Twice monthly bibliography on prostaglandins biology- early December prepared by Sheffield university biomedical information service Sheffield S10 2TN

‘IWICE MONTHLY BIBLIOGRAPHY ON PROSTAGLANDINS BIOLOGY- EARLY DECEMBER PREPARED BY SHEFFIELD UNlVERSITY BKHWEDICAL INFORMATION SERVICE SHEFFIELD SlO 2TN 1. BOORS, REvlEws,SYMPOSIA Hanaaaki K, A&a I-I// Shiiogi Res Lab, Shiononi & co Ltd. Fukushhima-ku. Osaka 553, Jabs PLATELEI-S (EDINBURGH) 1991,2 (2) 69-76 Recent aspects of TKA2 action on platlets and blood bessels (Review) Smith BJ, Curtis JF, EJing TEW NIEHS, Mokc Biophys Lab, Ekosanoid Biochem Sect, POB 12233, Res Triangle Pk. NC 27709,

USA

CHEM-BIOL INTER 1991,79 (3) 245 Bioactivation of xenobiotics by prostaglandinH-synthase (Review Article) Schewe T, Kuhn HJ/ Inst B&hem, Med Sch (Char&e), Humboldte Univ, Hessiche Stmsse 34, O-1040 Berlin, FRG TRENDS BIOCHEM SCI 1991,16 (10) 369 Do lS-lipoxygenases have a common biological role? (TIBS Review) Schror K// Univ Dusseldorf, Inst Pharmackol, Moorenstr 5, W-lOtkl Dusseldorf 1, FRG WIEN KLIN WOCHENSCHR 1991,103 (18) 543 Thromboxane antagonism in platelets - Pathophysiology, pharmacology and possible clinical relevance (Review) (German) Kiylov YF, Lyubimov IB, Mulyar AG// NV Semashko Med Stomatol Inst, Moscow, USSR KHIM-FARM ZH SSSR 1991,s (9) 4 Use of eicoaapentaenoic and docarahexaenoic acids as dtugs - prospects (a IwieW) (Russian) Kudo I// Univ Tokyo, Fat Pharmaceut Sci, 73-1 Hongo, Bunkyo ku, Tokyo 113, Japan YAKUGAKU ZASSHI J PHARM SOC J 1991,111(9) 488 Mammalian cellular phospholipasesA2 and their physiological roles (Review) (Japanese)

2. GENERAL Weiss K, Katxenschlager R, Egert H, Cajka P, Sinxinger H/I Wilhelm Auemwald Atherosklemaefotsch Grp Wien, Nadler Gasse 1, A1090 Vienna, Austria WIEN KLIN WOCHENSCHR 1991,103 08) 566 Risk factors of atherosclerosis - Results of a screening investigation in lower Austria (German)

PRECURSORS 4. Aracbidonic Acid Grauholt AM, Steffensen R, Host NB, Grande P// Dept Med B, Rigshospitalet, Univ Copenhagen, Bkgdamsvej 9, DK-2100 Copenhagen 0, Denmark P&A‘$ELETS (EDINBURGH) 1991,2 (1) Arachidonic acid-induced platelet aggregation ex viva in patients with acute ischacmic heart disease. Golubic M, Tanaka K, Dobtcwolski S, Wood D, Tsai MH. Marshall M. Tamanoi F, Staeev DW// Dept MoI Biol, Cleveland Cl& Pot&dation, 9SOOEuclid Ave/NC2-lS0, Cleveland, Oh 441955285, USA

EMBO J 1991,lO (10) #)97 ‘Ihe GTPase stimulatory activities of the neurofibromatosis type I and the yeast IRA2 proteins are inhibited by arachidonic acid. Felder CC, Williams HL, Axelrod J// Lab Cell Biol, Bldg 36, Rm 3A-IS, Nat Inst Mental Hlth. Bethesda. Md 20892. USA PROC NAT ACAD SCI usA 1991,838 (is)

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A transduction pathway associated with receptom coupled to the inhibitory guanine nucleotide binding protein Gl that amplifies A’IP-mediated arachidonic acid release. Ramis I, Rosellccatafau J, Gomez G, Zabay JM, Crux EF, Gelpi E*// lCSIC, Ctr Invest & Desarrollo, Eicosanoid Branch, Dept Neurochem, Jordi Girona 18-26, E-OS034 Barcelona, Spain J CHROMATOGR 1991,557 (l-2) 507 Cyclooxygenase and lipoxygenase arachidonic acid metabolism by monocytes from human immune deficiency virus-infected drug users. MacEwan DJ, Mitchell R*, Thomson FJ, Johnson MS// lMRC, Brain Metab Unit, 1 George Sq, Edinburgh EH8 9JZ, Scotland BIOCHIM BIOPHYS ACTA 1991,1094 (3) 346 Inhibition of depolarisation-induced calcium influx into GH3 cells by arachidonic acid The involvement of protein kinase-C, Nagao M, Ishii S, Kitamura K, Akino T*// ‘Sapporo Med Coil, Dept Biochem, S 1, W 17, Chuo ku, Sapporo, Hokkaido 060, Japan CLIN ORTHOP RELATED RES 1991 (271) 288 Arachidonic acid metabolism in articular chondrocytes. Oomagari K, Buisson B. Dumuis A, Bockaert i, Pin JP*// *Salk Inst Biol Studies, Molec Neurobiol Lab H. POB &%OO.San Diego, Ca 92186, USA ’ EUR J NEUROSCI 1991,3 (10) 928 Effect of glutamate and ionomycin on the release of arachidonic acid, prostaglandins and hetes from cultured neurons and astrocytes. Pellerin L, Wolfe LS*// *McGill Univ, Montreal Neurol Inst, Donner Lab Exptl Neurochem, 3801 Univ St, Montreal, Quebec, Canada H3A 2B4 NEUROCHEM RES 1991,16 (9) 983 Release of arachidonic acid by NMDA-receg tor activation in the rat hippocampus. Shinmen Y, Katoh K, Shimixu S’, Jareonkitmongkol S, Yamada H// lKyoto Univ. Dept Agr ?hem, Sakyo ku, Kyoto 606, Japan _ PHYTOCHEMISIRY 1991.30 (10’13255 Production of arachidonic acid aid kicosapentaenoic acids by Marchantia polymorpha in cell culture. Ferretti A, Nelson GJ, Schmidt PC// USDA ARS, Beltsville Agr Res Ctr, BeItsville Human Nutr Res Ctr, Lipid Nutr Lab, Room 123, Bldg Jos, Beltsvilk, -Md 20705, USA J NUTR BIOCHEM 1991.2 (10) 547 Salmon-rich diet inhibits &&donate cyclooxygenation in healthy men. Balsinde J, Diex E, Mollinedo F*// lCentro Invest Biol, Consejo Super Invest Cientif, Ve-

laxquex 144, E-2lIOO6Madrid, Spain J BIOL CHEM 1991,266 (24) 15638 Arachidonic acid release from diacylglycerol in human neutrophils. Translocation of diacylglyceroldeaqlating enzyme activities from an intracellular pool to plasma membrane upon cell activation. Cambria RA, Anderson RI, Dikdan G, Lysx TW, Hobson RW*// lUniv Med Bt Dent New Jersey, New Jersey Med Seh, Vast Surg Sect, 185 S Orange Ave, MSB G532, Newark, NJ 07103, USA J VASC SURG 1991.14 (4) 549 The influence of arachidonic acid metabolites on leukocyte activation and skeletal muscle injury after ischemia and reperfusion. 5. PROSTAGLANDINS E AND F Weinhold L, Schulxespecking A, Decker K // Univ Freiburg, Inst B&hem, Hermann Herdemtr 7, W-7800 Freiburg, FRG BIOL CHEM HOPPE-SEYLER 1991,372 (9) 829 Signal transduction in endotoxin-stimulated synthesis of TNF-alpha and prostaglandinE2 by rat Kupffer cells - Rok of extracellular calcium ions and protein kinase-C. Estevez AG, Calamante G, Goin M, Deasua IJ’N *Inst Invest Ingn Genet & Biol Molec, Obligado 2490, RA-1428 Buenos Aires, Argentina FEBS LEIT 1991,290 (l-2) 239 Tunicamycin inhibits the initiation of DNA synthesis stimulated by proataglandin-F2alpha in Swiss mouse 3T3 cells. Dimarco NM, Rule DC, Whitehurst GB, Beitx DC*// ‘Iowa State Univ Sci & Technol, Dept Anim Sci, Ames, Ia 50011, USA INT J BIOCHEM 1991,23 (11) 1231 Effect of indomethacin, epinephrine, prostaglandin E-2 and insulin on lipolysis in bovine adipose tissue in vitro. Bahviercxak JU/ Ciba Geigy Corp. Res Dept, Div Pharmaceut, Summit, NJ OMl, USA _ BRITJP HARMACOL 1991.104 12’1373 The relationship of KU-mediated and prostaglandin F-2-alpha-mediated increases in tension of the porcine coronary artery with changes in intracellular Ca-2 + measured with furad. Giles H, Bolofo ML, Lydford SJ, Martin GR// Wellcome Rea Labs. Analvt Pharmacol Grp, Langley Court, Beckenham BR3 3BS, Kent, England BRlT J PHARMACOL 1991,104 (2) 541 A comparative study of the prostanoid receptor profile of 9-alpha-11-beta-prostaglandin F-2 and prostaglandin D-2. Gobbetti A, Zenmi M, Mosconi G, Botte V // Univ Camerino, Dept Cellular Biol, Via F Camerini 1, I-62032 Camerino, Italy GEN COMP ENDOCRINOL 1991,84 (1) 9 Effects of mammalian gonadotropin-releasing hormone on plasma level of prostaglandinF2alpha in the water frog, Rana esculenta. Pugh S// Univ Hoep Wales, Dept Gastroenterol, Heath Pk, Cardiff, Wales INT J EXP PATHOL 1991,72 (5) 563

A fall in duodenal PGE2 synthesis precedes histological changes and ulceration in the cysteamine model of duodenal ulceration. Goodman SB, Chin RC, Chiou SS, Lee JS// Stanford Univ, Med Ctr, Div Orthopaed Sure R171.300 Pasteur Dr. Stanford, Ca

Stein SH, Phipps RP*// lUniv Rochester, Sch Med, Ctr Cant, Box 704,601 Elmwood Ave, Rochester, NY 14642, USA J IMMUNOL 1991,147 (8) 2500 Antigen+pecitic IgG2a production in response to pmstagIandinE2, immune complexes, and IFN-gamma.

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CLIN ORTHOP RELATED RES 1991 1271) 300 Suppression of pmstagIandinE2 synthesis in the membrane surrounding particulate poIymethylmethacrylate in the rabbit tibia. May SA, Hooke RI?.,Lees P// Univ Liverpool, Div Equine Studies, Vet Field Stn, Wirral I-64 7IE, Meme-yside, England EQUINE VEI J 1991,23 (5) 380 Adverse conditions in vitro stimulate chondmcytes to produce prostaglandin E2 and stmmelysin. Hesse WH, Rudofsky G, Peskar BA*// *Ruhr Univ Bochum, lnst Pharmacol & Toxikol, Univ Str 150, W4630 Bochum, FRG WIEN KLIN WOCHENSCHR 1991,103 (18) 554 Metabolism of prostaglandin-El administered intravenously to patients with peripheral arterial occlusive disease (German) Befrits R, AIy A, Musat A, Green K, Johansson c// Kamlinska Hosp, Med Chn, S-10401 Stockholm 68, Sweden EUR J GASI’ROENTEROL HEPATOL 1991,3 (10) 763 Autoregulation of gastric acid secretion in healthy subjects and duodenal ulcer Possible relation to local prostaglandin E2 formation. Hata F, Kishi I, Saeki K, Takeuchi T, Yagasaki 011 Univ Osaka Prefecture, Co11Agr, Dept Vet Pharmacol, Sakai, Osaka 591, Japan NEUROPHARMACOLOGY 1991,30 (10) 1107 PmstagIandinE2 selectivity affects purinergic transmission in guinea pig vas deferens. Barilan A, Naveh N*, Weissman C, Belkin M, Schwartz M// *Tel Aviv Univ, Chaim Sheba Med Ctr, Sackler Fat Med, Maurice & Gabriela Goldschleger Eye Res Inst, Tel Hashomer, Israel _ NEUROSCIENCE 1991.45 11) 221 ProstagIandinE2 changes in ihe retina and optic nerve of an eye with injured optic nerve. Obyme EM, Blancuzzi V, Wilson D, Wong M, Peppard J, Simke JP, Jeng AY// Ciba Geigy Corp. Dept Res, Div Pharmaceut, 556 MO&~ A$ Summit, NJ 07901, USA AGENT ACTION 1991.34 11-2) 46 Effects of indomethacin; tri~mciholone, and dexamethasone on recombinant human interlet&in-l-induced substance-P and prostaglandin E2 levels in rabbit knee joints. Tamura K, Okamoto R, Take0 S, Kogo H’// lTokvo Coil Pharm. Dept Pharmacol, 1432-1 Ho&ouchi, Hachioji, Tokyo 19203, Japan EUR J PHARMACOL 1991.202 (3) 317 Inhibition of the first ovulation and ovarian prostaglandin-F2-alpha metabolism by danazol in rats. EIkashab M, Lala P’// lUniv Western Ontario, Dept Anat, London, Ontario, Canada N6A SC1 IMMUNOL LEIT 1991,30 (1) 7 PGE2 receptors on murine splenic lymphocytes - effects of tumor bearing.

Ueno T, Yokomise H, Oka T, Puskas J, Mayer I?, Slut&y AS, Patterson GA’// lDiv Cardiothorac Surg, Suite 3108, Queeny Tower, 1 Barnes Hasp Plaza, St Louis, MO 63110, USA TRANSPLANTATION 1991,52 (4) 626 The effect of PGEl and temperature on lung function following preservation. Wuwang CY, Wang SL, Yao P, Slomiany A, Slomiany BIJ/ Univ Med & Dent New Jersey, New Jemey Dent Sch, Res Ctr, Newark, NJ 07103, USA ARCH ORAL BIOL 1991,36 (9) 637 PmstagIandinE2 receptor of rat submandibular saliiry glands. Jee WSS, Ke HZ, Li XI// Univ Utah, Sch Med, Div Radiobiol, Bldg 586, Salt Lake City, Ut 84112, USA BONE MINER 1991,15 (1) 33 Long-term anabolic effects of prostaglandinE2 on tibia1 diaphyseal bone in male rats. Weng K, Mathiot C*, Lando D, Fridman WI-I // lInst Curie. INSERM. U255. Hematol Lab,.26 Rue UIm,‘F-75231 Paris, France CANCER J 1991,4 (5) 307 Inhibition of LAK cells by II&activated monocytes - role of TGF-beta and PGE2. Randall CL, Anton RF, Becker HC, Hale RL. Ekblad U// Vet Adm Med Ctr. Charleston; SC 29403; USA TERATOLOGY 1991,44 (5) 521 Aspirin dosedependentIy reduces alcohol-induced birth defects and pmstaglandin-E levels in mice.

6. PROSTACYCLIN Weiss K, Fitscha P, Virgolini I, O’Grady J, Sinzinger W/ Atherosclerosis Res Grp (ASF) Vienna, Schwarzpanierstr 17, A-1090 Vienna, Austria PLATELEIS (EDINBURGH) 1991,2 (1) 4143 Influence of a single dose of calcium channel blockers on platelet function. Hark A J MAL VASCUL 1991,16 (3) 308 Pmstacyclin for critical ischemia (French) Masik G, KiraIy A, Garamsxegi M, Javor T, Nasv L. Suto G. Toth G. Vincze A// Med U& P&s, Dept Med 1, &sag 13, H-7643 Pets, Hungary LIFE SCI 1991,49 (19) 1383 Failure of prostacyclin, beta-carotene, atmpine and cimetidine to produce gastric cyto-mucosal and general-mucosal protection in surgicahy vagotomized rata. Watson JE, Karmazyn M*// lUniv Western Ontario, Dept Pharmacol & Toxicol, Med Sci Bldg, London, Ontario, Canada N6A 5Cl CIRC RES 1991,69 (4) 1114 Concentration-dependent effects of pmtein kinase-C-activating and kinase-C-nonactivating phorbol esters on myocardial contractility, coronary resistance, energy metabolism, prostacyclin synthesis, and ultrastructure in isolated rat hearts - effects of ami-

loride. Tobe S et al NIPPON KYOBU GEKA GAKKAI ZASSHI 1991,39 (1) 20-7 The effect of PG12 and SOD on the reimplantation response after lung transplantation (Jpn, Eng Abstr) Yoshimura H et al NIPPON KYOBU GEKA GAKKAI ZASSHI 1991,39 (1) 52-8 The effect of prostaglandin 12 on the postischemic recovery of the transplanted heart under deep hypothermia (Jpn, Eng Abstr) SxiIvassy Z et al BRATISL LEK LISI’Y 1991,92 (34) 134-7 7-oxo PGI2 dramatically increases the safety margin of digitalis. Udvary E et al BRATISL LEK LISTY 1991,92 (3-4) 146-9 ‘I-oxo-PGI2 induced late protective action from arrhythmias due to local myocardial ischemia. Doron DA, Jacobowitz DM, Heldman E, Feuerstein G, Pollard HB, Hallenbeck JM /I NIDDKD, Cell Biol & Genet Lab, Bldg 8, Room 405, Bethesda, Md 28892, USA IN VITRO CELL DEVELOP BIOL 1991, 27 (9) 689 Extracellular matrix permits the expression of von Willebrand’s factor, uptake of Di-lacetylated low density lipoprotein and secmtion of pmstacyclin in cultures of endothelial cells from rat brain microvessels. ShushIyapin 01, Shelest AN, Shakhavat AFMK// Kharkov Med Inst. Chair Internal Dis, Kharkov, Ukraine, USSR KARDIOLOGIYA 1991,31(8) 39 Roxicam pharmacological modulation of the prostacyclin-thmmboxane system in heart failure-complicated acute myocardial infarction (Russian)

7. THROMBOXANES Moosa A, Ford 1, Brown CB, Greaves M*// *Reader and Consultant in Haematology, Royal Hallamshire Hosp, Glossop Road, Sheffield SlO 2JF, England y5’;“lT$LEIS (EDINBURGH) 1991,2 (3) Fibrinopeptide A, thmmboxanc B2 and betathmmboglobulin levels in bleeding time blood in uraemia. Hatmi M, Haye B, Gavaret JM, Vargaftig BB, Jacquemin c// lnst Pasteur, INSERM, U4285, Unite Pharmacol Cellulaire, 25 Rue Dr Roux. F-75724 Paris 15. France BRIT J PHARMACOL 1991,104 (2) 554 Alkaline phosphatase prevents platelet stimulation by thmmboxane-mimetics. Allermand H, Nielsen HK, Huated SE, Haverrich A, Heublein B// Univ Aarhus, Skejby Sygehus, Dept Cardiovasc Surg, DK8200 Aarhus, Denmark J HEART LUNG TRANSPLANT 1991,lO (5) 766 Plasma thmmboxane B2 as an early marker of acute graft rejection after heart transplantation - Preliminary report. Giorgadse ML, Panchenko EP, Gratsiansky NA, Masenko VA// AI1 Union Prevent Med Re.s Ctr, Infect Dis Prevent Res Inst, Moscow, USSR

KARDIOLOGIYA 1991,31(8) 7 Blood thromboxane and proataqclin from co. ronary sinus in spontaneous myocardial ischemia (Russian) Cross PE, Dickinson RP// Pfiir Ltd, Dept Discovery Chem, Sandwich CT13 9NJ, Kent, England CHEM BRfI 1991,27 (10) 911 The story of thromboxaneA2. Clarke RJ, Mayo G, Price P, Fitzgerald GA*// *Vanderbilt Univ, Div Clin Phannacol, Rm 538, Med Res Bldg, Nashville, Tn 37232, USA N ENGL J MED 1991,325 (16) 1137 Suppression of thromboxaneA2 but not of systemic prostaqclin by controlled-release aspirin. Heylen L, Declerck F, Somers Y, Leysen JE*// *Janssen Res Fdn, Dept Biochem Pharmacol, B-2348 Beeme, Belgium BLOOD COAGULAT FIBRINOL 1991,2 (5) 617 Thromboxane-A2/prostaglandin endoperoxide (TXA2/PG-END) receptor binding properties in human platelets of ridogrel, a combined TKA2 synthase inhibitor TAX2/PG-END receptor antagonist. Pittet JF, Morel DR.// *Hop Cantonal Geneva, Dept Anesthesiol, CH-1211 Geneva 4, Switzerland CIRC SHOCK 1991,35 (2) 65 Imbalance between plasma levels of thromboxane-B2 and 6-keto-prostaglandin-Flalpha during subacute endotoxin-induced hyperdynamic sepsis or multiple organ failure syndrome in sheep. Serruys PW, Rutsch W, Heyndrickx GR, Danchin N, Mast EG, Wijns W, Rensing BJ, Vos J, Stibbe J// Erasmus Univ, Thoraxctr, Catheterirat Lab, POB 1738,300O DR Rotterdam, Netherlands CIRCULATION 1991,84 (4) 1568 Prevention of restenosis after percutaneous transluminal coronary angioplasty with thromboxaae A2-receptor blockade - a randomized, double-blind, placebo-controlled trial. 8. LEUKOTRIENES Cooper AL, Rothwell NJ// Dept Physiol Sci, Univ Manchester, Oxford Rd, Manchester Ml3 SPI’, England J PHYSIOL (LOND) 1991,438 308 The involvement of centrally released eicosanoids and corticotrophin-releasing factor (CRF) in the metabolic and pyrogenic responses to injury and inflammation in the conscious rat (Abstract) Lehr HA, Hubner C, Nolte D, Kohlschutter A, Messmer K// Inst Surg Res, Univ Munich, 8000 Munich 70, FRG PROC NAT ACAD SCI USA 1991,88 (15) 67266730 Dietary fsh oil blocks the microcirculatory manifestations of ischemia-reperfusion injuly in striated muscle in hamsters. Hemnann W, Biermann J, Hanf S, Lindhofer HG, Koatner GM, Beik J. Reuter W// Univ Reg&sburg, Inst Klin Chem & Lab Med, FJ Strauss Allee, W-8400 Regensburg, p&N MED-ZKM 1991,46 (19) 1363 Fish oil diet with high n-3 PUFA levels for cardiovascular patients - E&&s on serum

concentrations of lipids, L&a), fmrinolysis and blood pressure (German) Iglesias JLM, Dabila FH, Marino JIM, Gorrdillo CD*. Exwaito JM// lUniv Extremadura, Fat Sci, D&t Biochem Molec Biil & Genet, Avda Evas S-N, E-06071 Badajoz, Spain NAHRUNG 1991,35 (7) 705 Biochemical aspects of the lipids in Vitis vinifera grapes (Macabeo variety). 1. Linoleic and linolenic acids as aromatic precursors. Robinett RSR, Hsieh JYK*// *Merck Sharp & Dohme Ltd, W Point, Pa 19486, USA J CHROMATOGR-BIOMED APPL 1991. 570 (1) 157 Stereoselective determination of R(-)-MK571 and s( + )-MK-571. a leukotriene-D4 antagonist, ih human plasma by chiral high-performance liquid chromatography. Kasimir S, Schonfeld W, Hilpr RA, Konig W’// lRuhr Univ Bochum, Infektabwehrmechanismen Med Mikmbiol & Immunol, W4639 Bochum, FRG BIOCHEM J 1991,279 (Oft) Pt 1,283 Analysis of leukotriene-B4 metabolism in human promyelocytic HL-60 cells. Yadwad VB, Ward OP’, Noronha LC// lUniv Waterloo, Dept Biol, Waterloo, Ontario, Canada N2L 3Gl BIOTECHNOL BIOENG 1991,38 (8) 956 Application of lipase to concentrate the docosahexaenoic acid fDHA) fraction of fish oil (Letter) \ ’ Burns A, Lin YG, Gibson R, Jam&on D*// +Univ New S Wales, Sch Physiol& Phannacol, POB 1, Kensington, NSW 2033, Australia BIOCHEM PHARMA COL 1991,42 (7) 1353 The effect of a fish oil enriched diet on oxygen toxicity and lipid peroxidation in mice. Wahedna I, Wisniewski AS, Tattersfield AE// City Hosp, Resp Med Unit, Nottingham NG5 IPB, England BRlT J CLIN PHARMA COL 1991, 32 (4) 512 Effect of RG-12525, an oral leukotriene D4 antagonist, on the airway response to inhaled leukotriene D4 in subjects with mild asthma. Linden A, Ullman A, Iofdahl CG, Skoogh BE// Univ Goteborg, Lung Clin, Box 17301, S-l0264 Gothenburg, Sweden BRIT J PHARMACOL 1991,104 (2) 509 Non-adrenergic, nonsholinergic neural activation stabilizes smooth-muscle tone independently of eicosanoid factors in guinea-pig isolated airways. Islin H, Capito K*, Hansen SE, Hedeskov Cl, Thams P// lUniv Copenhagen, Panum Inst, Dept Biochem A, Blegdamsvej 3, DK2200 Copenhagen, Denmaik _ ACTA PHYSIOL SCAND 1991.143 (2) I53 Ability of omega-3 fatty acids to ‘resto;e’thk impaired glucose tolerance in a mouse model for type-2 diabetes - different effects in male and female mice. Watanabe S et al TANPAKUSHITSU KAKUSAN KOSO 1991,36 (3) 5848 Physiological significance of n-3 fatty acidcontaining phospholipids (Jpn) Anderson KM, Harris JE// Rush Med Coil, Dept Med, Med Oncol Sect, Chicago, II 69612, USA

CLIN PHYSIOL BIOCHEM 1990,8 (6) 308 5,8,11,14-Eicosatetraynoic acid inhibits PC3 DNA synthesis and cellular proliferation, in part due to its 5’-lipoxygenase activity. Chiang MT, Kimura W/ Natl Taiwan Ocean Univ, Dept Marine Food Sci, 2 Pei Ning Rd, Chilung 20224, Taiwan INT J VITAM NUlR RES 1991,61(3) 239 Effect of dietary protein on the peroxidation of eicosapentaenoic acid in stroke-prone spontaneously hypertensive rats. Parrish CC, Pathy DA, Parkes JG, Angel A*// lUniv Manitoba, Hlth Sci Ctr, Dept Internal Med, Room GG430,700 William Ave, Winnipeg, Manitoba, Canada R3E 023 J CELL PHYSIOL 1991,148 (3) 493 Dietary fish oils modify adipocyte structure and function. Vane JR Botting RM// St Bartholomews Hosp, Coil Med, William Harvey Res Inst, Charterhouse Sq, London EClM 6BQ England WIEN KLIN WOCHENSCHR 1991,103 (18) 541 The present status of eicoMnoids and related substances in the control of the cardiovascular system (German) Hillier K, Jewel1 R, Darrell I., Smith CL // Univ Southamoton. Fat Med. Clin Pharmacol Grp, Southimpton SO9 3TU, Hants, England GUT 1991,32 (10) 1151 Incorporation of fatty acids from fish oil and olive oil into colonic mucosal lipids and effects upon eicosanoid synthesis in inflammatoolybowel disease. Tomchek LA, Hartman DA, Lewin AC, Calhoun W, Chau TT, Carlson RP*// *Wyeth Ayerst Res, CN 8000, Princeton, NJ 08543, USA AGENT ACTION 1991,34 (l-2) 20 Role of corticosterone in modulation of eicosanoid biosynthesis and antiinflammatory activity by 5-lipoxygenase (S-LO) and cyclooxygenase (CO) inhibitors. Poubelle PE, Stankova J, Grassi J, Rolaplesxcqnski M// CHUL, Ctr Rech; Unite Rech Inflammat & Immunol Rhumatol. 2705 Blvd Laurier, Quebec City, Quebec, C&da GlV 4G2 AGENT ACTION 1991,34 (l-2) 42 Leukotriene B4 up-regulates IL-6 rather than IL-I synthesis in human monocytes. Bak CFX, Anderson CM, Hanglow AC, Morgan DW’II ‘Hoffmann La Roche Inc. Deot Pharmacol, Nutley, NJ 07110, USA ’ ’ AGENT ACTION 1991,34 (l-2) 81 Eicosanoid production and phospholipase A2 secretion by peritoneal macrophagec from rats with adjwant-induced arthritis. Fretland DJ, Widomski DL, Shone RI., Levin S, Gaginella TS// Searle Res & Dev, Gastrointestinal Dis Res, 4901 Searle Pkway, Skokie, II 60077, USA AGENT ACTION 1991,34 (l-2) 172 Effect of the leukotriene B4 receptor antagonist, SC-41930, on experimental allergic encephalomyelitis (EAE) in the guinea pig. Lograno MD, Mosconi C, Marangoni F, Medini L, Grassi G, Galli C’// *Univ Milan, Sch Pharm, Inst Pharmacol Sci, Via Balxaretti 9, I-20133 Milan, Italy EUR J PHARMACOL 1991,202 (3) 311

Vascular eicosanoids and platelet-aortic-wall interactions in spontaneously hypertensive rats. Nishii K, Nishiiwa Y, Nishiwa Y, Matsumoto K, Sato B*// *Osaka Univ Hasp, Dept Internal Med 3, Fukushima ku, Osaka 553, Japan CANCER RES 1991,51(20) 5573 Inhibition of murine transformed Leydig cell proliferation by feukotrienes in serum-free culture. Harding P, Stonier C, Aber GM// Univ Keefe, Sch Postgrad Med & Biof Sci, Renal Res Labs, Tftomburrow Dr, Stoke on Trent ST4 7QB, Staffs, England CLIN SC1 1991,81(4) 491 Effect of angiotensin-converting enzyme inhibitors on gfomerufar eicosanoid production in normotensive and spontaneously hypertensive rats. Wetxef MCI, Li J, Afvarez RA, Anderson RE, Obrien PJ// Univ Kansas, Med Ctr, Dept Anat & Cell Biol, 39th & Rainbow Bfvd, Kansas City, Ks 66103, USA EXP EYE RES 1991,53 (4) 437 Metabolism of finoleic acid and docosahexaenoic acid in rat retinas and rod outer segments. Henberg GR// Mem Univ Newfoundland, Dept Biochem, St Johns, Newfoundland, Canada AlB 3X9 CAN MED ASSN J 1991,145 (7) 821 Fiih oils in the treatment of hypertrigfyceridemia. Lehr HA, Hubner C, Fin& B, Nofte D, BeiSiegel U, Kohfschutter A, Messmer K/I Univ Munich, Inst Surg Res, Marchioninistr 15, W8000 Munich 70, FRG CIRCULATION 1991,&Q(4) 1725 Dietary fish oil reduces feukocytelendothefium interaction following systemic administration of oxidativefy modified low density fipoprotein.

9. PLATELET-ACTIVATING FACTOR Adam K, Oswald I// The Birches, 41 St Ronans Terrace, Innerfeithen EH44 6RB, England L4NCE-I. 1991,338 (8775) 1157 Possible mechanism for adverse reactions to triaxoiam (Letter) Anfossi G, Mufaroni E, Trovati M, Massucco P, Cavafot F, Mattielfo L, Emanueffi G// Dept Cfin and Biof Sci, Univ Torino, Ospedale S Luigi Gonxaga, Regione Gonxofe 10, I10043 Orbassano, Torino, Italy ;I&LEIS (EDINBURGH) 1991,2 (3) A platelet defect character&d by absent adrenaline-induced aggregation and lack of secondary aggregation in response to ADP and platelet-activating factor. Tomeo AC, Egan RW, Duran WN// Univ Med B Dent New Jemev. New Jemev Med Sch, Dept Pftysiof, Div I&rocircufa~ory Res, Newark NJ 07103, USA FASEB J 1991,5 (13) 2850 Priming interactions between platelet activating factor and histamine in the in viva microcirculation. Afving K, Matran R, Lundberg JM// Karofinsfca Inst, Dept Pftarmacof, Box 60400, S-

10401 Stockholm 60, Sweden BRITJPHARMA COL 1991,104 (2) 452 Effect of nedocromif sodium on affetgen-induced, PAP-induced, histamine-induced and bradykinin-induced airways vasodifatation and pulmonary obstruction in the pig Meiiftyants AG, Kufikov VI// Minist Pubi Hfth USSR, Med Biotech Sci Ind Ctr, Inst Cell Biochem & Physiol, Moscow, USSR KHIM-FARM ZH SSSR 1991,25 (6) 10 Structural analogs of platelet-activating factor - correlation analysis of biological activity (Russian) Orfov SM, Vfasov AA, Savcfeva VF, Lfpatfdna LY, Kufikov VI// Minist Pubf Hfth USSR Inst Immunol, Mosow, USSR BULL EXP BIOL MED-ENGL TR 1991, 111 (4) 501 Effect of phosphofipid platelet activation factor on proliferation of peripheral blood fymphocytesB of normal individuals and bronchial asthmatics. Jancar S, Sirois MG, Carrier J, Braquet P, Sirois P// Univ Sao Paufo, Dept Imunof, Sao Pauio, Brazil INFLAMMATION 1991,15 (5) 347 PAF induces rat plasma extravasation and releases eicosanoids during anaphyfaxis.

Platelet response to the aggregatory effect of platelet activating factor (PAP) ex viva in pa tients with acute myocanfiaf infarction. Hellstrom WJG, Wang R, Sifdta SC// TuIane Univ, !kh Med, Dcpt &of, 1430 Tulane An, New Orfeans. La 70112. USA FERT SI’EtiL 1991,56 (4) 766 Platelet-activating factor stimulates motion parameters of cryopresemd human prm. Hopp RJ, Townfey RG, Agrawaf DK, Bewtra AK// Creighton Unfv, Ctr AIlerg Dis, Omaha, Ne 66178, USA CHEST 1991, loo (4) 994 Tetfenadine effect on the bronchoconstriction, dermaf response, and feukopenia induced by platelet-activating factor.

11. RELATED ENZYMES Piomefli D, Greengard P/l Unite de Neurobiofogie & Pharmacofogie, INSERM, U 109, Centre Paul Bmca, 2ter rue d’Afesia, Paris 75014, France PROC NAT ACAD SCI USA 1991,88 (15) 67706774 Bidirectional control of phosphofipase A2 activity by Ca2 + cafmodufindependent protein fcinase II, cAMPdependent protein fcinase, and casein fcinase II.

Karasawa K et al TANPAKUSHITSU KAKUSAN KOSO 1991,36 (3) 516-23 Production and apppfication of antibodies to PAF (Jpn)

Ghomashchi F, Yu BZ, Mihefich ED, Jain MK’. Gefb MH// lUniv Delaware. Dent C&em & B&hem, Newark, De 19716, USA BIOCHEMISTRY-USA 1991,30 (40) 9559 Kinetic characterization of phosphofipaseA2 modified by manoafogue.

Safcaguchi K, Morimoto S, Cften YH, Nakamoto Y, Ogihara T// Osafta Univ, Sch Med, Dept Geriatr Med, Fukushima ku, Osaka 553, Japan NEPHRON 1991,59 (3) 45.5 Increases in circulating level of pfateiet-activating factor fag behind transient neutropenia during hemodiafysis with cuprophane membranes.

Green JA, Smith GM, Buchta R, Lee R, Ho KY, Rajkovic IA, Scott KF// Pacific Biotechnof Ltd, 74 McLachfan Ave, Rushcutters Bay, NSW 2011, Australia INFLAMMATION 1991.15 151355 Circulating phospholipas&~ t&i& associated with sepsis and septic shock is indistinguishable from that associated with rheumatoid arthritis.

Gfaser KB, Lock YW, Cfrang N//Wyeth Ayemt Res, Div Immunopharmacof, CN ffOO0,Princeton, NJ 08543, USA AGENT ACTION 1991,34 (l-2) 89 PAF and LTB4 biosvnthesis in the human neutrophif - effects of putative inhibitors of phospholipase A2 and specific inhibitors of 5iipoxygenase.

Tsujimoto M et al TANPAlCUSHITSU KAKUSAN KOSO 1991, 36 (3) 643-9 Activation of phosphofipase A2 by cytofdnes

Will PC, Thomas TK, Ivemon L, Buckman D, Weis W, Wilson C, Srhastava A// Hoffmann La Roche Inc, Dept Pharmacof, Bldg 761036,340 Kingsland St, Nutfey, NJ 07110, USA AGENT ACTION 1991,34 (l-2) 181 Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat. Coeffier E, Joseph D, Vargaftig BB// Inst Pasteur, INSERM, U285, Unite Pharmacof Ceffufaire, 25 Rue Dr Roux, F-75724 Paris 15, France J IMMUNOL 1991,147 (8) 2595 Activation of guinea pig eosinophifs by human recombinant IL-5 - selective priming to platelet-activating factor-acether and interference of its antagonists. Tsefepis AD, Tsoukatos D, Droudes C, Donas A, Evangefou A// Univ Ioannina, Fat Med, Dept Cftem, Biochem Lab, GR-45110 Ioannina, Greece EUR J CLIN INVEST 1991,21(5) 490

B13

(JW

Gudgeon AM, Pate1 G, Hermontayfor J, Hurfey P, Bowyer RC, Jehanfi AMT.// *St George Hasp, Sch Med, Dept Surg, Cranmer Terrace, London SW17 ORE, England ANN CLIN BIOCHEM 1991,28 (Part 5) 497 Detection of human pancreatic pro-phosphofipaseA2 activation using an immunoassay for the free activation peptide DSGISPR Tranbarger TJ, Pranceschi VI& Hifdebrand DF, Grimes HD*// *Washington State Univ, Deut Bot. Pullman. Wa 99164. USA Pti CELL 1991,3 (9) 973 The soybean W-kilodalton vegetative storage protein is a fipoxygenase that is focalized in paraveinaf mesophyff cell vacuoles. Furstenberger G, Hagedom H, Jacobi T, Besemfelder E, Stephan M, Lehmann WD, Marfts F// Dept Biochem, German Cancer Res Ctr, W-6900 Heidelberg, FRG J BIOL CHEM 1991,266 (24) 15738 Characterization of an S-fipoxygenase activity induced 9 the phorbof ester tumor promoter 12.0-tetradecanoyfphorbof-13-acetate in mouse sftin in vivu.

Schetikelaars EJ, Singh HN, Goldberg RI+ Doughty JR, Peppard J, Dipaquak G, Quagliata F// Ciba Geigr Carp, Div Pharmaceut, 556 Morris Ave, Summit, NJ 07901, USA AGENT ACTION 1991,34 (l-2) 66 Pharmacologkal modulation ofrat monocytes - in viva effects on la expression and interleukin-1 production. Devriea GW, Lee G, Amdahl L, Wenzel M, Garst M, Wheekr WI Allergan Pharmaceut Inc, Dept Biol Sci, 2.525Dupont Dr, Irvine, Ca 92715, USA AGENT ACTION 1991,34 (l-2) 70 AGN 190383, a novel phospholipase inhibitor with topical anti-inflammatory activity. Wolyniec WW, Laplante AM, Kontny M, Laser ES, Letts LG, Wegner CD/f Eloehringer Ingelheim Pharmaceut Inc, Ridgefield, Ct 06877, USA AGENT ACTION 1991,34 (l-2) 73 31-L-239, a S-lipoxygenase inhibitor, blocks inhaled antigen-induced airway hyperresponsiveness in conscious guinea pigs. Hope WC, Pate1 BJ, Bolin DR// Hoffmann La Roche Inc, Dept AIkrgy & Inflammat Res, Nutley, NJ OnlO, USA AGENT ACIION 1991,34 (l-2) 77 Antiflammin-2 (HDMNKVLDL) does not inhibit phospholipase A2 activities. Berkenkopf JW, Marinati LR, Weichman BM* I/ l Wyeth Ayemt Rea, Div Immunopharmacol, Princeton, NJ 08343, USA AGENT ACIION 1991, 34 (l-2) 93 Phospholipase A2 acyl-hydrolytic activity in rat RPAR-induced pleurisy. Marinari LR, Berkenkopf JW, Weichman BM* // *Wyeth Ayemt Res, Princeton, NJ 08.543,USA AGENT ACTION 1991,34 (l-2) 97 Characterization of phospholipase A2 activity in rat RPAR-induced pleurisy. Panetta JA, Benslay DN, Shadle JK, Towner RD, Ho PPK// Eli Lilly & Co, Lilly Res Lab, Lilly Corp Ctr, Indianapolis, In 46285, USA AGENT ACTION 1991,34 (l-2) 100 Anti-inflammatory effects of LY221068 and LY269415. Winkler JD, Sung CM, Huang IJ/ Smithkline Beecham Pharmaceut, Dept Pharmacol, POB 1539, King of Prussia, Pa 19406, USA AGENT ACTION 1991,34 (l-2) 103 CoA-independent transacylase has characteristics distinct from those of PLA2 enzymes. Marshall IA, Bologncse B, Yuan W, Gelb M // Smithkline Beecham Pharmaceut, Dept Pharmacol, I-532, POB 1539, King of Prussia, Pa 19406, USA AGENT ACTION 1991,34 (l-2) 106 Phosphonate-phoapholipid analogues inhibit human phospholipase A2. Mcmillan RM, Bird TGC, Crawiey GC, Edwards MP, Girodcau JM, Kingston JF, Foster SJ// ICI Pharmaceut PLC, Res Dept I, Alderlev Pk. Macclesfield SK1 4TG, Cheshire. EnglAnd ’ AGENT ACTION 1991.34 (l-2) 110 Methoxyalkyl thiaxoks -‘a novel’series of potent, orally active and enantioselective inhibitom of S-lipoxygenase. Goodman R, Stevens TM, Mantegna LR, Kidd PR, Harris RR, Kerr J!I// Dupont Merck Pharmaceut Co, Wilmington, De

19898, USA AGENT ACTION 1991,34 (l-2) 113 Phoephoiijwe A2 (PLA2) activity in bovine pulmonary artery endothelial cells. Sirois P, Borgeat P, Law&m M, Dube L,

Rubm P. Kestemon J// Univ Sherbmoke. Fat Med, D&t Phannacol, Sherbrooke, Quebec, Canada JlH SN4 AGENT ACTION 1991,34 (l-2) 117 Effect of zileuton (A&077) on the S-lipoxygenase activity of human whole blood ex vtvo. Proudman KE, Mcmillan RM*// *ICI Pharmaceut PLC, Dept Elii 1, Alderley Pk, Macclesfleld SK10 4TG, Cheshire, England AGENT ACTION 1991,34 (l-2) 121 Are tolfenamic acid and tenidap dual inhibitom of S-lipoxygenase and ryclo-oxygenase. Kimble E, Koumlski T, White D, Rayehauduri A. Pastor G. Chertock H. Lee W. Neale R Hamdan A, W&ley J// Ciba Geigy &up, Dcpt Res, Div Phannaceut, 556 Morris Ave, Summit, NJ 07901, USA AGENT ACTION 1991,34 (l-2) 125 CGS 22745 - a selective orally active inhibitor of S-lipoxygenase. Imai A, Khan AA, Tamaya T/1 Gifu Univ, Sch Med, Dept Obstet & Gynecol, Tsukasamachi 40, Gifu 500, Japan ARCH GYNECOL OB!?I-ET 1991,249 (3) 129 Sex steroids enhance endotoxin-stimulated phospholipaseA2 activity in hum endometrial cells.

12. PRODUCTION AND RELEASE Hayakawa M, Oku N, Takagi T, Hori T, Shibamoto S, Yamanaka Y, Takeuchi K, Tsujimoto M, Ito F// Setsunan Univ, Fat Pharmaceut Sri, Dept B&hem, Hirakata, Osaka 57301, Japan CELL STRUCT FUNCT 1991,16 (4) 333 Involvement of prostaglandin-producing pathway m the cytotoxic action of tumor necrosis factor. Krieger J, Benxoni D, Sfotza E, Sassard J// Clin Neurol, F-67091 Stmsbourg, France CLIN EXP PHARMACOL PHYSIOL 1991, 18 (8) 551 Urinay excretion of prostanoids during sleep in obstructive sleep apnoea patients. Rigotti P, Amodio P, Sacerdoti D, Ferraesso M, Bomato M, Morpurgo E, Menon F, AngeIi P// Ist Semeiot Chirurg Oot, Via Facciolati 71, I-35127 Padua, Italy NEPHRON 1991,59 (3) 477 Effects of detibrotide on renal function and urinary pmstanoid excretion in ciclosporintreated rats. Bunke M, Wilder L, Martin AI/ Univ Louisville, Dept Med, Div Nephrol, Louisville, Ky 40292, USA TRANSPLANTATION 1991,52 (4) 718 The effect of qclosporine on agonist-stimulated glomerular and mesangial cell vasodilatory prostaglandin production. Hirawa N, Uehara Y’, Numabe A, Takada S, Matsuoka H, Ikeda T, Sugimoto T, Yagi S, Ishii M// lUniv Tokyo, Dept Internal Med 2, 7-3-l Hontto. Bunkvo ku, Tokyo 113, Janan CLIN SCI-1991,81-(4) 499 Stimulating effects of atenolol on vasodepressor prostaglandin generation in sponta-

B14

neously hypertensive rats. Stein TA, Keegan LM, Auguste W, Bailey B, Wii U/ Albert Einstein Coil Med. Long Isl Jewish Med Ctr, Dept Surg, Long Isl OimDUS. New Hvde Pk. m 11042. USA i SURG RI% 199i, 51(S) 368 Stress-induced gastric lesions and the bynthesis of prostaglandins and leukotriencs. bJ~~;VWJVLarina

IM, Zharkoskaya EE,

KOSM BIOL AVIAKOSM MED SSSR 1991,25 (5) 33 Variations in prostaglandins and lipid metabolism in men exposed to prolonged bed rest (Russian)

13. EFFECTS Ji I, Slaughter RG, Ellis JA, Ji TH, Murdoch WJ’// lUniv Wyoming, Dept Anim Sci, POB 3684, Laramie, Wy 8207I, USA MOL CELL ENDOCRINOL 1991,81 (l-3) 77 Analyses of ovine corpora lutea for tumor necrosis factor messenger RNA and bioactivity during prostaglandin-induced luteolysis.

14. PROSTAGLANDINS MEDICINE

IN

Davenport A, Will El, Davison AM// St James Univ Hosp. Dept Renal Med, Room 75 Renal Res, Cl&i Sci-Bldg, Beckett St, Leeds IS9 7TF. W Yorkshire. Ennland NEPHRON 1991,59 (3) 449 ” Adverse effects on cerebral perfusion of prostacyclin administered directly into patients with fulminant hepatic failure and acute renal failure. Sinzinger H, Rogatti W// Wilhelm Auemwald Atherceklroseforsch Grp Wien, Nadlergasse 1, A-1090 Vienna, Austria WIEN KLIN WOCHENSCHR 1991,103 (18) 558 Prostaglandin-El in the therapy of peripheral arterial occlusive disease (German) Abe K, Demizu A, Kamada K, Morimoto T, Sakaki T, Yoshii I// Osaka Police Hasp, Dept Anaesthesiol, 1031 Kitayamacho, Tennouji ku, Osaka 543, Japan CAN J ANAESTH 1991,38 (7) 831 Local cerebral blood flowwith prostaglandinEl or trimethaphan during cerebral aneurysm clip ligation.

15. PROSTAGLANDINS AS DRUGS Gill J, Dandona P, Jeremy JY’N *Metabolic Unit, Dept Chem Pathol Human Metabolism, Royal Free Hasp & !Ich Med, Pond Street, London NW3 2QG, England F3,AAI’ELEIS (EDINBURGH) 1991,2 (2) Atypical beta- and alpha2adrenoceptor activation, dibutyql CAMP and ilopmst stimulate (45Ca2 + ] uptake by human platelets. Norman JE, Thong KJ, Baird DT*// lCtr Reprod Biol, Dept Obstet & Gynaecol, Univ Edinburgh, 37 Chalmers St, Edinburgh EH3 9EY, Scotland LANCET 1991,338 (8777) 1233 Uterine contactility and induction of abortion in early pregnancy by misoprostol and mifepristone. LANCET 1991,338 (8777) 1241 Misoprostol and legal medical abortion

Widomski DL, Walsh RE, Baron DA, Hi&ei MI. Fretland DJ, Collins PW, Gaginella ?‘%*/j*Seatie Rea & Dev, Gast&nt&inal Dis Res & Pathol. Skokie. II 60077. USA AGENT ACTION 199l,j4 (l-2) 30 Effects of the prostagiandin analogue misop rostol on inflammatory mediator release by human monocytes. Miller MJS, Zhang XJ, Gu X, Sadowskakmwicka H, Clark DA// Louisiana State Univ, Med Ctr. Sch Med. Deot Pediat. 1542 Tulane Ave, Ne& Orleans,’ La ?0112, USA AGENT ACTION 1991,34 (l-2) 185 Miirostol attenuates acetic acid-induced damage in rabbit distal small intestine. Rutgeerts P, Vantrappen G, Hielc M, Ghoos Y, Onkelinx c// Univ Hosp Leuven, Dept Med Res, Louvain, Belgium ALIMENT PHARMA COL THERAPEUT 1991,s (5) 533 Effects on bowel motility of misoprostol administered before and after meals. Rimoldi 0, Pierini S, Pagani MR, Pagani M// CNR, Ctr Ricerche Cardiovasc, Ist Ricerche Cardiovasc, Via Bonfadini 214, I-20138 Milan, Italy CARDIOVASC RES 1991,25 (10) 793 Reduced cardiovascular sympathetic excita-

tory responses during iloprost infusion in conscious dogs.

kotriene.

16. INHIBITORS OF SYNTHESIS

Third International Congress on Fatty Acids and Eicosanoids. lst-5th March 1992. ‘Ihe Adelaide Convention Centre, Adelaide, South Australia. Abstract Deadline: 3rd December 1991. For details concerning submission of abstracts, registration, student travel grants and accommodation contact: Jenny Blanchard, EFA 1992 Congress Office, PO Box 153, Naime, South Australia 5252. Phone and Fax: (61-8) 3&I 6164

Roland DM, Macchia WM, Grim KS, Rimble EF, White DH, RowaIski TJ// Ciba Geigy Corp, Dept Res, Div Pharmaceut, 556 Morris Ave, Summit, NJ 07901, USA AGENT ACTION 1991,34 (l-2) 145 Leukotriene biosynthesis inhibition by aryI and aroyI substituted naphthoquinones.

18. CHEMICAL SYNTHESIS Cotterill XC,Jaouhari R Dorman G, Roberts SM, Scheinmann F, Wakefield BJ// Univ Exeter, Dept Chem, Exeter EX4 4RJ, Devon, England g?M SOC PERICIN TRANS I 1991(10) Use of the 2 enantiometem of 7,7dimethyIbicyclo[3.2.O]Hept-2cn6-o ne to form complementary optically active synthons in a convergent synthesis of leukotrieneB4. Babudri F2, Fiandaneae V, Naso F*// lUniv Bari, Dipartimento Chim, CNR, Ctr Studio Metodol Innovat Sin&i Organ, Via Amendola 173, I-70126 Bari, ItaIy J ORG CHEM 1991,56 (21) 6245 Conjugated poIyene synthesis via disilyi derivatives - A direct access to ostopanic acid, a plant anticancer agent and to (6E)-LTB3 leu-

B15

20. FORTHCOMING

EVENTS

Meeting Announcement. The Dept of Nutrition, Univ North Carolina at Chapel Hills is sponsoring a conference on: Choline Phospholipids: Molecular Mechanisms for Human Diseases, April 3-4,1992, Hotel del Coronado, San Diego, Ca, USA. Topics include: Cardiovascular Disease and Platelet Activating Factor. Attendance will be by invitation only. Meeting will be limited by 100 attendees. Some travel gtanta will be available. Send an NIHstyle curriculum vitae (or, for doctoral students, a letter from your advisor) to: Steven H Zeiil, MD, PhD, Dept Nutr, Univ North Carolina, Chapel Hill, NC 27599.7400. Fax 919 966-7216.

‘IWICE MONTHLY BIBLIOGRAPHY ON PROSTAGWDINS BIOLOGY- LATE DECEMBER PREPARED BY SHEFFIELD UNIYERSI’IY BIOMEDICAL INFORMATION SERVICE SHEFFIELD SlO 2TN 1. BOOKS, REVIEWS, SYMPOSIA Silvia WJ, L&is GS, Mccracken JA, Thatcher WW. Wilson IJ/ Univ Kentucky, Dept Anim .!&, Lexington, Ky 40546, U&i BIOL REPROD 1991,45 (5) 655 Review - hormonal regulation of uterine secrrtion of prostaglandin-F2alpha during luteolysis in ruminants. Chapleau MW, Hajduczok G, Abboud FM// Univ Iowa, Colt Med, Dept Internal Med, Iowa City, Ia 52242, USA CLINEXPHYPERTENSA-THEOR 1991, 13 (S) 817 Paracrine role of pmstanoids in activation of arterial baroreceptors - an overview.

2. GENERAL Ohia SE, Jumblatt JE*// lUniv Louisville, Sch Med, Long Eye Res Inst, Dept Ophthalmol & Visual Sci. Louisville. Kv 40292. USA CURR EYE& 1991,lO (lOj%7 Prejunctional prostaglandin receptors in the human iris-cilialy body. Brown JA, Gray CI, Hattersley G, Robinson J// Univ Exeter, Hatherly Labs, Dept Biol Studies, Exeter EX4 4PS, England GEN COMP ENDOCRINOL 1991,84 (2) 328 Prostaglandins in the kidney, urinary bladder and gills of the rainbow trout and European eel adapted to fresh water and seawater.

PRECURSORS 4. Arachidonic Acid Chik CL, Young I, Ho AK// Heritage Med Res Ctr, Room 362, Clin Wing, Edmonton, Alberta, Canada T6G 2S2 J NEUROCHEM 1991,57 (5) 1534 Differential involvement of the arachidonic acid cascade on the alpha-l-adrenergic potentiation of vasoactive intestinal peptideadrenergic-stimulated veTsus beta-adrenergicstimulated cyclic AMP and cyclic GMP accumulation in rat pinealocytes. Reichman M, Nen W, Hokin LE*// ‘Univ Wisconsin, Sch Med, Dept Pharmacol, 1300 Univ Ave, Madison, Wi 53706, USA MOL PHARMACOL 1991,40 (4) 547 Delta9-tetrahydmcannabinol inhibits arachidonic acid acylation of phospholipids and triacylglycerols in guinea pig cerebral cortex slices. Clements MP, Bliss TVP, Lynch MA// Natl Inst Med Res, Div Neurophysiol & Neuropharmacol, Ridgeway, Mill Hill, London NW7 IAA, England NEUROSCIENCE 1991,45 (2) 379 Increase in arachidonic acid concentration in a postsynaptic membrane fraction following the induction of long-term potentiation in the dentate gyrus. Steinbeck MJ, Hegg GG, Kamovsky MJ// Dept Pathol, Harvard Med Sch, Bldg C-2 Rm 324,240 Longwood Ave, Boston, Ma 02115, USA J BIOL CHEM 1991,266 (3) 16336.16342 Arachidonate activation of the neutrophil NADPH-oxidase. Synergistic effect of protein phosphatase inhibitors compared with protein kinase activators.

Reid T, Ramesha CS, Ringold GM*// lInst Cant & Develop Biol, Syntex Res, 3401 Hillview Ave, Palo Alto, Ca 94304, USA J BIOL CHEM 1991,266 (25) 16580-16586 Resistance to killing by tumor necrosis factor in an adipocyte cell line caused by a defect in arachidonic acid biosynthesis. Pasechnikov VD// Stavropol Med Inst, Dept Internal Dis 1, Stavropol, USSR KLINICH MED 1991,69 (9) 69 Synthesis of lipoxygenase metabolites of arachidonic acid and their role in pathogenesis of gastric mucosa inflammation (Russian) Bajpai P, Bajpai P& Ward OP*// lUniv Waterloo, Dept Biol, Waterloo, Ontario, Canada N2L 3Gl J AMER OIL CHEM SOC 1991,68 (10) 775 Effects of aging Mortierella mycelium on pmduction of arachidonic and eicosapentaenoic acids. Kaleta EW, Applegate LA, Ley RD’N *Lovelace Fdn Med-E!duc & Res, Ct; Photomed, 2425 Ridecrest Dr SE. Albuauemue. NM 87108, USA - PHOTOCHEM PHOTOBIOL 1991,54 (5) 747 Photoreactivation of ultraviolet radiation-induced release of arachidonic acid from marsupial cells. Rozengurt E// Imperial Cant Res Fund, POB 123,44 Lincolns Inn Fields, London WC2A 3PX,England CANCER CELL-MON REV 1991,3 (10) 397 A role for arachidonic acid and its metabolites in the regulation of p2lras activity. Nangalama AW, Moberg GP*// lUniv Calif Davis, Dept Anim Sci, Davis, Ca 95616, USA J ENDOCRINOL 1991,131(l) 87 Interaction between cortisol and arachidonic acid on the secretion of LH from ovine pituitaIy tissue. 5. PROSTAGLANDINS E AND F Hamilton JA, Piccoli DS, Leizer T, Butler DM, Croatto M, Royston AKMN Dept Med, Univ Melbourne, Royal Melbourne Hasp, Parkville, Vie 3050, Australia PROC NAT ACAD SCI USA 1991,88 (16) 7180-7184 Transforming growth factor beta stimulates urokinase-type plasminogen activator and DNA synthesis, but not prostaglandin F2 production, in human synovial fibroblasts. Chan SY// Univ Hong Kong, Dept ZOOI, Pokfulam Rd, Hong Kong, Hong Kong PROSTAGLANDINS 1991,42 (4) 321 Effects of prostaglandin E2 and F-2alpha on peri-implantation development of mouse embryos in vitro. Hawkes JS, James MJ, Cleland LG// Royal Adelaide Hasp, Rheumatol Unit, Adelaide, SA 5000, Australia PROSTAGLANDINS 1991,42 (4) 3.55 Separation and quantification of PGE3 following derivatization with panacyl bromide by high pressure liquid chromatography with fluommetric detection.

Loyola Hines Dept Radiotherapy, 114B, Hines, II 60141, USA RADIAT RE!S 1991,128 (1 Suppl) S12 Misoprostol, a PGEl analog, protects mice from fission-neutron injury. Melnik B, Plewig G, Tschung T// Eickhoffstr 20. W4830 Gutersloh 1. FRG

ALLERGY 1991,46(7j502 Are deficiencies of prostaglandin-E-mediated immunoregulation involved in increased IgB synthesis of atopic mononuclear cells in vitro. Schalkwijk C, Velvoordeldonk M, Pfeilschifter J, Marki F, Vandenbosch H // Ctr Biomembranes & Lipid Enzymol, Padualaan 8, 3584 CH Utrecht, Netherlands BIOCHEM BIOPHYS RES COMMUN 1991,180 (1) 46 Cytokine-induced and forskolin-induced synthesis of group-II phospholipase-A2 and prostaglandinZ2 in rat mesangial cells is prevented by dexamethasone. Iwayama T, Leung PSC, Coppel RL, Roche TE, Pate1 MS, Mizushima Y, Nakagawa T, Dickson R, Gershwin ME*// lUniv Calif Davis, Sch Med, Div Rheumatol Allergy & Clin Immunol, TB 192, Davis, Ca 95616, USA J AUTOIMMUN 1991,4 (5) 769 Specific reactivity of recombinant human PDC-Elalpha in primary biliary cirrhosis. Archbald LF, Norman SN, Tran T, Lyle S, Thomas PGA// Univ Florida, Coil Vet Med, Deot Lame Anim Clin Sci. Gainesville. Fl 32810, USA VET MED-US 1991,86 (10) 1037 Does GnRH work as well as GnRH and PGF2alpha in the treatment of ovarian follicular cysts. Huo TH, Healy DP*// *CUNY Mt Sinai Sch Med. Dept Pharmacol, Box 1215,l Gustave Levy PI, hew York, N? 10029, GSA AMER J PHYSIOL 1991.261(4) P2. F647 PmstaglandinZ2 production in‘kt IMCD cells. 1. Stimulation by dopamine. Huo TL, Grenader A, Blandina P, Healy DP*// *CUNY Mt Sinai Sch Med, Dept Pharmacol, Box 12151 Gustave Levy PI, New York, NY 10029, USA AMER J PHYSIOL 1991,261(4) P2, F65S ProstaglandinZ2 production in rat IMCD cells. 2. Possible rule for locally formed dopamine. Osuga Y, Mitsuhashi N, Mizuno M// Univ Tokyo, Fat Med, Dept Obstet & Gynecol. 73-l &ngo, Bunkyo l&, Tokyo 113, japan ENDOCRINOL JPN 1991.38 (31339 Endothelin-1 and endothelin3‘s~mulate pmstaglandin-E.2 secretion from the rat median eminence. Laifer SA, Ghodgaonkar R, Caritis SN, Dubin NH// Magee Womens Hasp, Forbes Ave & Halket St, Pittsburgh, Pa 15213, USA OBmGYNECOL 1991,78(5)Pt1,753 Changes in uterine venous prostaglandin-F metabolites following intravenous infusion of ritodrine in sheep.

6. PROSTACYCLIN Hanson WR, Grdina DJ// Loyola Univ,

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Plotkin VY, Rebrov BA// Voroshilovgrad

Med Inst, Dept Postgrad Med Training,

Chair Therapy, Vorosilovgrad, Ukraine, USSR LAB DEL0 1991, (8) 27 Aldosterone, thromboxaneA2, and prostacyclin measurements in biologic fluids (Russian) Levine L, Watanabe M// Brandeis Univ, Dept B&hem, Waltham, Ma 02254, USA PROSTAGLANDINS 1991,42 (4) 291 Amplification of prostaglandin 1-2 production by thapsigargin. Jasehonek K, Clemens MR, Scheurlen M/l Univ Tubingen, Med Klin & Poliklin, Ottfried Muller Str, W-7400 Tubingen 1, FRG THROMB RES 1991,63 (6) 667 Decreased responsiveness of platelets to a stable prostacyclin analogue in patients with Crohn’s disease - Reversal by N-3 polyunsaturated fatty acids. Eltahir KEH, Alkharji AMH, Ageel AM// King Saud Univ, Coil Pharm, Dept Pharmacol, POB 2457, Riyadh 11451, Saudi Arabia GEN PHARMACOL 1991,22 (5) 837 Influence of diethylcarbamazine and mefloquine on PG12 synthesis by the rat thoracic aorta and myometrial tissues. Zhou 0, Zhao Y, Li P, Bai X, Ruan C’// ‘Suzhou Med Coil, Jiangsu Inst Hematol, Thrombosis & Hemostasis Res Unit, Suzhou 215007, Peoples R China NOUV REV FR HEMATOL 1991,33 (4) 281 A monoclonal antibody (SZ-53) against thrombomodulin inhibits thrombin-mediated release of t-PA and PG12 from endothelial cells.

7. THROMBOXANES Janssen LJ, Daniel EE*// lMcMaster Univ, Dept Biomed Sci, Div Pharmacol & Physiol, 1200 Main St W, Hamilton, Ontario, Canada L8N 325 AMER J PHYSIOL 1991,261 (4) Pt 1, L271 Prejunctional and postjunctional effects of a thromboxane mimetic in canine bronchi. Atzori L, Olafsdottir K, Corriga AM, Bannenberg G, Ryrfeldt A, Moldeus P*// lKarolinska Inst. Inst Environm Med. Deut Toxicol, Box 6&O, S-10401 Stockholm 60, Sweden J APPL PHYSIOL 1991,71(4) 1309 Thiol modification in H202-induced and thromboxane-induced vasoconstriction and btonchoconstriction in rat perfused lung. Fujioka K, Sugi K, Isago T, Flynn JT, Traber LD, Hemdon DN, Traber DL’// lUniv Texas, Med Branch, Dept Anesthesiol Physi01& Biophys, 610 Texas Ave, Galveston, TX 77550, USA J APPL PHYSIOL 1991,71 (4) 1376 Thromboxane synthase inhibition and cardiopulmonary function during endotoxemia in sheep.

Wojenski CM, Schick PK// Cardeza Fdn, 1015 Walnut St, Philadelphia, Pa 19107, USA J LAB CLIN MED 1991,118 (4) 370 Differences in thromboxaneA2 synthesis by megakaryoqtes and platelets. Fujimura M, Bando T, Miiuhashi K, Matsuda T// Kanazawa Univ, Sch Med, Dept Internal Med 3,13-l Takara Machi. Kanazawa. lshikawa 920, Japan

PROSTAGLANDINS 1991,42 (4) 379 Interaction of thromboxane& and leukotrienes in guinea pig airways in vivo. Fujimura M, Ogawa H, Saito M, Sakamoto S, Miyake Y, Matsuda T// Kanazawa Univ, Sch Med, Dept Internal Med 3,13-l Takara Machi, Kanazawa, Ishikawa 920, Japan ALLERGY 1991,46 (7) 534 Inhibitory effect of inhalation of a thromboxane synthetase inhibitor on bronchoconstriction induced by aerosolized leukotriene-C4 and thromboxaneA2 analogue in anesthetized guinea pigs. Jones DA, Fitzpatrick FA, Malcolm KC// Univ Colorado, Hlth sci Ctr, Dept Pharmacol, Denver, Co 88262, USA BIOCHEM BIOPHYS RES COMMUN 1991,180 (1) 8 ThromboxaneA2 synthesis in human etythroleukemia cells. Dom GW// Univ Cincinnati, Coil Med, Dept Med Cardiol. Cincinnati. Oh 45221. USA J PHARMACOL ExP~-HERi99i,259 (I) 228 Mechanism for homologous downregulation of thromboxaneA2 receptors in cultured human chronic myelogenous leukemia (KS62) cells. Stroh S, Elmadfa I*// lUniv Wien, Inst Ernahrungwissensch, Lammgasse 8, A-1089 Vienna, Austria Z ERNAHRUNGSWISS 1991,30 (3) 192 In vitro estimation of the influence of different mixtures of omega3-fatty omega&fatty acids on the platelet aggregation and thromboxane synthesis in human platelets (German) Mckenniff MG, Norman P*, Cuthbert NJ, Gardiner PJN *Bayer UK Ltd, Pharma Res, Stoke Poges SL2 4LY, England BRIT J PHARMACOL 1991.104 (3158.5 BAY-~3405, a potent and selective’thromboxane-A2 receptor antagonist on airway smooth muscle in vitro. Norel X, Labat C. Gardiner PJ, Brink C* // *Ctr Chirurg Marie Lannelongue, CNRS, URA 1159.133 Av Resistance. F-92350 Le Plessis Robins, France BRIT J PHARMACOL 1991,104 (3) 591 Inhibitory effects of BAY-u3405 on prostanoid-induced contractions in human isolated bronchial and pulmonary arterial muscle preparations. Francis HP, Greenham SJ, Pate1 UP, Thompson AM, Gardiner PJ// Bayer UK Ltd, Pharma Res, Stoke Poges SL2 4LY, England BRIT J PHARMACOL 1991,104 (3) 596 BAY-u3405 an antagonist of thromboxaneA2-induced and prostaglandin-D2-induced bronchoconstriction in the guinea-pig. Anfossi G, Massucco P, Mularoni E, Cavalot F, Burzacca S, Mattiello L, Trovati M// Univ Turin, Osped S Luigi Gonzaga, Dept Clin & Biol Sci, Turin, Italy GEN PHARMACOL 1991,22 (5) 773 Phenothiazines inhibit collagen-induced thromboxane-B2 synthesis and increase forskolin anti-aggregating effects in human platelets. Watanabe T, Yatomi Y, Sunaga S, Miki I, Ishii A, Nakao A, Higashihara M, Seyama Y, Ogura M, Saito H et al// Univ Tokyo, Fat Med, Dept Internal Med 1, 7-3-l Hongo,

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Bunkyo ku, Tokyo 113, Japan BLOOD 1991,78 (9) 2328 Characterization of pmataglandin and thromboxane receptors expressed on a megakatyoblastic leukemia cell line, MEG-Ols.

8. LEUKOTRIENES Lagarde M// Inst Natl Sci Appl, INSERM, U205, BAT 406, F-69621 Villeutbanne, France REV FR ALLER IMMUNOL CLIN 1991, 31 (3) 167 Eicosanoids and intercellular connections involving blood and vessels (French) Tulleken JE, Limburg PC, Muskiet FAJ, Kazemier KM, Boomgaardt IK, Vanrijswijk MH// State Univ Gro&tgen Hasp, Dept Rheumatol. Oostersineel59. POB 3OOlJl. 9700 RB Groningen,
alummtMakul s,witzba BJ, Murphy GK, Kirdeikis KL, Keekn M, ckndii m, Thomson ABIt*// *u?biv Alter& Dept Me4 Div Glltmcntc#i, 519 RdlcIt NawtonRUT

Bldg, Edmotttoa, Alberta, Canada T60 2c2 3LABCLINMED1991,118(4)363 The irradiation-asaocmted decline in the in viva uptake of glucose obaervcd in rats fed fLsh oil is prevented by feeding a diet enriched in saturated fatty acids. Narisawa T, Takahashi M, Kotanagi H, Kusaka H, Yamazaki Y, Koyama H, Fukaura Y, Nishizawa Y, Kotsugai M, Isoda Yet al// Akita Univ, COUAllied Med Sci, Sch Med, Dept Surg, Hondo l-l-l, Akita 010, Japan JPN J CANCER RES 1991,82 (10) loS9 Inhibitory effect of dietary perilla oil rich in the n-3 polyunsaturated fatty acid alpha-linolenic acid on colon carcinogenesis in rats. Carbon SE, Cooke RJ, Rhodes PG, Peepks JM, W&man SH, Tolley EA// Newborn Ctr, Room 201,853 Jefferson Ave, Memphis, Tn 38163, USA PEDIAT RES 1991,30 (5) 404 Long-term feeding of formulas high in linolenic acid and marine oil to very low birth weight infants - Phospholipid fatty acids. Nakamura M, Bakhle YS*// ‘Royal Coil Surg England, Hunterian Inst, Dept Pharmacol, Lincolns Inn Fields, London WC2A 3PN, England PROSTAGLANDINS 1991,42 (4) 303 Effects of Ph CL 28A on eicosanoid synthesis in rat isolated hearts. Maddox JF, Reddy CC, Eberhart RJ, Seholz RW// Mayo Clin & Mayo Grad Sch Med. Intemal M&l, Rochester,-Mn 55905, USA PROSTAGLANDINS 1991.42 (4) 369 Dietary selenium effects on milke&sanoid concentration in dairy cows during coliform mastitis. Wiegand RD, Koutr CA, Stinson AM, Andemon RI?& Baylor Colt Med, Cullen Eye Inst, 1 Baylor Plaza, Houston, TX 77030, USA J NEUROCHEM 1991,57 (S) 1690 Conservation of docosahexaenoic acid in rod outer segments of rat retina during n-3 and n6 fatty acid deficiency. Mialon P, Barthelemy I_.‘/Fat Med Brest, Phvsiol Lab. CNRS. UA 648.22 Av Camille D&moulini BP Bli, F-29285 Brest, France MOL CHEM NEUROPATHOL 1991,lS (I) 1 The influence of one hyperbaric oxygen-induced seizure on brain eicosanoid content. Nishimura M, Schwartzman ML’, Falck JR, Lumin S, Zirmlli JA, Murphy RC// *New York Med Coil, Dept Pharmaeol, Valhalla, NY 10595, USA EH BIOCHEM BIOPHYS 1991,290 (2) Metabolism of 12(R)-hydmxy-5,8,10,14cicosatetraenoi c acid (12(R)-HETE) in comeal tissues - formation of novel metabolites. Schwartzman ML, Omata K, Lin FM, Bhatt RK, Falck JR Abraham NG// New York Med Coil, Deot Phannacol, Valhalla, NY 10595, USA BIOCHEM BIOPHYS RES COMMUN 1991,180 (1) 445 Detection of 20-hydroxyeicosatetraenoic acid in rat urine. Davies EV, Campbell AK Hallett MB*//

lUniv Waks Coil Med, Dept Surg, Heath Pk, Cardiff CF4 4XN, S Glam, Wales FEBS LEFT 1991,291(l) 135 Synchronous free Ca2 + changea in individual neutrophils stimulated by leukotriene-W.

SAFRMEDJ1991,80(7)360 Fib oil suppkmentation and catdiovascukr

Charnock JS, Abeywardena MY, Tan D, Mclennan PI_&CSIRO. Div Human Nutr, Glenthome Labs, Ohailoran Hill, SA 5158, Australia NUTR RES 1991,11(9) 1013 Omega-3 and omega-6 pufa’s have different effects on the phospholipid fatty acid composition of rat myocardial muscle when added to a saturated fatty acid dietary supplement.

Immunol. F-91191 Glf Sur Yvette. Flnnce BIOCHIM BIOPHYS ACTA 1991,107S (2) 162 Development of enzyme immunoamays for kukotrienea using acetykholIneatcraae.

Chamcxk JS, Mclennan PL, Sundram K, Abevwardena MY// CSIRO. Div Human Nut;, Glenthome Labs, Ohalloran Hill, SA 5158, Australia NUTR RES 1991,11(9) 1025 Omega-3 pufa’s reduce the vulnerability of the rat heart to iachaemic arrhythmia in the presence of a high intake of saturated animal fat. Nordoy A// Univ Tromso, Inst Clin Med, Deot Med. N-9912 Tromso. Nonvav DRUGS 1991,42 (3) 331 Is there a rational use for n-3 fatty acids (fish oils) in clinical medicine (Leading Article) Ng CF, Sun FE, Taylor BM, Wolin MS, W>ng PYK*// *New York Med Coil, Dept Phvsiol. Valhalla. NY 10595. USA J ~M~JNOL 1591,147(9)'3096 Functional properties of guinea pig eosinophi1 leukotrieneB4 receptor. Filler SG, Ibe BO, Luckett PM, Raj JU, Edwards JE*// lUniv Cnlif Los Angeles, Los Aneeles Citv Harbor Med Ctr. Sch Med. Dept Internal Med, Div Infeci Dis, Torrance, Ca 90509, USA J INFEC DIS 1991,164 (5) 928 Candida albicans stimulates endothelial cell eicosanoid production. Lehr HA, Menger MD, Nolte D, Messmer K// Univ Munich, lnst Surg Res, Marehioninistr 15, W-8888 Munich 70, FRG TRANSPLANT PROC 1991,23 (5) 2356 Favorable effects of dietary fiih oil on capillary perfusion homogeneity after ischemia and reperfusion. Post S, Goerig M, Otto G, Manner M, Hofmann W// Univ Heidelberg, Chirurg Klin, Kirschnerstr 1, W-6900 Heidelberg,-FRG TRANSPLANT PROC 1991.23 15‘)2421 Early generalized activation of ei&noid synthesis after liver transplantation. Gordon EEI, Gordon JA, Spector AA// Univ Iowa, Co11Med, Dept Internal Med, Div Cardiovasc, E32.5GH, Iowa City, Ia 52242, USA AMER J PHYSIOL 1991,261(4) Pt 1, C.623 HFXEs and coronary artery endothelial cells metabolic and functional interactions. Oming L, Krivi G, Gierse J, Aykent S, Furpatrick FA// Dept Pharmacol, C236, Univ Coiorado Hlth Sci ‘ctr, Denver, Co 80262, USA J BIOL CHEM 1991.266 (2.5) 16507-16511 Inhibition of leukotri&e A4 ~ydrolase/aminopeptidase by captoprii. Booyens J, Vandermenve CF// Med Univ S Africa, Dept Internal Med, Div Gastroenterol, PO Medunsa 0204, Medunsa, South Africa

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disease. Antoine C, L.elloucbc JP, h4aclouf J, Pradelks P’N CENS, DRIPP, Senr pbvsufol C

l

Chapkin RS, Cable IU// Texas A&M Univ Cyst, Dept Anim Sci, Molec & Cell Biol Sect, College Stn, TX 77843, USA BIOCHN BIOPHYS ACTA 1991,1C%S(3) 365 Utilization of gammalinolenic acid by mouse peritoneal macrophages. Berger A, German JB*// lUniv California, Dept Food Sci, 223 Food Sci & Technol Bldg, Davis, Ca 95616, USA BIOCHIM BIOPHYS ACI’A 1991,108S (3) 371 Extensive incorporation of dietary DeltaS,11,14 eicosattienoate into the phosphatidylinositol pool. Kline WF, Han YHR, Matuszewski BK’, Bavne WF// *Merck Sham & Dohme Ltd. W Point, Pa 19486, USA * J PHARMACEUT BIOMED ANAL 1991,9 (6) 511 Determination of (3-[l-@-chlorobenzyl)-3tert-butvl-thi o-~-isoomovlindol-2-vll-2.2di methylpropanoic acid), a novel Ieukotriene biosynthesis inhibitor, in human plasma and urine by liquid chromatography. .I

I

I

Virella G, Fourspring K, Hyman B, HaskiUstroud R, bng L, Vinlla I, L.&a M, Gruts AJ, Lopesvirella M// Dept Microbial & Immunol, Charleston, SC 29425, USA CLIN IMMUNOL IMMUNOPATHOL 1991,61(2) Pt 1,161 Immunosuppressive effects of fsh oil in normal human volunteers - correlation with the in vitro effects of eicosapentaenoic acid on human lymphocytes. Garofalo R, Faden H*, Sharma S, Ogm PL // *SUNY Coil Buffalo, SEh Med, Dept Pediat, Buffalo, NY 14222, USA INFEC 1MMUNl’I-Y 1991,59 (11) 4221 Release of leukotriene-B4 from human neutrophils after interaction with nontypable Haemophilus influenzae. Katoh T, Takahashi K, Capdevila J, Karara A, Falck JR Jacobson HI& Badr m// *Vanderbilt Univ, Med Ctr, Dept Med, S-3223 Med Ctr N, Nashville, Tn 37232, USA AMER J PHYSIOL 1991.26lf4) P2. F578 Glomerular stereospecifi~sy&$i and _ hemodynamic actions of 8,9epoxyeicosatrienoic acid in rat kidney. Ahmadzadeh N, Shingu M, Nobunaga M, Tawara T// Kyushu Univ, Med Inst Bioregulat, Dept Internal Med, Fukuoka 812, Japan INFL4MMATION 1991, I.5 (6) 497 Relationship between leukotrieneB4 and immunological parameters in rheumatoid synovial fluids. Luostarinen R, Siegbahn A, Saldeen T*// lUniv Uppsala, Dept Forens Med, Dag Hammamkjolds Vag 17, S-75237 Uppsala, Sweden UPSAL J MED SCI 1991, % (2) 103 Effects of dietary supplementation with vitamin-E on human neutrophil chemotaxis and

generation of LTB4.

telet-activating factor receptor antagonist.

Strasser T, Schiffl H// Univ Munich, Klinikum Innenstadt, Med Klin, Ziemessenstr 1, W-8000 Munich 2, FRG KLIN WOCHENSCHR 1991,69 (17) 808 Generation of leukotrieneB4 by hemodialyxer membranes - A novel index of biocompatibility.

Agrawal DK, Bergren DR, Byorth PJ, TownIcy RG// Creighton Univ, Sch Med, Ctr Allerg Dis, Dept Internal Med, Omaha, Ne 68178, USA J PHARMACOL EXP THER 1991,259 (1) I Platelet-activating factor induces nonspecific desensitization to bronchodilators in guinea pigs

9. PLATELET-ACTIVATING FACTOR Melikyants AG, Kutkova ON, Votrin II// Minist Publ Hlth USSR lnst Cell Biochem & Physiol, Ctr Biotechnol, Moscow, USSR BULL EXP BIOL MED-ENGL TR 1991, 111 (5) 619 Platelet activation factor inhibits irritant-induced migration of leukocytes into the mouSe peritoneal cavity. Ohar JA, Wailer KS, Demello D, Lagunoff D// St Louis Univ Hosp, Div Pulmonol, 3635 Vista Ave & Grand Blvd, POB 15250, St Louis, MO 63110, USA LAB INVEST 1991,65 (4) 451 Administration of chronic intravenous platelet-activating factor induces pulmonary arterial atrophy and hypertension in rabbits. Adamson LM, Podsiadly B, Smart YC, Stanger JD, Roberts TK’// lUniv Newcastle, Dept Biol Sci, Newcastle, NSW 2308, Australia MOL REPROD DEV 1991,30 (3) 207 Studies on murine embryo-derived plateletactivating factor (EPAF) Chan WP, Levy JV*// lUniv Pacific, Dept Physiol & Pharmacol, 2155 Webster St, San

Francisco, Ca 94115, USA PROSTAGLANDINS 1991,42 (4) 337 Effects of antiplatelet agents on platelet aggregation induced by platelet-activating factor (PAF) in human whole blood. Ye RD, Prossnitz ER, Zou AH, Cochrane CG // Scripps Clin & Res Fdn, Res Inst, Dept Immunol, La Jolla, Ca 92037, USA BIOCHEM BIOPHYS RES COMMUN 1991,180 (1) 105 Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. Meszaros K// Xoma Carp, 2910 7th St, Berkeley, Ca 94710, USA BIOCHEM BIOPHYS RES COMMUN 1991,180 (1) 315 Magnetic field elicits hypotension mediated by platelet activating factor in rats injected 4th iron beads. Coran SA, Bambagiottialberti M, Melani F, Giannellini V, Vincieri FF, Mulinacci N, Sala R, Moriggi E// Univ Florence, Dipartimento Sci Farmaceut, Via Gino Capponi 9, I-50121 Florence, Italy EUR J MED CHEM 1991,26 (6) 643 Synthetic butanolide and tetrahydrofuran lignans with platelet activating factor antagonist activity. Herbert JM, Bemat A, Valette G, Gigo V, Lale A, Laplace MC, Lespy L, Savi P, Maffrand JP, Lefur G// Sanofi Rech, 195 Route Espagne, F-31036 Toulouse, France J PHARMACOL EXP THER 1991,259 (1) 44 Biochemical and pharmacological activities of SR-27417, a highly potent, long-acting pla-

Crowley HJ, Yaremko B, Selig WM, Janero DR, Burghardt C, Welton AF, Odonnell M* // *Hoffmann La Roche Inc, Dept Pharmacol, 340 Kingsland St, Nutley, NJ 07110, USA &PI-IARMACOL EXP THER 1991,259 (1) Pharmacology of a potent platelet-activating factor antagonist - RO 244736. Pritze S, Simmet T, Peskar BA// Ruhr Univ Bochum, Dept Pharmacol & Toxicol, W-4630 Bochum, FRG NAUNYNSCHMIED ARCH PHARMACOL 1991,344 (4) 495 Effect of platelet-activating factor on porcine pulmonary blood vessels in vitro. Colditz IG// CSIRO, Div Anim Hlth, Armidale, NSW 2350, Australia IMMUN CELL BIOL 1991,69 (JUN) P3, 215 The induction of plasma leakage in skin by histamine, bradykinin, activated complement, platelet-activating factor and serotonin. Wood DA, Hapak LK, Sims SM, Dixon ST*// lDiv Oral Biol, Fat Dent, Univ Western Ontario, London, Ontario, Canada N6A SC1 J BIOL CHEM 1991,266 (23) 15369 Direct effects of platelet-activating factor on isolated rat osteoclasts. Rapid elevation of intracellular free calcium and transient retraction of pseudopods. Samiei M, Day-Makin M, Clark-Lewis I, Pelech SL*// *Biomedical Res Ctr, 2222 Health Sci Mall. Univ British Columbia. Vancouver. BC V6T lZ3, Canada J BIOL CHEM 1991,266 (23) 14889 Platelet-activating factor- and thrombin-induced stimulation of p34cdc2cyclin histone Hl kinase activity in platelets. Tarbet EB, Stafforini DM, Elstad MR, Zimmerman GA, McIntyre TM, Prescott SM’ // lCVRTI, Bldg 500, Univ Utah, Salt Lake City, Ut 84112, USA J BIOL CHEM 1991,266 (25) 16667.16673 Liver cells secrete the plasma form of platelet-activating factor acetylhydrolase. Ou M-c, Kawasaki T, Sakon M, Kambayashi J-i, Siba E, Yokota M, Shinoxaki K, Mori T// Hematol Res Lab, Dept Surg II, Osaka Univ Med Sch. l-l-50 Fukushima. Fukushima ku. ’ Osaka S53, Japan BIOCHEM INI 1991,24 (5) 823831 Simple and rapid measurement of platelet-activating factor (PAF) in whole blood. Moxes T, Zijlstra FJ, Heiligers JPC, Tak CJAM, Benefraim S, Bonta IL Saxena PR// Erasmus Univ, Fat Med & Hlth Sci, Dept Pharmacol. Post Box 1738.3000 DR Rotterdam, Netherlands ’ BRIT J PHARMACOL 1991,104 (3) 691 Sequential release of tumour necrosis factor, platelet activating factor and eicosanoids during endotoxin shock in anaesthetixed pigs protective effects of indomethacin.

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Imai Y, Hayashi M, Ohiihi SN lKitasato Inst, Sch Pharmaceut Sci, Dept Pharmacol, 59-1 Shirokane, Minato ku, Tokyo 188, Japan JPN J PHARMACOL 1991.57 (2) 225 Key role of complement activation and platelet-activating factor in exudate formation in zymosan-induced rat pleurisy. Qayumi AK, Jamieson WRE, Poostimdeh A// Univ British Columbia, Dept Surg, Div Cardiovasc & Thorac Su& Room 3180-910 W 10th Ave, Vancouver, BC, Canada V5Z 4E3 ANN THORAC SURG 1991,52 (4) 1026 Effects of platelet-activating factor antagonist CV-3988 in preservation of heart and lung for transplantation. Ved HS, Gustow E, Pieringer RA*// *Temple Univ. Hlth Sci Ct;, Sch Med, Dept Biochem. Philadelnhia. Pa 19148. USA J NEURGSCI ti 1991,30 (2) 353 Regulation of neuronal differentiation in neuron-enriched primary cultures from embryonic rat cerebra by platelet activating factor and the structurally related glycerol ether lipid, dodecylglycerol.

10. METABOLITES Yamaguchi K, Hama I-I// Niigata Univ, Sch Med, Dept Physiol, Asahimachi Dori 1, Niiga ta 951, Japan BRAIN RES 1991,559 (2) 261 Separation of periventricular dopaminergic and alpha-adrenergic systems from the vase pressin-secreting mechanisms activated by prostaglandinD2. Song WC, Brash AR*// *Vanderbilt Univ, Med Ctr, Sch Med, Dept Pharmacol, Nashville, Tn 37232, USA ARCH BIOCHEM BIOPHYS 1991,290 (2) 427 Investigation of the allene oxide pathway in the coral Plexaura homomalla - formation of novel ketols and isomers of prostaglandin& from 15-hydroxyeicosatetraenoic acid. Kanesathasan N, Douglas JG, Kaxura JW*// *Case Western Reserve Univ. Sch Med, Div Geog Med, 2109 Adelbert Rd, Cleveland, Oh 44106, USA MOL BIOCHEM PARASITOL 1991,49 (1) 11 Diethylcarbamazine inhibits endothelial and microfilarial prostanoid metabolism in vitro.

11. RELATED ENZYMES Vila L, Cullare C, Sola J, Puig L, Decastellarnau C, Demoragas JM// Hosp Santa Crux & San Pablo. Inst Recerca Biomed. Casa Convalecencia, Eo8025 Barcelona, Spain J INVEST DERMATOL 1991,97 (5) 922 Cyflooxygenase activity is increased in platelets from psoriatic patients. Corey SJ, Rosoff PM// New England Med Ctr Hosn. DeDt Phvsiol. 136 Harrison Ave. Boston,‘Ma dlll,‘USA J LAB CLIN MED 1991,118 (4) 343 Unsaturated fatty acids and lipoxygenase pro. ducts regulate phagoqtic NADPH oxidase activity by a nondetergent mechanism. Fouke JM, Wolin AD, McFadden ER// Case Western Reserve Univ, Dept Biomed Engn, Cleveland, Oh 44196, USA PROSTAGLANDINS 1991,42 (4) 343 Effects of Ozone on lung mechanics and cyclooxygenase metabolites in dog.

Eknke PJ, Drisko J, Belmat P// Univ Miami, Mailman Ctr Child Dev, Miami, Fl33101,

:I%CHEM MED MEIAB BIOL 1991,46 (2) 226 Chemiluminescence is increased in a subgroup of PHA-stimulated lymphocytes from patients with systemic lupus erythematosus and inhibited by S-lipoxygenase inhibitors. Jain MK, Tao WJ, Rogers J, Arenson C, Eibl H, Yu Bz// Univ Delaware. Deut Chem. New&k, De19716,USA BIOCHEMISIRY-USA 1991.30 (42) 10256 Active-sitedixected specific competitive inhibitors of phospholipaseA2 - novel transition-state analogues. Kuhn H, Eggert L, Zabolotsky OA, Myagkova GI, Schewe T// Humboldt Univ, Med Sch Char&e, Inst B&hem, Hess Str 34,0-1040 Berlin, FRG BIOCHEMISTRY-USA 1991,30 (42) 10269 Keto fatty acids not containing double allylic methylenes are lipoxygenase substrates. Pasechnikov VD, Radsev YA, Guminskij SP // Stavropol Med Inst, Therapeut Dept Nl, UI Aviatsionnaya 21, Stavropol, USSR BIOCHIM BIOPHYS AC-I-A 1991,1097 (1) 45 5lipoxygenase products - their biosynthesis in human gastric mucosa and possible involvement inmfiammatory response and oxygen saturation index reduction in gastric ulcer patients. Maccarrone M, Veldink GA, Vliegenthart JFG’// *State Univ Utrecht, Dept Bioorgan Chem, Bijvoet Ctr Biomolec Res, Padualaan 83584 CH Utrecht, Netherlands FEBS LEIT 1991,291(l) 117 Phytochrome control and anoxia effect on the activity and expression of soybean seedling lipoxygenase-1 and lipoxygenase-2. Decatvalho MS, Jacobs RS*// ‘Univ Calif Santa Barbara, Dept Biol Sci, Santa Barbara, Ca 93106, USA BIOCHEM PHARMA COL 1991,42 (8) 1621 Two-step inactivation of bee venom phospholipasc A2 by scalaradial. Ugarkovic D, Kurelec B, Mulier WEG, Schroder HC// Univ Mainx. Inst Phvsiol Chem, Dept Appl Molec Biol, Duc&ergweg 6, W-6500 Mainx, FRG BULL ENVIRON CONTAM TOXICOL 1991,47 (5) 751 Inhibition of release of phospholipaseA2 from sponge cells (Geodia cydonium) by detergent-polluted sea water - a sensitive method to monitor marine pollution. Sharp JD, White DL, Chiou XG, Goodson T, Gamboa GC, McCiure D, Burgett S, Hoskins JA, Skatrud PL, Sportsman JR, Becker GW, Kang LH, Roberts EF, Kramer RM// Lilly Corporate Center, Indianapolis, In 46285, USA J BIOL CHEM 1991,266 (23) 14850 Molecular cloning and expression of human Ca2 + -sensitive cytosolic phospholipase A2. Myatt EA, Stevens FJ, Sigier PB// Biol & Med Rea Div, Argonne Natl Lab, 9700 S Cass Ave, Argonne, II 60439-l833, USA J BIOL CHEM 1991,266 (25) 16331-16335 Effects of pH and calcium ion on self-association properties of two dimeric phospholipasesA2.

Reynolds I..& Miielich ED, Dennis EA.// lDept Chem, Univ California San Diego, La Jolla, Ca -1, USA J BIOL CHEM 1991,266 (25) 16512-16517 Inhibition of venom phosphoiipases A2 by manoalide and manoalogue. Stoichiometry of incorporation. Roy SK, Kulkami AP*N lUniv S Fiorida, Coli Publ Hlth, Florida Toxicol Res Ctr, Dept Environm & Occupat Hlth, Tampa, Fi 33612. USA CANCER LEIT 1991,60 (1) 33 Lipoxygenase - a new pathway for 2-aminofluorene bioactivation. Sloane DL, Leung R, Craik CS, Sigal E*// *Cardiovasc Res Inst, Univ California, San Francisco, Ca 94143-0911, USA NATURE 1991,354 (6349) 149 A primaly determinant for lipoxygenase positional specificity. Scott DL, White SP, Browning JL, Rosa JJ, Gelb MH, Sigier PB*// l Dept Molec Biophys & Biochem, Howard Hughes Med Inst. Yale Univ, New Haven, Ct 06511, USA SCIENCE 1991,254 (5034) 1087 Structures of free and inhibited human secretoly phospholipase A2 from inflammatory exudate. Taoka H// Mie Univ. Sch Med. Deot Sure 1. 2-174 Edobashi, Tsu; Mie 514, Japan GASIROENTEROL JPN 1991.26 IS1 633 Experimental study on the pathogen&& of acute acalculous cholecystitis, with special reference to the roles of microcirculatory disturbances, free radicals and membranebound phospholipase A2. Xun CQ, Tian ZG, Tai HH*// lUniv Kentucky, Coil Pharm, Div Med Chem & Pharmaceut, Lexington, Ky 40536, USA BIOCHEM J 1991,279 (OCT) Pt 2,553 Stimulation of synthesis de novo of NAD + dependent l5hydroxyprostagiandin dehydtogenase in human promyelocytic leukaemia (HL-60) cells by phorbol ester. Muratova UZ, Bomikov VT, Abdukayumova AK, Saatov TS// Acad Sci UZSSR, Inst Biochem, Tashkent, Uzbekistan, USSR BIOCHEMISTRY-ENGL TR 1991,56 (2) Pt 2,195 Phospholipase A2 activity in human platelets - Isolation and purification of the enzyme. Hoffmann G// Stadt Krankenhaus Bogenhausen, Inst Kiin Chem, Engieschalkingerstr 77, W-8000 Munich 81, FRG CLIN CHEM 1991,37 (10) Pt 1,1799 Utility of serum phospholipase-A measurements (Letter) Kazmiercmk SC, Vanlente F, Hodges ED// E Carolina Univ, Sch Med, Dept Pathol, Gre.enville, NC 27858, USA CLIN CHEM 1991,37 (10) Pt 1,1800 Utility of serum phosphclipase-A measurements - Reply (Letter) Siddiqi AR, Zaidi ZH, Jomvall H*// *Karolinska Inst, Dept Chem 1, S-10401 Stockholm 60, Sweden EUR J BIOCHEM 1991,201(3) 675 Purification and characterixation of two highiy different group-11 phospholipaseA2 isoxymes from a single vipcrid (Eristocophis macmahoni) venom. Naidu AK, Naidu AK, Kulkami AP*// ‘Univ

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S Florida, cdl Pub1HIth, FIorida T&l Res Ctr. MHH-104133Ol Bruce B Doww Bivd, Tampa, Fi 33612, USA PESTIC BIOCHEM PHYSIOL 1991,41(2) 150 Role of lipoxygenase in xenobiotic oxidation Parathion metaboiii cata@ed by highly purified soybean lipoxygenase. Blee E// Inst Biol Mokc PIantes, Inst Bot, Enzymol Celiulaire & Moiec Lab, CNRS, UPR 406,28 Rue Goethe, F-67083 Strasbourg, France Z NATURFORSCH C 1991,46 (9-10) 928 Effect of the safener dichlormid on maize peroxygenase and lipoxygenase. Laughton MJ, Evans PJ, Moroney MA, Hoult JRS*, Halliwell B// *Kings CoU Pharmacol Grp, Manresa Rd, London SW3 6LX, England BIOCHEM PHARMA COL 1991,42 (9) 1673 Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenasc by fiavonoids and phenoiic dietary additives - relationship to antioxidant activity and to iron ion-reducing ability. Wilkerson W, Delucca I, Galbraith W, Gans K, Harris R, Jaffee B, Kerr J// Dupont Co, Dept Med Prod, Exptl Stn E353-347, Wilmington, De 19880, USA EUR J MED CHEM 1991,26 (7) 667 Antiinflammatory phospholipaseA2 inhibitors. 1. Cirino G, Cicala C, Sorrentino L, Regoli D// Univ Naples Federico 2, Dept Exptl Pharmacol, Via Domenico Montesano 49, I-80131 Naples, Italy GEN PHARMACOL 1991,22 (5) 801 Effect of bradykinin antagonists, NG-monomethyl-L-arginine and L-NG-nitro arginine on phospholipase A2 induced oedema in rat paw-

Aizadjali KH, Boyle FC, Ohia SE// Sultan Qaboos Univ, Coil Med, Dept Physiol & Pharmacol, POB 32485, Masqat, Oman GEN PHARMACOL 1991,22 (5) 855 Inhibition of prostagiandin synthetase alters uterine response to adrenoceptor agonists in pregnant and postpartum rats.

12.PRODUCTIONANDRELEA!SE Hsu SY, Goetx FW// Univ Notre Dame, Dept Biol Sci, Notre Dame, In 46556, USA J EXP ZOOL 1991,260 (1) 43 Sodium-orthovanadate induces in vitro ovulation and ovarian prostaglandin synthesis in brook trout (Saivelinus fontinalis) Zarrabeitia MT, Riancho JA, Amado JA, Gonxalexmacias JO// lUniv Cantabria, Hosp M Valdecilla, Dept Internal Med, E-39888 Santander, Spain MEIW FIND EXP CLIN PHARMACOL 1991,13 (8 ) 541 Lack of effect of human parathyroid hormone and calcitonin on cytokine and prostagiandin secretion by blood mononuclear cells. Seelos R, Otto G, Manner M// Univ Heidelberg, Chirurg Klin, INF 110, W-6900 Heidelberg, FRG TRANSPLANT PROC 1991,23 (5) 2428 Prostaglandin synthesis and survival after orthotopic liver transplantation in pigs. Buckley BJ, Kent RS, Whorton ARJJ Div Pulm Med, Box 3177, Duke Univ Med Ctr, Druham, NC 27710, USA

J BIOL CHEM 1991,266 (25) 166.59-16666 Regulation of endothelial cell pmstaglandin synthesis by glutathione. Sjoblom L, Eklund A*, Humble L, Menschiklundin A, Ostlundindqvist AM// lUniv Upusala, Dept Med & Physiol Chem, S75ii3 U&aia, Sweden J NUTR 1991.121~11) 170.5 Plasma vtxy l&v de&&y lipoproteins from male rats fed casein or soytxan protein diets A comparison of fatty acid composition and influence on prostanoid production. Muhlradt PF, Schade U/I &sell Biotechnol For& GmbH, lmmunobiol Res Grp, Maschemdenveg 1, W-3300 Braunschweig, FRG INFEC IMMUNITY 1991,59 (11) 3969 MDHM, a macmphage-stimulatory product of Mycoplasma fermentans, leads to in vitro interleukin-1 (ILl), IM, tumor ne.cmsis factor, and pmstaglandin production and is pymgenic in rabbits. Marusic A, R&z LG.// lUniv Connecticut, Ctr Hlth, Div Endocrinol & Metab, Farmington, Ct 06032, USA ENDOCRINOLOGY 1991,129 (5) 2699 Cortisol modulates the actions of interleukinlalpha on bone formation, resorption, and prostaglandin production in cultured mouse parietal bones. Lemer UH, Modeer TN Umea Univ, Dept Oral Cell Biol, S-90187 Umea, Sweden INFLAMMATION 1991,15 (6) 427 Bradykinin-Bl and bradykinin-B2 nceptor agonists synergistically potentiate interleukinl-induced pmstaglandin biosynthesis in human gingival libmblasts. 13. EFFECTS Uehara Y, Numabe A, Kawabata Y, Nagata T, Hirawa N, Ishimitsu T, Matsuoka H, Ikeda T, Sugimoto T// Univ Tokyo, Dept Med 2,7-3-l Hongo, Bunkyo ku, Tokyo 113, Japan AMER J HYPERTENS 1991,4 (10, Pt 1) 8% Rapid smooth muscle cell wh and endogenous pmstaglandin vtem in spontaneously hypertensive rats. Canning BJ. Hmieleski RR, Spannhake EW, Jakab &*/I *Johns Hopkins univ, Sch Hyg & Publ Hlth. Dent Envimnm Hlth Sci. Baltimore, Md 2i218:USA AMER J PHYSIOL 1991,261(4) Pt 1, L277 Ozone reduces murine alveolar and Fritoneal macmphage phagocytosis - The role of prostanoids. Hobbhahn J, Conzen PF, Habazettl H, Gut-

219 Inhibition of thmmboxane synthetasc potentiates the antihypertensive action of an angiotensin-converting enzyme inhibitor by a prostaglandindependent but kinin-independent mechanism. Manner M, Seelos R, Roy K, Runkel N, Otto G// Univ Heidelberg, Chirurg Klin, INF 110, W-6900 Heidelberg, FRG TRANSPLANI. PROC 1991,23 (5) 2A13 The role of prastaglandins in reperfusion injury after liver transplantation in pigs. Yamaguchi DT, Green 3, Kleeman CR, MualIem S// Vet Adm Med Ctr, Ctr Geriatr Res & Educ & Clin WllG, Wilshire & Sawtelle Blvds, Los Angeles, Ca 90073, USA CELL CALCIUM 1991,12 (9) 609 Pmstaglandins enhance parathyroid hormone-evoked increase in free cytosolic calcium concentration in osteoblast-like cells. Sbibata M, Leffler CW, Busija Dw// Univ Tennessee, Ctr Hlth Sci, Dept Physiol & Biophys, 894 Union Ave, Memphis, Tn 38163, USA AMER J PHYSIOL 1991,261(4) P2, R828 Prostanoids attenuate pial arteriolar dilation induced by cortical spreading depression in rabbits.

14. PROSTAGLANDINS IN MEDICINE Glavin GB// Univ Manitoba, Fat Med, Dept Pharmacol& Therapeut, Winnipeg, Manitoba, Canada R3T 2N2 PROSTAGLANDINS 1991,42 (4) 289 Basic fibmblast gmwth factor and gastrointestinal pathology (Editorial) R Bath W. Adelmannerill BC. Fittkow C, Szeverenyl fi, Kuhn W; Univ bottinmann R, Kellermann W, Peter K// Univ Munich, Klinikum Gmsshadem, Inst Anesthesi01, Marehoninistr 15, W-8000 Munich 70, &mers

?zPL PHYSIOL 1991,71(4) 1415 Heparin reversal-by pmtamine in humans Complement, prostaglandins, blood cells, and hemodynamics.

gen, Frauen Klin, Robert Koch Str 40, W3400 Gottingen, FRG EUR J OBslET GYN REPROD BIOL 1991,42 (1) 29 Collagenase activity in the human cervix uteri after prostaglandin E2 application during tbe 1st trimester.

15. PROSTAGLANDINS AS DRUGS Bncski M, Madhok R, Capell HA// Stoke Mandeville Hosp, Rheumat Dii Rcf Ctr, Aylesbuly HP21 8AL, Bucks, England BRIT J RHEUMATOL 1991,30 (5) 370 Evening primrose oil in patients with rbeumatoid arthritis and side-effects of non-steroidal anti-inflammatory drugs. Small RE, Wilmotpater MG, Mcgee BA, Willii HE0 Virginia Commonwealth Univ, Med Coil Virginia, Box 533, MCV Stn, Richmond, Va 23298, USA CLIN P-0 1991,lO (11) 870 Effects of misopmstol or ranitidine on ibupmfen pharmacokinetics. Lohde E, Luck M, Raude H, Kuhn F, Abri 0, Kraas E// Acad Hosp Moabit, Dept Surg, Turmstr.21, W-1000 Berlin 21, FRG TRANSPLANT PROC 1991,23 (5) 2432 Influence of ilopmst on insulin synthesis in isolated human islets of Langerhans. Goodlad RA, Mandir N, Levin S, Allen JL, Wright NA// Imperial Cant Res Fund, Hiitopathol Unit, 3543 Lincolns Inn Field, London WC2A 3PN, England GA!XROENIEROLOGY 1991,101(S) 1229 Prostaglandins and the mlonic epithelium Effects of misopmstol on crypt size, au pm dudion, and cell migration ii the dog, _

19. TECHNIQUES Komum Y, Ishibara K, Obara S, Saigenji K, Hotta K’// ‘Kitasato Univ, Sch Med, Dept Biocbem, Sagamihara, Kanagawa 228, Japan GASIROENI’EROL JPN 1991,26 (5) 582 A new method of separation and quantitiation of mucus glympmtein in rat gastric mucus gel layer and its application to mucus secretion induced by 16,16dimethyl PGE2.

Lopez Y, Fioramonti J, Bueno U/ INRA BP 3. Dept Pharmacol. F-31931 Toulouse, France PROS~AGLAND~NS 1991,42 (4) 313 fie bibliography which appears in this journal is Action of endogenous prostaglandins on alSo available on subscription, on a fortnighdy postprandial pyloric motility - A possible basis. from Sheffield University Biomedical modulation by fats. Information Service. Sheffield S10 2TN. UK. It hens NR, ate D, Ksander G// Ciba Geigy is entitled ‘Prostaglmh - Biology’ (ISSN 0142-8284) and COSTS f76.00 (also available on AG, K 125 908, CH4002 Basel, Switzerland J PHARMACOL EX,P TI-IER 1991,259 (1) diskette at fdO.OQ.

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