with habits were registered. Results: A total of 4047 people were mapped (1952 males, 2095 females patients), being 2530 over 40 years (1199 males, 1331 females); 228 people (5.6%) were identified as tobacco consumers (151 males; 75 females) and 71 people (1.75%) as alcohol consumers (64 males; 7 females). For males over 40 years, the prevalence for tobacco was 10.4% and for alcohol 5.1%. Conclusion: The information provided by CHA was appropriate and allowed to calculate the prevalence of habits and the localization of these people in the community. The information is being used in a target model of oral screening and to follow the people at risk.
RP124 - BONE TRABECULAE: MARROW AND FIBROUS: CARTILAGINOUS LAYERS RATIO ARE AGE- BUT NOT GENDER-RELATED IN CONDYLAR HYPERPLASIA. FABIO RAMOA PIRES, NATÁLIA SANTOS CARNEIRO, TERESA CRISTINA RIBEIRO BARTHOLOMEU DOS SANTOS. Condylar hyperplasia is a developmental disorder characterized by enlargement of the mandibular condyle leading to abnormal bone growth and maxillofacial disturbances. Very little information is available on the histologic features that characterize the condition and the gender- and age-related differences. Objective: To compare the distribution of bone trabeculae:bone marrow and fibrous:cartilaginous layers in condylar hyperplasias according to the age and gender of the affected patients. Study Design: 30 condylar hyperplasias were selected and the mean ratio of bone trabeculae:bone marrow and fibrous:cartilaginous layers were calculated after analyzing 5 high power fields from each slide; values were compared by age and gender of the affected patients. Results: Sample included 19 females and 11 males (mean age 22 years, range 14-37). There were no female:male differences when comparing mean age of patients (P¼.258), bone trabeculae:bone marrow ratio (P¼.927) and fibrous:cartilaginous layers ratio (P¼.067). The correlation of age of the affected patients and bone trabeculae:bone marrow ratio (P¼.01) and fibrous:cartilaginous layers ratio (P¼.009) were both statistically significant. Conclusion: Bone trabeculae:bone marrow ratio and fibrous:cartilaginous layers ratio do not depend on gender but are associated with age of the affected patients by condylar hyperplasia. The authors thank FAPERJ for the financial support for the study.
RP125 - OSTEOCLASTOGENIC POTENTIAL OF ORAL CARCINOMA CELLS CAN BE MODULATED BY LOW LEVEL LASER (LLL). KRISTIANNE PORTA SANTOS FERNANDES, TATIANA DIAS SCHALCH, JOÃO COSTA-RODRIGUES, MÔNICA PEREIRA GARCIA, RAQUEL AGNELLI MESQUITAFERRARI, SANDRA KALLIL BUSSADORI, MARIA HELENA FERNANDES.
OOOO Volume 124, Number 2 This study aimed to analyze the effect of low-level laser on the osteoclastogenic potential of a squamous cell carcinoma cell line (SCC9). Irradiated SCC9 cells (660 /780 nm; 40 /70 mW; 2, 4 and 6 J/cm2) were cultured with human osteoclast precursors (PBMC). Co-cultures with non-irradiated SCC9 cells served as control. After 7, 14 and 21 days, the co-cultures (treated or not with specific inhibitors of MEK, NFkB, p38 and JNK pathways) were evaluated for the tartrate-resistant acid phosphatase (TRAP) activity (commercial kit). Monocultures of SCC9 cells (irradiated or not) were analyzed for the expression of IL-11 and PTHrP (by PCR). Irradiated SCC9 cells+PBMC co-cultures presented a significant reduction in TRAP activity (especially with 780 nm, 70 mW irradiation). Regardless the intracellular signaling pathway inhibitor, the decrease in TRAP activity observed in the co-cultures involving irradiated SCC9 cells was more notorious with 780 nm-4 J/cm2-70 mW. SCC9 cells irradiated with a low output power (780 nm-4 J/cm2-40 mW and 660 nm-4 J/cm2-40 mW) and cultured for 2 days presented increased expression of IL-11 and PTHrP. In 9 days cultures, expression of these molecules was lower than in non-irradiated cells. Laser irradiation (780 nm/70 mw/4 J/cm2) of SCC9 cells is able to decrease the pro-osteoclastogenic potential of those cells.
ABSTRACTS Abstracts e151 It was evaluated and followed the mouth situation of oncologic patients in intensive care units, it was applied the right treatment of each patient, correlating results of oral hygiene with infections oral cavity, showing that specialized oral care in ICU keep the hygiene and health of the hospitalized patient. The hygiene was made with chlorhexidine 0.12% non-alcoholic. In the patients that presented oral injuries, the treatment was made by using an anti-inflammatory compound, VEGELIP associated to triancionoloma. Low-density laser was used to achieve epithelization. To the dry mouth it was used artificial saliva. In those who has shown high level of oral dryness, it was used dexpantenol with vitamins A, D, E, alantoine, highly recommended to dermatologic injuries, as a healer. The numbers of patients studied was 347 between the years of 2014/2015. It was found the following oral alterations: aphthous stomatitis, mucositis, bleeding fissures, dental biofilm, periodontal disease, dry lips and dry mouth. Three was an improvement in the health state in all cases. The monitoring of the patients by the odontologic team in The ICU and the observation after they left, has shown fundamental importance in the improvement of the systemic health of the patients.
RP126 - IDENTIFICATION AND CHARACTERIZATION OF CANCER STEM CELLS MARKERS IN SCC9 CELLS: PRELIMINARY RESULTS. FLORENCE JUANA MARIA CUADRA, DÉBORA CAMPANELLA BASTOS, REBECA NASCIMENTO BARROS, FERNANDA MOREIRA, RICARDO DELLA COLLETA, EDGARD GRANER.
RP128 - IMMUNOHISTOCHEMICAL ANALYSIS OF MYOFIBROBLASTS, EMMPRIN AND MMP-13 IN EPITHELIAL ODONTOGENIC TUMORS. LUIZ ARTHUR BARBOSA DA SILVA, MARCELO ANDERSON BARBOSA NASCIMENTO, PEDRO PAULO DE ANDRADE SANTOS, CASSIANO FRANCISCO WEEGE NONAKA, LEÃO PEREIRA PINTO, ROSEANA DE ALMEIDA FREITAS, LÉLIA BATISTA DE SOUZA.
Cancer stem cells (CSCs) are a subpopulation of tumor cells associated with cancer initiation, progression and treatment failures of several malignancies, including oral squamous cells carcinoma (OSCC). Previous studies of our group isolated a high metastatic OSCC cell line (SCC9 ZsGreen LN1) by in vivo selection from the SCC9 cell line. Expression of surface markers for CSCs in SCC9 has not been described. Therefore, the goal of this study is to identify, characterize and compare the presence of CSCs in the SCC9 and SCC9 ZsGreen LN1 cell lines. Study Design: Subpopulation of CSCs in cultivated SCC9 was identified by flow cytometry using the following surface markers: CD44 standard (and its isoforms, CD44v3 and CD44v6), CD133, CD326, CD24 and CD271. Preliminary Results: SCC9 revealed high expression of CD44 standard, CD44v3, CD44v6, CD133, CD326 and CD271 and low expression of CD24. Conclusion: Preliminary results demonstrate that SCC9 showed cells with double positive staining for markers CD44s+/ CD326+, CD44s+/CD44v6, CD44s+/CD133+, CD44s+/ CD271+. Further analysis with triple staining and experiments will be performed to characterize and compare the CSCs populations present in SCC9 with SCC9 ZsGreen LN1 cell line and may be useful by providing evidences of potential therapeutic targets. (FAPESP 14/20832-3).
Investigate the presence of myofibroblasts in epithelial odontogenic tumors by immunohistochemistry and correlate the findings with tumor aggressiveness, as check the inducing function of EMMPRIN in stimulating MMP-13. Study Design: Twenty solid ameloblastomas (SAs), 10 unicystic ameloblastomas (UAs), 20 odontogenic keratocysts (OKCs) and 20 adenomatoid odontogenic tumors (AOTs) were selected. For evaluation of the presence of myofibroblasts, anti-aSMA-immunoreactive cells were quantified in connective tissue near the epithelium. The expression of EMMPRIN and MMP-13 was evaluated in epithelial and connective tissue. Results: A higher concentration of myofibroblasts was observed in SAs (mean of 30.55), followed by OKCs (22.50), UAs (20.80), and AOTs (19.15) (P ¼ .001). There was no significant correlation between the immunoexpression of EMMPRIN or MMP-13 and the number of myofibroblasts (P > .05). Significant correlation was found between MMP-13 and EMMPRIN in epithelial (P ¼ .004) and connective component (P < .001). Conclusions: The larger number of myofibroblasts suggests that these cells are one of the factors responsible for the more aggressive biologic behavior. Positive correlation between EMMPRIN and MMP-13 in epithelial and connective component of odontogenic lesions analyzed, confirm the inducing function of EMMPRIN in stimulating the expression of MMP-13.
RP127 - EVALUATION AND TREATMENT OF MOUTH CONDITIONS IN ONCOLOGIC PATIENTS IN INTENSIVE CARE UNITS (ICU). ERICA DA SILVA CARVALHO, DIEGO VERISSIMO JUNIOR, MONICA CAROLINA ARAKIAN DE LIMA, IANA VITORIA NICACIO MIRANDA, GIULY MAIARA BARBOSA ARIZA, LIA MIZOBE ONO, LIONEI NOBRE CABRAL.
RP129 - ORAL CANCER X INHERITANCE: FAMILIAR HISTORY OF MALIGNANCIES IN FIRST GRADE RELATIVES OF ORAL CANCER PATIENTS. CAIO NAOKI ISHIKAWA, GESSICA DE SOUZA, FERNANDINA ALVES MOREIRA, PRISCILA SILVA, PAULA SENA DA MATA, CALUDIA YUMI MAEDA, DESIREE ROSA CAVALCANTI.