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Technique of organic chemistry. Vol. 111. Part 11: Laboratory engineering. Edited by Arnold Weissberger. Interscience Publishers, Inc., New York, 1957. ix f 391 pp. 16 × 23 cm. Price $8
June 1957
SCIENTIFIC EDITION
ture was stirred constantly during addition. i\ yellow precipitate formed almost immediately. This mixture was allowed to stand for 30 minutes and then the product was removed by filtration and washed with cold water. Thus, 4.5 Gm. (83%) of the desired product was obtained. The product thus obtained was recrystallized from ethanol, m. p. 165-166”. Anal.-Calcd. for CleHI;ItNOC: C. 34.62; H, 2.72. Found: C. 34.67; H, 2.37. 3,5 - Diiodo 4 (4’ - hydroxyphenoxy) - betapheny1serine.-One-half gram of 3,5-diiodo-4-(4’methoxyphenoxy) phenylserine was dissolved in 5 ml. of glacial acetic acid and refluxed for one hour with 5 ml. of hydriodic acid, sp. gr. 1.7. The reaction mixture was then poured into 25 ml. of dis-
-
-
389
tilled water and allowed to cool. The resulting solid [O.4Gm. (SO%)] was recrystallized from ethanol to a constant melting point of 160”. Anal.-Calcd. for C1SH1J2N05: C, 33.29; H, 2.40. Found: C, 33.41; H, 2.44.
REFERENCES (1) Harington, C.R.,and Earger, G., Biochem. J . , London 21, 169(1927). 2 (2) Selenkow, H. A., and Asper, S. P., Physiol. R e m , 35, 426(1955). (3) Woolley, D. W . , J . B i d . Chem., 164, l l ( l 9 4 6 ) . (4) (4) Woolley, D.W . , Science, 100,570(1944). ( 5 ) Woolley, D.W . , “A Study of Antimetabolites,” John Wiley and Sons, Inc., New Yorr, 1952, pp. P P . 64--5.5. (6f op. cit., p . 222. and Redemann, C. E., J . A m . Chem. Sor., (7) Niemann, C., 63,154WI941). ( 8 ) Erlenmeyer, E., and Fruestueck, C . , Aniz., 284, 36 (1899). ~~
Book Notices Accidental Poisoning in Childhood. By EDWARD PRESS. Prepared by The Committee on -1ccident Prevention, American Academy of Pediatrics, Charles C Thomas, Springfield, Illinois, 1955. xiv f 131 pp. 14 x 22 cm. This is a very useful reference-guide to the chemical constituents of common household substances, together with recommended treatment, by first aid and by the physician, following their accidental ingestion by children. The preliminary edition of this book has been used in Poison Control Centers and by hospitals and physicians, and it has been revised to incorporate many suggestions. I t is divided into 3 sections with different colored pages covering: I. treatment procedures; 11. list of toxic substances aud suggested treatment; 111. toxic constituents of household products. The book should be in the hands of all pharmacists and physicians, particularly for its listing of the toxic ingredients of many products that do not give this important information on the label. Year Book of Drug Therapy (1956-1957 Series ) Edited by HARRYBECKMAN.The Year Book Publishers, Inc., Chicago, 1957. 514 pp. 13 x 20 cni. Price $6.75. This issue of the Year Book continues to reflect Dr. Beckman’s excellent coverage of important developments in the field of drug therapy by means of concise, yet thoroughly informative abstracts of reports that were published in journals received between August, 1955 and August, 1956. The editor’s usually interesting commentary in the Introduction deals with the current views regarding serotonin (5-hydroxytryptamine) and lysergic acid diethylamide (LSD), the two compounds that have been studied extensively in attempts to elucidate some biochemical relationship for the action of tranquilizing drugs. He concludes the picture is
still nebulous. The book is a must for the ready reference library, and its m e is facilitated with a good subject index and an author index. Technique of Organic Chemistry. Vol. 111. Part 11: Laboratory Engineering. Edited by ARNOLD WEISSBERGER.Interscience Publishers, Inc., New York, 1957. ix f 391 pp. 16 x 23 cm. Price $8. This second part of volume 111 includes dis cussions of the following subjects: selection of materials for the construction of equipment, heating and cooling, grinding, screening, classifying, mixing, and operations with gases. This more selective and specialized part complements the first part of volume 111 which was reviewed in THISJOURNAL,46, 329(1957). Information that is useful in laboratory development and utilization is included. The thorough documentation extends to the items included in a tabulation of liquids used for heating baths. Appended are an index and a cumulative index for volumes I through I X giving the authors and their s u b j c t s and a listing by subjects. Pharmacists, particularly those in manfacturing, will find the chapters on grinding, screening, classifying, and mixing of practical interest. Pharmacognosy Laboratory Manual. By MAYNARD W. QUIMBY,RAYMOND W. VANDERWYK, and JR. Massachusetts College WILLIAME . HASSAN, of Pharmacy, Boston, 1957. viii f 110 pp. 22 x 22.5 cm. Price $3. The manual is planned to acquaint the student with the techniques required for the study of plants, and divides the laboratory material into parts dealing with harmful plants and drugs and products of economic importance of biological origin. Books
SCIENTIFIC EDITION
ture was stirred constantly during addition. i\ yellow precipitate formed almost immediately. This mixture was allowed to stand for 30 minutes and then the product was removed by filtration and washed with cold water. Thus, 4.5 Gm. (83%) of the desired product was obtained. The product thus obtained was recrystallized from ethanol, m. p. 165-166”. Anal.-Calcd. for CleHI;ItNOC: C. 34.62; H, 2.72. Found: C. 34.67; H, 2.37. 3,5 - Diiodo 4 (4’ - hydroxyphenoxy) - betapheny1serine.-One-half gram of 3,5-diiodo-4-(4’methoxyphenoxy) phenylserine was dissolved in 5 ml. of glacial acetic acid and refluxed for one hour with 5 ml. of hydriodic acid, sp. gr. 1.7. The reaction mixture was then poured into 25 ml. of dis-
-
-
389
tilled water and allowed to cool. The resulting solid [O.4Gm. (SO%)] was recrystallized from ethanol to a constant melting point of 160”. Anal.-Calcd. for C1SH1J2N05: C, 33.29; H, 2.40. Found: C, 33.41; H, 2.44.
REFERENCES (1) Harington, C.R.,and Earger, G., Biochem. J . , London 21, 169(1927). 2 (2) Selenkow, H. A., and Asper, S. P., Physiol. R e m , 35, 426(1955). (3) Woolley, D. W . , J . B i d . Chem., 164, l l ( l 9 4 6 ) . (4) (4) Woolley, D.W . , Science, 100,570(1944). ( 5 ) Woolley, D.W . , “A Study of Antimetabolites,” John Wiley and Sons, Inc., New Yorr, 1952, pp. P P . 64--5.5. (6f op. cit., p . 222. and Redemann, C. E., J . A m . Chem. Sor., (7) Niemann, C., 63,154WI941). ( 8 ) Erlenmeyer, E., and Fruestueck, C . , Aniz., 284, 36 (1899). ~~
Book Notices Accidental Poisoning in Childhood. By EDWARD PRESS. Prepared by The Committee on -1ccident Prevention, American Academy of Pediatrics, Charles C Thomas, Springfield, Illinois, 1955. xiv f 131 pp. 14 x 22 cm. This is a very useful reference-guide to the chemical constituents of common household substances, together with recommended treatment, by first aid and by the physician, following their accidental ingestion by children. The preliminary edition of this book has been used in Poison Control Centers and by hospitals and physicians, and it has been revised to incorporate many suggestions. I t is divided into 3 sections with different colored pages covering: I. treatment procedures; 11. list of toxic substances aud suggested treatment; 111. toxic constituents of household products. The book should be in the hands of all pharmacists and physicians, particularly for its listing of the toxic ingredients of many products that do not give this important information on the label. Year Book of Drug Therapy (1956-1957 Series ) Edited by HARRYBECKMAN.The Year Book Publishers, Inc., Chicago, 1957. 514 pp. 13 x 20 cni. Price $6.75. This issue of the Year Book continues to reflect Dr. Beckman’s excellent coverage of important developments in the field of drug therapy by means of concise, yet thoroughly informative abstracts of reports that were published in journals received between August, 1955 and August, 1956. The editor’s usually interesting commentary in the Introduction deals with the current views regarding serotonin (5-hydroxytryptamine) and lysergic acid diethylamide (LSD), the two compounds that have been studied extensively in attempts to elucidate some biochemical relationship for the action of tranquilizing drugs. He concludes the picture is
still nebulous. The book is a must for the ready reference library, and its m e is facilitated with a good subject index and an author index. Technique of Organic Chemistry. Vol. 111. Part 11: Laboratory Engineering. Edited by ARNOLD WEISSBERGER.Interscience Publishers, Inc., New York, 1957. ix f 391 pp. 16 x 23 cm. Price $8. This second part of volume 111 includes dis cussions of the following subjects: selection of materials for the construction of equipment, heating and cooling, grinding, screening, classifying, mixing, and operations with gases. This more selective and specialized part complements the first part of volume 111 which was reviewed in THISJOURNAL,46, 329(1957). Information that is useful in laboratory development and utilization is included. The thorough documentation extends to the items included in a tabulation of liquids used for heating baths. Appended are an index and a cumulative index for volumes I through I X giving the authors and their s u b j c t s and a listing by subjects. Pharmacists, particularly those in manfacturing, will find the chapters on grinding, screening, classifying, and mixing of practical interest. Pharmacognosy Laboratory Manual. By MAYNARD W. QUIMBY,RAYMOND W. VANDERWYK, and JR. Massachusetts College WILLIAME . HASSAN, of Pharmacy, Boston, 1957. viii f 110 pp. 22 x 22.5 cm. Price $3. The manual is planned to acquaint the student with the techniques required for the study of plants, and divides the laboratory material into parts dealing with harmful plants and drugs and products of economic importance of biological origin. Books