HLA-A and -B alleles and cytokine polymorphism frequencies in a Chinese population from Singapore

HLA-A and -B alleles and cytokine polymorphism frequencies in a Chinese population from Singapore

1072 HLA allele Frequency (%) Gene frequency B*27 3.6 0.018 B*35 33.9 0.183 B*38 0.9 0.005 B*40 6.3 0.031 B*41 0.9 0.005 B*42 1.8 0.009 B*44 2.7 0.01...

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HLA allele Frequency (%) Gene frequency B*27 3.6 0.018 B*35 33.9 0.183 B*38 0.9 0.005 B*40 6.3 0.031 B*41 0.9 0.005 B*42 1.8 0.009 B*44 2.7 0.013 B*49 7.1 0.036 B*50 0.9 0.005 B*51 8.9 0.048 B*5103 0.9 0.005 B*52 2.7 0.013 B*53 21.4 0.111 B*56 0.9 0.005 B*57 6.3 0.031 B*58 9.8 0.049 B*78 16.1 0.076 DRB1*0101 2.2 0.011 DRB1*0102 4.4 0.022 DRB1*0301 4.4 0.022 DRB1*0302 6.7 0.033 DRB1*04 15.6 0.078 DRB1*0701 2.2 0.011 DRB1*0802 2.2 0.011 DRB1*0804 6.7 0.033 DRB1*0806 2.2 0.011 DRB1*090102 6.7 0.033 DRB1*1001 33.3 0.189 DRB1*1101 6.7 0.033 DRB1*1102 26.7 0.144 DRB1*1301 11.1 0.056 DRB1*1302 8.9 0.044 DRB1*1303 6.7 0.033 DRB1*1304 40 0.211 DRB1*1503 4.4 0.022

HLA-A and -B Alleles and Cytokine Polymorphism Frequencies in a Chinese Population from Singapore F. Williams and D. Middleton* Northern Ireland Regional Histocompatibility & Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland E-mail: *[email protected] This population from Singapore, Latitude 1.2N Longitude 103.4E consisted of 149 Oriental individuals. The individuals Human Immunology 65 (2004) © American Society for Histocompatibility and Immunogenetics, 2004 Published by Elsevier Inc.

were drawn from an urban environment and HLA alleles and cytokine polymorphisms were determined using sequence specific oligonucleotide probes. Only 83 individuals tested for cytokine. The results have previously been published in Human Immunology 61, 1048 –52, 2000 and, Human Immunology 62, 645– 650, 2001. It was not possible to differentiate HLA-A*0301 from A*0303N and B*0705 from B*0706. Frequencies are given under A*0301 and B*0705 respectively. Human Immunology 65, 1072–1076 (2004). © American Society for Histocompatibility and Immunogenetics, 2004. Published by Elsevier Inc. Allele Frequency (%) Gene frequency A*01 0.7 0.003 A*0101 0.7 0.003 A*0102 0 0 A*02 57 0.346 A*0201 19.5 0.104 A*0202 0 0 A*0203 12.8 0.067 A*0204 0 0 A*0205 0 0 A*0206 7.4 0.040 A*0207 24.2 0.131 A*0208 0 0 A*0209 0 0 A*0210 0.7 0.003 A*0211 0 0 A*0212 0 0 A*0213 0 0 A*0214 0 0 A*0215N 0 0 A*0216 0 0 A*0217 0 0 A*0218 0 0 A*0219 0 0 A*0220 0 0 A*0221 0 0 A*0222 0 0 A*0224 0 0 A*0225 0 0 A*0226 0 0 A*03 1.3 0.007 A*0301 1.3 0.007 A*0302 0 0 A*11 51.7 0.295 A*1101 47.7 0.265 A*1102 6 0.03 A*1103 0 0 A*1104 0 0 A*23 0 0 A*2301 0 0 A*24 31.5 0.175 A*24020101 28.2 0.154 A*24020102L 0 0 A*2403 0.7 0.003 A*2404 0 0 A*2405 0 0 A*2406 0 0 A*2407 2 0.01 0198-8859/04/$–see front matter

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Allele A*2408 A*2409N A*2410 A*2411N A*2413 A*2414 A*25 A*2501 A*2502 A*26 A*2601 A*2602 A*2603 A*2604 A*2605 A*2606 A*2607 A*2608 A*2609 A*29 A*2901 A*2902 A*2903 A*30 A*3001 A*3002 A*3003 A*3004 A*31 A*310102 A*32 A*3201 A*3202 A*33 A*3301 A*3303 A*34 A*3401 A*3402 A*36 A*3601 A*43 A*4301 A*66 A*6601 A*6602 A*6603 A*68 A*680101 A*680102 A*6802 A*6803 A*6804 A*6805 A*69 A*6901 A*74

Frequency (%) Gene frequency 0.7 0.003 0 0 0.7 0.003 0 0 0 0 0 0 0 0 0 0 0 0 4 0.02 4 0.02 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0.01 2 0.01 0 0 0 0 2.7 0.013 2.7 0.013 0 0 0 0 0 0 3.4 0.017 3.4 0.017 1.3 0.007 1.3 0.007 0 0 18.8 0.101 0 0 18.8 0.101 0.7 0.003 0.7 0.003 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.7 0.003

Allele A*80 A*8001 B*07 B*0702 B*0703 B*0704 B*0705 B*0706 B*0707 B*0708 B*0709 B*0710 B*0711 B*0712 B*0713 B*0720 B*08 B*0801 B*0802 B*0803 B*0804 B*0805 B*0806 B*13 B*1301 B*1302 B*1303 B*1304 B*14 B*1401 B*1402 B*1403 B*1404 B*1405 B*15 B*1501 B*15010102N B*1502 B*1503 B*1504 B*1505 B*1506 B*1507 B*1508 B*1509 B*1510 B*1511 B*1512 B*1513 B*1514 B*1515 B*1516 B*1517 B*1518 B*1519 B*1520

Frequency (%) Gene frequency 0 0 0 0 5.4 2 0 0 3.4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 19.5 16.8 3.4 0 0 0 0 0 0 0 0 23.5 8.1 0 11.4 0 0 0 0.7 0 0 0 0 2 0 0.7 0 0 0 0 0 0 0

0.027 0.01 0 0 0.017 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.101 0.084 0.017 0 0 0 0 0 0 0 0 0.117 0.04 0 0.057 0 0 0 0.003 0 0 0 0 0.01 0 0.003 0 0 0 0 0 0 0

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Allele B*1521 B*1523 B*1524 B*1525 B*1526N B*1527 B*1528 B*1529 B*1530 B*1531 B*1532 B*1533 B*1534 B*1535 B*1536 B*1537 B*1538 B*1539 B*1540 B*1543 B*1544 B*1545 B*1546 B*1547 B*18 B*1801 B*1802 B*1803 B*1804 B*1805 B*1807 B*27 B*2701 B*2702 B*2703 B*2704 B*2705 B*2706 B*2707 B*2708 B*2709 B*2710 B*2711 B*2712 B*2714 B*35 B*3501 B*3502 B*3503 B*3504 B*3505 B*3506 B*3507 B*3508 B*3509 B*3510 B*3511

Frequency (%) Gene frequency 0 0 0 0 0 0 0 0 0 0 0.7 0.003 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0.01 1.3 0.007 0.7 0.003 0 0 0 0 0 0 0 0 2.7 0.013 0 0 0 0 0 0 2 0.01 0 0 0.7 0.003 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0.03 4 0.02 0 0 0.7 0.003 0 0 1.3 0.007 0 0 0 0 0 0 0 0 0 0 0 0

Allele B*3512 B*3513 B*3514 B*3515 B*3516 B*3517 B*3518 B*3519 B*3520 B*3521 B*3522 B*3523 B*3524 B*3525 B*3526 B*3528 B*3529 B*3530 B*3531 B*3532 B*3533 B*37 B*3701 B*3702 B*38 B*3801 B*3802 B*3803 B*39 B*3901 B*3902 B*3904 B*3905 B*3906 B*3907 B*3908 B*3909 B*3910 B*3911 B*3912 B*3914 B*3915 B*3924 B*40 B*4001 B*4002 B*4003 B*4004 B*4005 B*4006 B*4007 B*4008 B*4009 B*4010 B*4011 B*4012 B*4013

Frequency (%) Gene frequency 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.7 0.003 0.7 0.003 0 0 9.4 0.047 0 0 9.4 0.047 0 0 5.4 0.027 4.7 0.024 0 0 0 0 0.7 0.003 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 31.5 0.191 28.2 0.175 3.4 0.017 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

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Allele B*4014 B*4015 B*4016 B*4018 B*4019 B*4020 B*41 B*4101 B*4102 B*4103 B*42 B*4201 B*4202 B*44 B*4402 B*4403 B*4404 B*4405 B*4406 B*4407 B*4408 B*4409 B*4410 B*4411 B*4415 B*45 B*4501 B*4502 B*46 B*4601 B*47 B*4701 B*4702 B*4703 B*48 B*4801 B*4802 B*4803 B*4804 B*49 B*4901 B*50 B*5001 B*5002 B*51 B*5101 B*5102 B*5103 B*5104 B*5105 B*5106 B*5107 B*5108 B*5109 B*5110 B*5113 B*5114

Frequency (%) Gene frequency 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.7 0.003 0 0 0.7 0.003 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 23.5 0.134 23.5 0.134 0 0 0 0 0 0 0 0 2.7 0.017 2.7 0.017 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 18.8 0.101 15.4 0.084 2.7 0.013 0 0 0 0 0 0 0 0 0.7 0.003 0 0 0 0 0 0 0 0 0 0

Allele B*5115 B*5116 B*52 B*5201 B*53 B*5301 B*5302 B*5303 B*5304 B*54 B*5401 B*55 B*5501 B*5502 B*5503 B*5504 B*5505 B*56 B*5601 B*5602 B*5603 B*5604 B*5605 B*57 B*5701 B*5702 B*5703 B*5704 B*5705 B*58 B*5801 B*5802 B*59 B*5901 B*67 B*6701 B*73 B*7301 B*78 B*7801 B*7802 B*7803 B*81 B*8101 B*82 B*8201

Frequency (%) Gene frequency 0 0 0 0 2 0.01 2 0.01 0 0 0 0 0 0 0 0 0 0 3.4 0.017 3.4 0.017 6 0.03 0 0 6 0.03 0 0 0 0 0 0 3.4 0.017 2.7 0.013 0.7 0.003 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20.1 0.104 20.1 0.104 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Allele Frequency (%) A*0201-B*1301 1.6 A*0201-B*3501 1 A*0201-B*4001 2.5 A*0201-B*4601 1.3 A*0203-B*3802 3.4 A*0206-B*5502 1 A*0207-B*1502 1.7 A*0207-B*4601 7.1 A*1101-B*1301 3.3

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Allele Frequency (%) A*1101-B*1502 2.7 A*1101-B*4001 8.7 A*1101-B*4601 2.5 A*1101-B*5101 2 A*1101-B*5801 1.3 A*2402-B*1301 2.4 A*2402-B*4001 2.9 A*2402-B*4601 1.7 A*2402-B*5101 2.2 A*2402-B*5401 1 A*2402-B*5502 1 A*2901-B*0705 1 A*3001-B*1302 1.3 A*3303-B*5801 8 Cytokine Frequency (%) IL-2/-330 GG 7.2 IL-2/-330 GT 49.4 IL-2/-330 TT 43.4 IL-6/-174 CC 0 IL-6/-174 CG 0 IL-6/-174 GG 100 IL-10/-1082 AA 95.1 IL-10/-1082 AG 4.9 IL-10/-1082 GG 0 IL-10/-592 AA 45.7 IL-10/-592 AC 43.2 IL-10/-592 CC 11.1 IL-10/-819 CC 11.1 IL-10/-819 CT 43.2 IL-10/-819 TT 45.7 TNFalpha/-308 AA 1.2 TNFalpha/-308 AG 21.7 TNFalpha/-308 GG 77.1 TNFbeta/-252 AA 27.7 TNFbeta/-252 AG 42.2 TNFbeta/-252 GG 30.1

HLA-DPB1, -DQB1 and DRB1 Alleles in a Population from Slovakia I. Shawkatova Department of Immunology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic E-mail: [email protected] This population from Slovakia, Latitude 48N Longitude 17E consisted of 146 Caucasian individuals. The individuals were Human Immunology 65 (2004) © American Society for Histocompatibility and Immunogenetics, 2004 Published by Elsevier Inc.

drawn from an urban and rural environment and HLA alleles were determined using sequence specific primers. The results have previously been published in Tissue Antigens 51, 574, 1998. Only 30 individuals were typed for DRB1 and 143 for DQB1. Human Immunology 65, 1076 (2004). © American Society for Histocompatibility and Immunogenetics, 2004. Published by Elsevier Inc. HLA allele Gene frequency DPB1*0101 0.027 DPB1*0201 0.144 DPB1*0202 0.003 DPB1*0301 0.093 DPB1*0401 0.433 DPB1*0402 0.209 DPB1*0501 0.01 DPB1*0601 0.003 DPB1*0801 0 DPB1*0901 0.007 DPB1*1001 0.014 DPB1*1101 0.003 DPB1*1301 0 DPB1*1401 0.01 DPB1*1501 0.003 DPB1*1601 0.021 DPB1*1701 0.017 DPB1*1801 0 DPB1*1901 0 DQB1*0201 0.21 DQB1*0301 0.245 DQB1*0302 0.056 DQB1*0303 0.042 DQB1*0401 0.007 DQB1*0402 0.039 DQB1*0501 0.112 DQB1*0502 0.056 DQB1*0503 0.028 DQB1*0601 0.004 DQB1*0602 0.101 DQB1*0603 0.084 DQB1*0604 0.018 DRB1*01 0.731 DRB1*0103 0 DRB1*0301 0.096 DRB1*0302 0 DRB1*04 0.112 DRB1*07 0.142 DRB1*08 0.046 DRB1*09 0.004 DRB1*1001 0.023 DRB1*11 0.204 DRB1*12 0.015 DRB1*13 0.08 DRB1*1305 0 DRB1*1306 0 DRB1*14 0.027 DRB1*1410 0 DRB1*15 0.123 DRB1*16 0.054

0198-8859/04/$–see front matter