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Cumulative NCE Introduction Index, 1983–2012
CUMULATIVE NCE INTRODUCTION INDEX, 1983–2012 GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
abacavir sulfate abarelix abatacept abiraterone acetate acarbose aceclofenac acemannan acetohydroxamic acid
antiviral anticancer antiarthritic anticancer antidiabetic antiinflammatory wound healing agent urinary tract/bladder disorders antidiarrheal antihypercholesterolemic antipsoriasis chronic obstructive pulmonary disorder antiallergy antiinflammatory antiarthritic antibacterial antiviral sleep disorders antiinflammatory ophthalmologic, macular degeneration muscle relaxant Fabry’s disease antihypertensive ophthalmologic (allergic conjunctivitis) antiinflammatory
1999 2004 2006 2011 1990 1992 2001 1983
35 40 42 47 26 28 37 19
(333) (446) (509) (505) (297) (325) (259) (313)
1993 1985 1989 2012
29 21 25 48
(332) (323) (309) (481)
1988 1994 2003 1984 2002 1986 1987 2011
24 30 39 20 38 22 23 47
(295) (296) (267) (315) (348) (315) (325) (507)
1983 2001 1988 2010
19 37 24 46
(313) (259) (296) (444)
1985
21 (323)
antipsoriasis anticancer osteoporosis analgesic antihypertensive Gaucher’s disease Pompe disease antihypertensive anticancer analgesic antimigraine
2003 2001 1993 1983 1988 1991 2006 2007 1999 1983 2000
39 37 29 19 24 27 42 43 35 19 36
acetorphan acipimox acitretin aclidinium bromide acrivastine actarit adalimumab adamantanium bromide adefovir dipivoxil adrafinil AF-2259 aflibercept afloqualone agalsidase alfa alacepril alcaftadine alclometasone dipropionate alefacept alemtuzumab alendronate sodium alfentanil hydrochloride alfuzosin hydrochloride alglucerase alglucosidase alfa aliskiren alitretinoin alminoprofen almotriptan
(267) (260) (332) (314) (296) (321) (511) (461) (333) (314) (295)
579
580
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
alogliptin alosetron hydrochloride alpha-1 antitrypsin alpidem alpiropride alteplase alvimopan ambrisentan amfenac sodium amifostine aminoprofen amisulpride amlexanox amlodipine besylate amorolfine hydrochloride amosulalol ampiroxicam amprenavir amrinone amrubicin hydrochloride amsacrine amtolmetin guacil anagliptin anagrelide hydrochloride anakinra anastrozole angiotensin II anidulafungin aniracetam anti-digoxin polyclonal antibody APD apixaban apraclonidine hydrochloride aprepitant APSAC aranidipine arbekacin arformoterol argatroban arglabin
antidiabetic irritable bowel syndrome emphysema anxiolytic antimigraine antithrombotic post-operative ileus pulmonary hypertension antiinflammatory cytoprotective antiinflammatory antipsychotic antiasthma antihypertensive antifungal
2010 2000 1988 1991 1988 1987 2008 2007 1986 1995 1990 1986 1987 1990 1991
46 (446) 36 (295) 24 (297) 27 (322) 24 (296) 23 (326) 44 (584) 43 (463) 22 (315) 31 (338) 26 (298) 22 (316) 23 (327) 26 (298) 27 (322)
antihypertensive antiinflammatory antiviral congestive heart failure anticancer
1988 1994 1999 1983 2002
24 (297) 30 (296) 35 (334) 19 (314) 38 (349)
anticancer antiinflammatory antidiabetic antithrombotic
1987 1993 2012 1997
23 (327) 29 (332) 48 (483) 33 (328)
antiarthritic anticancer anticancer adjuvant antifungal cognition enhancer antidote, digoxin poisoning
2001 1995 1994 2006 1993 2002
37 (261) 31 (338) 30 (296) 42 (512) 29 (333) 38 (350)
osteoporosis antithrombotic antiglaucoma
1987 2011 1988
23 (326) 47 (509) 24 (297)
antiemetic antithrombotic antihypertensive antibacterial antiasthma antithrombotic anticancer
2003 1987 1996 1990 2007 1990 1999
39 (268) 23 (326) 32 (306) 26 (298) 43 (465) 26 (299) 35 (335)
581
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
aripiprazole armodafinil arotinolol hydrochloride arteether artemisinin asenapine aspoxicillin astemizole astromycin sulfate atazanavir atomoxetine
antipsychotic sleep disorders antihypertensive
2002 2009 1986
38 (350) 45 (478) 22 (316)
antimalarial antimalarial antipsychotic antibacterial antiallergy antibacterial antiviral attention deficit hyperactivity disorder antihypercholesterolemic premature labor antiparasitic antiarthritic male sexual dysfunction anticancer anticancer acne antiallergy
2000 1987 2009 1987 1983 1985 2003 2003
36 23 45 23 19 21 39 39
(296) (327) (479) (328) (314) (324) (269) (270)
1997 2000 1992 1983 2011 2012 2004 1989 1986
33 36 28 19 47 48 40 25 22
(328) (297) (326) (314) (512) (485) (447) (310) (316)
antihypertensive antihypertensive antibacterial diuretic antibacterial antibacterial ulcerative colitis antiasthma antihypertensive
2003 2011 1988 1986 1984 2002 1997 1990 1992
39 47 24 22 20 38 33 26 28
(270) (514) (298) (316) (315) (351) (329) (299) (326)
antihypercholesterolemic antibacterial antiglaucoma
1986 2012 1983
22 (317) 48 (487) 19 (315)
immunosuppressant lupus anticancer antihypertensive
2011 2011 2004 1990
47 47 40 26
antiulcer antihypertensive
1987 1991
23 (328) 27 (322)
atorvastatin calcium atosiban atovaquone auranofin avanafil axitinib azacitidine azelaic acid azelastine hydrochloride azelnidipine azilsartan azithromycin azosemide aztreonam balofloxacin balsalazide disodium bambuterol barnidipine hydrochloride beclobrate bedaquiline befunolol hydrochloride belatacept belimumab belotecan benazepril hydrochloride benexate hydrochloride benidipine hydrochloride
(516) (519) (449) (299)
582
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
beraprost sodium besifloxacin betamethasone butyrate propionate betaxolol hydrochloride betotastine besilate bevacizumab bevantolol hydrochloride bexarotene biapenem bicalutamide bifemelane hydrochloride bilastine bimatoprost binfonazole binifibrate biolimus drug-eluting stent bisantrene hydrochloride bisoprolol fumarate bivalirudin blonanserin boceprevir bopindolol bortezomib bosentan bosutinib brentuximab brimonidine brinzolamide brodimoprin bromfenac sodium brotizolam brovincamine fumarate bucillamine bucladesine sodium budipine budralazine bulaquine bunazosin hydrochloride
antiplatelet antibacterial antiinflammatory
1992 2009 1994
28 (326) 45 (482) 30 (297)
antihypertensive
1983
19 (315)
antiallergy anticancer antihypertensive
2000 2004 1987
36 (297) 40 (450) 23 (328)
anticancer antibacterial anticancer nootropic
2000 2002 1995 1987
36 (298) 38 (351) 31 (338) 23 (329)
antiallergy antiglaucoma sleep disorders antihypercholesterolemic coronary artery disease, antirestenotic anticancer
2010 2001 1983 1986 2008
46 (449) 37 (261) 19 (315) 22 (317) 44 (586)
1990
26 (300)
antihypertensive antithrombotic antipsychotic antiviral antihypertensive anticancer antihypertensive anticancer anticancer antiglaucoma antiglaucoma antibacterial antiinflammatory sleep disorders cerebral vasodilator immunomodulator congestive heart failure Parkinson’s disease antihypertensive antimalarial antihypertensive
1986 2000 2008 2011 1985 2003 2001 2012 2011 1996 1998 1993 1997 1983 1986 1987 1984 1997 1983 2000 1985
22 (317) 36 (298) 44 (587) 47 (521) 21 (324) 39 (271) 37 (262) 48 (489) 47 (523) 32 (306) 34 (318) 29 (333) 33 (329) 19 (315) 22 (317) 23 (329) 20 (316) 33 (330) 19 (315) 36 (299) 21 (324)
583
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
bupropion hydrochloride buserelin acetate buspirone hydrochloride butenafine hydrochloride butibufen butoconazole butoctamide butyl flufenamate cabazitaxel cabergoline cabozantinib cadexomer iodine cadralazine calcipotriol camostat mesylate canakinumab candesartan cilexetil capecitabine captopril carboplatin carfilzomib carperitide carumonam carvedilol caspofungin acetate catumaxomab cefbuperazone sodium cefcapene pivoxil cefdinir cefditoren pivoxil cefepime cefetamet pivoxil hydrochloride cefixime cefmenoxime hydrochloride cefminox sodium cefodizime sodium cefonicid sodium ceforanide cefoselis cefotetan disodium
antidepressant
1989
25 (310)
hormone therapy anxiolytic
1984 1985
20 (316) 21 (324)
antifungal
1992
28 (327)
antiinflammatory antifungal sleep disorders antiinflammatory anticancer antiprolactin anticancer wound healing agent antihypertensive antipsoriasis anticancer antiinflammatory antihypertensive anticancer antihypertensive antibacterial anticancer congestive heart failure antibacterial antihypertensive antifungal anticancer antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial
1992 1986 1984 1983 2010 1993 2012 1983 1988 1991 1985 2009 1997 1998 1982 1986 2012 1995 1988 1991 2001 2009 1985 1997 1991 1994 1993 1992
28 22 20 19 46 29 48 19 24 27 21 45 33 34 13 22 48 31 24 27 37 45 21 33 27 30 29 28
antibacterial antibacterial
1987 1983
23 (329) 19 (316)
antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial
1987 1990 1984 1984 1998 1984
23 26 20 20 34 20
(327) (318) (316) (316) (451) (334) (491) (316) (298) (323) (325) (484) (330) (319) (086) (318) (492) (339) (298) (323) (263) (486) (325) (330) (323) (297) (334) (327)
(330) (300) (316) (317) (319) (317)
584
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
cefotiam hexetil hydrochloride cefozopran hydrochloride cefpimizole cefpiramide sodium cefpirome sulfate cefpodoxime proxetil cefprozil ceftaroline fosamil ceftazidime cefteram pivoxil ceftibuten ceftobiprole medocaril cefuroxime axetil cefuzonam sodium celecoxib celiprolol hydrochloride centchroman centoxin cerivastatin certolizumab pegol cetirizine hydrochloride cetrorelix cetuximab cevimeline hydrochloride chenodiol CHF-1301 choline alfoscerate choline fenofibrate cibenzoline ciclesonide cicletanine cidofovir cilazapril cilostazol cimetropium bromide cinacalcet cinildipine cinitapride cinolazepam ciprofibrate
antibacterial
1991
27 (324)
antibacterial
1995
31 (339)
antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antiarthritic antihypertensive
1987 1985 1992 1989 1992 2010 1983 1987 1992 2008 1987 1987 1999 1983
23 (330) 21 (325) 28 (328) 25 (310) 28 (328) 46 (453) 19 (316) 23 (330) 28 (329) 44 (589) 23 (331) 23 (331) 35 (335) 19 (317)
contraception immunomodulator antihypercholesterolemic irritable bowel syndrome antiallergy
1991 1991 1997 2008 1987
27 (324) 27 (325) 33 (331) 44 (592) 23 (331)
infertility anticancer antixerostomia
1999 2003 2000
35 (336) 39 (272) 36 (299)
gallstones Parkinson’s disease cognition enhancer antihypercholesterolemic antiarrhythmic antiasthma antihypertensive antiviral antihypertensive antithrombotic antispasmodic hyperparathyroidism antihypertensive gastroprokinetic anxiolytic antihypercholesterolemic
1983 1999 1990 2008 1985 2005 1988 1996 1990 1988 1985 2004 1995 1990 1993 1985
19 (317) 35 (336) 26 (300) 44 (594) 21 (325) 41 (443) 24 (299) 32 (306) 26 (301) 24 (299) 21 (326) 40 (451) 31 (339) 26 (301) 29 (334) 21 (326)
585
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
ciprofloxacin cisapride cisatracurium besilate citalopram cladribine clarithromycin clevidipine clevudine clobenoside cloconazole hydrochloride clodronate disodium clofarabine clopidogrel hydrogensulfate cloricromen clospipramine hydrochloride colesevelam hydrochloride colestimide colforsin daropate hydrochloride conivaptan corifollitropin alfa crizotinib crofelemer crotelidae polyvalent immune fab cyclosporine cytarabine ocfosfate dabigatran etexilate dalfampridine dalfopristin dapagliflozin dapiprazole hydrochloride dapoxetine daptomycin darifenacin
antibacterial gastroprokinetic muscle relaxant antidepressant anticancer antibacterial antihypertensive antiviral antiinflammatory antifungal
1986 1988 1995 1989 1993 1990 2008 2007 1988 1986
22 24 31 25 29 26 44 43 24 22
calcium regulation anticancer antithrombotic
1986 2005 1998
22 (319) 41 (444) 34 (320)
antithrombotic antipsychotic
1991 1991
27 (325) 27 (325)
antihypercholesterolemic
2000
36 (300)
antihypercholesterolemic congestive heart failure
1999 1999
35 (337) 35 (337)
hyponatremia infertility anticancer antidiarrheal antidote, snake venom poisoning immunosuppressant anticancer anticoagulant multiple sclerosis antibacterial antidiabetic antiglaucoma
2006 2010 2011 2012 2001
42 46 47 48 37
(514) (455) (525) (494) (263)
1983 1993 2008 2010 1999 2012 1987
19 29 44 46 35 48 23
(317) (335) (598) (458) (338) (495) (332)
premature ejaculation antibacterial urinary tract/bladder disorders antiviral anticancer myelodysplastic syndromes iron chelation therapy
2009 2003 2005
45 (488) 39 (272) 41 (445)
2006 2006 2006 1995
42 42 42 31
darunavir dasatinib decitabine defeiprone
(318) (299) (340) (311) (335) (302) (596) (466) (300) (318)
(515) (517) (519) (340)
586
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
deferasirox defibrotide deflazacort degarelix acetate delapril delavirdine mesylate denileukin diftitox denopamine denosumab deprodone propionate desflurane desloratadine desvenlafaxine dexfenfluramine dexibuprofen dexlansoprazole dexmedetomidine hydrochloride dexmethylphenidate hydrochloride dexrazoxane dezocine diacerein didanosine dilevalol diquafosol tetrasodium dirithromycin disodium pamidronate divistyramine docarpamine docetaxel dofetilide dolasetron mesylate donepezil hydrochloride dopexamine doripenem dornase alfa dorzolamide hydrochloride dosmalfate doxacurium chloride doxazosin mesylate doxefazepam doxercalciferol
iron chelation therapy antithrombotic antiinflammatory anticancer antihypertensive antiviral anticancer congestive heart failure osteoporosis antiinflammatory anesthetic antiallergy antidepressant antiobesity antiinflammatory antiulcer sleep disorders
2005 1986 1986 2009 1989 1997 1999 1988 2010 1992 1992 2001 2008 1997 1994 2009 2000
41 (446) 22 (319) 22 (319) 45 (490) 25 (311) 33 (331) 35 (338) 24 (300) 46 (459) 28 (329) 28 (329) 37 (264) 44 (600) 33 (332) 30 (298) 45 (492) 36 (301)
attention deficit hyperactivity disorder cardioprotective analgesic antiinflammatory antiviral antihypertensive ophthalmologic (dry eye) antibacterial osteoporosis antihypercholesterolemic congestive heart failure anticancer antiarrhythmic antiemetic Alzheimer’s disease
2002
38 (352)
1992 1991 1985 1991 1989 2010 1993 1989 1984 1994 1995 2000 1998 1997
28 (330) 27 (326) 21 (326) 27 (326) 25 (311) 46 (462) 29 (336) 25 (312) 20 (317) 30 (298) 31 (341) 36 (301) 34 (321) 33 (332)
congestive heart failure antibacterial cystic fibrosis antiglaucoma
1989 2005 1994 1995
25 (312) 41 (448) 30 (298) 31 (341)
antiulcer muscle relaxant antihypertensive anxiolytic hyperparathyroidism
2000 1991 1988 1985 1999
36 (302) 27 (326) 24 (300) 21 (326) 35 (339)
587
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
doxifluridine doxofylline dronabinol dronedarone drospirenone drotrecogin alfa droxicam droxidopa duloxetine dutasteride duteplase ebastine eberconazole ebrotidine ecabet sodium ecallantide eculizumab edaravone edoxaban efalizumab efavirenz efonidipine egualen sodium eldecalcitol eletriptan eltrombopag emedastine difumarate emorfazone emtricitabine enalapril maleate enalaprilat encainide hydrochloride enfuvirtide enocitabine enoxacin enoxaparin enoximone enprostil entacapone entecavir enzalutamide epalrestat eperisone hydrochloride
anticancer antiasthma antiemetic antiarrhythmic contraception antisepsis antiinflammatory Parkinson’s disease antidepressant benign prostatic hyperplasia anticoagulant antiallergy antifungal antiulcer antiulcer angioedema, hereditary hemoglobinuria neuroprotective antithrombotic antipsoriasis antiviral antihypertensive antiulcer osteoporosis antimigraine antithrombocytopenic antiallergy analgesic antiviral antihypertensive antihypertensive antiarrhythmic
1987 1985 1986 2009 2000 2001 1990 1989 2004 2002 1995 1990 2005 1997 1993 2009 2007 2001 2011 2003 1998 1994 2000 2011 2001 2009 1993 1984 2003 1984 1987 1987
23 21 22 45 36 37 26 25 40 38 31 26 41 33 29 46 43 37 47 39 34 30 36 47 37 45 29 20 39 20 23 23
(332) (327) (319) (495) (302) (265) (302) (312) (452) (353) (342) (302) (449) (333) (336) (464) (468) (265) (527) (274) (321) (299) (303) (529) (266) (497) (336) (317) (274) (317) (332) (333)
antiviral anticancer antibacterial anticoagulant congestive heart failure antiulcer Parkinson’s disease antiviral anticancer antidiabetic muscle relaxant
2003 1983 1986 1987 1988 1985 1998 2005 2012 1992 1983
39 19 22 23 24 21 34 41 48 28 19
(275) (318) (320) (333) (301) (327) (322) (450) (497) (330) (318)
588
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
epidermal growth factor epinastine epirubicin hydrochloride eplerenone epoprostenol sodium eprosartan eptazocine hydrobromide eptilfibatide erdosteine eribulin mesylate erlotinib ertapenem sodium erythromycin acistrate erythropoietin escitalopram oxolate eslicarbazepine acetate esmolol hydrochloride esomeprazole magnesium eszopiclone ethyl icosapentate etizolam etodolac etoricoxibe etravirine everolimus exemestane exenatide exifone ezetimibe factor VIIa factor VIII fadrozole hydrochloride falecalcitriol famciclovir famotidine fasudil hydrochloride febuxostat felbamate felbinac felodipine fenbuprol fenoldopam mesylate
wound healing agent antiallergy anticancer
1987 1994 1984
23 (333) 30 (299) 20 (318)
antihypertensive antiplatelet antihypertensive analgesic
2003 1983 1997 1987
39 (276) 19 (318) 33 (333) 23 (334)
antithrombotic expectorant anticancer anticancer antibacterial antibacterial hematopoietic antidepressant anticonvulsant antiarrhythmic antiulcer
1999 1995 2010 2004 2002 1988 1988 2002 2009 1987 2000
35 (340) 31 (342) 46 (465) 40 (454) 38 (353) 24 (301) 24 (301) 38 (354) 45 (498) 23 (334) 36 (303)
sleep disorders antithrombotic anxiolytic antiinflammatory antiarthritic antiviral immunosuppressant anticancer antidiabetic cognition enhancer antihypercholesterolemic haemophilia hemostatic anticancer hyperparathyroidism antiviral antiulcer amyotrophic lateral sclerosis gout anticonvulsant antiinflammatory antihypertensive biliary tract dysfunction antihypertensive
2005 1990 1984 1985 2002 2008 2004 2000 2005 1988 2002 1996 1992 1995 2001 1994 1985 1995 2009 1993 1986 1988 1983 1998
41 (451) 26 (303) 20 (318) 21 (327) 38 (355) 44 (602) 40 (455) 36 (304) 41 (452) 24 (302) 38 (355) 32 (307) 28 (330) 31 (342) 37 (266) 30 (300) 21 (327) 31 (343) 45 (501) 29 (337) 22 (320) 24 (302) 19 (318) 34 (322)
589
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
fenticonazole nitrate fesoterodine
antifungal urinary tract/bladder disorders antiallergy antibacterial immunostimulant benign prostatic hyperplasia multiple sclerosis antiinflammatory antibacterial antibacterial congestive heart failure antifungal anticancer antidote, benzodiazepine overdose antiinflammatory antidepressant
1987 2008
23 (334) 44 (604)
1996 2011 1991 1992 2010 1984 1992 1988 1992 1988 1991 1987
32 47 27 28 46 20 28 24 28 24 27 23
1987 1986
23 (335) 22 (320)
analgesic antibacterial
1985 1997
21 (328) 33 (333)
anticancer anxiolytic antiallergy antiinflammatory anxiolytic antifungal antiasthma antihypercholesterolemic antidepressant infertility infertility antidote, ethylene glycol poisoning antiviral antithrombotic anticancer chronic obstructive pulmonary disorder antiviral antiemetic
1983 1984 2007 1990 1986 1995 1988 1994 1983 1996 1996 1998
19 20 43 26 22 31 24 30 19 32 32 34
(318) (318) (469) (303) (320) (343) (303) (300) (319) (307) (308) (323)
1998 2002 1993 1986
34 38 29 22
(323) (356) (337) (321)
2003 2008
39 (277) 44 (606)
antiviral antifungal
1989 2004
25 (313) 40 (457)
fexofenadine fidaxomicin filgrastim finasteride fingolimod fisalamine fleroxacin flomoxef sodium flosequinan fluconazole fludarabine phosphate flumazenil flunoxaprofen fluoxetine hydrochloride flupirtine maleate flurithromycin ethylsuccinate flutamide flutazolam fluticasone furoate fluticasone propionate flutoprazepam flutrimazole flutropium bromide fluvastatin fluvoxamine maleate follitropin alfa follitropin beta fomepizole fomivirsen sodium fondaparinux sodium formestane formoterol fumarate fosamprenavir fosaprepitant dimeglumine foscarnet sodium fosfluconazole
(307) (531) (327) (331) (468) (318) (331) (302) (331) (303) (327) (335)
590
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
fosfosal fosinopril sodium fosphenytoin sodium fotemustine fropenam frovatriptan fudosteine fulveristrant gabapentin gabapentin Enacarbil gadoversetamide gallium nitrate gallopamil hydrochloride galsulfase ganciclovir ganirelix acetate garenoxacin gatilfloxacin gefitinib gemcitabine hydrochloride gemeprost gemifloxacin gemtuzumab ozogamicin gestodene gestrinone glatiramer acetate glimepiride glucagon, rDNA GMDP golimumab goserelin granisetron hydrochloride guanadrel sulfate gusperimus halobetasol propionate halofantrine halometasone histrelin hydrocortisone aceponate hydrocortisone butyrate
analgesic antihypertensive anticonvulsant anticancer antibacterial antimigraine expectorant anticancer anticonvulsant restless leg syndrome diagnostic calcium regulation antianginal
1984 1991 1996 1989 1997 2002 2001 2002 1993 2011 2000 1991 1983
20 (319) 27 (328) 32 (308) 25 (313) 33 (334) 38 (357) 37 (267) 38 (357) 29 (338) 47 (533) 36 (304) 27 (328) 19 (3190)
mucopolysaccharidosis VI antiviral infertility antibacterial antibacterial anticancer anticancer
2005 1988 2000 2007 1999 2002 1995
41 (453) 24 (303) 36 (305) 43 (471) 35 (340) 38 (358) 31 (344)
abortifacient antibacterial anticancer
1983 2004 2000
19 (319) 40 (458) 36 (306)
contraception contraception multiple sclerosis antidiabetic antidiabetic immunostimulant antiinflammatory hormone therapy antiemetic
1987 1986 1997 1995 1993 1996 2009 1987 1991
23 (335) 22 (321) 33 (334) 31 (344) 29 (338) 32 (308) 45 (503) 23 (336) 27 (329)
antihypertensive immunosuppressant antiinflammatory antimalarial antiinflammatory precocious puberty antiinflammatory
1983 1994 1991 1988 1983 1993 1988
19 (319) 30 (300) 27 (329) 24 (304) 19 (320) 29 (338) 24 (304)
antiinflammatory
1983
19 (320)
591
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
ibandronic acid ibopamine hydrochloride ibritunomab tiuxetan ibudilast ibutilide fumarate icatibant idarubicin hydrochloride idebenone idursulfase
osteoporosis congestive heart failure
1996 1984
32 (309) 20 (319)
anticancer antiasthma antiarrhythmic angioedema, hereditary anticancer
2002 1989 1996 2008 1990
38 25 32 44 26
nootropic mucopolysaccharidosis II (Hunter syndrome) antiarthritic antiplatelet anticancer urinary tract/bladder disorders antihypertensive Gaucher’s disease antibacterial antiviral osteoporosis chronic obstructive pulmonary disease antidepressant nootropic
1986 2006
22 (321) 42 (520)
2011 1992 2001 2007
47 28 37 43
(535) (332) (267) (472)
1993 1994 1985 1997 1997 2009
29 30 21 33 33 45
(339) (301) (328) (335) (335) (505)
1983 1988
19 (320) 24 (304)
antiviral antiemetic antithrombotic antiviral anticancer antidiabetic antiviral immunostimulant multiple sclerosis multiple sclerosis antiinflammatory anticancer anticancer diagnostic anticancer osteoporosis antihypertensive anticancer
1996 2004 1984 2003 2012 1996 1997 1991 1996 1993 1989 1992 1989 2000 2011 1989 1997 1994
32 40 20 39 48 32 33 27 32 29 25 28 25 36 47 25 33 30
iguratimod iloprost imatinib mesylate imidafenacin imidapril hydrochloride imiglucerase imipenem/cilastatin imiquimod incadronic acid indacaterol indalpine indeloxazine hydrochloride indinavir sulfate indisetron indobufen influenza virus (live) ingenol mebutate insulin lispro interferon alfacon-1 interferon gamma-1b interferon, b-1a interferon, b-1b interferon, gamma interferon, gamma-1 interleukin-2 ioflupane ipilimumab ipriflavone irbesartan irinotecan
(359) (313) (309) (608) (303)
(310) (459) (319) (277) (499) (310) (336) (329) (311) (339) (314) (332) (314) (306) (537) (314) (336) (301)
592
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
irsogladine isepamicin isofezolac isoxicam isradipine itopride hydrochloride itraconazole ivabradine ivacaftor ivermectin ixabepilone ketanserin ketorolac tromethamine kinetin
antiulcer antibacterial antiinflammatory antiinflammatory antihypertensive gastroprokinetic antifungal antianginal cystic fibrosis antiparasitic anticancer antihypertensive analgesic
1989 1988 1984 1983 1989 1995 1988 2006 2012 1987 2007 1985 1990
25 (315) 24 (305) 20 (319) 19 (320) 25 (315) 31 (344) 24 (305) 42 (522) 48 (501) 23 (336) 43 (473) 21 (328) 26 (304)
dermatologic, skin photodamage antihypertensive anticonvulsant antiulcer antiviral anticonvulsant antiarrhythmic antiviral antifungal growth disorders antiulcer anticancer mucopolysaccharidosis I antiglaucoma antiarthritic myelodysplastic syndromes, multiple myeloma antibacterial
1999
35 (341)
1991 2008 2000 1995 1990 2002 2010 1994 1995 1992 2007 2003 1996 1998 2006
27 (330) 44 (610) 36 (307) 31 (345) 26 (304) 38 (360) 46 (470) 30 (302) 31 (345) 28 (332) 43 (475) 39 (278) 32 (311) 34 (324) 42 (523)
1987
23 (336)
immunostimulant anticoagulant antihypertensive anticancer hormone therapy cognition enhancer
1986 1997 1997 1996 1984 1986
22 (322) 33 (336) 33 (337) 32 (311) 20 (319) 22 (322)
antiasthma
1999
35 (341)
anticonvulsant antiglaucoma
2000 1985
36 (307) 21 (328)
lacidipine lacosamide lafutidine lamivudine lamotrigine landiolol laninamivir octanoate lanoconazole lanreotide acetate lansoprazole lapatinib laronidase latanoprost lefunomide lenalidomide lenampicillin hydrochloride lentinan lepirudin lercanidipine letrazole leuprolide acetate levacecarnine hydrochloride levalbuterol hydrochloride levetiracetam levobunolol hydrochloride
593
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
levobupivacaine hydrochloride levocabastine hydrochloride levocetirizine levodropropizine levofloxacin levosimendan lidamidine hydrochloride limaprost linaclotide linagliptin linezolid liraglutide liranaftate lisdexamfetamine
anesthetic
2000
36 (308)
antiallergy
1991
27 (330)
antiallergy antitussive antibacterial congestive heart failure antidiarrheal
2001 1988 1993 2000 1984
37 24 29 36 20
(268) (305) (340) (308) (320)
antithrombotic irritable bowel syndrome antidiabetic antibacterial antidiabetic antifungal attention deficit hyperactivity disorder antihypertensive antiinflammatory antiallergy
1988 2012 2011 2000 2009 2000 2007
24 48 47 36 45 36 43
(306) (502) (540) (309) (507) (309) (477)
1987 1986 1992
23 (337) 22 (322) 28 (333)
antibacterial antimigraine
1989 1999
25 (315) 35 (342)
antihypercholersteremic anticancer antiviral sleep disorders congestive heart failure
2012 1987 2000 1983 1996
48 23 36 19 32
antibacterial antiallergy antiobesity
1992 1988 2012
28 (333) 24 (306) 48 (506)
antiinflammatory antihypertensive antiallergy antihypercholesterolemic antiinflammatory constipation antifungal antiinflammatory antipsychotic
1997 1994 1998 1987 1986 2006 2005 2005 2010
33 30 34 23 22 42 41 41 46
Lyme disease
1999
35 (342)
lisinopril lobenzarit sodium lodoxamide tromethamine lomefloxacin lomerizine hydrochloride lomitapide mesylate lonidamine lopinavir loprazolam mesylate loprinone hydrochloride loracarbef loratadine lorcaserin hydrochloride lornoxicam losartan loteprednol etabonate lovastatin loxoprofen sodium lulbiprostone luliconazole lumiracoxib lurasidone hydrochloride Lyme disease vaccine
(504) (337) (310) (321) (312)
(337) (302) (324) (337) (322) (525) (454) (455) (473)
594
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
mabuterol hydrochloride malotilate manidipine hydrochloride maraviroc masoprocol maxacalcitol mebefradil hydrochloride medifoxamine fumarate mefloquine hydrochloride meglutol melinamide meloxicam mepixanox meptazinol hydrochloride meropenem metaclazepam metapramine methylnaltrexone bromide mexazolam micafungin mifamurtide mifepristone miglitol miglustat milnacipran milrinone miltefosine minodronic acid miokamycin mirabegron
antiasthma
1986
22 (323)
hepatoprotective antihypertensive
1985 1990
21 (329) 26 (304)
antiviral anticancer hyperparathyroidism antihypertensive
2007 1992 2000 1997
43 (478) 28 (333) 36 (310) 33 (338)
antidepressant antimalarial
1986 1985
22 (323) 21 (329)
antihypercholesterolemic antihypercholesterolemic antiarthritic respiratory stimulant analgesic
1983 1984 1996 1984 1983
19 (321) 20 (320) 32 (312) 20 (320) 19 (321)
antibacterial anxiolytic antidepressant constipation
1994 1987 1984 2008
30 (303) 23 (338) 20 (320) 44 (612)
anxiolytic antifungal anticancer abortifacient antidiabetic Gaucher’s disease antidepressant congestive heart failure anticancer osteoporosis antibacterial urinary tract/bladder disorders antidepressant antiulcer antidiabetic anticancer
1984 2002 2009 1988 1998 2003 1997 1989 1993 2009 1985 2011
20 (321) 38 (360) 46 (476) 24 (306) 34 (325) 39 (279) 33 (338) 25 (316) 29 (340) 45 (509) 21 (329) 47 (542)
1994 1985 2004 1984
30 (303) 21 (329) 40 (460) 20 (321)
muscle relaxant hepatoprotective antiallergy
1992 1999 1998
28 (334) 35 (343) 34 (325)
mirtazapine misoprostol mitiglinide mitoxantrone hydrochloride mivacurium chloride mivotilate mizolastine
595
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
mizoribine moclobemide modafinil moexipril hydrochloride mofezolac mogamulizumab mometasone furoate montelukast sodium moricizine hydrochloride mosapride citrate moxifloxacin hydrochloride moxonidine mozavaptan mupirocin muromonab-CD3 muzolimine mycophenolate mofetil mycophenolate sodium nabumetone nadifloxacin nafamostat mesylate nafarelin acetate naftifine hydrochloride naftopidil
immunosuppressant antidepressant sleep disorders antihypertensive
1984 1990 1994 1995
20 26 30 31
(321) (305) (303) (346)
analgesic anticancer antiinflammatory antiasthma antiarrhythmic
1994 2012 1987 1998 1990
30 48 23 34 26
(304) (507) (338) (326) (305)
gastroprokinetic antibacterial
1998 1999
34 (326) 35 (343)
antihypertensive hyponatremia antibacterial immunosuppressant diuretic immunosuppressant immunosuppressant antiinflammatory antibacterial pancreatitis hormone therapy antifungal urinary tract/bladder disorders pruritus
1991 2006 1985 1986 1983 1995 2003 1985 1993 1986 1990 1984 1999
27 42 21 22 19 31 39 21 29 22 26 20 35
2009
45 (510)
addiction, opioids
1995
31 (347)
addiction, opioids
1984
20 (322)
antimigraine
1997
33 (339)
leukopenia multiple sclerosis antidiabetic antiemetic antihypertensive anticancer antiallergy antidepressant anticancer
1994 2004 1999 1994 1997 1995 1986 1994 2006
30 40 35 30 33 31 22 30 42
nalfurafine hydrochloride nalmefene hydrochloride naltrexone hydrochloride naratriptan hydrochloride nartograstim natalizumab nateglinide nazasetron nebivolol nedaplatin nedocromil sodium nefazodone nelarabine
(330) (527) (330) (323) (321) (346) (279) (330) (340) (323) (306) (321) (344)
(304) (462) (344) (305) (339) (347) (324) (305) (528)
596
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
nelfinavir mesylate neltenexine nemonapride nepafenac neridronic acide nesiritide neticonazole hydrochloride nevirapine nicorandil nif ekalant hydrochloride nilotinib nilutamide nilvadipine nimesulide nimodipine nimotuzumab nipradilol nisoldipine nitisinone nitrefazole nitrendipine nizatidine nizofenzone nomegestrol acetate norelgestromin norfloxacin norgestimate OCT-43 octreotide ofatumumab ofloxacin olanzapine olimesartan Medoxomil olopatadine hydrochloride omacetaxine mepesuccinate omalizumab allergic omeprazole ondansetron hydrochloride OP-1 orlistat
antiviral cystic fibrosis antipsychotic antiinflammatory calcium regulation congestive heart failure antifungal
1997 1993 1991 2005 2002 2001 1993
33 (340) 29 (341) 27 (331) 41 (456) 38 (361) 37 (269) 29 (341)
antiviral antianginal antiarrhythmic
1996 1984 1999
32 (313) 20 (322) 35 (344)
anticancer anticancer antihypertensive antiinflammatory cerebral vasodilator anticancer antihypertensive antihypertensive antityrosinaemia addiction, alcohol antihypertensive antiulcer nootropic contraception contraception antibacterial contraception anticancer growth disorders anticancer antibacterial antipsychotic antihypertensive antiallergy
2007 1987 1989 1985 1985 2006 1988 1990 2002 1983 1985 1987 1988 1986 2002 1983 1986 1999 1988 2009 1985 1996 2002 1997
43 (480) 23 (338) 25 (316) 21 (330) 21 (330) 42 (529) 24 (307) 26 (306) 38 (361) 19 (322) 21 (331) 23 (339) 24 (307) 22 (324) 38 (362) 19 (322) 22 (324) 35 (345) 24 (307) 45 (512) 21 (331) 32 (313) 38 (363) 33 (340)
anticancer
2012
48 (510)
antiasthma antiulcer antiemetic
2003 1988 1990
39 (280) 24 (308) 26 (306)
osteoinductor antiobesity
2001 1998
37 (269) 34 (327)
597
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
ornoprostil osalazine sodium oseltamivir phosphate oxaliplatin oxaprozin oxcarbazepine oxiconazole nitrate oxiracetam oxitropium bromide ozagrel sodium paclitaxal palifermin paliperidone palonosetron panipenem/ betamipron carbapenem panitumumab pantoprazole sodium parecoxib sodium paricalcitol parnaparin sodium paroxetine pasireotide pazopanib pazufloxacin pefloxacin mesylate pegademase bovine pegaptanib
antiulcer antiinflammatory antiviral anticancer antiinflammatory anticonvulsant antifungal cognition enhancer antiasthma antithrombotic anticancer mucositis antipsychotic antiemetic antibacterial
1987 1986 1999 1996 1983 1990 1983 1987 1983 1988 1993 2005 2007 2003 1994
23 22 35 32 19 26 19 23 19 24 29 41 43 39 30
(339) (324) (346) (313) (322) (307) (322) (339) (323) (308) (342) (461) (482) (281) (305)
anticancer antiulcer analgesic hyperparathyroidism anticoagulant antidepressant Cushing’s Disease anticancer antibacterial antibacterial immunostimulant ophthalmologic (macular degeneration) anticancer hematopoietic growth disorders anticancer antiasthma antiviral anticancer antiviral anticonvulsant Parkinson’s disease antihypertensive antipsychotic
2006 1995 2002 1998 1993 1991 2012 2009 2002 1985 1990 2005
42 30 38 34 29 27 48 45 38 21 26 41
(531) (306) (364) (327) (342) (331) (512) (514) (364) (331) (307) (458)
1994 2012 2003 2004 1991 1996 1992 2010 2012 1988 1988 2001
30 48 39 40 27 32 28 46 48 24 24 37
(306) (514) (281) (463) (331) (314) (334) (477) (516) (308) (309) (270)
anticancer antithrombotic
2012 1987
48 (517) 23 (340)
pegaspargase peginesatide pegvisomant pemetrexed pemirolast potassium penciclovir pentostatin peramivir perampanel pergolide mesylate perindopril perospirone hydrochloride pertuzumab picotamide
598
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
pidotimod piketoprofen pilsicainide hydrochloride pimaprofen pimecrolimus pimobendan pinacidil pioglitazone hydrochloride pirarubicin pirfenidone pirmenol piroxicam cinnamate pitavastatin pivagabine pixantrone dimaleate plaunotol plerixafor hydrochloride polaprezinc ponatinib porfimer sodium posaconazole pralatrexate pramipexole hydrochloride pramiracetam sulfate pramlintide pranlukast prasugrel pravastatin prednicarbate pregabalin prezatide copper acetate progabide promegestrone propacetamol hydrochloride propagermanium propentofylline propionate propiverine hydrochloride propofol
immunostimulant antiinflammatory antiarrhythmic
1993 1984 1991
29 (343) 20 (322) 27 (332)
antiinflammatory immunosuppressant congestive heart failure antihypertensive antidiabetic
1984 2002 1994 1987 1999
20 (322) 38 (365) 30 (307) 23 (340) 35 (346)
anticancer pulmonary fibrosis, idiopathic antiarrhythmic antiinflammatory antihypercholesterolemic antidepressant anticancer antiulcer stem cell mobilizer
1988 2008 1994 1988 2003 1997 2012 1987 2009
24 (309) 44 (614) 30 (307) 24 (309) 39 (282) 33 (341) 48 (519) 23 (340) 45 (515)
antiulcer anticancer anticancer antifungal anticancer Parkinson’s disease
1994 2012 1993 2006 2009 1997
30 (307) 48 (521) 29 (343) 42 (532) 45 (517) 33 (341)
cognition enhancer antidiabetic antiasthma antiplatelet antihypercholesterolemic antiinflammatory anticonvulsant wound healing agent anticonvulsant contraception analgesic
1993 2005 1995 2009 1989 1986 2004 1996 1985 1983 1986
29 (343) 41 (460) 31 (347) 45 (519) 25 (316) 22 (325) 40 (464) 32 (314) 21 (331) 19 (323) 22 (325)
antiviral cerebral vasodilator
1994 1988
30 (308) 24 (310)
urinary tract/bladder disorders anesthetic
1992
28 (335)
1986
22 (325)
599
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
prulifloxacin pumactant quazepam quetiapine fumarate quinagolide quinapril quinf amideamebicide quinupristin rabeprazole sodium radotinib raloxifene hydrochloride raltegravir raltitrexed ramatroban ramelteon ramipril ramosetron ranibizumab
antibacterial respiratory distress syndrome sleep disorders antipsychotic hyperprolactinemia antihypertensive antiparasitic antibacterial antiulcer anticancer osteoporosis
2002 1994 1985 1997 1994 1989 1984 1999 1998 2012 1998
38 30 21 33 30 25 20 35 34 48 34
(366) (308) (332) (341) (309) (317) (322) (338) (328) (523) (328)
antiviral anticancer antiallergy sleep disorders antihypertensive antiemetic ophthalmologic (macular degeneration) anticancer antiulcer
2007 1996 2000 2005 1989 1996 2006
43 32 36 41 25 32 42
(484) (315) (311) (462) (317) (315) (534)
1987 1995
23 (341) 31 (348)
antianginal muscle relaxant Parkinson’s disease antiulcer antidepressant anticancer analgesic
2006 1999 2005 1990 1997 2012 1996
42 35 41 26 33 48 32
antipsychotic
1990
26 (308)
antidiabetic antiallergy antibacterial antithrombotic anticonvulsant anticoagulant antibacterial antibacterial antibacterial antibacterial sleep disorders antihypertensive
1998 1987 2007 1996 2011 1993 1992 1988 1985 1987 1989 1988
34 23 43 32 47 29 28 24 21 23 25 24
ranimustine ranitidine bismuth citrate ranolazine rapacuronium bromide rasagiline rebamipide reboxetine regorafenib remifentanil hydrochloride remoxipride hydrochloride repaglinide repirinast retapamulin reteplase retigabine reviparin sodium rifabutin rifapentine rifaximin rifaximin rilmazafone rilmenidine
(535) (347) (464) (308) (342) (524) (316)
(329) (341) (486) (316) (544) (344) (335) (310) (332) (341) (317) (310)
600
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
rilonacept
genetic autoinflammatory syndromes antiviral amyotrophic lateral sclerosis antiviral
2008
44 (615)
2011 1996 1987
47 (546) 32 (316) 23 (342)
antiinflammatory antiobesity osteoporosis antipsychotic antiviral anticoagulant Alzheimer’s disease antimigraine muscle relaxant antiarthritic chronic obstructive pulmonary disorder antibacterial anticancer antithrombocytopenic immunostimulant antihypercholesterolemic Parkinson’s disease
1995 2006 1998 1993 1996 2008 1997 1998 1994 1999 2010
31 (348) 42 (537) 34 (330) 29 (344) 32 (317) 44 (617) 33 (342) 34 (330) 30 (309) 35 (347) 46 (480)
1986 2009 2008 1991 1986 1996
22 (325) 46 (482) 44 (619) 27 (332) 22 (326) 32 (317)
anesthetic antiulcer antidiabetic antihypercholesterolemic Parkinson’s disease antiulcer
1996 1985 1999 2003 2006 1986
32 (318) 21 (332) 35 (348) 39 (283) 42 (538) 22 (326)
antiulcer anticonvulsant antibacterial
1987 2007 1992
23 (342) 43 (488) 28 (335)
antiallergy anticancer antibacterial antiasthma
2003 2011 1989 1990
39 (284) 47 (548) 25 (318) 26 (308)
phenylketouria
1992
28 (336)
antiviral immunostimulant
1995 1991
31 (349) 27 (332)
rilpivirine riluzole rimantadine hydrochloride rimexolone rimonabant risedronate sodium risperidone ritonavir rivaroxaban rivastigmin rizatriptan benzoate rocuronium bromide rofecoxib roflumilast rokitamycin romidepsin romiplostim romurtide ronafibrate ropinirole hydrochloride ropivacaine rosaprostol rosiglitazone maleate rosuvastatin rotigotine roxatidine acetate hydrochloride roxithromycin rufinamide rufloxacin hydrochloride rupatadine fumarate ruxolitinib RV-11 salmeterol hydroxynaphthoate sapropterin hydrochloride saquinavir mesvlate sargramostim
601
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
sarpogrelate hydrochloride saxagliptin schizophyllan seratrodast sertaconazole nitrate sertindole setastine hydrochloride setiptiline setraline hydrochloride sevoflurane sibutramine sildenafil citrate silodosin
antithrombotic
1993
29 (344)
antidiabetic immunostimulant antiasthma antifungal antipsychotic antiallergy antidepressant antidepressant anesthetic antiobesity male sexual dysfunction urinary tract/bladder disorders antihypercholesterolemic anticancer antibacterial antidiabetic pulmonary hypertension antiinflammatory anticancer anticancer urinary tract/bladder disorders antiulcer urinary tract/bladder disorders growth disorders growth disorders growth disorders anticancer antiviral antibacterial antihypertensive antiulcer antiviral osteoporosis antidote, lead poisoning analgesic neuromuscular blockade, reversal antibacterial antifungal antibacterial
2009 1985 1995 1992 1996 1987 1989 1990 1990 1998 1998 2006
45 22 31 28 32 23 25 26 26 34 34 42
(521) (326) (349) (336) (318) (342) (318) (309) (309) (331) (331) (540)
1988 2010 2008 2006 2006 2002 1999 1994 1983
24 46 44 42 42 38 35 30 19
(311) (484) (621) (541) (543) (366) (348) (310) (323)
1984 2004
20 (323) 40 (466)
1994 1994 1987 2005 1993 1993 1995 1987 1994 2004 1991 1983 2008
30 30 23 41 29 29 31 23 30 40 27 19 44
1986 1985 1987
22 (326) 21 (332) 23 (343)
simvastatin sipuleucel-t sitafloxacin hydrate sitagliptin sitaxsentan sivelestat SKI-2053R sobuzoxane sodium cellulose phosphate sofalcone solifenacin somatomedin-1 somatotropin somatropin sorafenib sorivudine sparfloxacin spirapril hydrochloride spizofurone stavudine strontium ranelate succimer sufentanil sugammadex sulbactam sodium sulconizole nitrate sultamycillin tosylate
(310) (310) (343) (466) (345) (345) (349) (343) (311) (466) (333) (323) (623)
602
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
sumatriptan succinate sunitinib suplatast tosilate suprofen surfactant TA tacalcitol tacrine hydrochloride tacrolimus tadalafil tafamidis tafluprost talaporfin sodium talipexole taltirelin tamibarotene tamsulosin hydrochloride tandospirone tapentadol hydrochloride tasonermin tazanolast tazarotene tazobactam sodium teduglutide tegaserod maleate teicoplanin telaprevir telavancin telbivudine telithromycin telmesteine telmisartan temafloxacin hydrochloride temocapril temocillin disodium temoporphin temozolomide temsirolimus teneligliptin tenofovir disoproxil fumarate tenoxicam teprenone
antimigraine anticancer antiallergy analgesic respiratory surfactant antipsoriasis Alzheimer’s disease immunosuppressant male sexual dysfunction neurodegeneration antiglaucoma anticancer Parkinson’s disease neurodegeneration anticancer benign prostatic hyperplasia
1991 2006 1995 1983 1987 1993 1993 1993 2003 2011 2008 2004 1996 2000 2005 1993
27 (333) 42 (544) 31 (350) 19 (324) 23 (344) 29 (346) 29 (346) 29 (347) 39 (284) 47 (550) 44 (625) 40 (469) 32 (318) 36 (311) 41 (467) 29 (347)
anxiolytic analgesic
1996 2009
32 (319) 45 (523)
anticancer antiallergy antipsoriasis antibacterial short bowel syndrome irritable bowel syndrome antibacterial antiviral antibacterial antiviral antibacterial expectorant antihypertensive antibacterial
1999 1990 1997 1992 2012 2001 1988 2011 2009 2006 2001 1992 1999 1991
35 (349) 26 (309) 33 (343) 28 (336) 48 (526) 37 (270) 24 (311) 47 (552) 45 (525) 42 (546) 37 (271) 28 (337) 35 (349) 27 (334)
antihypertensive antibacterial anticancer anticancer anticancer antidiabetic antiviral
1994 1984 2002 1999 2007 2012 2001
30 (311) 20 (323) 38 (367) 35 (349) 43 (490) 48 (528) 37 (271)
antiinflammatory antiulcer
1987 1984
23 (344) 20 (323)
603
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
terazosin hydrochloride terbinafine hydrochloride terconazole teriflunomide tertatolol hydrochloride tesamorelin acetate thrombin alfa thrombomodulin (recombinant) thymopentin tiagabine tiamenidine hydrochloride tianeptine sodium tibolone ticagrelor tigecycline tilisolol hydrochloride tiludronate disodium timiperone tinazoline tioconazole tiopronin tiotropium bromide
antihypertensive antifungal
1984 1991
20 (323) 27 (334)
antifungal multiple sclerosis antihypertensive lipodystrophy hemostatic anticoagulant
1983 2012 1987 2010 2008 2008
19 48 23 46 44 44
immunomodulator anticonvulsant antihypertensive
1985 1996 1988
21 (333) 32 (319) 24 (311)
antidepressant hormone therapy antithrombotic antibacterial antihypertensive Paget’s disease antipsychotic nasal decongestant antifungal urolithiasis chronic obstructive pulmonary disorder antiviral antispasmodic antiarrhythmic subarachnoid hemorrhage antithrombotic muscle relaxant
1983 1988 2010 2005 1992 1995 1984 1988 1983 1989 2002
19 24 46 41 28 31 20 24 19 25 38
(324) (312) (488) (468) (337) (350) (323) (312) (324) (318) (368)
2005 1984 1990 1995 1998 1983
41 20 26 31 34 19
(470) (324) (310) (351) (332) (324)
muscle relaxant antiarthritic Parkinson’s disease antidepressant antidiabetic hyponatremia anticonvulsant anticancer
1984 2012 1997 1984 1989 2009 1995 1996
20 48 33 20 25 45 31 32
(324) (532) (343) (324) (319) (528) (351) (320)
diuretic anticancer anticancer
1993 1989 2003
29 (348) 25 (319) 39 (285)
tipranavir tiquizium bromide tiracizine hydrochloride tirilazad mesylate tirofiban hydrochloride tiropramide hydrochloride tizanidine tofacitinib tolcapone toloxatone tolrestat tolvaptan topiramate topotecan hydrochloride torasemide toremifene tositumomab
(324) (530) (344) (486) (627) (628)
604
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
tosufloxacin tosylate trabectedin trandolapril travoprost treprostinil sodium tretinoin tocoferil trientine hydrochloride trimazosin hydrochloride trimegestone trimetrexate glucuronate troglitazone tropisetron trovafloxacin mesylate troxipide ubenimex udenafil ulipristal acetate unoprostone isopropyl ester ustekinumab vadecoxib vaglancirclovir hydrochloride valaciclovir hydrochloride valrubicin valsartan vandetanib vardenafil varenicline vemurafenib venlafaxine vernakalant verteporfin
antibacterial anticancer antihypertensive antiglaucoma antihypertensive antiulcer antidote, copper poisoning antihypertensive
1990 2007 1993 2001 2002 1993 1986 1985
26 (310) 43 (492) 29 (348) 37 (272) 38 (368) 29 (348) 22 (327) 21 (333)
contraception antifungal
2001 1994
37 (273) 30 (312)
antidiabetic antiemetic antibacterial antiulcer immunostimulant male sexual dysfunction contraception antiglaucoma
1997 1992 1998 1986 1987 2005 2009 1994
33 (344) 28 (337) 34 (332) 22 (327) 23 (345) 41 (472) 45 (530) 30 (312)
antipsoriasis antiarthritic antiviral
2009 2002 2001
45 (532) 38 (369) 37 (273)
antiviral
1995
31 (352)
anticancer antihypertensive anticancer male sexual dysfunction addiction, nicotine anticancer antidepressant antiarrhythmic ophthalmologic (macular degeneration) congestive heart failure anticonvulsant antidepressant antidiabetic anticancer anticancer anticancer antidiabetic
1999 1996 2011 2003 2006 2011 1994 2010 2000
35 (350) 32 (320) 47 (555) 39 (286) 42 (547) 47 (556) 30 (312) 46 (491) 36 (312)
1990 1989 2011 2007 2009 1989 2012 1994
26 (310) 25 (319) 47 (558) 43 (494) 46 (493) 25 (320) 48 (534) 30 (313)
vesnarinone vigabatrin vilazodone vildagliptin vinflunine vinorelbine vismodegib voglibose
605
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
voriconazole vorinostat xamoterol fumarate ximelagatran zafirlukast zalcitabine zaleplon zaltoprofen zanamivir ziconotide zidovudine zileuton zinostatin stimalamer ziprasidone hydrochloride zofenopril calcium zoledronate disodium zolpidem hemitartrate zomitriptan zonisamide zopiclone zucapsaicin zuclopenthixol acetate
antifungal anticancer congestive heart failure anticoagulant antiasthma antiviral sleep disorders antiinflammatory antiviral analgesic antiviral antiasthma anticancer antipsychotic
2002 2006 1988 2004 1996 1992 1999 1993 1999 2005 1987 1997 1994 2000
38 42 24 40 32 28 35 29 35 41 23 33 30 36
(370) (549) (312) (470) (321) (338) (351) (349) (352) (473) (345) (344) (313) (312)
antihypertensive osteoporosis sleep disorders antimigraine anticonvulsant sleep disorders analgesic antipsychotic
2000 2000 1988 1997 1989 1986 2010 1987
36 36 24 33 25 22 46 23
(313) (314) (313) (345) (320) (327) (495) (345)
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
abacavir sulfate abarelix abatacept abiraterone acetate acarbose aceclofenac acemannan acetohydroxamic acid
antiviral anticancer antiarthritic anticancer antidiabetic antiinflammatory wound healing agent urinary tract/bladder disorders antidiarrheal antihypercholesterolemic antipsoriasis chronic obstructive pulmonary disorder antiallergy antiinflammatory antiarthritic antibacterial antiviral sleep disorders antiinflammatory ophthalmologic, macular degeneration muscle relaxant Fabry’s disease antihypertensive ophthalmologic (allergic conjunctivitis) antiinflammatory
1999 2004 2006 2011 1990 1992 2001 1983
35 40 42 47 26 28 37 19
(333) (446) (509) (505) (297) (325) (259) (313)
1993 1985 1989 2012
29 21 25 48
(332) (323) (309) (481)
1988 1994 2003 1984 2002 1986 1987 2011
24 30 39 20 38 22 23 47
(295) (296) (267) (315) (348) (315) (325) (507)
1983 2001 1988 2010
19 37 24 46
(313) (259) (296) (444)
1985
21 (323)
antipsoriasis anticancer osteoporosis analgesic antihypertensive Gaucher’s disease Pompe disease antihypertensive anticancer analgesic antimigraine
2003 2001 1993 1983 1988 1991 2006 2007 1999 1983 2000
39 37 29 19 24 27 42 43 35 19 36
acetorphan acipimox acitretin aclidinium bromide acrivastine actarit adalimumab adamantanium bromide adefovir dipivoxil adrafinil AF-2259 aflibercept afloqualone agalsidase alfa alacepril alcaftadine alclometasone dipropionate alefacept alemtuzumab alendronate sodium alfentanil hydrochloride alfuzosin hydrochloride alglucerase alglucosidase alfa aliskiren alitretinoin alminoprofen almotriptan
(267) (260) (332) (314) (296) (321) (511) (461) (333) (314) (295)
579
580
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
alogliptin alosetron hydrochloride alpha-1 antitrypsin alpidem alpiropride alteplase alvimopan ambrisentan amfenac sodium amifostine aminoprofen amisulpride amlexanox amlodipine besylate amorolfine hydrochloride amosulalol ampiroxicam amprenavir amrinone amrubicin hydrochloride amsacrine amtolmetin guacil anagliptin anagrelide hydrochloride anakinra anastrozole angiotensin II anidulafungin aniracetam anti-digoxin polyclonal antibody APD apixaban apraclonidine hydrochloride aprepitant APSAC aranidipine arbekacin arformoterol argatroban arglabin
antidiabetic irritable bowel syndrome emphysema anxiolytic antimigraine antithrombotic post-operative ileus pulmonary hypertension antiinflammatory cytoprotective antiinflammatory antipsychotic antiasthma antihypertensive antifungal
2010 2000 1988 1991 1988 1987 2008 2007 1986 1995 1990 1986 1987 1990 1991
46 (446) 36 (295) 24 (297) 27 (322) 24 (296) 23 (326) 44 (584) 43 (463) 22 (315) 31 (338) 26 (298) 22 (316) 23 (327) 26 (298) 27 (322)
antihypertensive antiinflammatory antiviral congestive heart failure anticancer
1988 1994 1999 1983 2002
24 (297) 30 (296) 35 (334) 19 (314) 38 (349)
anticancer antiinflammatory antidiabetic antithrombotic
1987 1993 2012 1997
23 (327) 29 (332) 48 (483) 33 (328)
antiarthritic anticancer anticancer adjuvant antifungal cognition enhancer antidote, digoxin poisoning
2001 1995 1994 2006 1993 2002
37 (261) 31 (338) 30 (296) 42 (512) 29 (333) 38 (350)
osteoporosis antithrombotic antiglaucoma
1987 2011 1988
23 (326) 47 (509) 24 (297)
antiemetic antithrombotic antihypertensive antibacterial antiasthma antithrombotic anticancer
2003 1987 1996 1990 2007 1990 1999
39 (268) 23 (326) 32 (306) 26 (298) 43 (465) 26 (299) 35 (335)
581
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
aripiprazole armodafinil arotinolol hydrochloride arteether artemisinin asenapine aspoxicillin astemizole astromycin sulfate atazanavir atomoxetine
antipsychotic sleep disorders antihypertensive
2002 2009 1986
38 (350) 45 (478) 22 (316)
antimalarial antimalarial antipsychotic antibacterial antiallergy antibacterial antiviral attention deficit hyperactivity disorder antihypercholesterolemic premature labor antiparasitic antiarthritic male sexual dysfunction anticancer anticancer acne antiallergy
2000 1987 2009 1987 1983 1985 2003 2003
36 23 45 23 19 21 39 39
(296) (327) (479) (328) (314) (324) (269) (270)
1997 2000 1992 1983 2011 2012 2004 1989 1986
33 36 28 19 47 48 40 25 22
(328) (297) (326) (314) (512) (485) (447) (310) (316)
antihypertensive antihypertensive antibacterial diuretic antibacterial antibacterial ulcerative colitis antiasthma antihypertensive
2003 2011 1988 1986 1984 2002 1997 1990 1992
39 47 24 22 20 38 33 26 28
(270) (514) (298) (316) (315) (351) (329) (299) (326)
antihypercholesterolemic antibacterial antiglaucoma
1986 2012 1983
22 (317) 48 (487) 19 (315)
immunosuppressant lupus anticancer antihypertensive
2011 2011 2004 1990
47 47 40 26
antiulcer antihypertensive
1987 1991
23 (328) 27 (322)
atorvastatin calcium atosiban atovaquone auranofin avanafil axitinib azacitidine azelaic acid azelastine hydrochloride azelnidipine azilsartan azithromycin azosemide aztreonam balofloxacin balsalazide disodium bambuterol barnidipine hydrochloride beclobrate bedaquiline befunolol hydrochloride belatacept belimumab belotecan benazepril hydrochloride benexate hydrochloride benidipine hydrochloride
(516) (519) (449) (299)
582
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
beraprost sodium besifloxacin betamethasone butyrate propionate betaxolol hydrochloride betotastine besilate bevacizumab bevantolol hydrochloride bexarotene biapenem bicalutamide bifemelane hydrochloride bilastine bimatoprost binfonazole binifibrate biolimus drug-eluting stent bisantrene hydrochloride bisoprolol fumarate bivalirudin blonanserin boceprevir bopindolol bortezomib bosentan bosutinib brentuximab brimonidine brinzolamide brodimoprin bromfenac sodium brotizolam brovincamine fumarate bucillamine bucladesine sodium budipine budralazine bulaquine bunazosin hydrochloride
antiplatelet antibacterial antiinflammatory
1992 2009 1994
28 (326) 45 (482) 30 (297)
antihypertensive
1983
19 (315)
antiallergy anticancer antihypertensive
2000 2004 1987
36 (297) 40 (450) 23 (328)
anticancer antibacterial anticancer nootropic
2000 2002 1995 1987
36 (298) 38 (351) 31 (338) 23 (329)
antiallergy antiglaucoma sleep disorders antihypercholesterolemic coronary artery disease, antirestenotic anticancer
2010 2001 1983 1986 2008
46 (449) 37 (261) 19 (315) 22 (317) 44 (586)
1990
26 (300)
antihypertensive antithrombotic antipsychotic antiviral antihypertensive anticancer antihypertensive anticancer anticancer antiglaucoma antiglaucoma antibacterial antiinflammatory sleep disorders cerebral vasodilator immunomodulator congestive heart failure Parkinson’s disease antihypertensive antimalarial antihypertensive
1986 2000 2008 2011 1985 2003 2001 2012 2011 1996 1998 1993 1997 1983 1986 1987 1984 1997 1983 2000 1985
22 (317) 36 (298) 44 (587) 47 (521) 21 (324) 39 (271) 37 (262) 48 (489) 47 (523) 32 (306) 34 (318) 29 (333) 33 (329) 19 (315) 22 (317) 23 (329) 20 (316) 33 (330) 19 (315) 36 (299) 21 (324)
583
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
bupropion hydrochloride buserelin acetate buspirone hydrochloride butenafine hydrochloride butibufen butoconazole butoctamide butyl flufenamate cabazitaxel cabergoline cabozantinib cadexomer iodine cadralazine calcipotriol camostat mesylate canakinumab candesartan cilexetil capecitabine captopril carboplatin carfilzomib carperitide carumonam carvedilol caspofungin acetate catumaxomab cefbuperazone sodium cefcapene pivoxil cefdinir cefditoren pivoxil cefepime cefetamet pivoxil hydrochloride cefixime cefmenoxime hydrochloride cefminox sodium cefodizime sodium cefonicid sodium ceforanide cefoselis cefotetan disodium
antidepressant
1989
25 (310)
hormone therapy anxiolytic
1984 1985
20 (316) 21 (324)
antifungal
1992
28 (327)
antiinflammatory antifungal sleep disorders antiinflammatory anticancer antiprolactin anticancer wound healing agent antihypertensive antipsoriasis anticancer antiinflammatory antihypertensive anticancer antihypertensive antibacterial anticancer congestive heart failure antibacterial antihypertensive antifungal anticancer antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial
1992 1986 1984 1983 2010 1993 2012 1983 1988 1991 1985 2009 1997 1998 1982 1986 2012 1995 1988 1991 2001 2009 1985 1997 1991 1994 1993 1992
28 22 20 19 46 29 48 19 24 27 21 45 33 34 13 22 48 31 24 27 37 45 21 33 27 30 29 28
antibacterial antibacterial
1987 1983
23 (329) 19 (316)
antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial
1987 1990 1984 1984 1998 1984
23 26 20 20 34 20
(327) (318) (316) (316) (451) (334) (491) (316) (298) (323) (325) (484) (330) (319) (086) (318) (492) (339) (298) (323) (263) (486) (325) (330) (323) (297) (334) (327)
(330) (300) (316) (317) (319) (317)
584
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
cefotiam hexetil hydrochloride cefozopran hydrochloride cefpimizole cefpiramide sodium cefpirome sulfate cefpodoxime proxetil cefprozil ceftaroline fosamil ceftazidime cefteram pivoxil ceftibuten ceftobiprole medocaril cefuroxime axetil cefuzonam sodium celecoxib celiprolol hydrochloride centchroman centoxin cerivastatin certolizumab pegol cetirizine hydrochloride cetrorelix cetuximab cevimeline hydrochloride chenodiol CHF-1301 choline alfoscerate choline fenofibrate cibenzoline ciclesonide cicletanine cidofovir cilazapril cilostazol cimetropium bromide cinacalcet cinildipine cinitapride cinolazepam ciprofibrate
antibacterial
1991
27 (324)
antibacterial
1995
31 (339)
antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antiarthritic antihypertensive
1987 1985 1992 1989 1992 2010 1983 1987 1992 2008 1987 1987 1999 1983
23 (330) 21 (325) 28 (328) 25 (310) 28 (328) 46 (453) 19 (316) 23 (330) 28 (329) 44 (589) 23 (331) 23 (331) 35 (335) 19 (317)
contraception immunomodulator antihypercholesterolemic irritable bowel syndrome antiallergy
1991 1991 1997 2008 1987
27 (324) 27 (325) 33 (331) 44 (592) 23 (331)
infertility anticancer antixerostomia
1999 2003 2000
35 (336) 39 (272) 36 (299)
gallstones Parkinson’s disease cognition enhancer antihypercholesterolemic antiarrhythmic antiasthma antihypertensive antiviral antihypertensive antithrombotic antispasmodic hyperparathyroidism antihypertensive gastroprokinetic anxiolytic antihypercholesterolemic
1983 1999 1990 2008 1985 2005 1988 1996 1990 1988 1985 2004 1995 1990 1993 1985
19 (317) 35 (336) 26 (300) 44 (594) 21 (325) 41 (443) 24 (299) 32 (306) 26 (301) 24 (299) 21 (326) 40 (451) 31 (339) 26 (301) 29 (334) 21 (326)
585
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
ciprofloxacin cisapride cisatracurium besilate citalopram cladribine clarithromycin clevidipine clevudine clobenoside cloconazole hydrochloride clodronate disodium clofarabine clopidogrel hydrogensulfate cloricromen clospipramine hydrochloride colesevelam hydrochloride colestimide colforsin daropate hydrochloride conivaptan corifollitropin alfa crizotinib crofelemer crotelidae polyvalent immune fab cyclosporine cytarabine ocfosfate dabigatran etexilate dalfampridine dalfopristin dapagliflozin dapiprazole hydrochloride dapoxetine daptomycin darifenacin
antibacterial gastroprokinetic muscle relaxant antidepressant anticancer antibacterial antihypertensive antiviral antiinflammatory antifungal
1986 1988 1995 1989 1993 1990 2008 2007 1988 1986
22 24 31 25 29 26 44 43 24 22
calcium regulation anticancer antithrombotic
1986 2005 1998
22 (319) 41 (444) 34 (320)
antithrombotic antipsychotic
1991 1991
27 (325) 27 (325)
antihypercholesterolemic
2000
36 (300)
antihypercholesterolemic congestive heart failure
1999 1999
35 (337) 35 (337)
hyponatremia infertility anticancer antidiarrheal antidote, snake venom poisoning immunosuppressant anticancer anticoagulant multiple sclerosis antibacterial antidiabetic antiglaucoma
2006 2010 2011 2012 2001
42 46 47 48 37
(514) (455) (525) (494) (263)
1983 1993 2008 2010 1999 2012 1987
19 29 44 46 35 48 23
(317) (335) (598) (458) (338) (495) (332)
premature ejaculation antibacterial urinary tract/bladder disorders antiviral anticancer myelodysplastic syndromes iron chelation therapy
2009 2003 2005
45 (488) 39 (272) 41 (445)
2006 2006 2006 1995
42 42 42 31
darunavir dasatinib decitabine defeiprone
(318) (299) (340) (311) (335) (302) (596) (466) (300) (318)
(515) (517) (519) (340)
586
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
deferasirox defibrotide deflazacort degarelix acetate delapril delavirdine mesylate denileukin diftitox denopamine denosumab deprodone propionate desflurane desloratadine desvenlafaxine dexfenfluramine dexibuprofen dexlansoprazole dexmedetomidine hydrochloride dexmethylphenidate hydrochloride dexrazoxane dezocine diacerein didanosine dilevalol diquafosol tetrasodium dirithromycin disodium pamidronate divistyramine docarpamine docetaxel dofetilide dolasetron mesylate donepezil hydrochloride dopexamine doripenem dornase alfa dorzolamide hydrochloride dosmalfate doxacurium chloride doxazosin mesylate doxefazepam doxercalciferol
iron chelation therapy antithrombotic antiinflammatory anticancer antihypertensive antiviral anticancer congestive heart failure osteoporosis antiinflammatory anesthetic antiallergy antidepressant antiobesity antiinflammatory antiulcer sleep disorders
2005 1986 1986 2009 1989 1997 1999 1988 2010 1992 1992 2001 2008 1997 1994 2009 2000
41 (446) 22 (319) 22 (319) 45 (490) 25 (311) 33 (331) 35 (338) 24 (300) 46 (459) 28 (329) 28 (329) 37 (264) 44 (600) 33 (332) 30 (298) 45 (492) 36 (301)
attention deficit hyperactivity disorder cardioprotective analgesic antiinflammatory antiviral antihypertensive ophthalmologic (dry eye) antibacterial osteoporosis antihypercholesterolemic congestive heart failure anticancer antiarrhythmic antiemetic Alzheimer’s disease
2002
38 (352)
1992 1991 1985 1991 1989 2010 1993 1989 1984 1994 1995 2000 1998 1997
28 (330) 27 (326) 21 (326) 27 (326) 25 (311) 46 (462) 29 (336) 25 (312) 20 (317) 30 (298) 31 (341) 36 (301) 34 (321) 33 (332)
congestive heart failure antibacterial cystic fibrosis antiglaucoma
1989 2005 1994 1995
25 (312) 41 (448) 30 (298) 31 (341)
antiulcer muscle relaxant antihypertensive anxiolytic hyperparathyroidism
2000 1991 1988 1985 1999
36 (302) 27 (326) 24 (300) 21 (326) 35 (339)
587
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
doxifluridine doxofylline dronabinol dronedarone drospirenone drotrecogin alfa droxicam droxidopa duloxetine dutasteride duteplase ebastine eberconazole ebrotidine ecabet sodium ecallantide eculizumab edaravone edoxaban efalizumab efavirenz efonidipine egualen sodium eldecalcitol eletriptan eltrombopag emedastine difumarate emorfazone emtricitabine enalapril maleate enalaprilat encainide hydrochloride enfuvirtide enocitabine enoxacin enoxaparin enoximone enprostil entacapone entecavir enzalutamide epalrestat eperisone hydrochloride
anticancer antiasthma antiemetic antiarrhythmic contraception antisepsis antiinflammatory Parkinson’s disease antidepressant benign prostatic hyperplasia anticoagulant antiallergy antifungal antiulcer antiulcer angioedema, hereditary hemoglobinuria neuroprotective antithrombotic antipsoriasis antiviral antihypertensive antiulcer osteoporosis antimigraine antithrombocytopenic antiallergy analgesic antiviral antihypertensive antihypertensive antiarrhythmic
1987 1985 1986 2009 2000 2001 1990 1989 2004 2002 1995 1990 2005 1997 1993 2009 2007 2001 2011 2003 1998 1994 2000 2011 2001 2009 1993 1984 2003 1984 1987 1987
23 21 22 45 36 37 26 25 40 38 31 26 41 33 29 46 43 37 47 39 34 30 36 47 37 45 29 20 39 20 23 23
(332) (327) (319) (495) (302) (265) (302) (312) (452) (353) (342) (302) (449) (333) (336) (464) (468) (265) (527) (274) (321) (299) (303) (529) (266) (497) (336) (317) (274) (317) (332) (333)
antiviral anticancer antibacterial anticoagulant congestive heart failure antiulcer Parkinson’s disease antiviral anticancer antidiabetic muscle relaxant
2003 1983 1986 1987 1988 1985 1998 2005 2012 1992 1983
39 19 22 23 24 21 34 41 48 28 19
(275) (318) (320) (333) (301) (327) (322) (450) (497) (330) (318)
588
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
epidermal growth factor epinastine epirubicin hydrochloride eplerenone epoprostenol sodium eprosartan eptazocine hydrobromide eptilfibatide erdosteine eribulin mesylate erlotinib ertapenem sodium erythromycin acistrate erythropoietin escitalopram oxolate eslicarbazepine acetate esmolol hydrochloride esomeprazole magnesium eszopiclone ethyl icosapentate etizolam etodolac etoricoxibe etravirine everolimus exemestane exenatide exifone ezetimibe factor VIIa factor VIII fadrozole hydrochloride falecalcitriol famciclovir famotidine fasudil hydrochloride febuxostat felbamate felbinac felodipine fenbuprol fenoldopam mesylate
wound healing agent antiallergy anticancer
1987 1994 1984
23 (333) 30 (299) 20 (318)
antihypertensive antiplatelet antihypertensive analgesic
2003 1983 1997 1987
39 (276) 19 (318) 33 (333) 23 (334)
antithrombotic expectorant anticancer anticancer antibacterial antibacterial hematopoietic antidepressant anticonvulsant antiarrhythmic antiulcer
1999 1995 2010 2004 2002 1988 1988 2002 2009 1987 2000
35 (340) 31 (342) 46 (465) 40 (454) 38 (353) 24 (301) 24 (301) 38 (354) 45 (498) 23 (334) 36 (303)
sleep disorders antithrombotic anxiolytic antiinflammatory antiarthritic antiviral immunosuppressant anticancer antidiabetic cognition enhancer antihypercholesterolemic haemophilia hemostatic anticancer hyperparathyroidism antiviral antiulcer amyotrophic lateral sclerosis gout anticonvulsant antiinflammatory antihypertensive biliary tract dysfunction antihypertensive
2005 1990 1984 1985 2002 2008 2004 2000 2005 1988 2002 1996 1992 1995 2001 1994 1985 1995 2009 1993 1986 1988 1983 1998
41 (451) 26 (303) 20 (318) 21 (327) 38 (355) 44 (602) 40 (455) 36 (304) 41 (452) 24 (302) 38 (355) 32 (307) 28 (330) 31 (342) 37 (266) 30 (300) 21 (327) 31 (343) 45 (501) 29 (337) 22 (320) 24 (302) 19 (318) 34 (322)
589
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
fenticonazole nitrate fesoterodine
antifungal urinary tract/bladder disorders antiallergy antibacterial immunostimulant benign prostatic hyperplasia multiple sclerosis antiinflammatory antibacterial antibacterial congestive heart failure antifungal anticancer antidote, benzodiazepine overdose antiinflammatory antidepressant
1987 2008
23 (334) 44 (604)
1996 2011 1991 1992 2010 1984 1992 1988 1992 1988 1991 1987
32 47 27 28 46 20 28 24 28 24 27 23
1987 1986
23 (335) 22 (320)
analgesic antibacterial
1985 1997
21 (328) 33 (333)
anticancer anxiolytic antiallergy antiinflammatory anxiolytic antifungal antiasthma antihypercholesterolemic antidepressant infertility infertility antidote, ethylene glycol poisoning antiviral antithrombotic anticancer chronic obstructive pulmonary disorder antiviral antiemetic
1983 1984 2007 1990 1986 1995 1988 1994 1983 1996 1996 1998
19 20 43 26 22 31 24 30 19 32 32 34
(318) (318) (469) (303) (320) (343) (303) (300) (319) (307) (308) (323)
1998 2002 1993 1986
34 38 29 22
(323) (356) (337) (321)
2003 2008
39 (277) 44 (606)
antiviral antifungal
1989 2004
25 (313) 40 (457)
fexofenadine fidaxomicin filgrastim finasteride fingolimod fisalamine fleroxacin flomoxef sodium flosequinan fluconazole fludarabine phosphate flumazenil flunoxaprofen fluoxetine hydrochloride flupirtine maleate flurithromycin ethylsuccinate flutamide flutazolam fluticasone furoate fluticasone propionate flutoprazepam flutrimazole flutropium bromide fluvastatin fluvoxamine maleate follitropin alfa follitropin beta fomepizole fomivirsen sodium fondaparinux sodium formestane formoterol fumarate fosamprenavir fosaprepitant dimeglumine foscarnet sodium fosfluconazole
(307) (531) (327) (331) (468) (318) (331) (302) (331) (303) (327) (335)
590
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
fosfosal fosinopril sodium fosphenytoin sodium fotemustine fropenam frovatriptan fudosteine fulveristrant gabapentin gabapentin Enacarbil gadoversetamide gallium nitrate gallopamil hydrochloride galsulfase ganciclovir ganirelix acetate garenoxacin gatilfloxacin gefitinib gemcitabine hydrochloride gemeprost gemifloxacin gemtuzumab ozogamicin gestodene gestrinone glatiramer acetate glimepiride glucagon, rDNA GMDP golimumab goserelin granisetron hydrochloride guanadrel sulfate gusperimus halobetasol propionate halofantrine halometasone histrelin hydrocortisone aceponate hydrocortisone butyrate
analgesic antihypertensive anticonvulsant anticancer antibacterial antimigraine expectorant anticancer anticonvulsant restless leg syndrome diagnostic calcium regulation antianginal
1984 1991 1996 1989 1997 2002 2001 2002 1993 2011 2000 1991 1983
20 (319) 27 (328) 32 (308) 25 (313) 33 (334) 38 (357) 37 (267) 38 (357) 29 (338) 47 (533) 36 (304) 27 (328) 19 (3190)
mucopolysaccharidosis VI antiviral infertility antibacterial antibacterial anticancer anticancer
2005 1988 2000 2007 1999 2002 1995
41 (453) 24 (303) 36 (305) 43 (471) 35 (340) 38 (358) 31 (344)
abortifacient antibacterial anticancer
1983 2004 2000
19 (319) 40 (458) 36 (306)
contraception contraception multiple sclerosis antidiabetic antidiabetic immunostimulant antiinflammatory hormone therapy antiemetic
1987 1986 1997 1995 1993 1996 2009 1987 1991
23 (335) 22 (321) 33 (334) 31 (344) 29 (338) 32 (308) 45 (503) 23 (336) 27 (329)
antihypertensive immunosuppressant antiinflammatory antimalarial antiinflammatory precocious puberty antiinflammatory
1983 1994 1991 1988 1983 1993 1988
19 (319) 30 (300) 27 (329) 24 (304) 19 (320) 29 (338) 24 (304)
antiinflammatory
1983
19 (320)
591
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
ibandronic acid ibopamine hydrochloride ibritunomab tiuxetan ibudilast ibutilide fumarate icatibant idarubicin hydrochloride idebenone idursulfase
osteoporosis congestive heart failure
1996 1984
32 (309) 20 (319)
anticancer antiasthma antiarrhythmic angioedema, hereditary anticancer
2002 1989 1996 2008 1990
38 25 32 44 26
nootropic mucopolysaccharidosis II (Hunter syndrome) antiarthritic antiplatelet anticancer urinary tract/bladder disorders antihypertensive Gaucher’s disease antibacterial antiviral osteoporosis chronic obstructive pulmonary disease antidepressant nootropic
1986 2006
22 (321) 42 (520)
2011 1992 2001 2007
47 28 37 43
(535) (332) (267) (472)
1993 1994 1985 1997 1997 2009
29 30 21 33 33 45
(339) (301) (328) (335) (335) (505)
1983 1988
19 (320) 24 (304)
antiviral antiemetic antithrombotic antiviral anticancer antidiabetic antiviral immunostimulant multiple sclerosis multiple sclerosis antiinflammatory anticancer anticancer diagnostic anticancer osteoporosis antihypertensive anticancer
1996 2004 1984 2003 2012 1996 1997 1991 1996 1993 1989 1992 1989 2000 2011 1989 1997 1994
32 40 20 39 48 32 33 27 32 29 25 28 25 36 47 25 33 30
iguratimod iloprost imatinib mesylate imidafenacin imidapril hydrochloride imiglucerase imipenem/cilastatin imiquimod incadronic acid indacaterol indalpine indeloxazine hydrochloride indinavir sulfate indisetron indobufen influenza virus (live) ingenol mebutate insulin lispro interferon alfacon-1 interferon gamma-1b interferon, b-1a interferon, b-1b interferon, gamma interferon, gamma-1 interleukin-2 ioflupane ipilimumab ipriflavone irbesartan irinotecan
(359) (313) (309) (608) (303)
(310) (459) (319) (277) (499) (310) (336) (329) (311) (339) (314) (332) (314) (306) (537) (314) (336) (301)
592
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
irsogladine isepamicin isofezolac isoxicam isradipine itopride hydrochloride itraconazole ivabradine ivacaftor ivermectin ixabepilone ketanserin ketorolac tromethamine kinetin
antiulcer antibacterial antiinflammatory antiinflammatory antihypertensive gastroprokinetic antifungal antianginal cystic fibrosis antiparasitic anticancer antihypertensive analgesic
1989 1988 1984 1983 1989 1995 1988 2006 2012 1987 2007 1985 1990
25 (315) 24 (305) 20 (319) 19 (320) 25 (315) 31 (344) 24 (305) 42 (522) 48 (501) 23 (336) 43 (473) 21 (328) 26 (304)
dermatologic, skin photodamage antihypertensive anticonvulsant antiulcer antiviral anticonvulsant antiarrhythmic antiviral antifungal growth disorders antiulcer anticancer mucopolysaccharidosis I antiglaucoma antiarthritic myelodysplastic syndromes, multiple myeloma antibacterial
1999
35 (341)
1991 2008 2000 1995 1990 2002 2010 1994 1995 1992 2007 2003 1996 1998 2006
27 (330) 44 (610) 36 (307) 31 (345) 26 (304) 38 (360) 46 (470) 30 (302) 31 (345) 28 (332) 43 (475) 39 (278) 32 (311) 34 (324) 42 (523)
1987
23 (336)
immunostimulant anticoagulant antihypertensive anticancer hormone therapy cognition enhancer
1986 1997 1997 1996 1984 1986
22 (322) 33 (336) 33 (337) 32 (311) 20 (319) 22 (322)
antiasthma
1999
35 (341)
anticonvulsant antiglaucoma
2000 1985
36 (307) 21 (328)
lacidipine lacosamide lafutidine lamivudine lamotrigine landiolol laninamivir octanoate lanoconazole lanreotide acetate lansoprazole lapatinib laronidase latanoprost lefunomide lenalidomide lenampicillin hydrochloride lentinan lepirudin lercanidipine letrazole leuprolide acetate levacecarnine hydrochloride levalbuterol hydrochloride levetiracetam levobunolol hydrochloride
593
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
levobupivacaine hydrochloride levocabastine hydrochloride levocetirizine levodropropizine levofloxacin levosimendan lidamidine hydrochloride limaprost linaclotide linagliptin linezolid liraglutide liranaftate lisdexamfetamine
anesthetic
2000
36 (308)
antiallergy
1991
27 (330)
antiallergy antitussive antibacterial congestive heart failure antidiarrheal
2001 1988 1993 2000 1984
37 24 29 36 20
(268) (305) (340) (308) (320)
antithrombotic irritable bowel syndrome antidiabetic antibacterial antidiabetic antifungal attention deficit hyperactivity disorder antihypertensive antiinflammatory antiallergy
1988 2012 2011 2000 2009 2000 2007
24 48 47 36 45 36 43
(306) (502) (540) (309) (507) (309) (477)
1987 1986 1992
23 (337) 22 (322) 28 (333)
antibacterial antimigraine
1989 1999
25 (315) 35 (342)
antihypercholersteremic anticancer antiviral sleep disorders congestive heart failure
2012 1987 2000 1983 1996
48 23 36 19 32
antibacterial antiallergy antiobesity
1992 1988 2012
28 (333) 24 (306) 48 (506)
antiinflammatory antihypertensive antiallergy antihypercholesterolemic antiinflammatory constipation antifungal antiinflammatory antipsychotic
1997 1994 1998 1987 1986 2006 2005 2005 2010
33 30 34 23 22 42 41 41 46
Lyme disease
1999
35 (342)
lisinopril lobenzarit sodium lodoxamide tromethamine lomefloxacin lomerizine hydrochloride lomitapide mesylate lonidamine lopinavir loprazolam mesylate loprinone hydrochloride loracarbef loratadine lorcaserin hydrochloride lornoxicam losartan loteprednol etabonate lovastatin loxoprofen sodium lulbiprostone luliconazole lumiracoxib lurasidone hydrochloride Lyme disease vaccine
(504) (337) (310) (321) (312)
(337) (302) (324) (337) (322) (525) (454) (455) (473)
594
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
mabuterol hydrochloride malotilate manidipine hydrochloride maraviroc masoprocol maxacalcitol mebefradil hydrochloride medifoxamine fumarate mefloquine hydrochloride meglutol melinamide meloxicam mepixanox meptazinol hydrochloride meropenem metaclazepam metapramine methylnaltrexone bromide mexazolam micafungin mifamurtide mifepristone miglitol miglustat milnacipran milrinone miltefosine minodronic acid miokamycin mirabegron
antiasthma
1986
22 (323)
hepatoprotective antihypertensive
1985 1990
21 (329) 26 (304)
antiviral anticancer hyperparathyroidism antihypertensive
2007 1992 2000 1997
43 (478) 28 (333) 36 (310) 33 (338)
antidepressant antimalarial
1986 1985
22 (323) 21 (329)
antihypercholesterolemic antihypercholesterolemic antiarthritic respiratory stimulant analgesic
1983 1984 1996 1984 1983
19 (321) 20 (320) 32 (312) 20 (320) 19 (321)
antibacterial anxiolytic antidepressant constipation
1994 1987 1984 2008
30 (303) 23 (338) 20 (320) 44 (612)
anxiolytic antifungal anticancer abortifacient antidiabetic Gaucher’s disease antidepressant congestive heart failure anticancer osteoporosis antibacterial urinary tract/bladder disorders antidepressant antiulcer antidiabetic anticancer
1984 2002 2009 1988 1998 2003 1997 1989 1993 2009 1985 2011
20 (321) 38 (360) 46 (476) 24 (306) 34 (325) 39 (279) 33 (338) 25 (316) 29 (340) 45 (509) 21 (329) 47 (542)
1994 1985 2004 1984
30 (303) 21 (329) 40 (460) 20 (321)
muscle relaxant hepatoprotective antiallergy
1992 1999 1998
28 (334) 35 (343) 34 (325)
mirtazapine misoprostol mitiglinide mitoxantrone hydrochloride mivacurium chloride mivotilate mizolastine
595
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
mizoribine moclobemide modafinil moexipril hydrochloride mofezolac mogamulizumab mometasone furoate montelukast sodium moricizine hydrochloride mosapride citrate moxifloxacin hydrochloride moxonidine mozavaptan mupirocin muromonab-CD3 muzolimine mycophenolate mofetil mycophenolate sodium nabumetone nadifloxacin nafamostat mesylate nafarelin acetate naftifine hydrochloride naftopidil
immunosuppressant antidepressant sleep disorders antihypertensive
1984 1990 1994 1995
20 26 30 31
(321) (305) (303) (346)
analgesic anticancer antiinflammatory antiasthma antiarrhythmic
1994 2012 1987 1998 1990
30 48 23 34 26
(304) (507) (338) (326) (305)
gastroprokinetic antibacterial
1998 1999
34 (326) 35 (343)
antihypertensive hyponatremia antibacterial immunosuppressant diuretic immunosuppressant immunosuppressant antiinflammatory antibacterial pancreatitis hormone therapy antifungal urinary tract/bladder disorders pruritus
1991 2006 1985 1986 1983 1995 2003 1985 1993 1986 1990 1984 1999
27 42 21 22 19 31 39 21 29 22 26 20 35
2009
45 (510)
addiction, opioids
1995
31 (347)
addiction, opioids
1984
20 (322)
antimigraine
1997
33 (339)
leukopenia multiple sclerosis antidiabetic antiemetic antihypertensive anticancer antiallergy antidepressant anticancer
1994 2004 1999 1994 1997 1995 1986 1994 2006
30 40 35 30 33 31 22 30 42
nalfurafine hydrochloride nalmefene hydrochloride naltrexone hydrochloride naratriptan hydrochloride nartograstim natalizumab nateglinide nazasetron nebivolol nedaplatin nedocromil sodium nefazodone nelarabine
(330) (527) (330) (323) (321) (346) (279) (330) (340) (323) (306) (321) (344)
(304) (462) (344) (305) (339) (347) (324) (305) (528)
596
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
nelfinavir mesylate neltenexine nemonapride nepafenac neridronic acide nesiritide neticonazole hydrochloride nevirapine nicorandil nif ekalant hydrochloride nilotinib nilutamide nilvadipine nimesulide nimodipine nimotuzumab nipradilol nisoldipine nitisinone nitrefazole nitrendipine nizatidine nizofenzone nomegestrol acetate norelgestromin norfloxacin norgestimate OCT-43 octreotide ofatumumab ofloxacin olanzapine olimesartan Medoxomil olopatadine hydrochloride omacetaxine mepesuccinate omalizumab allergic omeprazole ondansetron hydrochloride OP-1 orlistat
antiviral cystic fibrosis antipsychotic antiinflammatory calcium regulation congestive heart failure antifungal
1997 1993 1991 2005 2002 2001 1993
33 (340) 29 (341) 27 (331) 41 (456) 38 (361) 37 (269) 29 (341)
antiviral antianginal antiarrhythmic
1996 1984 1999
32 (313) 20 (322) 35 (344)
anticancer anticancer antihypertensive antiinflammatory cerebral vasodilator anticancer antihypertensive antihypertensive antityrosinaemia addiction, alcohol antihypertensive antiulcer nootropic contraception contraception antibacterial contraception anticancer growth disorders anticancer antibacterial antipsychotic antihypertensive antiallergy
2007 1987 1989 1985 1985 2006 1988 1990 2002 1983 1985 1987 1988 1986 2002 1983 1986 1999 1988 2009 1985 1996 2002 1997
43 (480) 23 (338) 25 (316) 21 (330) 21 (330) 42 (529) 24 (307) 26 (306) 38 (361) 19 (322) 21 (331) 23 (339) 24 (307) 22 (324) 38 (362) 19 (322) 22 (324) 35 (345) 24 (307) 45 (512) 21 (331) 32 (313) 38 (363) 33 (340)
anticancer
2012
48 (510)
antiasthma antiulcer antiemetic
2003 1988 1990
39 (280) 24 (308) 26 (306)
osteoinductor antiobesity
2001 1998
37 (269) 34 (327)
597
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
ornoprostil osalazine sodium oseltamivir phosphate oxaliplatin oxaprozin oxcarbazepine oxiconazole nitrate oxiracetam oxitropium bromide ozagrel sodium paclitaxal palifermin paliperidone palonosetron panipenem/ betamipron carbapenem panitumumab pantoprazole sodium parecoxib sodium paricalcitol parnaparin sodium paroxetine pasireotide pazopanib pazufloxacin pefloxacin mesylate pegademase bovine pegaptanib
antiulcer antiinflammatory antiviral anticancer antiinflammatory anticonvulsant antifungal cognition enhancer antiasthma antithrombotic anticancer mucositis antipsychotic antiemetic antibacterial
1987 1986 1999 1996 1983 1990 1983 1987 1983 1988 1993 2005 2007 2003 1994
23 22 35 32 19 26 19 23 19 24 29 41 43 39 30
(339) (324) (346) (313) (322) (307) (322) (339) (323) (308) (342) (461) (482) (281) (305)
anticancer antiulcer analgesic hyperparathyroidism anticoagulant antidepressant Cushing’s Disease anticancer antibacterial antibacterial immunostimulant ophthalmologic (macular degeneration) anticancer hematopoietic growth disorders anticancer antiasthma antiviral anticancer antiviral anticonvulsant Parkinson’s disease antihypertensive antipsychotic
2006 1995 2002 1998 1993 1991 2012 2009 2002 1985 1990 2005
42 30 38 34 29 27 48 45 38 21 26 41
(531) (306) (364) (327) (342) (331) (512) (514) (364) (331) (307) (458)
1994 2012 2003 2004 1991 1996 1992 2010 2012 1988 1988 2001
30 48 39 40 27 32 28 46 48 24 24 37
(306) (514) (281) (463) (331) (314) (334) (477) (516) (308) (309) (270)
anticancer antithrombotic
2012 1987
48 (517) 23 (340)
pegaspargase peginesatide pegvisomant pemetrexed pemirolast potassium penciclovir pentostatin peramivir perampanel pergolide mesylate perindopril perospirone hydrochloride pertuzumab picotamide
598
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
pidotimod piketoprofen pilsicainide hydrochloride pimaprofen pimecrolimus pimobendan pinacidil pioglitazone hydrochloride pirarubicin pirfenidone pirmenol piroxicam cinnamate pitavastatin pivagabine pixantrone dimaleate plaunotol plerixafor hydrochloride polaprezinc ponatinib porfimer sodium posaconazole pralatrexate pramipexole hydrochloride pramiracetam sulfate pramlintide pranlukast prasugrel pravastatin prednicarbate pregabalin prezatide copper acetate progabide promegestrone propacetamol hydrochloride propagermanium propentofylline propionate propiverine hydrochloride propofol
immunostimulant antiinflammatory antiarrhythmic
1993 1984 1991
29 (343) 20 (322) 27 (332)
antiinflammatory immunosuppressant congestive heart failure antihypertensive antidiabetic
1984 2002 1994 1987 1999
20 (322) 38 (365) 30 (307) 23 (340) 35 (346)
anticancer pulmonary fibrosis, idiopathic antiarrhythmic antiinflammatory antihypercholesterolemic antidepressant anticancer antiulcer stem cell mobilizer
1988 2008 1994 1988 2003 1997 2012 1987 2009
24 (309) 44 (614) 30 (307) 24 (309) 39 (282) 33 (341) 48 (519) 23 (340) 45 (515)
antiulcer anticancer anticancer antifungal anticancer Parkinson’s disease
1994 2012 1993 2006 2009 1997
30 (307) 48 (521) 29 (343) 42 (532) 45 (517) 33 (341)
cognition enhancer antidiabetic antiasthma antiplatelet antihypercholesterolemic antiinflammatory anticonvulsant wound healing agent anticonvulsant contraception analgesic
1993 2005 1995 2009 1989 1986 2004 1996 1985 1983 1986
29 (343) 41 (460) 31 (347) 45 (519) 25 (316) 22 (325) 40 (464) 32 (314) 21 (331) 19 (323) 22 (325)
antiviral cerebral vasodilator
1994 1988
30 (308) 24 (310)
urinary tract/bladder disorders anesthetic
1992
28 (335)
1986
22 (325)
599
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
prulifloxacin pumactant quazepam quetiapine fumarate quinagolide quinapril quinf amideamebicide quinupristin rabeprazole sodium radotinib raloxifene hydrochloride raltegravir raltitrexed ramatroban ramelteon ramipril ramosetron ranibizumab
antibacterial respiratory distress syndrome sleep disorders antipsychotic hyperprolactinemia antihypertensive antiparasitic antibacterial antiulcer anticancer osteoporosis
2002 1994 1985 1997 1994 1989 1984 1999 1998 2012 1998
38 30 21 33 30 25 20 35 34 48 34
(366) (308) (332) (341) (309) (317) (322) (338) (328) (523) (328)
antiviral anticancer antiallergy sleep disorders antihypertensive antiemetic ophthalmologic (macular degeneration) anticancer antiulcer
2007 1996 2000 2005 1989 1996 2006
43 32 36 41 25 32 42
(484) (315) (311) (462) (317) (315) (534)
1987 1995
23 (341) 31 (348)
antianginal muscle relaxant Parkinson’s disease antiulcer antidepressant anticancer analgesic
2006 1999 2005 1990 1997 2012 1996
42 35 41 26 33 48 32
antipsychotic
1990
26 (308)
antidiabetic antiallergy antibacterial antithrombotic anticonvulsant anticoagulant antibacterial antibacterial antibacterial antibacterial sleep disorders antihypertensive
1998 1987 2007 1996 2011 1993 1992 1988 1985 1987 1989 1988
34 23 43 32 47 29 28 24 21 23 25 24
ranimustine ranitidine bismuth citrate ranolazine rapacuronium bromide rasagiline rebamipide reboxetine regorafenib remifentanil hydrochloride remoxipride hydrochloride repaglinide repirinast retapamulin reteplase retigabine reviparin sodium rifabutin rifapentine rifaximin rifaximin rilmazafone rilmenidine
(535) (347) (464) (308) (342) (524) (316)
(329) (341) (486) (316) (544) (344) (335) (310) (332) (341) (317) (310)
600
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
rilonacept
genetic autoinflammatory syndromes antiviral amyotrophic lateral sclerosis antiviral
2008
44 (615)
2011 1996 1987
47 (546) 32 (316) 23 (342)
antiinflammatory antiobesity osteoporosis antipsychotic antiviral anticoagulant Alzheimer’s disease antimigraine muscle relaxant antiarthritic chronic obstructive pulmonary disorder antibacterial anticancer antithrombocytopenic immunostimulant antihypercholesterolemic Parkinson’s disease
1995 2006 1998 1993 1996 2008 1997 1998 1994 1999 2010
31 (348) 42 (537) 34 (330) 29 (344) 32 (317) 44 (617) 33 (342) 34 (330) 30 (309) 35 (347) 46 (480)
1986 2009 2008 1991 1986 1996
22 (325) 46 (482) 44 (619) 27 (332) 22 (326) 32 (317)
anesthetic antiulcer antidiabetic antihypercholesterolemic Parkinson’s disease antiulcer
1996 1985 1999 2003 2006 1986
32 (318) 21 (332) 35 (348) 39 (283) 42 (538) 22 (326)
antiulcer anticonvulsant antibacterial
1987 2007 1992
23 (342) 43 (488) 28 (335)
antiallergy anticancer antibacterial antiasthma
2003 2011 1989 1990
39 (284) 47 (548) 25 (318) 26 (308)
phenylketouria
1992
28 (336)
antiviral immunostimulant
1995 1991
31 (349) 27 (332)
rilpivirine riluzole rimantadine hydrochloride rimexolone rimonabant risedronate sodium risperidone ritonavir rivaroxaban rivastigmin rizatriptan benzoate rocuronium bromide rofecoxib roflumilast rokitamycin romidepsin romiplostim romurtide ronafibrate ropinirole hydrochloride ropivacaine rosaprostol rosiglitazone maleate rosuvastatin rotigotine roxatidine acetate hydrochloride roxithromycin rufinamide rufloxacin hydrochloride rupatadine fumarate ruxolitinib RV-11 salmeterol hydroxynaphthoate sapropterin hydrochloride saquinavir mesvlate sargramostim
601
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
sarpogrelate hydrochloride saxagliptin schizophyllan seratrodast sertaconazole nitrate sertindole setastine hydrochloride setiptiline setraline hydrochloride sevoflurane sibutramine sildenafil citrate silodosin
antithrombotic
1993
29 (344)
antidiabetic immunostimulant antiasthma antifungal antipsychotic antiallergy antidepressant antidepressant anesthetic antiobesity male sexual dysfunction urinary tract/bladder disorders antihypercholesterolemic anticancer antibacterial antidiabetic pulmonary hypertension antiinflammatory anticancer anticancer urinary tract/bladder disorders antiulcer urinary tract/bladder disorders growth disorders growth disorders growth disorders anticancer antiviral antibacterial antihypertensive antiulcer antiviral osteoporosis antidote, lead poisoning analgesic neuromuscular blockade, reversal antibacterial antifungal antibacterial
2009 1985 1995 1992 1996 1987 1989 1990 1990 1998 1998 2006
45 22 31 28 32 23 25 26 26 34 34 42
(521) (326) (349) (336) (318) (342) (318) (309) (309) (331) (331) (540)
1988 2010 2008 2006 2006 2002 1999 1994 1983
24 46 44 42 42 38 35 30 19
(311) (484) (621) (541) (543) (366) (348) (310) (323)
1984 2004
20 (323) 40 (466)
1994 1994 1987 2005 1993 1993 1995 1987 1994 2004 1991 1983 2008
30 30 23 41 29 29 31 23 30 40 27 19 44
1986 1985 1987
22 (326) 21 (332) 23 (343)
simvastatin sipuleucel-t sitafloxacin hydrate sitagliptin sitaxsentan sivelestat SKI-2053R sobuzoxane sodium cellulose phosphate sofalcone solifenacin somatomedin-1 somatotropin somatropin sorafenib sorivudine sparfloxacin spirapril hydrochloride spizofurone stavudine strontium ranelate succimer sufentanil sugammadex sulbactam sodium sulconizole nitrate sultamycillin tosylate
(310) (310) (343) (466) (345) (345) (349) (343) (311) (466) (333) (323) (623)
602
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
sumatriptan succinate sunitinib suplatast tosilate suprofen surfactant TA tacalcitol tacrine hydrochloride tacrolimus tadalafil tafamidis tafluprost talaporfin sodium talipexole taltirelin tamibarotene tamsulosin hydrochloride tandospirone tapentadol hydrochloride tasonermin tazanolast tazarotene tazobactam sodium teduglutide tegaserod maleate teicoplanin telaprevir telavancin telbivudine telithromycin telmesteine telmisartan temafloxacin hydrochloride temocapril temocillin disodium temoporphin temozolomide temsirolimus teneligliptin tenofovir disoproxil fumarate tenoxicam teprenone
antimigraine anticancer antiallergy analgesic respiratory surfactant antipsoriasis Alzheimer’s disease immunosuppressant male sexual dysfunction neurodegeneration antiglaucoma anticancer Parkinson’s disease neurodegeneration anticancer benign prostatic hyperplasia
1991 2006 1995 1983 1987 1993 1993 1993 2003 2011 2008 2004 1996 2000 2005 1993
27 (333) 42 (544) 31 (350) 19 (324) 23 (344) 29 (346) 29 (346) 29 (347) 39 (284) 47 (550) 44 (625) 40 (469) 32 (318) 36 (311) 41 (467) 29 (347)
anxiolytic analgesic
1996 2009
32 (319) 45 (523)
anticancer antiallergy antipsoriasis antibacterial short bowel syndrome irritable bowel syndrome antibacterial antiviral antibacterial antiviral antibacterial expectorant antihypertensive antibacterial
1999 1990 1997 1992 2012 2001 1988 2011 2009 2006 2001 1992 1999 1991
35 (349) 26 (309) 33 (343) 28 (336) 48 (526) 37 (270) 24 (311) 47 (552) 45 (525) 42 (546) 37 (271) 28 (337) 35 (349) 27 (334)
antihypertensive antibacterial anticancer anticancer anticancer antidiabetic antiviral
1994 1984 2002 1999 2007 2012 2001
30 (311) 20 (323) 38 (367) 35 (349) 43 (490) 48 (528) 37 (271)
antiinflammatory antiulcer
1987 1984
23 (344) 20 (323)
603
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
terazosin hydrochloride terbinafine hydrochloride terconazole teriflunomide tertatolol hydrochloride tesamorelin acetate thrombin alfa thrombomodulin (recombinant) thymopentin tiagabine tiamenidine hydrochloride tianeptine sodium tibolone ticagrelor tigecycline tilisolol hydrochloride tiludronate disodium timiperone tinazoline tioconazole tiopronin tiotropium bromide
antihypertensive antifungal
1984 1991
20 (323) 27 (334)
antifungal multiple sclerosis antihypertensive lipodystrophy hemostatic anticoagulant
1983 2012 1987 2010 2008 2008
19 48 23 46 44 44
immunomodulator anticonvulsant antihypertensive
1985 1996 1988
21 (333) 32 (319) 24 (311)
antidepressant hormone therapy antithrombotic antibacterial antihypertensive Paget’s disease antipsychotic nasal decongestant antifungal urolithiasis chronic obstructive pulmonary disorder antiviral antispasmodic antiarrhythmic subarachnoid hemorrhage antithrombotic muscle relaxant
1983 1988 2010 2005 1992 1995 1984 1988 1983 1989 2002
19 24 46 41 28 31 20 24 19 25 38
(324) (312) (488) (468) (337) (350) (323) (312) (324) (318) (368)
2005 1984 1990 1995 1998 1983
41 20 26 31 34 19
(470) (324) (310) (351) (332) (324)
muscle relaxant antiarthritic Parkinson’s disease antidepressant antidiabetic hyponatremia anticonvulsant anticancer
1984 2012 1997 1984 1989 2009 1995 1996
20 48 33 20 25 45 31 32
(324) (532) (343) (324) (319) (528) (351) (320)
diuretic anticancer anticancer
1993 1989 2003
29 (348) 25 (319) 39 (285)
tipranavir tiquizium bromide tiracizine hydrochloride tirilazad mesylate tirofiban hydrochloride tiropramide hydrochloride tizanidine tofacitinib tolcapone toloxatone tolrestat tolvaptan topiramate topotecan hydrochloride torasemide toremifene tositumomab
(324) (530) (344) (486) (627) (628)
604
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
tosufloxacin tosylate trabectedin trandolapril travoprost treprostinil sodium tretinoin tocoferil trientine hydrochloride trimazosin hydrochloride trimegestone trimetrexate glucuronate troglitazone tropisetron trovafloxacin mesylate troxipide ubenimex udenafil ulipristal acetate unoprostone isopropyl ester ustekinumab vadecoxib vaglancirclovir hydrochloride valaciclovir hydrochloride valrubicin valsartan vandetanib vardenafil varenicline vemurafenib venlafaxine vernakalant verteporfin
antibacterial anticancer antihypertensive antiglaucoma antihypertensive antiulcer antidote, copper poisoning antihypertensive
1990 2007 1993 2001 2002 1993 1986 1985
26 (310) 43 (492) 29 (348) 37 (272) 38 (368) 29 (348) 22 (327) 21 (333)
contraception antifungal
2001 1994
37 (273) 30 (312)
antidiabetic antiemetic antibacterial antiulcer immunostimulant male sexual dysfunction contraception antiglaucoma
1997 1992 1998 1986 1987 2005 2009 1994
33 (344) 28 (337) 34 (332) 22 (327) 23 (345) 41 (472) 45 (530) 30 (312)
antipsoriasis antiarthritic antiviral
2009 2002 2001
45 (532) 38 (369) 37 (273)
antiviral
1995
31 (352)
anticancer antihypertensive anticancer male sexual dysfunction addiction, nicotine anticancer antidepressant antiarrhythmic ophthalmologic (macular degeneration) congestive heart failure anticonvulsant antidepressant antidiabetic anticancer anticancer anticancer antidiabetic
1999 1996 2011 2003 2006 2011 1994 2010 2000
35 (350) 32 (320) 47 (555) 39 (286) 42 (547) 47 (556) 30 (312) 46 (491) 36 (312)
1990 1989 2011 2007 2009 1989 2012 1994
26 (310) 25 (319) 47 (558) 43 (494) 46 (493) 25 (320) 48 (534) 30 (313)
vesnarinone vigabatrin vilazodone vildagliptin vinflunine vinorelbine vismodegib voglibose
605
Cumulative NCE Introduction Index, 1983–2012
GENERIC NAME
INDICATION
YEAR INTRODUCED
ARMC VOL., (PAGE)
voriconazole vorinostat xamoterol fumarate ximelagatran zafirlukast zalcitabine zaleplon zaltoprofen zanamivir ziconotide zidovudine zileuton zinostatin stimalamer ziprasidone hydrochloride zofenopril calcium zoledronate disodium zolpidem hemitartrate zomitriptan zonisamide zopiclone zucapsaicin zuclopenthixol acetate
antifungal anticancer congestive heart failure anticoagulant antiasthma antiviral sleep disorders antiinflammatory antiviral analgesic antiviral antiasthma anticancer antipsychotic
2002 2006 1988 2004 1996 1992 1999 1993 1999 2005 1987 1997 1994 2000
38 42 24 40 32 28 35 29 35 41 23 33 30 36
(370) (549) (312) (470) (321) (338) (351) (349) (352) (473) (345) (344) (313) (312)
antihypertensive osteoporosis sleep disorders antimigraine anticonvulsant sleep disorders analgesic antipsychotic
2000 2000 1988 1997 1989 1986 2010 1987
36 36 24 33 25 22 46 23
(313) (314) (313) (345) (320) (327) (495) (345)