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Subject index for volume 5
FUNDAMENTAL
AND
APPLIED
TOXICOLOGY
5, 1194-l
205 ( 1985)
Subject Index for Volume 5 A
Acetaminophen hepatotoxicity, role of glutathione (rat), 806 Acetonitriles brominated and chlorinated, formed during chlorination of drinking water: mutagenic and carcinogenic properties, evaluation, 1065 Acetylcholine brain, effect of soman stereoisomers (murine blood, tissues), S252 Acetylcholine receptors nicotinic, molecular structure and functional aspects, s39 Acetylcholinesterase in central nervous system reaggregate cultures, recovery after acute diisopropylfluorophosphate exposure (mouse), 1104 in isolated brain capillaries, role in soman intoxication (rabbit), S 122 ACTH, see Adrenocorticotropin Adrenal gland cortex, degeneration by a-( I ,4dioxido-3-methylquinoxalin-2-yl)-N-methylnitrone (dog, rat), 370 diacetoxyscirpenol-induced cytotoxicity after intravenous administration (swine), 1034 Adrenocorticotropin plasma levels after soman poisoning (mouse), S6 1 Aflatoxin B, -induced enzyme-altered hepatic foci, selenium effect (rat), 320 reconstituted cytochrome P-450-induced mutagenic activation and inactivation (rat liver), 487 Alkyldimethylamine oxides commercial, toxicological evaluation: two-year chronic feeding and dermal studies (mouse, rat), 869 o-Aminoazotoluene reconstituted cytochrome P-450-induced mutagenic activation and inactivation (rat liver), 487 2-Aminofluorene reconstituted cytochrome P-450~induced mutagenic activation and inactivation (rat liver), 487 Ammonia -induced behavioral changes after inhalation exposure (mouse, rat), 1110 Anguidine, see Diacetoxyscirpenol Animal models immediate- and delayed-onset pulmonary hypersensitivity, immunotoxicologic evaluation of respiratory system,459 National Cancer Institute carcinogenesis testing program: history, survival, and growth patterns of B6C3Fl mice and F344 rats, 526; erratum, 1188 0272-0590/85 $3.00 Copyright Q 1985 by the Society of Toxicology. All rights of reproduction in any form reserved.
rodents, pulmonary function, measurement techniques, 423 Announcements Fourteenth International Cancer Congress, Budapest, August 1986,605 Fourth Annual Meeting of American Association for Aerosol Research, Albuquerque, November 1985, 804 Fourth International Conference on Neurotoxicology of Selected Chemicals: Neurotoxicology in the Fetus and Child, Little Rock, Arkansas, September 1985,205 Sixteenth Congress of International Academy of Pathology and Seventh World Congress of Academic and Environmental Pathology, Vienna, August 1986,605 Symposium on Animal Carcinogenicity Studies, Bethesda, Maryland, March 1985,206 Anticholinestemses multiple actions on chemosensitive synapses:molecular basis for prophylaxis and treatment of organophosphate poisoning (rat), S182 noncholinergic actions: present and future development, review, S270 Aroclor 1254 effect on antibody synthesis, interleukin 2 activity, and natural killer cell cytotoxicity in vivo and in vitro (rat), 158 induction of aryl hydrocarbon hydroxylase in vitro (rat hepatocytes), 7 13 Arsine hematological exposure-response quantitation (mouse), 499 Aryl hydrocarbon hydroxylase induction by chlorinated aromatic hydrocarbons in vitro (rat hepatocytes), 7 13 2’,4’,5’-hexabromobiphenyl photolysis products (rat hepatocytes), 555 Asbestos chrysotile short fibers, chronic inhalation study (monkey, rat), 327 Atropine with oximes, pretreatment: protective effect on sarinand soman-induced inhalation toxicity (rat), S84 pretreatment effect on sarin and VX poisoning (rat), S182 with pyridostigmine, pretreatment: protective effect on soman and sarin poisoning (guinea pig), S225 and soman and prahdioxime chloride interactions, ag phcation of response-surface modeling for evahration (guinea pig), S232
1194
SUBJECT INDEX B
Behavior -augmented component of paraoxon tolerance, assessment: role of reinforcement and response factors (rat), S213 locomotor activity, and carbon dioxide production as index (mouse), 962 toluene inhalation effects (mouse), 97 1 visuomotor coordination, feeding, and locomotor activity: acute toxicity of satin (marmoset), S169 wheel running, ammonia and ozone inhalation exposure effects (mouse, rat), 1110 Benzo[a]pyrene reconstituted cytochrome P-450-induced mutagenic activation and inactivation (rat liver), 487 Bile secretion, and hepatic transport, glutathione and glutathione-metal complexes (rat), 8 16 Bioassays carcinogens, National Cancer Institute program: histoty, survival, and growth patterns of B6C3Fl mice and F344 rats, 526; erratum, 1188 chronic, statistical design recommendations, letter to the editor, 1186; response to letter, 1187 dioxin-like activity based on epithelial cell proliferation and morphology changes (murine teratoma), 754 murine dermal carcinogenesis, and Salmonella/microsome mutagenesis assay: comparative evaluation of complex petroleum hydrocarbon mixtures, 382 Blood amine exposure-response quantitation (mouse), 499 coagulation and hematology, effect of intravascular T2 toxin (female swine), 893 cyclohexanone oxime-induced toxicity after acute dermal exposure or subchronic oral exposure (rabbit, rat), 128 subacute oral exposure (rabbit, rat), 117 erythrocytes, see Erythrocytes HI-6 levels after intramuscular administration (human), S89 intestinal tlow, radiation-induced increase: antihistamine effect (dog), 597 lead concentration, diet effect (monkey), 588 long-term glutathione depletion effectsafter L-buthionine-S,R-sulfoximine administration (mouse), 913 sampling site and collection method, effecton variations in baseline clinical pathology parameters (Fischer 344 rat), 1180 serum glucose and glucose counterregulation, disopyramide phosphate effect (dog), 539 Blood-brain barrier function of isolated brain capillaries, role in soman intoxication (rabbit), S 122 Blood pressure direct measurement technique in canine toxicity, evaluation, 39 1 T-2 toxin-induced changes (swine), 879
1195
BM 123, see Wl-(2Chloroethylamino)-2-butynyl-2-pyrollidine Bone marrow diacetoxyscirpenol-induced cytotoxicity after intravenous administration (swine), 1034 Brain acetylcholine, effect of soman stereoisomers (murine blood, tissues), S252 cerebellum and cerebrum, mitochondrial DNA synthesis, induction by methyl mercury (cat), 25 1 cholinergic systems, subchronic intoxication effects of diisopropyllluorophosphate at early developmental stages (rat), s204 diacetoxyscirpenol-induced cytotoxicity after intravenous administration (swine), 1034 diisopropylfluorophosphate toxicity, tolerance development: mechanisms (rat), St 7 isolated capillaries, role as blood-brain barrier in soman intoxication (rabbit), S122 metallothionein concentmtion, effects of various metals (rat), 473 neuropathic effect of soman (hen), S 180 neurotransmitter systems, acute cyanide intoxication effects(rat), S 150 N-D-omithyl amphotericin B methyl ester-induced morphologic changes, subchronic toxicity studies (dog), 737 satin- and soman-induced seizures, pathology: perspectives on medical management, SlO Bromobenzene hepatotoxicity role of glutathione (rat), 806 zinc protective effect, mechanism of action (rat), 297 5-Bromodeoxyuridine and hydroxyurea, teratogenic interaction: examination by limb culture and image analysis (mouse), 116 1 L-Buthionine-S,R-sulfoximine -induced long-term glutathione depletion, effecton lung, liver, kidney, and blood (mouse), 9 13 Butyl acrylate hydrolysis by nasal mucosal carboxylesterase in vitro (dog, mouse, rabbit, rat), 399 Butyl carbitol reproductive toxicity and teratogenicity (rabbit, rat), 1137 C Cadmium effecton metallothionein concentration in major organs (rat), 473 hepatotoxicity, role of glutathione (rat), 806 Caffeine metabolic fate after chronic consumption (female monkey), 578 Carbon dioxide challenges, evaluation of hydrogen chloride inhalation toxicity (guinea pig), 978
1196
SUBJECT INDEX
production as index of behavioral and metabolic activity (mouse), 962 and locomotor activity, toluene inhalation effects (mouse), 97 1 Carbon tetrachloride hepatotoxicity, effect of mirex and chlordecone dietary exposure (rat), 679 Carboxylesterases nasal mucosal, hydrolysis of glycol ether acetates and acrylate esters (dog, mouse, rabbit, rat), 399 role in detoxification of organophosphorus anticholinesterases and trichothecenes (rat), S29 Carcinogenicity brominated and chlorinated acetonitriles formed during chlorination of drinking water, 1065 chlorodibromomethane, evaluation (B5C3F mouse), 1128 chloroform in drinking water (B6C3Ft mouse.,OsbomeMendel rat), 760 gentian violet (B6C3Fl mouse), 902 stirofos in liver and kidney, evaluation (B6C3Fl mouse), 840 styrene monomer administration in drinking water, three-generation reproduction study (rat), 855 Carcinogenicity testing commercial alkyldimethylamine oxides, two-year chronic feeding and dermal studies (mouse, rat), 869 maximum tolerated dose, definition and evaluation, 66 with mice and rats, correlation studies of carcinogenic potency, evaluation for risk estimation, 79 National Cancer Institute bioassay program: history, survival, and growth patterns of B6C3Fl mice and F344 rats, 526; erratum, 1188 petroleum hydmcarbon complex mixtures, comparative evaluation: SalmoneIa/microsome mutagenesis assayand murine dermal carcinogenesis bioassay, 382 rat hepatic foci assay and strain A mouse lung tumor assay,comparison (review), 688 Catecholamines plasma concentrations, changes after T-2 toxin administration (swine), 879 Cell culture limb explants, examination of hydroxyurea and 5-bromodeoxyutidine teratogenic interactions (mouse), 1161 Central nervous system reaggregate cultures, acetylcholinesterase recovery after acute diisopropylfluorophosphate exposure (mouse), 1104 Cephaloridine nephrotoxicity: strain and sex differences (mouse), 1153 Chemical poisoning prophylaxis and treatment, symposium introduction, Sl
Chlordecone and mirex combination, effect on carbon tetrachloride hepatotoxicity after dietary exposure (rat), 679 Chlorination drinking water, formed brominated and chlorinated acetonitriles: mutagenic and carcinogenic properties, evaluation, 1065 Chlorine formation of chloroform, and inhibition by chlorine dioxide, mechanism of action, 305 Chlorine dioxide effect on dietary iodide absorption and distribution (rat), 672 inhibition of chloroform formation, 305 Chlorisondamine with atropine or physostigmine, pretreatment effect on sarin and VX poisoning (rat), S 182 Chlorobenzene hepatotoxicity, dose-response and temporal characteristics (rat), 105 Chlorodibromomethane carcinogenicity and hepatic and renal toxicity (B6C3F1 mouse, Fischer 344 rat), 1128 N-4-(2-Chloroethylamino)-2-butynyl-2-pyrollidine and soman, synergistic effects(rat), S78 Chloroform in drinking water, carcinogenicity evaluation (B6C3Fl mouse, Osborne-Mendel rat), 760 formation by chlorine, and inhibition by chlorine dioxide, mechanism of action, 305 Cholinesterases brain, subchronic intoxication effects of diisopropyltluorophosphate at early developmental stages(rat), s204 Chromium effect on metallothionein concentration in major organs (rat), 473 Cimetidine effecton radiation-induced intestinal blood flow increase (dog), 597 Collagen lung content, measurement, 240 pathway, fibrosis-induced changes, review, 2 10 synthesis at cellular level, 2 19 in fibrosing organs, chemical mediators, 228 and processing, fibrosis development and assessment: symposium introduction, 207 Compound LY 17 I883 -induced liver enlargement, characterization (dog, guinea pig, hamster, monkey, mouse, rat), 794 Corticosterone serum levels after soman poisoning (mouse), S6 1 Cyanide acute intoxication, effectson central transmitter systems (rat), s150
SUBJECT INDEX Cyclohexanone oxime hematotoxicity after acute dermal exposure or subchronic oral exposure (rabbit, rat), 128 subacute oral exposure (rat), 117 Cyclophosphamide effect on antibody synthesis, interleukin 2 activity, and natural killer cell cytotoxicity in vivo and in vitro (rat), 158 Cytochrome P-450 interaction with trichloroethane isomers (perfused rat liver), 353 reconstituted purified preparations, -induced mutagenic activation and inactivation of carcinogens (rat liver), 487 Cytotoxicity diacetoxyscirpenol-induced, in brain, bone marrow, and adrenal glands atIer intravenous administration (swine), 1034 natural killer cell, effect of cyclophosphamide, lead, and polychlorinated biphenyls in vivo and in vitro (rat), 158 D
Decahn subchronic inhalation toxicity study (dog, mouse, rat), 785 Developmental toxicity chemical embryotoxins in workplace: recognition, evaluation, and control, 626 diisopropylfluorophosphate subchronic intoxication effects on brain cholinergic systemsat prenatal and postnatal stages (rat), S204 environmentally-induced human reproductive hazards, risk assessment:historical overview, 609 mechanistic models, 634 risk assessment symposium introduction, 607 with teratology data, FDA perspectives (human), 6 15 symposium summarization, 653 Dexamethasone protective effectsin sulfur and nitrogen mustard-induced toxicity (rat), S 160 Diacetoxyscirpenol acute toxicopathic effectsatIer intravenous administration (swine), 1034 Diaminodiphenoxybutane -induced visual toxicity (conscious dog), 777 Diazepam with pyridostigmine, pretreatment: protective effect on soman and sarin poisoning (guinea pig), S225 Dibenz[u,c]anthracene reconstituted cytochrome P-450-induced mutagenic activation and inactivation (rat liver), 487 o-Dichlorobenzene inhalation exposure, teratogenicity evaluation (rabbit, rat), 190
1197
pDichlorobenzene inhalation exposure, teratogenicity evaluation (rabbit), 190 2,CDichlorophenol acute and subchronic oral toxicity (mouse), 478 N-(Dichlorophenyl)nimide isomeric, acute nephrotoxicity (Sprague-Dawley, Fischer 344 rats), 1119 2,3Dichloropropene disposition atIer inhalation exposure, effect of vapor concentration (Fischer-344 rat), 997 Diesel exhaust inhalation exposure effects on immune responses atIer lung immunization (mouse, rat), 1075 Diet L-buthionine-S,R-sulfoximine-induced long-term glutathione depletion, effect on lung, liver, kidney, and blood (mouse), 9 13 cellulose fiber and phytic acid manipulation, effect on blood lead concentration (monkey), 588 commercial alkyldimethylamine oxides, two-year chronic feeding study (rat), 869 dioxin-induced weight loss, hypophagia role (guinea pig, mouse, rat), 700 mirex and chlordecone combination, effect on carbon tetrachloride hepatotoxicity (rat), 679 styrene monomer-treated drinking water, chronic toxicity and three-generation reproduction study (rat), 855 Diethylene glycol monobutyl ether, see Butyl carbitol Diethylene glycol monomethyl ether, see Methyl carbitol Diisopropylaminoethyl-methylphosphonothiolate poisoning, molecular basis for prophylaxis and treatment: multiple actions of anticholinesterase agents on chemosensitive synapses (rat), S 182 Diisopropylfluorophosphate acetylcholinesterase recovery in murine central nervous system reaggregate cultures after acute exposure, 1104 neurotoxic effectson neurohypophysis atIer single and multiple exposures (cat), 1087 subchronic intoxication effects on brain chohnergic systemsat early developmental stages (rat), S204 toxicity, tolerance development: mechanisms (rat brain, liver, muscle), S 17 Dimethylamine inhalation toxicity after chronic exposure (mouse, rat), 341 Dimethylmercury and glutathione, biliary secretion and hepatic transport (rat), 816 -induced mitochondrial DNA synthesisin neural tissue (cat), 25 1 uptake by kidney, role of glutathione, 832 Dinitrotoluene teratologic evaluation (timed-pregnant Fischer 344 rat), 948
1198
SUBJECT INDEX
a-( l,4-Dioxido-3-methylquinoxalin-2-yl)-~-methylmtrone -induced adrenal cortex degeneration (dog, rat), 370 Dioxin induction of aryl hydrocarbon hydroxylase in vitro (rat hepatocytes), 7 13 weight loss, hypophagia role (guinea pig, mouse, rat), 700 -like activity, in vitro bioassay based on epithelial cell proliferation and morphology changes (murine teratoma), 754 Dipropylene glycol monomethyl ether metabolism and disposition (rat), 72 I Disopyramide phosphate effect on serum glucose and ghtcose counterregulation (dog), 539 DNA synthesis mitochondrial, methyl mercury-induced (feline brain), 251 Dosage maximum tolerated, in carcinogenicity testing, definition and evaluation, 66 E
Ear central, arterial blood pressure: direct measurement technique in canine toxicity, evaluation, 39 I Embryotoxins in workplace: recognition, evaluation, and control, 626 Epinephrine plasma concentrations, changes after T-2 toxin administration (swine), 879 Epoxide hydrolase hepatic microsomal, methapyrilene effect (rat), 165 Erythrocytes filterability, ozone effect: clinical test of 0s toxicity (vitamin E-deficient, -supplemented mice), I37 N-D-omithyl amphotericin B methyl ester-induced toxicity, subchronic studies (dog, rat), 737 Ethambutol -induced visual toxicity (conscious dog), 777 Ethanol teratogenicity evaluation after inhalation exposure (rat), 727 Ethanolamine distribution and metabolism after topical application (human skin grafts; murine, porcine skin), S127 2-Ethoxyethyl acetate hydrolysis by nasal mucosal carboxylesterase in vitro (dog, mouse, rabbit, rat), 399 Ethyl acrylate hydrolysis by nasal mucosal carboxylesteram in vitro (dog, mouse, rabbit, rat), 399 Ethylene inhalation exposure, chronic toxicity and oncogenicity bioassay (Fischer-344 rat), Vol. 4, p. 473; letter to editor, 203; reply, 204
Ethylene glycol monoethyl ether acetate, see f-Ethoxyethyl acetate Ethylene glycol monomethyl ether, see Methyl cellosolve Ethylene glycol monomethyl ether acetate, see Methyl cellosolve acetate Excretion I-nitropyrene, after oral or intrapetitoneal administration (rat), 287 Eye retina and ocular fundus, diaminodiphenoxybutane, quinine, and ethambutol-induced toxicity (conscious dog), 777 F
FDA, see Food and Drug Administration Fenvalerate neurophatmacologic and neuropathologic effects, (mouse, rat), 278 Fibrosis collagen synthesis at cellular level, 2 19 in fibrosing organs, chemical mediators, 228 development and assessment:symposium introduction, 207 -induced changes in collagen pathway (review), 2 10 pulmonary collagen content quantitation, 240 fluoride acute toxicity, renal, hepatic, and metabolic effects (sheep), 1025 Foci hepatic atlatoxin Br-induced enzyme-altered, selenium effect (rat), 320 assay,and strain A mouse lung tumor assay, carcinogenicity testing: comparison (rat), 688 spontaneously occurring, quantitation (rat), 3 14 Food and Drug Administration perspective on use of teratology data for human risk assessment,6 15 Fungi Amanita virosa, cyclic peptides: hepatotoxic effectsafter acute intoxication (mouse), I 144 G G-418 oral dosing, effect on skin and mucous membrane ulceration (beagle dog), 986 Genotoxicity P+t-hydroxyphenyl)retinamide, assessment, 144 Gentamicin -induced biphasic hindlimb paralysis, histological and electrophysiological assessment(rat), 933 Gentian violet carcinogenicity and chronic toxicity (B6C3Fl mouse), 902
SUBJECT INDEX GestatiOll
dinitrotoluene administration, teratologic evaluation (Fischer 344 rat), 948 hexachlorobenzene placental transfer, and lactational transfer: comparative effectson maternal and neonate tissue levels (mouse), 265 Glutathione and glutathione-metal complexes, bihaty secretion and hepatic transport (rat), 8 16 lon@erm depletion, after Lbuthionine-S,R-sulfoximine administration, effect on lung, liver, kidney, and blood (mouse), 9 13 role in hepatotoxicity of organic and metallic compounds (rat), 806 mercury uptake by kidney, 832 toxicology of metals: symposium introduction, 805 H
Heart output, and blood pressure changes at&r T-2 toxin administration (swine), 879 metallothionein concentration, effectsof various metals (la), 473 Heparin protective effectsin sulfur and nitrogen mustard-induced toxicity (rat), s 160 Hepatocytes aryl hydrocarbon hydroxylase induction by chlorinated aromatic hydrocarbons in vifro (rat), 7 13 2,4,5,2’,4’,5’-Hexabromobiphenyl photolysis characterization, 546 products hepatotoxicity and microsomal enzyme induction (rat), 555 Hexachlorobenzene maternal and neonate tissue levels after placental or lactational transfer, comparison (mouse), 265 HI-6, see l-(2-Hydroxyiminomethylpyridinium~2-(4carboxyamid~pytidium)dimethyl ether dichloride Hindlimb paralysis, biphasic, gentamicin-induced: histological and electrophysiological assessment (tat), 933 HJ6 pretreatment, protective effect on satin- and soman-induced inhalation toxicity (rat), S84 Horseradish peroxidase respiratory tract absorption and plasma clearance kinetics (guinea pig), 99 Hydrazine long-term inhalation toxicity studies (dog, hamster, mouse, rat), 1050 Hydrogen chloride inhalation toxicity, evaluation by carbon dioxide challenges (guinea pig), 978 l-(2-Hydroxyiminomethylpyridinium)-2-(4-carboxyamido-pyridium)dimethy1 ether dichloride
1199
blood levels, urinary excretion, and tolerance after intramuscular administration (human), 89 N-(4-Hydroxyphenyl)mtinamide genotoxicity assessment, 144 1-[2-Hydroxy-3-propyl-4-[4-( lH-tetrazol-5-yl)-butoxy]phenyllethanone, see Compound LY 17 1883 Hydroxyurea and 5-bromodeoxyuridine, teratogenic interaction: examination by limb culture and image analysis (mouse), 1161 teratologic evaluation (timed-pregnant Fischer 344 rat), 948 Hypoglycemia disopyramide phosphate-induced, and glucose counterregulation (dog), 539 Hypophagia role in dioxin-induced weight loss (guinea pig, mouse, rat), 700 I Immune responses antibody synthesis and interleukin 2 activity, effect of cyclophosphamide, lead, and polychlorinated biphenyls in vivo and in vitro (rat), 158 aBer lung immunization, diesel exhaust inhalation exposure effects (mouse, rat), 1075 Indecainide hydrochloride acute toxicity and 3-month subchronic toxicity studies (dog, monkey, mouse, rat), 175 Inhalation toxicity ammonia- or ozone-induced, effects on behavior (mouse, rat), 1110 asbestos, short fibers, after chronic exposure (monkey, rat), 327 bronchordveolar lavage Iluid analysis, pulmonary toxicity evaluation, 45 1 decalin a&r subchronic exposure (dog, mouse, rat), 785 2,3dichloropropene, vapor concentration effect on disposition (Fischer-344 rat), 997 diesel exhaust particles, chronic effects on immune responsesafter lung immunization (mouse, rat), 1075 dimethylamine after chronic exposure (mouse, rat), 34 1 bronchoalveolar lavage fluid analysis, evaluation, 45 1 hydrazine, long-term exposure effects (dog, hamster, mouse, rat), 1050 hydrogen chloride, evaluation by carbon dioxide challenges (guinea pig), 978 methanol and ethanol, teratogenicity evaluation (rat), 727 methyl carbitol, 13-week study (rat), 1174 monochlorodiisobutylene after acute and short-term exposure (mouse, rat), 506 mpiratoly tract clearance, mechanisms and measurement techniques (review), 435 morphological evaluation (review), 405
1200
SUBJECT INDEX
satin and soman, protective effectof oxime pretreatment (rat), s&l toluene, effects on carbon dioxide production and locomotor activity (mouse), 971 Intestines blood flow, radiation-induced increase: antihistamine effect (dog), 597 metallothionein concentration, effectsof various metals (rat), 473 transport, methotrexate effects (rat), 991 Iodide absorption and distribution after dietary exposure, chlorine dioxide effect (rat), 672 Iron effect on metallothionein concentration in major organs (rat), 473 K
6-Keto-prostaglandin F,, plasma concentrations, changes after T-2 toxin administration (swine), 879 Kidney cephaloridine toxicity: strain and sex differences (mouse), I 153 chlorodibromomethane toxicity and carcinogenic&y (B6C3Fl mouse, Fischer 344 rat), 1128 chloroform-induced carcinogenicity (Osborne-Mendel rat), 760 chronic toxicity of styrene monomer administration in drinking water (rat weanling), 855 function, effect of acute sodium fluoride poisoning (sheep), 1025 isomeric iV-@ichlorophenyl)nimide acute toxicity (Sprague-Dawley, Fischer 344 rats), 1119 long-term glutathione depletion effectsafter Lbuthionine-S,R-sulfoximine administration (mouse), 9 13 mercury uptake, role of glutathione, 832 metallothionein concentration, effectsof various metals (rat), 473 N-wrnithyl amphotericin B methyl ester-induced toxicity, subchronic studies (dog, rat), 737 stirofos oncogenicity evaluation (B6C3Fl mouse), 840 L
Lactation hexachlorobenzene exposure, and placental transfer: comparative eflhcts on maternal and neonate tissue levels (mouse), 265 Lead blood levels, diet effect (monkey), 588 effect on antibody synth~ interleukin 2 activity, and natural killer cell cytotoxicity in vivo and in vitro (rat), 158 metallotbionein concentration in major organs (rat), 473
Lethal dose (LD50) values upanddown procedure, development and statistical evaluation, 15 I Liver aflatoxin Bi-induced enzyme-altered foci, selenium effect (rat), 320 bromobenzene-induced toxicity, zinc protective effect, mechanism of action (rat), 297 carbon tetrachloride-induced toxicity, mirex and chlordecone effects after dietary exposure (rat), 679 chlorodibromomethane toxicity and carcinogenicity (B6C3Fl mouse, Fischer 344 rat), 1128 chloroform-induced carcinogenicity (B6C3Fl mouse), 760 chronic toxicity of styrene monomer administration in drinking water (rat weanling), 855 cytochrome P-450, interaction with trichloroethane isomers in vitro (rat), 353 diisopropylfhtorophosphate toxicity, tolerance development: mechanisms (rat), S I7 enlargement, compound LY 17 1883-induced, charao terization (hamster, mouse, rat), 794 fibrosis-induced changes in collagen pathway, review, 210 foci assay,and strain A mouse lung tumor assay, carcinogenicity testing: comparison (rat), 688 function, effect of acute sodium fluoride poisoning (sheep), 1025 glutathione metabolism and transport of metals to bile, analysis (rat), 8 16 hepatocytes, see Hepatocytes 2,4,5,2’,4’,5’-hexabromobiphenyl photolysis productinduced toxicity and microsomal enzyme response (rat), 555 long-term glutathione depletion effectsafter Lbuthionine-S,R-sulfoximine administration (mouse), 9 13 metallothionein concentration, effectsof various metals (rat), 473 monochlorobenzene-induced toxicity, dose-response and temporal characteristics (rat), 105 morphology and xenobiotic-metabolizing enzymes, methapyrilene effects (rat), 165 N-D-ornithyl amphotericin B methyl ester-induced toxicity, subchronic studies (dog, rat), 737 phalloidin and virotoxin effectsafter acute intoxication (mouse), 1144 reconstituted cytochrome P-450-induced mutagenic activation and inactivation ofcarcinogens (rat), 487 spontaneously occurring foci of cellular alteration, quantitation (rat), 3 14 stirofos oncogenicity evaluation (B6C3Fl mouse), 840 toxicity of organic and metallic compounds, role of glutathione (rat), 806 Lung, see also Respiratory tract bronchoalveolar lavage fluid, analysis for pulmonary toxicity evaluation, 45 1 diesel exhaust inhalation exposure effects on immune responses after immunization (mouse, rat), 1075
SUBJECT INDEX
changes in collagen pathway, review, 210 collagen synthesis, quantitation, 240 function in rodents, measurement techniques, 423 hydrogen chloride inhalation toxicity, evaluation by carbon dioxide challenges (guinea pig), 978 long-term ghttathione depletion effectsafter Lbuthionine-S,R-sulfoximine administration (mouse), 9 I3 metallothionein concentration, effectsof various metals (rat), 473 triethyl and trimethyl phosphorothioate toxicity (rat), S47 tumor assay,and rat hepatic foci assay:carcinogenicity testing: comparison (strain A mouse), 688 Lymph nodes pulmonary, diesel exhaust inhalation exposure effects after immunization (mouse, rat), 1075 M
Manganese effecton metallothionein concentration in major organs (rat), 473 Mecamylamine with atropine or physostigmine, pretreatment effect on sarin and VX poisoning (rat), S 182 Meclofenamate sodium effect on fertility and teratogenic evaluation (rat), 665 Membranes mucous, ulceration after G-4 I8 oral dosing (beagle dog), 986 Mepyramine effecton radiation-induced intestinal blood tlow increase (dog), 597 Mercury effecton metallothionein concentration in major organs (rat), 473 inorganic, and ghttathione, bii secretion and hepatic transport (rat), 8 I6 uptake by kidney, role of ghnathione, 832 Metabolism caffeine, after chronic consumption (female monkey), 578 carbon dioxide production as index (mouse), 962 and disposition dipropylene glycol monomethyl ether (rat), 72 I I-nitropyrene, after oral or intraperitoneal administration (rat), 287 effect of acute sodium tluoride poisoning (sheep), 1025 ethanolamine, at&r topical application (human skin grafts; murine, porcine skin), S127 Metallothionein concentration in major organs, effectsof various metals (rat), 473 Metals toxicity, uptake, and elimination, role of ghrtathione: symposium introduction, 805
1201
Methanol teratogenicity evaluation after inhalation exposure (rat), 727 Metbapyrilene effect on hepatic epoxide hydrolase and cytochrome P450dependent mixed-function oxidases, liver morphology, and liver-derived serum enzymes (rat), 165 Methotrexate effects on intestinal transit (rat), 99 I Methyl acrylate hydrolysis by nasal mucosal carboxylesterase in vitro (dog, mouse, rabbit, rat), 399 Methyl carbitol inhalation toxicity, 13-week study (rat), 1174 Methyl cellosolve effect on mating performance, epididymal spermatids, and spermatogonia (rat), 182 testicular recovery after short-term dosing: histology, cell-specific enzymes, and rete testis fluid protein (rat), 5 15 Methyl cellosolve acetate hydrolysis by nasal mucosal carboxylesterase in vitro (dog, mouse, rabbit, rat), 399 Methyl chloride effect on reproduction after inhalation exposure, twogeneration study (rat), 568 neurotoxicity, effect of continuous or intermittent exposure (C57BL/6 mouse), 87 pharmacokinetics after inhalation exposure (human), 361 Methyl mercury, see Dimethylmercury Methylpyridines, see Picolines Mirex and chlordecone combination, effect on carbon tetrachloride hepatotoxicity after dietaty exposure (rat), 679 Mixed-function oxidases, see Oxidases Models animal, see Animal models mechanistic, developmental toxicity risk assessment,634 skin development of rat/human sandwich flap served by defined and accessible vasculature on athymic rat, s112 toxicity testing, development, S98 Monochlorobenxene, see Chlorobenxene Monochlorodiisobutylene inhalation toxicity after acute and short-term exposure (mouse, rat), 506 Monosodium cyanurate mutagenicity evaluation in vitro and in vivo (Chinese hamster cells, murine lymphoma cells, rat), 655 Muscles diaphragm, extensor digitorum longus, and soleus: acute and subchronic pyridostigmine bromide exposure effects(rat), S260
1202
SUBJECT INDEX
skeletal, diisopropyltluorophosphate toxicity, tolerance development: mechanisms (rat), Si 7 Mustard gas -induced w&cation, molecular basis (human skin), S 134 sulfur and nitrogen, toxicity: protective effectsof dexamethasone, promethazine, vitamin E, heparin, and sodium thiosulfate (rat), S 160 Mutagenicity bmminated and chlorinated acetonitriles formed during chlorination of drinking water, 1065 monosodium cyanurate, evaluation in vitro and in vivo (Chinese hamster cells, murine lymphoma cells, rat), 655 N
National Cancer Institute carcinogenesis testing program: history, survival, and growth patterns of B6C3Fl mice and F344 rata, 526; erralum, 1188 Nerve agents patbology: perspectives on medical management, SlO Nemotoxicity diisopropylfluorophosphate and soman in neurohypophysis after single and multiple exposures (cat), 1087 fenvalerate-induced peripheral nerve fiber damage, and pharmacologic effect (mouse, rat), 278 gentamicin, induction of biphasic hindlimb paralysis: histological and electrophysiological assessment (rat), 933 methyl chloride, effect of continuous or intermittent exposure (C57BL/6 mouse), 87 pyridostigmine bromide acute and subchronic exposure in diaphragm, extensor digitorum longus, and soleus muscles (rat), S260 soman in brain and spinal cord (hen), S 180 Neurotoxicology acute exposure to (Y-,@-.and y-picoline (rat), 920 kindling and kindled seizures, drug and chemical effects, 41 neurophysiological techniques for evaluation of pyrethroid mechanism of action, in vifro and in vivo correlations, 9 toxic effectsand mechanisms of action at single neuronal systemic level, symposium introduction, 1 sensory evoked potentials, use in toxicity screening and determination of affected neural system, 24 Nickel effecton metallotbionein concentration in major organs (rat), 473 Z-Nitrofluorene reconstituted cytochrome P-450-induced mutagenic activation and inactivation (rat liver), 487 I-Nitropymne excretion and metabolism after oral or intraperitoneal administration (rat), 287
Norepinephrine plasma concentrations, changes after T-2 toxin administration (swine), 879 Nose mucosal tissue carboxylesterase, hydrolysis of glycol ether acetates and acrylate esters (dog, mouse, rabbit, rat), 399 olfactory sensory cells, effect of chronic dimethylamine inhalation exposure (mouse, rat), 341 0 Obidoxime chloride pretreatment, protective effect on satin- and soman-induced inhalation toxicity (rat), S84 Oncogenicity stirofbs in liver and kidney, evaluation (B6C3Fl mouse), 840 N-DOmithyl amphotericin B methyl ester subchronic toxicity studies (dog, rat), 737 Orthodichlorobenzene, see o-Dichlorobenzene Oxidases mixed-function, cytochrome H50dependent, methapyrilene effect (rat liver), 165 Oximes pretreatment, protective effect on satin- and soman-induced inhalation toxicity (rat), S84 Ozone effect on erythrocyte filterability as test of 0s toxicity (vitamin E-deficient, -supplemented mice), 137 -induced behavioral changes after inhalation exposure (mouse, rat), 1110 P Pancreas metallothionein concentration, effectsof various metals (rat), 473 Paradichlorobenzene, see pDichlorobenzene Paralysis biphasic hindlimb, gentamicin-induced: histological and electrophysiological assessment (rat), 933 Paraoxon tolerance, assessmentof behaviorally augmented component: role of reinforcement and response factors (la), s2 13 Petroleum hydrocarbons complex mixtures, Salmonella/microsome mutagenesis assayand murine dermal caminogenesis bioassay, comparison, 382 Phalloidin hepatotoxicity after acute intoxication (mouse), 1144 Pharmaceuticals from England, chronic animal toxicology studies, retrospective analysis, 1007 Pharmacokinetics 2,3dichloropropene after inhalation exposure, vapor concentration effect (Fischer-344 rat), 997
1203
SUBJECT INDEX ethanolamine after topical application (human skin grafts; murine, porcine skin), S127 HI-6 after intramuscular administration (human), S89 methyl chloride atIer inhalation exposure (human), 361 soman stereoisomers (mutine blood, tissues), S252 triethyl and trimethyl phosphorothioates (rat), S47 Physostigmine pretreatment effect on satin and VX poisoning (rat), S182 Picolines a-, /3-, and y-, acute exposure, neurophysiological consequences (rat), 920 Pituitary gland neurohypophysis, diisopropylfluorophosphate and soman neurotoxic effects after single and multiple exposures (cat), 1087 Plasma acid-base parameters, changes after T-2 toxin administration (swine), 879 ACTH levels after soman poisoning (mouse), S6 1 catecholamines, 6-keto-prostaglandin F,,, and thromboxane Br levels, T-2 toxin-induced changes (swine), 879 horseradish peroxidase clearance kinetics (guinea pig), 99 soman in vitro detoxification (human), S175 Pralidoxime chloride and atropine and soman interactions, application of response-surfacemodeling for evaluation (guinea pig), S232 Pralidoxime mesylate with pyridostigmine, pretreatment: protective effect on soman and satin poisoning (guinea pig), S225 Promethazine protective effectsin sulfiir and nitrogen mustard-induced toxicity (rat), Sl60 Propylene glycol monomethyl ether acetate hydrolysis by nasal mucosal carboxylesterase in vitro (dog, mouse, rabbit, rat), 399 Pyrethroids, see also specijic pyrethroids mechanism of action, in vitro and in vivo correlations, neurophysiological evaluation, 9 Pyridostigmine with atropine, pralidoxime mesylate, and diaxepam, pretreatment: protective effect on soman and satin poisoning (guinea pig), S225 Pyridostigmine bromide acute and subchronic exposure: neuromuscular toxicity in diaphragm, extensor digitorum longus, and soleus muscles (rat), S260 pretreatment effectson soman intoxication, evaluation by response-surface modeling (guinea pig), S242 Q Quinine -induced visual toxicity (conscious dog), 777
R Radiation -induced intestinal blood flow increase, antihistamine effect (dog), 597 Reproduction egg maturation and spawning, effect on 2,5,2’,5’-tetrachlorobiphenyl distribution and elimination (female yellow perch), 770 mating performance and epididymal spermatids and spermatogonia: ethylene glycol monomethyl ether effects (rat), 182 after styrene monomer administration in drinking water, three-generation study (rat), 855 Reproductive toxicity butyl carbitol, evaluation (rabbit, rat), 1137 meclofenamate sodium (rat), 665 methyl chloride alter inhalation exposure, two-generation study (rat), 568 potential indicators: testicular sperm production and epididymal sperm number, transit time, and motility (male Fischer 344 rats), 1097 Respiratory tract, see also Lung clearance mechanisms and measurement techniques (review), 435 horseradish peroxidase absorption kinetics (guinea pig), 99 immediate- and delayed-onset pulmonary hypcrsensitivity, animal models: immunotoxicologic evaluation, 459 structural evaluation for inhalation toxicity studies (review), 405 Response-surface modeling evaluation of pyridostigmine bromide pmtmatment effects in soman intoxication (guinea pig), S242 soman, atropine, and pralidioxime chloride interao tions (guinea pig), S232 Risk assessment carcinogens, extrapolation from mouse and rat bioassays,evaluation of interspecies correlation studies of carcinogenic potency, 79 chemical embryotoxins in workplace: recognition, evaluation, and control, 626 developmental toxicity mechanistic models, 634 symposium introduction, 607 environmentally-induced human reproductive hazards: historical overview, 609 G-4 18, effecton skin and mucous membrane ulceration: acute oral toxicity study (beagle dog), 986 gentian violet, evaluation in liver, linear extrapolation to virtually sate dose (B6C3Fl mouse), 902 pharmaceutical compounds from England, chronic animal toxicology studies: retrospective analysis, 1007 teratogenic hazards, symposium summarization, 653 use of teratology data, FDA perspectives (human), 6 I5
1204
SUBJECT INDEX S
Satin acute toxicity, behavioral analysis (marmoset), S169 inhalation toxicity, protective effect of oxime pretreatment (rat), S84 poisoning molecular basis for prophylaxis and treatment: multiple actions of anticholinesterase agents on chemosensitive synapses (rat), S 182 protective effect of pyridostigmine pretreatment with atropine, pralidoxime mesylate, and diazepam (guinea pig), S225 seizure pathology: perspectiveson medical management, SIO S&W3
kindled, drug and chemical effects,4 1 satin- and soman-induced, pathology: perspectives on medical management, SlO Selenium effect on emergence of aflatoxin Br-induced enzymealtered hepatic foci (rat), 320 Serum corticosterone, thyroxine, triiodothyronine, and testosterone levels after soman poisoning (mouse), S6 1 enzymes and biochemistry, effect of intravascular T-2 toxin (female swine), 893 Sex differences cephaloridine nephrotoxicity (mouse), 1153 Skin commercial alkyldimethylamine oxide administration, two-year chronic study (mouse), 869 flap, rat/human, served by defined and accessible vasculature on athymic rat, development, S I 12 models for toxicity testing, development, S98 mustard gas-induced vesication, molecular basis (human), S 134 toxicity testing, model development, S98 ulceration after G-4 18 oral dosing (beagle dog), 986 Sodium thiosulfate protective effectsin suhiu and nitrogen mustard-induced toxicity (rat), S 160 Soman and atropine and prahdioxime interactions, application of response-surfacemodeling for evaluation (guinea pig), S232 and BM 123, synergistic effects(rat), S78 dermatotoxicity, model development, S98 detoxification, role of carboxylesterases (rat), S29 inhalation toxicity, protective effect of oxime pretreatment (rat), S84 intoxication pyridostigmine bromide pretreatment effects: evaluation by response-surface modeling (guinea pig), S242 role of brain capillaries as blood-brain barrier (rabbit), s122
neurotoxic effectsin brain and spinal cord (hen), S180 neurohypophysis after single and multiple exposures (cat), 1087 in plasma, in vitro detoxification (human), S175 poisoning hormonal consequences (mouse), S61 protective effect of pyridostigmine pretreatment with atropine, prahdoxime mesylate, and diazepam (guinea pig), S225 seizure pathology: perspectiveson medical management, SlO stereoisomers, distribution and elimination and effect on brain acetylcholine (murine blood, tissues),S252 Spinal cord gentamicin-induced paralysis in biphasic hindlimb: histological and electrophysiological assessment(rat), 933 neuropathic effect of soman (hen), S180 Spleen metahothionein concentration, effectsof various metals (rat), 473 Stirofos oncogenic evaluation (B6C3Fl mouse), 840 Stomach iodide absorption and distribution, chlorine dioxide effect (rat), 672 metallothionein concentration, effectsof various metals (la), 473 Strain differences cephaloridine nephrotoxicity (mouse), 1153 Styrene monomer -treated drinking water, chronic toxicity and three-generation reproduction study (rat), 855 Synergism between soman and N4(2-Chloroethylamino~2-butynyl-2-pyrollidine (rat), S78 T
TCDD, see Dioxin Teratogenicity butyl carbitol, evaluation (rabbit, rat), I 137 data for human risk assessment: FDA perspectives on use, 615 dichlorobenzenes alter inhalation exposure (rabbit, rat), 190 environmental chemicals, risk assessment, historical overview (human), 609 ethanol and methanol, evaluation after inhalation exposure (rat), 727 hydroxyurea administration in timed-pregnant Fischer 344 rats, 948 interaction of hydroxyurea and 5-bromodeoxyuridine, examination by limb culture and image analysis (mouse), I161
SUBJECT INDEX
1205
meclofenamate sodium, evaluation (rat), 665 chronic feeding and dermal studies (mouse, rat), 869 Testes pulmonary hmction in rodents, measurement techmetallothionein concentration, effectsof various metals niques, 423 (rat), 413 skin models, development, S98 recovery after short-term ethylene glycol monomethyl ether dosing: histology, cell-specific enzymes, and Toxogonin, see Obidoxime chloride rete testis 5uid protein (rat), 5 15 1,1,l -Trichloroethane sperm production and epididymal sperm number, interaction with cytochrome P-450 (perfused rat liver), transit time, and motility: potential indicators of 353 reproductive toxicity (Fischer 344 rats), 1097 1,1,2-Trichloroethane Testosterone interaction with cytochrome P-450(perfused rat liver), serum levels after soman poisoning (mouse), S6 1 353 2,5,2’,5’-Tetrachlorobiphenyl Trichothecenes distribution and elimination after chronic exposure, detoxification, role of carboxylesterases (rat), S29 spawning effect (female yellow perch), 770 Triethyl phosphorothioates 2,3,7,8-Tetrachlorodibenzo-p-dioxin, see Dioxin phannacokinetics and pulmonary toxicity (rat), S47 Tetrachloninphos, see Stirofos Triiodothyronine Thromboxane Bs serum levels after soman poisoning (mouse), S6 1 plasma concentrations, changes after T-2 toxin adminTrimethyl phosphorothioates istration (swine), 879 pharmacokinetics and pulmonary toxicity (rat), S47 Thyroxine T-2 toxin serum levels after soman poisoning (mouse), S6 1 intravascular administration, effect on Tolerance cardiac output, blood pressure, catecholamines, 6diisofluorophosphate, toxicity, development: mechaketo-prostagIandin F,,, thromboxane Br,, and acidnisms (rat brain, liver, muscle), S 17 base parameters (swine), 879 HI-6, after intramuscular administration (human), S89 serum enzymes and biochemistry, blood coagulation, paraoxon, assessmentof behaviorally augmented comand hematology (female swine), 893 ponent: role of reinforcement and response factors (rat), S2 13 Toluene U inhalation effectson carbon dioxide production and locomotor activity (mouse), 97 1 Urine Toxicity HI-6 excretion after intramuscular administration (huacute, oral: G-4 18 effectson skin and mucous membrane man), S89 ulceration (beagle dog), 986 chronic, gentian violet (B6C3Fl mouse), 902 metals, role of glutathione: symposium introduction, V 805 organophosphorus anticholinesterases and trichotheVesication cenes, role of carboxylesterases in detoxification mustard gas-induced, molecular basis (human skin), (rat), S29 s134 sarin and soman, protective effect of pyridostigmine Virotoxins pretreatment with atropine, pralidoxime mesylate, hepatotoxicity after acute intoxication (mouse), 1144 and diazepam (guinea pig), S225 Vitamin E sulfur and nitrogen mustard-induced, protective effects protective effectsin sulfur and nitrogen mustard-induced of dexamethasone, promethazine, vitamin E, heg toxicity (rat), S 160 arm, and sodium thiosulfate (rat), S160 VX, see Diisopropylamineothyl-methylphosphonothiolate Toxicity testing baseline clinical pathology parameters, variations: effect of blood sampling site and collection method (Fischer 344 rat), 1180 Zinc canine, direct blood pressure measurement, evaluation, effect on metallothionein concentration in major organs 391 chronic animal, pharmaceuticals from England, retro(rat), 473 spective analysis, 1007 protective effecton bromobenzene hepatotoxicity (rat), 297 commercial alkyldimethylamine oxides, two-year
AND
APPLIED
TOXICOLOGY
5, 1194-l
205 ( 1985)
Subject Index for Volume 5 A
Acetaminophen hepatotoxicity, role of glutathione (rat), 806 Acetonitriles brominated and chlorinated, formed during chlorination of drinking water: mutagenic and carcinogenic properties, evaluation, 1065 Acetylcholine brain, effect of soman stereoisomers (murine blood, tissues), S252 Acetylcholine receptors nicotinic, molecular structure and functional aspects, s39 Acetylcholinesterase in central nervous system reaggregate cultures, recovery after acute diisopropylfluorophosphate exposure (mouse), 1104 in isolated brain capillaries, role in soman intoxication (rabbit), S 122 ACTH, see Adrenocorticotropin Adrenal gland cortex, degeneration by a-( I ,4dioxido-3-methylquinoxalin-2-yl)-N-methylnitrone (dog, rat), 370 diacetoxyscirpenol-induced cytotoxicity after intravenous administration (swine), 1034 Adrenocorticotropin plasma levels after soman poisoning (mouse), S6 1 Aflatoxin B, -induced enzyme-altered hepatic foci, selenium effect (rat), 320 reconstituted cytochrome P-450-induced mutagenic activation and inactivation (rat liver), 487 Alkyldimethylamine oxides commercial, toxicological evaluation: two-year chronic feeding and dermal studies (mouse, rat), 869 o-Aminoazotoluene reconstituted cytochrome P-450-induced mutagenic activation and inactivation (rat liver), 487 2-Aminofluorene reconstituted cytochrome P-450~induced mutagenic activation and inactivation (rat liver), 487 Ammonia -induced behavioral changes after inhalation exposure (mouse, rat), 1110 Anguidine, see Diacetoxyscirpenol Animal models immediate- and delayed-onset pulmonary hypersensitivity, immunotoxicologic evaluation of respiratory system,459 National Cancer Institute carcinogenesis testing program: history, survival, and growth patterns of B6C3Fl mice and F344 rats, 526; erratum, 1188 0272-0590/85 $3.00 Copyright Q 1985 by the Society of Toxicology. All rights of reproduction in any form reserved.
rodents, pulmonary function, measurement techniques, 423 Announcements Fourteenth International Cancer Congress, Budapest, August 1986,605 Fourth Annual Meeting of American Association for Aerosol Research, Albuquerque, November 1985, 804 Fourth International Conference on Neurotoxicology of Selected Chemicals: Neurotoxicology in the Fetus and Child, Little Rock, Arkansas, September 1985,205 Sixteenth Congress of International Academy of Pathology and Seventh World Congress of Academic and Environmental Pathology, Vienna, August 1986,605 Symposium on Animal Carcinogenicity Studies, Bethesda, Maryland, March 1985,206 Anticholinestemses multiple actions on chemosensitive synapses:molecular basis for prophylaxis and treatment of organophosphate poisoning (rat), S182 noncholinergic actions: present and future development, review, S270 Aroclor 1254 effect on antibody synthesis, interleukin 2 activity, and natural killer cell cytotoxicity in vivo and in vitro (rat), 158 induction of aryl hydrocarbon hydroxylase in vitro (rat hepatocytes), 7 13 Arsine hematological exposure-response quantitation (mouse), 499 Aryl hydrocarbon hydroxylase induction by chlorinated aromatic hydrocarbons in vitro (rat hepatocytes), 7 13 2’,4’,5’-hexabromobiphenyl photolysis products (rat hepatocytes), 555 Asbestos chrysotile short fibers, chronic inhalation study (monkey, rat), 327 Atropine with oximes, pretreatment: protective effect on sarinand soman-induced inhalation toxicity (rat), S84 pretreatment effect on sarin and VX poisoning (rat), S182 with pyridostigmine, pretreatment: protective effect on soman and sarin poisoning (guinea pig), S225 and soman and prahdioxime chloride interactions, ag phcation of response-surface modeling for evahration (guinea pig), S232
1194
SUBJECT INDEX B
Behavior -augmented component of paraoxon tolerance, assessment: role of reinforcement and response factors (rat), S213 locomotor activity, and carbon dioxide production as index (mouse), 962 toluene inhalation effects (mouse), 97 1 visuomotor coordination, feeding, and locomotor activity: acute toxicity of satin (marmoset), S169 wheel running, ammonia and ozone inhalation exposure effects (mouse, rat), 1110 Benzo[a]pyrene reconstituted cytochrome P-450-induced mutagenic activation and inactivation (rat liver), 487 Bile secretion, and hepatic transport, glutathione and glutathione-metal complexes (rat), 8 16 Bioassays carcinogens, National Cancer Institute program: histoty, survival, and growth patterns of B6C3Fl mice and F344 rats, 526; erratum, 1188 chronic, statistical design recommendations, letter to the editor, 1186; response to letter, 1187 dioxin-like activity based on epithelial cell proliferation and morphology changes (murine teratoma), 754 murine dermal carcinogenesis, and Salmonella/microsome mutagenesis assay: comparative evaluation of complex petroleum hydrocarbon mixtures, 382 Blood amine exposure-response quantitation (mouse), 499 coagulation and hematology, effect of intravascular T2 toxin (female swine), 893 cyclohexanone oxime-induced toxicity after acute dermal exposure or subchronic oral exposure (rabbit, rat), 128 subacute oral exposure (rabbit, rat), 117 erythrocytes, see Erythrocytes HI-6 levels after intramuscular administration (human), S89 intestinal tlow, radiation-induced increase: antihistamine effect (dog), 597 lead concentration, diet effect (monkey), 588 long-term glutathione depletion effectsafter L-buthionine-S,R-sulfoximine administration (mouse), 913 sampling site and collection method, effecton variations in baseline clinical pathology parameters (Fischer 344 rat), 1180 serum glucose and glucose counterregulation, disopyramide phosphate effect (dog), 539 Blood-brain barrier function of isolated brain capillaries, role in soman intoxication (rabbit), S 122 Blood pressure direct measurement technique in canine toxicity, evaluation, 39 1 T-2 toxin-induced changes (swine), 879
1195
BM 123, see Wl-(2Chloroethylamino)-2-butynyl-2-pyrollidine Bone marrow diacetoxyscirpenol-induced cytotoxicity after intravenous administration (swine), 1034 Brain acetylcholine, effect of soman stereoisomers (murine blood, tissues), S252 cerebellum and cerebrum, mitochondrial DNA synthesis, induction by methyl mercury (cat), 25 1 cholinergic systems, subchronic intoxication effects of diisopropyllluorophosphate at early developmental stages (rat), s204 diacetoxyscirpenol-induced cytotoxicity after intravenous administration (swine), 1034 diisopropylfluorophosphate toxicity, tolerance development: mechanisms (rat), St 7 isolated capillaries, role as blood-brain barrier in soman intoxication (rabbit), S122 metallothionein concentmtion, effects of various metals (rat), 473 neuropathic effect of soman (hen), S 180 neurotransmitter systems, acute cyanide intoxication effects(rat), S 150 N-D-omithyl amphotericin B methyl ester-induced morphologic changes, subchronic toxicity studies (dog), 737 satin- and soman-induced seizures, pathology: perspectives on medical management, SlO Bromobenzene hepatotoxicity role of glutathione (rat), 806 zinc protective effect, mechanism of action (rat), 297 5-Bromodeoxyuridine and hydroxyurea, teratogenic interaction: examination by limb culture and image analysis (mouse), 116 1 L-Buthionine-S,R-sulfoximine -induced long-term glutathione depletion, effecton lung, liver, kidney, and blood (mouse), 9 13 Butyl acrylate hydrolysis by nasal mucosal carboxylesterase in vitro (dog, mouse, rabbit, rat), 399 Butyl carbitol reproductive toxicity and teratogenicity (rabbit, rat), 1137 C Cadmium effecton metallothionein concentration in major organs (rat), 473 hepatotoxicity, role of glutathione (rat), 806 Caffeine metabolic fate after chronic consumption (female monkey), 578 Carbon dioxide challenges, evaluation of hydrogen chloride inhalation toxicity (guinea pig), 978
1196
SUBJECT INDEX
production as index of behavioral and metabolic activity (mouse), 962 and locomotor activity, toluene inhalation effects (mouse), 97 1 Carbon tetrachloride hepatotoxicity, effect of mirex and chlordecone dietary exposure (rat), 679 Carboxylesterases nasal mucosal, hydrolysis of glycol ether acetates and acrylate esters (dog, mouse, rabbit, rat), 399 role in detoxification of organophosphorus anticholinesterases and trichothecenes (rat), S29 Carcinogenicity brominated and chlorinated acetonitriles formed during chlorination of drinking water, 1065 chlorodibromomethane, evaluation (B5C3F mouse), 1128 chloroform in drinking water (B6C3Ft mouse.,OsbomeMendel rat), 760 gentian violet (B6C3Fl mouse), 902 stirofos in liver and kidney, evaluation (B6C3Fl mouse), 840 styrene monomer administration in drinking water, three-generation reproduction study (rat), 855 Carcinogenicity testing commercial alkyldimethylamine oxides, two-year chronic feeding and dermal studies (mouse, rat), 869 maximum tolerated dose, definition and evaluation, 66 with mice and rats, correlation studies of carcinogenic potency, evaluation for risk estimation, 79 National Cancer Institute bioassay program: history, survival, and growth patterns of B6C3Fl mice and F344 rats, 526; erratum, 1188 petroleum hydmcarbon complex mixtures, comparative evaluation: SalmoneIa/microsome mutagenesis assayand murine dermal carcinogenesis bioassay, 382 rat hepatic foci assay and strain A mouse lung tumor assay,comparison (review), 688 Catecholamines plasma concentrations, changes after T-2 toxin administration (swine), 879 Cell culture limb explants, examination of hydroxyurea and 5-bromodeoxyutidine teratogenic interactions (mouse), 1161 Central nervous system reaggregate cultures, acetylcholinesterase recovery after acute diisopropylfluorophosphate exposure (mouse), 1104 Cephaloridine nephrotoxicity: strain and sex differences (mouse), 1153 Chemical poisoning prophylaxis and treatment, symposium introduction, Sl
Chlordecone and mirex combination, effect on carbon tetrachloride hepatotoxicity after dietary exposure (rat), 679 Chlorination drinking water, formed brominated and chlorinated acetonitriles: mutagenic and carcinogenic properties, evaluation, 1065 Chlorine formation of chloroform, and inhibition by chlorine dioxide, mechanism of action, 305 Chlorine dioxide effect on dietary iodide absorption and distribution (rat), 672 inhibition of chloroform formation, 305 Chlorisondamine with atropine or physostigmine, pretreatment effect on sarin and VX poisoning (rat), S 182 Chlorobenzene hepatotoxicity, dose-response and temporal characteristics (rat), 105 Chlorodibromomethane carcinogenicity and hepatic and renal toxicity (B6C3F1 mouse, Fischer 344 rat), 1128 N-4-(2-Chloroethylamino)-2-butynyl-2-pyrollidine and soman, synergistic effects(rat), S78 Chloroform in drinking water, carcinogenicity evaluation (B6C3Fl mouse, Osborne-Mendel rat), 760 formation by chlorine, and inhibition by chlorine dioxide, mechanism of action, 305 Cholinesterases brain, subchronic intoxication effects of diisopropyltluorophosphate at early developmental stages(rat), s204 Chromium effect on metallothionein concentration in major organs (rat), 473 Cimetidine effecton radiation-induced intestinal blood flow increase (dog), 597 Collagen lung content, measurement, 240 pathway, fibrosis-induced changes, review, 2 10 synthesis at cellular level, 2 19 in fibrosing organs, chemical mediators, 228 and processing, fibrosis development and assessment: symposium introduction, 207 Compound LY 17 I883 -induced liver enlargement, characterization (dog, guinea pig, hamster, monkey, mouse, rat), 794 Corticosterone serum levels after soman poisoning (mouse), S6 1 Cyanide acute intoxication, effectson central transmitter systems (rat), s150
SUBJECT INDEX Cyclohexanone oxime hematotoxicity after acute dermal exposure or subchronic oral exposure (rabbit, rat), 128 subacute oral exposure (rat), 117 Cyclophosphamide effect on antibody synthesis, interleukin 2 activity, and natural killer cell cytotoxicity in vivo and in vitro (rat), 158 Cytochrome P-450 interaction with trichloroethane isomers (perfused rat liver), 353 reconstituted purified preparations, -induced mutagenic activation and inactivation of carcinogens (rat liver), 487 Cytotoxicity diacetoxyscirpenol-induced, in brain, bone marrow, and adrenal glands atIer intravenous administration (swine), 1034 natural killer cell, effect of cyclophosphamide, lead, and polychlorinated biphenyls in vivo and in vitro (rat), 158 D
Decahn subchronic inhalation toxicity study (dog, mouse, rat), 785 Developmental toxicity chemical embryotoxins in workplace: recognition, evaluation, and control, 626 diisopropylfluorophosphate subchronic intoxication effects on brain cholinergic systemsat prenatal and postnatal stages (rat), S204 environmentally-induced human reproductive hazards, risk assessment:historical overview, 609 mechanistic models, 634 risk assessment symposium introduction, 607 with teratology data, FDA perspectives (human), 6 15 symposium summarization, 653 Dexamethasone protective effectsin sulfur and nitrogen mustard-induced toxicity (rat), S 160 Diacetoxyscirpenol acute toxicopathic effectsatIer intravenous administration (swine), 1034 Diaminodiphenoxybutane -induced visual toxicity (conscious dog), 777 Diazepam with pyridostigmine, pretreatment: protective effect on soman and sarin poisoning (guinea pig), S225 Dibenz[u,c]anthracene reconstituted cytochrome P-450-induced mutagenic activation and inactivation (rat liver), 487 o-Dichlorobenzene inhalation exposure, teratogenicity evaluation (rabbit, rat), 190
1197
pDichlorobenzene inhalation exposure, teratogenicity evaluation (rabbit), 190 2,CDichlorophenol acute and subchronic oral toxicity (mouse), 478 N-(Dichlorophenyl)nimide isomeric, acute nephrotoxicity (Sprague-Dawley, Fischer 344 rats), 1119 2,3Dichloropropene disposition atIer inhalation exposure, effect of vapor concentration (Fischer-344 rat), 997 Diesel exhaust inhalation exposure effects on immune responses atIer lung immunization (mouse, rat), 1075 Diet L-buthionine-S,R-sulfoximine-induced long-term glutathione depletion, effect on lung, liver, kidney, and blood (mouse), 9 13 cellulose fiber and phytic acid manipulation, effect on blood lead concentration (monkey), 588 commercial alkyldimethylamine oxides, two-year chronic feeding study (rat), 869 dioxin-induced weight loss, hypophagia role (guinea pig, mouse, rat), 700 mirex and chlordecone combination, effect on carbon tetrachloride hepatotoxicity (rat), 679 styrene monomer-treated drinking water, chronic toxicity and three-generation reproduction study (rat), 855 Diethylene glycol monobutyl ether, see Butyl carbitol Diethylene glycol monomethyl ether, see Methyl carbitol Diisopropylaminoethyl-methylphosphonothiolate poisoning, molecular basis for prophylaxis and treatment: multiple actions of anticholinesterase agents on chemosensitive synapses (rat), S 182 Diisopropylfluorophosphate acetylcholinesterase recovery in murine central nervous system reaggregate cultures after acute exposure, 1104 neurotoxic effectson neurohypophysis atIer single and multiple exposures (cat), 1087 subchronic intoxication effects on brain chohnergic systemsat early developmental stages (rat), S204 toxicity, tolerance development: mechanisms (rat brain, liver, muscle), S 17 Dimethylamine inhalation toxicity after chronic exposure (mouse, rat), 341 Dimethylmercury and glutathione, biliary secretion and hepatic transport (rat), 816 -induced mitochondrial DNA synthesisin neural tissue (cat), 25 1 uptake by kidney, role of glutathione, 832 Dinitrotoluene teratologic evaluation (timed-pregnant Fischer 344 rat), 948
1198
SUBJECT INDEX
a-( l,4-Dioxido-3-methylquinoxalin-2-yl)-~-methylmtrone -induced adrenal cortex degeneration (dog, rat), 370 Dioxin induction of aryl hydrocarbon hydroxylase in vitro (rat hepatocytes), 7 13 weight loss, hypophagia role (guinea pig, mouse, rat), 700 -like activity, in vitro bioassay based on epithelial cell proliferation and morphology changes (murine teratoma), 754 Dipropylene glycol monomethyl ether metabolism and disposition (rat), 72 I Disopyramide phosphate effect on serum glucose and ghtcose counterregulation (dog), 539 DNA synthesis mitochondrial, methyl mercury-induced (feline brain), 251 Dosage maximum tolerated, in carcinogenicity testing, definition and evaluation, 66 E
Ear central, arterial blood pressure: direct measurement technique in canine toxicity, evaluation, 39 I Embryotoxins in workplace: recognition, evaluation, and control, 626 Epinephrine plasma concentrations, changes after T-2 toxin administration (swine), 879 Epoxide hydrolase hepatic microsomal, methapyrilene effect (rat), 165 Erythrocytes filterability, ozone effect: clinical test of 0s toxicity (vitamin E-deficient, -supplemented mice), I37 N-D-omithyl amphotericin B methyl ester-induced toxicity, subchronic studies (dog, rat), 737 Ethambutol -induced visual toxicity (conscious dog), 777 Ethanol teratogenicity evaluation after inhalation exposure (rat), 727 Ethanolamine distribution and metabolism after topical application (human skin grafts; murine, porcine skin), S127 2-Ethoxyethyl acetate hydrolysis by nasal mucosal carboxylesterase in vitro (dog, mouse, rabbit, rat), 399 Ethyl acrylate hydrolysis by nasal mucosal carboxylesteram in vitro (dog, mouse, rabbit, rat), 399 Ethylene inhalation exposure, chronic toxicity and oncogenicity bioassay (Fischer-344 rat), Vol. 4, p. 473; letter to editor, 203; reply, 204
Ethylene glycol monoethyl ether acetate, see f-Ethoxyethyl acetate Ethylene glycol monomethyl ether, see Methyl cellosolve Ethylene glycol monomethyl ether acetate, see Methyl cellosolve acetate Excretion I-nitropyrene, after oral or intrapetitoneal administration (rat), 287 Eye retina and ocular fundus, diaminodiphenoxybutane, quinine, and ethambutol-induced toxicity (conscious dog), 777 F
FDA, see Food and Drug Administration Fenvalerate neurophatmacologic and neuropathologic effects, (mouse, rat), 278 Fibrosis collagen synthesis at cellular level, 2 19 in fibrosing organs, chemical mediators, 228 development and assessment:symposium introduction, 207 -induced changes in collagen pathway (review), 2 10 pulmonary collagen content quantitation, 240 fluoride acute toxicity, renal, hepatic, and metabolic effects (sheep), 1025 Foci hepatic atlatoxin Br-induced enzyme-altered, selenium effect (rat), 320 assay,and strain A mouse lung tumor assay, carcinogenicity testing: comparison (rat), 688 spontaneously occurring, quantitation (rat), 3 14 Food and Drug Administration perspective on use of teratology data for human risk assessment,6 15 Fungi Amanita virosa, cyclic peptides: hepatotoxic effectsafter acute intoxication (mouse), I 144 G G-418 oral dosing, effect on skin and mucous membrane ulceration (beagle dog), 986 Genotoxicity P+t-hydroxyphenyl)retinamide, assessment, 144 Gentamicin -induced biphasic hindlimb paralysis, histological and electrophysiological assessment(rat), 933 Gentian violet carcinogenicity and chronic toxicity (B6C3Fl mouse), 902
SUBJECT INDEX GestatiOll
dinitrotoluene administration, teratologic evaluation (Fischer 344 rat), 948 hexachlorobenzene placental transfer, and lactational transfer: comparative effectson maternal and neonate tissue levels (mouse), 265 Glutathione and glutathione-metal complexes, bihaty secretion and hepatic transport (rat), 8 16 lon@erm depletion, after Lbuthionine-S,R-sulfoximine administration, effect on lung, liver, kidney, and blood (mouse), 9 13 role in hepatotoxicity of organic and metallic compounds (rat), 806 mercury uptake by kidney, 832 toxicology of metals: symposium introduction, 805 H
Heart output, and blood pressure changes at&r T-2 toxin administration (swine), 879 metallothionein concentration, effectsof various metals (la), 473 Heparin protective effectsin sulfur and nitrogen mustard-induced toxicity (rat), s 160 Hepatocytes aryl hydrocarbon hydroxylase induction by chlorinated aromatic hydrocarbons in vifro (rat), 7 13 2,4,5,2’,4’,5’-Hexabromobiphenyl photolysis characterization, 546 products hepatotoxicity and microsomal enzyme induction (rat), 555 Hexachlorobenzene maternal and neonate tissue levels after placental or lactational transfer, comparison (mouse), 265 HI-6, see l-(2-Hydroxyiminomethylpyridinium~2-(4carboxyamid~pytidium)dimethyl ether dichloride Hindlimb paralysis, biphasic, gentamicin-induced: histological and electrophysiological assessment (tat), 933 HJ6 pretreatment, protective effect on satin- and soman-induced inhalation toxicity (rat), S84 Horseradish peroxidase respiratory tract absorption and plasma clearance kinetics (guinea pig), 99 Hydrazine long-term inhalation toxicity studies (dog, hamster, mouse, rat), 1050 Hydrogen chloride inhalation toxicity, evaluation by carbon dioxide challenges (guinea pig), 978 l-(2-Hydroxyiminomethylpyridinium)-2-(4-carboxyamido-pyridium)dimethy1 ether dichloride
1199
blood levels, urinary excretion, and tolerance after intramuscular administration (human), 89 N-(4-Hydroxyphenyl)mtinamide genotoxicity assessment, 144 1-[2-Hydroxy-3-propyl-4-[4-( lH-tetrazol-5-yl)-butoxy]phenyllethanone, see Compound LY 17 1883 Hydroxyurea and 5-bromodeoxyuridine, teratogenic interaction: examination by limb culture and image analysis (mouse), 1161 teratologic evaluation (timed-pregnant Fischer 344 rat), 948 Hypoglycemia disopyramide phosphate-induced, and glucose counterregulation (dog), 539 Hypophagia role in dioxin-induced weight loss (guinea pig, mouse, rat), 700 I Immune responses antibody synthesis and interleukin 2 activity, effect of cyclophosphamide, lead, and polychlorinated biphenyls in vivo and in vitro (rat), 158 aBer lung immunization, diesel exhaust inhalation exposure effects (mouse, rat), 1075 Indecainide hydrochloride acute toxicity and 3-month subchronic toxicity studies (dog, monkey, mouse, rat), 175 Inhalation toxicity ammonia- or ozone-induced, effects on behavior (mouse, rat), 1110 asbestos, short fibers, after chronic exposure (monkey, rat), 327 bronchordveolar lavage Iluid analysis, pulmonary toxicity evaluation, 45 1 decalin a&r subchronic exposure (dog, mouse, rat), 785 2,3dichloropropene, vapor concentration effect on disposition (Fischer-344 rat), 997 diesel exhaust particles, chronic effects on immune responsesafter lung immunization (mouse, rat), 1075 dimethylamine after chronic exposure (mouse, rat), 34 1 bronchoalveolar lavage fluid analysis, evaluation, 45 1 hydrazine, long-term exposure effects (dog, hamster, mouse, rat), 1050 hydrogen chloride, evaluation by carbon dioxide challenges (guinea pig), 978 methanol and ethanol, teratogenicity evaluation (rat), 727 methyl carbitol, 13-week study (rat), 1174 monochlorodiisobutylene after acute and short-term exposure (mouse, rat), 506 mpiratoly tract clearance, mechanisms and measurement techniques (review), 435 morphological evaluation (review), 405
1200
SUBJECT INDEX
satin and soman, protective effectof oxime pretreatment (rat), s&l toluene, effects on carbon dioxide production and locomotor activity (mouse), 971 Intestines blood flow, radiation-induced increase: antihistamine effect (dog), 597 metallothionein concentration, effectsof various metals (rat), 473 transport, methotrexate effects (rat), 991 Iodide absorption and distribution after dietary exposure, chlorine dioxide effect (rat), 672 Iron effect on metallothionein concentration in major organs (rat), 473 K
6-Keto-prostaglandin F,, plasma concentrations, changes after T-2 toxin administration (swine), 879 Kidney cephaloridine toxicity: strain and sex differences (mouse), I 153 chlorodibromomethane toxicity and carcinogenic&y (B6C3Fl mouse, Fischer 344 rat), 1128 chloroform-induced carcinogenicity (Osborne-Mendel rat), 760 chronic toxicity of styrene monomer administration in drinking water (rat weanling), 855 function, effect of acute sodium fluoride poisoning (sheep), 1025 isomeric iV-@ichlorophenyl)nimide acute toxicity (Sprague-Dawley, Fischer 344 rats), 1119 long-term glutathione depletion effectsafter Lbuthionine-S,R-sulfoximine administration (mouse), 9 13 mercury uptake, role of glutathione, 832 metallothionein concentration, effectsof various metals (rat), 473 N-wrnithyl amphotericin B methyl ester-induced toxicity, subchronic studies (dog, rat), 737 stirofos oncogenicity evaluation (B6C3Fl mouse), 840 L
Lactation hexachlorobenzene exposure, and placental transfer: comparative eflhcts on maternal and neonate tissue levels (mouse), 265 Lead blood levels, diet effect (monkey), 588 effect on antibody synth~ interleukin 2 activity, and natural killer cell cytotoxicity in vivo and in vitro (rat), 158 metallotbionein concentration in major organs (rat), 473
Lethal dose (LD50) values upanddown procedure, development and statistical evaluation, 15 I Liver aflatoxin Bi-induced enzyme-altered foci, selenium effect (rat), 320 bromobenzene-induced toxicity, zinc protective effect, mechanism of action (rat), 297 carbon tetrachloride-induced toxicity, mirex and chlordecone effects after dietary exposure (rat), 679 chlorodibromomethane toxicity and carcinogenicity (B6C3Fl mouse, Fischer 344 rat), 1128 chloroform-induced carcinogenicity (B6C3Fl mouse), 760 chronic toxicity of styrene monomer administration in drinking water (rat weanling), 855 cytochrome P-450, interaction with trichloroethane isomers in vitro (rat), 353 diisopropylfhtorophosphate toxicity, tolerance development: mechanisms (rat), S I7 enlargement, compound LY 17 1883-induced, charao terization (hamster, mouse, rat), 794 fibrosis-induced changes in collagen pathway, review, 210 foci assay,and strain A mouse lung tumor assay, carcinogenicity testing: comparison (rat), 688 function, effect of acute sodium fluoride poisoning (sheep), 1025 glutathione metabolism and transport of metals to bile, analysis (rat), 8 16 hepatocytes, see Hepatocytes 2,4,5,2’,4’,5’-hexabromobiphenyl photolysis productinduced toxicity and microsomal enzyme response (rat), 555 long-term glutathione depletion effectsafter Lbuthionine-S,R-sulfoximine administration (mouse), 9 13 metallothionein concentration, effectsof various metals (rat), 473 monochlorobenzene-induced toxicity, dose-response and temporal characteristics (rat), 105 morphology and xenobiotic-metabolizing enzymes, methapyrilene effects (rat), 165 N-D-ornithyl amphotericin B methyl ester-induced toxicity, subchronic studies (dog, rat), 737 phalloidin and virotoxin effectsafter acute intoxication (mouse), 1144 reconstituted cytochrome P-450-induced mutagenic activation and inactivation ofcarcinogens (rat), 487 spontaneously occurring foci of cellular alteration, quantitation (rat), 3 14 stirofos oncogenicity evaluation (B6C3Fl mouse), 840 toxicity of organic and metallic compounds, role of glutathione (rat), 806 Lung, see also Respiratory tract bronchoalveolar lavage fluid, analysis for pulmonary toxicity evaluation, 45 1 diesel exhaust inhalation exposure effects on immune responses after immunization (mouse, rat), 1075
SUBJECT INDEX
changes in collagen pathway, review, 210 collagen synthesis, quantitation, 240 function in rodents, measurement techniques, 423 hydrogen chloride inhalation toxicity, evaluation by carbon dioxide challenges (guinea pig), 978 long-term ghttathione depletion effectsafter Lbuthionine-S,R-sulfoximine administration (mouse), 9 I3 metallothionein concentration, effectsof various metals (rat), 473 triethyl and trimethyl phosphorothioate toxicity (rat), S47 tumor assay,and rat hepatic foci assay:carcinogenicity testing: comparison (strain A mouse), 688 Lymph nodes pulmonary, diesel exhaust inhalation exposure effects after immunization (mouse, rat), 1075 M
Manganese effecton metallothionein concentration in major organs (rat), 473 Mecamylamine with atropine or physostigmine, pretreatment effect on sarin and VX poisoning (rat), S 182 Meclofenamate sodium effect on fertility and teratogenic evaluation (rat), 665 Membranes mucous, ulceration after G-4 I8 oral dosing (beagle dog), 986 Mepyramine effecton radiation-induced intestinal blood tlow increase (dog), 597 Mercury effecton metallothionein concentration in major organs (rat), 473 inorganic, and ghttathione, bii secretion and hepatic transport (rat), 8 I6 uptake by kidney, role of ghnathione, 832 Metabolism caffeine, after chronic consumption (female monkey), 578 carbon dioxide production as index (mouse), 962 and disposition dipropylene glycol monomethyl ether (rat), 72 I I-nitropyrene, after oral or intraperitoneal administration (rat), 287 effect of acute sodium tluoride poisoning (sheep), 1025 ethanolamine, at&r topical application (human skin grafts; murine, porcine skin), S127 Metallothionein concentration in major organs, effectsof various metals (rat), 473 Metals toxicity, uptake, and elimination, role of ghrtathione: symposium introduction, 805
1201
Methanol teratogenicity evaluation after inhalation exposure (rat), 727 Metbapyrilene effect on hepatic epoxide hydrolase and cytochrome P450dependent mixed-function oxidases, liver morphology, and liver-derived serum enzymes (rat), 165 Methotrexate effects on intestinal transit (rat), 99 I Methyl acrylate hydrolysis by nasal mucosal carboxylesterase in vitro (dog, mouse, rabbit, rat), 399 Methyl carbitol inhalation toxicity, 13-week study (rat), 1174 Methyl cellosolve effect on mating performance, epididymal spermatids, and spermatogonia (rat), 182 testicular recovery after short-term dosing: histology, cell-specific enzymes, and rete testis fluid protein (rat), 5 15 Methyl cellosolve acetate hydrolysis by nasal mucosal carboxylesterase in vitro (dog, mouse, rabbit, rat), 399 Methyl chloride effect on reproduction after inhalation exposure, twogeneration study (rat), 568 neurotoxicity, effect of continuous or intermittent exposure (C57BL/6 mouse), 87 pharmacokinetics after inhalation exposure (human), 361 Methyl mercury, see Dimethylmercury Methylpyridines, see Picolines Mirex and chlordecone combination, effect on carbon tetrachloride hepatotoxicity after dietaty exposure (rat), 679 Mixed-function oxidases, see Oxidases Models animal, see Animal models mechanistic, developmental toxicity risk assessment,634 skin development of rat/human sandwich flap served by defined and accessible vasculature on athymic rat, s112 toxicity testing, development, S98 Monochlorobenxene, see Chlorobenxene Monochlorodiisobutylene inhalation toxicity after acute and short-term exposure (mouse, rat), 506 Monosodium cyanurate mutagenicity evaluation in vitro and in vivo (Chinese hamster cells, murine lymphoma cells, rat), 655 Muscles diaphragm, extensor digitorum longus, and soleus: acute and subchronic pyridostigmine bromide exposure effects(rat), S260
1202
SUBJECT INDEX
skeletal, diisopropyltluorophosphate toxicity, tolerance development: mechanisms (rat), Si 7 Mustard gas -induced w&cation, molecular basis (human skin), S 134 sulfur and nitrogen, toxicity: protective effectsof dexamethasone, promethazine, vitamin E, heparin, and sodium thiosulfate (rat), S 160 Mutagenicity bmminated and chlorinated acetonitriles formed during chlorination of drinking water, 1065 monosodium cyanurate, evaluation in vitro and in vivo (Chinese hamster cells, murine lymphoma cells, rat), 655 N
National Cancer Institute carcinogenesis testing program: history, survival, and growth patterns of B6C3Fl mice and F344 rata, 526; erralum, 1188 Nerve agents patbology: perspectives on medical management, SlO Nemotoxicity diisopropylfluorophosphate and soman in neurohypophysis after single and multiple exposures (cat), 1087 fenvalerate-induced peripheral nerve fiber damage, and pharmacologic effect (mouse, rat), 278 gentamicin, induction of biphasic hindlimb paralysis: histological and electrophysiological assessment (rat), 933 methyl chloride, effect of continuous or intermittent exposure (C57BL/6 mouse), 87 pyridostigmine bromide acute and subchronic exposure in diaphragm, extensor digitorum longus, and soleus muscles (rat), S260 soman in brain and spinal cord (hen), S 180 Neurotoxicology acute exposure to (Y-,@-.and y-picoline (rat), 920 kindling and kindled seizures, drug and chemical effects, 41 neurophysiological techniques for evaluation of pyrethroid mechanism of action, in vifro and in vivo correlations, 9 toxic effectsand mechanisms of action at single neuronal systemic level, symposium introduction, 1 sensory evoked potentials, use in toxicity screening and determination of affected neural system, 24 Nickel effecton metallotbionein concentration in major organs (rat), 473 Z-Nitrofluorene reconstituted cytochrome P-450-induced mutagenic activation and inactivation (rat liver), 487 I-Nitropymne excretion and metabolism after oral or intraperitoneal administration (rat), 287
Norepinephrine plasma concentrations, changes after T-2 toxin administration (swine), 879 Nose mucosal tissue carboxylesterase, hydrolysis of glycol ether acetates and acrylate esters (dog, mouse, rabbit, rat), 399 olfactory sensory cells, effect of chronic dimethylamine inhalation exposure (mouse, rat), 341 0 Obidoxime chloride pretreatment, protective effect on satin- and soman-induced inhalation toxicity (rat), S84 Oncogenicity stirofbs in liver and kidney, evaluation (B6C3Fl mouse), 840 N-DOmithyl amphotericin B methyl ester subchronic toxicity studies (dog, rat), 737 Orthodichlorobenzene, see o-Dichlorobenzene Oxidases mixed-function, cytochrome H50dependent, methapyrilene effect (rat liver), 165 Oximes pretreatment, protective effect on satin- and soman-induced inhalation toxicity (rat), S84 Ozone effect on erythrocyte filterability as test of 0s toxicity (vitamin E-deficient, -supplemented mice), 137 -induced behavioral changes after inhalation exposure (mouse, rat), 1110 P Pancreas metallothionein concentration, effectsof various metals (rat), 473 Paradichlorobenzene, see pDichlorobenzene Paralysis biphasic hindlimb, gentamicin-induced: histological and electrophysiological assessment (rat), 933 Paraoxon tolerance, assessmentof behaviorally augmented component: role of reinforcement and response factors (la), s2 13 Petroleum hydrocarbons complex mixtures, Salmonella/microsome mutagenesis assayand murine dermal caminogenesis bioassay, comparison, 382 Phalloidin hepatotoxicity after acute intoxication (mouse), 1144 Pharmaceuticals from England, chronic animal toxicology studies, retrospective analysis, 1007 Pharmacokinetics 2,3dichloropropene after inhalation exposure, vapor concentration effect (Fischer-344 rat), 997
1203
SUBJECT INDEX ethanolamine after topical application (human skin grafts; murine, porcine skin), S127 HI-6 after intramuscular administration (human), S89 methyl chloride atIer inhalation exposure (human), 361 soman stereoisomers (mutine blood, tissues), S252 triethyl and trimethyl phosphorothioates (rat), S47 Physostigmine pretreatment effect on satin and VX poisoning (rat), S182 Picolines a-, /3-, and y-, acute exposure, neurophysiological consequences (rat), 920 Pituitary gland neurohypophysis, diisopropylfluorophosphate and soman neurotoxic effects after single and multiple exposures (cat), 1087 Plasma acid-base parameters, changes after T-2 toxin administration (swine), 879 ACTH levels after soman poisoning (mouse), S6 1 catecholamines, 6-keto-prostaglandin F,,, and thromboxane Br levels, T-2 toxin-induced changes (swine), 879 horseradish peroxidase clearance kinetics (guinea pig), 99 soman in vitro detoxification (human), S175 Pralidoxime chloride and atropine and soman interactions, application of response-surfacemodeling for evaluation (guinea pig), S232 Pralidoxime mesylate with pyridostigmine, pretreatment: protective effect on soman and satin poisoning (guinea pig), S225 Promethazine protective effectsin sulfiir and nitrogen mustard-induced toxicity (rat), Sl60 Propylene glycol monomethyl ether acetate hydrolysis by nasal mucosal carboxylesterase in vitro (dog, mouse, rabbit, rat), 399 Pyrethroids, see also specijic pyrethroids mechanism of action, in vitro and in vivo correlations, neurophysiological evaluation, 9 Pyridostigmine with atropine, pralidoxime mesylate, and diaxepam, pretreatment: protective effect on soman and satin poisoning (guinea pig), S225 Pyridostigmine bromide acute and subchronic exposure: neuromuscular toxicity in diaphragm, extensor digitorum longus, and soleus muscles (rat), S260 pretreatment effectson soman intoxication, evaluation by response-surface modeling (guinea pig), S242 Q Quinine -induced visual toxicity (conscious dog), 777
R Radiation -induced intestinal blood flow increase, antihistamine effect (dog), 597 Reproduction egg maturation and spawning, effect on 2,5,2’,5’-tetrachlorobiphenyl distribution and elimination (female yellow perch), 770 mating performance and epididymal spermatids and spermatogonia: ethylene glycol monomethyl ether effects (rat), 182 after styrene monomer administration in drinking water, three-generation study (rat), 855 Reproductive toxicity butyl carbitol, evaluation (rabbit, rat), 1137 meclofenamate sodium (rat), 665 methyl chloride alter inhalation exposure, two-generation study (rat), 568 potential indicators: testicular sperm production and epididymal sperm number, transit time, and motility (male Fischer 344 rats), 1097 Respiratory tract, see also Lung clearance mechanisms and measurement techniques (review), 435 horseradish peroxidase absorption kinetics (guinea pig), 99 immediate- and delayed-onset pulmonary hypcrsensitivity, animal models: immunotoxicologic evaluation, 459 structural evaluation for inhalation toxicity studies (review), 405 Response-surface modeling evaluation of pyridostigmine bromide pmtmatment effects in soman intoxication (guinea pig), S242 soman, atropine, and pralidioxime chloride interao tions (guinea pig), S232 Risk assessment carcinogens, extrapolation from mouse and rat bioassays,evaluation of interspecies correlation studies of carcinogenic potency, 79 chemical embryotoxins in workplace: recognition, evaluation, and control, 626 developmental toxicity mechanistic models, 634 symposium introduction, 607 environmentally-induced human reproductive hazards: historical overview, 609 G-4 18, effecton skin and mucous membrane ulceration: acute oral toxicity study (beagle dog), 986 gentian violet, evaluation in liver, linear extrapolation to virtually sate dose (B6C3Fl mouse), 902 pharmaceutical compounds from England, chronic animal toxicology studies: retrospective analysis, 1007 teratogenic hazards, symposium summarization, 653 use of teratology data, FDA perspectives (human), 6 I5
1204
SUBJECT INDEX S
Satin acute toxicity, behavioral analysis (marmoset), S169 inhalation toxicity, protective effect of oxime pretreatment (rat), S84 poisoning molecular basis for prophylaxis and treatment: multiple actions of anticholinesterase agents on chemosensitive synapses (rat), S 182 protective effect of pyridostigmine pretreatment with atropine, pralidoxime mesylate, and diazepam (guinea pig), S225 seizure pathology: perspectiveson medical management, SIO S&W3
kindled, drug and chemical effects,4 1 satin- and soman-induced, pathology: perspectives on medical management, SlO Selenium effect on emergence of aflatoxin Br-induced enzymealtered hepatic foci (rat), 320 Serum corticosterone, thyroxine, triiodothyronine, and testosterone levels after soman poisoning (mouse), S6 1 enzymes and biochemistry, effect of intravascular T-2 toxin (female swine), 893 Sex differences cephaloridine nephrotoxicity (mouse), 1153 Skin commercial alkyldimethylamine oxide administration, two-year chronic study (mouse), 869 flap, rat/human, served by defined and accessible vasculature on athymic rat, development, S I 12 models for toxicity testing, development, S98 mustard gas-induced vesication, molecular basis (human), S 134 toxicity testing, model development, S98 ulceration after G-4 18 oral dosing (beagle dog), 986 Sodium thiosulfate protective effectsin suhiu and nitrogen mustard-induced toxicity (rat), S 160 Soman and atropine and prahdioxime interactions, application of response-surfacemodeling for evaluation (guinea pig), S232 and BM 123, synergistic effects(rat), S78 dermatotoxicity, model development, S98 detoxification, role of carboxylesterases (rat), S29 inhalation toxicity, protective effect of oxime pretreatment (rat), S84 intoxication pyridostigmine bromide pretreatment effects: evaluation by response-surface modeling (guinea pig), S242 role of brain capillaries as blood-brain barrier (rabbit), s122
neurotoxic effectsin brain and spinal cord (hen), S180 neurohypophysis after single and multiple exposures (cat), 1087 in plasma, in vitro detoxification (human), S175 poisoning hormonal consequences (mouse), S61 protective effect of pyridostigmine pretreatment with atropine, prahdoxime mesylate, and diazepam (guinea pig), S225 seizure pathology: perspectiveson medical management, SlO stereoisomers, distribution and elimination and effect on brain acetylcholine (murine blood, tissues),S252 Spinal cord gentamicin-induced paralysis in biphasic hindlimb: histological and electrophysiological assessment(rat), 933 neuropathic effect of soman (hen), S180 Spleen metahothionein concentration, effectsof various metals (rat), 473 Stirofos oncogenic evaluation (B6C3Fl mouse), 840 Stomach iodide absorption and distribution, chlorine dioxide effect (rat), 672 metallothionein concentration, effectsof various metals (la), 473 Strain differences cephaloridine nephrotoxicity (mouse), 1153 Styrene monomer -treated drinking water, chronic toxicity and three-generation reproduction study (rat), 855 Synergism between soman and N4(2-Chloroethylamino~2-butynyl-2-pyrollidine (rat), S78 T
TCDD, see Dioxin Teratogenicity butyl carbitol, evaluation (rabbit, rat), I 137 data for human risk assessment: FDA perspectives on use, 615 dichlorobenzenes alter inhalation exposure (rabbit, rat), 190 environmental chemicals, risk assessment, historical overview (human), 609 ethanol and methanol, evaluation after inhalation exposure (rat), 727 hydroxyurea administration in timed-pregnant Fischer 344 rats, 948 interaction of hydroxyurea and 5-bromodeoxyuridine, examination by limb culture and image analysis (mouse), I161
SUBJECT INDEX
1205
meclofenamate sodium, evaluation (rat), 665 chronic feeding and dermal studies (mouse, rat), 869 Testes pulmonary hmction in rodents, measurement techmetallothionein concentration, effectsof various metals niques, 423 (rat), 413 skin models, development, S98 recovery after short-term ethylene glycol monomethyl ether dosing: histology, cell-specific enzymes, and Toxogonin, see Obidoxime chloride rete testis 5uid protein (rat), 5 15 1,1,l -Trichloroethane sperm production and epididymal sperm number, interaction with cytochrome P-450 (perfused rat liver), transit time, and motility: potential indicators of 353 reproductive toxicity (Fischer 344 rats), 1097 1,1,2-Trichloroethane Testosterone interaction with cytochrome P-450(perfused rat liver), serum levels after soman poisoning (mouse), S6 1 353 2,5,2’,5’-Tetrachlorobiphenyl Trichothecenes distribution and elimination after chronic exposure, detoxification, role of carboxylesterases (rat), S29 spawning effect (female yellow perch), 770 Triethyl phosphorothioates 2,3,7,8-Tetrachlorodibenzo-p-dioxin, see Dioxin phannacokinetics and pulmonary toxicity (rat), S47 Tetrachloninphos, see Stirofos Triiodothyronine Thromboxane Bs serum levels after soman poisoning (mouse), S6 1 plasma concentrations, changes after T-2 toxin adminTrimethyl phosphorothioates istration (swine), 879 pharmacokinetics and pulmonary toxicity (rat), S47 Thyroxine T-2 toxin serum levels after soman poisoning (mouse), S6 1 intravascular administration, effect on Tolerance cardiac output, blood pressure, catecholamines, 6diisofluorophosphate, toxicity, development: mechaketo-prostagIandin F,,, thromboxane Br,, and acidnisms (rat brain, liver, muscle), S 17 base parameters (swine), 879 HI-6, after intramuscular administration (human), S89 serum enzymes and biochemistry, blood coagulation, paraoxon, assessmentof behaviorally augmented comand hematology (female swine), 893 ponent: role of reinforcement and response factors (rat), S2 13 Toluene U inhalation effectson carbon dioxide production and locomotor activity (mouse), 97 1 Urine Toxicity HI-6 excretion after intramuscular administration (huacute, oral: G-4 18 effectson skin and mucous membrane man), S89 ulceration (beagle dog), 986 chronic, gentian violet (B6C3Fl mouse), 902 metals, role of glutathione: symposium introduction, V 805 organophosphorus anticholinesterases and trichotheVesication cenes, role of carboxylesterases in detoxification mustard gas-induced, molecular basis (human skin), (rat), S29 s134 sarin and soman, protective effect of pyridostigmine Virotoxins pretreatment with atropine, pralidoxime mesylate, hepatotoxicity after acute intoxication (mouse), 1144 and diazepam (guinea pig), S225 Vitamin E sulfur and nitrogen mustard-induced, protective effects protective effectsin sulfur and nitrogen mustard-induced of dexamethasone, promethazine, vitamin E, heg toxicity (rat), S 160 arm, and sodium thiosulfate (rat), S160 VX, see Diisopropylamineothyl-methylphosphonothiolate Toxicity testing baseline clinical pathology parameters, variations: effect of blood sampling site and collection method (Fischer 344 rat), 1180 Zinc canine, direct blood pressure measurement, evaluation, effect on metallothionein concentration in major organs 391 chronic animal, pharmaceuticals from England, retro(rat), 473 spective analysis, 1007 protective effecton bromobenzene hepatotoxicity (rat), 297 commercial alkyldimethylamine oxides, two-year