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A novel disintegrin metalloprotease and methods of use (MH Tindal and T Haqqi, US)
of a TGF-0 activator, specifically a plasminogen activator, for the production of an axial elongation inhibitor... Use of a TGF-P activation inhibitor, particularly a plasminogen activator inhibitor, for the production of an axial elongation agent... 5 The use of a gonadotropin releasing hormone analog or mime thereof for the preparation of a pharmaceutical composition as an adjunctive for the invasive treatment of carcinomas (GD Hodgen, US) The Medical College of Hampton Roads N"796622,EP
> Antithrombotic (VJ Klimkowski Wiley, US) Eli Lilly and Co
diamides and MR
can alleviate symptoms of AIDS by inhibiting binding of HIV, the virus associated with AIDS, to receptor sites in human cells susceptible to HIV infection. These peptidomimetics, in particular, inhibit binding of HIV to cells of brain membrane and the immune system. They also display substantially longer halt-lives in vivo than peptide T... The compounds of this invention, alone or in combination, can further be used to prevent development of AIDS in persons who might become exposed to HIV. > A novel disintegrin metalloprotease and methods of use (MH Tindal and T Haqqi, US) The Procter & Gamble Co, Case Western Reserve University and the inventors
N"796866,EK
N"W0
.. . This invention relates to a compound or a pharmaceutically acceptable salt... and methods of their use as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders. > Methods and compositions for protective and therapeutic genetic immunization (J Lisziewicz and F Lori, US) Research Institute for Genetic and Human Therapy N"WO97/31119,
PCT.
... Specifically, the attenuated non-pathogenic viral particles of the subject invention which produce the therapeutic or preventative immune response are generated by cells in the lymphoid organs such that the release of the viral particles occurs in the location within the human or animal body where antiviral responses are generated by cells of the immune system. The release of the virus particles in the lymphoid organs is achieved by transducing host cells (dendritic cells) of the lymphoid organs... with a genetic construct which results in expression of the attenuated virus... z Peptidomimetics for the treatment of HIV infection (MR Pincus et al, US) lnnapharma Inc N"WO97/31628,PCT.
More specifically, peptidomimetics of this invention . ..
42 B10FUTUR173
l
Dkxmbre1997
97131931,
PCT.
This invention also provides an in vivo or in vitro method for screening for osteoarthritis and other metalloprotease based diseases, capable of manufacture and use in a kit form. .. .
z Use of a pharmaceutical composition comprising an appetite-suppressing peptide (L Thim et a/, DK) Novo Nordisk A/S N”W0 97131943,PCT. Appetite-suppressing peptide or an appetite-suppressing peptide-containing fraction for the treatment of obesity or type II diabetes. > Adapter molecules for targeting viral particles to cells (AJ Kingsman and SM Kingsman, RU) Oxford Biomedica Ltd and the inventors N” WO 97132026, PCT. ... The adapter molecules are useful in gene therapy, for targeting retroviral delivery vectors to specific cell types. > Vecteurs adbnoviraux recombin& pour lath&apie g6nique des tumeurs humaines (F Boon et al, BE, FR) Rh6ne-Poulenc Rorer, Ludwig Institute for Cancer Research and the inventors N” WO 97134009. PCT. > Selected oligonucleotides with anti-cytomegalovirus activity (GS Pari, US)
Hybridon Inc N” WO 97133992, PCT. ... The present invention further provides therapeutic compositions comprising the novel oligonucleotides of the invention, and method of preparing medicaments comprising the novel oligonucleotides of the invention. > Protection of hemopoietic cells during chemotherapy or radiotherapy (J Wdzieczak-Bakala et a/, FR) Soci& de conseils de recherches et d’applications scientifiques, lnserm et les inventeurs N” WO 97/34627, PCT. A method of promoting regeneration of hemopoietic cells in a subject undergoing chemotherapy or radiotherapy, which method includes administering to the subject and angiotensin-converting enzyme inhibitor...
z An enzyme with galactanase activity (LV Kofod et al, DK) Novo Nordisk AIS and the inventors N” WO 97132013, 97/32014, PCT. ... a detergent composition comprising said galactanase, and the use of said enzyme and enzyme composition for a number of industrial applications.
> Process and test kit for non-radioactive enzymatic detection of reverse transcriptase (0 Faff and AG Hisem, DE) Retrotech GmbH Gesellschaft fijr Retrovirale Technologie and the inventors N” WO 97/32995, PCT. ... The process can be used under appropriately optimised reaction conditions with all species of retroviruses and reverse transcriptpases and can be used for the direct detection of retroviruses in cases of viral diseases, in transfusion and transplants medicine... and in biological quality control
of biopharmaceutical and biotechnology products.
> Soybean cysteine proteinase inhibitors, nucleotides encoding the same, and methods of use thereof (2 Nielsen et a/, US) Purdue Research Foundation and the inventors N” WO 97132007, PCT. The invention relates to the isolation, purification and use of three soybean cysteine proteinase inhibitors, designated Ll, Rl and N2, which have strong inhibitory activity with respect to cysteine proteinases found in the digestive tracts of certains herbovirus insects... The invention also relates to plant transformed by inventive vectors, transformed plants having an enhanced ability to resist predation by said insects, as well as microorganisms transformed using inventive vectors or plasmids.
> Arfhrobacter sp and its use for the desulfuration of fossil fuels (E Fascetti et al, IT) Eniricerche SpA N” 795603, EP. > Apparatus for degrading pollutant, process for purifying contaminated medium and process for degrading pollutant (Y Okubo et al, JP) Canon Kabushiki Kaisha N” 801033, EP. > Pro&d6 et installation de traitement des dechets organiques et application dudit pm&d6 (CA Lasseur et al, NL, BER) Agence spatiale europt+enne et les inventeurs N” WO 97/31120, PCT. ... I1 trouve notamment application dans le recyclage des dCchets organiques d’origine animale du type lisiers ou purins ou celui des boues issues de l’ipuration des eaux. > System for removing nutrients from wastewater (LA Schmid, US)
> Antithrombotic (VJ Klimkowski Wiley, US) Eli Lilly and Co
diamides and MR
can alleviate symptoms of AIDS by inhibiting binding of HIV, the virus associated with AIDS, to receptor sites in human cells susceptible to HIV infection. These peptidomimetics, in particular, inhibit binding of HIV to cells of brain membrane and the immune system. They also display substantially longer halt-lives in vivo than peptide T... The compounds of this invention, alone or in combination, can further be used to prevent development of AIDS in persons who might become exposed to HIV. > A novel disintegrin metalloprotease and methods of use (MH Tindal and T Haqqi, US) The Procter & Gamble Co, Case Western Reserve University and the inventors
N"796866,EK
N"W0
.. . This invention relates to a compound or a pharmaceutically acceptable salt... and methods of their use as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders. > Methods and compositions for protective and therapeutic genetic immunization (J Lisziewicz and F Lori, US) Research Institute for Genetic and Human Therapy N"WO97/31119,
PCT.
... Specifically, the attenuated non-pathogenic viral particles of the subject invention which produce the therapeutic or preventative immune response are generated by cells in the lymphoid organs such that the release of the viral particles occurs in the location within the human or animal body where antiviral responses are generated by cells of the immune system. The release of the virus particles in the lymphoid organs is achieved by transducing host cells (dendritic cells) of the lymphoid organs... with a genetic construct which results in expression of the attenuated virus... z Peptidomimetics for the treatment of HIV infection (MR Pincus et al, US) lnnapharma Inc N"WO97/31628,PCT.
More specifically, peptidomimetics of this invention . ..
42 B10FUTUR173
l
Dkxmbre1997
97131931,
PCT.
This invention also provides an in vivo or in vitro method for screening for osteoarthritis and other metalloprotease based diseases, capable of manufacture and use in a kit form. .. .
z Use of a pharmaceutical composition comprising an appetite-suppressing peptide (L Thim et a/, DK) Novo Nordisk A/S N”W0 97131943,PCT. Appetite-suppressing peptide or an appetite-suppressing peptide-containing fraction for the treatment of obesity or type II diabetes. > Adapter molecules for targeting viral particles to cells (AJ Kingsman and SM Kingsman, RU) Oxford Biomedica Ltd and the inventors N” WO 97132026, PCT. ... The adapter molecules are useful in gene therapy, for targeting retroviral delivery vectors to specific cell types. > Vecteurs adbnoviraux recombin& pour lath&apie g6nique des tumeurs humaines (F Boon et al, BE, FR) Rh6ne-Poulenc Rorer, Ludwig Institute for Cancer Research and the inventors N” WO 97134009. PCT. > Selected oligonucleotides with anti-cytomegalovirus activity (GS Pari, US)
Hybridon Inc N” WO 97133992, PCT. ... The present invention further provides therapeutic compositions comprising the novel oligonucleotides of the invention, and method of preparing medicaments comprising the novel oligonucleotides of the invention. > Protection of hemopoietic cells during chemotherapy or radiotherapy (J Wdzieczak-Bakala et a/, FR) Soci& de conseils de recherches et d’applications scientifiques, lnserm et les inventeurs N” WO 97/34627, PCT. A method of promoting regeneration of hemopoietic cells in a subject undergoing chemotherapy or radiotherapy, which method includes administering to the subject and angiotensin-converting enzyme inhibitor...
z An enzyme with galactanase activity (LV Kofod et al, DK) Novo Nordisk AIS and the inventors N” WO 97132013, 97/32014, PCT. ... a detergent composition comprising said galactanase, and the use of said enzyme and enzyme composition for a number of industrial applications.
> Process and test kit for non-radioactive enzymatic detection of reverse transcriptase (0 Faff and AG Hisem, DE) Retrotech GmbH Gesellschaft fijr Retrovirale Technologie and the inventors N” WO 97/32995, PCT. ... The process can be used under appropriately optimised reaction conditions with all species of retroviruses and reverse transcriptpases and can be used for the direct detection of retroviruses in cases of viral diseases, in transfusion and transplants medicine... and in biological quality control
of biopharmaceutical and biotechnology products.
> Soybean cysteine proteinase inhibitors, nucleotides encoding the same, and methods of use thereof (2 Nielsen et a/, US) Purdue Research Foundation and the inventors N” WO 97132007, PCT. The invention relates to the isolation, purification and use of three soybean cysteine proteinase inhibitors, designated Ll, Rl and N2, which have strong inhibitory activity with respect to cysteine proteinases found in the digestive tracts of certains herbovirus insects... The invention also relates to plant transformed by inventive vectors, transformed plants having an enhanced ability to resist predation by said insects, as well as microorganisms transformed using inventive vectors or plasmids.
> Arfhrobacter sp and its use for the desulfuration of fossil fuels (E Fascetti et al, IT) Eniricerche SpA N” 795603, EP. > Apparatus for degrading pollutant, process for purifying contaminated medium and process for degrading pollutant (Y Okubo et al, JP) Canon Kabushiki Kaisha N” 801033, EP. > Pro&d6 et installation de traitement des dechets organiques et application dudit pm&d6 (CA Lasseur et al, NL, BER) Agence spatiale europt+enne et les inventeurs N” WO 97/31120, PCT. ... I1 trouve notamment application dans le recyclage des dCchets organiques d’origine animale du type lisiers ou purins ou celui des boues issues de l’ipuration des eaux. > System for removing nutrients from wastewater (LA Schmid, US)