CUMULATIVE NCE INTRODUCTION INDEX, 1983-1987 GENERIC NAME AF-2259 APD APSAC acetohydroxamic acid acipimox adamantanium bromide adrafinil afloqualone alclometasone dipropionate alfentanil HC1 alminoprofen alteplase amfenac sodium amisulpride amlexanox amrinone amsacrine arotinolol HC1 artemisinin aspoxicillin astemizole astromycin sulfate auranofin azelastine HC1 azosemide aztreonam beclobrate befunolol HC1 benexate HC1 betaxolol HC1 bevantolol HC1 bifemelane HC1 bifonazole binifibrate bisoprolol fumarate bopindolol brotizolam brovincamine fumarate bucillamine bucladesine sodium budralazine bunazosin HC1 buserelin acetate buspirone HC1 butoconazole nitrate butoctamide succinate butyl flufenamate cadexomer iodine camostat mesylate carboplatin cefbuperazone sodium cefixime cefmenoxime HC1
INDICATION
YEAR INTRODUCED
ARMC VOL.,PAGE
antiinflammatory calcium regulator thrombolytic hypoammonuric hypolipidemic antiseptic psychostimulant muscle relaxant topical antiinflammatory
1987 1987 1987 1983 1985 1984 1986 1983 1985
23, 325 23, 326 23, 326 19, 313 21, 323 20, 315 22, 315 19, 313 21, 323
analgesic analgesic thrombolytic antiinflammatory antipsychotic antiasthmatic cardiotonic antineoplastic antihypertensive antimalarial antibiotic antihistamine antibiotic chrysotherapeutic antihistamine diuretic antibiotic hypolipidemic antiglaucoma antiulcer antihypertensive antihypertensive nootropic hypnotic hypo1ipidemic antihypertensive antihypertensive hypnotic cerebral vasodilator immunomodulator cardiostimulant antihypertensive antihypertensive hormone anxiolytic topical antifungal hypnotic topical antiinflammatory wound healing agent protease inhibitor antineoplastic antibiotic antibiotic antibiot ic
1983 1983 1987 1986 1986 1987 1983 1987 1986 1987 1987 1983 1985 1983 1986 1986 1984 1986 1983 1987 1983 1987 1987 1983 1986 1986 1985 1983 1986 1987 1984 1983 1985 1984 1985 1986 1984 1983 1983 1985 1986 1985 1987 1983
19, 314 19, 314 23, 326 22, 315 22, 316 23, 327 19, 314 23, 327 22, 316 23, 327 23, 328 19, 314 21, 324 19, 314 22, 316 22, 316 20, 315 22, 317 19, 315 23, 328 19, 315 23, 328 23, 329 19, 315 22, 317 22, 317 21, 324 19, 315 22, 317 23, 329 20, 316 19, 315 21, 324 20, 316 21, 324 22, 318 20, 316 19, 316 19, 316 21, 325 22, 318 21, 325 23, 329 19, 316
380
CUMULATIVE NCE INTRODUCTION INDEX, 1983-1987
GENERIC NAME
INDICATION
YEAR INTRODUCED
cefminox sodium antibiotic cefonicid sodium antibiotic ceforanide antibiotic cefotetan disodium antibiotic cefpimizole antibiotic cefpiramide sodium antibiotic ceftazidime antibiotic cefteram pivoxil antibiotic cefuroxime axetil antibiotic cefuzonam sodium antibiotic celiprolol HC1 antihypertensive cetirizine HC1 antihistamine chenodiol anticholelithogenic cibenzoline antiarrhythmic cimetropium bromide antispasmodic ciprofibrate hypolipidemic ciprofloxacin antibacterial cloconazole HC1 topical antifungal clodronate disodiun calcium regulator cyclosporine immunosuppressant dapiprazole HC1 antiglaucoma defibrotide antithrombotic deflazacort antiinflammatory diacerein antirheumatic divistyramine hypocholesterolemic doxefazepam hypnotic doxifluridine antineoplastic doxofylline bronchodilator dronabinol antinauseant emorfazone analgesic enalapril maleate antihypertensive enalaprilat antihypertensive encainide HC1 antiarrhythmic enocitab ine antineoplastic enoxacin antibacterial enoxaparin antithrombotic enprosti1 antiulcer eperisone HC1 muscle relaxant epidermal growth wound healing agent factor epirubicin HC1 antineoplastic epoprostenol sodium platelet aggreg. inhib eptazocine HBr analgesic esmolol HC1 antiarrhythmic etizo lam anxiolytic etodolac antiinflammatory famotidine antiulcer felb inac topical antiinflammatory fenbuprol choleretic fenticonazole nitrate antifungal fisalamine intestinal antiinflam. flumazenil benzodiazepine antag. flunoxaprofen antiinflammatory fluoxetine HC1 antidepressant flupirtine maleate analgesic flutamide antineoplastic flutazolam anxiolvtic flutoprazepam anxiolytic
ARMC VOL. , PAGE
1987 1984 1984 1984 1987 1985 1983 1987 1987 1987 1983 1987 1983 1985 1985 1985 1986 1986 1986 1983 1987 1986 1986 1985 1984 1985 1987 1985 1986 1984 1984 1987 1987 1983 1986 1987 1985 1983 1987
23, 330 20, 316 20, 317 20, 317 23, 330 21, 325 19, 316 23, 330 23, 331 23, 331 19, 317 23, 331 19, 317 21, 325 21, 326 21, 326 22, 318 22, 318 22, 319 19, 317 23, 332 22, 319 22, 319 21, 326 20, 317 21, 326 23, 332 21, 327 22, 319 20, 317 20, 317 23, 332 23, 333 19, 318 22, 320 23, 333 21, 327 19, 318 23, 333
1984 1983 1987 1987 1984 1985 1985 1986 1983 1987 1984 1987 1987 1986 1985 1983 1984 1986
20, 318 19, 318 23, 334 23, 334 20, 318 21, 327 21, 327 22, 320 19, 318 23, 334 20, 318 23, 335 23, 335 22, 320 21, 328 19, 318 20, 318 22, 320
381
CUMULATIVE NCE INTRODUCTION INDEX, 1983-1987 GENERIC NAME fluvoxamine maleate formoterol fumarate fosfosal gallopamil HC1 gemepros t ges todene gestrinone goserelin gosere1in guanadrel sulfate halometasone hydrocortisone butyrate propionate ibopamine HC1 idebenone imipenem/cilastatin indalpine indobufen isofezolac isoxicam ivermectin ketanserin lenampicillin HC1 lentinan leuprolide acetate levacecarnine HC1 levobunolol HC1 lidamidine HC1 lisinopril lobenzarit sodium lonidamine loprazolam mesylate lovastatin loxoprofen sodium mabuterol HC1 malotilate medifoxamine fumarate mefloquine HC1 me gluto 1 melinamide mepixanox meptazinol HC1 metaclazepam metapramine mexazolam miokamycin misoprostol mitoxantrone HC1 mizoribine mometasone furoate mup irocin muromonab-CD3 muzolimine nabumetone nafamostat mesylate naftifine HC1 naltrexone HC1 nedocromil sodium nicorandil
*
INDICATION
YEAR INTRODUCED
ARMC VOL.,PAGE
antidepressant bronchodilator analgesic antianginal abortifacient progestogen antiprogestogen hormone hormone antihypertensive topical antiinflammatory topical antiinflammatory
1983 1986 1984 1983 1983 1987 1986 1986 1987 1983 1983 1983
19, 319
cardiostimulant nootropic antibiotic antidepressant antithrombotic antiinflammatory antiinflammatory antiparasitic antihypertensive antibiotic immunostimulant hormone nootropic antiglaucoma antiperistaltic antihypertensive antiinflammatory antineoplastic hypnotic hypocholesterolemic antiinflammatory bronchodilator hepatoprotective antidepressant antimalarial hypolipidemic hypocholesterolemic analeptic analges ic anxiolytic antidepressant anxiolytic antibiotic antiulcer antineoplastic immunosuppressant topical intiinflammatory topical antibiotic immunosuppressant diuretic antiinflammatory protease inhibitor antifungal narcotic antagonist antiallergic coronary vasodilator
1984 1986 1985 1983 1984 1984 1983 1987 1985 1987 1986 1984 1986 1985 1984 1987 1986 1987 1983 1987 1986 1986 1985 1986 1985 1983 1984 1984 1983 1987 1984 1984 1985 1985 1984 1984 1987 1985 1986 1983 1985
20, 319 22, 321 21, 328 19, 320 20, 319 20, 319 19, 320 23, 336 21, 328 23, 336 22, 322 20, 319 22, 322 21, 328 20, 320 23, 337 22, 322 23, 337 19, 321 23, 337 22, 322 22, 323 21, 329 22, 323 21, 329 19, 321 20, 320 20, 320 19, 321 23, 338 20, 320 20, 321 21, 329 21, 329 20, 321 20, 321 23, 338 21, 330 22, 323 19, 321 21, 330 22, 323 20, 321 20, 322 22, 324 20, 322
1986
1984 1984
1986
1984
22, 321 20, 319 19, 319 19, 319 23, 335 22, 321 22, 321 23, 336 19, 319 19, 320 19, 320
382
CUMULATIVE NCE INTRODUCTION INDEX, 1983-1987
GENERIC NAME INDICATION YEAR INTRODUCED nilutamide antineoplastic 1987 nimesulide antiinflammatory 1985 nimodipine cerebral vasodilator 1985 nitrefazole * alcohol deterrent 1983 nitrendipine antihypertensive 1985 nizatidine antiulcer 1987 nomegestrol acetate progestogen 1986 norfloxacin antibacterial 1983 norgestimate progestogen 1986 ofloxacin antibacterial 1985 ornoprostil antiulcer 1987 osalazine sodium intestinal antiinflam. 1986 oxaprozin antiinflammatory 1983 oxiconazole nitrate antifungal 1983 oxiracetam nootropic 1987 oxitropium bromide bronchodilator 1983 pefloxacin mesylate antibacterial 1985 picotamide antithrombotic 1987 piketoprofen topical antiinflammatory 1984 pimaprofen topical antiinflammatory 1984 pinacidil antihypertensive 1987 plaunoto1 antiulcer 1987 prednicarbate topical antiinflammatory 1986 progabide anticonvulsant 1985 promegestone progestogen 1983 propacetamol HC1 analgesic 1986 propofol anesthetic 1986 quazepam hypnotic 1985 quinfamide amebicide 1984 ranimustine antineoplastic 1987 repirinast antiallergic 1987 rifaximin antibiotic 1985 rifaximin antibiotic 1987 rimantadine HC1 antiviral 1987 rokitamycin antibiotic 1986 ronafibrate hypolipidemic 1986 rosaprostol antiulcer 1985 roxaiidine acetate HC1 antiulcer 1986 roxithromycin antibiotic 1987 schizophyllan immunostimulant 1986 setastine HC1 antihistamine 1987 sodium cellulose PO4 hypocalciuric 1983 sofalcone antiulcer 1984 somatropin hormone 1987 spizofurone antiulcer 1987 sufentanil analges ic 1983 sulbactam sodium B-lactamase inhibitor 1986 sulconizole nitrate topical antifungal 1985 sultamycillin tosylate antibiotic 1987 suprofen analgesic 1983 surfactant TA respiratory surfactant 1987 temocillin disodium antibiotic 1984 tenoxicam antiinflammatory 1987 teprenone antiulcer 1984 terazosin HC1 antihypertensive 1984 terconazole antifungal 1983 tertatolol HC1 antihypertensive 1987 thymopentin immunomodulator 1985
ARMC VOL.,PAGE
23, 338 21, 330 21, 330 19, 322 21, 331 23, 339 22, 324 19, 322 22, 324 21, 331 23, 339 22, 324 19, 322 19, 322 23, 339 19, 323 21, 331 23, 340 20, 322 20, 322 23, 340 23, 340 22, 325 21, 331 19, 323 22, 325 22, 325 21, 332 20, 322 23, 341 23, 341 21, 332 23, 341 23, 342 22, 325 22, 326 21, 332 22, 326 23, 342 22, 326 23, 342 19, 323 20, 323 23, 343 23, 343 19, 323 22, 326 21, 332 23, 343 19, 324 23, 344 20, 323 23, 344 20, 323 20, 323 19, 324 23, 344 21. 333
383
CUMJLATIVE NCE INTRODUCTION INDEX, 1983-1987 GENERIC NAME tianeptine sodium timiperone tioconazole tiquizium bromide tiropramide H C 1 tizanidine toloxatone trientine HC1 trimazosin HC1 troxipide ubenimex z idovudine zopiclone zuclopenthixol acetate
*
=
withdrawn
INDICATION antidepressant neuroleptic antifungal antispasmodic antispasmodic muscle relaxant antidepressant chelator antihypertensive antiulcer immunostimulant antiviral hypnotic antipsychotic
YEAR INTRODUCED
1983 1984 1983 1984 1983 1984 1984 1986 1985 1986 1987 1987 1986 1987
ARMC VOL.,PAGE
19, 324 20, 323 19, 324 20, 324 19, 324 20, 324 20, 324 22, 327 21, 333 22, 327 23, 345 23, 345 2 2 , 327 23, 345