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Tribute
Metabolism Clinical and Experimental VOL. XIX, NO. 10
OCTOBER,
1970
Fabian Bachrach
Tribute DRESENTING TED ASTWOOD WITH THIS FESTSCHRIFT seemed _L like a good idea in the beginning, but now that it can no longer be a private affair, we have realized too late what an onerous task it is to pay public tribute to such a master. Ted’s contributions to experimental and clinical endocrinology are unsurpassed in scope and importance and he has contributed heavily to the scientific maturation and subsequent careers of an extraordinary number of investigators who have made major contributions to endocrinology either while working in his laboratories, or later as a result of their training under his guidance. The citation for the Koch Award aptly summarized his personal contributions: METABOLISM,~OL. 19,No. 10 (OCTOBER),1970
721
722
TRIBUTE
“His publications are a record of his unusual versatility and of the diversity of his achievement in endocrine research. He studied the hormonal control of the mammary gland; he showed the rapid effect of estrogen on uterine water content; he devised a better method for measuring pregnanediol in the urine; he showed the requirement for a separate luteotrophic factor to maintain corpus luteum function in the rat and coined the name luteotropin; he purified corticortropin far beyond previous efforts, devising the method that is still the standard procedure for the commercial production of ACTH; he studied the extraadrenal metabolic effects of corticotropin and he isolated pituitary peptides which mobilize fatty acids. “Perhaps supreme among Dr. Astwood’s accomplishments was the brilliant series of studies on the chemical manipulation of thyroid function culminating in his demonstration that hyperthyroidism could be controlled with antithyroid drugs. He went on to show that certain foodstuffs have antithyroid activity and may contribute to the pathogenesis of endemic goiter; and with the precise definitiveness that characterizes his work, he proceeded to isolate from the yellow turnip L-$vinyl-2-thioxazolidone, a compound as potent as thiouracil in antithyroid action. For years, Dr. Astwood patiently insisted that an encounter between physician and a thyroid nodule was not cause for panic. His reminders that thyroid cancer is an infrequent cause of death and that nodules often shrink when thyroid hormone is administered have greatly influenced the clinical attitude towards this subject.” In his laboratories, the isolation of parathormone was achieved; a method was devised on the purification of growth hormone and was used to prepare the first human growth hormone administered to man; the standard method for the assay for the long-acting thyroid stimulator was developed there, as was a method for the extraction and purification of placental lactogen. He is held in the highest regard by those of us who are fortunate enough to share his remarkable career for many reasons-his genius, spirit of unending inquiry, humility, and patience and kindnesses extended to us so willingly. It is we who are honored to present this volume to Ted both as a personal tribute and in recognition of him as one of the outstanding endocrinologists of his time. FORMER FELLOWS AND COLLEAGUES
A. S. ANDERSON, Honolulu, Hawaii B. G. ANDERSON, Orange, Calif. C. L. ASCUNSION, Manila, Philippines G. D. AURBACH, Bethesda, Md. R. M. BARAKAT, Skraz, Iran R. J. BARRETT, Randolph, Vt. W. S. BARRY, Cleveland, Ohio J. C. BECK, Montreal, Canada R. N. BECK, Saskatchewan, Canada A. BORELLI, $50 Paulo, Brazil G. A. BRAY, Boston, Mass.
J. BROWN, Los Angeles, Calif. C. E. CASSIDY, Boston, Mass. B. J. CLARK, Pearl River, N. J. P. N. CHEIFETZ, London, England A. CLEROUX, Montreal, Canada H. W. COHEN, Minneapolis, Minn. C. B. CROW, Birmingham, Ala. C. CURTISS, Cuyahoga, Ohio W. W. DRUMMY, JR., Terre Haute, Ind. R. L. EDDY, Temple, Texas
723
TRIBUTE J. H. EDMONDSON,Staten Island, N. Y.
D. S. MUNRO, Sheffield, England
M. G. ETTLINGER,Austin, Texas A. FRIEDMAN, Washington, D. C. H. FRIESEN, Montreal, Canada T. F. GALLAGHER, JR., Boston, Mass. D. J. GALTON, London, England J. R. GIVENS, Memphis, Term. J. GLENNON, Boston, Mass. M. S. GOLDSTEIN, Chicago, 111. H. M. GOODMAN, Boston, Mass. W. GRANT, Los Angeles, Calif. M. A. GREER, Portland, Ore. J. M. HERSHMAN, Birmingham, Ala. C. H. HOLLENBERG, Toronto, Canada M. IRIE, Tokyo, Japan G. JAGIELLO,Chicago, Ill. A. E. JONES, Washington, D. C. N. KALANT, Montreal, Canada H. KELER, Ankara, Turkey T. KONO, Kyoto, Japan C. KORDON,Paris, France R. LANDOLT, Zurich, Switzerland M. P. LAUNAY, Montreal, Canada G. H. LEE, Wilmington, Del. A. E. LEWIS, Philadelphia, Pa. N. A. LINDSEY, Houston, Texas J. H. LONDONO, Gainesville, Flu. R. D. MCINROY, Harrisburg, Pa. J. M. MCKENZIE, Montreal, Canada H. MAGENDANTZ, Cleveland, Ohio E. MARTINEZ, San Juan, Puerto Rico W. E. MAYBERRY, Rochester, Minn. K. E. W. MELVIN, Boston, Mass. R. P. MILLER, Warminster, Pa. M. L. MITCHELL, Boston, Mass. A, MORRISON,Boston, Mass. M. MORRISON,Montreal, Canada
S. S. MURPHY, Montreal, Canada W. A. MURPHY, Boston, Mass. Y. NAKANO, Kyoto, Japan J. F. OTTO, Huntington, W. Vu. W. PARSON,JR., Cleveland, Ohio I. PASTAN, Bethesda, Md. D. PATTEN, Boston, Mass. J. PATTERSON,Boston, Mass. R. W. PAYNE, Oklahoma City, Okla. D. G. PENINGTON, Melbourne, Australia M. S. RABEN, Boston, Mass. R. S. REISS, San Francisco, Calif. I. N. ROSENBERG,Boston, Mass. P. ROSENFELD, Wood, Wise. B. RUEDI, Lausanne, Switzerland R. J. RYAN, Rochester, Minn. S. SAIDUDDIN,Boston, Mass. R. SAPERSTEIN,Boston, Mass. C. T. SAWIN, Boston, Mass. W. D. SLINGERLAND,Boston, Mass. R. L. SOFFER, Bronx, N. Y. D. H. SOLOMON, Torrance, Calif. M. M. STANLEY, Chicago, Ill. V. M. STORRIE, Winnipeg, Canada Y. SUGANO,Kochi-Ken, Japan I. D. THOMAS, Sydney, Australia W. P. VANDERLAAN, LaJolla, Calif. L. VAN MIDDLESWORTH,Memphis, Tenn. 0. S. WERMER, Cambridge, Mass. V. W. WESTERMEYER, Santa Barbara, Calif. J. WOLFF, Bethesda, Md. T. YAMADA, Maebashi, Japan D. A. YORK, Boston, Mass.
OCTOBER,
1970
Fabian Bachrach
Tribute DRESENTING TED ASTWOOD WITH THIS FESTSCHRIFT seemed _L like a good idea in the beginning, but now that it can no longer be a private affair, we have realized too late what an onerous task it is to pay public tribute to such a master. Ted’s contributions to experimental and clinical endocrinology are unsurpassed in scope and importance and he has contributed heavily to the scientific maturation and subsequent careers of an extraordinary number of investigators who have made major contributions to endocrinology either while working in his laboratories, or later as a result of their training under his guidance. The citation for the Koch Award aptly summarized his personal contributions: METABOLISM,~OL. 19,No. 10 (OCTOBER),1970
721
722
TRIBUTE
“His publications are a record of his unusual versatility and of the diversity of his achievement in endocrine research. He studied the hormonal control of the mammary gland; he showed the rapid effect of estrogen on uterine water content; he devised a better method for measuring pregnanediol in the urine; he showed the requirement for a separate luteotrophic factor to maintain corpus luteum function in the rat and coined the name luteotropin; he purified corticortropin far beyond previous efforts, devising the method that is still the standard procedure for the commercial production of ACTH; he studied the extraadrenal metabolic effects of corticotropin and he isolated pituitary peptides which mobilize fatty acids. “Perhaps supreme among Dr. Astwood’s accomplishments was the brilliant series of studies on the chemical manipulation of thyroid function culminating in his demonstration that hyperthyroidism could be controlled with antithyroid drugs. He went on to show that certain foodstuffs have antithyroid activity and may contribute to the pathogenesis of endemic goiter; and with the precise definitiveness that characterizes his work, he proceeded to isolate from the yellow turnip L-$vinyl-2-thioxazolidone, a compound as potent as thiouracil in antithyroid action. For years, Dr. Astwood patiently insisted that an encounter between physician and a thyroid nodule was not cause for panic. His reminders that thyroid cancer is an infrequent cause of death and that nodules often shrink when thyroid hormone is administered have greatly influenced the clinical attitude towards this subject.” In his laboratories, the isolation of parathormone was achieved; a method was devised on the purification of growth hormone and was used to prepare the first human growth hormone administered to man; the standard method for the assay for the long-acting thyroid stimulator was developed there, as was a method for the extraction and purification of placental lactogen. He is held in the highest regard by those of us who are fortunate enough to share his remarkable career for many reasons-his genius, spirit of unending inquiry, humility, and patience and kindnesses extended to us so willingly. It is we who are honored to present this volume to Ted both as a personal tribute and in recognition of him as one of the outstanding endocrinologists of his time. FORMER FELLOWS AND COLLEAGUES
A. S. ANDERSON, Honolulu, Hawaii B. G. ANDERSON, Orange, Calif. C. L. ASCUNSION, Manila, Philippines G. D. AURBACH, Bethesda, Md. R. M. BARAKAT, Skraz, Iran R. J. BARRETT, Randolph, Vt. W. S. BARRY, Cleveland, Ohio J. C. BECK, Montreal, Canada R. N. BECK, Saskatchewan, Canada A. BORELLI, $50 Paulo, Brazil G. A. BRAY, Boston, Mass.
J. BROWN, Los Angeles, Calif. C. E. CASSIDY, Boston, Mass. B. J. CLARK, Pearl River, N. J. P. N. CHEIFETZ, London, England A. CLEROUX, Montreal, Canada H. W. COHEN, Minneapolis, Minn. C. B. CROW, Birmingham, Ala. C. CURTISS, Cuyahoga, Ohio W. W. DRUMMY, JR., Terre Haute, Ind. R. L. EDDY, Temple, Texas
723
TRIBUTE J. H. EDMONDSON,Staten Island, N. Y.
D. S. MUNRO, Sheffield, England
M. G. ETTLINGER,Austin, Texas A. FRIEDMAN, Washington, D. C. H. FRIESEN, Montreal, Canada T. F. GALLAGHER, JR., Boston, Mass. D. J. GALTON, London, England J. R. GIVENS, Memphis, Term. J. GLENNON, Boston, Mass. M. S. GOLDSTEIN, Chicago, 111. H. M. GOODMAN, Boston, Mass. W. GRANT, Los Angeles, Calif. M. A. GREER, Portland, Ore. J. M. HERSHMAN, Birmingham, Ala. C. H. HOLLENBERG, Toronto, Canada M. IRIE, Tokyo, Japan G. JAGIELLO,Chicago, Ill. A. E. JONES, Washington, D. C. N. KALANT, Montreal, Canada H. KELER, Ankara, Turkey T. KONO, Kyoto, Japan C. KORDON,Paris, France R. LANDOLT, Zurich, Switzerland M. P. LAUNAY, Montreal, Canada G. H. LEE, Wilmington, Del. A. E. LEWIS, Philadelphia, Pa. N. A. LINDSEY, Houston, Texas J. H. LONDONO, Gainesville, Flu. R. D. MCINROY, Harrisburg, Pa. J. M. MCKENZIE, Montreal, Canada H. MAGENDANTZ, Cleveland, Ohio E. MARTINEZ, San Juan, Puerto Rico W. E. MAYBERRY, Rochester, Minn. K. E. W. MELVIN, Boston, Mass. R. P. MILLER, Warminster, Pa. M. L. MITCHELL, Boston, Mass. A, MORRISON,Boston, Mass. M. MORRISON,Montreal, Canada
S. S. MURPHY, Montreal, Canada W. A. MURPHY, Boston, Mass. Y. NAKANO, Kyoto, Japan J. F. OTTO, Huntington, W. Vu. W. PARSON,JR., Cleveland, Ohio I. PASTAN, Bethesda, Md. D. PATTEN, Boston, Mass. J. PATTERSON,Boston, Mass. R. W. PAYNE, Oklahoma City, Okla. D. G. PENINGTON, Melbourne, Australia M. S. RABEN, Boston, Mass. R. S. REISS, San Francisco, Calif. I. N. ROSENBERG,Boston, Mass. P. ROSENFELD, Wood, Wise. B. RUEDI, Lausanne, Switzerland R. J. RYAN, Rochester, Minn. S. SAIDUDDIN,Boston, Mass. R. SAPERSTEIN,Boston, Mass. C. T. SAWIN, Boston, Mass. W. D. SLINGERLAND,Boston, Mass. R. L. SOFFER, Bronx, N. Y. D. H. SOLOMON, Torrance, Calif. M. M. STANLEY, Chicago, Ill. V. M. STORRIE, Winnipeg, Canada Y. SUGANO,Kochi-Ken, Japan I. D. THOMAS, Sydney, Australia W. P. VANDERLAAN, LaJolla, Calif. L. VAN MIDDLESWORTH,Memphis, Tenn. 0. S. WERMER, Cambridge, Mass. V. W. WESTERMEYER, Santa Barbara, Calif. J. WOLFF, Bethesda, Md. T. YAMADA, Maebashi, Japan D. A. YORK, Boston, Mass.