- Email: [email protected]
Time trends in hospital admissions and mortality due to abdominal aortic aneurysms in France, 2002–2013
106
06-Arterial hypertension and vascular disease 2
Conclusion This study highlighted the importance of monitoring women for PE after a hospitalization for preeclampsia and women with chronic hypertension during pregnancy and postpartum. Disclosure of interest The authors declare that they have no competing interest.
CREATIS, université Claude-Bernard Lyon 1, Lyon Service d’hypertension artérielle, hôpital Européen Georges-Pompidou, Paris, France ∗ Corresponding author. E-mail address: [email protected] (P. Courand)
https://doi.org/10.1016/j.acvdsp.2017.11.213
Background The DENERHTN trial confirmed the daytime ambulatory systolic blood pressure (dASPB) lowering efficacy of renal denervation (RDN) added to a standardized stepped-care antihypertensive treatment (SSAHT) for resistant hypertension at 6 months. This post-hoc analysis assessed the impact of abdominal aortic calcifications (AAC) on the hemodynamic and renal response to RDN at 6 months. Methods A total of 106 patients with resistant hypertension were randomly assigned to RDN + SSAHT, or the same SSAHT alone (control group). Total AAC volume was measured from the aortic hiatus to the iliac bifurcation, blind to randomization, with semiautomatic software, on the pre-randomization non-contrast abdominal CT-scans of 90 patients and expressed as tertiles. Results The baseline-adjusted difference in the change in dASBP from baseline to 6 months between the RDN and control groups was −10.1 mmHg (P = 0.0462) in the lowest tertile of AAC volume and −2.5 mmHg (P = 0.4987) in the two highest tertiles of AAC volume. Estimated glomerular filtration rate (eGFR) remained stable at 6 months in the patients with the lowest tertile of AAC volume who underwent RDN (+2.5 mL/min/1.73 m2 ) but decreased in the control group (−8.0 mL/min/1.73 m2 , P= 0.0148). In the two highest tertiles of AAC volume, eGFR decreased similarly in the RDN and the control groups (P = 0.2640). Conclusion RDN plus SSAHT resulted in a larger decrease in dASBP than SSAHT alone in patients with a lower AAC burden than in those with a higher AAC burden. This larger decrease in dASBP was not associated with a decrease in eGFR. Disclosure of interest The authors declare that they have no competing interest.
463
Determinants of prescription of Direct Oral Anticoagulants (DOACs) in pulmonary embolism: A multidisciplinary multicentre prospective registry J. Andarelli 1,∗ , R. Chopard 1 , N. Meneveau 2 1 Chu Besanc ¸on, Besanc¸on 2 Cardiologie, CHU Besanc ¸on, Besancon, France ∗ Corresponding author. E-mail address: [email protected] (J. Andarelli) Background Direct oral anticoagulants (DOACs) have become for a few years an alternative to the use of vitamin K antagonists (VKA) as oral anticoagulant strategy to treat acute pulmonary embolism(PE). However, data in routine clinical practice are needed. Purpose We conducted a prospective multicentre multidisciplinary registry study to show baseline characteristics of patients treated with DOACs in acute PE, to identify factors that independently influence therapeutic decision to prescribe or not DOACs and to analyse factors of inappropriate prescription of DOACs. Methods We included all patients discharged with the objectively confirmed diagnosis of acute PE in 10 centres in Franche-Comté and Burgundy for 4 years. Participating centres were 5 cardiology departments but also Intensive Care Unit, Oncology, Orthopaedic surgery and Internal medicine departments. Results Between September 2012 and December 2016, 1157 patients were enrolled from 10 centres. Among discharged patients (n = 1113), 61.7% (n = 687) were treated with DOACs and 38.3% (n = 426) with another or no anticoagulant. Those who received DOACs had less comorbidities, a lower cardiac biomarkers and plasmatic creatinine level and a lower early mortality risk. Prescription frequency of DOACs increased from 2012 to 2016. An older age (OR = 0.76 (0.66—0.88), P < 0.001), a chronic kidney disease with creatinine clearance inferior to 30 mL/mn (OR 0.24 (0.11—0.42), P < 0.001), an active cancer (OR = 0.016 (0.008—0.03), P < 0.001) and an in-hospital bleeding (OR = 0.27 (0.12—0.59), P < 0.001) are strong predicting factors in favour of non-prescription of DOAC. A cardiological centre hospitalization is a predictor of the decision to prescribe DOACs (OR = 4.8 (3.3—6.8), P < 0.001). Conclusions Our registry shows that DOACS are already used regularly in daily clinical practice for acute PE treatment with a progressive increased rate of DOACs prescription with more than 60% of patients receiving DOACs in our registry. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2017.11.214 399
Abdominal aortic calcifications influence the systemic and renal hemodynamic response to renal denervation in the DENERHTN trial P. Courand 1,2,∗ , H. Pereira 3 , C. Del Giudice 3 , P. Lantelme 1,2 , M. Sapoval 3 , M. Azizi 3 1 Hospices civils de Lyon
3
https://doi.org/10.1016/j.acvdsp.2017.11.215 146
Time trends in hospital admissions and mortality due to abdominal aortic aneurysms in France, 2002—2013 A. Gabet 1 , M. Robert 1 , Y. Juilliere 2 , S. Kownator 3 , V. Olié 1,∗ 1 Santé publique France, Saint-Maurice 2 CHU Nancy, Vandoeuvre les Nancy 3 Centre de cardiologie, Thionville, France ∗ Corresponding author. E-mail address: [email protected] (V. Olié) Background Abdominal aortic aneurysms (AAA) are serious disease with a high fatality rate but recent epidemiologic data in France are lacking. Purpose Our objective was to estimate, in France, the hospitalization, in hospital mortality and mortality rates due to AAA and to analyze their trends over time. Methods Hospitalization data were extracted from the hospital discharge summaries in the national database between 2002 and 2013. The analysis covered all patients hospitalized for AAA as a principal diagnosis. During the same period, all death certificates mentioning AAA as an initial cause of death were included in the study. Crude and standardized rates were calculated according to age and sex. Poisson regression was used to analyze the average annual percent change. Results In 2013, there were 8 853 patients hospitalized for AAA in France (7 986 unruptured and 867 ruptured). Between 2002 and 2013, the rate of patients hospitalized for unruptured AAA decreased slightly in men (−5.0%) but increased in women (+5.2%). By contrast, the rate of patients hospitalized for ruptured AAA has decreased by more than 20% in men and women. The proportion
06-Arterial hypertension and vascular disease of endovascular treatment of unruptured AAA rose from less than 10% in 2005 to 35% in women and 40% in men in 2013. In 2013, 939 deaths from AAA were recorded. Mortality for this disease declined significantly from 2002 to 2013 in men and women. Conclusion The unfavorable epidemiological trends in women and important evolution of the management of AAA call for an epidemiological surveillance of this disease. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2017.11.216
January 19th, Friday 2018 470
Mitral valve phenotype in vascular Ehlers Danlos syndrome S. Zarka 1 , A. Rossi 2 , S. Abouth 2 , M. Frank 2 , G. Goudot 2 , X. Jeunemaitre 2 , T. Mirault 2 , E. Messas 1,∗ 1 Médecine vasculaire, hôpital Européen Georges-Pompidou 2 Médecine vasculaire, HEGP, Paris, France ∗ Corresponding author. E-mail address: [email protected] (E. Messas) Background Vascular Elhers-Danlos syndrome (vEDS) is a genetic vascular disease, affecting the production of the collagen type III, a component of the arterial wall, but also in the mitral valve (MV). Some small families studies suggest an association between vEDS and mitral valve prolapse [MVP] but a complete evaluation of MV phenotype on vEDS cohort was never performed. Purpose To describe the MV phenotype in a population of vEDS. Methods A total of 45 patients with vEDS, with characterized mutation of the COL3A1 gene, were included in a prospective singlecenter study and assessed by echocardiography. Results Among the 45 patients, no MVP was found. MV floppy was observed in 6 patients (13%) but the mean MV thickness of 2.7 ± 0.1 mm for all the group was not above normal (normal values [NV] < 3 mm). MV billowing was observed in 2 patients (4%).35 patients (78%) had mitral insufficiency but none were more than mild (trace 26 [58%] and mild 9 [20%]) and there was no mitral stenosis (mean mitral gradient = 1.31 ± 1 mmHg). Anterior leaflet length was 24 ± 0.5 mm (vs. NV = 22—23 mm), posterior leaflet length was 13.7 ± 0.3 mm (NV = 12—13 mm) and strut chordae length was 20.4 ± 1 mm (NV < 20 mm). Mitral annulus (MA) diameter was 33.1 ± 0.6 mm in the parasternal long axis view (PSLAV) (NV = 31.5 ± 0.5 mm) and 33.7 ± 0.6 mm in apical 4 chambers view (A4CV) (NV = 30.5 ± 0.4 mm) for men. In women, MA diameter was 30.4 ± 0.5 mm in PSLAV (NV = 28.3 ± 0.4 mm) and 29.5 ± 0.6 mm in A4CV (NV = 27.7 ± 0.3 mm). The ratio between MA diameter and the mitral anterior leaflet height was calculated at 1.3 ± 0.03 (NV < 1.3). Two case of ruptured mitral chordae with a previously normal echocardiographic MV were observed. Conclusion Through a single cohort of vEDS, there was no evidence of MVP despite cases of chordal ruptured. MA and mitral leaflets were larger than the classical published value. More studies are needed to better characterized the biomecanic of the MV apparatus explaining the rare occurrence of MV chordae rupture. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2017.11.217
107 328
Influence of the Sievers type and valvular functional impairment in bicuspid associated aortopathy in a prospective series G. Goudot 1,∗ , T. Mirault 2 , A. Rossi 2 , J. Albuisson 3 , S. Zarka 2 , J.M. Mazzella 3 , X. Jeunemaitre 3 , M. Pernot 1 , E. Messas 2 1 Inserm U979, institut Langevin 2 Médecine vasculaire, hôpital Européen Georges-Pompidou 3 PARCC Inserm U970, Paris, France ∗ Corresponding author. E-mail address: [email protected] (G. Goudot) Objective Bicuspid aortic valve (BAV) is associated with high incidence of ascending aortic aneurysm. In BAV sporadic form, changes in outflow’s hemodynamic secondary to the valvular morphotype are said to play a prominent role in the aortic dilatation. We aimed at comparing the different ascending aorta segment diameters according to the morphotype and the function of the BAV. Methods We evaluated 174 patients with sporadic BAV by transthoracic echocardiography. The valvular function was defined as either Aortic Insufficiency (AI) if Grade ≥ 2 and aortic Stenosis (AS) if mean gradient > 20 mmHg. Aortic diameters were measured at the Valsalva sinus, tubular ascending aorta and at the aortic arch. Kruskal-Wallis, Mann—Whitney and Spearman tests were used for comparisons. Results Among the non-operated patients, Sievers’ morphotype was type 1LR for 63%, type 1NR for 18%, and other types counted for 19%. The Valsalva sinus diameter did not differ according to the Sievers’ type (P = 0.78). The type 1LR type compared to the type1NR appeared to have a wider tubular aorta, but not significantly (42.3 ± 8.5 vs. 36.4 ± 7.3 mm; P = 0.06). Aortic valve function was distributed as follows: AI: 39%, AS: 20%, Both: 9%, Normal: 32%. Comparison of the different valve dysfunctions revealed a difference at the Valsalva (P < 10—4) and the tubular aorta (P = 0.001) but not at the aortic arch level (P = 0.62). AI was highly associated with an increase of the aortic diameters of any segment, excepting for the arch. In addition, aortic diameters increased with age in case of AI (Valsalva: r = 0.28; P = 0.02; Tubular aorta: r = 0.27; P = 0.02) and not in case of AS (r = —0.06; P = 0.73 and r = —0.03; P = 0.84). Conclusion Our results showed the tremendous role of AI in the aortic dilation of all segments except the arch. However no influence of BAV morphotype was noticed on aortic diameters. Our results give rise to the relatively limited influence of the valvular morphology in the development of aortic dilation. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2017.11.218 182
Biomarker and cardiovascular profiles of healthy aging, putting multiple biomarkers in perspective S. Bouajila 1,2,∗ , K.J. Moneghetti 1,2 , Y. Kobayashi 1,2 , F. Abbasi 2 , F.A. Gomari-Grisar 3 , T. Kuznetsova 1,4 , J.C. Wu 1,2 , F. Haddad 1,2 1 Stanford cardiovascular institute, Stanford, CA 2 Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States 3 Department of Internal Medicine II, Division of Cardiology and Angiology, Medical University of Vienna, Vienna, Austria 4 Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium ∗ Corresponding author. E-mail address: [email protected] (S. Bouajila)
06-Arterial hypertension and vascular disease 2
Conclusion This study highlighted the importance of monitoring women for PE after a hospitalization for preeclampsia and women with chronic hypertension during pregnancy and postpartum. Disclosure of interest The authors declare that they have no competing interest.
CREATIS, université Claude-Bernard Lyon 1, Lyon Service d’hypertension artérielle, hôpital Européen Georges-Pompidou, Paris, France ∗ Corresponding author. E-mail address: [email protected] (P. Courand)
https://doi.org/10.1016/j.acvdsp.2017.11.213
Background The DENERHTN trial confirmed the daytime ambulatory systolic blood pressure (dASPB) lowering efficacy of renal denervation (RDN) added to a standardized stepped-care antihypertensive treatment (SSAHT) for resistant hypertension at 6 months. This post-hoc analysis assessed the impact of abdominal aortic calcifications (AAC) on the hemodynamic and renal response to RDN at 6 months. Methods A total of 106 patients with resistant hypertension were randomly assigned to RDN + SSAHT, or the same SSAHT alone (control group). Total AAC volume was measured from the aortic hiatus to the iliac bifurcation, blind to randomization, with semiautomatic software, on the pre-randomization non-contrast abdominal CT-scans of 90 patients and expressed as tertiles. Results The baseline-adjusted difference in the change in dASBP from baseline to 6 months between the RDN and control groups was −10.1 mmHg (P = 0.0462) in the lowest tertile of AAC volume and −2.5 mmHg (P = 0.4987) in the two highest tertiles of AAC volume. Estimated glomerular filtration rate (eGFR) remained stable at 6 months in the patients with the lowest tertile of AAC volume who underwent RDN (+2.5 mL/min/1.73 m2 ) but decreased in the control group (−8.0 mL/min/1.73 m2 , P= 0.0148). In the two highest tertiles of AAC volume, eGFR decreased similarly in the RDN and the control groups (P = 0.2640). Conclusion RDN plus SSAHT resulted in a larger decrease in dASBP than SSAHT alone in patients with a lower AAC burden than in those with a higher AAC burden. This larger decrease in dASBP was not associated with a decrease in eGFR. Disclosure of interest The authors declare that they have no competing interest.
463
Determinants of prescription of Direct Oral Anticoagulants (DOACs) in pulmonary embolism: A multidisciplinary multicentre prospective registry J. Andarelli 1,∗ , R. Chopard 1 , N. Meneveau 2 1 Chu Besanc ¸on, Besanc¸on 2 Cardiologie, CHU Besanc ¸on, Besancon, France ∗ Corresponding author. E-mail address: [email protected] (J. Andarelli) Background Direct oral anticoagulants (DOACs) have become for a few years an alternative to the use of vitamin K antagonists (VKA) as oral anticoagulant strategy to treat acute pulmonary embolism(PE). However, data in routine clinical practice are needed. Purpose We conducted a prospective multicentre multidisciplinary registry study to show baseline characteristics of patients treated with DOACs in acute PE, to identify factors that independently influence therapeutic decision to prescribe or not DOACs and to analyse factors of inappropriate prescription of DOACs. Methods We included all patients discharged with the objectively confirmed diagnosis of acute PE in 10 centres in Franche-Comté and Burgundy for 4 years. Participating centres were 5 cardiology departments but also Intensive Care Unit, Oncology, Orthopaedic surgery and Internal medicine departments. Results Between September 2012 and December 2016, 1157 patients were enrolled from 10 centres. Among discharged patients (n = 1113), 61.7% (n = 687) were treated with DOACs and 38.3% (n = 426) with another or no anticoagulant. Those who received DOACs had less comorbidities, a lower cardiac biomarkers and plasmatic creatinine level and a lower early mortality risk. Prescription frequency of DOACs increased from 2012 to 2016. An older age (OR = 0.76 (0.66—0.88), P < 0.001), a chronic kidney disease with creatinine clearance inferior to 30 mL/mn (OR 0.24 (0.11—0.42), P < 0.001), an active cancer (OR = 0.016 (0.008—0.03), P < 0.001) and an in-hospital bleeding (OR = 0.27 (0.12—0.59), P < 0.001) are strong predicting factors in favour of non-prescription of DOAC. A cardiological centre hospitalization is a predictor of the decision to prescribe DOACs (OR = 4.8 (3.3—6.8), P < 0.001). Conclusions Our registry shows that DOACS are already used regularly in daily clinical practice for acute PE treatment with a progressive increased rate of DOACs prescription with more than 60% of patients receiving DOACs in our registry. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2017.11.214 399
Abdominal aortic calcifications influence the systemic and renal hemodynamic response to renal denervation in the DENERHTN trial P. Courand 1,2,∗ , H. Pereira 3 , C. Del Giudice 3 , P. Lantelme 1,2 , M. Sapoval 3 , M. Azizi 3 1 Hospices civils de Lyon
3
https://doi.org/10.1016/j.acvdsp.2017.11.215 146
Time trends in hospital admissions and mortality due to abdominal aortic aneurysms in France, 2002—2013 A. Gabet 1 , M. Robert 1 , Y. Juilliere 2 , S. Kownator 3 , V. Olié 1,∗ 1 Santé publique France, Saint-Maurice 2 CHU Nancy, Vandoeuvre les Nancy 3 Centre de cardiologie, Thionville, France ∗ Corresponding author. E-mail address: [email protected] (V. Olié) Background Abdominal aortic aneurysms (AAA) are serious disease with a high fatality rate but recent epidemiologic data in France are lacking. Purpose Our objective was to estimate, in France, the hospitalization, in hospital mortality and mortality rates due to AAA and to analyze their trends over time. Methods Hospitalization data were extracted from the hospital discharge summaries in the national database between 2002 and 2013. The analysis covered all patients hospitalized for AAA as a principal diagnosis. During the same period, all death certificates mentioning AAA as an initial cause of death were included in the study. Crude and standardized rates were calculated according to age and sex. Poisson regression was used to analyze the average annual percent change. Results In 2013, there were 8 853 patients hospitalized for AAA in France (7 986 unruptured and 867 ruptured). Between 2002 and 2013, the rate of patients hospitalized for unruptured AAA decreased slightly in men (−5.0%) but increased in women (+5.2%). By contrast, the rate of patients hospitalized for ruptured AAA has decreased by more than 20% in men and women. The proportion
06-Arterial hypertension and vascular disease of endovascular treatment of unruptured AAA rose from less than 10% in 2005 to 35% in women and 40% in men in 2013. In 2013, 939 deaths from AAA were recorded. Mortality for this disease declined significantly from 2002 to 2013 in men and women. Conclusion The unfavorable epidemiological trends in women and important evolution of the management of AAA call for an epidemiological surveillance of this disease. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2017.11.216
January 19th, Friday 2018 470
Mitral valve phenotype in vascular Ehlers Danlos syndrome S. Zarka 1 , A. Rossi 2 , S. Abouth 2 , M. Frank 2 , G. Goudot 2 , X. Jeunemaitre 2 , T. Mirault 2 , E. Messas 1,∗ 1 Médecine vasculaire, hôpital Européen Georges-Pompidou 2 Médecine vasculaire, HEGP, Paris, France ∗ Corresponding author. E-mail address: [email protected] (E. Messas) Background Vascular Elhers-Danlos syndrome (vEDS) is a genetic vascular disease, affecting the production of the collagen type III, a component of the arterial wall, but also in the mitral valve (MV). Some small families studies suggest an association between vEDS and mitral valve prolapse [MVP] but a complete evaluation of MV phenotype on vEDS cohort was never performed. Purpose To describe the MV phenotype in a population of vEDS. Methods A total of 45 patients with vEDS, with characterized mutation of the COL3A1 gene, were included in a prospective singlecenter study and assessed by echocardiography. Results Among the 45 patients, no MVP was found. MV floppy was observed in 6 patients (13%) but the mean MV thickness of 2.7 ± 0.1 mm for all the group was not above normal (normal values [NV] < 3 mm). MV billowing was observed in 2 patients (4%).35 patients (78%) had mitral insufficiency but none were more than mild (trace 26 [58%] and mild 9 [20%]) and there was no mitral stenosis (mean mitral gradient = 1.31 ± 1 mmHg). Anterior leaflet length was 24 ± 0.5 mm (vs. NV = 22—23 mm), posterior leaflet length was 13.7 ± 0.3 mm (NV = 12—13 mm) and strut chordae length was 20.4 ± 1 mm (NV < 20 mm). Mitral annulus (MA) diameter was 33.1 ± 0.6 mm in the parasternal long axis view (PSLAV) (NV = 31.5 ± 0.5 mm) and 33.7 ± 0.6 mm in apical 4 chambers view (A4CV) (NV = 30.5 ± 0.4 mm) for men. In women, MA diameter was 30.4 ± 0.5 mm in PSLAV (NV = 28.3 ± 0.4 mm) and 29.5 ± 0.6 mm in A4CV (NV = 27.7 ± 0.3 mm). The ratio between MA diameter and the mitral anterior leaflet height was calculated at 1.3 ± 0.03 (NV < 1.3). Two case of ruptured mitral chordae with a previously normal echocardiographic MV were observed. Conclusion Through a single cohort of vEDS, there was no evidence of MVP despite cases of chordal ruptured. MA and mitral leaflets were larger than the classical published value. More studies are needed to better characterized the biomecanic of the MV apparatus explaining the rare occurrence of MV chordae rupture. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2017.11.217
107 328
Influence of the Sievers type and valvular functional impairment in bicuspid associated aortopathy in a prospective series G. Goudot 1,∗ , T. Mirault 2 , A. Rossi 2 , J. Albuisson 3 , S. Zarka 2 , J.M. Mazzella 3 , X. Jeunemaitre 3 , M. Pernot 1 , E. Messas 2 1 Inserm U979, institut Langevin 2 Médecine vasculaire, hôpital Européen Georges-Pompidou 3 PARCC Inserm U970, Paris, France ∗ Corresponding author. E-mail address: [email protected] (G. Goudot) Objective Bicuspid aortic valve (BAV) is associated with high incidence of ascending aortic aneurysm. In BAV sporadic form, changes in outflow’s hemodynamic secondary to the valvular morphotype are said to play a prominent role in the aortic dilatation. We aimed at comparing the different ascending aorta segment diameters according to the morphotype and the function of the BAV. Methods We evaluated 174 patients with sporadic BAV by transthoracic echocardiography. The valvular function was defined as either Aortic Insufficiency (AI) if Grade ≥ 2 and aortic Stenosis (AS) if mean gradient > 20 mmHg. Aortic diameters were measured at the Valsalva sinus, tubular ascending aorta and at the aortic arch. Kruskal-Wallis, Mann—Whitney and Spearman tests were used for comparisons. Results Among the non-operated patients, Sievers’ morphotype was type 1LR for 63%, type 1NR for 18%, and other types counted for 19%. The Valsalva sinus diameter did not differ according to the Sievers’ type (P = 0.78). The type 1LR type compared to the type1NR appeared to have a wider tubular aorta, but not significantly (42.3 ± 8.5 vs. 36.4 ± 7.3 mm; P = 0.06). Aortic valve function was distributed as follows: AI: 39%, AS: 20%, Both: 9%, Normal: 32%. Comparison of the different valve dysfunctions revealed a difference at the Valsalva (P < 10—4) and the tubular aorta (P = 0.001) but not at the aortic arch level (P = 0.62). AI was highly associated with an increase of the aortic diameters of any segment, excepting for the arch. In addition, aortic diameters increased with age in case of AI (Valsalva: r = 0.28; P = 0.02; Tubular aorta: r = 0.27; P = 0.02) and not in case of AS (r = —0.06; P = 0.73 and r = —0.03; P = 0.84). Conclusion Our results showed the tremendous role of AI in the aortic dilation of all segments except the arch. However no influence of BAV morphotype was noticed on aortic diameters. Our results give rise to the relatively limited influence of the valvular morphology in the development of aortic dilation. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2017.11.218 182
Biomarker and cardiovascular profiles of healthy aging, putting multiple biomarkers in perspective S. Bouajila 1,2,∗ , K.J. Moneghetti 1,2 , Y. Kobayashi 1,2 , F. Abbasi 2 , F.A. Gomari-Grisar 3 , T. Kuznetsova 1,4 , J.C. Wu 1,2 , F. Haddad 1,2 1 Stanford cardiovascular institute, Stanford, CA 2 Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States 3 Department of Internal Medicine II, Division of Cardiology and Angiology, Medical University of Vienna, Vienna, Austria 4 Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium ∗ Corresponding author. E-mail address: [email protected] (S. Bouajila)