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Cumulative NCE Introduction Index, 1983–2008
CUMULATIVE NCE INTRODUCTION INDEX, 1983–2008 GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
abacavir sulfate abarelix abatacept acarbose aceclofenac acemannan acetohydroxamic acid acetorphan acipimox acitretin acrivastine actarit adalimumab adamantanium bromide adefovir dipivoxil adrafinil AF-2259 afloqualone agalsidase alfa alacepril alclometasone dipropionate alefacept alemtuzumab alendronate sodium alfentanil HCl alfuzosin HCl alglucerase alglucosidase alfa aliskiren alitretinoin alminoprofen almotriptan anakinra anidulafungin alosetron hydrochloride alpha-1 antitrypsin alpidem alpiropride alteplase
antiviral anticancer rheumatoid arthritis antidiabetic antiinflammatory wound healing agent hypoammonuric antidiarrheal hypolipidemic antipsoriatic antihistamine antirheumatic rheumatoid arthritis antiseptic antiviral psychostimulant antiinflammatory muscle relaxant fabry’s disease antihypertensive topical antiinflammatory plaque psoriasis anticancer osteoporosis analgesic antihypertensive enzyme Pompe disease antihypertensive anticancer analgesic antimigraine antiarthritic antifungal irritable bowel syndrome protease inhibitor anxiolytic antimigraine thrombolytic
1999 2004 2006 1990 1992 2001 1983 1993 1985 1989 1988 1994 2003 1984 2002 1986 1987 1983 2001 1988 1985 2003 2001 1993 1983 1988 1991 2006 2007 1999 1983 2000 2001 2006 2000 1988 1991 1988 1987
35, 40, 42, 26, 28, 37, 19, 29, 21, 25, 24, 30, 39, 20, 38, 22, 23, 19, 37, 24, 21, 39, 37, 29, 19, 24, 27, 42, 43, 35, 19, 36, 37, 42, 36, 24, 27, 24, 23,
333 446 509 297 325 259 313 332 323 309 295 296 267 315 348 315 325 313 259 296 323 267 260 332 314 296 321 511 461 333 314 295 261 512 295 297 322 296 326
667
668
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
alvimopan ambrisentan
post-operative ileus pulmonary arterial hypertension antiinflammatory cytoprotective topical antiinflammatory antipsychotic antiasthmatic antihypertensive topical antifungal antihypertensive antiinflammatory antiviral cardiotonic antineoplastic antineoplastic antiinflammatory hematological antineoplastic anticancer adjuvant cognition enhancer antidote
2008 2007
44, 584 43, 463
1986 1995 1990 1986 1987 1990 1991 1988 1994 1999 1983 2002 1987 1993 1997 1995 1994 1993 2002
22, 31, 26, 22, 23, 26, 27, 24, 30, 35, 19, 38, 23, 29, 33, 31, 30, 29, 38,
315 338 298 316 327 298 322 297 296 334 314 349 327 332 328 338 296 333 350
1987 1988 2003 1987 1996 1990 2007
23, 24, 39, 23, 32, 26, 43,
326 297 268 326 306 298 465
1990 1999 2002 1986 2000 1987 1987 1983 1985 2003 2003
26, 35, 38, 22, 36, 23, 23, 19, 21, 39, 39,
299 335 350 316 296 327 328 314 324 269 270
1997 2000
33, 328 36, 297
amfenac sodium amifostine aminoprofen amisulpride amlexanox amlodipine besylate amorolfine HCl amosulalol ampiroxicam amprenavir amrinone amrubicin HCl amsacrine amtolmetin guacil anagrelide HCl anastrozole angiotensin II aniracetam anti-digoxin polyclonal antibody APD apraclonidine HCl aprepitant APSAC aranidipine arbekacin arformoterol argatroban arglabin aripiprazole arotinolol HCl arteether artemisinin aspoxicillin astemizole astromycin sulfate atazanavir atomoxetine atorvastatin calcium atosiban
calcium regulator antiglaucoma antiemetic thrombolytic antihypertensive antibiotic chronic obstructive pulmonary disease antithromobotic anticancer neuroleptic antihypertensive antimalarial antimalarial antibiotic antihistamine antibiotic antiviral attention deficit hyperactivity disorder dyslipidemia preterm labor
669
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
atovaquone auranofin azacitidine azelnidipine azelaic acid azelastine HCl azithromycin azosemide aztreonam balofloxacin balsalazide disodium bambuterol barnidipine HCl beclobrate befunolol HCl belotecan benazepril HCl benexate HCl benidipine HCl beraprost sodium betamethasone butyrate prospinate betaxolol HCl betotastine besilate bevacizumab bevantolol HCl bexarotene biapenem bicalutamide bifemelane HCl bimatoprost binfonazole binifibrate biolimus drug-eluting stent bisantrene HCl bisoprolol fumarate bivalirudin blonanserin bopindolol bortezomib bosentan brimonidine brinzolamide brodimoprin bromfenac sodium
antiparasitic chrysotherapeutic anticancer antihypertensive antiacne antihistamine antibiotic diuretic antibiotic antibacterial ulcerative colitis bronchodilator antihypertensive hypolipidemic antiglaucoma anticancer antihypertensive antiulcer antihypertensive platelet aggreg. inhibitor topical antiinflammatory
1992 1983 2004 2003 1989 1986 1988 1986 1984 2002 1997 1990 1992 1986 1983 2004 1990 1987 1991 1992 1994
28, 19, 40, 39, 25, 22, 24, 22, 20, 38, 33, 26, 28, 22, 19, 40, 26, 23, 27, 28, 30,
326 143 447 270 310 316 298 316 315 351 329 299 326 317 315 449 299 328 322 326 297
antihypertensive antiallergic anticancer antihypertensive anticancer antibacterial antineoplastic nootropic antiglaucoma hypnotic hypolipidemic anti-restenotic antineoplastic antihypertensive antithrombotic antipsychotic antihypertensive anticancer antihypertensive antiglaucoma antiglaucoma antibiotic NSAID
1983 2000 2004 1987 2000 2002 1995 1987 2001 1983 1986 2008 1990 1986 2000 2008 1985 2003 2001 1996 1998 1993 1997
19, 36, 40, 23, 36, 38, 31, 23, 37, 19, 22, 44, 26, 22, 36, 44, 21, 39, 37, 32, 34, 29, 33,
315 297 450 328 298 351 338 329 261 315 317 586 300 317 298 587 324 271 262 306 318 333 329
670
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
brotizolam brovincamine fumarate bucillamine bucladesine sodium budipine budralazine bulaquine bunazosin HCl bupropion HCl buserelin acetate buspirone HCl butenafine HCl butibufen butoconazole butoctamide butyl flufenamate cabergoline cadexomer iodine cadralazine calcipotriol camostat mesylate candesartan cilexetil capecitabine captopril carboplatin carperitide carumonam carvedilol caspofungin acetate cefbuperazone sodium cefcapene pivoxil cefdinir cefditoren pivoxil cefepime cefetamet pivoxil HCl cefixime cefmenoxime HCl cefminox sodium cefodizime sodium cefonicid sodium ceforanide cefoselis cefotetan disodium cefotiam hexetil HCl cefozopran HCl
hypnotic cerebral vasodilator immunomodulator cardiostimulant antiParkinsonian antihypertensive antimalarial antihypertensive antidepressant hormone anxiolytic topical antifungal antiinflammatory topical antifungal hypnotic topical antiinflammatory antiprolactin wound healing agent hypertensive antipsoriatic antineoplastic antihypertension antineoplastic antihypertensive agent antibiotic congestive heart failure antibiotic antihypertensive antifungal antibiotic antibiotic antibiotic oral cephalosporin antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic injectable cephalosporin
1983 1986 1987 1984 1997 1983 2000 1985 1989 1984 1985 1992 1992 1986 1984 1983 1993 1983 1988 1991 1985 1997 1998 1982 1986 1995 1988 1991 2001 1985 1997 1991 1994 1993 1992 1987 1983 1987 1990 1984 1984 1998 1984 1991 1995
19, 22, 23, 20, 33, 19, 36, 21, 25, 20, 21, 28, 28, 22, 20, 19, 29, 19, 24, 27, 21, 33, 34, 13, 22, 31, 24, 27, 37, 21, 33, 27, 30, 29, 28, 23, 19, 23, 26, 20, 20, 34, 20, 27, 31,
315 317 329 316 330 315 299 324 310 316 324 327 327 318 316 316 334 316 298 323 325 330 319 086 318 339 298 323 263 325 330 323 297 334 327 329 316 330 300 316 317 319 317 324 339
671
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
cefpimizole cefpiramide sodium cefpirome sulfate cefpodoxime proxetil cefprozil ceftazidime cefteram pivoxil ceftibuten ceftobiprole medocaril cefuroxime axetil cefuzonam sodium celecoxib celiprolol HCl centchroman centoxin cerivastatin certolizumab pegol cetirizine HCl cetrorelix cetuximab cevimeline hydrochloride chenodiol CHF-1301 choline alfoscerate choline fenofibrate cibenzoline ciclesonide cicletanine cidofovir cilazapril cilostazol cimetropium bromide cinacalcet cinildipine cinitapride cinolazepam ciprofibrate ciprofloxacin cisapride cisatracurium besilate citalopram cladribine clarithromycin clevidipine clevudine
antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antiarthritic antihypertensive antiestrogen immunomodulator dyslipidemia crohn’s disease antihistamine female infertility anticancer anti-xerostomia anticholelithogenic antiparkinsonian nootropic dyslipidemia antiarrhythmic asthma, COPD antihypertensive antiviral antihypertensive antithrombotic antispasmodic hyperparathyroidism antihypertensive gastroprokinetic hypnotic hypolipidemic antibacterial gastroprokinetic muscle relaxant antidepressant antineoplastic antibiotic antihypertensive hepatitis B
1987 1985 1992 1989 1992 1983 1987 1992 2008 1987 1987 1999 1983 1991 1991 1997 2008 1987 1999 2003 2000 1983 1999 1990 2008 1985 2005 1988 1996 1990 1988 1985 2004 1995 1990 1993 1985 1986 1988 1995 1989 1993 1990 2008 2007
23, 21, 28, 25, 28, 19, 23, 28, 44, 23, 23, 35, 19, 27, 27, 33, 44, 23, 35, 39, 36, 19, 35, 26, 44, 21, 41, 24, 32, 26, 24, 21, 40, 31, 26, 29, 21, 22, 24, 31, 25, 29, 26, 44, 43,
330 325 328 310 328 316 330 329 589 331 331 335 317 324 325 331 592 331 336 272 299 317 336 300 594 325 443 299 306 301 299 326 451 339 301 334 326 318 299 340 311 335 302 596 466
672
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
clobenoside cloconazole HCl clodronate disodium clofarabine clopidogrel hydrogensulfate cloricromen clospipramine HCl colesevelam hydrochloride colestimide colforsin daropate HCl conivaptan crotelidae polyvalent immune fab cyclosporine cytarabine ocfosfate dabigatran etexilate dalfopristin dapiprazole HCl daptomycin darifenacin darunavir dasatinib decitabine defeiprone deferasirox defibrotide deflazacort delapril delavirdine mesylate denileukin diftitox denopamine deprodone propionate desflurane desloratadine desvenlafaxine dexfenfluramine dexibuprofen dexmedetomidine hydrochloride dexmethylphenidate HCl dexrazoxane dezocine diacerein didanosine dilevalol
vasoprotective topical antifungal calcium regulator anticancer antithrombotic antithrombotic neuroleptic hypolipidemic hypolipidaemic cardiotonic hyponatremia antidote
1988 1986 1986 2005 1998 1991 1991 2000 1999 1999 2006 2001
24, 22, 22, 41, 34, 27, 27, 36, 35, 35, 42, 37,
300 318 319 444 320 325 325 300 337 337 514 263
immunosuppressant antineoplastic anti-coagulant antibiotic antiglaucoma antibiotic urinary incontinence HIV anticancer myelodysplastic syndromes iron chelator chronic iron overload antithrombotic antiinflammatory antihypertensive antiviral anticancer cardiostimulant topical antiinflammatory anesthetic antihistamine antidepressant antiobesity antiinflammatory sedative
1983 1993 2008 1999 1987 2003 2005 2006 2006 2006 1995 2005 1986 1986 1989 1997 1999 1988 1992 1992 2001 2008 1997 1994 2000
19, 29, 44, 35, 23, 39, 41, 42, 42, 42, 31, 41, 22, 22, 25, 33, 35, 24, 28, 28, 37, 44, 33, 30, 36,
317 335 598 338 332 272 445 515 517 519 340 446 319 319 311 331 338 300 329 329 264 600 332 298 301
psychostimulant cardioprotective analgesic antirheumatic antiviral antihypertensive
2002 1992 1991 1985 1991 1989
38, 28, 27, 21, 27, 25,
352 330 326 326 326 311
Cumulative NCE Introduction Index, 1983–2008
673
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
dirithromycin disodium pamidronate divistyramine docarpamine docetaxel dofetilide dolasetron mesylate donepezil HCl dopexamine doripenem dornase alfa dorzolamide HCL dosmalfate doxacurium chloride doxazosin mesylate doxefazepam doxercalciferol doxifluridine doxofylline dronabinol drospirenone drotrecogin alfa droxicam droxidopa duloxetine dutasteride duteplase eberconazole ebastine ebrotidine ecabet sodium eculizumab edaravone efalizumab efavirenz efonidipine egualen sodium eletriptan emedastine difumarate emorfazone emtricitabine enalapril maleate enalaprilat encainide HCl enfuvirtide
antibiotic calcium regulator hypocholesterolemic cardiostimulant antineoplastic antiarrhythmic antiemetic anti-Alzheimer cardiostimulant antibiotic cystic fibrosis antiglaucoma antiulcer muscle relaxant antihypertensive hypnotic vitamin D prohormone antineoplastic bronchodilator antinauseant contraceptive antisepsis antiinflammatory antiparkinsonian antidepressant 5a reductase inhibitor anticougulant antifungal antihistamine antiulcer antiulcerative hemoglobinuria neuroprotective psoriasis antiviral antihypertensive antiulcer antimigraine antiallergic/antiasthmatic analgesic antiviral antihypertensive antihypertensive antiarrhythmic antiviral
1993 1989 1984 1994 1995 2000 1998 1997 1989 2005 1994 1995 2000 1991 1988 1985 1999 1987 1985 1986 2000 2001 1990 1989 2004 2002 1995 2005 1990 1997 1993 2007 2001 2003 1998 1994 2000 2001 1993 1984 2003 1984 1987 1987 2003
29, 336 25, 312 20, 317 30, 298 31, 341 36, 301 34, 321 33, 332 25, 312 41, 448 30, 298 31, 341 36, 302 27, 326 24, 300 21, 326 35, 339 23, 332 21, 327 22, 319 36, 302 37, 265 26, 302 25, 312 40, 452 38, 353 31, 342 41, 449 26 302 33, 333 29, 336 43, 468 37, 265 39, 274 34, 321 30, 299 36, 303 37, 266 29, 336 20, 317 39, 274 20, 317 23, 332 23, 333 39, 275
674
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
enocitabine enoxacin enoxaparin enoximone enprostil entacapone entecavir epalrestat eperisone HCl epidermal growth factor epinastine epirubicin HCl eplerenone epoprostenol sodium eprosartan eptazocine HBr eptilfibatide erdosteine erlotinib ertapenem sodium erythromycin acistrate erythropoietin escitalopram oxolate esmolol HCl esomeprazole magnesium eszopiclone ethyl icosapentate etizolam etodolac etoricoxibe etravirine everolimus exemestane exenatide exifone ezetimibe factor VIIa factor VIII fadrozole HCl falecalcitriol famciclovir famotidine fasudil HCl felbamate felbinac
antineoplastic antibacterial antithrombotic cardiostimulant antiulcer antiparkinsonian antiviral antidiabetic muscle relaxant wound healing agent antiallergic antineoplastic antihypertensive platelet aggreg. inhib. antihypertensive analgesic antithrombotic expectorant anticancer antibacterial antibiotic hematopoetic antidepressant antiarrhythmic gastric antisecretory hypnotic antithrombotic anxiolytic antiinflammatory antiarthritic/analgesic antiviral immunosuppressant anticancer anti-diabetic nootropic hypolipidemic haemophilia hemostatic antineoplastic vitamin D antiviral antiulcer neuroprotective antiepileptic topical antiinflammatory
1983 1986 1987 1988 1985 1998 2005 1992 1983 1987 1994 1984 2003 1983 1997 1987 1999 1995 2004 2002 1988 1988 2002 1987 2000 2005 1990 1984 1985 2002 2008 2004 2000 2005 1988 2002 1996 1992 1995 2001 1994 1985 1995 1993 1986
19, 22, 23, 24, 21, 34, 41, 28, 19, 23, 30, 20, 39, 19, 33, 23, 35, 31, 40, 38, 24, 24, 38, 23, 36, 41, 26, 20, 21, 38, 44, 40, 36, 41, 24, 38, 32, 28, 31, 37, 30, 21, 31, 29, 22,
318 320 333 301 327 322 450 330 318 333 299 318 276 318 333 334 340 342 454 353 301 301 354 334 303 451 303 318 327 355 602 455 304 452 302 355 307 330 342 266 300 327 343 337 320
675
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
felodipine fenbuprol fenoldopam mesylate fenticonazole nitrate fesoterodine fexofenadine filgrastim finasteride fisalamine fleroxacin flomoxef sodium flosequinan fluconazole fludarabine phosphate flumazenil flunoxaprofen fluoxetine HCl flupirtine maleate flurithromycin ethylsuccinate flutamide flutazolam fluticasone furoate fluticasone propionate flutoprazepam flutrimazole flutropium bromide fluvastatin fluvoxamine maleate follitropin alfa follitropin beta fomepizole fomivirsen sodium fondaparinux sodium formestane formoterol fumarate fosamprenavir fosaprepitant dimeglumine foscarnet sodium fosfosal fosfluconazole fosinopril sodium fosphenytoin sodium fotemustine fropenam
antihypertensive choleretic antihypertensive antifungal overactive bladder antiallergic immunostimulant 5a-reductase inhibitor intestinal antiinflammatory antibacterial antibiotic cardiostimulant antifungal antineoplastic benzodiazepine antag. antiinflammatory antidepressant analgesic antibiotic
1988 1983 1998 1987 2008 1996 1991 1992 1984 1992 1988 1992 1988 1991 1987 1987 1986 1985 1997
24, 19, 34, 23, 44, 32, 27, 28, 20, 28, 24, 28, 24, 27, 23, 23, 22, 21, 33,
302 318 322 334 604 307 327 331 318 331 302 331 303 327 335 335 320 328 333
antineoplastic anxiolytic anti-allergy antiinflammatory anxiolytic topical antifungal antitussive hypolipaemic antidepressant fertility enhancer fertility enhancer antidote antiviral antithrombotic antineoplastic bronchodilator antiviral anti-emetic antiviral analgesic antifungal antihypertensive antiepileptic antineoplastic antibiotic
1983 1984 2007 1990 1986 1995 1988 1994 1983 1996 1996 1998 1998 2002 1993 1986 2003 2008 1989 1984 2004 1991 1996 1989 1997
19, 20, 43, 26, 22, 31, 24, 30, 19, 32, 32, 34, 34, 38, 29, 22, 39, 44, 25, 20, 40, 27, 32, 25, 33,
318 318 469 303 320 343 303 300 319 307 308 323 323 356 337 321 277 606 313 319 457 328 308 313 334
676
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
frovatriptan fudosteine fulveristrant gabapentin gadoversetamide gallium nitrate gallopamil HCl galsulfase ganciclovir ganirelix acetate garenoxacin gatilfloxacin gefitinib gemcitabine HCl gemeprost gemifloxacin gemtuzumab ozogamicin gestodene gestrinone glatiramer acetate glimepiride glucagon, rDNA GMDP goserelin granisetron HCl guanadrel sulfate gusperimus halobetasol propionate halofantrine halometasone histrelin hydrocortisone aceponate hydrocortisone butyrate ibandronic acid ibopamine HCl ibudilast ibutilide fumarate ibritunomab tiuxetan icatibant idarubicin HCl idebenone idursulfase
antimigraine expectorant anticancer antiepileptic MRI contrast agent calcium regulator antianginal mucopolysaccharidosis VI antiviral female infertility anti-infective antibiotic antineoplastic antineoplastic abortifacient antibacterial anticancer
2002 2001 2002 1993 2000 1991 1983 2005 1988 2000 2007 1999 2002 1995 1983 2004 2000
38, 37, 38, 29, 36, 27, 19, 41, 24, 36, 43, 35, 38, 31, 19, 40, 36,
357 267 357 338 304 328 319 453 303 305 471 340 358 344 319 458 306
progestogen antiprogestogen Multiple Sclerosis antidiabetic hypoglycemia immunostimulant hormone antiemetic antihypertensive immunosuppressant topical antiinflammatory antimalarial topical antiinflammatory precocious puberty topical antiinflammatory topical antiinflammatory osteoporosis cardiostimulant antiasthmatic antiarrhythmic anticancer hereditary angiodema antineoplastic nootropic mucopolysaccharidosis II (Hunter syndrome) platelet aggreg. inhibitor
1987 1986 1997 1995 1993 1996 1987 1991 1983 1994 1991 1988 1983 1993 1988 1983 1996 1984 1989 1996 2002 2008 1990 1986 2006
23, 22, 33, 31, 29, 32, 23, 27, 19, 30, 27, 24, 19, 29, 24, 19, 32, 20, 25, 32, 38, 44, 26, 22, 42,
335 321 334 344 338 308 336 329 319 300 329 304 320 338 304 320 309 319 313 309 359 608 303 321 520
1992
28, 332
iloprost
677
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
imatinib mesylate imidafenacin imidapril HCl imiglucerase imipenem/cilastatin imiquimod incadronic acid indalpine indeloxazine HCl indinavir sulfate indisetron indobufen influenza virus (live) insulin lispro interferon alfacon-1 interferon gamma-1b interferon, gamma interferon, gamma-1a interferon, b-1a interferon, b-1b interleukin-2 ioflupane ipriflavone irbesartan irinotecan irsogladine isepamicin isofezolac isoxicam isradipine itopride HCl itraconazole ivabradine ivermectin ixabepilone ketanserin ketorolac tromethamine kinetin
antineoplastic overactive bladder antihypertensive Gaucher’s disease antibiotic antiviral osteoporosis antidepressant nootropic antiviral antiemetic antithrombotic antiviral vaccine antidiabetic antiviral immunostimulant antiinflammatory antineoplastic multiple sclerosis multiple sclerosis antineoplastic diagnosis CNS calcium regulator antihypertensive antineoplastic antiulcer antibiotic antiinflammatory antiinflammatory antihypertensive gastroprokinetic antifungal angina antiparasitic anticancer antihypertensive analgesic skin photodamage/ dermatologic antihypertensive anticonvulsant gastric antisecretory antiviral anticonvulsant antiarrhythmic
2001 2007 1993 1994 1985 1997 1997 1983 1988 1996 2004 1984 2003 1996 1997 1991 1989 1992 1996 1993 1989 2000 1989 1997 1994 1989 1988 1984 1983 1989 1995 1988 2006 1987 2007 1985 1990 1999
37, 43, 29, 30, 21, 33, 33, 19, 24, 32, 40, 20, 39, 32, 33, 27, 25, 28, 32, 29, 25, 36, 25, 33, 30, 25, 24, 20, 19, 25, 31, 24, 42, 23, 43, 21, 26, 35,
267 472 339 301 328 335 335 320 304 310 459 319 277 310 336 329 314 332 311 339 314 306 314 336 301 315 305 319 320 315 344 305 522 336 473 328 304 341
1991 2008 2000 1995 1990 2002
27, 44, 36, 31, 26, 38,
330 610 307 345 304 360
lacidipine lacosamide lafutidine lamivudine lamotrigine landiolol
678
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
lanoconazole lanreotide acetate lansoprazole lapatinib laronidase latanoprost lefunomide lenalidomide
antifungal acromegaly antiulcer anticancer mucopolysaccaridosis I antiglaucoma antiarthritic myelodysplastic syndromes, multiple myeloma antibiotic immunostimulant anticoagulant antihyperintensive anticancer hormone nootropic antiasthmatic antiepileptic antiglaucoma local anesthetic
1994 1995 1992 2007 2003 1996 1998 2006
30, 31, 28, 43, 39, 32, 34, 42,
302 345 332 475 278 311 324 523
1987 1986 1997 1997 1996 1984 1986 1999 2000 1985 2000
23, 22, 33, 33, 32, 20, 22, 35, 36, 21, 36,
336 322 336 337 311 319 322 341 307 328 308
antihistamine antihistamine antitussive antibiotic heart failure antiperistaltic antithrombotic antibiotic topical antifungal ADHD antihypertensive antiinflammatory antiallergic ophthalmic antibiotic antimigraine antineoplastic antiviral hypnotic cardiostimulant antibiotic antihistamine NSAID antihypertensive antiallergic ophthalmic
1991 2001 1988 1993 2000 1984 1988 2000 2000 2007 1987 1986 1992 1989 1999 1987 2000 1983 1996 1992 1988 1997 1994 1998
27, 37, 24, 29, 36, 20, 24, 36, 36, 43, 23, 22, 28, 25, 35, 23, 36, 19, 32, 28, 24, 33, 30, 34,
330 268 305 340 308 320 306 309 309 477 337 322 333 315 342 337 310 321 312 333 306 337 302 324
lenampicillin HCl lentinan lepirudin lercanidipine letrazole leuprolide acetate levacecarnine HCl levalbuterol HCl levetiracetam levobunolol HCl levobupivacaine hydrochloride levocabastine HCl levocetirizine levodropropizine levofloxacin levosimendan lidamidine HCl limaprost linezolid liranaftate lisdexamfetamine lisinopril lobenzarit sodium lodoxamide tromethamine lomefloxacin lomerizine HCl lonidamine lopinavir loprazolam mesylate loprinone HCl loracarbef loratadine lornoxicam losartan loteprednol etabonate
679
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
lovastatin loxoprofen sodium lulbiprostone
hypocholesterolemic antiinflammatory chronic idiopathic constipation antifungal anti-inflammatory vaccine bronchodilator hepatoprotective antihypertensive anti-infective – HIV topical antineoplastic vitamin D antihypertensive antidepressant antimalarial hypolipidemic hypocholesterolemic antiarthritic analeptic analgesic carbapenem antibiotic anxiolytic antidepressant opioid-induced constipation anxiolytic antifungal abortifacient antidiabetic gaucher’s disease antidepressant cardiostimulant topical antineoplastic antibiotic antidepressant antiulcer antidiabetic antineoplastic muscle relaxant hepatoprotectant antihistamine immunosuppressant antidepressant idiopathic hypersomnia antihypertensive
1987 1986 2006
23, 337 22, 322 42, 525
2005 2005 1999 1986 1985 1990 2007 1992 2000 1997 1986 1985 1983 1984 1996 1984 1983 1994 1987 1984 2008 1984 2002 1988 1998 2003 1997 1989 1993 1985 1994 1985 2004 1984 1992 1999 1998 1984 1990 1994 1995
41, 41, 35, 22, 21, 26, 43, 28, 36, 33, 22, 21, 19, 20, 32, 20, 19, 30, 23, 20, 44, 20, 38, 24, 34, 39, 33, 25, 29, 21, 30, 21, 40, 20, 28, 35, 34, 20, 26, 30, 31,
luliconazole lumiracoxib Lyme disease mabuterol HCl malotilate manidipine HCl maraviroc masoprocol maxacalcitol mebefradil HCl medifoxamine fumarate mefloquine HCl meglutol melinamide meloxicam mepixanox meptazinol HCl meropenem metaclazepam metapramine methylnaltrexone bromide mexazolam micafungin mifepristone miglitol miglustat milnacipran milrinone miltefosine miokamycin mirtazapine misoprostol mitiglinide mitoxantrone HCl mivacurium chloride mivotilate mizolastine mizoribine moclobemide modafinil moexipril HCl
454 455 342 323 329 304 478 333 310 338 323 329 321 320 312 320 321 303 338 320 612 321 360 306 325 279 338 316 340 329 303 329 460 321 334 343 325 321 305 303 346
680
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
mofezolac mometasone furoate montelukast sodium moricizine HCl mosapride citrate moxifloxacin HCL moxonidine mozavaptan mupirocin muromonab-CD3 muzolimine mycophenolate mofetil mycophenolate sodium nabumetone nadifloxacin nafamostat mesylate nafarelin acetate naftifine HCl naftopidil nalmefene HCl naltrexone HCl naratriptan HCl nartograstim natalizumab nateglinide nazasetron nebivolol nedaplatin nedocromil sodium nefazodone nelarabine nelfinavir mesylate neltenexine nemonapride nepafenac neridronic acide nesiritide neticonazole HCl nevirapine nicorandil nifekalant HCl nilotinib nilutamide nilvadipine nimesulide
analgesic topical antiinflammatory antiasthma antiarrhythmic gastroprokinetic antibiotic antihypertensive hyponatremia topical antibiotic immunosuppressant diuretic immunosuppressant immunosuppressant antiinflammatory topical antibiotic protease inhibitor hormone antifungal dysuria dependence treatment narcotic antagonist antimigraine leukopenia multiple sclerosis antidiabetic antiemetic antihypertensive antineoplastic antiallergic antidepressant anticancer antiviral cystic fibrosis neuroleptic anti-inflammatory calcium regulator congestive heart failure topical antifungal antiviral coronary vasodilator antiarrythmic anticancer – CML antineoplastic antihypertensive antiinflammatory
1994 1987 1998 1990 1998 1999 1991 2006 1985 1986 1983 1995 2003 1985 1993 1986 1990 1984 1999 1995 1984 1997 1994 2004 1999 1994 1997 1995 1986 1994 2006 1997 1993 1991 2005 2002 2001 1993 1996 1984 1999 2007 1987 1989 1985
30, 23, 34, 26, 34, 35, 27, 42, 21, 22, 19, 31, 39, 21, 29, 22, 26, 20, 35, 31, 20, 33, 30, 40, 35, 30, 33, 31, 22, 30, 42, 33, 29, 27, 41, 38, 37, 29, 32, 20, 35, 43, 23, 25, 21,
304 338 326 305 326 343 330 527 330 323 321 346 279 330 340 323 306 321 344 347 322 339 304 462 344 305 339 347 324 305 528 340 341 331 456 361 269 341 313 322 344 480 338 316 330
681
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
nimodipine nimotuzumab nipradilol nisoldipine nitisinone nitrefazole nitrendipine nizatidine nizofenzone fumarate nomegestrol acetate norelgestromin norfloxacin norgestimate OCT-43 octreotide ofloxacin olanzapine olimesartan Medoxomil olopatadine HCl omalizumab omeprazole ondansetron HCl OP-1 orlistat ornoprostil osalazine sodium oseltamivir phosphate oxaliplatin oxaprozin oxcarbazepine oxiconazole nitrate oxiracetam oxitropium bromide ozagrel sodium paclitaxal palifermin paliperidone palonosetron panipenem/betamipron panitumumab pantoprazole sodium parecoxib sodium paricalcitol parnaparin sodium paroxetine
cerebral vasodilator anticancer antihypertensive antihypertensive antityrosinaemia alcohol deterrent hypertensive antiulcer nootropic progestogen contraceptive antibacterial progestogen anticancer antisecretory antibacterial neuroleptic antihypertensive antiallergic allergic asthma antiulcer antiemetic osteoinductor antiobesity antiulcer intestinal antinflamm. antiviral anticancer antiinflammatory anticonvulsant antifungal nootropic bronchodilator antithrombotic antineoplastic mucositis antipsychotic antiemetic carbapenem antibiotic anticancer antiulcer analgesic vitamin D anticoagulant antidepressant
1985 2006 1988 1990 2002 1983 1985 1987 1988 1986 2002 1983 1986 1999 1988 1985 1996 2002 1997 2003 1988 1990 2001 1998 1987 1986 1999 1996 1983 1990 1983 1987 1983 1988 1993 2005 2007 2003 1994 2006 1995 2002 1998 1993 1991
21, 42, 24, 26, 38, 19, 21, 23, 24, 22, 38, 19, 22, 35, 24, 21, 32, 38, 33, 39, 24, 26, 37, 34, 23, 22, 35, 32, 19, 26, 19, 23, 19, 24, 29, 41, 43, 39, 30, 42, 30, 38, 34, 29, 27,
330 529 307 306 361 322 331 339 307 324 362 322 324 345 307 331 313 363 340 280 308 306 269 327 339 324 346 313 322 307 322 339 323 308 342 461 482 281 305 531 306 364 327 342 331
682
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
pazufloxacin pefloxacin mesylate pegademase bovine pegaptanib
antibacterial antibacterial immunostimulant age-related macular degeneration antineoplastic acromegaly anticancer antiasthmatic antiviral antineoplastic antiparkinsonian antihypertensive neuroleptic antithrombotic immunostimulant topical antiinflammatory antiarrhythmic topical antiinflammatory immunosuppressant heart failure antihypertensive antidiabetic antineoplastic idiopathic pulmonary fibrosis antiarrhythmic antiinflammatory hypocholesterolemic antidepressant antiulcer antiulcer antineoplastic adjuvant antifungal antiParkinsonian cognition enhancer anti-diabetic antiasthmatic antilipidemic topical antiinflammatory antiepileptic vulnery anticonvulsant progestogen analgesic antiviral
2002 1985 1990 2005
38, 21, 26, 41,
364 331 307 458
1994 2003 2004 1991 1996 1992 1988 1988 2001 1987 1993 1984 1991 1984 2002 1994 1987 1999 1988 2008 1994 1988 2003 1997 1987 1994 1993 2006 1997 1993 2005 1995 1989 1986 2004 1996 1985 1983 1986 1994
30, 39, 40, 27, 32, 28, 24, 24, 37, 23, 29, 20, 27, 20, 38, 30, 23, 35, 24, 44, 30, 24, 39, 33, 23, 30, 29, 42, 33, 29, 41, 31, 25, 22, 40, 32, 21, 19, 22, 30,
306 281 463 331 314 334 308 309 270 340 343 322 332 322 365 307 340 346 309 614 307 309 282 341 340 307 343 532 341 343 460 347 316 325 464 314 331 323 325 308
pegaspargase pegvisomant pemetrexed pemirolast potassium penciclovir pentostatin pergolide mesylate perindopril perospirone HCL picotamide pidotimod piketoprofen pilsicainide HCl pimaprofen pimecrolimus pimobendan pinacidil pioglitazone HCL pirarubicin pirfenidone pirmenol piroxicam cinnamate pitavastatin pivagabine plaunotol polaprezinc porfimer sodium posaconazole pramipexole HCl pramiracetam H2SO4 pramlintide pranlukast pravastatin prednicarbate pregabalin prezatide copper acetate progabide promegestrone propacetamol HCl propagermanium
683
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
propentofylline propionate propiverine HCl propofol prulifloxacin pumactant quazepam quetiapine fumarate quinagolide quinapril quinfamide quinupristin rabeprazole sodium raloxifene HCl raltegravir raltitrexed ramatroban ramelteon ramipril ramosetron ranibizumab
cerebral vasodilator urologic anesthetic antibacterial lung surfactant hypnotic neuroleptic hyperprolactinemia antihypertensive amebicide antibiotic gastric antisecretory osteoporosis anti-infective – HIV anticancer antiallergic insomnia antihypertensive antiemetic age-related macular degeneration antineoplastic antiulcer angina muscle relaxant parkinson’s disease antiulcer antidepressant analgesic antipsychotic antidiabetic antiallergic anti-infective fibrinolytic anticoagulant antibacterial antibacterial antibiotic antibiotic hypnotic antihypertensive genetic autoinflammatory syndromes neuroprotective antiviral
1988 1992 1986 2002 1994 1985 1997 1994 1989 1984 1999 1998 1998 2007 1996 2000 2005 1989 1996 2006
24, 28, 22, 38, 30, 21, 33, 30, 25, 20, 35, 34, 34, 43, 32, 36, 41, 25, 32, 42,
310 335 325 366 308 332 341 309 317 322 338 328 328 484 315 311 462 317 315 534
1987 1995 2006 1999 2005 1990 1997 1996 1990 1998 1987 2007 1996 1993 1992 1988 1985 1987 1989 1988 2008
23, 31, 42, 35, 41, 26, 33, 32, 26, 34, 23, 43, 32, 29, 28, 24, 21, 23, 25, 24, 44,
341 348 535 347 464 308 342 316 308 329 341 486 316 344 335 310 332 341 317 310 615
1996 1987
32, 316 23, 342
ranimustine ranitidine bismuth citrate ranolazine rapacuronium bromide rasagiline rebamipide reboxetine remifentanil HCl remoxipride HCl repaglinide repirinast retapamulin reteplase reviparin sodium rifabutin rifapentine rifaximin rifaximin rilmazafone rilmenidine rilonacept riluzole rimantadine HCl
684
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
rimexolone rimonabant risedronate sodium risperidone ritonavir rivaroxaban
antiinflammatory anti-obesity osteoporosis neuroleptic antiviral anticoagulant, venous thromboembolism anti-Alzheimer antimigraine neuromuscular blocker antiarthritic antibiotic antithrombocytopenic immunostimulant hypolipidemic antiParkinsonian anesthetic antiulcer antidiabetic hypocholesterolemic parkinson’s disease antiulcer antiulcer anticonvulsant antibacterial antiallergic antibiotic bronchodilator
1995 2006 1998 1993 1996 2008
31, 42, 34, 29, 32, 44,
348 537 330 344 317 617
1997 1998 1994 1999 1986 2008 1991 1986 1996 1996 1985 1999 2003 2006 1986 1987 2007 1992 2003 1989 1990
33, 34, 30, 35, 22, 44, 27, 22, 32, 32, 21, 35, 39, 42, 22, 23, 43, 28, 39, 25, 26,
342 330 309 347 325 619 332 326 317 318 332 348 283 538 326 342 488 335 284 318 308
hyperphenylalaninemia antiviral immunostimulant platelet antiaggregant immunostimulant antiasthmatic topical antifungal neuroleptic antihistamine antidepressant antidepressant anesthetic antiobesity male sexual dysfunction dysuria hypocholesterolemic
1992 1995 1991 1993 1985 1995 1992 1996 1987 1989 1990 1990 1998 1998 2006 1988
8, 336 31 349 27, 332 29, 344 22, 326 31, 349 28, 336 32, 318 23, 342 25, 318 26, 309 26, 309 34, 331 34, 331 42, 540 24, 311
rivastigmin rizatriptan benzoate rocuronium bromide rofecoxib rokitamycin romiplostim romurtide ronafibrate ropinirole HCl ropivacaine rosaprostol rosiglitazone maleate rosuvastatin rotigotine roxatidine acetate HCl roxithromycin rufinamide rufloxacin HCl rupatadine fumarate RV-11 salmeterol hydroxynaphthoate sapropterin HCl saquinavir mesvlate sargramostim sarpogrelate HCl schizophyllan seratrodast sertaconazole nitrate sertindole setastine HCl setiptiline setraline HCl sevoflurane sibutramine sildenafil citrate silodosin simvastatin
685
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
sitafloxacin hydrate sitagliptin sitaxsentan sivelestat SKI-2053R sobuzoxane sodium cellulose PO4 sofalcone solifenacin somatomedin-1
antibacterial antidiabetic pulmonary hypertension anti-inflammatory anticancer antineoplastic hypocalciuric antiulcer pollakiuria growth hormone insensitivity growth hormone hormone anticancer antiviral antibiotic antihypertensive antiulcer antiviral osteoporosis chelator analgesic reversal of neuromuscular blockade b-lactamase inhibitor topical antifungal antibiotic antimigraine anticancer antiallergic analgesic respiratory surfactant topical antipsoriatic Alzheimer’s disease immunosuppressant male sexual dysfunction antiglaucoma anticancer antiParkinsonian CNS stimulant anticancer antiprostatic hypertrophy anxiolytic anticancer antiallergic
2008 2006 2006 2002 1999 1994 1983 1984 2004 1994
44, 42, 42, 38, 35, 30, 19, 20, 40, 30,
621 541 543 366 348 310 323 323 466 310
1994 1987 2005 1993 1993 1995 1987 1994 2004 1991 1983 2008
30, 23, 41, 29, 29, 31, 23, 30, 40, 27, 19, 44,
310 343 466 345 345 349 343 311 466 333 323 623
1986 1985 1987 1991 2006 1995 1983 1987 1993 1993 1993 2003 2008 2004 1996 2000 2005 1993 1996 1999 1990
22, 21, 23, 27, 42, 31, 19, 23, 29, 29, 29, 39, 44, 40, 32, 36, 41, 29, 32, 35, 26,
326 332 343 333 544 350 324 344 346 346 347 284 625 469 318 311 467 347 319 349 309
somatotropin somatropin sorafenib sorivudine sparfloxacin spirapril HCl spizofurone stavudine strontium ranelate succimer sufentanil sugammadex sulbactam sodium sulconizole nitrate sultamycillin tosylate sumatriptan succinate sunitinib suplatast tosilate suprofen surfactant TA tacalcitol tacrine HCl tacrolimus tadalafil tafluprost talaporfin sodium talipexole taltirelin tamibarotene tamsulosin HCl tandospirone tasonermin tazanolast
686
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
tazarotene tazobactam sodium tegaserod maleate teicoplanin telbivudine telithromycin telmesteine telmisartan temafloxacin HCl temocapril temocillin disodium temoporphin
antipsoriasis b-lactamase inhibitor irritable bowel syndrome antibacterial hepatitis B antibiotic mucolytic antihypertensive antibacterial antihypertensive antibiotic antineoplastic/ photosensitizer anticancer anticancer antiviral
1997 1992 2001 1988 2006 2001 1992 1999 1991 1994 1984 2002
33, 28, 37, 24, 42, 37, 28, 35, 27, 30, 20, 38,
1999 2007 2001
35, 349 43, 490 37, 271
antiinflammatory antiulcer antihypertensive antifungal antifungal antihypertensive hemostat anticoagulant
1987 1984 1984 1991 1983 1987 2008 2008
23, 20, 20, 27, 19, 23, 44, 44,
344 323 323 334 324 344 627 628
immunomodulator antiepileptic antihypertensive antidepressant anabolic antibiotic antihypertensive Paget’s disease neuroleptic nasal decongestant antifungal urolithiasis bronchodilator HIV antispasmodic antiarrhythmic subarachnoid hemorrhage antithrombotic
1985 1996 1988 1983 1988 2005 1992 1995 1984 1988 1983 1989 2002 2005 1984 1990 1995
21, 32, 24, 19, 24, 41, 28, 31, 20, 24, 19, 25, 38, 41, 20, 26, 31,
333 319 311 324 312 468 337 350 323 312 324 318 368 470 324 310 351
1998
34, 332
temozolomide temsirolimus tenofovir disoproxil fumarate tenoxicam teprenone terazosin HCl terbinafine HCl terconazole tertatolol HCl thrombin alfa thrombomodulin (recombinant) thymopentin tiagabine tiamenidine HCl tianeptine sodium tibolone tigecycline tilisolol HCl tiludronate disodium timiperone tinazoline tioconazole tiopronin tiotropium bromide tipranavir tiquizium bromide tiracizine HCl tirilazad mesylate tirofiban HCl
343 336 270 311 546 271 337 349 334 311 323 367
687
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
tiropramide HCl tizanidine tolcapone toloxatone tolrestat topiramate topotecan HCl torasemide toremifene tositumomab tosufloxacin tosylate trabectedin trandolapril travoprost treprostinil sodium tretinoin tocoferil trientine HCl trimazosin HCl trimegestone trimetrexate glucuronate
antispasmodic muscle relaxant antiParkinsonian antidepressant antidiabetic antiepileptic anticancer diuretic antineoplastic anticancer antibacterial anticancer antihypertensive antiglaucoma antihypertensive antiulcer chelator antihypertensive progestogen Pneumocystis carinii pneumonia antidiabetic antiemetic antibiotic
1983 1984 1997 1984 1989 1995 1996 1993 1989 2003 1990 2007 1993 2001 2002 1993 1986 1985 2001 1994
19, 20, 33, 20, 25, 31, 32, 29, 25, 39, 26, 43, 29, 37, 38, 29, 22, 21, 37, 30,
1997 1992 1998
33, 344 28, 337 34, 332
antiulcer immunostimulant erectile dysfunction antiglaucoma
1986 1987 2005 1994
22, 23, 41, 30,
327 345 472 312
antiviral antiarthritic antiviral anticancer antihypertensive male sexual dysfunction nicotine-dependence antidepressant photosensitizer cardiostimulant anticonvulsant antidiabetic antineoplastic antidiabetic antifungal
1995 2002 2001 1999 1996 2003 2006 1994 2000 1990 1989 2007 1989 1994 2002
31, 38, 37, 35, 32, 39, 42, 30, 36, 26, 25, 43, 25, 30, 38,
352 369 273 350 320 286 547 312 312 310 319 494 320 313 370
troglitazone tropisetron trovafloxacin mesylate troxipide ubenimex udenafil unoprostone isopropyl ester valaciclovir HCl vadecoxib vaglancirclovir HCL valrubicin valsartan vardenafil varenicline venlafaxine verteporfin vesnarinone vigabatrin vildagliptin vinorelbine voglibose voriconazole
324 324 343 324 319 351 320 348 319 285 310 492 348 272 368 348 327 333 273 312
688
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
vorinostat xamoterol fumarate ximelagatran zafirlukast zalcitabine zaleplon zaltoprofen zanamivir ziconotide zidovudine zileuton zinostatin stimalamer ziprasidone hydrochloride zofenopril calcium zoledronate disodium zolpidem hemitartrate zomitriptan zonisamide zopiclone zuclopenthixol acetate
anticancer cardiotonic anticoagulant antiasthma antiviral hypnotic antiinflammatory antiviral severe chronic pain antiviral antiasthma antineoplastic neuroleptic antihypertensive hypercalcemia hypnotic antimigraine anticonvulsant hypnotic antipsychotic
2006 1988 2004 1996 1992 1999 1993 1999 2005 1987 1997 1994 2000 2000 2000 1988 1997 1989 1986 1987
42, 24, 40, 32, 28, 35, 29, 35, 41, 23, 33, 30, 36, 36, 36, 24, 33, 25, 22, 23,
549 312 470 321 338 351 349 352 473 345 344 313 312 313 314 313 345 320 327 345
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
abacavir sulfate abarelix abatacept acarbose aceclofenac acemannan acetohydroxamic acid acetorphan acipimox acitretin acrivastine actarit adalimumab adamantanium bromide adefovir dipivoxil adrafinil AF-2259 afloqualone agalsidase alfa alacepril alclometasone dipropionate alefacept alemtuzumab alendronate sodium alfentanil HCl alfuzosin HCl alglucerase alglucosidase alfa aliskiren alitretinoin alminoprofen almotriptan anakinra anidulafungin alosetron hydrochloride alpha-1 antitrypsin alpidem alpiropride alteplase
antiviral anticancer rheumatoid arthritis antidiabetic antiinflammatory wound healing agent hypoammonuric antidiarrheal hypolipidemic antipsoriatic antihistamine antirheumatic rheumatoid arthritis antiseptic antiviral psychostimulant antiinflammatory muscle relaxant fabry’s disease antihypertensive topical antiinflammatory plaque psoriasis anticancer osteoporosis analgesic antihypertensive enzyme Pompe disease antihypertensive anticancer analgesic antimigraine antiarthritic antifungal irritable bowel syndrome protease inhibitor anxiolytic antimigraine thrombolytic
1999 2004 2006 1990 1992 2001 1983 1993 1985 1989 1988 1994 2003 1984 2002 1986 1987 1983 2001 1988 1985 2003 2001 1993 1983 1988 1991 2006 2007 1999 1983 2000 2001 2006 2000 1988 1991 1988 1987
35, 40, 42, 26, 28, 37, 19, 29, 21, 25, 24, 30, 39, 20, 38, 22, 23, 19, 37, 24, 21, 39, 37, 29, 19, 24, 27, 42, 43, 35, 19, 36, 37, 42, 36, 24, 27, 24, 23,
333 446 509 297 325 259 313 332 323 309 295 296 267 315 348 315 325 313 259 296 323 267 260 332 314 296 321 511 461 333 314 295 261 512 295 297 322 296 326
667
668
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
alvimopan ambrisentan
post-operative ileus pulmonary arterial hypertension antiinflammatory cytoprotective topical antiinflammatory antipsychotic antiasthmatic antihypertensive topical antifungal antihypertensive antiinflammatory antiviral cardiotonic antineoplastic antineoplastic antiinflammatory hematological antineoplastic anticancer adjuvant cognition enhancer antidote
2008 2007
44, 584 43, 463
1986 1995 1990 1986 1987 1990 1991 1988 1994 1999 1983 2002 1987 1993 1997 1995 1994 1993 2002
22, 31, 26, 22, 23, 26, 27, 24, 30, 35, 19, 38, 23, 29, 33, 31, 30, 29, 38,
315 338 298 316 327 298 322 297 296 334 314 349 327 332 328 338 296 333 350
1987 1988 2003 1987 1996 1990 2007
23, 24, 39, 23, 32, 26, 43,
326 297 268 326 306 298 465
1990 1999 2002 1986 2000 1987 1987 1983 1985 2003 2003
26, 35, 38, 22, 36, 23, 23, 19, 21, 39, 39,
299 335 350 316 296 327 328 314 324 269 270
1997 2000
33, 328 36, 297
amfenac sodium amifostine aminoprofen amisulpride amlexanox amlodipine besylate amorolfine HCl amosulalol ampiroxicam amprenavir amrinone amrubicin HCl amsacrine amtolmetin guacil anagrelide HCl anastrozole angiotensin II aniracetam anti-digoxin polyclonal antibody APD apraclonidine HCl aprepitant APSAC aranidipine arbekacin arformoterol argatroban arglabin aripiprazole arotinolol HCl arteether artemisinin aspoxicillin astemizole astromycin sulfate atazanavir atomoxetine atorvastatin calcium atosiban
calcium regulator antiglaucoma antiemetic thrombolytic antihypertensive antibiotic chronic obstructive pulmonary disease antithromobotic anticancer neuroleptic antihypertensive antimalarial antimalarial antibiotic antihistamine antibiotic antiviral attention deficit hyperactivity disorder dyslipidemia preterm labor
669
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
atovaquone auranofin azacitidine azelnidipine azelaic acid azelastine HCl azithromycin azosemide aztreonam balofloxacin balsalazide disodium bambuterol barnidipine HCl beclobrate befunolol HCl belotecan benazepril HCl benexate HCl benidipine HCl beraprost sodium betamethasone butyrate prospinate betaxolol HCl betotastine besilate bevacizumab bevantolol HCl bexarotene biapenem bicalutamide bifemelane HCl bimatoprost binfonazole binifibrate biolimus drug-eluting stent bisantrene HCl bisoprolol fumarate bivalirudin blonanserin bopindolol bortezomib bosentan brimonidine brinzolamide brodimoprin bromfenac sodium
antiparasitic chrysotherapeutic anticancer antihypertensive antiacne antihistamine antibiotic diuretic antibiotic antibacterial ulcerative colitis bronchodilator antihypertensive hypolipidemic antiglaucoma anticancer antihypertensive antiulcer antihypertensive platelet aggreg. inhibitor topical antiinflammatory
1992 1983 2004 2003 1989 1986 1988 1986 1984 2002 1997 1990 1992 1986 1983 2004 1990 1987 1991 1992 1994
28, 19, 40, 39, 25, 22, 24, 22, 20, 38, 33, 26, 28, 22, 19, 40, 26, 23, 27, 28, 30,
326 143 447 270 310 316 298 316 315 351 329 299 326 317 315 449 299 328 322 326 297
antihypertensive antiallergic anticancer antihypertensive anticancer antibacterial antineoplastic nootropic antiglaucoma hypnotic hypolipidemic anti-restenotic antineoplastic antihypertensive antithrombotic antipsychotic antihypertensive anticancer antihypertensive antiglaucoma antiglaucoma antibiotic NSAID
1983 2000 2004 1987 2000 2002 1995 1987 2001 1983 1986 2008 1990 1986 2000 2008 1985 2003 2001 1996 1998 1993 1997
19, 36, 40, 23, 36, 38, 31, 23, 37, 19, 22, 44, 26, 22, 36, 44, 21, 39, 37, 32, 34, 29, 33,
315 297 450 328 298 351 338 329 261 315 317 586 300 317 298 587 324 271 262 306 318 333 329
670
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
brotizolam brovincamine fumarate bucillamine bucladesine sodium budipine budralazine bulaquine bunazosin HCl bupropion HCl buserelin acetate buspirone HCl butenafine HCl butibufen butoconazole butoctamide butyl flufenamate cabergoline cadexomer iodine cadralazine calcipotriol camostat mesylate candesartan cilexetil capecitabine captopril carboplatin carperitide carumonam carvedilol caspofungin acetate cefbuperazone sodium cefcapene pivoxil cefdinir cefditoren pivoxil cefepime cefetamet pivoxil HCl cefixime cefmenoxime HCl cefminox sodium cefodizime sodium cefonicid sodium ceforanide cefoselis cefotetan disodium cefotiam hexetil HCl cefozopran HCl
hypnotic cerebral vasodilator immunomodulator cardiostimulant antiParkinsonian antihypertensive antimalarial antihypertensive antidepressant hormone anxiolytic topical antifungal antiinflammatory topical antifungal hypnotic topical antiinflammatory antiprolactin wound healing agent hypertensive antipsoriatic antineoplastic antihypertension antineoplastic antihypertensive agent antibiotic congestive heart failure antibiotic antihypertensive antifungal antibiotic antibiotic antibiotic oral cephalosporin antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic injectable cephalosporin
1983 1986 1987 1984 1997 1983 2000 1985 1989 1984 1985 1992 1992 1986 1984 1983 1993 1983 1988 1991 1985 1997 1998 1982 1986 1995 1988 1991 2001 1985 1997 1991 1994 1993 1992 1987 1983 1987 1990 1984 1984 1998 1984 1991 1995
19, 22, 23, 20, 33, 19, 36, 21, 25, 20, 21, 28, 28, 22, 20, 19, 29, 19, 24, 27, 21, 33, 34, 13, 22, 31, 24, 27, 37, 21, 33, 27, 30, 29, 28, 23, 19, 23, 26, 20, 20, 34, 20, 27, 31,
315 317 329 316 330 315 299 324 310 316 324 327 327 318 316 316 334 316 298 323 325 330 319 086 318 339 298 323 263 325 330 323 297 334 327 329 316 330 300 316 317 319 317 324 339
671
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
cefpimizole cefpiramide sodium cefpirome sulfate cefpodoxime proxetil cefprozil ceftazidime cefteram pivoxil ceftibuten ceftobiprole medocaril cefuroxime axetil cefuzonam sodium celecoxib celiprolol HCl centchroman centoxin cerivastatin certolizumab pegol cetirizine HCl cetrorelix cetuximab cevimeline hydrochloride chenodiol CHF-1301 choline alfoscerate choline fenofibrate cibenzoline ciclesonide cicletanine cidofovir cilazapril cilostazol cimetropium bromide cinacalcet cinildipine cinitapride cinolazepam ciprofibrate ciprofloxacin cisapride cisatracurium besilate citalopram cladribine clarithromycin clevidipine clevudine
antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antibiotic antiarthritic antihypertensive antiestrogen immunomodulator dyslipidemia crohn’s disease antihistamine female infertility anticancer anti-xerostomia anticholelithogenic antiparkinsonian nootropic dyslipidemia antiarrhythmic asthma, COPD antihypertensive antiviral antihypertensive antithrombotic antispasmodic hyperparathyroidism antihypertensive gastroprokinetic hypnotic hypolipidemic antibacterial gastroprokinetic muscle relaxant antidepressant antineoplastic antibiotic antihypertensive hepatitis B
1987 1985 1992 1989 1992 1983 1987 1992 2008 1987 1987 1999 1983 1991 1991 1997 2008 1987 1999 2003 2000 1983 1999 1990 2008 1985 2005 1988 1996 1990 1988 1985 2004 1995 1990 1993 1985 1986 1988 1995 1989 1993 1990 2008 2007
23, 21, 28, 25, 28, 19, 23, 28, 44, 23, 23, 35, 19, 27, 27, 33, 44, 23, 35, 39, 36, 19, 35, 26, 44, 21, 41, 24, 32, 26, 24, 21, 40, 31, 26, 29, 21, 22, 24, 31, 25, 29, 26, 44, 43,
330 325 328 310 328 316 330 329 589 331 331 335 317 324 325 331 592 331 336 272 299 317 336 300 594 325 443 299 306 301 299 326 451 339 301 334 326 318 299 340 311 335 302 596 466
672
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
clobenoside cloconazole HCl clodronate disodium clofarabine clopidogrel hydrogensulfate cloricromen clospipramine HCl colesevelam hydrochloride colestimide colforsin daropate HCl conivaptan crotelidae polyvalent immune fab cyclosporine cytarabine ocfosfate dabigatran etexilate dalfopristin dapiprazole HCl daptomycin darifenacin darunavir dasatinib decitabine defeiprone deferasirox defibrotide deflazacort delapril delavirdine mesylate denileukin diftitox denopamine deprodone propionate desflurane desloratadine desvenlafaxine dexfenfluramine dexibuprofen dexmedetomidine hydrochloride dexmethylphenidate HCl dexrazoxane dezocine diacerein didanosine dilevalol
vasoprotective topical antifungal calcium regulator anticancer antithrombotic antithrombotic neuroleptic hypolipidemic hypolipidaemic cardiotonic hyponatremia antidote
1988 1986 1986 2005 1998 1991 1991 2000 1999 1999 2006 2001
24, 22, 22, 41, 34, 27, 27, 36, 35, 35, 42, 37,
300 318 319 444 320 325 325 300 337 337 514 263
immunosuppressant antineoplastic anti-coagulant antibiotic antiglaucoma antibiotic urinary incontinence HIV anticancer myelodysplastic syndromes iron chelator chronic iron overload antithrombotic antiinflammatory antihypertensive antiviral anticancer cardiostimulant topical antiinflammatory anesthetic antihistamine antidepressant antiobesity antiinflammatory sedative
1983 1993 2008 1999 1987 2003 2005 2006 2006 2006 1995 2005 1986 1986 1989 1997 1999 1988 1992 1992 2001 2008 1997 1994 2000
19, 29, 44, 35, 23, 39, 41, 42, 42, 42, 31, 41, 22, 22, 25, 33, 35, 24, 28, 28, 37, 44, 33, 30, 36,
317 335 598 338 332 272 445 515 517 519 340 446 319 319 311 331 338 300 329 329 264 600 332 298 301
psychostimulant cardioprotective analgesic antirheumatic antiviral antihypertensive
2002 1992 1991 1985 1991 1989
38, 28, 27, 21, 27, 25,
352 330 326 326 326 311
Cumulative NCE Introduction Index, 1983–2008
673
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
dirithromycin disodium pamidronate divistyramine docarpamine docetaxel dofetilide dolasetron mesylate donepezil HCl dopexamine doripenem dornase alfa dorzolamide HCL dosmalfate doxacurium chloride doxazosin mesylate doxefazepam doxercalciferol doxifluridine doxofylline dronabinol drospirenone drotrecogin alfa droxicam droxidopa duloxetine dutasteride duteplase eberconazole ebastine ebrotidine ecabet sodium eculizumab edaravone efalizumab efavirenz efonidipine egualen sodium eletriptan emedastine difumarate emorfazone emtricitabine enalapril maleate enalaprilat encainide HCl enfuvirtide
antibiotic calcium regulator hypocholesterolemic cardiostimulant antineoplastic antiarrhythmic antiemetic anti-Alzheimer cardiostimulant antibiotic cystic fibrosis antiglaucoma antiulcer muscle relaxant antihypertensive hypnotic vitamin D prohormone antineoplastic bronchodilator antinauseant contraceptive antisepsis antiinflammatory antiparkinsonian antidepressant 5a reductase inhibitor anticougulant antifungal antihistamine antiulcer antiulcerative hemoglobinuria neuroprotective psoriasis antiviral antihypertensive antiulcer antimigraine antiallergic/antiasthmatic analgesic antiviral antihypertensive antihypertensive antiarrhythmic antiviral
1993 1989 1984 1994 1995 2000 1998 1997 1989 2005 1994 1995 2000 1991 1988 1985 1999 1987 1985 1986 2000 2001 1990 1989 2004 2002 1995 2005 1990 1997 1993 2007 2001 2003 1998 1994 2000 2001 1993 1984 2003 1984 1987 1987 2003
29, 336 25, 312 20, 317 30, 298 31, 341 36, 301 34, 321 33, 332 25, 312 41, 448 30, 298 31, 341 36, 302 27, 326 24, 300 21, 326 35, 339 23, 332 21, 327 22, 319 36, 302 37, 265 26, 302 25, 312 40, 452 38, 353 31, 342 41, 449 26 302 33, 333 29, 336 43, 468 37, 265 39, 274 34, 321 30, 299 36, 303 37, 266 29, 336 20, 317 39, 274 20, 317 23, 332 23, 333 39, 275
674
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
enocitabine enoxacin enoxaparin enoximone enprostil entacapone entecavir epalrestat eperisone HCl epidermal growth factor epinastine epirubicin HCl eplerenone epoprostenol sodium eprosartan eptazocine HBr eptilfibatide erdosteine erlotinib ertapenem sodium erythromycin acistrate erythropoietin escitalopram oxolate esmolol HCl esomeprazole magnesium eszopiclone ethyl icosapentate etizolam etodolac etoricoxibe etravirine everolimus exemestane exenatide exifone ezetimibe factor VIIa factor VIII fadrozole HCl falecalcitriol famciclovir famotidine fasudil HCl felbamate felbinac
antineoplastic antibacterial antithrombotic cardiostimulant antiulcer antiparkinsonian antiviral antidiabetic muscle relaxant wound healing agent antiallergic antineoplastic antihypertensive platelet aggreg. inhib. antihypertensive analgesic antithrombotic expectorant anticancer antibacterial antibiotic hematopoetic antidepressant antiarrhythmic gastric antisecretory hypnotic antithrombotic anxiolytic antiinflammatory antiarthritic/analgesic antiviral immunosuppressant anticancer anti-diabetic nootropic hypolipidemic haemophilia hemostatic antineoplastic vitamin D antiviral antiulcer neuroprotective antiepileptic topical antiinflammatory
1983 1986 1987 1988 1985 1998 2005 1992 1983 1987 1994 1984 2003 1983 1997 1987 1999 1995 2004 2002 1988 1988 2002 1987 2000 2005 1990 1984 1985 2002 2008 2004 2000 2005 1988 2002 1996 1992 1995 2001 1994 1985 1995 1993 1986
19, 22, 23, 24, 21, 34, 41, 28, 19, 23, 30, 20, 39, 19, 33, 23, 35, 31, 40, 38, 24, 24, 38, 23, 36, 41, 26, 20, 21, 38, 44, 40, 36, 41, 24, 38, 32, 28, 31, 37, 30, 21, 31, 29, 22,
318 320 333 301 327 322 450 330 318 333 299 318 276 318 333 334 340 342 454 353 301 301 354 334 303 451 303 318 327 355 602 455 304 452 302 355 307 330 342 266 300 327 343 337 320
675
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
felodipine fenbuprol fenoldopam mesylate fenticonazole nitrate fesoterodine fexofenadine filgrastim finasteride fisalamine fleroxacin flomoxef sodium flosequinan fluconazole fludarabine phosphate flumazenil flunoxaprofen fluoxetine HCl flupirtine maleate flurithromycin ethylsuccinate flutamide flutazolam fluticasone furoate fluticasone propionate flutoprazepam flutrimazole flutropium bromide fluvastatin fluvoxamine maleate follitropin alfa follitropin beta fomepizole fomivirsen sodium fondaparinux sodium formestane formoterol fumarate fosamprenavir fosaprepitant dimeglumine foscarnet sodium fosfosal fosfluconazole fosinopril sodium fosphenytoin sodium fotemustine fropenam
antihypertensive choleretic antihypertensive antifungal overactive bladder antiallergic immunostimulant 5a-reductase inhibitor intestinal antiinflammatory antibacterial antibiotic cardiostimulant antifungal antineoplastic benzodiazepine antag. antiinflammatory antidepressant analgesic antibiotic
1988 1983 1998 1987 2008 1996 1991 1992 1984 1992 1988 1992 1988 1991 1987 1987 1986 1985 1997
24, 19, 34, 23, 44, 32, 27, 28, 20, 28, 24, 28, 24, 27, 23, 23, 22, 21, 33,
302 318 322 334 604 307 327 331 318 331 302 331 303 327 335 335 320 328 333
antineoplastic anxiolytic anti-allergy antiinflammatory anxiolytic topical antifungal antitussive hypolipaemic antidepressant fertility enhancer fertility enhancer antidote antiviral antithrombotic antineoplastic bronchodilator antiviral anti-emetic antiviral analgesic antifungal antihypertensive antiepileptic antineoplastic antibiotic
1983 1984 2007 1990 1986 1995 1988 1994 1983 1996 1996 1998 1998 2002 1993 1986 2003 2008 1989 1984 2004 1991 1996 1989 1997
19, 20, 43, 26, 22, 31, 24, 30, 19, 32, 32, 34, 34, 38, 29, 22, 39, 44, 25, 20, 40, 27, 32, 25, 33,
318 318 469 303 320 343 303 300 319 307 308 323 323 356 337 321 277 606 313 319 457 328 308 313 334
676
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
frovatriptan fudosteine fulveristrant gabapentin gadoversetamide gallium nitrate gallopamil HCl galsulfase ganciclovir ganirelix acetate garenoxacin gatilfloxacin gefitinib gemcitabine HCl gemeprost gemifloxacin gemtuzumab ozogamicin gestodene gestrinone glatiramer acetate glimepiride glucagon, rDNA GMDP goserelin granisetron HCl guanadrel sulfate gusperimus halobetasol propionate halofantrine halometasone histrelin hydrocortisone aceponate hydrocortisone butyrate ibandronic acid ibopamine HCl ibudilast ibutilide fumarate ibritunomab tiuxetan icatibant idarubicin HCl idebenone idursulfase
antimigraine expectorant anticancer antiepileptic MRI contrast agent calcium regulator antianginal mucopolysaccharidosis VI antiviral female infertility anti-infective antibiotic antineoplastic antineoplastic abortifacient antibacterial anticancer
2002 2001 2002 1993 2000 1991 1983 2005 1988 2000 2007 1999 2002 1995 1983 2004 2000
38, 37, 38, 29, 36, 27, 19, 41, 24, 36, 43, 35, 38, 31, 19, 40, 36,
357 267 357 338 304 328 319 453 303 305 471 340 358 344 319 458 306
progestogen antiprogestogen Multiple Sclerosis antidiabetic hypoglycemia immunostimulant hormone antiemetic antihypertensive immunosuppressant topical antiinflammatory antimalarial topical antiinflammatory precocious puberty topical antiinflammatory topical antiinflammatory osteoporosis cardiostimulant antiasthmatic antiarrhythmic anticancer hereditary angiodema antineoplastic nootropic mucopolysaccharidosis II (Hunter syndrome) platelet aggreg. inhibitor
1987 1986 1997 1995 1993 1996 1987 1991 1983 1994 1991 1988 1983 1993 1988 1983 1996 1984 1989 1996 2002 2008 1990 1986 2006
23, 22, 33, 31, 29, 32, 23, 27, 19, 30, 27, 24, 19, 29, 24, 19, 32, 20, 25, 32, 38, 44, 26, 22, 42,
335 321 334 344 338 308 336 329 319 300 329 304 320 338 304 320 309 319 313 309 359 608 303 321 520
1992
28, 332
iloprost
677
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
imatinib mesylate imidafenacin imidapril HCl imiglucerase imipenem/cilastatin imiquimod incadronic acid indalpine indeloxazine HCl indinavir sulfate indisetron indobufen influenza virus (live) insulin lispro interferon alfacon-1 interferon gamma-1b interferon, gamma interferon, gamma-1a interferon, b-1a interferon, b-1b interleukin-2 ioflupane ipriflavone irbesartan irinotecan irsogladine isepamicin isofezolac isoxicam isradipine itopride HCl itraconazole ivabradine ivermectin ixabepilone ketanserin ketorolac tromethamine kinetin
antineoplastic overactive bladder antihypertensive Gaucher’s disease antibiotic antiviral osteoporosis antidepressant nootropic antiviral antiemetic antithrombotic antiviral vaccine antidiabetic antiviral immunostimulant antiinflammatory antineoplastic multiple sclerosis multiple sclerosis antineoplastic diagnosis CNS calcium regulator antihypertensive antineoplastic antiulcer antibiotic antiinflammatory antiinflammatory antihypertensive gastroprokinetic antifungal angina antiparasitic anticancer antihypertensive analgesic skin photodamage/ dermatologic antihypertensive anticonvulsant gastric antisecretory antiviral anticonvulsant antiarrhythmic
2001 2007 1993 1994 1985 1997 1997 1983 1988 1996 2004 1984 2003 1996 1997 1991 1989 1992 1996 1993 1989 2000 1989 1997 1994 1989 1988 1984 1983 1989 1995 1988 2006 1987 2007 1985 1990 1999
37, 43, 29, 30, 21, 33, 33, 19, 24, 32, 40, 20, 39, 32, 33, 27, 25, 28, 32, 29, 25, 36, 25, 33, 30, 25, 24, 20, 19, 25, 31, 24, 42, 23, 43, 21, 26, 35,
267 472 339 301 328 335 335 320 304 310 459 319 277 310 336 329 314 332 311 339 314 306 314 336 301 315 305 319 320 315 344 305 522 336 473 328 304 341
1991 2008 2000 1995 1990 2002
27, 44, 36, 31, 26, 38,
330 610 307 345 304 360
lacidipine lacosamide lafutidine lamivudine lamotrigine landiolol
678
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
lanoconazole lanreotide acetate lansoprazole lapatinib laronidase latanoprost lefunomide lenalidomide
antifungal acromegaly antiulcer anticancer mucopolysaccaridosis I antiglaucoma antiarthritic myelodysplastic syndromes, multiple myeloma antibiotic immunostimulant anticoagulant antihyperintensive anticancer hormone nootropic antiasthmatic antiepileptic antiglaucoma local anesthetic
1994 1995 1992 2007 2003 1996 1998 2006
30, 31, 28, 43, 39, 32, 34, 42,
302 345 332 475 278 311 324 523
1987 1986 1997 1997 1996 1984 1986 1999 2000 1985 2000
23, 22, 33, 33, 32, 20, 22, 35, 36, 21, 36,
336 322 336 337 311 319 322 341 307 328 308
antihistamine antihistamine antitussive antibiotic heart failure antiperistaltic antithrombotic antibiotic topical antifungal ADHD antihypertensive antiinflammatory antiallergic ophthalmic antibiotic antimigraine antineoplastic antiviral hypnotic cardiostimulant antibiotic antihistamine NSAID antihypertensive antiallergic ophthalmic
1991 2001 1988 1993 2000 1984 1988 2000 2000 2007 1987 1986 1992 1989 1999 1987 2000 1983 1996 1992 1988 1997 1994 1998
27, 37, 24, 29, 36, 20, 24, 36, 36, 43, 23, 22, 28, 25, 35, 23, 36, 19, 32, 28, 24, 33, 30, 34,
330 268 305 340 308 320 306 309 309 477 337 322 333 315 342 337 310 321 312 333 306 337 302 324
lenampicillin HCl lentinan lepirudin lercanidipine letrazole leuprolide acetate levacecarnine HCl levalbuterol HCl levetiracetam levobunolol HCl levobupivacaine hydrochloride levocabastine HCl levocetirizine levodropropizine levofloxacin levosimendan lidamidine HCl limaprost linezolid liranaftate lisdexamfetamine lisinopril lobenzarit sodium lodoxamide tromethamine lomefloxacin lomerizine HCl lonidamine lopinavir loprazolam mesylate loprinone HCl loracarbef loratadine lornoxicam losartan loteprednol etabonate
679
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
lovastatin loxoprofen sodium lulbiprostone
hypocholesterolemic antiinflammatory chronic idiopathic constipation antifungal anti-inflammatory vaccine bronchodilator hepatoprotective antihypertensive anti-infective – HIV topical antineoplastic vitamin D antihypertensive antidepressant antimalarial hypolipidemic hypocholesterolemic antiarthritic analeptic analgesic carbapenem antibiotic anxiolytic antidepressant opioid-induced constipation anxiolytic antifungal abortifacient antidiabetic gaucher’s disease antidepressant cardiostimulant topical antineoplastic antibiotic antidepressant antiulcer antidiabetic antineoplastic muscle relaxant hepatoprotectant antihistamine immunosuppressant antidepressant idiopathic hypersomnia antihypertensive
1987 1986 2006
23, 337 22, 322 42, 525
2005 2005 1999 1986 1985 1990 2007 1992 2000 1997 1986 1985 1983 1984 1996 1984 1983 1994 1987 1984 2008 1984 2002 1988 1998 2003 1997 1989 1993 1985 1994 1985 2004 1984 1992 1999 1998 1984 1990 1994 1995
41, 41, 35, 22, 21, 26, 43, 28, 36, 33, 22, 21, 19, 20, 32, 20, 19, 30, 23, 20, 44, 20, 38, 24, 34, 39, 33, 25, 29, 21, 30, 21, 40, 20, 28, 35, 34, 20, 26, 30, 31,
luliconazole lumiracoxib Lyme disease mabuterol HCl malotilate manidipine HCl maraviroc masoprocol maxacalcitol mebefradil HCl medifoxamine fumarate mefloquine HCl meglutol melinamide meloxicam mepixanox meptazinol HCl meropenem metaclazepam metapramine methylnaltrexone bromide mexazolam micafungin mifepristone miglitol miglustat milnacipran milrinone miltefosine miokamycin mirtazapine misoprostol mitiglinide mitoxantrone HCl mivacurium chloride mivotilate mizolastine mizoribine moclobemide modafinil moexipril HCl
454 455 342 323 329 304 478 333 310 338 323 329 321 320 312 320 321 303 338 320 612 321 360 306 325 279 338 316 340 329 303 329 460 321 334 343 325 321 305 303 346
680
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
mofezolac mometasone furoate montelukast sodium moricizine HCl mosapride citrate moxifloxacin HCL moxonidine mozavaptan mupirocin muromonab-CD3 muzolimine mycophenolate mofetil mycophenolate sodium nabumetone nadifloxacin nafamostat mesylate nafarelin acetate naftifine HCl naftopidil nalmefene HCl naltrexone HCl naratriptan HCl nartograstim natalizumab nateglinide nazasetron nebivolol nedaplatin nedocromil sodium nefazodone nelarabine nelfinavir mesylate neltenexine nemonapride nepafenac neridronic acide nesiritide neticonazole HCl nevirapine nicorandil nifekalant HCl nilotinib nilutamide nilvadipine nimesulide
analgesic topical antiinflammatory antiasthma antiarrhythmic gastroprokinetic antibiotic antihypertensive hyponatremia topical antibiotic immunosuppressant diuretic immunosuppressant immunosuppressant antiinflammatory topical antibiotic protease inhibitor hormone antifungal dysuria dependence treatment narcotic antagonist antimigraine leukopenia multiple sclerosis antidiabetic antiemetic antihypertensive antineoplastic antiallergic antidepressant anticancer antiviral cystic fibrosis neuroleptic anti-inflammatory calcium regulator congestive heart failure topical antifungal antiviral coronary vasodilator antiarrythmic anticancer – CML antineoplastic antihypertensive antiinflammatory
1994 1987 1998 1990 1998 1999 1991 2006 1985 1986 1983 1995 2003 1985 1993 1986 1990 1984 1999 1995 1984 1997 1994 2004 1999 1994 1997 1995 1986 1994 2006 1997 1993 1991 2005 2002 2001 1993 1996 1984 1999 2007 1987 1989 1985
30, 23, 34, 26, 34, 35, 27, 42, 21, 22, 19, 31, 39, 21, 29, 22, 26, 20, 35, 31, 20, 33, 30, 40, 35, 30, 33, 31, 22, 30, 42, 33, 29, 27, 41, 38, 37, 29, 32, 20, 35, 43, 23, 25, 21,
304 338 326 305 326 343 330 527 330 323 321 346 279 330 340 323 306 321 344 347 322 339 304 462 344 305 339 347 324 305 528 340 341 331 456 361 269 341 313 322 344 480 338 316 330
681
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
nimodipine nimotuzumab nipradilol nisoldipine nitisinone nitrefazole nitrendipine nizatidine nizofenzone fumarate nomegestrol acetate norelgestromin norfloxacin norgestimate OCT-43 octreotide ofloxacin olanzapine olimesartan Medoxomil olopatadine HCl omalizumab omeprazole ondansetron HCl OP-1 orlistat ornoprostil osalazine sodium oseltamivir phosphate oxaliplatin oxaprozin oxcarbazepine oxiconazole nitrate oxiracetam oxitropium bromide ozagrel sodium paclitaxal palifermin paliperidone palonosetron panipenem/betamipron panitumumab pantoprazole sodium parecoxib sodium paricalcitol parnaparin sodium paroxetine
cerebral vasodilator anticancer antihypertensive antihypertensive antityrosinaemia alcohol deterrent hypertensive antiulcer nootropic progestogen contraceptive antibacterial progestogen anticancer antisecretory antibacterial neuroleptic antihypertensive antiallergic allergic asthma antiulcer antiemetic osteoinductor antiobesity antiulcer intestinal antinflamm. antiviral anticancer antiinflammatory anticonvulsant antifungal nootropic bronchodilator antithrombotic antineoplastic mucositis antipsychotic antiemetic carbapenem antibiotic anticancer antiulcer analgesic vitamin D anticoagulant antidepressant
1985 2006 1988 1990 2002 1983 1985 1987 1988 1986 2002 1983 1986 1999 1988 1985 1996 2002 1997 2003 1988 1990 2001 1998 1987 1986 1999 1996 1983 1990 1983 1987 1983 1988 1993 2005 2007 2003 1994 2006 1995 2002 1998 1993 1991
21, 42, 24, 26, 38, 19, 21, 23, 24, 22, 38, 19, 22, 35, 24, 21, 32, 38, 33, 39, 24, 26, 37, 34, 23, 22, 35, 32, 19, 26, 19, 23, 19, 24, 29, 41, 43, 39, 30, 42, 30, 38, 34, 29, 27,
330 529 307 306 361 322 331 339 307 324 362 322 324 345 307 331 313 363 340 280 308 306 269 327 339 324 346 313 322 307 322 339 323 308 342 461 482 281 305 531 306 364 327 342 331
682
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
pazufloxacin pefloxacin mesylate pegademase bovine pegaptanib
antibacterial antibacterial immunostimulant age-related macular degeneration antineoplastic acromegaly anticancer antiasthmatic antiviral antineoplastic antiparkinsonian antihypertensive neuroleptic antithrombotic immunostimulant topical antiinflammatory antiarrhythmic topical antiinflammatory immunosuppressant heart failure antihypertensive antidiabetic antineoplastic idiopathic pulmonary fibrosis antiarrhythmic antiinflammatory hypocholesterolemic antidepressant antiulcer antiulcer antineoplastic adjuvant antifungal antiParkinsonian cognition enhancer anti-diabetic antiasthmatic antilipidemic topical antiinflammatory antiepileptic vulnery anticonvulsant progestogen analgesic antiviral
2002 1985 1990 2005
38, 21, 26, 41,
364 331 307 458
1994 2003 2004 1991 1996 1992 1988 1988 2001 1987 1993 1984 1991 1984 2002 1994 1987 1999 1988 2008 1994 1988 2003 1997 1987 1994 1993 2006 1997 1993 2005 1995 1989 1986 2004 1996 1985 1983 1986 1994
30, 39, 40, 27, 32, 28, 24, 24, 37, 23, 29, 20, 27, 20, 38, 30, 23, 35, 24, 44, 30, 24, 39, 33, 23, 30, 29, 42, 33, 29, 41, 31, 25, 22, 40, 32, 21, 19, 22, 30,
306 281 463 331 314 334 308 309 270 340 343 322 332 322 365 307 340 346 309 614 307 309 282 341 340 307 343 532 341 343 460 347 316 325 464 314 331 323 325 308
pegaspargase pegvisomant pemetrexed pemirolast potassium penciclovir pentostatin pergolide mesylate perindopril perospirone HCL picotamide pidotimod piketoprofen pilsicainide HCl pimaprofen pimecrolimus pimobendan pinacidil pioglitazone HCL pirarubicin pirfenidone pirmenol piroxicam cinnamate pitavastatin pivagabine plaunotol polaprezinc porfimer sodium posaconazole pramipexole HCl pramiracetam H2SO4 pramlintide pranlukast pravastatin prednicarbate pregabalin prezatide copper acetate progabide promegestrone propacetamol HCl propagermanium
683
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
propentofylline propionate propiverine HCl propofol prulifloxacin pumactant quazepam quetiapine fumarate quinagolide quinapril quinfamide quinupristin rabeprazole sodium raloxifene HCl raltegravir raltitrexed ramatroban ramelteon ramipril ramosetron ranibizumab
cerebral vasodilator urologic anesthetic antibacterial lung surfactant hypnotic neuroleptic hyperprolactinemia antihypertensive amebicide antibiotic gastric antisecretory osteoporosis anti-infective – HIV anticancer antiallergic insomnia antihypertensive antiemetic age-related macular degeneration antineoplastic antiulcer angina muscle relaxant parkinson’s disease antiulcer antidepressant analgesic antipsychotic antidiabetic antiallergic anti-infective fibrinolytic anticoagulant antibacterial antibacterial antibiotic antibiotic hypnotic antihypertensive genetic autoinflammatory syndromes neuroprotective antiviral
1988 1992 1986 2002 1994 1985 1997 1994 1989 1984 1999 1998 1998 2007 1996 2000 2005 1989 1996 2006
24, 28, 22, 38, 30, 21, 33, 30, 25, 20, 35, 34, 34, 43, 32, 36, 41, 25, 32, 42,
310 335 325 366 308 332 341 309 317 322 338 328 328 484 315 311 462 317 315 534
1987 1995 2006 1999 2005 1990 1997 1996 1990 1998 1987 2007 1996 1993 1992 1988 1985 1987 1989 1988 2008
23, 31, 42, 35, 41, 26, 33, 32, 26, 34, 23, 43, 32, 29, 28, 24, 21, 23, 25, 24, 44,
341 348 535 347 464 308 342 316 308 329 341 486 316 344 335 310 332 341 317 310 615
1996 1987
32, 316 23, 342
ranimustine ranitidine bismuth citrate ranolazine rapacuronium bromide rasagiline rebamipide reboxetine remifentanil HCl remoxipride HCl repaglinide repirinast retapamulin reteplase reviparin sodium rifabutin rifapentine rifaximin rifaximin rilmazafone rilmenidine rilonacept riluzole rimantadine HCl
684
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
rimexolone rimonabant risedronate sodium risperidone ritonavir rivaroxaban
antiinflammatory anti-obesity osteoporosis neuroleptic antiviral anticoagulant, venous thromboembolism anti-Alzheimer antimigraine neuromuscular blocker antiarthritic antibiotic antithrombocytopenic immunostimulant hypolipidemic antiParkinsonian anesthetic antiulcer antidiabetic hypocholesterolemic parkinson’s disease antiulcer antiulcer anticonvulsant antibacterial antiallergic antibiotic bronchodilator
1995 2006 1998 1993 1996 2008
31, 42, 34, 29, 32, 44,
348 537 330 344 317 617
1997 1998 1994 1999 1986 2008 1991 1986 1996 1996 1985 1999 2003 2006 1986 1987 2007 1992 2003 1989 1990
33, 34, 30, 35, 22, 44, 27, 22, 32, 32, 21, 35, 39, 42, 22, 23, 43, 28, 39, 25, 26,
342 330 309 347 325 619 332 326 317 318 332 348 283 538 326 342 488 335 284 318 308
hyperphenylalaninemia antiviral immunostimulant platelet antiaggregant immunostimulant antiasthmatic topical antifungal neuroleptic antihistamine antidepressant antidepressant anesthetic antiobesity male sexual dysfunction dysuria hypocholesterolemic
1992 1995 1991 1993 1985 1995 1992 1996 1987 1989 1990 1990 1998 1998 2006 1988
8, 336 31 349 27, 332 29, 344 22, 326 31, 349 28, 336 32, 318 23, 342 25, 318 26, 309 26, 309 34, 331 34, 331 42, 540 24, 311
rivastigmin rizatriptan benzoate rocuronium bromide rofecoxib rokitamycin romiplostim romurtide ronafibrate ropinirole HCl ropivacaine rosaprostol rosiglitazone maleate rosuvastatin rotigotine roxatidine acetate HCl roxithromycin rufinamide rufloxacin HCl rupatadine fumarate RV-11 salmeterol hydroxynaphthoate sapropterin HCl saquinavir mesvlate sargramostim sarpogrelate HCl schizophyllan seratrodast sertaconazole nitrate sertindole setastine HCl setiptiline setraline HCl sevoflurane sibutramine sildenafil citrate silodosin simvastatin
685
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
sitafloxacin hydrate sitagliptin sitaxsentan sivelestat SKI-2053R sobuzoxane sodium cellulose PO4 sofalcone solifenacin somatomedin-1
antibacterial antidiabetic pulmonary hypertension anti-inflammatory anticancer antineoplastic hypocalciuric antiulcer pollakiuria growth hormone insensitivity growth hormone hormone anticancer antiviral antibiotic antihypertensive antiulcer antiviral osteoporosis chelator analgesic reversal of neuromuscular blockade b-lactamase inhibitor topical antifungal antibiotic antimigraine anticancer antiallergic analgesic respiratory surfactant topical antipsoriatic Alzheimer’s disease immunosuppressant male sexual dysfunction antiglaucoma anticancer antiParkinsonian CNS stimulant anticancer antiprostatic hypertrophy anxiolytic anticancer antiallergic
2008 2006 2006 2002 1999 1994 1983 1984 2004 1994
44, 42, 42, 38, 35, 30, 19, 20, 40, 30,
621 541 543 366 348 310 323 323 466 310
1994 1987 2005 1993 1993 1995 1987 1994 2004 1991 1983 2008
30, 23, 41, 29, 29, 31, 23, 30, 40, 27, 19, 44,
310 343 466 345 345 349 343 311 466 333 323 623
1986 1985 1987 1991 2006 1995 1983 1987 1993 1993 1993 2003 2008 2004 1996 2000 2005 1993 1996 1999 1990
22, 21, 23, 27, 42, 31, 19, 23, 29, 29, 29, 39, 44, 40, 32, 36, 41, 29, 32, 35, 26,
326 332 343 333 544 350 324 344 346 346 347 284 625 469 318 311 467 347 319 349 309
somatotropin somatropin sorafenib sorivudine sparfloxacin spirapril HCl spizofurone stavudine strontium ranelate succimer sufentanil sugammadex sulbactam sodium sulconizole nitrate sultamycillin tosylate sumatriptan succinate sunitinib suplatast tosilate suprofen surfactant TA tacalcitol tacrine HCl tacrolimus tadalafil tafluprost talaporfin sodium talipexole taltirelin tamibarotene tamsulosin HCl tandospirone tasonermin tazanolast
686
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
tazarotene tazobactam sodium tegaserod maleate teicoplanin telbivudine telithromycin telmesteine telmisartan temafloxacin HCl temocapril temocillin disodium temoporphin
antipsoriasis b-lactamase inhibitor irritable bowel syndrome antibacterial hepatitis B antibiotic mucolytic antihypertensive antibacterial antihypertensive antibiotic antineoplastic/ photosensitizer anticancer anticancer antiviral
1997 1992 2001 1988 2006 2001 1992 1999 1991 1994 1984 2002
33, 28, 37, 24, 42, 37, 28, 35, 27, 30, 20, 38,
1999 2007 2001
35, 349 43, 490 37, 271
antiinflammatory antiulcer antihypertensive antifungal antifungal antihypertensive hemostat anticoagulant
1987 1984 1984 1991 1983 1987 2008 2008
23, 20, 20, 27, 19, 23, 44, 44,
344 323 323 334 324 344 627 628
immunomodulator antiepileptic antihypertensive antidepressant anabolic antibiotic antihypertensive Paget’s disease neuroleptic nasal decongestant antifungal urolithiasis bronchodilator HIV antispasmodic antiarrhythmic subarachnoid hemorrhage antithrombotic
1985 1996 1988 1983 1988 2005 1992 1995 1984 1988 1983 1989 2002 2005 1984 1990 1995
21, 32, 24, 19, 24, 41, 28, 31, 20, 24, 19, 25, 38, 41, 20, 26, 31,
333 319 311 324 312 468 337 350 323 312 324 318 368 470 324 310 351
1998
34, 332
temozolomide temsirolimus tenofovir disoproxil fumarate tenoxicam teprenone terazosin HCl terbinafine HCl terconazole tertatolol HCl thrombin alfa thrombomodulin (recombinant) thymopentin tiagabine tiamenidine HCl tianeptine sodium tibolone tigecycline tilisolol HCl tiludronate disodium timiperone tinazoline tioconazole tiopronin tiotropium bromide tipranavir tiquizium bromide tiracizine HCl tirilazad mesylate tirofiban HCl
343 336 270 311 546 271 337 349 334 311 323 367
687
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
tiropramide HCl tizanidine tolcapone toloxatone tolrestat topiramate topotecan HCl torasemide toremifene tositumomab tosufloxacin tosylate trabectedin trandolapril travoprost treprostinil sodium tretinoin tocoferil trientine HCl trimazosin HCl trimegestone trimetrexate glucuronate
antispasmodic muscle relaxant antiParkinsonian antidepressant antidiabetic antiepileptic anticancer diuretic antineoplastic anticancer antibacterial anticancer antihypertensive antiglaucoma antihypertensive antiulcer chelator antihypertensive progestogen Pneumocystis carinii pneumonia antidiabetic antiemetic antibiotic
1983 1984 1997 1984 1989 1995 1996 1993 1989 2003 1990 2007 1993 2001 2002 1993 1986 1985 2001 1994
19, 20, 33, 20, 25, 31, 32, 29, 25, 39, 26, 43, 29, 37, 38, 29, 22, 21, 37, 30,
1997 1992 1998
33, 344 28, 337 34, 332
antiulcer immunostimulant erectile dysfunction antiglaucoma
1986 1987 2005 1994
22, 23, 41, 30,
327 345 472 312
antiviral antiarthritic antiviral anticancer antihypertensive male sexual dysfunction nicotine-dependence antidepressant photosensitizer cardiostimulant anticonvulsant antidiabetic antineoplastic antidiabetic antifungal
1995 2002 2001 1999 1996 2003 2006 1994 2000 1990 1989 2007 1989 1994 2002
31, 38, 37, 35, 32, 39, 42, 30, 36, 26, 25, 43, 25, 30, 38,
352 369 273 350 320 286 547 312 312 310 319 494 320 313 370
troglitazone tropisetron trovafloxacin mesylate troxipide ubenimex udenafil unoprostone isopropyl ester valaciclovir HCl vadecoxib vaglancirclovir HCL valrubicin valsartan vardenafil varenicline venlafaxine verteporfin vesnarinone vigabatrin vildagliptin vinorelbine voglibose voriconazole
324 324 343 324 319 351 320 348 319 285 310 492 348 272 368 348 327 333 273 312
688
Cumulative NCE Introduction Index, 1983–2008
GENERAL NAME
INDICATION
YEAR INTRO.
ARMC VOL., PAGE
vorinostat xamoterol fumarate ximelagatran zafirlukast zalcitabine zaleplon zaltoprofen zanamivir ziconotide zidovudine zileuton zinostatin stimalamer ziprasidone hydrochloride zofenopril calcium zoledronate disodium zolpidem hemitartrate zomitriptan zonisamide zopiclone zuclopenthixol acetate
anticancer cardiotonic anticoagulant antiasthma antiviral hypnotic antiinflammatory antiviral severe chronic pain antiviral antiasthma antineoplastic neuroleptic antihypertensive hypercalcemia hypnotic antimigraine anticonvulsant hypnotic antipsychotic
2006 1988 2004 1996 1992 1999 1993 1999 2005 1987 1997 1994 2000 2000 2000 1988 1997 1989 1986 1987
42, 24, 40, 32, 28, 35, 29, 35, 41, 23, 33, 30, 36, 36, 36, 24, 33, 25, 22, 23,
549 312 470 321 338 351 349 352 473 345 344 313 312 313 314 313 345 320 327 345