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Heidelberg, 1955. v+249 pp. 16 × 24.5 cm. Price 24 DM
Book Notices Prufung und Verarbeitung von Arzneidrogen. Erster Band: Chemische Priifung Allegemeine und spezielle Methoden. By Dr. FRITZGSTIRNER. Berlin/Gottingen/Heidelberg, Springer-Verlag, 1955. xi f 377 pp. 16 x 24.5 cm. Price D M 36, and Zweiter Band : Verarbeitung Allegemeine und spezielle Methoden. By Dr. FRITZGSTIRNER. Springer-Verlag, Berlin/Gottingen/Heidelberg, 1955. v 249 pp. 16 x 24.5 cm. Price 24 DM. The 6rst volume of this two-volume work is devoted to a presentation of general methods of analyses of botanical drugs and special methods applied t o a large number of drugs of vegetable origin. In the section on general methods are included those utilized in the assay of essential oils, the evaluation of bitter principles, the extraction and determination of tannins, and the estimation of the mineral contents of botanical drugs. These chapters are followed by others with discussions on the determination of the swelling qualities of drugs; the extraction of saponins by several methods, the evaluation of mucilaginous drugs, and the determination of water content in drugs. The special part includes methods of evaluation for many of the more widely used botanical drugs and several which in the United States would probably be considered obsolete. In the preparation of this book, the author has consulted all of the newer literature and has included in his treatise applications of many relatively new chromatographic and instrumental methods. The second volume is an extension of the first, and like it, is divided into a general and a special part. In the general part, methods of preparation and general methods of evaluation of galenical preparations such as extracts and tinctures are discussed. In the second part, methods of production and evaluation of extractive preparations are discussed. Both volumes are replete with literature references pertinent and significant t o the subjects discussed. The two volumes are provided with separate indexes, but this causes no inconvenience. The printing and binding are of good quality and the books can be recommended to anyone who is concerned with the development of methods of evaluation of botanical drugs and their preparations.
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Organic Syntheses. Vol. 35. T. L. CAIRNS,Editor. John Wiley and Sons, Inc.. New York, 1955. 122 pp. 15.5 x 23.5 cm. Price $3.75. vi Organic Syntheses, an annual publication of methods for the preparation of organic chemicals, now in its thirty-fifth year, is so well known to organic chemists and others who have occasion to need dependable preparative methods that its origin and background require no description. The format and style of the annual volumes change little from one year to the next and a uniform size has been maintained from the beginning. The first twenty-nine volumes have been issued in three
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collective volumes and this practice undoubtedly will be continued by the publisher. In Volume 35 methods of preparation are given for the following compounds: 1-acetylcyclohexanol; 2-amino-3-nitrotoluene; 3-benzyl-3methylpentanoic acid ; p-bromomandel$ acid; sec-butyl a-n-caproylpropionate ; n-butyl glyoxylate; 2-butyn-1-01; chloro-p-benzoquinine; N-chlorobetainyl chloride; cu-(4-chloropheny1)-y-phenylacetoacetonitrile; 1-(p-chlorophenyl-3-phenyl-2-propanone;2-chloropyrimidine; A'-cholesten-3,6-dione; A4-cholesten-3-one; cholesterol, As-cholesten-3-one, and A4-cholesten-3-one; diacetyl-d-tartaric anhydride; diethyl mercaptoacetal; diethylthiocarbamyl chloride; 2-( dimethylamino)pyrimidine; ethyl diethoxyacetate; ethyl isocyanide; ethyl N-phenylformimidate; 2-furfury1 mercaptan ; guanylthiourea; hexamethylbenzene ; o-methoxyphenylacetone ; 5-methylfurfuryldimethylatnine; 4-methyl-6-hydroxypyrimidine; 1-methyl-3-phenylindane; methyl 2-thienyl sulfide ; 8-methyl-6-valerolactone; trans-onitro-a-phenylcinnamic acid; 2-phenylcycloheptanone; 1-tetralone; thiobenzophenone; and p-toluenesulfenyl chloride. The book is provided with a cumulative subject index to Volumes 30 t o 35. inclusive. Oficial Methods of Analysis of the Associalion of OJkial Agricultural Chemists. 8th ed. WILLIAM HORWITZ, Editor. Association of Official Agricultural Chemists, Washington, 1955. xvi 1008 pp. 16 x 26 cm. Price $12. .domestic; $12.50 foreign. New and revised methods of analysis adopted by the Association of Official Agricultural Chemists since the publication of the 7th edition in 1950 are included in this new 8 t h edition, which has been expanded by approximately 100 pages. The expansion occurs chiefly in the fields of pesticides, flavoring extracts, drugs, extraneous materials, microchemical methods, and nutritional adjuncts, including vitamins. While nearly every section of the book has undergone some degree of revision, those of greatest interest to the readers of this Journal are in the section on drugs. I n this section one finds among the additions a thermal (melting point) method for determining the stereochemical composition of amphetamines, and directions for determining the optical-crystallographic properties of certain drugs. Reference tables of these properties are provided for antihistamines, barbiturates, sulfonamides, sympathomimetic arnines. and reineckates of quaternary ammonium compounds. A new section on hormones has been added t o the drug chapter, including methods of analysis for physiologically potent hormones heretofore determined mainly by bioassay. Instrumental methods and newer techniques such as chromotography have been utilized in the 8th edition of OJkiul Methods of Analysis. Thus a new chapter on spectrographic methods has been
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Organic Syntheses. Vol. 35. T. L. CAIRNS,Editor. John Wiley and Sons, Inc.. New York, 1955. 122 pp. 15.5 x 23.5 cm. Price $3.75. vi Organic Syntheses, an annual publication of methods for the preparation of organic chemicals, now in its thirty-fifth year, is so well known to organic chemists and others who have occasion to need dependable preparative methods that its origin and background require no description. The format and style of the annual volumes change little from one year to the next and a uniform size has been maintained from the beginning. The first twenty-nine volumes have been issued in three
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collective volumes and this practice undoubtedly will be continued by the publisher. In Volume 35 methods of preparation are given for the following compounds: 1-acetylcyclohexanol; 2-amino-3-nitrotoluene; 3-benzyl-3methylpentanoic acid ; p-bromomandel$ acid; sec-butyl a-n-caproylpropionate ; n-butyl glyoxylate; 2-butyn-1-01; chloro-p-benzoquinine; N-chlorobetainyl chloride; cu-(4-chloropheny1)-y-phenylacetoacetonitrile; 1-(p-chlorophenyl-3-phenyl-2-propanone;2-chloropyrimidine; A'-cholesten-3,6-dione; A4-cholesten-3-one; cholesterol, As-cholesten-3-one, and A4-cholesten-3-one; diacetyl-d-tartaric anhydride; diethyl mercaptoacetal; diethylthiocarbamyl chloride; 2-( dimethylamino)pyrimidine; ethyl diethoxyacetate; ethyl isocyanide; ethyl N-phenylformimidate; 2-furfury1 mercaptan ; guanylthiourea; hexamethylbenzene ; o-methoxyphenylacetone ; 5-methylfurfuryldimethylatnine; 4-methyl-6-hydroxypyrimidine; 1-methyl-3-phenylindane; methyl 2-thienyl sulfide ; 8-methyl-6-valerolactone; trans-onitro-a-phenylcinnamic acid; 2-phenylcycloheptanone; 1-tetralone; thiobenzophenone; and p-toluenesulfenyl chloride. The book is provided with a cumulative subject index to Volumes 30 t o 35. inclusive. Oficial Methods of Analysis of the Associalion of OJkial Agricultural Chemists. 8th ed. WILLIAM HORWITZ, Editor. Association of Official Agricultural Chemists, Washington, 1955. xvi 1008 pp. 16 x 26 cm. Price $12. .domestic; $12.50 foreign. New and revised methods of analysis adopted by the Association of Official Agricultural Chemists since the publication of the 7th edition in 1950 are included in this new 8 t h edition, which has been expanded by approximately 100 pages. The expansion occurs chiefly in the fields of pesticides, flavoring extracts, drugs, extraneous materials, microchemical methods, and nutritional adjuncts, including vitamins. While nearly every section of the book has undergone some degree of revision, those of greatest interest to the readers of this Journal are in the section on drugs. I n this section one finds among the additions a thermal (melting point) method for determining the stereochemical composition of amphetamines, and directions for determining the optical-crystallographic properties of certain drugs. Reference tables of these properties are provided for antihistamines, barbiturates, sulfonamides, sympathomimetic arnines. and reineckates of quaternary ammonium compounds. A new section on hormones has been added t o the drug chapter, including methods of analysis for physiologically potent hormones heretofore determined mainly by bioassay. Instrumental methods and newer techniques such as chromotography have been utilized in the 8th edition of OJkiul Methods of Analysis. Thus a new chapter on spectrographic methods has been
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