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Subject index for volume 5
REGULATORY
TOXICOLXXiY
AND
PHARMACOLOGY
5,489-492
(1985)
Subject Index for Volume 5 A
Acceptable daily intake (ADI) DDT, establishment by consideration of major biological implications, 332 estimation in safety assessmentof pesticides, 460 Additives food, see Food additives petroleum industry: environmental health aspects, 284 Ames test application in toxicology, 59 Animal models chimpanzee, role in risk assessmentof xenobiotics, 182 B
Bioaccumulation Cl/N-containing compounds, evaluation for classification and establishment of water quality criteria, 123 organic chemicals in fish, relationship to water solubility and octanol/water partition coefficients, review, 422
Bioavailability cigarette smoke: Federal Trade Commission analytical yields as predictors, evaluation, 3 14 Biodegradability Cl/N-containing compounds, evaluation for classification and establishment of water quality criteria, 123
Bladder stones induction by terephthalic acid, dimethyl terephthalate, and melamine: relevance to risk assessment(rat), 294
Carbon monoxide yields determined by Federal Trade Commission, evaluation as predictors of cigarette smoke bioavailability, 3 14 Carcinogens epigenetic and genotoxic, identification in liver culture systems,implications for risk assessment, 132 CERCLA, see Comprehensive Environmental Response, Compensation, and Liability Act Chemical abuse inhalation of volatile organic substances:history, abuser population, symptomatology, pharmacotoxicology, and remediation, I8 Chemicals Cl/N-containing: toxicity, biodegradability, and bioaccumulation, evaluation for classification and establishment of water quality criteria, 123 industrial, mutagenicity in cultured mammalian cells, testing strategy, 207 organic volatile, abuse by inhalation: history, abuser population, symptomatology, phannacotoxicology, and remediation, 18 water solubility, octanol/water partition coefficients, and bioconcentration in fish, relationship, review, 422
regulation by Swiss environmental protection law, legal and political aspects, 145 volatile, toxic, risk management, role of Tanner Bill introduction into California Legislature, 410 xenobiotic metabolism: interindividual variation, implications for use of uncertainty factors, 190 risk assessment,role of chimpanzee as animal model, 182
Bone marrow Redentin cytogenetic effects in viva (mouse), 204
Chlorine and/or nitrogen-containing compounds: toxicity, biodegradability, and bioaccumulation, evaluation for classification and establishment of water quality criteria, 123 Cigarette smoke bioavailability: Federal Trade Commission analytical yields as predictors, evaluation, 3 14 Combustion stored insecticides, short-term health risks, evaluation with smoke dispersal model, 197 Comprehensive Environmental Response, Compensation, and Liability Act basic litigation principles, 38
C Cancer risk assessment carcinogenic potency estimation techniques, review, 430 with quantitative models: relevance and scientific merit, 175
use of epidemiology, scientific data, and regulatory authority esophageal cancer, 255 introduction, 225 liver cancer, 384 489
0273-2300185
$3.00
Copyright Q 1985 by Academic Pms, Inc. All rights of reproduction in any form reserved.
SUBJECT INDEX
490
Culture systems hepatic, identification of epigenetic and genotoxic carcinogens, implications for risk assessment, 132 n
DDT acceptable daily intake, establishment by consideration of major biological implications, 332 6,8-Diethyl-5-hydroxy-4-oxo-4H-I-benzopyran-2 carboxylic acid, see FPL 52751 Dimethyl terephthalate bladder stone induction, relevance to risk assessment (rat), 294 DNA recombinant, technology, impact on drug development, 212 Drug development FPL 52757, hepatotoxicity in humans after preclinical testing: incident assessmentand implications, 109 impact of recombinant DNA technology, 2 12 Drugs mutagenicity, risk assessment: interpretation and significance of test results, 79 over-the-counter, safety evaluation, 101 safety evaluation application of pharmacokinetics, 3 and efficacy evaluation: past, current, and future trends, 24 1 E Editorial dilemma of DDT, 329 Pharmacopeia of the United States of America, 21st edition, and National Formulary, 16th edition, 1 risk decision making, 12 1 use of animal models for toxicological evaluations, legal aspects, 239 Efficacy evaluation drugs: past, current, and future trends, 241 Effluents power industry, selenium-containing, regulation based on ecological data, 465 Environmental health aspects regarding petroleum industry additives, 284 Environmental insurance issues in superfund litigation, 38 Environmental law introduction of Tanner Bill into California Legislature, role in risk management of toxic air contaminants, 410 Swiss, regulation of chemicals, legal and political aspects, 145 Epidemiology cancer, survey data: use in risk assessment,225 determination of risk factors in esophageal cancer, 255 liver cancer, 384
Esophagus cancer risk assessment: use of epidemiology, scientific data, and regulatory authority, 255 1‘I@-Estradiol and zeranol, as anabolic agents: toxicological properties, comparison, 276; erratum, 487 Etiology esophageal cancer, determination, 255 F
FDA, see Food and Drug Administration Federal Trade Commission analytical cigarette yields, evaluation as predictors of smoke bioavailability, 3 14 Finland validity assessment of pesticide toxicity studies performed in U.S. laboratories, 4 16 Food additives toxicity parameters, dependence on chemical structure, evaluation in priority-based assessment of food additives by FDA, 152 Food and Drug Administration priority-based assessmentof food additives: toxicity parameters, dependence on chemical structure, 152 regulatory authority, application in cancer risk assessment, 225 Food production safety problems associated with genetic engineering, 405 in Third World countries, role of chemical industry, 65 FPL 52157 hepatotoxicity in humans after preclinical testing: incident assessmentand implications, 109 G Genetic engineering application in food production, associated safety problems, 405 recombinant DNA technology, impact on drug development, 2 12 H
Hazardous wastes disposal, issues in superfund litigation, 38 Health public, see Public health
Industry chemical, role in development of Third World countries, 65 petroleum, additives: environmental health aspects,284 power, selenium-containing effluents, regulation based on ecological data, 465
SUBJECT INDEX L
Liability joint and several, in superfund litigation, review, 38 Litigation superfund, basic principles, 38 Liver cancer risk assessment: use of epidemiology, scientific data, and regulatory authority, 384 M
Melamine bladder stone induction, relevance to risk assessment (rat), 294 Models animal, see Animal models quantitative, for cancer risk assessment: relevance and scientific merit, I75 for sensitization testing applied in drug safetyevaluation, overview, 46 smoke dispersal, evaluation of short-term health risks of insecticide storage facility fire, 197 Mutagenicity drugs, risk assessment: interpretation and significance of test results, 79 industrial chemicals in cultured mammalian cells, testing strategy, 207 Redentin, cytogenetic and histologic analysis in murine bone marrow cells and spermatocytes in viva 204 N
National Formulary United States, 16th edition, editorial, 1 Nicotine yields determined by Federal Trade Commission, evaluation as predictors of cigarette smoke bioavailability, 3 14 Nitrogen and/or chlorine-containing compounds: toxicity, biodegradability, and bioaccumulation, evaluation for classification and establishment of water quality criteria, I23 P
Partition coefficients octanol/water, for organic chemicals, relationship to water solubility and bioconcentration in fish, review, 422 Pesticides exposure to fire in storage facility, short-term health risks, evaluation with smoke dispersal model, 197 safetyassessment:estimation of acceptable daily intake, 460 toxicity studies performed in U.S. laboratories, validity assessment in Finland, 4 16 Pharmacokinetics application in drug safety evaluation, 3
491
Pharmacopeia United States, 2 I st edition, editorial, I Public health in Third World countries, role of chemical industry, 65 R
Redentin cytogenetic and histologic effectson murine bone marrow cells and spermatocytes in viva, 204 Risk assessment,see also Safety evaluation Ames test application, 59 cancer, see Cancer risk assessment drug mutagenicity: interpretation and significance of test results, 79 editorial, 12 1 epigenetic and genotoxic carcinogens, 132 insecticide storage facility fire, short-term effects,evaluation with smoke dispersal model, 197 terephthahc acid, dimethyl temphthalate, and melamine, relevance of bladder stone induction (rat), 294 xenobiotics, role of chimpanzee as animal model, 182 Risk management toxic air contaminants, role of Tanner Bill introduction into California Legislature, 410 S
Safety evaluation, see also Risk assessment drugs application of pharmacokinetics, 3 and other substances, role of sensitization testing, 46 past, current, and future trends, 241 genetic engineering techniques in food production, 405 over-the-counter products, 101 pesticides: estimation of acceptable daily intake, 460 Selenium -containing power industry effluents, regulation based on ecological data, 465 Sensitization testing theoretical and practical aspects,models, and application in drug safety evaluation, 46 Smoke cigarette, see Cigarette smoke toxic, from combustion of stored insecticides, short-term health risks, evaluation with mathematical model, 197 Solubility organic chemicals in water, relationship to octanol/water partition coefficients and bioconcentration in ftsh, review, 422 Spermiogenesis Redentin histologic effectsin viva (mouse), 204 Superfund, see Comprehensive Environmental Response, Compensation, and Liability Act Surveys cancer incidence and mortality data, application in disease risk assessment,225
492
SUBJECT INDEX 1
Tar yields determined by Federal Trade Commission, evaluation as predictors of cigarette smoke bioavailability, 3 14 Terephthalic acid bladder stone induction, relevance to risk assessment (rat), 294 Tests Ames, see Ames test drug mutagenic risk assessment:interpretation and significance of results, 79 mutagenicity of industrial chemicals in cultured mammalian cells, experimental strategy, 207 Toxicity Cl/N-containing compounds, evaluation for classification and establishment of water quality criteria, 123 food additives, dependence on chemical structure, evaluation in priority-based assessment of food additives by FDA, 152 hepatic, FPL 52757 in humans after preclinical testing: incident assessmentand implications, 109 pesticides, studies performed in U.S. laboratories, validity assessment in Finland, 4 16
Toxicology Ames test application, 59 17j3-estradiol and zeranol as anabolic agents, comparative evaluation, 276; erratum, 487 U
Uncertainty factors evaluation in relation to interindividual variation in response to xenobiotics, 190
w Wastes hazardous, see Hazardous wastes Water quality criteria, establishment for Cl/N-containing compounds by evaluation of toxicity, biodegradability, and bioaccumulation, 123 Z Zeranol and 17pestradio1, as anabolic agents: toxicological properties, comparison, 276; erratum, 487
TOXICOLXXiY
AND
PHARMACOLOGY
5,489-492
(1985)
Subject Index for Volume 5 A
Acceptable daily intake (ADI) DDT, establishment by consideration of major biological implications, 332 estimation in safety assessmentof pesticides, 460 Additives food, see Food additives petroleum industry: environmental health aspects, 284 Ames test application in toxicology, 59 Animal models chimpanzee, role in risk assessmentof xenobiotics, 182 B
Bioaccumulation Cl/N-containing compounds, evaluation for classification and establishment of water quality criteria, 123 organic chemicals in fish, relationship to water solubility and octanol/water partition coefficients, review, 422
Bioavailability cigarette smoke: Federal Trade Commission analytical yields as predictors, evaluation, 3 14 Biodegradability Cl/N-containing compounds, evaluation for classification and establishment of water quality criteria, 123
Bladder stones induction by terephthalic acid, dimethyl terephthalate, and melamine: relevance to risk assessment(rat), 294
Carbon monoxide yields determined by Federal Trade Commission, evaluation as predictors of cigarette smoke bioavailability, 3 14 Carcinogens epigenetic and genotoxic, identification in liver culture systems,implications for risk assessment, 132 CERCLA, see Comprehensive Environmental Response, Compensation, and Liability Act Chemical abuse inhalation of volatile organic substances:history, abuser population, symptomatology, pharmacotoxicology, and remediation, I8 Chemicals Cl/N-containing: toxicity, biodegradability, and bioaccumulation, evaluation for classification and establishment of water quality criteria, 123 industrial, mutagenicity in cultured mammalian cells, testing strategy, 207 organic volatile, abuse by inhalation: history, abuser population, symptomatology, phannacotoxicology, and remediation, 18 water solubility, octanol/water partition coefficients, and bioconcentration in fish, relationship, review, 422
regulation by Swiss environmental protection law, legal and political aspects, 145 volatile, toxic, risk management, role of Tanner Bill introduction into California Legislature, 410 xenobiotic metabolism: interindividual variation, implications for use of uncertainty factors, 190 risk assessment,role of chimpanzee as animal model, 182
Bone marrow Redentin cytogenetic effects in viva (mouse), 204
Chlorine and/or nitrogen-containing compounds: toxicity, biodegradability, and bioaccumulation, evaluation for classification and establishment of water quality criteria, 123 Cigarette smoke bioavailability: Federal Trade Commission analytical yields as predictors, evaluation, 3 14 Combustion stored insecticides, short-term health risks, evaluation with smoke dispersal model, 197 Comprehensive Environmental Response, Compensation, and Liability Act basic litigation principles, 38
C Cancer risk assessment carcinogenic potency estimation techniques, review, 430 with quantitative models: relevance and scientific merit, 175
use of epidemiology, scientific data, and regulatory authority esophageal cancer, 255 introduction, 225 liver cancer, 384 489
0273-2300185
$3.00
Copyright Q 1985 by Academic Pms, Inc. All rights of reproduction in any form reserved.
SUBJECT INDEX
490
Culture systems hepatic, identification of epigenetic and genotoxic carcinogens, implications for risk assessment, 132 n
DDT acceptable daily intake, establishment by consideration of major biological implications, 332 6,8-Diethyl-5-hydroxy-4-oxo-4H-I-benzopyran-2 carboxylic acid, see FPL 52751 Dimethyl terephthalate bladder stone induction, relevance to risk assessment (rat), 294 DNA recombinant, technology, impact on drug development, 212 Drug development FPL 52757, hepatotoxicity in humans after preclinical testing: incident assessmentand implications, 109 impact of recombinant DNA technology, 2 12 Drugs mutagenicity, risk assessment: interpretation and significance of test results, 79 over-the-counter, safety evaluation, 101 safety evaluation application of pharmacokinetics, 3 and efficacy evaluation: past, current, and future trends, 24 1 E Editorial dilemma of DDT, 329 Pharmacopeia of the United States of America, 21st edition, and National Formulary, 16th edition, 1 risk decision making, 12 1 use of animal models for toxicological evaluations, legal aspects, 239 Efficacy evaluation drugs: past, current, and future trends, 241 Effluents power industry, selenium-containing, regulation based on ecological data, 465 Environmental health aspects regarding petroleum industry additives, 284 Environmental insurance issues in superfund litigation, 38 Environmental law introduction of Tanner Bill into California Legislature, role in risk management of toxic air contaminants, 410 Swiss, regulation of chemicals, legal and political aspects, 145 Epidemiology cancer, survey data: use in risk assessment,225 determination of risk factors in esophageal cancer, 255 liver cancer, 384
Esophagus cancer risk assessment: use of epidemiology, scientific data, and regulatory authority, 255 1‘I@-Estradiol and zeranol, as anabolic agents: toxicological properties, comparison, 276; erratum, 487 Etiology esophageal cancer, determination, 255 F
FDA, see Food and Drug Administration Federal Trade Commission analytical cigarette yields, evaluation as predictors of smoke bioavailability, 3 14 Finland validity assessment of pesticide toxicity studies performed in U.S. laboratories, 4 16 Food additives toxicity parameters, dependence on chemical structure, evaluation in priority-based assessment of food additives by FDA, 152 Food and Drug Administration priority-based assessmentof food additives: toxicity parameters, dependence on chemical structure, 152 regulatory authority, application in cancer risk assessment, 225 Food production safety problems associated with genetic engineering, 405 in Third World countries, role of chemical industry, 65 FPL 52157 hepatotoxicity in humans after preclinical testing: incident assessmentand implications, 109 G Genetic engineering application in food production, associated safety problems, 405 recombinant DNA technology, impact on drug development, 2 12 H
Hazardous wastes disposal, issues in superfund litigation, 38 Health public, see Public health
Industry chemical, role in development of Third World countries, 65 petroleum, additives: environmental health aspects,284 power, selenium-containing effluents, regulation based on ecological data, 465
SUBJECT INDEX L
Liability joint and several, in superfund litigation, review, 38 Litigation superfund, basic principles, 38 Liver cancer risk assessment: use of epidemiology, scientific data, and regulatory authority, 384 M
Melamine bladder stone induction, relevance to risk assessment (rat), 294 Models animal, see Animal models quantitative, for cancer risk assessment: relevance and scientific merit, I75 for sensitization testing applied in drug safetyevaluation, overview, 46 smoke dispersal, evaluation of short-term health risks of insecticide storage facility fire, 197 Mutagenicity drugs, risk assessment: interpretation and significance of test results, 79 industrial chemicals in cultured mammalian cells, testing strategy, 207 Redentin, cytogenetic and histologic analysis in murine bone marrow cells and spermatocytes in viva 204 N
National Formulary United States, 16th edition, editorial, 1 Nicotine yields determined by Federal Trade Commission, evaluation as predictors of cigarette smoke bioavailability, 3 14 Nitrogen and/or chlorine-containing compounds: toxicity, biodegradability, and bioaccumulation, evaluation for classification and establishment of water quality criteria, I23 P
Partition coefficients octanol/water, for organic chemicals, relationship to water solubility and bioconcentration in fish, review, 422 Pesticides exposure to fire in storage facility, short-term health risks, evaluation with smoke dispersal model, 197 safetyassessment:estimation of acceptable daily intake, 460 toxicity studies performed in U.S. laboratories, validity assessment in Finland, 4 16 Pharmacokinetics application in drug safety evaluation, 3
491
Pharmacopeia United States, 2 I st edition, editorial, I Public health in Third World countries, role of chemical industry, 65 R
Redentin cytogenetic and histologic effectson murine bone marrow cells and spermatocytes in viva, 204 Risk assessment,see also Safety evaluation Ames test application, 59 cancer, see Cancer risk assessment drug mutagenicity: interpretation and significance of test results, 79 editorial, 12 1 epigenetic and genotoxic carcinogens, 132 insecticide storage facility fire, short-term effects,evaluation with smoke dispersal model, 197 terephthahc acid, dimethyl temphthalate, and melamine, relevance of bladder stone induction (rat), 294 xenobiotics, role of chimpanzee as animal model, 182 Risk management toxic air contaminants, role of Tanner Bill introduction into California Legislature, 410 S
Safety evaluation, see also Risk assessment drugs application of pharmacokinetics, 3 and other substances, role of sensitization testing, 46 past, current, and future trends, 241 genetic engineering techniques in food production, 405 over-the-counter products, 101 pesticides: estimation of acceptable daily intake, 460 Selenium -containing power industry effluents, regulation based on ecological data, 465 Sensitization testing theoretical and practical aspects,models, and application in drug safety evaluation, 46 Smoke cigarette, see Cigarette smoke toxic, from combustion of stored insecticides, short-term health risks, evaluation with mathematical model, 197 Solubility organic chemicals in water, relationship to octanol/water partition coefficients and bioconcentration in ftsh, review, 422 Spermiogenesis Redentin histologic effectsin viva (mouse), 204 Superfund, see Comprehensive Environmental Response, Compensation, and Liability Act Surveys cancer incidence and mortality data, application in disease risk assessment,225
492
SUBJECT INDEX 1
Tar yields determined by Federal Trade Commission, evaluation as predictors of cigarette smoke bioavailability, 3 14 Terephthalic acid bladder stone induction, relevance to risk assessment (rat), 294 Tests Ames, see Ames test drug mutagenic risk assessment:interpretation and significance of results, 79 mutagenicity of industrial chemicals in cultured mammalian cells, experimental strategy, 207 Toxicity Cl/N-containing compounds, evaluation for classification and establishment of water quality criteria, 123 food additives, dependence on chemical structure, evaluation in priority-based assessment of food additives by FDA, 152 hepatic, FPL 52757 in humans after preclinical testing: incident assessmentand implications, 109 pesticides, studies performed in U.S. laboratories, validity assessment in Finland, 4 16
Toxicology Ames test application, 59 17j3-estradiol and zeranol as anabolic agents, comparative evaluation, 276; erratum, 487 U
Uncertainty factors evaluation in relation to interindividual variation in response to xenobiotics, 190
w Wastes hazardous, see Hazardous wastes Water quality criteria, establishment for Cl/N-containing compounds by evaluation of toxicity, biodegradability, and bioaccumulation, 123 Z Zeranol and 17pestradio1, as anabolic agents: toxicological properties, comparison, 276; erratum, 487