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Cumulative NCE Introduction Index, 1983–2013
CUMULATIVE NCE INTRODUCTION INDEX, 1983–2013 GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
abacavir sulfate abarelix abatacept abiraterone acetate acarbose aceclofenac acemannan acetohydroxamic acid acetorphan acipimox acitretin aclidinium bromide
antiviral anticancer antiarthritic anticancer antidiabetic antiinflammatory wound healing agent urinary tract/bladder disorders antidiarrheal antihypercholesterolemic antipsoriasis chronic obstructive pulmonary disorder dyspepsia antiallergy antiinflammatory antiarthritic antibacterial antiviral anticancer
1999 2004 2006 2011 1990 1992 2001 1983 1993 1985 1989 2012
35 (333) 40 (446) 42 (509) 47 (505) 26 (297) 28 (325) 37 (259) 19 (313) 29 (332) 21 (323) 25 (309) 48 (481)
2013 1988 1994 2003 1984 2002 2013
49 (447) 24 (295) 30 (296) 39 (267) 20 (315) 38 (348) 49 (449)
sleep disorders antiinflammatory anticancer ophthalmologic, macular degeneration muscle relaxant Fabry’s disease antihypertensive ophthalmologic (allergic conjunctivitis) antiinflammatory
1986 1987 2013 2011
22 (315) 23 (325) 49 (451) 47 (507)
1983 2001 1988 2010
19 (313) 37 (259) 24 (296) 46 (444)
1985
21 (323)
antipsoriasis anticancer osteoporosis analgesic antihypertensive Gaucher’s disease Pompe disease antihypertensive anticancer
2003 2001 1993 1983 1988 1991 2006 2007 1999
39 (267) 37 (260) 29 (332) 19 (314) 24 (296) 27 (321) 42 (511) 43 (461) 35 (333)
acotiamide acrivastine actarit adalimumab adamantanium bromide adefovir dipivoxil ado-trastuzumab emtansine adrafinil AF-2259 afatinib aflibercept afloqualone agalsidase alfa alacepril alcaftadine alclometasone dipropionate alefacept alemtuzumab alendronate sodium alfentanil hydrochloride alfuzosin hydrochloride alglucerase alglucosidase alfa aliskiren alitretinoin
543
544
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
alminoprofen almotriptan alogliptin alosetron hydrochloride alpha-1 antitrypsin alpidem alpiropride alteplase alvimopan ambrisentan amfenac sodium amifostine aminoprofen amisulpride amlexanox amlodipine besylate amorolfine hydrochloride amosulalol ampiroxicam amprenavir amrinone amrubicin hydrochloride amsacrine amtolmetin guacil anagliptin anagrelide hydrochloride anakinra anastrozole angiotensin II anidulafungin aniracetam anti-digoxin polyclonal antibody APD apixaban apraclonidine hydrochloride aprepitant APSAC aranidipine arbekacin arformoterol argatroban arglabin aripiprazole
analgesic antimigraine antidiabetic irritable bowel syndrome emphysema anxiolytic antimigraine antithrombotic post-operative ileus pulmonary hypertension antiinflammatory cytoprotective antiinflammatory antipsychotic antiasthma antihypertensive antifungal antihypertensive antiinflammatory antiviral congestive heart failure anticancer anticancer antiinflammatory antidiabetic antithrombotic antiarthritic anticancer anticancer adjuvant antifungal cognition enhancer antidote, digoxin poisoning
1983 2000 2010 2000 1988 1991 1988 1987 2008 2007 1986 1995 1990 1986 1987 1990 1991 1988 1994 1999 1983 2002 1987 1993 2012 1997 2001 1995 1994 2006 1993 2002
19 (314) 36 (295) 46 (446) 36 (295) 24 (297) 27 (322) 24 (296) 23 (326) 44 (584) 43 (463) 22 (315) 31 (338) 26 (298) 22 (316) 23 (327) 26 (298) 27 (322) 24 (297) 30 (296) 35 (334) 19 (314) 38 (349) 23 (327) 29 (332) 48 (483) 33 (328) 37 (261) 31 (338) 30 (296) 42 (512) 29 (333) 38 (350)
osteoporosis antithrombotic antiglaucoma
1987 2011 1988
23 (326) 47 (509) 24 (297)
antiemetic antithrombotic antihypertensive antibacterial antiasthma antithrombotic anticancer antipsychotic
2003 1987 1996 1990 2007 1990 1999 2002
39 23 32 26 43 26 35 38
(268) (326) (306) (298) (465) (299) (335) (350)
545
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
armodafinil arotinolol hydrochloride arteether artemisinin asenapine aspoxicillin astemizole astromycin sulfate atazanavir atomoxetine
INDICATION
sleep disorders antihypertensive antimalarial antimalarial antipsychotic antibacterial antiallergy antibacterial antiviral attention deficit hyperactivity disorder atorvastatin calcium antihypercholesterolemic atosiban premature labor atovaquone antiparasitic auranofin antiarthritic avanafil male sexual dysfunction axitinib anticancer azacitidine anticancer azelaic acid acne azelastine hydrochloride antiallergy azelnidipine antihypertensive azilsartan antihypertensive azithromycin antibacterial azosemide diuretic aztreonam antibacterial balofloxacin antibacterial balsalazide disodium ulcerative colitis bambuterol antiasthma barnidipine hydrochloride antihypertensive beclobrate antihypercholesterolemic bedaquiline antibacterial befunolol hydrochloride antiglaucoma belatacept immunosuppressant belimumab lupus belotecan anticancer benazepril hydrochloride antihypertensive benexate hydrochloride antiulcer benidipine hydrochloride antihypertensive beraprost sodium antiplatelet besifloxacin antibacterial betamethasone butyrate antiinflammatory propionate betaxolol hydrochloride antihypertensive betotastine besilate antiallergy bevacizumab anticancer
YEAR ARMC VOL., INTRODUCED (PAGE)
2009 1986 2000 1987 2009 1987 1983 1985 2003 2003
45 (478) 22 (316) 36 (296) 23 (327) 45 (479) 23 (328) 19 (314) 21 (324) 39 (269) 39 (270)
1997 2000 1992 1983 2011 2012 2004 1989 1986 2003 2011 1988 1986 1984 2002 1997 1990 1992 1986 2012 1983 2011 2011 2004 1990 1987 1991 1992 2009 1994
33 (328) 36 (297) 28 (326) 19 (314) 47 (512) 48 (485) 40 (447) 25 (310) 22 (316) 39 (270) 47 (514) 24 (298) 22 (316) 20 (315) 38 (351) 33 (329) 26 (299) 28 (326) 22 (317) 48 (487) 19 (315) 47 (516) 47 (519) 40 (449) 26 (299) 23 (328) 27 (322) 28 (326) 45 (482) 30 (297)
1983 2000 2004
19 (315 36 (297) 40 (450)
546
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
bevantolol hydrochloride bexarotene biapenem bicalutamide bifemelane hydrochloride bilastine bimatoprost binfonazole binifibrate biolimus drug-eluting stent
antihypertensive anticancer antibacterial anticancer nootropic antiallergy antiglaucoma sleep disorders antihypercholesterolemic coronary artery disease, antirestenotic anticancer antihypertensive antithrombotic antipsychotic antiviral antihypertensive anticancer antihypertensive anticancer anticancer antiglaucoma antiglaucoma antibacterial antiinflammatory sleep disorders cerebral vasodilator immunomodulator congestive heart failure Parkinson’s disease antihypertensive antimalarial antihypertensive antidepressant hormone therapy anxiolytic antifungal antiinflammatory antifungal sleep disorders antiinflammatory anticancer antiprolactin anticancer wound healing agent
1987 2000 2002 1995 1987 2010 2001 1983 1986 2008
23 (328) 36 (298) 38 (351) 31 (338) 23 (329) 46 (449) 37 (261) 19 (315) 22 (317) 44 (586)
1990 1986 2000 2008 2011 1985 2003 2001 2012 2011 1996 1998 1993 1997 1983 1986 1987 1984 1997 1983 2000 1985 1989 1984 1985 1992 1992 1986 1984 1983 2010 1993 2012 1983
26 (300) 22 (317) 36 (298) 44 (587) 47 (521) 21 (324) 39 (271) 37 (262) 48 (489) 47 (523) 32 (306) 34 (318) 29 (333) 33 (329) 19 (315) 22 (317) 23 (329) 20 (316) 33 (330) 19 (315 36 (299) 21 (324) 25 (310) 20 (316) 21 (324) 28 (327) 28 (327) 22 (318) 20 (316) 19 (316) 46 (451) 29 (334) 48 (491) 19 (316)
bisantrene hydrochloride bisoprolol fumarate bivalirudin blonanserin boceprevir bopindolol bortezomib bosentan bosutinib brentuximab brimonidine brinzolamide brodimoprin bromfenac sodium brotizolam brovincamine fumarate bucillamine bucladesine sodium budipine budralazine bulaquine bunazosin hydrochloride bupropion hydrochloride buserelin acetate buspirone hydrochloride butenafine hydrochloride butibufen butoconazole butoctamide butyl flufenamate cabazitaxel cabergoline cabozantinib cadexomer iodine
547
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
cadralazine calcipotriol camostat mesylate canagliflozin canakinumab candesartan cilexetil capecitabine captopril carboplatin carfilzomib carperitide carumonam carvedilol caspofungin acetate catumaxomab cefbuperazone sodium cefcapene pivoxil cefdinir cefditoren pivoxil cefepime cefetamet pivoxil hydrochloride cefixime cefmenoxime hydrochloride cefminox sodium cefodizime sodium cefonicid sodium ceforanide cefoselis cefotetan disodium cefotiam hexetil hydrochloride cefozopran hydrochloride cefpimizole cefpiramide sodium cefpirome sulfate cefpodoxime proxetil cefprozil ceftaroline fosamil ceftazidime cefteram pivoxil ceftibuten ceftobiprole medocaril cefuroxime axetil
antihypertensive antipsoriasis anticancer antidiabetic antiinflammatory antihypertensive anticancer antihypertensive antibacterial anticancer congestive heart failure antibacterial antihypertensive antifungal anticancer antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial
1988 1991 1985 2013 2009 1997 1998 1982 1986 2012 1995 1988 1991 2001 2009 1985 1997 1991 1994 1993 1992
24 (298) 27 (323) 21 (325) 49 (453) 45 (484) 33 (330) 34 (319) 13 (086) 22 (318) 48 (492) 31 (339) 24 (298) 27 (323) 37 (263) 45 (486) 21 (325) 33 (330) 27 (323) 30 (297) 29 (334) 28 (327)
antibacterial antibacterial
1987 1983
23 (329) 19 (316)
antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial
1987 1990 1984 1984 1998 1984 1991
23 (330) 26 (300) 20 (316) 20 (317) 34 (319) 20 (317) 27 (324)
antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial
1995 1987 1985 1992 1989 1992 2010 1983 1987 1992 2008 1987
31 (339) 23 (330) 21 (325) 28 (328) 25 (310) 28 (328) 46 (453) 19 (316) 23 (330) 28 (329) 44 (589) 23 (331)
548
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
cefuzonam sodium celecoxib celiprolol hydrochloride centchroman centoxin cerivastatin certolizumab pegol cetilistat cetirizine hydrochloride cetrorelix cetuximab cevimeline hydrochloride chenodiol CHF-1301 choline alfoscerate choline fenofibrate cibenzoline ciclesonide cicletanine cidofovir cilazapril cilostazol cimetropium bromide cinacalcet cinildipine cinitapride cinolazepam ciprofibrate ciprofloxacin cisapride cisatracurium besilate citalopram cladribine clarithromycin clevidipine clevudine clobenoside cloconazole hydrochloride clodronate disodium clofarabine clopidogrel hydrogensulfate cloricromen clospipramine hydrochloride
antibacterial antiarthritic antihypertensive contraception immunomodulator antihypercholesterolemic irritable bowel syndrome antiobesity antiallergy infertility anticancer antixerostomia gallstones Parkinson’s disease cognition enhancer antihypercholesterolemic antiarrhythmic antiasthma antihypertensive antiviral antihypertensive antithrombotic antispasmodic hyperparathyroidism antihypertensive gastroprokinetic anxiolytic antihypercholesterolemic antibacterial gastroprokinetic muscle relaxant antidepressant anticancer antibacterial antihypertensive antiviral antiinflammatory antifungal calcium regulation anticancer antithrombotic
1987 1999 1983 1991 1991 1997 2008 2013 1987 1999 2003 2000 1983 1999 1990 2008 1985 2005 1988 1996 1990 1988 1985 2004 1995 1990 1993 1985 1986 1988 1995 1989 1993 1990 2008 2007 1988 1986 1986 2005 1998
23 (331) 35 (335) 19 (317 27 (324) 27 (325) 33 (331) 44 (592) 49 (454) 23 (331) 35 (336) 39 (272) 36 (299) 19 (317) 35 (336) 26 (300) 44 (594) 21 (325) 41 (443) 24 (299) 32 (306) 26 (301) 24 (299) 21 (326) 40 (451) 31 (339) 26 (301) 29 (334) 21 (326) 22 (318) 24 (299) 31 (340) 25 (311) 29 (335) 26 (302) 44 (596) 43 (466) 24 (300) 22 (318) 22 (319) 41 (444) 34 (320)
antithrombotic antipsychotic
1991 1991
27 (325) 27 (325)
549
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
cobicistat
INDICATION
antiviral pharmacokinetic enhancer) colesevelam hydrochloride antihypercholesterolemic colestimide antihypercholesterolemic colforsin daropate congestive heart failure hydrochloride conivaptan hyponatremia corifollitropin alfa infertility crizotinib anticancer crofelemer antidiarrheal crotelidae polyvalent antidote, snake venom poisoning immune fab cyclosporine immunosuppressant cytarabine ocfosfate anticancer dabigatran etexilate anticoagulant dabrafenib anticancer dalfampridine multiple sclerosis dalfopristin antibacterial dapagliflozin antidiabetic dapiprazole hydrochloride antiglaucoma dapoxetine premature ejaculation daptomycin antibacterial darifenacin urinary tract/bladder disorders darunavir antiviral dasatinib anticancer decitabine myelodysplastic syndromes defeiprone iron chelation therapy deferasirox iron chelation therapy defibrotide antithrombotic deflazacort antiinflammatory degarelix acetate anticancer delapril antihypertensive delavirdine mesylate antiviral denileukin diftitox anticancer denopamine congestive heart failure denosumab osteoporosis deprodone propionate antiinflammatory desflurane anesthetic desloratadine antiallergy desvenlafaxine antidepressant dexfenfluramine antiobesity dexibuprofen antiinflammatory dexlansoprazole antiulcer dexmedetomidine sleep disorders hydrochloride
YEAR ARMC VOL., INTRODUCED (PAGE)
2013
49 (456)
2000 1999 1999
36 (300) 35 (337) 35 (337)
2006 2010 2011 2012 2001
42 (514) 46 (455) 47 (525) 48 (494) 37 (263)
1983 1993 2008 2013 2010 1999 2012 1987 2009 2003 2005 2006 2006 2006 1995 2005 1986 1986 2009 1989 1997 1999 1988 2010 1992 1992 2001 2008 1997 1994 2009 2000
19 (317) 29 (335) 44 (598) 49 (458) 46 (458) 35 (338) 48 (495) 23 (332) 45 (488) 39 (272) 41 (445) 42 (515) 42 (517) 42 (519) 31 (340) 41 (446) 22 (319) 22 (319) 45 (490) 25 (311) 33 (331) 35 (338) 24 (300) 46 (459) 28 (329) 28 (329) 37 (264) 44 (600) 33 (332) 30 (298) 45 (492) 36 (301)
550
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
dexmethylphenidate hydrochloride dexrazoxane dezocine diacerein didanosine dilevalol dimethyl fumarate diquafosol tetrasodium dirithromycin disodium pamidronate divistyramine docarpamine docetaxel dofetilide dolasetron mesylate dolutegravir donepezil hydrochloride dopexamine doripenem dornase alfa dorzolamide hydrochloride dosmalfate doxacurium chloride doxazosin mesylate doxefazepam doxercalciferol doxifluridine doxofylline dronabinol dronedarone drospirenone drotrecogin alfa droxicam droxidopa duloxetine dutasteride duteplase ebastine eberconazole ebrotidine ecabet sodium ecallantide eculizumab
attention deficit hyperactivity disorder cardioprotective analgesic antiinflammatory antiviral antihypertensive multiple sclerosis ophthalmologic (dry eye) antibacterial osteoporosis antihypercholesterolemic congestive heart failure anticancer antiarrhythmic antiemetic antiviral Alzheimer’s disease congestive heart failure antibacterial cystic fibrosis antiglaucoma
2002
38 (352)
1992 1991 1985 1991 1989 2013 2010 1993 1989 1984 1994 1995 2000 1998 2013 1997 1989 2005 1994 1995
28 27 21 27 25 49 46 29 25 20 30 31 36 34 49 33 25 41 30 31
(330) (326) (326) (326) (311) (460) (462) (336) (312) (317) (298) (341) (301) (321) (461) (332) (312) (448) (298) (341)
antiulcer muscle relaxant antihypertensive anxiolytic hyperparathyroidism anticancer antiasthma antiemetic antiarrhythmic contraception antisepsis antiinflammatory Parkinson’s disease antidepressant benign prostatic hyperplasia anticoagulant antiallergy antifungal antiulcer antiulcer angioedema, hereditary hemoglobinuria
2000 1991 1988 1985 1999 1987 1985 1986 2009 2000 2001 1990 1989 2004 2002 1995 1990 2005 1997 1993 2009 2007
36 27 24 21 35 23 21 22 45 36 37 26 25 40 38 31 26 41 33 29 46 43
(302) (326) (300) (326) (339) (332) (327) (319) (495) (302) (265) (302) (312) (452) (353) (342) (302) (449) (333) (336) (464) (468)
551
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
edaravone edoxaban efalizumab efavirenz efinaconazole efonidipine egualen sodium eldecalcitol eletriptan eltrombopag elvitegravir emedastine difumarate emorfazone emtricitabine enalapril maleate enalaprilat encainide hydrochloride enfuvirtide enocitabine enoxacin enoxaparin enoximone enprostil entacapone entecavir enzalutamide epalrestat eperisone hydrochloride epidermal growth factor epinastine epirubicin hydrochloride eplerenone epoprostenol sodium eprosartan eptazocine hydrobromide eptilfibatide erdosteine eribulin mesylate erlotinib ertapenem sodium erythromycin acistrate erythropoietin escitalopram oxolate eslicarbazepine acetate esmolol hydrochloride
neuroprotective antithrombotic antipsoriasis antiviral antifungal antihypertensive antiulcer osteoporosis antimigraine antithrombocytopenic antiviral antiallergy analgesic antiviral antihypertensive antihypertensive antiarrhythmic antiviral anticancer antibacterial anticoagulant congestive heart failure antiulcer Parkinson’s disease antiviral anticancer antidiabetic muscle relaxant wound healing agent antiallergy anticancer antihypertensive antiplatelet antihypertensive analgesic antithrombotic expectorant anticancer anticancer antibacterial antibacterial hematopoietic antidepressant anticonvulsant antiarrhythmic
2001 2011 2003 1998 2013 1994 2000 2011 2001 2009 2013 1993 1984 2003 1984 1987 1987 2003 1983 1986 1987 1988 1985 1998 2005 2012 1992 1983 1987 1994 1984 2003 1983 1997 1987 1999 1995 2010 2004 2002 1988 1988 2002 2009 1987
37 (265) 47 (527) 39 (274) 34 (321) 49 (463) 30 (299) 36 (303) 47 (529) 37 (266) 45 (497) 49 (465) 29 (336) 20 (317) 39 (274) 20 (317) 23 (332) 23 (333) 39 (275) 19 (318) 22 (320) 23 (333) 24 (301) 21 (327) 34 (322) 41 (450) 48 (497) 28 (330) 19 (318) 23 (333) 30 (299) 20 (318) 39 (276) 19 (318) 33 (333) 23 (334) 35 (340) 31 (342) 46 (465) 40 (454) 38 (353) 24 (301) 24 (301) 38 (354) 45 (498) 23 (334)
552
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
esomeprazole magnesium eszopiclone ethyl icosapentate etizolam etodolac etoricoxibe etravirine everolimus exemestane exenatide exifone ezetimibe factor VIIa factor VIII fadrozole hydrochloride falecalcitriol famciclovir famotidine fasudil hydrochloride febuxostat felbamate felbinac felodipine fenbuprol fenoldopam mesylate fenticonazole nitrate fesoterodine fexofenadine fidaxomicin filgrastim finasteride fingolimod fisalamine fleroxacin flomoxef sodium flosequinan fluconazole fludarabine phosphate flumazenil
antiulcer sleep disorders antithrombotic anxiolytic antiinflammatory antiarthritic antiviral immunosuppressant anticancer antidiabetic cognition enhancer antihypercholesterolemic haemophilia hemostatic anticancer hyperparathyroidism antiviral antiulcer amyotrophic lateral sclerosis gout anticonvulsant antiinflammatory antihypertensive biliary tract dysfunction antihypertensive antifungal urinary tract/bladder disorders antiallergy antibacterial immunostimulant benign prostatic hyperplasia multiple sclerosis antiinflammatory antibacterial antibacterial congestive heart failure antifungal anticancer antidote, benzodiazepine overdose antiinflammatory antidepressant analgesic antibacterial
2000 2005 1990 1984 1985 2002 2008 2004 2000 2005 1988 2002 1996 1992 1995 2001 1994 1985 1995 2009 1993 1986 1988 1983 1998 1987 2008 1996 2011 1991 1992 2010 1984 1992 1988 1992 1988 1991 1987
36 (303) 41 (451) 26 (303) 20 (318) 21 (327) 38 (355) 44 (602) 40 (455) 36 (304) 41 (452) 24 (302) 38 (355) 32 (307) 28 (330) 31 (342) 37 (266) 30 (300) 21 (327) 31 (343) 45 (501) 29 (337) 22 (320) 24 (302) 19 (318) 34 (322) 23 (334) 44 (604) 32 (307) 47 (531) 27 (327) 28 (331) 46 (468) 20 (318) 28 (331) 24 (302) 28 (331) 24 (303) 27 (327) 23 (335)
1987 1986 1985 1997
23 22 21 33
flunoxaprofen fluoxetine hydrochloride flupirtine maleate flurithromycin ethylsuccinate
(335) (320) (328) (333)
553
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
flutamide flutazolam fluticasone furoate fluticasone propionate flutoprazepam flutrimazole flutropium bromide fluvastatin fluvoxamine maleate follitropin alfa follitropin beta fomepizole
INDICATION
anticancer anxiolytic antiallergy antiinflammatory anxiolytic antifungal antiasthma antihypercholesterolemic antidepressant infertility infertility antidote, ethylene glycol poisoning fomivirsen sodium antiviral fondaparinux sodium antithrombotic formestane anticancer formoterol fumarate chronic obstructive pulmonary disorder fosamprenavir antiviral fosaprepitant dimeglumine antiemetic foscarnet sodium antiviral fosfluconazole antifungal fosfosal analgesic fosinopril sodium antihypertensive fosphenytoin sodium anticonvulsant fotemustine anticancer fropenam antibacterial frovatriptan antimigraine fudosteine expectorant fulveristrant anticancer gabapentin anticonvulsant gabapentin Enacarbil restless leg syndrome gadoversetamide diagnostic gallium nitrate calcium regulation gallopamil hydrochloride antianginal galsulfase mucopolysaccharidosis VI ganciclovir antiviral ganirelix acetate infertility garenoxacin antibacterial gatilfloxacin antibacterial gefitinib anticancer gemcitabine hydrochloride anticancer gemeprost abortifacient gemifloxacin antibacterial gemtuzumab ozogamicin anticancer
YEAR ARMC VOL., INTRODUCED (PAGE)
1983 1984 2007 1990 1986 1995 1988 1994 1983 1996 1996 1998
19 (318) 20 (318) 43 (469) 26 (303) 22 (320) 31 (343) 24 (303) 30 (300) 19 (319) 32 (307) 32 (308) 34 (323)
1998 2002 1993 1986
34 (323) 38 (356) 29 (337) 22 (321)
2003 2008 1989 2004 1984 1991 1996 1989 1997 2002 2001 2002 1993 2011 2000 1991 1983 2005 1988 2000 2007 1999 2002 1995 1983 2004 2000
39 (277) 44 (606) 25 (313) 40 (457) 20 (319) 27 (328) 32 (308) 25 (313) 33 (334) 38 (357) 37 (267) 38 (357) 29 (338) 47 (533) 36 (304) 27 (328) 19 (3190) 41 (453) 24 (303) 36 (305) 43 (471) 35 (340) 38 (358) 31 (344) 19 (319) 40 (458) 36 (306)
554
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
gestodene gestrinone glatiramer acetate glimepiride glucagon, rDNA GMDP golimumab goserelin granisetron hydrochloride guanadrel sulfate gusperimus halobetasol propionate halofantrine halometasone histrelin hydrocortisone aceponate hydrocortisone butyrate ibandronic acid ibopamine hydrochloride ibritunomab tiuxetan ibrutinib ibudilast ibutilide fumarate icatibant idarubicin hydrochloride idebenone idursulfase
contraception contraception multiple sclerosis antidiabetic antidiabetic immunostimulant antiinflammatory hormone therapy antiemetic antihypertensive immunosuppressant antiinflammatory antimalarial antiinflammatory precocious puberty antiinflammatory antiinflammatory osteoporosis congestive heart failure anticancer anticancer antiasthma antiarrhythmic angioedema, hereditary anticancer nootropic mucopolysaccharidosis II (Hunter syndrome) antiarthritic antiplatelet anticancer urinary tract/bladder disorders antihypertensive Gaucher’s disease antibacterial antiviral osteoporosis chronic obstructive pulmonary disease antidepressant nootropic
1987 1986 1997 1995 1993 1996 2009 1987 1991 1983 1994 1991 1988 1983 1993 1988 1983 1996 1984 2002 2013 1989 1996 2008 1990 1986 2006
23 (335) 22 (321) 33 (334) 31 (344) 29 (338) 32 (308) 45 (503) 23 (336) 27 (329) 19 (319) 30 (300) 27 (329) 24 (304) 19 (320) 29 (338) 24 (304) 19 (320) 32 (309) 20 (319) 38 (359) 49 (466) 25 (313) 32 (309) 44 (608) 26 (303) 22 (321) 42 (520)
2011 1992 2001 2007 1993 1994 1985 1997 1997 2009
47 28 37 43 29 30 21 33 33 45
1983 1988
19 (320) 24 (304)
antiviral antiemetic antithrombotic
1996 2004 1984
32 (310) 40 (459) 20 (319)
iguratimod iloprost imatinib mesylate imidafenacin imidapril hydrochloride imiglucerase imipenem/cilastatin imiquimod incadronic acid indacaterol indalpine indeloxazine hydrochloride indinavir sulfate indisetron indobufen
(535) (332) (267) (472) (339) (301) (328) (335) (335) (505)
555
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
influenza virus (live) ingenol mebutate insulin lispro interferon alfacon-1 interferon gamma-1b interferon, b-1a interferon, b-1b interferon, gamma interferon, gamma-1 interleukin-2 ioflupane ipilimumab ipriflavone irbesartan irinotecan irsogladine isepamicin isofezolac isoxicam isradipine istradefylline itopride hydrochloride itraconazole ivabradine ivacaftor ivermectin ixabepilone ketanserin ketorolac tromethamine kinetin
antiviral anticancer antidiabetic antiviral immunostimulant multiple sclerosis multiple sclerosis antiinflammatory anticancer anticancer diagnostic anticancer osteoporosis antihypertensive anticancer antiulcer antibacterial antiinflammatory antiinflammatory antihypertensive Parkinson’s disease gastroprokinetic antifungal antianginal cystic fibrosis antiparasitic anticancer antihypertensive analgesic dermatologic, skin photodamage antihypertensive anticonvulsant antiulcer antiviral anticonvulsant antiarrhythmic antiviral antifungal growth disorders antiulcer anticancer mucopolysaccharidosis I antiglaucoma antiarthritic
2003 2012 1996 1997 1991 1996 1993 1989 1992 1989 2000 2011 1989 1997 1994 1989 1988 1984 1983 1989 2013 1995 1988 2006 2012 1987 2007 1985 1990 1999
39 (277) 48 (499) 32 (310) 33 (336) 27 (329) 32 (311) 29 (339) 25 (314) 28 (332) 25 (314) 36 (306) 47 (537) 25 (314) 33 (336) 30 (301) 25 (315) 24 (305) 20 (319) 19 (320) 25 (315) 49 (468) 31 (344) 24 (305) 42 (522) 48 (501) 23 (336) 43 (473) 21 (328) 26 (304) 35 (341)
1991 2008 2000 1995 1990 2002 2010 1994 1995 1992 2007 2003 1996 1998
27 (330) 44 (610) 36 (307) 31 (345) 26 (304) 38 (360) 46 (470) 30 (302) 31 (345) 28 (332) 43 (475) 39 (278) 32 (311) 34 (324)
lacidipine lacosamide lafutidine lamivudine lamotrigine landiolol laninamivir octanoate lanoconazole lanreotide acetate lansoprazole lapatinib laronidase latanoprost lefunomide
556
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
lenalidomide
myelodysplastic syndromes, multiple myeloma antibacterial
2006
42 (523)
1987
23 (336)
immunostimulant anticoagulant antihypertensive anticancer hormone therapy cognition enhancer
1986 1997 1997 1996 1984 1986
22 33 33 32 20 22
(322) (336) (337) (311) (319) (322)
antiasthma anticonvulsant antiglaucoma anesthetic
1999 2000 1985 2000
35 36 21 36
(341) (307) (328) (308)
antiallergy
1991
27 (330)
2001 1988 1993 2000 1984 1988 2012 2011 2000 2009 2000 2007
37 24 29 36 20 24 48 47 36 45 36 43
(268) (305) (340) (308) (320) (306) (502) (540) (309) (507) (309) (477)
1987 2013 1986 1992 1989 1999 2012 1987 2000 1983 1996 1992 1988 2012
23 49 22 28 25 35 48 23 36 19 32 28 24 48
(337) (470) (322) (333) (315) (342) (504) (337) (310) (321) (312) (333) (306) (506)
lenampicillin hydrochloride lentinan lepirudin lercanidipine letrazole leuprolide acetate levacecarnine hydrochloride levalbuterol hydrochloride levetiracetam levobunolol hydrochloride levobupivacaine hydrochloride levocabastine hydrochloride levocetirizine levodropropizine levofloxacin levosimendan lidamidine hydrochloride limaprost linaclotide linagliptin linezolid liraglutide liranaftate lisdexamfetamine
antiallergy antitussive antibacterial congestive heart failure antidiarrheal antithrombotic irritable bowel syndrome antidiabetic antibacterial antidiabetic antifungal attention deficit hyperactivity disorder lisinopril antihypertensive lixisenatide antidiabetic lobenzarit sodium antiinflammatory lodoxamide tromethamine antiallergy lomefloxacin antibacterial lomerizine hydrochloride antimigraine lomitapide antihypercholersteremic lonidamine anticancer lopinavir antiviral loprazolam mesylate sleep disorders loprinone hydrochloride congestive heart failure loracarbef antibacterial loratadine antiallergy lorcaserin hydrochloride antiobesity
557
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
lornoxicam losartan loteprednol etabonate lovastatin loxoprofen sodium lulbiprostone luliconazole lumiracoxib lurasidone hydrochloride Lyme disease vaccine mabuterol hydrochloride macitentan malotilate manidipine hydrochloride maraviroc masoprocol maxacalcitol mebefradil hydrochloride medifoxamine fumarate mefloquine hydrochloride meglutol melinamide meloxicam mepixanox meptazinol hydrochloride meropenem metaclazepam metapramine methylnaltrexone bromide metreleptin mexazolam micafungin mifamurtide mifepristone miglitol miglustat milnacipran milrinone miltefosine minodronic acid miokamycin mipomersen mirabegron mirtazapine misoprostol
antiinflammatory antihypertensive antiallergy antihypercholesterolemic antiinflammatory constipation antifungal antiinflammatory antipsychotic Lyme disease antiasthma pulmonary hypertension hepatoprotective antihypertensive antiviral anticancer hyperparathyroidism antihypertensive antidepressant antimalarial antihypercholesterolemic antihypercholesterolemic antiarthritic respiratory stimulant analgesic antibacterial anxiolytic antidepressant constipation lipodystrophy anxiolytic antifungal anticancer abortifacient antidiabetic Gaucher’s disease antidepressant congestive heart failure anticancer osteoporosis antibacterial antihypercholesterolemic urinary tract/bladder disorders antidepressant antiulcer
1997 1994 1998 1987 1986 2006 2005 2005 2010 1999 1986 2013 1985 1990 2007 1992 2000 1997 1986 1985 1983 1984 1996 1984 1983 1994 1987 1984 2008 2013 1984 2002 2009 1988 1998 2003 1997 1989 1993 2009 1985 2013 2011 1994 1985
33 (337) 30 (302) 34 (324) 23 (337) 22 (322) 42 (525) 41 (454) 41 (455) 46 (473) 35 (342) 22 (323) 49 (472) 21 (329) 26 (304) 43 (478) 28 (333) 36 (310) 33 (338) 22 (323) 21 (329) 19 (321) 20 (320) 32 (312) 20 (320) 19 (321) 30 (303) 23 (338) 20 (320) 44 (612) 49 (474) 20 (321) 38 (360) 46 (476) 24 (306) 34 (325) 39 (279) 33 (338) 25 (316) 29 (340) 45 (509) 21 (329) 49 (476) 47 (542) 30 (303) 21 (329)
558
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
mitiglinide mitoxantrone hydrochloride mivacurium chloride mivotilate mizolastine mizoribine moclobemide modafinil moexipril hydrochloride mofezolac mogamulizumab mometasone furoate montelukast sodium moricizine hydrochloride mosapride citrate moxifloxacin hydrochloride moxonidine mozavaptan mupirocin muromonab-CD3 muzolimine mycophenolate mofetil mycophenolate sodium nabumetone nadifloxacin nafamostat mesylate nafarelin acetate naftifine hydrochloride naftopidil nalfurafine hydrochloride nalmefene hydrochloride naltrexone hydrochloride naratriptan hydrochloride nartograstim natalizumab nateglinide nazasetron nebivolol nedaplatin nedocromil sodium nefazodone nelarabine nelfinavir mesylate
antidiabetic anticancer
2004 1984
40 (460) 20 (321)
muscle relaxant hepatoprotective antiallergy immunosuppressant antidepressant sleep disorders antihypertensive analgesic anticancer antiinflammatory antiasthma antiarrhythmic gastroprokinetic antibacterial
1992 1999 1998 1984 1990 1994 1995 1994 2012 1987 1998 1990 1998 1999
28 35 34 20 26 30 31 30 48 23 34 26 34 35
antihypertensive hyponatremia antibacterial immunosuppressant diuretic immunosuppressant immunosuppressant antiinflammatory antibacterial pancreatitis hormone therapy antifungal urinary tract/bladder disorders pruritus addiction, opioids addiction, opioids antimigraine leukopenia multiple sclerosis antidiabetic antiemetic antihypertensive anticancer antiallergy antidepressant anticancer antiviral
1991 2006 1985 1986 1983 1995 2003 1985 1993 1986 1990 1984 1999 2009 1995 1984 1997 1994 2004 1999 1994 1997 1995 1986 1994 2006 1997
27 (330) 42 (527) 21 (330) 22 (323) 19 (321) 31 (346) 39 (279) 21 (330) 29 (340) 22 (323) 26 (306) 20 (321) 35 (344) 45 (510) 31 (347) 20 (322) 33 (339) 30 (304) 40 (462) 35 (344) 30 (305) 33 (339) 31 (347) 22 (324) 30 (305) 42 (528) 33 (340)
(334) (343) (325) (321) (305) (303) (346) (304) (507) (338) (326) (305) (326) (343)
559
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
neltenexine nemonapride nepafenac neridronic acide nesiritide neticonazole hydrochloride nevirapine nicorandil nif ekalant hydrochloride nilotinib nilutamide nilvadipine nimesulide nimodipine nimotuzumab nipradilol nisoldipine nitisinone nitrefazole nitrendipine nizatidine nizofenzone nomegestrol acetate norelgestromin norfloxacin norgestimate obinutuzumab OCT-43 octreotide ofatumumab ofloxacin olanzapine olimesartan Medoxomil olodaterol
cystic fibrosis antipsychotic antiinflammatory calcium regulation congestive heart failure antifungal
1993 1991 2005 2002 2001 1993
29 (341) 27 (331) 41 (456) 38 (361) 37 (269) 29 (341)
1996 1984 1999 2007 1987 1989 1985 1985 2006 1988 1990 2002 1983 1985 1987 1988 1986 2002 1983 1986 2013 1999 1988 2009 1985 1996 2002 2013
32 (313) 20 (322) 35 (344) 43 (480) 23 (338) 25 (316) 21 (330) 21 (330) 42 (529) 24 (307) 26 (306) 38 (361) 19 (322) 21 (331) 23 (339) 24 (307) 22 (324) 38 (362) 19 (322) 22 (324) 49 (478) 35 (345) 24 (307) 45 (512) 21 (331) 32 (313) 38 (363) 49 (480)
1997 2012
33 (340) 48 (510)
2003 1988 1990
39 (280) 24 (308) 26 (306)
2001 1998
37 (269) 34 (327)
antiviral antianginal antiarrhythmic anticancer anticancer antihypertensive antiinflammatory cerebral vasodilator anticancer antihypertensive antihypertensive antityrosinaemia addiction, alcohol antihypertensive antiulcer nootropic contraception contraception antibacterial contraception anticancer anticancer growth disorders anticancer antibacterial antipsychotic antihypertensive chronic obstructive pulmonary disorder olopatadine hydrochloride antiallergy omacetaxine anticancer mepesuccinate omalizumab allergic antiasthma omeprazole antiulcer ondansetron antiemetic hydrochloride OP-1 osteoinductor orlistat antiobesity
560
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
ornoprostil osalazine sodium oseltamivir phosphate ospemifene oxaliplatin oxaprozin oxcarbazepine oxiconazole nitrate oxiracetam oxitropium bromide ozagrel sodium paclitaxal palifermin paliperidone palonosetron panipenem/ betamipron carbapenem panitumumab pantoprazole sodium parecoxib sodium paricalcitol parnaparin sodium paroxetine pasireotide pazopanib pazufloxacin pefloxacin mesylate pegademase bovine pegaptanib
antiulcer antiinflammatory antiviral dyspareunia anticancer antiinflammatory anticonvulsant antifungal cognition enhancer antiasthma antithrombotic anticancer mucositis antipsychotic antiemetic antibacterial
1987 1986 1999 2013 1996 1983 1990 1983 1987 1983 1988 1993 2005 2007 2003 1994
23 (339) 22 (324) 35 (346) 49 (482) 32 (313) 19 (322) 26 (307) 19 (322) 23 (339) 19 (323) 24 (308) 29 (342) 41 (461) 43 (482) 39 (281) 30 (305)
2006 1995 2002 1998 1993 1991 2012 2009 2002 1985 1990 2005
42 30 38 34 29 27 48 45 38 21 26 41
1994 2012 2003 2004 1991 1996 1992 2010 2012 1988 1988 2001 2012 1987 1993
30 (306) 48 (514) 39 (281) 40 (463) 27 (331) 32 (314) 28 (334) 46 (477) 48 (516) 24 (308) 24 (309) 37 (270) 48 (517) 23 (340) 29 (343)
anticancer antiulcer analgesic hyperparathyroidism anticoagulant antidepressant Cushing’s Disease anticancer antibacterial antibacterial immunostimulant ophthalmologic (macular degeneration) pegaspargase anticancer peginesatide acetate hematopoietic pegvisomant growth disorders pemetrexed anticancer pemirolast potassium antiasthma penciclovir antiviral pentostatin anticancer peramivir antiviral perampanel anticonvulsant pergolide mesylate Parkinson’s disease perindopril antihypertensive perospirone hydrochloride antipsychotic pertuzumab anticancer picotamide antithrombotic pidotimod immunostimulant
(531) (306) (364) (327) (342) (331) (512) (514) (364) (331) (307) (458)
561
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
piketoprofen pilsicainide hydrochloride pimaprofen pimecrolimus pimobendan pinacidil pioglitazone hydrochloride pirarubicin pirfenidone pirmenol piroxicam cinnamate pitavastatin pivagabine pixantrone dimaleate plaunotol plerixafor hydrochloride polaprezinc pomalidomide ponatinib porfimer sodium posaconazole pralatrexate pramipexole hydrochloride pramiracetam sulfate pramlintide pranlukast prasugrel pravastatin prednicarbate pregabalin prezatide copper acetate progabide promegestrone propacetamol hydrochloride propagermanium propentofylline propionate propiverine hydrochloride propofol prulifloxacin pumactant quazepam quetiapine fumarate quinagolide
antiinflammatory antiarrhythmic antiinflammatory immunosuppressant congestive heart failure antihypertensive antidiabetic anticancer pulmonary fibrosis, idiopathic antiarrhythmic antiinflammatory antihypercholesterolemic antidepressant anticancer antiulcer stem cell mobilizer antiulcer anticancer anticancer anticancer antifungal anticancer Parkinson’s disease
1984 1991 1984 2002 1994 1987 1999 1988 2008 1994 1988 2003 1997 2012 1987 2009 1994 2013 2012 1993 2006 2009 1997
20 (322) 27 (332) 20 (322) 38 (365) 30 (307) 23 (340) 35 (346) 24 (309) 44 (614) 30 (307) 24 (309) 39 (282) 33 (341) 48 (519) 23 (340) 45 (515) 30 (307) 49 (484) 48 (521) 29 (343) 42 (532) 45 (517) 33 (341)
cognition enhancer antidiabetic antiasthma antiplatelet antihypercholesterolemic antiinflammatory anticonvulsant wound healing agent anticonvulsant contraception analgesic
1993 2005 1995 2009 1989 1986 2004 1996 1985 1983 1986
29 (343) 41 (460) 31 (347) 45 (519) 25 (316) 22 (325) 40 (464) 32 (314) 21 (331) 19 (323) 22 (325)
antiviral cerebral vasodilator urinary tract/bladder disorders anesthetic antibacterial respiratory distress syndrome sleep disorders antipsychotic hyperprolactinemia
1994 1988 1992 1986 2002 1994 1985 1997 1994
30 (308) 24 (310) 28 (335) 22 (325) 38 (366) 30 (308) 21 (332) 33 (341) 30 (309)
562
GENERIC NAME
quinapril quinf amideamebicide quinupristin rabeprazole sodium radotinib raloxifene hydrochloride raltegravir raltitrexed ramatroban ramelteon ramipril ramosetron ranibizumab
Cumulative NCE Introduction Index, 1983–2013
INDICATION
antihypertensive antiparasitic antibacterial antiulcer anticancer osteoporosis antiviral anticancer antiallergy sleep disorders antihypertensive antiemetic ophthalmologic (macular degeneration) ranimustine anticancer ranitidine bismuth citrate antiulcer ranolazine antianginal rapacuronium bromide muscle relaxant rasagiline Parkinson’s disease rebamipide antiulcer reboxetine antidepressant regorafenib anticancer remifentanil hydrochloride analgesic remoxipride antipsychotic hydrochloride repaglinide antidiabetic repirinast antiallergy retapamulin antibacterial reteplase antithrombotic retigabine anticonvulsant reviparin sodium anticoagulant rifabutin antibacterial rifapentine antibacterial rifaximin antibacterial rifaximin antibacterial rilmazafone sleep disorders rilmenidine antihypertensive rilonacept genetic autoinflammatory syndromes rilpivirine antiviral riluzole amyotrophic lateral sclerosis rimantadine hydrochloride antiviral rimexolone antiinflammatory rimonabant antiobesity riociguat pulmonary hypertension
YEAR ARMC VOL., INTRODUCED (PAGE)
1989 1984 1999 1998 2012 1998 2007 1996 2000 2005 1989 1996 2006
25 (317) 20 (322) 35 (338) 34 (328) 48 (523) 34 (328) 43 (484) 32 (315) 36 (311) 41 (462) 25 (317) 32 (315) 42 (534)
1987 1995 2006 1999 2005 1990 1997 2012 1996 1990
23 31 42 35 41 26 33 48 32 26
(341) (348) (535) (347) (464) (308) (342) (524) (316) (308)
1998 1987 2007 1996 2011 1993 1992 1988 1987 1985 1989 1988 2008
34 23 43 32 47 29 28 24 23 21 25 24 44
(329) (341) (486) (316) (544) (344) (335) (310) (341) (332) (317) (310) (615)
2011 1996 1987 1995 2006 2013
47 32 23 31 42 49
(546) (316) (342) (348) (537) (486)
563
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
risedronate sodium risperidone ritonavir rivaroxaban rivastigmin rizatriptan benzoate rocuronium bromide rofecoxib roflumilast
osteoporosis antipsychotic antiviral anticoagulant Alzheimer’s disease antimigraine muscle relaxant antiarthritic chronic obstructive pulmonary disorder antibacterial anticancer antithrombocytopenic immunostimulant antihypercholesterolemic Parkinson’s disease anesthetic antiulcer antidiabetic antihypercholesterolemic Parkinson’s disease antiulcer
1998 1993 1996 2008 1997 1998 1994 1999 2010
34 (330) 29 (344) 32 (317) 44 (617) 33 (342) 34 (330) 30 (309) 35 (347) 46 (480)
1986 2009 2008 1991 1986 1996 1996 1985 1999 2003 2006 1986
22 (325) 46 (482) 44 (619) 27 (332) 22 (326) 32 (317) 32 (318) 21 (332) 35 (348) 39 (283) 42 (538) 22 (326)
antiulcer anticonvulsant antibacterial antiallergy anticancer antibacterial antiasthma
1987 2007 1992 2003 2011 1989 1990
23 (342) 43 (488) 28 (335) 39 (284) 47 (548) 25 (318) 26 (308)
phenylketouria antiviral immunostimulant antidiabetic antithrombotic antidiabetic immunostimulant antiasthma antifungal antipsychotic antiallergy antidepressant antidepressant anesthetic
1992 1995 1991 2013 1993 2009 1985 1995 1992 1996 1987 1989 1990 1990
28 (336) 31 (349) 27 (332) 49 (488) 29 (344) 45 (521) 22 (326) 31 (349) 28 (336) 32 (318) 23 (342) 25 (318) 26 (309) 26 (309)
rokitamycin romidepsin romiplostim romurtide ronafibrate ropinirole hydrochloride ropivacaine rosaprostol rosiglitazone maleate rosuvastatin rotigotine roxatidine acetate hydrochloride roxithromycin rufinamide rufloxacin hydrochloride rupatadine fumarate ruxolitinib RV-11 salmeterol hydroxynaphthoate sapropterin hydrochloride saquinavir mesvlate sargramostim saroglitazar sarpogrelate hydrochloride saxagliptin schizophyllan seratrodast sertaconazole nitrate sertindole setastine hydrochloride setiptiline setraline hydrochloride sevoflurane
564
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
sibutramine sildenafil citrate silodosin simeprevir simvastatin sipuleucel-t sitafloxacin hydrate sitagliptin sitaxsentan sivelestat SKI-2053R sobuzoxane sodium cellulose phosphate sofalcone sofosbuvir solifenacin somatomedin-1 somatotropin somatropin sorafenib sorivudine sparfloxacin spirapril hydrochloride spizofurone stavudine strontium ranelate succimer sufentanil sugammadex
antiobesity male sexual dysfunction urinary tract/bladder disorders antiviral antihypercholesterolemic anticancer antibacterial antidiabetic pulmonary hypertension antiinflammatory anticancer anticancer urinary tract/bladder disorders antiulcer antiviral urinary tract/bladder disorders growth disorders growth disorders growth disorders anticancer antiviral antibacterial antihypertensive antiulcer antiviral osteoporosis antidote, lead poisoning analgesic neuromuscular blockade, reversal antibacterial antifungal antibacterial antimigraine anticancer antiallergy analgesic respiratory surfactant antipsoriasis Alzheimer’s disease immunosuppressant male sexual dysfunction neurodegeneration antiglaucoma anticancer
1998 1998 2006 2013 1988 2010 2008 2006 2006 2002 1999 1994 1983 1984 2013 2004 1994 1994 1987 2005 1993 1993 1995 1987 1994 2004 1991 1983 2008
34 (331) 34 (331) 42 (540) 49 (489) 24 (311) 46 (484) 44 (621) 42 (541) 42 (543) 38 (366) 35 (348) 30 (310) 19 (323) 20 (323) 49 (492) 40 (466) 30 (310) 30 (310) 23 (343) 41 (466) 29 (345) 29 (345) 31 (349) 23 (343) 30 (311) 40 (466) 27 (333) 19 (323) 44 (623)
1986 1985 1987 1991 2006 1995 1983 1987 1993 1993 1993 2003 2011 2008 2004
22 21 23 27 42 31 19 23 29 29 29 39 47 44 40
sulbactam sodium sulconizole nitrate sultamycillin tosylate sumatriptan succinate sunitinib suplatast tosilate suprofen surfactant TA tacalcitol tacrine hydrochloride tacrolimus tadalafil tafamidis tafluprost talaporfin sodium
(326) (332) (343) (333) (544) (350) (324) (344) (346) (346) (347) (284) (550) (625) (469)
565
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
talipexole taltirelin tamibarotene tamsulosin hydrochloride tandospirone tapentadol hydrochloride tasonermin tazanolast tazarotene tazobactam sodium teduglutide tegaserod maleate teicoplanin telaprevir telavancin telbivudine telithromycin telmesteine telmisartan temafloxacin hydrochloride temocapril temocillin disodium temoporphin temozolomide temsirolimus teneligliptin tenofovir disoproxil fumarate tenoxicam teprenone terazosin hydrochloride terbinafine hydrochloride terconazole teriflunomide tertatolol hydrochloride tesamorelin acetate thrombin alfa thrombomodulin (recombinant) thymopentin tiagabine tiamenidine hydrochloride tianeptine sodium tibolone
Parkinson’s disease neurodegeneration anticancer benign prostatic hyperplasia anxiolytic analgesic anticancer antiallergy antipsoriasis antibacterial short bowel syndrome irritable bowel syndrome antibacterial antiviral antibacterial antiviral antibacterial expectorant antihypertensive antibacterial
1996 2000 2005 1993 1996 2009 1999 1990 1997 1992 2012 2001 1988 2011 2009 2006 2001 1992 1999 1991
32 (318) 36 (311) 41 (467) 29 (347) 32 (319) 45 (523) 35 (349) 26 (309) 33 (343) 28 (336) 48 (526) 37 (270) 24 (311) 47 (552) 45 (525) 42 (546) 37 (271) 28 (337) 35 (349) 27 (334)
antihypertensive antibacterial anticancer anticancer anticancer antidiabetic antiviral
1994 1984 2002 1999 2007 2012 2001
30 (311) 20 (323) 38 (367) 35 (349) 43 (490) 48 (528) 37 (271)
antiinflammatory antiulcer antihypertensive antifungal antifungal multiple sclerosis antihypertensive lipodystrophy hemostatic anticoagulant
1987 1984 1984 1991 1983 2012 1987 2010 2008 2008
23 (344) 20 (323) 20 (323) 27 (334) 19 (324) 48 (530) 23 (344) 46 (486) 44 (627) 44 (628)
immunomodulator anticonvulsant antihypertensive antidepressant hormone therapy
1985 1996 1988 1983 1988
21 (333) 32 (319) 24 (311) 19 (324) 24 (312)
566
GENERIC NAME
ticagrelor tigecycline tilisolol hydrochloride tiludronate disodium timiperone tinazoline tioconazole tiopronin tiotropium bromide
Cumulative NCE Introduction Index, 1983–2013
INDICATION
antithrombotic antibacterial antihypertensive Paget’s disease antipsychotic nasal decongestant antifungal urolithiasis chronic obstructive pulmonary disorder tipranavir antiviral tiquizium bromide antispasmodic tiracizine hydrochloride antiarrhythmic tirilazad mesylate subarachnoid hemorrhage tirofiban hydrochloride antithrombotic tiropramide hydrochloride muscle relaxant tizanidine muscle relaxant tofacitinib antiarthritic tolcapone Parkinson’s disease toloxatone antidepressant tolrestat antidiabetic tolvaptan hyponatremia topiramate anticonvulsant topotecan hydrochloride anticancer torasemide diuretic toremifene anticancer tositumomab anticancer tosufloxacin tosylate antibacterial trabectedin anticancer trametinib anticancer trandolapril antihypertensive travoprost antiglaucoma treprostinil sodium antihypertensive tretinoin tocoferil antiulcer trientine hydrochloride antidote, copper poisoning trimazosin hydrochloride antihypertensive trimegestone contraception trimetrexate glucuronate antifungal troglitazone antidiabetic tropisetron antiemetic trovafloxacin mesylate antibacterial troxipide antiulcer ubenimex immunostimulant
YEAR ARMC VOL., INTRODUCED (PAGE)
2010 2005 1992 1995 1984 1988 1983 1989 2002
46 41 28 31 20 24 19 25 38
(488) (468) (337) (350) (323) (312) (324) (318) (368)
2005 1984 1990 1995 1998 1983 1984 2012 1997 1984 1989 2009 1995 1996 1993 1989 2003 1990 2007 2013 1993 2001 2002 1993 1986 1985 2001 1994 1997 1992 1998 1986 1987
41 (470) 20 (324) 26 (310) 31 (351) 34 (332) 19 (324) 20 (324) 48 (532) 33 (343) 20 (324) 25 (319) 45 (528) 31 (351) 32 (320) 29 (348) 25 (319) 39 (285) 26 (310) 43 (492) 49 (494) 29 (348) 37 (272) 38 (368) 29 (348) 22 (327) 21 (333) 37 (273) 30 (312) 33 (344) 28 (337) 34 (332) 22 (327) 23 (345)
567
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
udenafil ulipristal acetate unoprostone isopropyl ester ustekinumab vadecoxib vaglancirclovir hydrochloride valaciclovir hydrochloride valrubicin valsartan vandetanib vardenafil varenicline vemurafenib venlafaxine vernakalant verteporfin
male sexual dysfunction contraception antiglaucoma
2005 2009 1994
41 (472) 45 (530) 30 (312)
antipsoriasis antiarthritic antiviral
2009 2002 2001
45 (532) 38 (369) 37 (273)
1995 1999 1996 2011 2003 2006 2011 1994 2010 2000
31 (352) 35 (350) 32 (320) 47 (555) 39 (286) 42 (547) 47 (556) 30 (312) 46 (491) 36 (312)
1990 1989 2011 2007 2009 1989 2012 1994 2002 2006 2013 1988 2004 1996 1992 1999 1993 1999 2005 1987 1997 1994 2000 2000 2000
26 (310) 25 (319) 47 (558) 43 (494) 46 (493) 25 (320) 48 (534) 30 (313) 38 (370) 42 (549) 49 (496) 24 (312) 40 (470) 32 (321) 28 (338) 35 (351) 29 (349) 35 (352) 41 (473) 23 (345) 33 (344) 30 (313) 36 (312) 36 (313) 36 (314)
antiviral anticancer antihypertensive anticancer male sexual dysfunction addiction, nicotine anticancer antidepressant antiarrhythmic ophthalmologic (macular degeneration) vesnarinone congestive heart failure vigabatrin anticonvulsant vilazodone antidepressant vildagliptin antidiabetic vinflunine anticancer vinorelbine anticancer vismodegib anticancer voglibose antidiabetic voriconazole antifungal vorinostat anticancer vortioxetine antidepressant xamoterol fumarate congestive heart failure ximelagatran anticoagulant zafirlukast antiasthma zalcitabine antiviral zaleplon sleep disorders zaltoprofen antiinflammatory zanamivir antiviral ziconotide analgesic zidovudine antiviral zileuton antiasthma zinostatin stimalamer anticancer ziprasidone hydrochloride antipsychotic zofenopril calcium antihypertensive zoledronate disodium osteoporosis
568
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
zolpidem hemitartrate zomitriptan zonisamide zopiclone zucapsaicin zuclopenthixol acetate
sleep disorders antimigraine anticonvulsant sleep disorders analgesic antipsychotic
1988 1997 1989 1986 2010 1987
24 33 25 22 46 23
(313) (345) (320) (327) (495) (345)
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
abacavir sulfate abarelix abatacept abiraterone acetate acarbose aceclofenac acemannan acetohydroxamic acid acetorphan acipimox acitretin aclidinium bromide
antiviral anticancer antiarthritic anticancer antidiabetic antiinflammatory wound healing agent urinary tract/bladder disorders antidiarrheal antihypercholesterolemic antipsoriasis chronic obstructive pulmonary disorder dyspepsia antiallergy antiinflammatory antiarthritic antibacterial antiviral anticancer
1999 2004 2006 2011 1990 1992 2001 1983 1993 1985 1989 2012
35 (333) 40 (446) 42 (509) 47 (505) 26 (297) 28 (325) 37 (259) 19 (313) 29 (332) 21 (323) 25 (309) 48 (481)
2013 1988 1994 2003 1984 2002 2013
49 (447) 24 (295) 30 (296) 39 (267) 20 (315) 38 (348) 49 (449)
sleep disorders antiinflammatory anticancer ophthalmologic, macular degeneration muscle relaxant Fabry’s disease antihypertensive ophthalmologic (allergic conjunctivitis) antiinflammatory
1986 1987 2013 2011
22 (315) 23 (325) 49 (451) 47 (507)
1983 2001 1988 2010
19 (313) 37 (259) 24 (296) 46 (444)
1985
21 (323)
antipsoriasis anticancer osteoporosis analgesic antihypertensive Gaucher’s disease Pompe disease antihypertensive anticancer
2003 2001 1993 1983 1988 1991 2006 2007 1999
39 (267) 37 (260) 29 (332) 19 (314) 24 (296) 27 (321) 42 (511) 43 (461) 35 (333)
acotiamide acrivastine actarit adalimumab adamantanium bromide adefovir dipivoxil ado-trastuzumab emtansine adrafinil AF-2259 afatinib aflibercept afloqualone agalsidase alfa alacepril alcaftadine alclometasone dipropionate alefacept alemtuzumab alendronate sodium alfentanil hydrochloride alfuzosin hydrochloride alglucerase alglucosidase alfa aliskiren alitretinoin
543
544
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
alminoprofen almotriptan alogliptin alosetron hydrochloride alpha-1 antitrypsin alpidem alpiropride alteplase alvimopan ambrisentan amfenac sodium amifostine aminoprofen amisulpride amlexanox amlodipine besylate amorolfine hydrochloride amosulalol ampiroxicam amprenavir amrinone amrubicin hydrochloride amsacrine amtolmetin guacil anagliptin anagrelide hydrochloride anakinra anastrozole angiotensin II anidulafungin aniracetam anti-digoxin polyclonal antibody APD apixaban apraclonidine hydrochloride aprepitant APSAC aranidipine arbekacin arformoterol argatroban arglabin aripiprazole
analgesic antimigraine antidiabetic irritable bowel syndrome emphysema anxiolytic antimigraine antithrombotic post-operative ileus pulmonary hypertension antiinflammatory cytoprotective antiinflammatory antipsychotic antiasthma antihypertensive antifungal antihypertensive antiinflammatory antiviral congestive heart failure anticancer anticancer antiinflammatory antidiabetic antithrombotic antiarthritic anticancer anticancer adjuvant antifungal cognition enhancer antidote, digoxin poisoning
1983 2000 2010 2000 1988 1991 1988 1987 2008 2007 1986 1995 1990 1986 1987 1990 1991 1988 1994 1999 1983 2002 1987 1993 2012 1997 2001 1995 1994 2006 1993 2002
19 (314) 36 (295) 46 (446) 36 (295) 24 (297) 27 (322) 24 (296) 23 (326) 44 (584) 43 (463) 22 (315) 31 (338) 26 (298) 22 (316) 23 (327) 26 (298) 27 (322) 24 (297) 30 (296) 35 (334) 19 (314) 38 (349) 23 (327) 29 (332) 48 (483) 33 (328) 37 (261) 31 (338) 30 (296) 42 (512) 29 (333) 38 (350)
osteoporosis antithrombotic antiglaucoma
1987 2011 1988
23 (326) 47 (509) 24 (297)
antiemetic antithrombotic antihypertensive antibacterial antiasthma antithrombotic anticancer antipsychotic
2003 1987 1996 1990 2007 1990 1999 2002
39 23 32 26 43 26 35 38
(268) (326) (306) (298) (465) (299) (335) (350)
545
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
armodafinil arotinolol hydrochloride arteether artemisinin asenapine aspoxicillin astemizole astromycin sulfate atazanavir atomoxetine
INDICATION
sleep disorders antihypertensive antimalarial antimalarial antipsychotic antibacterial antiallergy antibacterial antiviral attention deficit hyperactivity disorder atorvastatin calcium antihypercholesterolemic atosiban premature labor atovaquone antiparasitic auranofin antiarthritic avanafil male sexual dysfunction axitinib anticancer azacitidine anticancer azelaic acid acne azelastine hydrochloride antiallergy azelnidipine antihypertensive azilsartan antihypertensive azithromycin antibacterial azosemide diuretic aztreonam antibacterial balofloxacin antibacterial balsalazide disodium ulcerative colitis bambuterol antiasthma barnidipine hydrochloride antihypertensive beclobrate antihypercholesterolemic bedaquiline antibacterial befunolol hydrochloride antiglaucoma belatacept immunosuppressant belimumab lupus belotecan anticancer benazepril hydrochloride antihypertensive benexate hydrochloride antiulcer benidipine hydrochloride antihypertensive beraprost sodium antiplatelet besifloxacin antibacterial betamethasone butyrate antiinflammatory propionate betaxolol hydrochloride antihypertensive betotastine besilate antiallergy bevacizumab anticancer
YEAR ARMC VOL., INTRODUCED (PAGE)
2009 1986 2000 1987 2009 1987 1983 1985 2003 2003
45 (478) 22 (316) 36 (296) 23 (327) 45 (479) 23 (328) 19 (314) 21 (324) 39 (269) 39 (270)
1997 2000 1992 1983 2011 2012 2004 1989 1986 2003 2011 1988 1986 1984 2002 1997 1990 1992 1986 2012 1983 2011 2011 2004 1990 1987 1991 1992 2009 1994
33 (328) 36 (297) 28 (326) 19 (314) 47 (512) 48 (485) 40 (447) 25 (310) 22 (316) 39 (270) 47 (514) 24 (298) 22 (316) 20 (315) 38 (351) 33 (329) 26 (299) 28 (326) 22 (317) 48 (487) 19 (315) 47 (516) 47 (519) 40 (449) 26 (299) 23 (328) 27 (322) 28 (326) 45 (482) 30 (297)
1983 2000 2004
19 (315 36 (297) 40 (450)
546
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
bevantolol hydrochloride bexarotene biapenem bicalutamide bifemelane hydrochloride bilastine bimatoprost binfonazole binifibrate biolimus drug-eluting stent
antihypertensive anticancer antibacterial anticancer nootropic antiallergy antiglaucoma sleep disorders antihypercholesterolemic coronary artery disease, antirestenotic anticancer antihypertensive antithrombotic antipsychotic antiviral antihypertensive anticancer antihypertensive anticancer anticancer antiglaucoma antiglaucoma antibacterial antiinflammatory sleep disorders cerebral vasodilator immunomodulator congestive heart failure Parkinson’s disease antihypertensive antimalarial antihypertensive antidepressant hormone therapy anxiolytic antifungal antiinflammatory antifungal sleep disorders antiinflammatory anticancer antiprolactin anticancer wound healing agent
1987 2000 2002 1995 1987 2010 2001 1983 1986 2008
23 (328) 36 (298) 38 (351) 31 (338) 23 (329) 46 (449) 37 (261) 19 (315) 22 (317) 44 (586)
1990 1986 2000 2008 2011 1985 2003 2001 2012 2011 1996 1998 1993 1997 1983 1986 1987 1984 1997 1983 2000 1985 1989 1984 1985 1992 1992 1986 1984 1983 2010 1993 2012 1983
26 (300) 22 (317) 36 (298) 44 (587) 47 (521) 21 (324) 39 (271) 37 (262) 48 (489) 47 (523) 32 (306) 34 (318) 29 (333) 33 (329) 19 (315) 22 (317) 23 (329) 20 (316) 33 (330) 19 (315 36 (299) 21 (324) 25 (310) 20 (316) 21 (324) 28 (327) 28 (327) 22 (318) 20 (316) 19 (316) 46 (451) 29 (334) 48 (491) 19 (316)
bisantrene hydrochloride bisoprolol fumarate bivalirudin blonanserin boceprevir bopindolol bortezomib bosentan bosutinib brentuximab brimonidine brinzolamide brodimoprin bromfenac sodium brotizolam brovincamine fumarate bucillamine bucladesine sodium budipine budralazine bulaquine bunazosin hydrochloride bupropion hydrochloride buserelin acetate buspirone hydrochloride butenafine hydrochloride butibufen butoconazole butoctamide butyl flufenamate cabazitaxel cabergoline cabozantinib cadexomer iodine
547
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
cadralazine calcipotriol camostat mesylate canagliflozin canakinumab candesartan cilexetil capecitabine captopril carboplatin carfilzomib carperitide carumonam carvedilol caspofungin acetate catumaxomab cefbuperazone sodium cefcapene pivoxil cefdinir cefditoren pivoxil cefepime cefetamet pivoxil hydrochloride cefixime cefmenoxime hydrochloride cefminox sodium cefodizime sodium cefonicid sodium ceforanide cefoselis cefotetan disodium cefotiam hexetil hydrochloride cefozopran hydrochloride cefpimizole cefpiramide sodium cefpirome sulfate cefpodoxime proxetil cefprozil ceftaroline fosamil ceftazidime cefteram pivoxil ceftibuten ceftobiprole medocaril cefuroxime axetil
antihypertensive antipsoriasis anticancer antidiabetic antiinflammatory antihypertensive anticancer antihypertensive antibacterial anticancer congestive heart failure antibacterial antihypertensive antifungal anticancer antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial
1988 1991 1985 2013 2009 1997 1998 1982 1986 2012 1995 1988 1991 2001 2009 1985 1997 1991 1994 1993 1992
24 (298) 27 (323) 21 (325) 49 (453) 45 (484) 33 (330) 34 (319) 13 (086) 22 (318) 48 (492) 31 (339) 24 (298) 27 (323) 37 (263) 45 (486) 21 (325) 33 (330) 27 (323) 30 (297) 29 (334) 28 (327)
antibacterial antibacterial
1987 1983
23 (329) 19 (316)
antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial
1987 1990 1984 1984 1998 1984 1991
23 (330) 26 (300) 20 (316) 20 (317) 34 (319) 20 (317) 27 (324)
antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial
1995 1987 1985 1992 1989 1992 2010 1983 1987 1992 2008 1987
31 (339) 23 (330) 21 (325) 28 (328) 25 (310) 28 (328) 46 (453) 19 (316) 23 (330) 28 (329) 44 (589) 23 (331)
548
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
cefuzonam sodium celecoxib celiprolol hydrochloride centchroman centoxin cerivastatin certolizumab pegol cetilistat cetirizine hydrochloride cetrorelix cetuximab cevimeline hydrochloride chenodiol CHF-1301 choline alfoscerate choline fenofibrate cibenzoline ciclesonide cicletanine cidofovir cilazapril cilostazol cimetropium bromide cinacalcet cinildipine cinitapride cinolazepam ciprofibrate ciprofloxacin cisapride cisatracurium besilate citalopram cladribine clarithromycin clevidipine clevudine clobenoside cloconazole hydrochloride clodronate disodium clofarabine clopidogrel hydrogensulfate cloricromen clospipramine hydrochloride
antibacterial antiarthritic antihypertensive contraception immunomodulator antihypercholesterolemic irritable bowel syndrome antiobesity antiallergy infertility anticancer antixerostomia gallstones Parkinson’s disease cognition enhancer antihypercholesterolemic antiarrhythmic antiasthma antihypertensive antiviral antihypertensive antithrombotic antispasmodic hyperparathyroidism antihypertensive gastroprokinetic anxiolytic antihypercholesterolemic antibacterial gastroprokinetic muscle relaxant antidepressant anticancer antibacterial antihypertensive antiviral antiinflammatory antifungal calcium regulation anticancer antithrombotic
1987 1999 1983 1991 1991 1997 2008 2013 1987 1999 2003 2000 1983 1999 1990 2008 1985 2005 1988 1996 1990 1988 1985 2004 1995 1990 1993 1985 1986 1988 1995 1989 1993 1990 2008 2007 1988 1986 1986 2005 1998
23 (331) 35 (335) 19 (317 27 (324) 27 (325) 33 (331) 44 (592) 49 (454) 23 (331) 35 (336) 39 (272) 36 (299) 19 (317) 35 (336) 26 (300) 44 (594) 21 (325) 41 (443) 24 (299) 32 (306) 26 (301) 24 (299) 21 (326) 40 (451) 31 (339) 26 (301) 29 (334) 21 (326) 22 (318) 24 (299) 31 (340) 25 (311) 29 (335) 26 (302) 44 (596) 43 (466) 24 (300) 22 (318) 22 (319) 41 (444) 34 (320)
antithrombotic antipsychotic
1991 1991
27 (325) 27 (325)
549
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
cobicistat
INDICATION
antiviral pharmacokinetic enhancer) colesevelam hydrochloride antihypercholesterolemic colestimide antihypercholesterolemic colforsin daropate congestive heart failure hydrochloride conivaptan hyponatremia corifollitropin alfa infertility crizotinib anticancer crofelemer antidiarrheal crotelidae polyvalent antidote, snake venom poisoning immune fab cyclosporine immunosuppressant cytarabine ocfosfate anticancer dabigatran etexilate anticoagulant dabrafenib anticancer dalfampridine multiple sclerosis dalfopristin antibacterial dapagliflozin antidiabetic dapiprazole hydrochloride antiglaucoma dapoxetine premature ejaculation daptomycin antibacterial darifenacin urinary tract/bladder disorders darunavir antiviral dasatinib anticancer decitabine myelodysplastic syndromes defeiprone iron chelation therapy deferasirox iron chelation therapy defibrotide antithrombotic deflazacort antiinflammatory degarelix acetate anticancer delapril antihypertensive delavirdine mesylate antiviral denileukin diftitox anticancer denopamine congestive heart failure denosumab osteoporosis deprodone propionate antiinflammatory desflurane anesthetic desloratadine antiallergy desvenlafaxine antidepressant dexfenfluramine antiobesity dexibuprofen antiinflammatory dexlansoprazole antiulcer dexmedetomidine sleep disorders hydrochloride
YEAR ARMC VOL., INTRODUCED (PAGE)
2013
49 (456)
2000 1999 1999
36 (300) 35 (337) 35 (337)
2006 2010 2011 2012 2001
42 (514) 46 (455) 47 (525) 48 (494) 37 (263)
1983 1993 2008 2013 2010 1999 2012 1987 2009 2003 2005 2006 2006 2006 1995 2005 1986 1986 2009 1989 1997 1999 1988 2010 1992 1992 2001 2008 1997 1994 2009 2000
19 (317) 29 (335) 44 (598) 49 (458) 46 (458) 35 (338) 48 (495) 23 (332) 45 (488) 39 (272) 41 (445) 42 (515) 42 (517) 42 (519) 31 (340) 41 (446) 22 (319) 22 (319) 45 (490) 25 (311) 33 (331) 35 (338) 24 (300) 46 (459) 28 (329) 28 (329) 37 (264) 44 (600) 33 (332) 30 (298) 45 (492) 36 (301)
550
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
dexmethylphenidate hydrochloride dexrazoxane dezocine diacerein didanosine dilevalol dimethyl fumarate diquafosol tetrasodium dirithromycin disodium pamidronate divistyramine docarpamine docetaxel dofetilide dolasetron mesylate dolutegravir donepezil hydrochloride dopexamine doripenem dornase alfa dorzolamide hydrochloride dosmalfate doxacurium chloride doxazosin mesylate doxefazepam doxercalciferol doxifluridine doxofylline dronabinol dronedarone drospirenone drotrecogin alfa droxicam droxidopa duloxetine dutasteride duteplase ebastine eberconazole ebrotidine ecabet sodium ecallantide eculizumab
attention deficit hyperactivity disorder cardioprotective analgesic antiinflammatory antiviral antihypertensive multiple sclerosis ophthalmologic (dry eye) antibacterial osteoporosis antihypercholesterolemic congestive heart failure anticancer antiarrhythmic antiemetic antiviral Alzheimer’s disease congestive heart failure antibacterial cystic fibrosis antiglaucoma
2002
38 (352)
1992 1991 1985 1991 1989 2013 2010 1993 1989 1984 1994 1995 2000 1998 2013 1997 1989 2005 1994 1995
28 27 21 27 25 49 46 29 25 20 30 31 36 34 49 33 25 41 30 31
(330) (326) (326) (326) (311) (460) (462) (336) (312) (317) (298) (341) (301) (321) (461) (332) (312) (448) (298) (341)
antiulcer muscle relaxant antihypertensive anxiolytic hyperparathyroidism anticancer antiasthma antiemetic antiarrhythmic contraception antisepsis antiinflammatory Parkinson’s disease antidepressant benign prostatic hyperplasia anticoagulant antiallergy antifungal antiulcer antiulcer angioedema, hereditary hemoglobinuria
2000 1991 1988 1985 1999 1987 1985 1986 2009 2000 2001 1990 1989 2004 2002 1995 1990 2005 1997 1993 2009 2007
36 27 24 21 35 23 21 22 45 36 37 26 25 40 38 31 26 41 33 29 46 43
(302) (326) (300) (326) (339) (332) (327) (319) (495) (302) (265) (302) (312) (452) (353) (342) (302) (449) (333) (336) (464) (468)
551
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
edaravone edoxaban efalizumab efavirenz efinaconazole efonidipine egualen sodium eldecalcitol eletriptan eltrombopag elvitegravir emedastine difumarate emorfazone emtricitabine enalapril maleate enalaprilat encainide hydrochloride enfuvirtide enocitabine enoxacin enoxaparin enoximone enprostil entacapone entecavir enzalutamide epalrestat eperisone hydrochloride epidermal growth factor epinastine epirubicin hydrochloride eplerenone epoprostenol sodium eprosartan eptazocine hydrobromide eptilfibatide erdosteine eribulin mesylate erlotinib ertapenem sodium erythromycin acistrate erythropoietin escitalopram oxolate eslicarbazepine acetate esmolol hydrochloride
neuroprotective antithrombotic antipsoriasis antiviral antifungal antihypertensive antiulcer osteoporosis antimigraine antithrombocytopenic antiviral antiallergy analgesic antiviral antihypertensive antihypertensive antiarrhythmic antiviral anticancer antibacterial anticoagulant congestive heart failure antiulcer Parkinson’s disease antiviral anticancer antidiabetic muscle relaxant wound healing agent antiallergy anticancer antihypertensive antiplatelet antihypertensive analgesic antithrombotic expectorant anticancer anticancer antibacterial antibacterial hematopoietic antidepressant anticonvulsant antiarrhythmic
2001 2011 2003 1998 2013 1994 2000 2011 2001 2009 2013 1993 1984 2003 1984 1987 1987 2003 1983 1986 1987 1988 1985 1998 2005 2012 1992 1983 1987 1994 1984 2003 1983 1997 1987 1999 1995 2010 2004 2002 1988 1988 2002 2009 1987
37 (265) 47 (527) 39 (274) 34 (321) 49 (463) 30 (299) 36 (303) 47 (529) 37 (266) 45 (497) 49 (465) 29 (336) 20 (317) 39 (274) 20 (317) 23 (332) 23 (333) 39 (275) 19 (318) 22 (320) 23 (333) 24 (301) 21 (327) 34 (322) 41 (450) 48 (497) 28 (330) 19 (318) 23 (333) 30 (299) 20 (318) 39 (276) 19 (318) 33 (333) 23 (334) 35 (340) 31 (342) 46 (465) 40 (454) 38 (353) 24 (301) 24 (301) 38 (354) 45 (498) 23 (334)
552
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
esomeprazole magnesium eszopiclone ethyl icosapentate etizolam etodolac etoricoxibe etravirine everolimus exemestane exenatide exifone ezetimibe factor VIIa factor VIII fadrozole hydrochloride falecalcitriol famciclovir famotidine fasudil hydrochloride febuxostat felbamate felbinac felodipine fenbuprol fenoldopam mesylate fenticonazole nitrate fesoterodine fexofenadine fidaxomicin filgrastim finasteride fingolimod fisalamine fleroxacin flomoxef sodium flosequinan fluconazole fludarabine phosphate flumazenil
antiulcer sleep disorders antithrombotic anxiolytic antiinflammatory antiarthritic antiviral immunosuppressant anticancer antidiabetic cognition enhancer antihypercholesterolemic haemophilia hemostatic anticancer hyperparathyroidism antiviral antiulcer amyotrophic lateral sclerosis gout anticonvulsant antiinflammatory antihypertensive biliary tract dysfunction antihypertensive antifungal urinary tract/bladder disorders antiallergy antibacterial immunostimulant benign prostatic hyperplasia multiple sclerosis antiinflammatory antibacterial antibacterial congestive heart failure antifungal anticancer antidote, benzodiazepine overdose antiinflammatory antidepressant analgesic antibacterial
2000 2005 1990 1984 1985 2002 2008 2004 2000 2005 1988 2002 1996 1992 1995 2001 1994 1985 1995 2009 1993 1986 1988 1983 1998 1987 2008 1996 2011 1991 1992 2010 1984 1992 1988 1992 1988 1991 1987
36 (303) 41 (451) 26 (303) 20 (318) 21 (327) 38 (355) 44 (602) 40 (455) 36 (304) 41 (452) 24 (302) 38 (355) 32 (307) 28 (330) 31 (342) 37 (266) 30 (300) 21 (327) 31 (343) 45 (501) 29 (337) 22 (320) 24 (302) 19 (318) 34 (322) 23 (334) 44 (604) 32 (307) 47 (531) 27 (327) 28 (331) 46 (468) 20 (318) 28 (331) 24 (302) 28 (331) 24 (303) 27 (327) 23 (335)
1987 1986 1985 1997
23 22 21 33
flunoxaprofen fluoxetine hydrochloride flupirtine maleate flurithromycin ethylsuccinate
(335) (320) (328) (333)
553
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
flutamide flutazolam fluticasone furoate fluticasone propionate flutoprazepam flutrimazole flutropium bromide fluvastatin fluvoxamine maleate follitropin alfa follitropin beta fomepizole
INDICATION
anticancer anxiolytic antiallergy antiinflammatory anxiolytic antifungal antiasthma antihypercholesterolemic antidepressant infertility infertility antidote, ethylene glycol poisoning fomivirsen sodium antiviral fondaparinux sodium antithrombotic formestane anticancer formoterol fumarate chronic obstructive pulmonary disorder fosamprenavir antiviral fosaprepitant dimeglumine antiemetic foscarnet sodium antiviral fosfluconazole antifungal fosfosal analgesic fosinopril sodium antihypertensive fosphenytoin sodium anticonvulsant fotemustine anticancer fropenam antibacterial frovatriptan antimigraine fudosteine expectorant fulveristrant anticancer gabapentin anticonvulsant gabapentin Enacarbil restless leg syndrome gadoversetamide diagnostic gallium nitrate calcium regulation gallopamil hydrochloride antianginal galsulfase mucopolysaccharidosis VI ganciclovir antiviral ganirelix acetate infertility garenoxacin antibacterial gatilfloxacin antibacterial gefitinib anticancer gemcitabine hydrochloride anticancer gemeprost abortifacient gemifloxacin antibacterial gemtuzumab ozogamicin anticancer
YEAR ARMC VOL., INTRODUCED (PAGE)
1983 1984 2007 1990 1986 1995 1988 1994 1983 1996 1996 1998
19 (318) 20 (318) 43 (469) 26 (303) 22 (320) 31 (343) 24 (303) 30 (300) 19 (319) 32 (307) 32 (308) 34 (323)
1998 2002 1993 1986
34 (323) 38 (356) 29 (337) 22 (321)
2003 2008 1989 2004 1984 1991 1996 1989 1997 2002 2001 2002 1993 2011 2000 1991 1983 2005 1988 2000 2007 1999 2002 1995 1983 2004 2000
39 (277) 44 (606) 25 (313) 40 (457) 20 (319) 27 (328) 32 (308) 25 (313) 33 (334) 38 (357) 37 (267) 38 (357) 29 (338) 47 (533) 36 (304) 27 (328) 19 (3190) 41 (453) 24 (303) 36 (305) 43 (471) 35 (340) 38 (358) 31 (344) 19 (319) 40 (458) 36 (306)
554
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
gestodene gestrinone glatiramer acetate glimepiride glucagon, rDNA GMDP golimumab goserelin granisetron hydrochloride guanadrel sulfate gusperimus halobetasol propionate halofantrine halometasone histrelin hydrocortisone aceponate hydrocortisone butyrate ibandronic acid ibopamine hydrochloride ibritunomab tiuxetan ibrutinib ibudilast ibutilide fumarate icatibant idarubicin hydrochloride idebenone idursulfase
contraception contraception multiple sclerosis antidiabetic antidiabetic immunostimulant antiinflammatory hormone therapy antiemetic antihypertensive immunosuppressant antiinflammatory antimalarial antiinflammatory precocious puberty antiinflammatory antiinflammatory osteoporosis congestive heart failure anticancer anticancer antiasthma antiarrhythmic angioedema, hereditary anticancer nootropic mucopolysaccharidosis II (Hunter syndrome) antiarthritic antiplatelet anticancer urinary tract/bladder disorders antihypertensive Gaucher’s disease antibacterial antiviral osteoporosis chronic obstructive pulmonary disease antidepressant nootropic
1987 1986 1997 1995 1993 1996 2009 1987 1991 1983 1994 1991 1988 1983 1993 1988 1983 1996 1984 2002 2013 1989 1996 2008 1990 1986 2006
23 (335) 22 (321) 33 (334) 31 (344) 29 (338) 32 (308) 45 (503) 23 (336) 27 (329) 19 (319) 30 (300) 27 (329) 24 (304) 19 (320) 29 (338) 24 (304) 19 (320) 32 (309) 20 (319) 38 (359) 49 (466) 25 (313) 32 (309) 44 (608) 26 (303) 22 (321) 42 (520)
2011 1992 2001 2007 1993 1994 1985 1997 1997 2009
47 28 37 43 29 30 21 33 33 45
1983 1988
19 (320) 24 (304)
antiviral antiemetic antithrombotic
1996 2004 1984
32 (310) 40 (459) 20 (319)
iguratimod iloprost imatinib mesylate imidafenacin imidapril hydrochloride imiglucerase imipenem/cilastatin imiquimod incadronic acid indacaterol indalpine indeloxazine hydrochloride indinavir sulfate indisetron indobufen
(535) (332) (267) (472) (339) (301) (328) (335) (335) (505)
555
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
influenza virus (live) ingenol mebutate insulin lispro interferon alfacon-1 interferon gamma-1b interferon, b-1a interferon, b-1b interferon, gamma interferon, gamma-1 interleukin-2 ioflupane ipilimumab ipriflavone irbesartan irinotecan irsogladine isepamicin isofezolac isoxicam isradipine istradefylline itopride hydrochloride itraconazole ivabradine ivacaftor ivermectin ixabepilone ketanserin ketorolac tromethamine kinetin
antiviral anticancer antidiabetic antiviral immunostimulant multiple sclerosis multiple sclerosis antiinflammatory anticancer anticancer diagnostic anticancer osteoporosis antihypertensive anticancer antiulcer antibacterial antiinflammatory antiinflammatory antihypertensive Parkinson’s disease gastroprokinetic antifungal antianginal cystic fibrosis antiparasitic anticancer antihypertensive analgesic dermatologic, skin photodamage antihypertensive anticonvulsant antiulcer antiviral anticonvulsant antiarrhythmic antiviral antifungal growth disorders antiulcer anticancer mucopolysaccharidosis I antiglaucoma antiarthritic
2003 2012 1996 1997 1991 1996 1993 1989 1992 1989 2000 2011 1989 1997 1994 1989 1988 1984 1983 1989 2013 1995 1988 2006 2012 1987 2007 1985 1990 1999
39 (277) 48 (499) 32 (310) 33 (336) 27 (329) 32 (311) 29 (339) 25 (314) 28 (332) 25 (314) 36 (306) 47 (537) 25 (314) 33 (336) 30 (301) 25 (315) 24 (305) 20 (319) 19 (320) 25 (315) 49 (468) 31 (344) 24 (305) 42 (522) 48 (501) 23 (336) 43 (473) 21 (328) 26 (304) 35 (341)
1991 2008 2000 1995 1990 2002 2010 1994 1995 1992 2007 2003 1996 1998
27 (330) 44 (610) 36 (307) 31 (345) 26 (304) 38 (360) 46 (470) 30 (302) 31 (345) 28 (332) 43 (475) 39 (278) 32 (311) 34 (324)
lacidipine lacosamide lafutidine lamivudine lamotrigine landiolol laninamivir octanoate lanoconazole lanreotide acetate lansoprazole lapatinib laronidase latanoprost lefunomide
556
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
lenalidomide
myelodysplastic syndromes, multiple myeloma antibacterial
2006
42 (523)
1987
23 (336)
immunostimulant anticoagulant antihypertensive anticancer hormone therapy cognition enhancer
1986 1997 1997 1996 1984 1986
22 33 33 32 20 22
(322) (336) (337) (311) (319) (322)
antiasthma anticonvulsant antiglaucoma anesthetic
1999 2000 1985 2000
35 36 21 36
(341) (307) (328) (308)
antiallergy
1991
27 (330)
2001 1988 1993 2000 1984 1988 2012 2011 2000 2009 2000 2007
37 24 29 36 20 24 48 47 36 45 36 43
(268) (305) (340) (308) (320) (306) (502) (540) (309) (507) (309) (477)
1987 2013 1986 1992 1989 1999 2012 1987 2000 1983 1996 1992 1988 2012
23 49 22 28 25 35 48 23 36 19 32 28 24 48
(337) (470) (322) (333) (315) (342) (504) (337) (310) (321) (312) (333) (306) (506)
lenampicillin hydrochloride lentinan lepirudin lercanidipine letrazole leuprolide acetate levacecarnine hydrochloride levalbuterol hydrochloride levetiracetam levobunolol hydrochloride levobupivacaine hydrochloride levocabastine hydrochloride levocetirizine levodropropizine levofloxacin levosimendan lidamidine hydrochloride limaprost linaclotide linagliptin linezolid liraglutide liranaftate lisdexamfetamine
antiallergy antitussive antibacterial congestive heart failure antidiarrheal antithrombotic irritable bowel syndrome antidiabetic antibacterial antidiabetic antifungal attention deficit hyperactivity disorder lisinopril antihypertensive lixisenatide antidiabetic lobenzarit sodium antiinflammatory lodoxamide tromethamine antiallergy lomefloxacin antibacterial lomerizine hydrochloride antimigraine lomitapide antihypercholersteremic lonidamine anticancer lopinavir antiviral loprazolam mesylate sleep disorders loprinone hydrochloride congestive heart failure loracarbef antibacterial loratadine antiallergy lorcaserin hydrochloride antiobesity
557
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
lornoxicam losartan loteprednol etabonate lovastatin loxoprofen sodium lulbiprostone luliconazole lumiracoxib lurasidone hydrochloride Lyme disease vaccine mabuterol hydrochloride macitentan malotilate manidipine hydrochloride maraviroc masoprocol maxacalcitol mebefradil hydrochloride medifoxamine fumarate mefloquine hydrochloride meglutol melinamide meloxicam mepixanox meptazinol hydrochloride meropenem metaclazepam metapramine methylnaltrexone bromide metreleptin mexazolam micafungin mifamurtide mifepristone miglitol miglustat milnacipran milrinone miltefosine minodronic acid miokamycin mipomersen mirabegron mirtazapine misoprostol
antiinflammatory antihypertensive antiallergy antihypercholesterolemic antiinflammatory constipation antifungal antiinflammatory antipsychotic Lyme disease antiasthma pulmonary hypertension hepatoprotective antihypertensive antiviral anticancer hyperparathyroidism antihypertensive antidepressant antimalarial antihypercholesterolemic antihypercholesterolemic antiarthritic respiratory stimulant analgesic antibacterial anxiolytic antidepressant constipation lipodystrophy anxiolytic antifungal anticancer abortifacient antidiabetic Gaucher’s disease antidepressant congestive heart failure anticancer osteoporosis antibacterial antihypercholesterolemic urinary tract/bladder disorders antidepressant antiulcer
1997 1994 1998 1987 1986 2006 2005 2005 2010 1999 1986 2013 1985 1990 2007 1992 2000 1997 1986 1985 1983 1984 1996 1984 1983 1994 1987 1984 2008 2013 1984 2002 2009 1988 1998 2003 1997 1989 1993 2009 1985 2013 2011 1994 1985
33 (337) 30 (302) 34 (324) 23 (337) 22 (322) 42 (525) 41 (454) 41 (455) 46 (473) 35 (342) 22 (323) 49 (472) 21 (329) 26 (304) 43 (478) 28 (333) 36 (310) 33 (338) 22 (323) 21 (329) 19 (321) 20 (320) 32 (312) 20 (320) 19 (321) 30 (303) 23 (338) 20 (320) 44 (612) 49 (474) 20 (321) 38 (360) 46 (476) 24 (306) 34 (325) 39 (279) 33 (338) 25 (316) 29 (340) 45 (509) 21 (329) 49 (476) 47 (542) 30 (303) 21 (329)
558
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
mitiglinide mitoxantrone hydrochloride mivacurium chloride mivotilate mizolastine mizoribine moclobemide modafinil moexipril hydrochloride mofezolac mogamulizumab mometasone furoate montelukast sodium moricizine hydrochloride mosapride citrate moxifloxacin hydrochloride moxonidine mozavaptan mupirocin muromonab-CD3 muzolimine mycophenolate mofetil mycophenolate sodium nabumetone nadifloxacin nafamostat mesylate nafarelin acetate naftifine hydrochloride naftopidil nalfurafine hydrochloride nalmefene hydrochloride naltrexone hydrochloride naratriptan hydrochloride nartograstim natalizumab nateglinide nazasetron nebivolol nedaplatin nedocromil sodium nefazodone nelarabine nelfinavir mesylate
antidiabetic anticancer
2004 1984
40 (460) 20 (321)
muscle relaxant hepatoprotective antiallergy immunosuppressant antidepressant sleep disorders antihypertensive analgesic anticancer antiinflammatory antiasthma antiarrhythmic gastroprokinetic antibacterial
1992 1999 1998 1984 1990 1994 1995 1994 2012 1987 1998 1990 1998 1999
28 35 34 20 26 30 31 30 48 23 34 26 34 35
antihypertensive hyponatremia antibacterial immunosuppressant diuretic immunosuppressant immunosuppressant antiinflammatory antibacterial pancreatitis hormone therapy antifungal urinary tract/bladder disorders pruritus addiction, opioids addiction, opioids antimigraine leukopenia multiple sclerosis antidiabetic antiemetic antihypertensive anticancer antiallergy antidepressant anticancer antiviral
1991 2006 1985 1986 1983 1995 2003 1985 1993 1986 1990 1984 1999 2009 1995 1984 1997 1994 2004 1999 1994 1997 1995 1986 1994 2006 1997
27 (330) 42 (527) 21 (330) 22 (323) 19 (321) 31 (346) 39 (279) 21 (330) 29 (340) 22 (323) 26 (306) 20 (321) 35 (344) 45 (510) 31 (347) 20 (322) 33 (339) 30 (304) 40 (462) 35 (344) 30 (305) 33 (339) 31 (347) 22 (324) 30 (305) 42 (528) 33 (340)
(334) (343) (325) (321) (305) (303) (346) (304) (507) (338) (326) (305) (326) (343)
559
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
neltenexine nemonapride nepafenac neridronic acide nesiritide neticonazole hydrochloride nevirapine nicorandil nif ekalant hydrochloride nilotinib nilutamide nilvadipine nimesulide nimodipine nimotuzumab nipradilol nisoldipine nitisinone nitrefazole nitrendipine nizatidine nizofenzone nomegestrol acetate norelgestromin norfloxacin norgestimate obinutuzumab OCT-43 octreotide ofatumumab ofloxacin olanzapine olimesartan Medoxomil olodaterol
cystic fibrosis antipsychotic antiinflammatory calcium regulation congestive heart failure antifungal
1993 1991 2005 2002 2001 1993
29 (341) 27 (331) 41 (456) 38 (361) 37 (269) 29 (341)
1996 1984 1999 2007 1987 1989 1985 1985 2006 1988 1990 2002 1983 1985 1987 1988 1986 2002 1983 1986 2013 1999 1988 2009 1985 1996 2002 2013
32 (313) 20 (322) 35 (344) 43 (480) 23 (338) 25 (316) 21 (330) 21 (330) 42 (529) 24 (307) 26 (306) 38 (361) 19 (322) 21 (331) 23 (339) 24 (307) 22 (324) 38 (362) 19 (322) 22 (324) 49 (478) 35 (345) 24 (307) 45 (512) 21 (331) 32 (313) 38 (363) 49 (480)
1997 2012
33 (340) 48 (510)
2003 1988 1990
39 (280) 24 (308) 26 (306)
2001 1998
37 (269) 34 (327)
antiviral antianginal antiarrhythmic anticancer anticancer antihypertensive antiinflammatory cerebral vasodilator anticancer antihypertensive antihypertensive antityrosinaemia addiction, alcohol antihypertensive antiulcer nootropic contraception contraception antibacterial contraception anticancer anticancer growth disorders anticancer antibacterial antipsychotic antihypertensive chronic obstructive pulmonary disorder olopatadine hydrochloride antiallergy omacetaxine anticancer mepesuccinate omalizumab allergic antiasthma omeprazole antiulcer ondansetron antiemetic hydrochloride OP-1 osteoinductor orlistat antiobesity
560
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
ornoprostil osalazine sodium oseltamivir phosphate ospemifene oxaliplatin oxaprozin oxcarbazepine oxiconazole nitrate oxiracetam oxitropium bromide ozagrel sodium paclitaxal palifermin paliperidone palonosetron panipenem/ betamipron carbapenem panitumumab pantoprazole sodium parecoxib sodium paricalcitol parnaparin sodium paroxetine pasireotide pazopanib pazufloxacin pefloxacin mesylate pegademase bovine pegaptanib
antiulcer antiinflammatory antiviral dyspareunia anticancer antiinflammatory anticonvulsant antifungal cognition enhancer antiasthma antithrombotic anticancer mucositis antipsychotic antiemetic antibacterial
1987 1986 1999 2013 1996 1983 1990 1983 1987 1983 1988 1993 2005 2007 2003 1994
23 (339) 22 (324) 35 (346) 49 (482) 32 (313) 19 (322) 26 (307) 19 (322) 23 (339) 19 (323) 24 (308) 29 (342) 41 (461) 43 (482) 39 (281) 30 (305)
2006 1995 2002 1998 1993 1991 2012 2009 2002 1985 1990 2005
42 30 38 34 29 27 48 45 38 21 26 41
1994 2012 2003 2004 1991 1996 1992 2010 2012 1988 1988 2001 2012 1987 1993
30 (306) 48 (514) 39 (281) 40 (463) 27 (331) 32 (314) 28 (334) 46 (477) 48 (516) 24 (308) 24 (309) 37 (270) 48 (517) 23 (340) 29 (343)
anticancer antiulcer analgesic hyperparathyroidism anticoagulant antidepressant Cushing’s Disease anticancer antibacterial antibacterial immunostimulant ophthalmologic (macular degeneration) pegaspargase anticancer peginesatide acetate hematopoietic pegvisomant growth disorders pemetrexed anticancer pemirolast potassium antiasthma penciclovir antiviral pentostatin anticancer peramivir antiviral perampanel anticonvulsant pergolide mesylate Parkinson’s disease perindopril antihypertensive perospirone hydrochloride antipsychotic pertuzumab anticancer picotamide antithrombotic pidotimod immunostimulant
(531) (306) (364) (327) (342) (331) (512) (514) (364) (331) (307) (458)
561
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
piketoprofen pilsicainide hydrochloride pimaprofen pimecrolimus pimobendan pinacidil pioglitazone hydrochloride pirarubicin pirfenidone pirmenol piroxicam cinnamate pitavastatin pivagabine pixantrone dimaleate plaunotol plerixafor hydrochloride polaprezinc pomalidomide ponatinib porfimer sodium posaconazole pralatrexate pramipexole hydrochloride pramiracetam sulfate pramlintide pranlukast prasugrel pravastatin prednicarbate pregabalin prezatide copper acetate progabide promegestrone propacetamol hydrochloride propagermanium propentofylline propionate propiverine hydrochloride propofol prulifloxacin pumactant quazepam quetiapine fumarate quinagolide
antiinflammatory antiarrhythmic antiinflammatory immunosuppressant congestive heart failure antihypertensive antidiabetic anticancer pulmonary fibrosis, idiopathic antiarrhythmic antiinflammatory antihypercholesterolemic antidepressant anticancer antiulcer stem cell mobilizer antiulcer anticancer anticancer anticancer antifungal anticancer Parkinson’s disease
1984 1991 1984 2002 1994 1987 1999 1988 2008 1994 1988 2003 1997 2012 1987 2009 1994 2013 2012 1993 2006 2009 1997
20 (322) 27 (332) 20 (322) 38 (365) 30 (307) 23 (340) 35 (346) 24 (309) 44 (614) 30 (307) 24 (309) 39 (282) 33 (341) 48 (519) 23 (340) 45 (515) 30 (307) 49 (484) 48 (521) 29 (343) 42 (532) 45 (517) 33 (341)
cognition enhancer antidiabetic antiasthma antiplatelet antihypercholesterolemic antiinflammatory anticonvulsant wound healing agent anticonvulsant contraception analgesic
1993 2005 1995 2009 1989 1986 2004 1996 1985 1983 1986
29 (343) 41 (460) 31 (347) 45 (519) 25 (316) 22 (325) 40 (464) 32 (314) 21 (331) 19 (323) 22 (325)
antiviral cerebral vasodilator urinary tract/bladder disorders anesthetic antibacterial respiratory distress syndrome sleep disorders antipsychotic hyperprolactinemia
1994 1988 1992 1986 2002 1994 1985 1997 1994
30 (308) 24 (310) 28 (335) 22 (325) 38 (366) 30 (308) 21 (332) 33 (341) 30 (309)
562
GENERIC NAME
quinapril quinf amideamebicide quinupristin rabeprazole sodium radotinib raloxifene hydrochloride raltegravir raltitrexed ramatroban ramelteon ramipril ramosetron ranibizumab
Cumulative NCE Introduction Index, 1983–2013
INDICATION
antihypertensive antiparasitic antibacterial antiulcer anticancer osteoporosis antiviral anticancer antiallergy sleep disorders antihypertensive antiemetic ophthalmologic (macular degeneration) ranimustine anticancer ranitidine bismuth citrate antiulcer ranolazine antianginal rapacuronium bromide muscle relaxant rasagiline Parkinson’s disease rebamipide antiulcer reboxetine antidepressant regorafenib anticancer remifentanil hydrochloride analgesic remoxipride antipsychotic hydrochloride repaglinide antidiabetic repirinast antiallergy retapamulin antibacterial reteplase antithrombotic retigabine anticonvulsant reviparin sodium anticoagulant rifabutin antibacterial rifapentine antibacterial rifaximin antibacterial rifaximin antibacterial rilmazafone sleep disorders rilmenidine antihypertensive rilonacept genetic autoinflammatory syndromes rilpivirine antiviral riluzole amyotrophic lateral sclerosis rimantadine hydrochloride antiviral rimexolone antiinflammatory rimonabant antiobesity riociguat pulmonary hypertension
YEAR ARMC VOL., INTRODUCED (PAGE)
1989 1984 1999 1998 2012 1998 2007 1996 2000 2005 1989 1996 2006
25 (317) 20 (322) 35 (338) 34 (328) 48 (523) 34 (328) 43 (484) 32 (315) 36 (311) 41 (462) 25 (317) 32 (315) 42 (534)
1987 1995 2006 1999 2005 1990 1997 2012 1996 1990
23 31 42 35 41 26 33 48 32 26
(341) (348) (535) (347) (464) (308) (342) (524) (316) (308)
1998 1987 2007 1996 2011 1993 1992 1988 1987 1985 1989 1988 2008
34 23 43 32 47 29 28 24 23 21 25 24 44
(329) (341) (486) (316) (544) (344) (335) (310) (341) (332) (317) (310) (615)
2011 1996 1987 1995 2006 2013
47 32 23 31 42 49
(546) (316) (342) (348) (537) (486)
563
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
risedronate sodium risperidone ritonavir rivaroxaban rivastigmin rizatriptan benzoate rocuronium bromide rofecoxib roflumilast
osteoporosis antipsychotic antiviral anticoagulant Alzheimer’s disease antimigraine muscle relaxant antiarthritic chronic obstructive pulmonary disorder antibacterial anticancer antithrombocytopenic immunostimulant antihypercholesterolemic Parkinson’s disease anesthetic antiulcer antidiabetic antihypercholesterolemic Parkinson’s disease antiulcer
1998 1993 1996 2008 1997 1998 1994 1999 2010
34 (330) 29 (344) 32 (317) 44 (617) 33 (342) 34 (330) 30 (309) 35 (347) 46 (480)
1986 2009 2008 1991 1986 1996 1996 1985 1999 2003 2006 1986
22 (325) 46 (482) 44 (619) 27 (332) 22 (326) 32 (317) 32 (318) 21 (332) 35 (348) 39 (283) 42 (538) 22 (326)
antiulcer anticonvulsant antibacterial antiallergy anticancer antibacterial antiasthma
1987 2007 1992 2003 2011 1989 1990
23 (342) 43 (488) 28 (335) 39 (284) 47 (548) 25 (318) 26 (308)
phenylketouria antiviral immunostimulant antidiabetic antithrombotic antidiabetic immunostimulant antiasthma antifungal antipsychotic antiallergy antidepressant antidepressant anesthetic
1992 1995 1991 2013 1993 2009 1985 1995 1992 1996 1987 1989 1990 1990
28 (336) 31 (349) 27 (332) 49 (488) 29 (344) 45 (521) 22 (326) 31 (349) 28 (336) 32 (318) 23 (342) 25 (318) 26 (309) 26 (309)
rokitamycin romidepsin romiplostim romurtide ronafibrate ropinirole hydrochloride ropivacaine rosaprostol rosiglitazone maleate rosuvastatin rotigotine roxatidine acetate hydrochloride roxithromycin rufinamide rufloxacin hydrochloride rupatadine fumarate ruxolitinib RV-11 salmeterol hydroxynaphthoate sapropterin hydrochloride saquinavir mesvlate sargramostim saroglitazar sarpogrelate hydrochloride saxagliptin schizophyllan seratrodast sertaconazole nitrate sertindole setastine hydrochloride setiptiline setraline hydrochloride sevoflurane
564
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
sibutramine sildenafil citrate silodosin simeprevir simvastatin sipuleucel-t sitafloxacin hydrate sitagliptin sitaxsentan sivelestat SKI-2053R sobuzoxane sodium cellulose phosphate sofalcone sofosbuvir solifenacin somatomedin-1 somatotropin somatropin sorafenib sorivudine sparfloxacin spirapril hydrochloride spizofurone stavudine strontium ranelate succimer sufentanil sugammadex
antiobesity male sexual dysfunction urinary tract/bladder disorders antiviral antihypercholesterolemic anticancer antibacterial antidiabetic pulmonary hypertension antiinflammatory anticancer anticancer urinary tract/bladder disorders antiulcer antiviral urinary tract/bladder disorders growth disorders growth disorders growth disorders anticancer antiviral antibacterial antihypertensive antiulcer antiviral osteoporosis antidote, lead poisoning analgesic neuromuscular blockade, reversal antibacterial antifungal antibacterial antimigraine anticancer antiallergy analgesic respiratory surfactant antipsoriasis Alzheimer’s disease immunosuppressant male sexual dysfunction neurodegeneration antiglaucoma anticancer
1998 1998 2006 2013 1988 2010 2008 2006 2006 2002 1999 1994 1983 1984 2013 2004 1994 1994 1987 2005 1993 1993 1995 1987 1994 2004 1991 1983 2008
34 (331) 34 (331) 42 (540) 49 (489) 24 (311) 46 (484) 44 (621) 42 (541) 42 (543) 38 (366) 35 (348) 30 (310) 19 (323) 20 (323) 49 (492) 40 (466) 30 (310) 30 (310) 23 (343) 41 (466) 29 (345) 29 (345) 31 (349) 23 (343) 30 (311) 40 (466) 27 (333) 19 (323) 44 (623)
1986 1985 1987 1991 2006 1995 1983 1987 1993 1993 1993 2003 2011 2008 2004
22 21 23 27 42 31 19 23 29 29 29 39 47 44 40
sulbactam sodium sulconizole nitrate sultamycillin tosylate sumatriptan succinate sunitinib suplatast tosilate suprofen surfactant TA tacalcitol tacrine hydrochloride tacrolimus tadalafil tafamidis tafluprost talaporfin sodium
(326) (332) (343) (333) (544) (350) (324) (344) (346) (346) (347) (284) (550) (625) (469)
565
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
talipexole taltirelin tamibarotene tamsulosin hydrochloride tandospirone tapentadol hydrochloride tasonermin tazanolast tazarotene tazobactam sodium teduglutide tegaserod maleate teicoplanin telaprevir telavancin telbivudine telithromycin telmesteine telmisartan temafloxacin hydrochloride temocapril temocillin disodium temoporphin temozolomide temsirolimus teneligliptin tenofovir disoproxil fumarate tenoxicam teprenone terazosin hydrochloride terbinafine hydrochloride terconazole teriflunomide tertatolol hydrochloride tesamorelin acetate thrombin alfa thrombomodulin (recombinant) thymopentin tiagabine tiamenidine hydrochloride tianeptine sodium tibolone
Parkinson’s disease neurodegeneration anticancer benign prostatic hyperplasia anxiolytic analgesic anticancer antiallergy antipsoriasis antibacterial short bowel syndrome irritable bowel syndrome antibacterial antiviral antibacterial antiviral antibacterial expectorant antihypertensive antibacterial
1996 2000 2005 1993 1996 2009 1999 1990 1997 1992 2012 2001 1988 2011 2009 2006 2001 1992 1999 1991
32 (318) 36 (311) 41 (467) 29 (347) 32 (319) 45 (523) 35 (349) 26 (309) 33 (343) 28 (336) 48 (526) 37 (270) 24 (311) 47 (552) 45 (525) 42 (546) 37 (271) 28 (337) 35 (349) 27 (334)
antihypertensive antibacterial anticancer anticancer anticancer antidiabetic antiviral
1994 1984 2002 1999 2007 2012 2001
30 (311) 20 (323) 38 (367) 35 (349) 43 (490) 48 (528) 37 (271)
antiinflammatory antiulcer antihypertensive antifungal antifungal multiple sclerosis antihypertensive lipodystrophy hemostatic anticoagulant
1987 1984 1984 1991 1983 2012 1987 2010 2008 2008
23 (344) 20 (323) 20 (323) 27 (334) 19 (324) 48 (530) 23 (344) 46 (486) 44 (627) 44 (628)
immunomodulator anticonvulsant antihypertensive antidepressant hormone therapy
1985 1996 1988 1983 1988
21 (333) 32 (319) 24 (311) 19 (324) 24 (312)
566
GENERIC NAME
ticagrelor tigecycline tilisolol hydrochloride tiludronate disodium timiperone tinazoline tioconazole tiopronin tiotropium bromide
Cumulative NCE Introduction Index, 1983–2013
INDICATION
antithrombotic antibacterial antihypertensive Paget’s disease antipsychotic nasal decongestant antifungal urolithiasis chronic obstructive pulmonary disorder tipranavir antiviral tiquizium bromide antispasmodic tiracizine hydrochloride antiarrhythmic tirilazad mesylate subarachnoid hemorrhage tirofiban hydrochloride antithrombotic tiropramide hydrochloride muscle relaxant tizanidine muscle relaxant tofacitinib antiarthritic tolcapone Parkinson’s disease toloxatone antidepressant tolrestat antidiabetic tolvaptan hyponatremia topiramate anticonvulsant topotecan hydrochloride anticancer torasemide diuretic toremifene anticancer tositumomab anticancer tosufloxacin tosylate antibacterial trabectedin anticancer trametinib anticancer trandolapril antihypertensive travoprost antiglaucoma treprostinil sodium antihypertensive tretinoin tocoferil antiulcer trientine hydrochloride antidote, copper poisoning trimazosin hydrochloride antihypertensive trimegestone contraception trimetrexate glucuronate antifungal troglitazone antidiabetic tropisetron antiemetic trovafloxacin mesylate antibacterial troxipide antiulcer ubenimex immunostimulant
YEAR ARMC VOL., INTRODUCED (PAGE)
2010 2005 1992 1995 1984 1988 1983 1989 2002
46 41 28 31 20 24 19 25 38
(488) (468) (337) (350) (323) (312) (324) (318) (368)
2005 1984 1990 1995 1998 1983 1984 2012 1997 1984 1989 2009 1995 1996 1993 1989 2003 1990 2007 2013 1993 2001 2002 1993 1986 1985 2001 1994 1997 1992 1998 1986 1987
41 (470) 20 (324) 26 (310) 31 (351) 34 (332) 19 (324) 20 (324) 48 (532) 33 (343) 20 (324) 25 (319) 45 (528) 31 (351) 32 (320) 29 (348) 25 (319) 39 (285) 26 (310) 43 (492) 49 (494) 29 (348) 37 (272) 38 (368) 29 (348) 22 (327) 21 (333) 37 (273) 30 (312) 33 (344) 28 (337) 34 (332) 22 (327) 23 (345)
567
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
udenafil ulipristal acetate unoprostone isopropyl ester ustekinumab vadecoxib vaglancirclovir hydrochloride valaciclovir hydrochloride valrubicin valsartan vandetanib vardenafil varenicline vemurafenib venlafaxine vernakalant verteporfin
male sexual dysfunction contraception antiglaucoma
2005 2009 1994
41 (472) 45 (530) 30 (312)
antipsoriasis antiarthritic antiviral
2009 2002 2001
45 (532) 38 (369) 37 (273)
1995 1999 1996 2011 2003 2006 2011 1994 2010 2000
31 (352) 35 (350) 32 (320) 47 (555) 39 (286) 42 (547) 47 (556) 30 (312) 46 (491) 36 (312)
1990 1989 2011 2007 2009 1989 2012 1994 2002 2006 2013 1988 2004 1996 1992 1999 1993 1999 2005 1987 1997 1994 2000 2000 2000
26 (310) 25 (319) 47 (558) 43 (494) 46 (493) 25 (320) 48 (534) 30 (313) 38 (370) 42 (549) 49 (496) 24 (312) 40 (470) 32 (321) 28 (338) 35 (351) 29 (349) 35 (352) 41 (473) 23 (345) 33 (344) 30 (313) 36 (312) 36 (313) 36 (314)
antiviral anticancer antihypertensive anticancer male sexual dysfunction addiction, nicotine anticancer antidepressant antiarrhythmic ophthalmologic (macular degeneration) vesnarinone congestive heart failure vigabatrin anticonvulsant vilazodone antidepressant vildagliptin antidiabetic vinflunine anticancer vinorelbine anticancer vismodegib anticancer voglibose antidiabetic voriconazole antifungal vorinostat anticancer vortioxetine antidepressant xamoterol fumarate congestive heart failure ximelagatran anticoagulant zafirlukast antiasthma zalcitabine antiviral zaleplon sleep disorders zaltoprofen antiinflammatory zanamivir antiviral ziconotide analgesic zidovudine antiviral zileuton antiasthma zinostatin stimalamer anticancer ziprasidone hydrochloride antipsychotic zofenopril calcium antihypertensive zoledronate disodium osteoporosis
568
Cumulative NCE Introduction Index, 1983–2013
GENERIC NAME
INDICATION
YEAR ARMC VOL., INTRODUCED (PAGE)
zolpidem hemitartrate zomitriptan zonisamide zopiclone zucapsaicin zuclopenthixol acetate
sleep disorders antimigraine anticonvulsant sleep disorders analgesic antipsychotic
1988 1997 1989 1986 2010 1987
24 33 25 22 46 23
(313) (345) (320) (327) (495) (345)