Title section, list of contents author and subject index

LIST O F C O N T E N T S VOLUME 24 (1994) Number 1 Peter J. Gebicke-Haerter, Andras Seregi, Angelika Schobert and Georg Hertting

The phorbol ester TPA potentiates Cholera toxin- and isoproterenolstimulated cyclic AMP-synthesis in primary astrocyte cultures

Martin Carli, Madhu B. Anand-Srivastava, Eduardo Molina-Holgado, Karen M. Dewar and Tomfis A. Reader

13

Effects of chronic lithium treatments on central dopaminergic receptor systems: G proteins as possible targets

Fumihiko Okada, Tamaki Horikawa, Yukiko Tokumitsu and Yasuyuki Nomura

23

Chronic desipramine treatment influences D~ stimulation and D, inhibition (dual control) ofadenylate cyclase by dopamine in rat striatum

G. T. Vatassery, W. E. Smith and H. T. Quach

29

Increased susceptibility to oxidation of vitamin E in mitochondrial fractions compared with synaptosomal fractions from rat brains

Shigeyuki Chaki, Ivlakoto Muramatsu and Susumu Otomo

37

Involvement of protein kinase C activation in regulation of acetylcholine release from rat hippocampal slices by minaprine

Sabine Kuchler, Marie-Noelle Graft, Serge Gobaille, Guy Vincendon, Annie-Claude Roche, Jean-Pierre Delaunoy, Michel Monsigny and Jean-Pierre Zanetta

43

Mannose dependent tightening of the rat ependymal cell barrier. In vivo and in vitro study using neoglycoproteins

Carola Eva, Mariella Fuseo, Rossella Brusa, Nicola Schiavo, Silvana Ricci Gamatero, Guido Vantini and Enrico Genazzani

57

Intracerebroventricular administration of nerve growth factor affects muscarinic cholinergic receptors in the cerebral cortex of neonatal rats

M. H. Meshki Baf, M. N. Subhash, K. Madepalli Lakshmana and B. S. Sridhara Rama Rao

67

Sodium valproate induced alterations in monoamine levels in different regions of the rat brain

Anita Garlind, Richard F. Cowburn and Christopher J. Fowler

73

Characterization of [~H]inositol 1,4,5-trisphosphate binding sites in human temporal cortical and cerebellar membranes

G. Bagetta, S. Nair, G. Nistico and J. O. Dolly

81

Hippocampal damage produced in rats by ct-dendrotoxin--a selective K + channel blocker--involves non-NMDA receptor activation

Maria Sylvia Viola, Georgina Rodriguez de Lores Arnaiz and Maria Amelia Enero

91

Na', K--ATPase activity in CNS and noradrenergic neurotransmission: time course of differential desipramine (DMI) effects

99

News Items

Number 2 Peter J. Morgan, Perry Barrett, H. Edward Howell and Rachel Helliwell

101

Invited Review: Melatonin receptors: localization, molecular pharmacology and physiological significance

David Sugden

147

Critique: Melatonin: binding site characteristics and biochemical and cellular responses iii

Index

iv

S. S. Lakhman and G. Kaur

159

Effect ofalloxan-induced diabetes on acetylcholinesterase activity from discrete areas of rat brain

Brian Pearce, Katherine Jakobson, Christine Morrow and Sean Murphy

165

Phosphatidic acid promotes phosphoinositide metabolism and DNA synthesis in cultured cortical astrocytes

R. M. Dawson

173

Rate constants of carbamylation and decarbamylation of acetylcholinesterase for physostigmine and carbaryl in the presence of an oxime

Jennifer K. Stewart, Todd G. Campbell, T. David Gbadebo, Nedathur Narasimhachari and and John W. Manning

183

Cardiovascular responses and central catecholamines in streptozocindiabetic rats

M. Morari, M. Menegale, G. Calo', L. Ferraro, C. Tomasini, C. Bianchi and L. Beani

191

Excitatory amino acids (EAAs) stimulate phosphatidylinositol turnover in adult rat striatal slices: interaction between NMDA and EAA metabotropic receptors Newsltems

Number 3 Akitane Mori, Jiankang Liu, Xiaoyan Wang and Motoko Kawai

201

Free radical scavenging by brain homogenate: implication to free radical damage and antioxidant defense in brain

R. Raulli, H. Alho and J. T. Wroblewski

209

N-methyl-D-aspartate receptor-induced translocation of protein kinase C to the nucleus in rat cerebellar slices

Rudi D'Hooge, Yin-Quan Pei, Bart Marescau and Peter P. De Deyn

215

Ontogenetic differences in convulsive action and cerebral uptake of uremic guanidino compounds in juvenile mice

Michel Noyer, Fran~oise de Laveleye, Georges Vauquelin, Jean Gobert and Ernst Wtilfert

221

Mivazerol, a novel compound with high specificity for e~_,adrenergic receptors: binding studies on different human and rat membrane preparations

K. Tsuiki, A. Takada, M. Grdiga and M. Diksic

231

Effect of hypothalamic 5,7-dihdroxytryptamine lesion on the anterograde transport ofserotonin as measured with labeled c~-methyl serotonin

Rosemarie Brett and Martin G. Rumsby

241

Susceptibility of myelin glycerophospholipids and sphingolipids to oxidative attack by hydroxyl free radicals as measured by the thiobarbituric acid test

Claudia Olenik, Angelika Uhl, Anja Thate and Dieter K. Meyer

253

Increase in cortical procholecystokinin gene expression induced by a meningo-cortical injury: studies on the involvement of the "immediate early gene" c-fos

Hiroaki Nishio, Yuuji Negishi, Atsuko Inoue and Yoshihiro Nakata

259

Differential effects of divalent cations on specific ~H~3R 65630 binding to 5-HT~ receptors in rat cortical membranes

Miguel Alfonso, Rafael Duran, Carlos B. Duarte, lldete L. Ferreira and Ars61io P. Carvalho

267

Domoic acid induced release of [~H]GABA in cultured chick retina cells

Jolanta B. Zawilska and Jerzy A. Nowak

275

Dopamine receptor regulating serotonin N-acetyltransferase activity in chick retina represents a D~-like subtype: pharmacological characterization

Index

v

Jiirgen L6ffler, Dominique Langui, Alphonse Probst and Gerda Hnber

281

Accumulation of a 50 kDa N-terminal fragment of fl-APP695 in Alzheimer's disease hippocampus and neocortex

Sukanya Chaudhury, Sumantra Das, Sudhir K. Banerjee and Pranab K. Sarkar

289

Identification and characterization of a tubulin binding protein in rat brain plasma membrane

i

News Items

Number 4 L. Patthy and K. Nikolics

301

Invited Review: Agrin-like proteins of the neuromuscular junction

Urszula Wysmyk, Simo S. Oja, Pirjo Saransaari and Jan Albrecht

317

Long-term treatment with ammonia affects the content and release of taurine in cultured cerebellar astrocytes and granule neurons

S. Cossy-Isasi and P. Panzetta

323

In vitro changes of ganglioside immunostain localization in developing

neural cells Mats P. Sandberg, Anna-Lena Ask and Christopher J. Fowler

329

Characterization of [3H]CGS 19755 binding sites in the rat spinal cord

Da Han, Kiyokazu Ogita, Kosumi Kashiwai, Sachiko Narita and Yukio Yoneda

339

Binding of [3H]triamcinolone acetonide to glucocorticoid receptors in brain cytosol fractions of rats with intact adrenals

Erwin Tareilus, Juergen Schoch and Heinz Breer

349

GABAB-receptor-mediated inhibition of calcium signals in isolated nerve terminals

Patricia Salazar, Teresa Montiel, Sim6n Brailowsky and Ricardo Tapia

363

Decrease of glutamate decarboxylase activity after in vivo cortical infusion of T-aminobutyric acid

Margaret dos Santos Medeiros and Anthony J. Turner

369

Comparison of cholecystokinin metabolism by membrane preparations from the human astrocytoma clone D384 and the neuroblastoma line SH-SY5Y

Kiyokazu Ogita, Tsuyoshi Sakamoto, Da Han, Yasutaka Azuma and Yukio Yoneda

379

Discimination by added ions of ligands at ionotropic excitatory amino acid receptors insensitive to N-methyl-D-aspartate in rat brain using membrane binding techniques

Tsuneichi Hashimoto, He Shu and Kinya Kuriyama

389

Muscarinic M, receptor mediated inhibition of GABA release from rat cerebral cortex

Chantal Cazevieille, Agnes Muller, Frangoise Meynier, Nathalie Dutrait and Claude Bonne

395

Protection by prostaglandins from glutamate toxicity in cortical neurons

399

Book Reviews

i

News Items

Number 5 Christopher J. Fowler and Graeme L. Fraser

401

Invited Review: It-, 8-, ~:-Opioid receptors and their subtypes. A critical review with emphasis on radioligand binding experiments

John R. Traynor

427

Critique: Opioid receptors and their subtypes: focus on peripheral isolated tissue preparations

Index

vi Anton N. M. Schoffelmeer and Arie H. Mulder

433

Critique: Functional studies on opioid receptor heterogeneity in the central nervous system

Darryle D. Schoepp

439

Commentary: Novel functions for subtypes of metabotropic glutamate receptors

T. E. Salt and S. A. Eaton

451

The function ofmetabotropic excitatory amino acid receptors in synaptic transmission in the thalamus: studies with novel phenylglycine antagonists

Norbet K6nig, Philippe Serrano and Marie-Jeanne Drian

459

AMPA elicits long-lasting, partly hypothermia-sensitive calcium responses in acutely dissociated or cultured embryonic brainstem cells

U. Sormewald, T. B. Mfiller, N. Westergaard, G. Unsg~d, S. B. Petersen and A. Schousboe

473

NMR spectroscopic study of cell cultures of astrocytes and neurons exposed to hypoxia: compartmentation of astrocyte metabolism

Pascal Froissard and Dominique Duval

485

Cytotoxic effects of glutamic acid on PC 12 cells

Dusica Maysinger, Pedro Piccardo, Paolo Liberini, Ivan Jalsenjak and A. Claudio Cuello

495

Encapsulated genetically engineered fibroblasts: release of nerve growth factor and effects in vivo on recovery of cholinergic markers after devascularizing cortical lesions

505

Book Review

i

News Items

Number 6 Bjarke Ebert, Ulf Madsen, Trine M. Lund, Sibylle M. Lenz and Povl Krogsgaard-Larsen

507

Molecular pharmacology of the AMPA agonist (S)-2-amino-3-(3hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA

Susana T. Wofchuk and Richard Rodnight

517

Glutamate stimulates the phosphorylation of glial fibrillary acidic protein in slices of immature rat hippocampus via a metabotropic receptor

Grazia Lombardi, Domenico E. Pellegrini-Giampietro, Patrizia Leonardi, Giovanna Cherici, Roberto Pellicciari and Flavio Moroni

525

The depolarization-induced outflow of D-[3H] aspartate from rat brain slices is modulated by metabotropic glutamate receptors

Nadia Gabellini, Radmila M. Manev and Hari Manev

533

Is the heterologous expression of metabotropic glutamate receptors (mGluRs) an appropriate method to study the mGluR function? Experience with human embryonic kidney 293 cells transfected with mGluR 1

Masashi Katsura, Seitaro Ohkuma, Da-Zhi Chen and Kinya Kuriyama

541

Ethanol-induced alteration in activities of cerebral phosphatidylinositol 4,5-biphosphate-specific and cytosolic phospholipase C in the brain: analysis using NG 108-15 cells and brains from ethanol-inhaled mice

A. Contestabile, F. Facchinetti, E. Ciani, M. Sparapani and M. Virgili

549

Chronic neonatal blockade of NMDA receptor does not affect developmental polyamine metabolism but results in altered response to the excitotoxic induction of ornithine decarboxylase

J. Bajgar, J. Fusek and F. Skopec

555

Changes of cholinesterases in the blood and some tissues following administration of tacrin and its two derivatives to rats

Index

vii

Tiziana Guamieri, Marco Virgili, Silvia Carraro and Luigi Villani

559

Quinolinic acid but not MK-801 protects the dopaminergic system from 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine-induced toxicity in goldfish retina

Stephanie Wengert Watts, Susan L. Gackenheimer, Donald R. Gehlert and Marlene L. Cohen

565

Autoradiographic comparison of [t:q]LSD-labeled 5-HT.,A receptor distribution in rat and guinea pig brain

R. Janhky, V. Varga, S. S. Oja and P. Saransaari

575

Release of [3H]GABA evoked by glutamate agonists from hippocampal slices: effects of dithiothreitol and glutathione

Ann D. Mitrovic and Graham A. R. Johnston

583

Regional differences in the inhibition of L-glutamate and L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylate, threo-3-hydroxy-Daspartate and D-aspartate

Jian Kai Liu and Takeshi Kato

589

Effect of physostigmine on relative acetylcholine output induced by systemic treatment with scopolamine in in vivo microdialysis of rat frontal cortex

597

Book Review

i

News Items

AUTHOR INDEX Albrecht J., 317 Alfonso M., 267 Alho H., 209 Anand-Srivastava M. B., 13 Ask A-L., 329 Azuma Y., 379 Bagetta G., 81 Bajgar J., 555 Banerjee S. K., 289 Barrett P., 101 Beani L., 191 Bianchi C., 191 Botme C., 395 Brailowsky S., 363 Breer H., 349 Brett R., 241 Brusa R., 57 Cal6 G., 191 Campbell T. G., 183 Carli M., 13 Carraro S., 559 Carvalho A. P., 267 Cazevieille C., 395 Chald S., 37 Chandhury S., 289 Chen D-Z., 541 Cherici G., 525 Ciani E., 549 Cohen M. L. 565 Contestabile A., 549 Cossy-Isasi S., 323 Cowburn R. F., 73 Cuello A. C., 495

Eaton S. A., 451 Ebert B., 507 Enero M. A., 91 Eva C., 57

Kuchler S., 43 Kuriyama K., 389, 541

Facchinetti F., 549 Ferraro L., 191 Ferreira I. L., 267 Fowler C. J., 73, 329,401 Fraser G. L., 401 Froissard P., 485 Fuseo M., 57 Fusek J., 555 Gabeilini N., 533 Gackenheimer S. L., 565 Garlind A., 73 Gbadebo T. D., 183 Gebicke-Haerter P. J., 1 Gehlert D. R., 565 Genazzani E., 57 Gobaille S., 43 Gobert J., 221 Graft M-N., 43 Grdi~a M., 231 Guarnieri T., 559 Han D., 339, 379 Hashimoto T., 389 Helliwell R , 101 HerRing G., 1 Horikawa T., 23 Howell H. E., 1Ol Huber G., 281 Inoue A., 259

D'Hooge R., 215 Das S., 289 Dawson R. M., 173 De Laveleye F., 221 De Deyn P. P., 215 Delaunoy J-P. 43 Dewar K. M., 13 Diksic M., 231 Dolly J. O., 81 Drian M-J., 459 Doarte C. B., 267 Duran R., 267 Dutrait N., 395 Duval D., 485

Jakobson K., 165 Jalsenjak I., 495 Jafiaky R., 575 Jiankang Liu, 201 Johnston G. A. R., 583 Kashiwai K., 339 Kato T., 589 Katsura M., 541 Kaur G., 159 Kawai M., 201 K6nig N., 459 Krogsgaard-Larsen P., 507

ix

Lakhman S. S., 159 Langui D., 281 Lenz S. M., 507 Leonardi P., 525 Liberini P., 495 Liu J. K., 589 LOftier J., 281 Lombardi G., 525 Lund T. M., 507 Madepaili Lakshmana K., 67 Madsen U., 507 Manev H., 533 Manev R. M., 533 Manning J. W., 183 Marescau B., 215 Maysinger D., 495 Menegale M., 191 Meshki Bar M. H., 67 Meyer D. K., 253 Meynier F., 395 Mitrovic A. D., 583 Molina-Holgado E., 13 Monsigny M., 43 Montiel T., 363 Morari M., 191 Morgan P. J., 101 Mori A., 201 Moroni F., 525 Morrow C., 165 Mulder A. H., 433 Muller A., 395 MOiler T. B., 473 Muramatsu M., 37 Murphy S., 165 Nair S., 81 Nakata Y., 259 Narasimhachari N., 183 Narita S., 339 Negishi Y., 259 Nikolics K., 301 Nishio H., 259 Nistico G., 81 Nomura Y., 23 Nowak J. A., 275 Noyer M., 221

Index Ogita K., 339,379 Ohkuma S., 541 Oja S. S., 317,575 Okada F., 23 O|enik C., 253 Otomo S., 37 Panzetta P., 323 Patthy L., 301 Pearce B., 165 P¢i Y-Q., 215 Pellegrini-Giampietro D. E., 525 Pellicciari R., 525 Petersen S. B., 473 Piccardo P., 495 Probst A., 281 Quach H. T., 29 Raulli R., 209 Reader T. A., 13 Ricci Gamalero S., 57 Roche A-C., 43 Rodnight R., 517 Rodriguez de Lores Arnaiz G., 91 Rumsby M. G., 241 Sakamoto T., 379 Salazar P., 363

Salt T. E., 451 Sandberg M. P., 329 dos Santos Medeiros M., 369 Saransaari P., 317, 575 Sarkar P. K., 289 Schiavo N., 57 Schobert A., 1 Schoch J., 349 Schoepp D. D., 439 Schoffelmeer A. N. M., 433 Schousboe A., 473 Seregi A., 1 Serrano E, 459 Shu H., 389 Skopcc F., 555 Smith W. E., 29 Sonnewald U., 473 Sparapani M., 549 Sridhara Rama Rao B. S., 67 Stewart J. K., 183 Subhash M. N., 67 Sugden D., 147

Traynor J. R., 427 Tsuiki K., 231 Turner A. J., 369

Takada A., 231 Tapia R., 363 Tareilus E., 349 Thate A., 253 Tokumitsu Y., 23 Tomasini C., 191

Xiaoyang Wang, 201

Uhl A., 253 Unsg~rd G., 473 Vantini G., 57 Varga V., 575 Vatassery G. T., 29 Vauquelin G., 221 Villani L., 559 Vincendon G., 43 Viola M. S., 91 Virgili M., 549, 559 Wcngert Watts S., 565 Westergaard N., 473 Wofchuk S. T., 517 Wroblewski J. T., 209 WUlfert E., 221 Wysmyk U., 317

Yoneda Y., 339, 379 Zanctta J-P.,43 Zawilska J. B., 275

SUBJECT INDEX

acetylcholine release - caused by eserine, 589 influence of minaprine, 37 involvement of protein kinase C, 37 acetylcholine - mierodialysis, 589 acetylcholinesterase activity - effect of diabetes, 159 acetylcholinesterase - carbamylation and decarbarmylation, 173 - effect o f physostigmine and carbaryl, 1 influence of oxime, 173 adenylate cyclase - action of G T P and dopamine, 23 agrin-like proteins - o f neuromuscular junction, 301 alloxan - induced diabetes, 159 A~ receptors - binding o f mivazerol, 221 zheimer' s disease - accumulation of ~-amyloid precursor protein69s, 281 y-aminobutyric acid - see G A B A ct-amino-hydroxy-5-methyl-4-isoxazole-propionic acid - see AMPA a m m o n i a - affects taurine release, 317 AMPA agonist - (S)-APPA, 507 AMPA agonists - molecular pharmacology, 507 AMPA antagonist - (R)-APPA, 507 AMPA receptors - activated by ot-dendrotoxin, 81 AMPA effect on calcium, 459 I~-amyloid precursor p r o t e i n . . - accumulation in Alzheimer's disease, 281 - 50 k D a l ~ e r m i n a l fragment, 281 anterograde serotonin transport, 231 antioxidant - defense in brain, 201 (S)-APPA - A M P A agonist, 507 tR)-APPA - A P M A antagonist, 507 H-aspartate release - modulated by metabotropic glutamate receptors, 525 aspartate - uptake into synaptosomes, 583 astrocytes - content and release of taurine, 317 - D N A metabolism, 165 - glucose metabolism, 473 - hypoxia, 473 - phosphoinositide metabolism, 165 stimulation of cAMP, 1 astrocytoma clone D384 cell line - eholecystokinin metabolism, 369 autoradiography - localisation o f I~I-LDS binding sites, 565 -

-

-

-

-

binding experiments - for localising opioid receptors, 401 binding sites - for iodomelatonin, 101 calcium responses - to AMPA, 459 calcium signals - related to activation o f G A B A a receptor, 349 calcium - influences binding of liggnds to n o n - N M D A amino acid receptors, 379 c A M P - influence of Cholera toxin, isoproterenol, phorbol ester, 1 carbamylation - of acetylcholinesterase, 173 carbaryl - effect upon acetylcholinesterase, 173 cardiovascular responses - in diabetic rats, 183 catecholamines - in diabetic rats, 183 3H-CGS 19755 binding sites - to spinal cord, 329 3H-CGS 19755 - ligand for N M D A receptor, 329 cholecystokinin metabolism - in different cell lines, 369 Cholera toxin - action on cAMP, 1 cholinergic markers - influence of nerve growth factor, 459 cholinesterases - effect o f taerin and derivatives, 555 - in blood, 555 convulsant uremic guanidino compounds, 215 cytotoxic effects - o f glutamate, 485 c-fos - activation associated with expression of procholecystokinin gene, 253 c-jun - activation associated with expression o f procholecystokinin gene, 253

xi

xii

Subject Index

decarbarmylation - o f aeetylcholinesterase, 173 ct-dendrotoxin - and non-NMDA activation, 81 - induces hippoeampal damage, 81 selective K ÷ channel blocker, 81 desipramine treatment - dopamine action on adenylate cyclase, 23 influence on dopamine receptors, 23 desipramine - action on D. and D. receptors, 23 effect upon Na +, k+-ATI/ase, 91 development o f neurones - loealisation o f gangliosidcs, 323 diabetes - effect upon acetylcholinesterase activity, 159 - produced by alloxan, 159 diabetic rats - cardiovascular responses and catecholamines, 183 streptozocin, 183 5,7-dihydoxytryptamine lesion - anterograde serotonin transport, 231 dithiothreitol - influence on glutamate-induced ielease o f GABA, 575 divalent cations - effects on "I-I-GR 65630 binding to 5-HT 3 receptors, 259 DNA synthesis - in astrocytes, 165 DNA synthesis - promoted by phosphatidie acid, 165 domoic acid - induces release o f GABA from retinal cells, 267 dopamine D 4 receptors - regulates activity o f serotonin N-acetylWansferase, 275 dopamine receptor - regulates serotonin N-acetyl transferase activity in retina, 275 dopamine receptors - effect o f chronic lithium treatment, 13 influence o f desipramine, 23 dopamine - influence on adenylate eyclase, 23 dopaminergic system - toxicity induced by MPTP, 559 -

-

-

-

encapsulated fibroblasts, 495 ependymal cell junctions - neoglycoproteins, 43 eserine - releases acetyleholine, 589 ethanol - effect on phosphaddylinositol-4,5-bisphosphate, 541 effect on phospholipase C, 541 excitatory amino acids - influence on phosphatidylinositol turnover, 191 excitotoxic induction - o f ornithine decarboxylase, 549 -

fibroblasts - genetically engineered, 495 production o f nerve growth factor, 495 free radical damage - in brain, 201 -

GABA infusion - effect upon glutamate decarboxylase activity, 363 3H-GABA release - evoked by glutamate agonists, 575 from retinal cells induced by domoic acid, 267 GABA release - glutathione, dithiothreitol influence on glutamate action, 575 - mediated by musearinic M I receptors in cortex, 389 GABAB-reeeptor-mediated inhibition o f calcium signals, 349 ganglioside immunostaln localisation - developmental changes, 323 glial fibrillary acid protein - phosphorylation induced by glutamate, 517 glucocorticoid receptors in rat brain - characteristics, 339 glucocorticoid receptors - binding o f 3H-triamcinolone acetonide, 339 glucose metabolism - in astrocytes, 473 glutamate action - influence o f glutathione, dithiothreitol, 575 glutamate agonists - evoke release o f 3H-GABA, 575 glutamate decarboxylase activity - influence o f GABA infusion, 363 glutamate receptor agonists - influence on PC12 cells, 485 glutamate receptors - metabotropic subtypes, 439 glutamate toxicity - protection by prostaglandins, 395 glutamate - cytotoxic effects, 485 - effect on glial fibrillary acid protein, 517 uptake into synaptosomes, 583 glutathione - influence on glutamate-induced release o f GABA, 575 ~Hlycerophospholipids - susceptibility to oxidative attack, 241 -GR 65630 binding - to 5-.HT3 receptor, 259 granule neurones - content and release o f marine, 317 GTP - influence on adenylate cyclase, 23 guanidinosuccinate - convulsant, 215 G-protein coupled glutamate receptors, 439 G-protein - target for lithium, 13 -

-

hippocampal damage - caused,by tx-dendrotoxin, 81 5-HT2• receptors - labeled by '~I-LSD, 565 - localisation in guinea pig and rat brains, 565

Subject Index

5-HT. receptors - 3H-GR 65630 binding, 259 3 5-HT~3 receptors - effects o f divalent cations on H - G R 65630 binding, 259 hydroxyl free radicals - attack on myelin lipids, 241 hypothermia-sensitive calcium responses - in bralnstem cells, 459 hypoxia - astrocytes, 473 changes followed by NMR, 473 3H-inositol 1,4,5-triphophosphate binding - characterisation, 73 125I-iodomelatonin - binding, 147 -

ionotropic excitatory amino acid receptors - binding studies, 379 isoproterenol - stimulates cAMP, 1 kidney cells - transfected with metabotropic glutamate receptor eDNA, 533 lithium treatment - influence on G-protein, 13 lithium - effect on dopaminergic receptor, 13 125I-LSD - labels 5-I-I[F2A receptors, 565 - localisation of 5mding sites, 565 mannose - effect on ependymal cell barrier, 43 melatonin receptors, 101,147 melatonin - molecular and cellular effects, 117 meningo-cortical injury - affects e-fos, c-jun and procholecystokinin gene, 253 metabotropic excitatory amino acid receptors - in transmission, 451 metabotropic glutamate receptor e D N A - used to transfect kidney cells, 533 metabotropic glutamate receptors, 439 - heterogeneity, 533 novel functions, 439 metabotropic receptors, 191 - activation causes GFAP phosphorylation, 517 involved in aspartate release, 525 s - m e t h y l serotonin - used to measure serotonin transport, 231 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine - see MPTP methylguanidine - convulsant, 215 microdialysis - o f acetylcholine, 589 minaprine - influence on acetylcholine release, 37 mitochondrial m e m b r a n e s - oxidation of vitarnine E, 29 mivazerol - specificity for (~.:receptors, 221 MK-801 - does not protect a-galnst M P T P toxicity, 559 modulation o f aspartate release - by glutamate receptors, 525 monoamines - effect of sodium valproate, 67 MPTP-induced toxicity - of retinal dopamine system, 559 protection by quinolinic acid, 559 muscarinic M~ receptors - mediates inhibition o f G A B A release in cortex, 389 muscarinic receptors - influence of nerve growth factor, 57 myelin lipids - susceptibile to oxidative attack, 241 -

-

-

Na +, K+-ATPase actvity - effect of desipramine, 91 Na+,K+-ATPase activity - associated with noradrcnergic system, 91 neoglycoproteins - and ependymal cell junctions, 43 nerve growth factor - effect on muscarinic receptors, 57 influence on cholinergic parameters, 459 - produced in flbroblasts, 495 neuroblastoma line SH-SY5Y - eholecystokinin metabolism, 369 neuromuscular junction - agrin-like proteins, 301 N M D A receptor blockade - effect on polyamine metabolism, 549 N M D A receptor - induces translocation of PKC, 209 -3H-CGS 19755 a ligand, 329 - binding studies, 379 N M D A receptor activation - translocation of P K C into nucleus, 209 N M D A - action on phosphatidylinositol turnover, 191 N M R - to follow changes from hypoxia, 473 n o n - N M D A receptors - binding of ligands affected by calcium and potassium thiocyanate, 379 noradrenergic system - involvement o f Na +, K+-ATPase activity, 91 nuclear magnetic resonance - see N M R nucleus - PKC, 209 N-methyl-D-aspartate - see N M D A -

xiii

xiv

Subject Index

opioid receptors - heterogeneity, 433 - in peripheral tissues, 427 - subtypes, 401 ornithine decarboxylase - excitotoxic induction, 549 oxidation - o f vitamine E, 29 oxime - action o f acetylcholinesterase, 173 PC12 cells - influence of glutamate receptor agonists, 485 ~Hhenylglycine antagonists - at metabotropic glutamate receptors, 451 -phorbol ester binding - 209 phorbol ester - potentiates Cholera toxin stimulated cAMP, 1 potentiates isoproterenol stimulated cAMP, 1 phosphatidic acid - promotes D N A synthesis, 165 promotes phosphoinositide metabolism, 165 phosphatidylinositol turnover - effect o f excitatory amino acids, 191 phosphatidylinositol-4,5-bisphosphate - influence o f ethanol, 541 phosphoinositide metabolism - in astrocytes, 165 promoted by phosphatidic acid, 165 phospholipase C - influence o f ethanol, 5,11 phosphorylation - o f GFAP by glutamate, 517 physostigrnine - effect upon acetylcholinesterase, 173 P K C translocation - caused by activation o f N M D A receptor, 209 polyamine metabolism - action o f N M D A receptors, 549 potassium channel blocker - ct-dendrotoxin, 81 potassium thiocyanate - influences binding o f ligands to n o n - N M D A amino acid receptors, 379 procholecystokinin gene - induced by injury, 253 prostaglandins - protects neurones from glutamate toxicity, 395 protein kinase C - in release o f acetylcholine, 37 protein kinase C - see P K C -

-

-

quinolinic acid - protects MPTP-induced toxicity o f dopaminergic system, 559 receptors- for melatonin, 101,147 release - o f G A B A , 389 retina of goldfish - MPTP-induced toxicity o f dopamine system, 559 retinal cells - release o f G A B A , 267 retinal seromnin N-acetyltransferase, 275 scopolamine - influence on eserine-induced release o f aeetylcholine, 589 serotonin N-acetyltransferase in retina - regulated by dopamine via D4-receptor, 275 serotonin transport - effect o f lesions by 5,7-dihydroxytryptamine, 231 - measured with ct-methyl-serotonin, 231 serotonin - see 5-HT, 5-hydroxytryptamine sodium, potassium ATPase - see Na +, K+-ATPase sodium valproate - action on monoamines, 67 sphingolipids - susceptibility to oxidative attack, 241 spinal cord - N M D A receptors, 329 sta'eptozocin - diabetic rats, 183 synaptosomes - oxidation o f vitamine E, 29 uptake o f glutamate and aspartate, 583 -

tacrin - effect upon cholinesterases, 555 taurine - release influenced by ammonia, 317 thiobarbituric test - measurement o f oxidative attack on myelin lipids, 241 transfection - o f kidney cells with e D N A o f glutamate receptor, 533 3H-triamcinolone acetonide binding - to glucocorticoid receptors, 339 tubulin binding protein - in plasma membrane, 289 uremic guanidino compunds - uptake in juvenile mice, 215 vitamine E - an antioxidant in mitochondrial membranes, 29 oxidation, 29 -