Academy of Pharmaceutical Sciences

Academy of Pharmaceutical Sciences President-Harry B. Kostenbauder President-elect--Chester J. Cavallito Vice president-Gllbert S. Banker Past president-Thomas J. Macek Executive secretary-William C. Roemer

BUSINESS SESSION

Wednesday, April 26, 1:30 p.m.-Room 111, Astrohall

Wednesday, April 26, 12:00 ,noon-Room 111, Astrohall

Call to order Reading of communications President's report-Harry B. Kostenbauder Executive secretary's report-William C. Roemer Committee reports 1. Committee for organizational affairs-Roy Kuramoto 2. Committee for professional and public affairs-David E. Guttman 3. Committee for scientific affairs-Edward E. Smissman F. New business G. Adjournment

Luncheon Speaker-Chester J. CavaHito

EXECUTIVE COMMITTEE

EXECUTIVE COMMITTEE

Sunday, April 23, 10:00 a.m.-Holiday A, Holiday Inn LUNCHEON

(Tickets sold at APhA Registration Desk, Astrohall, and Academy Office, Room 101-103, Astrohall)

A. B. C. D. E.

Wednesday, April 26, 3:00 p.m.-Room 210, Astrohall

Academy Sections Basic Pharmaceutics Chairman-William I. Higuchi Chairman-eiect-George Zografi Vice chairman-James T. Dolulsio Secretary-Arthur R. Mlodozenlec

FIRST SESSION-DISSOLUTION AND SOLUBILITY

Monday, April 24, 9:00 a.m.-Room 100, Astrohall Presiding-Richard Lindstrom and John Lach 9:00 a.m.-I. Dissolution and Phase Diagram Studies on Griseofulvin·Succinic Acid Solid Dispersions-W.L. Chiou and S. Niazi 9:15 a.m.-2. Caffeine Complexes With Low Water Solubility. Syn· thesis and Dissolution Rates of 1:1 and 1:2 Caffeine·Gentisic Acid Complexes-T. Higuchi and I.H. Pitman 9:30 a.m.-3. Solvate Formation and Fast Dissolving Drug Species. Chloral Hydrate, Trichloroethanol and Other Adducts of Ampi· cillin-T. Higuchi, K. Uekama, M. Nakano and C. Huang 9:45 a.m.-4. The Programmed Release Rate of Drug From a Co· solvent System Using Complexation-T. Higuchi, K. Ashida and F. Theeuwes 10:00 a.m.-5. Complexing and Solubility Properties of Tetracycline Antibiotics With Calcium and Magnesium 10ns~P.W. Stern and W.I. Higuchi 10:15 a.m.-6. A Study of the Physical·Chemical Properties of Some Substituted Amides in Aqueous Solution and an Evaluation of Their Potential Use as Solubilizing Agents-P. DeLuca, L. Lachman and H. Schroeder 10:30 a.m.-7. Solubility of Normal and Branched Alkyl Barbiturates in Normal Alkanols-H. Petersen Jr" K. Alexander, A. Paruta, B. Laprade and J. Manger 10:45 a.m.-8. Solvent Effects on the Dissolution of Pharmaceutical Solvates-H.L. Fung and T. Nealon 11:00 a.m.-9. Observations on the Solubility of Organic Hydrochlorides-S.F. Kramer and G.L. Flynn 11:15 a.m.-IO. The Solubility Behavior of Cholesterol in Model Bile Systems-D. Mufson, L.J. Ravin, K. Meksuwan and J. Zarembo 11:30 a.m.-H. A "Versatile" In Vitro Dissolution Test ApparatusA.C. Shah and C.B. Peot SECOND SESSIO~-PHARMACOKINETIC MODEI-S

Monday, April 24, 1:30 p.m.-Room 100, Astrohall Presiding-Arlyn Kinkel and Carl Metzler 1:30 p.m.-12. An Analog Computer Program for Simulating Multi· variable Dosing Regimens-L. Kirschner, T.H. Simon and C.E. Rasmussen 1:45 p.m.-l3. Drug Elimination and Apparent Volume of Distribution in Multicompartment Systems-D. Perrier and M. Gibaldi

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Journal of the AMERICAN PHARMACEUTICAL ASSOCIATION

2:00 p.m.-I4. Properties of the Michaelis·Menten Equation and Its Integrated Form Which Are Useful in Pharmacokinetics-J.G. Wagner 2:15 p.m.-I5. Quantitation of Both Rate of Gastrointestinal Absorption and Rate of Renal Reabsorption of Acidic and Basic Drugs Based on Extraction Theory-J.G. Wagner and A.J. Sed man 2:30 p.m.-I6. Quantitative Pooling of Both Parallel Michaelis·Men· ten Metabolite Formation Equationsand Langmuir·Type Equations for Binding of Drugs to Tissues-A.J. Sedman and J.G. Wagner 2:45 p.m.-17. The Mathematical Basis for Design and Analysis of Pharmacokinetic Studies-C.M. Metzler and G.L. Elfring 3:00 p.m.-lB. A Mathematical Evaluation of Some Commonly Used Pharmacokinetic Models-C.M. Metzler arid G.L. Elfring 3:15 p.m.-19. Additional Analysis of the Human Buccal Absorption of Drugs by the Physical Model Approach-K.R.M. Vora, W.I. Higuchi and N.F.H. Ho 3:30 p.m.-20. Transport of Alkyl Homologues Across Synthetic and Biological Membranes-A N~w Model for Chain Length·Activity Relationships-S.H. Yalkowsky and G.L. Flynn 3:45 p.m.-21. A Two Phase Series Model For the Transport of Ste· roids Across the Fully Hydrated Stratum Corneum-To Yotsuyanagi and W.I. Higuchi . THIRD SESSION-BUSINESS

Monday, April 24, 4:00 p.m.-Room 100, Astrohall FOURTH SESSION-MECHANISMS OF DRUG DEGRADATION

Tuesday, April 25, 8:45 a.m.-Room 100, Astrohall Presiding-Tom Oesterling and J. T. Carstensen 8:45 a.m.-22. Decomposition of Benzoic Acid Derivatives in the Solid State-J. Carstensen and M. Musa 9:00 a.ni.-23. Kinetics and Mechanism of Hydrolysis of 2-Arylcar· boxy·tetrahydropyrans. I. The Hydrolysis of Tetrahydropyran2'01 Benzoate-A. Hussain, M. Yamazaki and J. Truelove 9:15 a.m.-24. Aqueous Degradation of Bakers Antifol (4-[p·(4,6Diamino-I,2-dihydro-2,2-dimethyl-s·triazine -1- yl)hydrocin namido]o·toluenesulfonyl Fluoride)-J~Y. Wang and A.P. Simonelli 9:30 a.m.-25. The Hydrolytic Behav.ior of Some N·Acyl Phthalimides -V. Stella and T. Higuchi 9:45 a.m.-26. Pro·Drugs of Hexachlorophene. The Synthesis and Rates of Hydrolysis of Esters of Hexachlorophene-H. Takechi, T. Higuchi and I.H. Pitman 10:00 a.m.-27. Arabinosylcytosine Stability in Aqueous Solutions: pH Profile and Shelf· Life Predictions-R.E. Notari, M.L. Chin and R. Wittebort 10:15 a.m.-2B. Solvolyses of Cytosine and Cytidine-E.R. Garrett andJ. Tsau 10:30 a.m.-29. The Alkali Catalyzed Hydrolysis of 5-Halodeoxy· uridines-E.R. Garrett, C;M. Won and H. Nestler

10:45 a.m.-30. The Ortho Effect in the Alkaline Hydrolysis of Ortho-

11:00 a.m.-57. Effect of Drug-Polymer Ratio on the Absorption of

Substituted Benzoylcholine Esters-J.J. Zimmerman and S.J. Yau 11:00 a.m.-31. Kinetics of Solvolysis of 1-(4-Chlorobenzoyl)-3-(5Tetrazolylmethyl) Indole (BL-R743-lntrazole)-V.K. Prasad, R.A. Ricci and A.P. Granatek 11:15 a.m •.:......32. Solvolysis of Basically Su bstituted Dibenzocycloheptanes-H.V. Maulding, D. Brusco, J. Polesuk and A. Michaelis 11:30 a.m.-33. Investigations of the Hydrolytic Products of a Disubstituted Barbituric Acid-H.V. Maulding, J. Nazareno, J. Polesuk and A. Michaelis 11:45 a.m.-Student paper

Reserpine From Polyvinylpyrrolidone (PVP) Coprecipitates-E.I. Stupak and T.R. Bates 11:15 a.m.-58. Kinetics of Heparin Removal From the Circulation of the Miniature Swine-P.A. Harris and K.L. Harris 11:30 a.m.-59. Effects of Various Vasoactive Substances on the Subcutaneous Absorption Kinetics of Local Anesthetics-I.H. Patel and R.H. Levy SEVENTH SESSION-PHARMACOKINETICS IN MAN

Wednesday, April 26, ·3 :00 p.m.-Room 100, Astrohall FIFTH SESSION-CHEMICAL EQUILIBRIUM

Presiding-Stuart Eriksen and Malcolm Rowland

Tuesday, April 25, 1:30 p.m.-Room 100, Astrohall

3:00 p.m.-60. Comparison of Ampicillin and Hetacillin Pharmaco-

Presiding-Anthony Simonelli and Anwar Hussain

3:15 p.m.-61. Effect of Bed Rest on the Bioavailability of Tetra-

1:30 p.m.-34. Potentiometric Determination of Overlapping Dis-

3:30 p.m.-62. Pharmacokinetics of Pentobarbital After Intravenous

sociation Constants-P.J. Niebergall, R.L. Schnaare and E.T. Sugita 1:45 p.m.-35. The Interaction of p-Acetaminophen With Some Methylated Xanthines-Y.P. Chow and A.J. Repta 2:00 p.m.-36. Binding Studies of Phenylbutazone and Warfarin Sodium by a Fluorescent Probe Technique-H.W. Jun, L.A. Luzzi and P.L. Hsu 2:15 p.m.-37. Evaluation of Interactions Between Polymers and Low Molecular Weight Compounds by Gas Chromatography-J.L. Varsano and S.G. Gilbert 2:30 p.m.-38. Role of Drug Binding on Albumin Solution ViscosityJ.H. Wood, H.L. Smith and D.C. Jones 2:45 p.m.-39. A Thermodynamic Study of the Oil-Water Distribution of P-Alkylpyridines-K.C. Yeh and W.I. Higuchi 3:00 p.m.-40. Determination of Critical Micelle Concentrations and Partial Specific Volumes of Polysorbates 20, 60 and 80 from the Densities of Their Aqueous Solutions-B. Farhadieh 3:15 p.m.-41. A New Method for the Determination of the Critica I Micelle Concentration. The C.M.C. of Tetracaine HCI-J:H. Wood, B.M. Richard and H.L. Smith 3:30 p.m.-42. The Interaction of Radiolabeled Cetyltrimethylammonium Ion With Insoluble Monomolecular Films of Selected Fatty Acids and Phospholipids-J. Weiss and G. Zografi 3:45 p.m.-43. The Interaction of Cholesterol With Dibenzanthracenes at the Air-Water Interface-A.A. Belmonte and J. Swarbrick 4:00 p.m.-44. Separation and Nanogram Range Detection of the p-Nitrobenzyl Esters of PGF2a, PGE 2 and PGA 2 Using Liquid Chromatography-W. Morozowich 4:15 p.m.-45. MolecularOrbital Calculation of Various BarbituratesB.J. Laprade, K.S. Alexander, H. Petersen Jr. and A.N. Paruta

and Oral Administration-R.B. Smith, L.W. Dittert, W.O. Griffen Jr. and J.T. Doluisio 3:45 p.m.-63. In Vitro and In Vivo Availability of Two Commercial Digitoxin Tablets-R.G. Stoll, M.S. Christensen, E. Sakmar, D. Blair and J.G. Wagner 4:00 p.m.-64. Pharmacokinetic Profile of Sulfisoxazole Following IV, 1M and Oral Administration to Man-S.A. Kaplan, R.E. Weinfeld, C.W. Abruzzo and M. Lewis 4:15 p.m.-65. Pharmacokinetics of Spironolactone, Canrenone and Canrenoate-K in Humans-W. Sadee, M. Dagcioglu and R. Schroeder 4:30 p.m.-66. Interaction Kinetics Between Tolbutamide and Sulfaphenazole in Man-S.B. Matin, M. Rowland and J. Karam

kinetics in Man-W.J. Jusko and G.P. Lewis cycline-J. Adir and W.H. Barr

SIXTH SESSION-PHARMACOKINETICS IN ANIMALS

Wednesday, April 26, 8:15 a.m.-Room 100, Astrohall , Presiding-Stanley Kaplan and Bob Notari

8:15 a.m.-46. Effect of Sodium Taurodeoxycholate on Biologic Membranes: Release of Phosphorus, Phospholipid and Protein From the Everted Rat Smallintestine-S. Feldman, M. Reinhard and C. Willson 8:30 a.m.-47. Intestinal Drug Absorption and Metabolism IV. Kinetics of Intestinal Glucuronide and Sulfate Formation and Transfer-M. Shukur and W.H. Barr 8:45 a.m.-48. Intestinal Drug Absorption and Metabolism V. Inhibition of Intestinal Salicylamide Glucuronide and Sulfate Formation by Salicylic Acid-M. Chung and W.H. Barr 9:00 a.m.-49. Drug Transfer Across Rat Intestinal Mucosa-S.F. Forland, D.L. Wolfe, R.K. Nayak and L.Z. Benet 9:15 a.m.-50. Sodium Absorption From Phosphate Enemas in RatsH.W. Puffer and W.J. Crowell 9:30 a.m.-51. Plasma Salicylate Levels in Rats Following the Administration of Salicylate-Polyethylene Glycol SuppositoriesH.W. Puffer and W.J. Crowell 9:45 a.m.-52. Influence of Various Excipient Materials on the Absorption of Bishydroxycoumarin in Dogs-M.J. Akers, J.L. Lach and L.J. Fischer 10:00 a.m.-53. An In Situ Absorption Study of Aspirin and Salicylic Acid in the Rabbit Small Intestine-J.B. Hsieh, J.K. Lim and W.G. Crouthamel 10:15 a.m.-54. In Vivo Drug Absorption I. Preliminary Studies of the Rat Intestinal Absorption of n-Alkanoic Acids by the Static Method-N.F.H. Ho, J.T. Doluisio and W.I. Higuchi 10:30 a.m.-55. Drug-Cholestyramine Interactions III. Influence of Cholestyramine on the In Vivo Absorption of Flufenamic Acid in the Rat-H.A. Rosenberg and T.R. _Bates 10:45 a.m.-56. Drug-Cholestyramine I nteractions IV. Influence of Cholestyramine on the In Vivo Absorption of Bishydroxycoumarin in the Rat-A.V. TemboandT.R. Bates

After dark, Houston is a bejeweled lady of lights. The glittering skyscrapers towering over the 457-square mile metropolis are quiet after a busy day but the bounding energy of the nation's sixth largest city provides a variety of night-life. EIGHTH SESSION-DOSAGE FORM TECHNOLOGY

Thursday, April 27, 8:45 a.m.-Room 100, Astrohall Presiding-Joseph Samyn and Marvin Meyer

8:45 a.m.-67. Preparation of Stable Unbuffered 1 Percent Pilocarpine Hydrochloride Ophthalmic Solution-I.S. Gibbs and M.M. Tuckerman 9:00 a.m.-68. Solvolysis of Sodium Estrone Sulfate-A.R. Hurwitz 9:15 a.m.-69. A Rapid Nonisothermal-Isothermal Method for Stability Prediction-M.A. Zoglio, H.V. Maulding and W.C. Vincek 9:30 a.m.-70. Esters of Hydantoic Acids as Pro-Drugs of Hydantoins -V. Stella and T. Higuchi 9:45 a.m.-71. The Importance of Chain Length on the Physicochemical and Crystalline Properties of Organic HomologuesS.H. Yalkowsky, G.L. Flynn and T.G. Siunick 10:00 a.m.-72. Quantitative Analytical Method for the Determinations of Drugs Dispersed in Polymers Using Differential Scanning Calorimetry-F. Theeuwes, A. Hussain and T. Higuchi 10:15 a.m.-73. Shear Cell Measurements of Powders: The Use of a Simple Shear Cell To Determine Yield Loci-E.N. Hiestand, S.C. Valvani, E.P. Strzelinski, J.F. Glasscock Jr. and C.B. Peot 10:30 a.m.-74. Phase Transitions in Binary Mixtures of Cholesteryl Esters-S.G. Frank and B.G. Byrd Vol. NS12, No.3, March 1972

115

10:45 a.m.-75. An Investigation Into the Feasibility of Gas Permea· tion for the Protection of Oxygen Sensitive Systems-J.M. Lausier, R.J. Gerraughty and A.N. Paruta 11:00 a.m.-7G. The Kinetics of Coalescence of Dilute Oil·in·Water Emulsions-D.F. Bernstein, N.F.H. Ho and W.I. Higuchi 11:15 a.m.-77. Gas Absorption Properties of Pharmaceutical Suspension Systems-W. Stanaszek, B. Ecanow and R_ Levinson 11:30 a.m.-78. Filtration Rate Studies of Pharmaceutical Suspension Systems-A_ Dakkuri and B. Ecanow NINTH SESSION-MEMBRANE TRANSPORT

Thursday, April 27,1:30 p.m.-Room 100, Astrohall Presiding-Samuel Yalkowsky and Theodore Roseman 1:30 p.m.-79. The Permeation of Organic Compounds Through Polyethylene. Ii. The Influence of Structure and Experimental Variables-K. Nasim, M.C. Meyer and J. Autian 1:45 p.m.-80. Correlation and Prediction of Mass Transport Across Membranes I-Theoretical Treatment of Barrier Flux in Membrane and Diffusion layer Control-G.L. Flynn, S.H. Yalkowsky and 0.5. Carpenter 2:00 p.m.-81. Correlation and Prediction of Mass Transport Across Membranes Ii-Influence of Alkyl Chain Length on the Flux Determining Properties of Barrier and Diffusant-G.L. Flynn and S.H. Yalkowsky 2:15 p.m.-82. Two Step Interfacial Barrier Mechanism for the Transport of Micelle Solubilized Solute Across an Oil-Water InterfaceV. Surpuriya and W.I. Higuchi 2:30 p.m.-83. Model Transport Studies Utilizing Lecithin Spherules Ii. Transport of 3-0·Methy(.14C-D-Glucose-Z.T. Chowhan, T. Yotsuyanagi and W.I. Higuchi 2:45 p.m.-84. Theoretical Study of Drug Transport Processes in the Schulman-Type Cell Based on Two Film Theory-T. Yotsuyanagi and W.I. Higuchi

Economics and Administrative Science

2:30 p.m.-3. Public Utility Regulation of the Pharmaceutical In. dustry: An Initial Exploration-A.I. Wertheimer and E.K. Duch Jr. 2:45 p.m.-4. Change in the Competitive Structure ofthe Pharmaceu. tical Industry-J.P. Curran and J.D. McEvilia 3:00 p.m.-5. A Study of Occupational Satisfaction Differentials Among Three Classifications of Independent Retail Pharmacy Environments-W.H. Campbell and R.V. Evanson 3:15 p.m.-G. An Extramural Delphic Study of PharmacY-R.L. Mikeal and M.C. Smith 3:30 p.m.-7. An Investigation of Significance of the Number of Pharmacies and Physicians Utilized by Prescription Patients to Community Pharmacy Using Family Medication Record-M.S. Danian and C.M. Close 3:45 p.m.-8. Direct Economic Compensation For Community Pharmacists Offering Patient Prescription Record CardS-D.C. Huffman Jr. 4:00 p.m.-9. Prescription Record Systems-A Survey-V.J. Brown and E.B. Sommers 4:15 p.m.-10. A Survey of The Attitudes of Women in Monongalia County, West Virginia, Toward the Use of Contraceptives-B.G.S. Swisher and A.F. Wojcik FOURTH SESSION-BUSINESS

Monday, April 24, 4:30 p.m.-Room 202, Astrohall 1. 2. 3. 4. 5. G. 7. 8. 9. 10. 11. 12. 13. 14.

Call to order Chairman's report-Albert W. Jowdy Secretary's report-Michael D. Jacoff Membership committee-M. Keith Weikel Program committee-Maven J. Myers Committee on research awards-R.J. Hampton Committee on fall meetings-D.E. Leavitt Resolutions committee-Kenneth A. Shrader Unfinished business New business Nominating committee-Norman A. Campbell Installation of officers Chairman'S remarks-M. Keith Weikel Adjournment

Chairman-Albert W. Jowdy Chairman·elect-M. Keith Weikel Vice chairman-Maven J. Myers Secretary-MIchael D. Jacoff

FIRST SESSION

Monday, April 24, 9:00 a.m.-Room 202, Astrohall Symposium-Health Maintenance Organizations and Pharmaceutical Services in National Health Insurance Proposals for National Health Insurance-How Will Pharmacy Fit In?-R. Engel Health Maintenance Organizations-A Panacea for the Future?G.Riso Pharmaceutical Services in the Highly Organized HMO StructureR.Johnson Pharmaceutical Services in an HMO Structure Utilizing EXistingCommunity Facilities-R. Abrams Undergraduate Student Paper SECOND SESSION

Monday, April 24, 11:00 a.m.-Room 202, Astrohall 11:00 a.m.-~. A Study of the Relationships of Drug Dosage Forms, Therapeutic Class and Pharmaceutical Services With the Gross Margins on Prescription Drugs-J.P. Gagnon and C.A. Rodowskas 11:15 a.m.-2. Pharmaceutical Product Pricing and the Cost of Therapy-J.P. Cu rran and J.D. McEvilia 11:30 a.m.-3. Pharmacists' and Physicians' Attitudes Toward Removal of the Prohibition on Brand Substitution: A Comparative Study-W.C. McCormick and R.W. Hammel 11:45 a.m.-4. The Determination and Evaluation of the Consumer Price Differentials Between Generic and Brand Name Prescriptions-A. K. Gumbhir and C.A. Rodowskas

Industrial Pharmaceutical Technology Chairman-Arnold D. Marcus Chairman·elect-Ralph S. Levi Vice chairman-James C. Boylan Past chairman-W. Mayo Higgins Secretary·treasurer-Arge Drubulis

FIRST SESSION

Monday, April 24, 9:00 a.m.-Room 107, Astrohall Symposium-Product Optimization Moderator-R. Cohn 9:00 a.m.-Dosage Form Optimization Through the Use of a Com· puter-General Principles-S. Willsky 10:00 a.m.-Dosage Form Optimization Through the Use of a Com· puter-An Actual Experience-J. Schwartz, J. Flamholz and R. Press 11:00 a.m.-Optimization Under Production Conditions-W. Young SECOND SESSION

Monday, April 24, 2:00 p.m.-Room 107, Astrohall Symposium-New Considerations in Drug Administration Moderator-W. Tillman 2:00 p.m.-Individual Variation in Drug Response-B. La Du 3:00 p.m.-New Approaches in Drug Administration-J. Folkman THIRD SESSION

THIRD SESSION

Monday, April 24, 4:00 p.m.

Monday, April 24, 2:00 p.m.-Room 202, Astrohall

Idea Swapping Workshops

2:00 p.m.-I. Small Town Population as a Factor Influencing Prescription Trade Retention-R.A. Wills Jr. 2:15 p.m.-2. An EXperimental Analysis of Pharmacist-Patient Verbal Communication in Retail Pharmacy-J.A. Kotzan and G.H. Williams

116

Journal of the AMERICAN PHARMACEUTICAL ASSOCIATION

Shelf-Life Determination and Expiration Dating-Room 401, Astrohall Workshop Leader-T. Benny Microbiological Control of Nonsterile Products-Room 402, Astrohall Workshop Leader-H. Wolkoff

New Production Equipment, Processes and Automation-Room 403, Astrohall Workshop Leader-R. Castello Good Manufacturing Practices-Room 404, Astrohall Workshop Leader-P. Rasanen

FOURTH SESSION

Tuesday, April 25, 9:00 a.m.-Room 107, Astrohall Moderator-E. Russo

9:00 a.m.-Workshop Leader Reports 10:00 a.m.-The Use of Photography to Solve Development and Production Problems-W. Eastman

Academy section cliairmen-(left to right) William I. Higuchi, basic pharmaceutics; Albert W. Jowdy, economics and administrative science; Arnold D. Marcus, industrial pharmaceutical technology.

FIFTH SESSION-BUSINESS

Tuesday, April 25,11:15 a.m.-Room 107, Astrohall 1. Executive Committee Report-Arnold Marcus and Arge Drubulis 2. Summary of Committee Activities A. Program-R. Levi B. Membership-I. Butensky C. Regional meetings-R.E. Phares Jr. D. Audio-visual-G. Banker E. Education-A. Mlodozeniec F. Screening papers-K.C. Kwan and E.J. Schwartz G. Awards-W.M. Higgins H. Specifications-Tableting-F.W. Goodhart I. Specifications-Aerosol-J. Sciarra J. Fall program, 1971-J. Boylan K. Fall program, 1972-H. Wolkoff L. Procedural guides-C. Lintner M. Speakers exchange-G.J. Jackson 3. Unfinished business 4. New business 5. Report of nominating committee-W.M. Higgins 6. Installation of officers

Academy section chairmen-(left) Eugene C. Jorgensen, medicinal chemistry; (below, left to right) Erik H. Jensen, pharmaceutical analysis and control; David P. Carew, pharmacognosy and natural products; Tom S. Miya, pharmacology and toxicology.

SIXTH SESSION-LUNCHEON

Tuesday, April 25, 12:15 p.m.-Room 111, Astrohall Address-The Search for Extraterrestrial Life-Dr. G.P. Shulman, Casa Loma College, Pacoima, California-I nvestigator for NASA's Viking Mars Lander Project. (Tickets sold at APhA registration desk, Astrohall, and Academy Office, Room 101-103, Astrohall)

SEVENTH SESSION

Tuesday, April 25, 2:30 p.m.-Room 107, Astrohall Symposium-Current Status of Dissolution Testing Moderator-A. Marcus

2:30 p.m.-Report of PMA Committee on Dissolution Testing-

Academy section secretaries.-{left to rifi"ht) Arthur R. Mlodozeniec, basic pharmaceutics; Michael D. Jacoff, economics and administrative science; Arge Drubulis, industrial pharmaceutical technology.

N. Atwater

3:00 p.m.-Report of Academy of Pharmaceutical Sciences Committee on Dissolution-Methodology for Solid Dosage Forms-J. Poole

3:30 p.m.-Report of USP Advisory Panel on In Vitro Methods for Bioavailability Testing-L. Schroeter

4:00 p.m.-Panel discussion and discussion from the floor

EIGHTH SESSION

Wednesday, April 26, 9:00 a.m.-Room 107, Astrohall Presiding-G. Irwin and S. Motola

Academy section secretaries.-( left) Blaine M. Sutton, medicinal chemistry; (below, left to right) Lee T. G irady, pharmaceutical analysis and control; Jane F. pmele, pharmacology and toxicology; George H. Constantine Jr., pharmacognosy and natural products.

9:00 a.m.-I. Dustiness of Pharmaceutical Formulations.

I. Instrumentation-G. Gold, R.N. Duvall, B.T. Palermo and R.L. Hurtle 9:25 a.m.-2. Rapid Determination of Color Stability of Tablet Formulations-P. Turi, D. Brusco, H.V. Maulding, R.A. Tausenfreund and A.F. Michaelis 9:50 a.m.-3. Cross-Linked Polyvinylpyrrolidone Evaluated in Comparison With Other Tablet Disintegrating Agents-S.S. Kornblum and S.B. Stoopak 10:15 a.m.-4. Magnesium Lauryl Sulfate-Soluble LubricantH.C. Caldwell and W.J. Westlake 10:40 a.m.-5. Evaluation of Tablet-Breaking Strength TestersF.W. Goodhart, J.R. Draper and F.C. Ninger 11:05 a.m.-Open for student ,.)aper Vol. NS12, No.3, March 1972

117

NINTH SESSION

Thursday, April 27, 2:00 p.m.-Room 107, Astrohall Presiding-A. Goldberg and J. Schwartz 2:00 a.m.-6. Fluonic Control System for Ideal Blending in Pharmaceutical Manufacturing-H.S. Hayre and V. Das Gupta 2:25 a.m.-7. Preparation and Properties of New Stable Antacid Compositions Based on Aluminum Hydroxide and Hydroxy Magnesium Aminoacetate-S.M. Beekman 2:50a.m.-8. EffectofMoistureon Physical Characteristics of Tablets Prepared From Direct Compression Excipients-S.A. Sangekar, M. Sarli and P.R. Sheth 3:15 a.m.-9. Wall-Thickness of Microcapsules Made by Complex Coacervation-P.L. Madan, L.A. Luzzi and J.C. Price 3:40 a.m.-10. Effect of Variables on Gelatin-Acacia Coacervate Volume-A.B. Dhruv, T.E. Needham and L.A. Luzzi 4:05 a.m.-1l. Factors Influencing Microencapsulation of a Waxy Solid by Complex Coacervation-P.L. Madan, L.A. Luzzi and J.C. Price

Medicinal Chemistry Chairman-Eugene C. Jorgensen Chairman-elect-Lemont B. Kier Vice chairman-Robert A. Wiley Secretary-Blaine M. Sutton

FIRST SESSION

Tuesday, April 25, 9:00 a.m.-Room 307, Astrohall

10:45 a.m.-8. 3- and 4-Substituted Piperidazines as Potential Analgetics-M.J. Kornet and H.S.I. Tan 11:00 a.m.-9. 2-Ureido-4-Thiazolylmethoxyamines asAnti-lnflammatory Agents-B.L. Reavlin and G.H. Hamor 11:15 a.m.-10. Synthesis of Chlorhexidine Analogs as Potential I nhibitors of Dental Plaque-V.D. Warner and D.B. Mirth 11:30 a.m.-1l. The Hydrolysis Pattern of Steroidal Oximes and Their Derivatives-R.E. Huettemann and M.P. Shroff 11:45 a.m.-12. Undergraduate student paper FIFTH SESSION

Wednesday, April 26, 3:00 p.m.-Room 402, Astrohall Presiding-Ronald L. Jacoby 3:00 p.m.-13. The Application of NM R Spectroscopy to Conformational Analysis: A Study of Some Aromatic and 9-AcridaneN,N-Dimethylcarboxylic Acid Amides-M.B. Shambhu, G.A. Digenis and R.J. Moser 3:15 p.m.-14. Simplified NM R Spectra of Bifunctional Tropanes Induced by the Paramagnetic Shift Reagent Eu(DPM)a-D.M. Yourtee, B.F. Grabowski, G.S. Chapell and R.A. Sandmann 3:30 p.m.-15. Phototautomerism of the Warfarin Cation in the Lowest Excited Singlet State Via an Intramolecular Hydrogen BridgeG.J. Yakatan, R.J. Juneau and S.G. Schulman 3:45 p.m.-16. On the Electronic Structures of9-Aminoacridine, Quinacrine and Their Conjugate Acids-A.C. Capomacchia and S.G. Schulman 4:00 p.m.-17. Acidity Dependence of the Fluorescences of Pamaquine and 6-Methoxy-8-Aminoquinoline-K. Abate and S.G. Schulman 4:15 p.m.-18. Intramolecular Proton Transfer in the Lowest Excited Singlet State of Salicylic Acid and Some Related CompoundsC.l. Miller, P.J. Kovi and S.G. Schulman

Symposium-Opiate Addiction I Presiding-Wendel L. Nelson 9:00 a.m.-Welcome-Arthur S. Keats 9:10 a.m.-Detection and Identification of Opiates in Biological Materials-S.J. Mule 10:05 a.m.-Biochemistry and Pharmacology ofthe Addictive Process -A. Goldstein 11:00 a.m.-Structure-Activity Relationships and Design of Narcotic Antagonists-R.E. Willette SECOND SESSION

Tuesday, April 25, 1:30 p.m.-Room 307, Astrohall Symposium-Opiate Addiction" Presiding-Arthur S. Keats 1:30 p.m.-Methadone Maintenance Programs: Past, Present and Future-C.L. Bowden 2:25 p.m.-The Antagonist Approach to Addiction Treatment-W.R. Martin 3:20 p.m.-Approaches to the Treatment and Control of Opiate Addiction-R.E. Meyer 4:15 p.m.-Panel discussion THIRD SESSION-BUSINESS

Tuesday, April 25, 5:00 p.m.-Room 307, Astrohall FOURTH SESSION

Wednesday, April 26, 9:00 a.m.-Room 402, Astrohall

Astroworld, an unequaled cosmos of family entertainment, features 57 acres of rides and attractions. Fun and frolic await visitors as they cross the bridge adjacent to the stadium complex to this adventure land which features such innovative amusement park offerings as Americana Square, Western Junction, Oriental Corner and the European Village. Among the diverse rides at Astroworld are the Wagon Wheel, the Black D ragon, the Astrowheel, the Astroway and, projecting 340 feet into the air, the Astroneedle. Astroworld will be open Saturday and Sunday preceding and following the annual meeting; tickets will be on sale at the APhA Registration Desk.

Presiding-Jaime N. Delgado 9:00 a.m.-l. Studies of Enzyme Active Sites: Synthesis and Catalytic Activities of Peptide Esterase Models-A. Kapoor, K.P. Munnelly and A.N. Sarwal 9:15 a.m.-2. Bicyclic Thiadiazole I-M.M. Kochhar 9:30 a.m.-3. Potential Antiarrhythmic -Agents III: 4-Amino-N-[2(Su bstituted Am i no)Ethyl]-2,6-Dimethyl benzam ides-D. K. Yung, E.K.F.Lo and M.M. Vohra 9:45 a.m.-4. Structural Requirements for Centrally Acting Drugs 1E.J. lien and G.L. Tong 10:00 a.m.-5. Structural Requirements for Centrally Acting Drugs "-E.J.lien, J.T. Chou, L.l.lien and G.L. Tong 10:15 a.m.-6. Synthesis of Potential Adrenergic Blocking Agents: 2-Substituted ami n om eth yl nap hth o(2,3-b)-1, 4-dioxans-K.B. Parekh and W.H. Shelver 10:30 a.m.-7. The Synthesis of Conformationally Restricted Derivatives Containing a Beta Phenethyl Moiety-N.G.S. Rao and W.H. Shelver

118

Journal of the AMERICAN PHARMACEUTICAL ASSOCIATION

Pharmaceutical Analysis and Control Chairman-Erik H. Jensen Chairman-elect-Gerald S. Papariello Vice chairman-Carl R. Rehm Secretary-Lee T. Grady

EXECUTIVE COMMITTEE LUNCHEON

Monday, April 24, 12:00 noon-Parlor B, Astroworld FIRST SESSION-CONTRIBUTED PAPERS

Tuesday, April 25, 8:30 a.m.-Room 404, Astrohall Presiding-James T. Stewart and George Schwartzman

8:30 a.m.-Colorimetric Determination of Some Aromatic Drugs by Hydroxylation-K.S. Albert and K.A. Connors 8:45 a.m.-A Critical Evaluation of Fluorometric Assay for Quantita· tive Determination of Pancreatic Lipase in PharmaceuticalsD.H. House and S.S. Wagle 9:00 a.m.-Anodic Polarographic Analysis, Using a Glassy Carbon Electrode, of Acetaminophen in Dosage Forms-C.M. Shearer, K. Christenson, A. Mukherji and G.J. Papariello 9:15 a.m.-Automated Voltage·Scanning Polarographic AnalysisL.F. Cullen, M.P. Brindle and G.J. Papariello 9:30 a.m.-Determination of Ascorbic Acid in Pharmaceutical Dosage Forms Based on Oxidation at the Tubular Carbon Electrode-W.O. Mason, T.O. Gardner and J.T. Stewart 9:45 a.m.-Chlorpromazine Metabolism IV-A New Assay for Nano· determination of Chlorpromazine and its Sulfoxide-P.N. Kaul, M.W. Conway, R.E. Lehr and M.L. Clark 10:00 a.m.-Thin-Layer Chromatography Separation of Intact Glyceryl Trinitrate for Quantitative Determination in Sublingual TabletsD.B. Moore 10:15 a.m.-Determination of Ethylene Oxide Residues in MethylMethacrylate Polymer Powders by Gas Chromatography-L.A. Zagar 10:30 a.m.-Break 10:45 a.m.-Determination of Mercury in Pharmaceutica I Products by Neutron Activation Analysis-M. Margosis 11:00 a.m.-Selection of Best pH Range for the Extraction of AmineBromothymol Blue Complexes-H.B. Herman and V. Oas Gupta 11:15 a.m.-The Nonaqueous Determination of Esters by the Ferric Hydroxamate Procedure-J.A. Feldman 11:30 a.m.-Spectrophotometric Titration of Sulfonamides With Bromate-Bromide Solution-M.I. Blake, S.P. Agarwal and M.I. Walash 11:45 a.m.-Student Paper

4:00 p.m.-The Application of lon-Pair Methods to Drug Extraction From Biological Fluids I. Quantitative Determination of Biguanides in Urine-E.R. Garrett and J. Tsau 4:15 p.m.-Circular Dichroic Investigations of the Binding of Meta· Phenoxyphenyl Propionic Acid to Human Serum Albumin-J.H. Perrin 4:30 p.m.-Separation and Quantitation of Mixtures of the Most Commonly Abused Drugs-N.H. Chou lis ' 4:45 p.m.-Identification of the Most Commonly Abused Commercially Available Pharmaceutical Products-N.H. Chou lis 5:00 p.m.-Determination of Liothyronine and Thyroxine in Dried Thyroid by GLC-R. Bilous and J.J. Wind heuser FOURTH SESSION

Thursday, April 27, 9:00 a.m.-Room 111, Astrohall Symposium-Evaluation and Quality Control of New Packaging Materials for Drugs Presiding-Carl R. Rehm

Pharmacognosy and Natural Products Chairman-David P. Carew Chairman-elect-Jack L Beal Vice chairman-Philip Catalfomo Secretary-George H. Constantine Jr.

FI RST SESSION

Monday, April 24, 8:30 a.m.-Room 111, Astrohall SECOND SESSION-CONTRIBUTED PAPERS

Symposium-Peyote

Wednesday, April 26, 8:30 a.m.-Room 404, Astrohall

(Co-sponsored with the American Society of Pha rmacognosy)

Presiding-Joseph A. Mollica and L. F. Cullen

Presiding-Jerry L. McLaughlin

8:30 a.m.-A Semiautomated Calorimetric Determination of Vitamin

8:30 a.m.-I. Peyote-An I ntroduction-J.L. McLaughlin 8:50 a.m.-2. The Chemistry of Peyote Alkaloids-G.J. Kapadia 9:40 a.m.-3. Biosynthesis of Peyote Alkaloids-A.G. Paul 10:30 a.m.-4. Mescaline: The Chemistry and Pharmacology of its Analogs-A.T. Shulgin 11:20 a.m.-Question and discussion period

B, in Single Multivitamin Tablets-B.N. Kabadi 8:45 a.m.-GLC Analysis of Griseofulvin in Pharmaceutical Products -M. Margosis 9:00 a.m.-Dimethylformamide Dimethylacetal as a Methylating Agent for the Gas-Liquid Chromatography of Barbiturates and Related Compounds-V.S. Venturella, V.M. Gualario and R.E. Lang 9:15 a.m.-GLC Assay of Meprobamate and Related CarbamatesM.P. Rabinowitz, P. Reisberg and J.I. Bodin 9:30 a.m.-High-Pressure Liquid Chromatographic Analysis of the Benzodiazepine Ketazolam (U·28, 774)-O.J. Weber 9:45 a.m.-Adrenocortical Steroids in Pharmaceutical Preparations Analyzed by Liquid-Liquid Chromatography-M.C. Olson 10:00 a.m.-Steroid Determinations by HPLC in Complex Pharmaceutical Preparations-E.C. Jennings and W.C. Landgraf 10:15 a.m.-Determination of Sulfonamides and Local Anesthetics With 9-Chloroacridine by Quenching Fluorometry-J.T. Stewart and R.E. Wilkin 10:30 a.m.-Characterization of Crystalline Calcium D(+) Pantothenate by Physicochemical Assay Methods-S.H. Rubin, M.J. Frank, P.G. Trager and J.B.Johnson 10:45 a.m.-Aqueous Solubility and Dissolution of Triamcinolone Acetonide-R. Patel and L.H. Block 11:00 a.m.-A Versatile System for the Partition Chromatography of Corticosteroids and the Prediction of Their Elution Curves-D.J. Weber, T.R. Ennals and H. Mitchner 11:15 a.m.-Use of the Electron Probe in Pharmaceutical Quality Control-D.O. Maness, V.A. Yanchick, L.V. Allen Jr. and M. Wilkov 11:30 a.m.-Applications of Holography to Pharmaceutical Systems I. Tablet Experiments-E. Shefter, O. Mok, B. Resman and R.E. Kinzly

SECOND SESSION-INVITED PAPERS

Monday, April 24, 2:00 p.m.-Room 111, Astrohall Presiding-Kenneth L. Euler 2:00 p.m.-5. Antimicrobial Activity of Selected Mushroom Metabolites-R.G. Benedict and L.R. Brady 2:15 p.m.-6. Microbiologic Determination of Drug Partitioning, II: Functional Dependence of Partition Coefficient on Drug Concentration-S. Javldan and R.G. Mrtek . 2:30 p.m.-7. Microbiologic Determination of Drug Partitioning, III: Partition Coefficient Profiles of Several Antimicrobial AgentsS. Javidan and R.G. Mrtek 2:45 p.m.-8. Effects of Catnip (Nepeta cataria) on the Maze Performance of the Rat-A.G. Faulman, G.H. Constantine Jr. and G.B. Fink 3:00 p.m.-g. A Street-Drug Monitoring Program and Some ResultsJ. K. Brown, H.E. Appell, V.B. Chan, C.A. Gross and B.D. Winter.

~~

3:15 p.m.-lO. The Importance of the l41l-Hydroxyl Group in Digitoxigenin-W.A. Remers, B.K. Naidoo and H.B. Besch 3:30 p.m.-H. Preliminary Evidence for the Presence of Antigen E. in Dwarf Ragweed Plants-A. Shaflee, E.J. Staba and Y. Abul-Hajj 3:45 p.m.-12. A Highly Reliable Method for the Identification of Marijuana Using Combined Chromatography-Microscopy Techniques-A.B. Segelman

THIRD SESSION-CONTRIBUTED PAPERS THIRD SESSION-BUSINESS

Wednesday, April 26, 3:00 p.m.-Room 404, Astrohall Presiding-Lawrence J. Fischer and Lee T. Grady

3:00 p.m.-Gas Chromatographic Determination of Pentylenetetrazol in Biological Fluids-J.L. Story and J.T. Stewart

3:15 p.m.-GLC Determination of Methadone in Human Urine-J.L. Valentine, P.E. Wiegartand R.L. Charles 3:30 p.m.-Determination of Meprobamate in Water, Plasma and Urine by Gas Chromatography-L. Martis and R.H. Levy 3:45 p.m.-Gas Chromatographic Determination of Underivatized Sulthiame in Plasma-K.J. Simons and R.H. Levy

Monday, April 24, 4:00 p.m.-Room 111, Astrohall FOURTH SESSION-INVITED PAPERS

Wednesday, April 26, 9:00 a.m.-Room 401, Astrohall Presiding-Lee C. Schramm 9:00 a.m.-13. Cactus Alkaloids. XIV. Identification and Isolation of Peyote Alkaloids From the Mexican Cactus, Pe/ecyphora Asel/iformis-J.M. Neal, P.T. Sato, W.N. Howald and J.L. Mc· Laughlin

Vol. NS12, No.3, March 1972

119

9:15 a.m.-14. The Biosynthetic Production of Aberrant Alkaloids in Dolichothe/esphaerica-H. Rosenberg and A.G. Paul 9:30 a.m.-15. Tissue Culture of Camptotheca acuminata Decaisne (Nyssaceae)-R.C. Cooke, J.K. Brown and R.L. Smith 9:45 a.m.-16. Industrial Media and Diosgenin Strain Selection Studies of Dioscorea de/toidea Tissue Cultures-A. Mehta, S. Grewal and E.J. Staba 10:00 a.m.-17. Isolation of Skyrin From Hypomyces lactifluorum-D.E. Slagle and G.M. Hatfield 10:15 a.m.-18. A Method for the Extraction and Separation of Anthraquinone Glycosides-S. Chao Yung Su and N.M. Ferguson 10:30 a.m.-19. Separation of Anthraquinone Glycosides and Aglycones by Means of Electropaperography-T. Cheng and N.M. Ferguson 10:45 a.m.-20. Phenethylamine Derivatives From Coryphantha macromeris Var. Runyonni-W.J. Keller, J.L. McLaughlin and L.R. Brady 11:00 a.m.-21. Chemical Constituents of Cocculus carolinus D. C.D.J. Slatkin, J.E. Knapp, P.L. Schiff Jr. and N.J. Doorenbos 11:15 a.m.-22. Propyl Homologues of Cannabinoids From an Indian Variety of Cannabissativa L.-P. Fetterman and C.E. Turner 11:30 a.m.-23. Confirmed Structure of a Steroid Epoxide From Rhododendron macrophyllum-J.H. Block and G.H. Constantine Jr. 11:45 a.m.-24. Kilmer Prize Paper

The Port of Houston is credited with changing the density of the city from a moderately prospering timber and cotton center to one of the greatest international shipping hubs in the nation. From an observation deck at the Turning Basin, visitors may watch tugs maneuver big ocean-going vessels from many lands for the winding journey to the Gulf. Many of Houston's giant industrial complexes border the banks of the 40-foot deep canal.

11:15 a.m.-lO. Acute Toxicity and Preliminary Pharmacology of Some Azulylcarboxamides and Azulyl Amides-P.H. Doukas, R.S. Thompson and T.J. Speaker 11:30 a.m.-H. Antidotal Spectrum of Activated Charcoal-A.L. Picchioni, L. Chin, B.R. Duplisse and H.E. Laird 11:45 a.m.-12. The Effect of Selected Amino Acids on Ethanol Toxicity in Rats-C.O. Ward and R.J. Breglia 12:00 noon-13. Morphine-Induced Fetal Malformations. III. An Evaluation of Possible Mechanisms of Action-P.A. Arcuri and R.F. Gautieri SECOND SESSION-BUSINESS

Tuesday, April 25, 5:00 p.m.-Room 210, Astrohall THIRD SESSION

Wednesday, April 26, 9:00

a.~.-Room

403, Astrohall

Presiding-Harvey J. Kupferberg and C. JelleffCarr

9:00 a.m.-14. Induction of Cardenolide Metabolism by Spironolactone, Phenobarbital and Reserpine-S.J. Stohs, R.E. Talcott and M.M. EI-Olemy 9:15 a.m.-15. Mechanism Studies of Stress-Induced Barbital Tolerance in Rats-S.C. Rattan and M.M. Clay 9:30 a.m.-16. Distribution and Metabolism of Barbital in StressedBarbital Tolerant Rats-J.T. Huang and M.M. Clay 9:45 a.m.-17. Chlorpromazine Metabolism V-Distribution of the Metabolites in the Blood Components of Schizophrenic PatientsP.N: Kaul, M.K. Ticku and M.L. Clark 10:00 a.m.-18. A Radiotracer Distribution and Excretion Study of p,p'-DDT in Rats-R.H. i:Jishara, G.S. Born and J.E. Christian 10:15 a.m.-19. A Statistical Approach To Evaluate Different Treatment Effects Using Limited Number of Animals-R.H. Bishara, G.S. Born, J.E. Christian and V.L. Anderson 10:30 a.m.-20. Excretion and Tissue Distribution of Uniformly Labeled HC-Pentachlorophenol in Rats-R~V. Larsen, L. Kirsch, S.M. Shaw, J.E. Christian and G.S. Born 10:45 a.m.-21. Metabolism of Tritiated A9-Tetrahydrocannabinol. B.T. Ho, V. Estevez, L.F. Englert, G.E. Fritchie and W.M. Mcisaac 11:00 a.m.-22. Subcellular Binding of HC-Halothane in Mouse Liver and Brain-D.A. Blake and D.R. Brown 11:15 a.m.-23. A New Method for Analysis of Onset and Duration of Miotic Activity in the Rabbit Eye-M. Van Hoose, F.E. Leaders and W. Knowles 11:30 a.m.-24. Chlorpromazine Metabolism VI-Comparative Antiserotonergic and Adrenolytic Activities of Chlorpromazine and its Metabolites-P.R. Pabrai and P.N. Kaul 11:45 a.m.-25. A Comparison of the Onset of Ovabain-Induced Arrhythmias in Euthyroid and Hyperthyroid Animals-E.B. Thompson FOURTH SESSION We~nesday,

April 26, 2:00 p.m.-Room 403, Astrohall

Pharmacology and Toxicology

Presiding-Ralph E. Tedeschi and Sidney Riegelman

Chairman-Tom S. Miya Chairman-elect-lawrence C. Weaver Vice chairman-Ralph E. Tedeschi Secretary-Jane Frances Emele

2:00 p.m.-26. Metabolism of Isophosphamide by Rat Liver Microsomes-L.M. Allen and P.J. Creaven 2:15 p.m.-27. Effect of an Anticholinergic Agent on Riboflavin Absorption in Man-G. Levy, M. Gibaldi and J.A. Procknal 2:30 p.m.-28. Riboflavin Absorption in Children With Thyroid Disorders-G. Levy, M.H. MacGillivray and J.A. Procknal 2:45 p.m.-29. Salicylate Accumulation Kinetics in Man-G. Levy, J.R. Leonards and T. Tsuchiya 3:00 p.m.-30. Influence of Route of Administration on the Excretion of QX-572 in the Rat-J.E. Axelson, W. Conway and M. Gibaldi 3:15 p.m.-31. Correlation of Plasma 4,5-Bis(p-Methoxyphenyl)-2Phenylpyrrole-3-Acetonitrile Levels With Biologic Activity-D.G. Kaiser and E.M. Glenn 3:30 p.m.-32. The Pharmacokinetics and Toxicology of Metformin i'n Dogs-E.R. Garrett, P. Hinderling and J. Tsau 3:45 p.m.-33. Energy Transfer Reactions in Aqueous Solution. The Riboflavin Catalyzed Photodecomposition of 9-Aminomethylacridane-V.H. Mihranian and G.A. Digenis 4:00 p.m.-34. 'Deuterium Isotope Effect in the Enzymatic Transamination of L-Deuteriophenylanine to Deuteriophenylpyruvic Acid-H.J. Rhodes, R.B. Kluza and M.I. Blake 4:15 p.m •...:.35. Reinvestigation of the Effect of D 20 on the a-Chymotrypsin Catalyzed Hydrolysis of N-Acetyl-L-Tryptophan Ethyl Ester -K.G. Bhansali and A. Himoe 4:30 p.m.-36. The Metabolism of HC-Norepinephrine in the Central Nervous System-M.N. Grubb, V.E. Davis, H. Brown and M.M. Cray 4:45 p.m.-37. Selective Inhibition of Peripheral Monoamine Oxidase -B.T. Ho, P.M. Gardner and K.E. Walker 5:00 p.m.-38. Development and Evaluation of an Inhalation Aerosol of Glyceryl Trinitrate-A.M. Contractor, J.M. Snyder, H.P. Fletcher and R.F. Shangraw

FI RST SESSION

Monday, April 24, 9:00 a.m.-Room 403, Astrohall Presiding-Marvin H. Malone and Wallace L. Guess

9:00 a.m.-I. Selected Pharmacological Studies of Succinic Semialdehyde (SSA)-J.W. Kosh and G.D. Appelt 9:15 a.m.-2. Cardiovascular Effects of Reserpine, Yohimbine and Reserpine-Yohimbine Mixtures in the Intact Anesthetized DogM.N.Luckens 9:30 a.m.-3. Effects of Pentazocine and Narcotic Analgesics on Behavioral Arousal in the Rat-C.C. Brister and W.M. Davis 9:45 a.m.-4. An Investigation of the Hypotensor Response to 1Methyl-3-Phenethyl Thiourea in the Rat-E.L. Anderson and H.J. Jenkins 10:00 .a.m.-5. l?rugs ~rom Sea I-Pharmacological Screening of Manne Organisms Yielding Cardiovascular Activities-P.N. Kaul, P.R. Pabrai and M. Farmer 10:15 a.m.-6. ~rugs .F~om Sea II-Crassin Acetate, A Cytotoxic Agent of Marine Origin-A. Krishan, P.N. Kaul, D. Hsu and R. Frank 10:30 a.m.-7. A Method for Evaluating Moisturizing Creams and Lotions-B. Turek and N. Brudney 10:45 a.m.-8. Effect of Retinoyl Derivatives on Granuloma Formation Induced by Cottqn-Pellet-K.H. Lee, T.G. Tong and C.H. Woo 11:00 a.m.-9. Effects of Methacrylate Esters on Perfused Isolated Rabbit Heart-G.N. Mir, W.H. Lawrence and J. Autian

120

Journal of the AMERICAN PHARMACEUTICAL ASSOCIATION

FIFTH SESSION

Thursday, April 27, 9:00 a.m.-Room 202, Astrohall Symposium-Pharmacokinetics in Disease (Co·sponsored with Section on Medicinal Chemistry)

SIXTH SESSION

Thursday, April 27, 2:00 p.m.-Room 202, Astrohall (Co·sponsored with Section on Medicinal Chemistry)

Presiding-Ruth R. Levine and Gerhard Levy

Presiding-~uth

9:00 a.m.-I. The Absorption of Antibiotics in Disease Affecting the Gastrointestinal Tract-J.A. Davies 9:30 a.m.-2. Absorption in Parkinson's Disease-L. Calimlin 10:00 a.m.-Discussant-M. Weiner 10:30 a.m.-3. Hemodynamic Effects in Pharmacokinetics-M. Row· land 11:00 a.m.-4. Pharmacokinetic Approaches to ChemotherapyW.J.Jusko 11:30 a.m.-Discussant-J.J. Wagner

2:00 p.m.-I. The Effects of Altered Hepatic Flow on Drug Disposi. tion-A.S. Nies . . 2:30 p.m.-2. Effects of Uremia on Drug Metabolism-M. Black 3:00 p.m.-Recess . 3:30 p.m.-Discussant-S. Riegelman 4:00 p.m.-3. Drug Excretion in Diseased States-M.M. Reidenberg 4:30 p.m.-4. Drug Dosage in Patients With Kidney Disease: Theory and PraCtice-L. Dettli 5:00 p.m.-Discussant-M. Gibaldi

R. Levine and Gerhard Levy

Student APhA President-J. Craig Hostetler President·elect-Jack V. Nlcolais Vice president-Anthony L. Rogers Executive secretary-William F. McGhan Delegate-at·large-Lawrence E. Patterson Regional delegates-James E. Francis, Jon M. Furbee, Richard J. Hartig, Jerald R. Jackman, Janet E. Oates, Christine A. Sczupak, Conrad SImonds, David P. Vorozilchak EXECUTIVE COMMITTEE, REGIONAL DELEGATES, COMMITTEE AND SUBCOMMITTEE CHAIRMEN

Reference committee workshop A-organizational affairs-Room 403, Astroha II Presiding-Margaret M. Szymczak Reference committee workshop B-p rofessional affairs-Room 404, Astrohall Presiding-Sharon L. Roquemore Refe rence committee workshop C-public affairs- Room Astrohall . PreSiding-Warren J. Kingdon

401,

Thursday, April 20, 7:00 p.m.-Parlor B, Astroworld Presiding-J. Craig Hostetler

STUDENT APhA REFERENCE COMMITTEES

Friday, April 21, 8:00 p.m. FIRST SESSION

Friday, April 21, 8:45 a.m.-Rooms 300·307, Astrohall

Reference committee A-organizational affairs-Room 403, Astrohall Presiding-Christine A. Sczupak .

Presiding-J. Craig Hostetler

Reference committee B-professional affairs-Room 404, Astrohall Presid fng-David P. Vorozilchak

1. Invocation 2. Welcome on behalf of APhA-Lloyd M. Parks, president 3. Welcome on behalf of ~ost chapters

Reference committee C-public affairs-Room 401, Astrohall Presiding-James E. Francis

4. Roll call and seating of delegates 5. Report on National Interdisciplinary Health Manpower Conference-J. Craig Hostetler . 6. Report on Project SPEED-William F. McGhan 7. Report of executive committee-J. Craig Hostetler

RESOLUTIONS COMMITTEE OPEN SJ;:SSION

Saturday, April 22, 9:00 a.m.-Room 202, Astrohall Presiding-James R. Boyd

STUDENT APhA RAP SESSIONS

Friday, April 21, 1:.30 p.m.·

PAPERS REVIEW FORUM

Pharmaceutical Education-Room 403, Astrohall Presiding-Nancy I. Waterman

Saturday, April 22, 1:00 p.m.-Room 202, Astrohall Presiding-Jeff T. Byrd

Health Manpower-Room 404, Astrohall Presiding-J. Craig Hostetler Community Health-Room 202, Astrohall Presiding-Joseph V. Jones

NOMINATING COMMITTEE

Saturday, April 22, 1:00 p.m.-Room 213, Astrohall

Minority Affairs-Room 210, Astrohall Presiding-John J. Scrivens

Presiding-Warren J. Kingdon

Comprehensive Health Care-Room 213, Astrohall Presiding-Janet E. Oates

NATIONAL ADVISORY COMMITTEE

Chapter Services-Room 401, Astrohall Presiding-David P. Petrino

Saturday, April 22, 3:00 p.m.-Room 210, Astrohall Presiding-C. Larry Thomasson

(' Rap sessions will be repeated at 3:30 p.m. allowing participants to attend other rap sessions of their choice) CANDIDATE REVIEW STUDENT APhA REFERENCE COMMITTEE WORKSHOPS

Saturday, April 22, 3:00 p.m.-Room 202, Astrohall

Friday, April 21, 6:30 p.m.

Presiding-Anthony L. Rogers Vol. NS12, No. 3, March 1972

121